Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_IL2_STAT5_SIGNALING
Enrichment Score (ES)0.4074982
Normalized Enrichment Score (NES)1.6344595
Nominal p-value0.00152207
FDR q-value0.006282693
FWER p-Value0.056
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_IL2_STAT5_SIGNALING   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CXCL10NACXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 10164.6310.0346Yes
2TNFRSF8NATNFRSF8
Entrez,  Source
tumor necrosis factor receptor superfamily, member 8434.1900.0652Yes
3IL1RL1NAIL1RL1
Entrez,  Source
interleukin 1 receptor-like 1543.9720.0950Yes
4TRAF1NATRAF1
Entrez,  Source
TNF receptor-associated factor 1893.3230.1186Yes
5NFKBIZNANFKBIZ
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta943.2780.1434Yes
6NT5ENANT5E
Entrez,  Source
5'-nucleotidase, ecto (CD73)963.2420.1682Yes
7MXD1NAMXD1
Entrez,  Source
MAX dimerization protein 11153.0590.1906Yes
8SPRY4NASPRY4
Entrez,  Source
sprouty homolog 4 (Drosophila)2082.3710.2036Yes
9TGM2NATGM2
Entrez,  Source
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)2132.3440.2213Yes
10PHLDA1NAPHLDA1
Entrez,  Source
pleckstrin homology-like domain, family A, member 12212.3180.2387Yes
11TNFRSF21NATNFRSF21
Entrez,  Source
tumor necrosis factor receptor superfamily, member 212332.2500.2553Yes
12PRKCHNAPRKCH
Entrez,  Source
protein kinase C, eta3461.8350.2631Yes
13PLECNA4381.6270.2705Yes
14LRIG1NALRIG1
Entrez,  Source
leucine-rich repeats and immunoglobulin-like domains 14581.5960.2817Yes
15IL1R2NAIL1R2
Entrez,  Source
interleukin 1 receptor, type II4921.5510.2917Yes
16BCL2L1NABCL2L1
Entrez,  Source
BCL2-like 15121.5260.3023Yes
17CD44NACD44
Entrez,  Source
CD44 molecule (Indian blood group)5151.5230.3139Yes
18IL4RNAIL4R
Entrez,  Source
interleukin 4 receptor5471.4860.3235Yes
19HOPXNA6151.4040.3305Yes
20TTC39BNA7641.2730.3320Yes
21SERPINC1NASERPINC1
Entrez,  Source
serpin peptidase inhibitor, clade C (antithrombin), member 18461.2110.3368Yes
22COL6A1NACOL6A1
Entrez,  Source
collagen, type VI, alpha 110541.0910.3336Yes
23PLSCR1NAPLSCR1
Entrez,  Source
phospholipid scramblase 110711.0830.3410Yes
24ETV4NAETV4
Entrez,  Source
ets variant gene 4 (E1A enhancer binding protein, E1AF)11081.0660.3472Yes
25ALCAMNAALCAM
Entrez,  Source
activated leukocyte cell adhesion molecule11561.0420.3525Yes
26MAFFNAMAFF
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)12371.0040.3558Yes
27CCND3NACCND3
Entrez,  Source
cyclin D313470.9640.3571Yes
28IFITM3NAIFITM3
Entrez,  Source
interferon induced transmembrane protein 3 (1-8U)13610.9590.3637Yes
29SLC1A5NASLC1A5
Entrez,  Source
solute carrier family 1 (neutral amino acid transporter), member 515370.9000.3608Yes
30AHNAKNAAHNAK
Entrez,  Source
AHNAK nucleoprotein (desmoyokin)15540.8950.3668Yes
31CSF1NACSF1
Entrez,  Source
colony stimulating factor 1 (macrophage)16080.8800.3706Yes
32RNH1NARNH1
Entrez,  Source
ribonuclease/angiogenin inhibitor 116980.8500.3721Yes
33P2RX4NAP2RX4
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 417700.8350.3746Yes
34NRP1NANRP1
Entrez,  Source
neuropilin 117870.8320.3801Yes
35GPR83NAGPR83
Entrez,  Source
G protein-coupled receptor 8320720.7710.3702Yes
36NOP2NA20780.7710.3758Yes
37LIFNALIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)21410.7550.3781Yes
38IL18R1NAIL18R1
Entrez,  Source
interleukin 18 receptor 121610.7520.3828Yes
39SYNGR2NASYNGR2
Entrez,  Source
synaptogyrin 223120.7210.3800Yes
40PDCD2LNAPDCD2L
Entrez,  Source
programmed cell death 2-like23710.7080.3822Yes
41TNFSF10NATNFSF10
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 1024360.6960.3839Yes
42SOCS1NASOCS1
Entrez,  Source
suppressor of cytokine signaling 124850.6860.3865Yes
43IL2RANAIL2RA
Entrez,  Source
interleukin 2 receptor, alpha26050.6650.3850Yes
44CKAP4NACKAP4
Entrez,  Source
cytoskeleton-associated protein 426230.6620.3891Yes
45AHRNAAHR
Entrez,  Source
aryl hydrocarbon receptor26860.6500.3906Yes
46XBP1NAXBP1
Entrez,  Source
X-box binding protein 128460.6240.3866Yes
47CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase29030.6130.3881Yes
48BHLHE40NA29730.6010.3889Yes
49PNPNA30250.5920.3906Yes
50ITGA6NAITGA6
Entrez,  Source
integrin, alpha 630330.5910.3947Yes
51PLAGL1NAPLAGL1
Entrez,  Source
pleiomorphic adenoma gene-like 130730.5850.3970Yes
52ITIH5NAITIH5
Entrez,  Source
inter-alpha (globulin) inhibitor H530970.5820.4002Yes
53IFNGR1NAIFNGR1
Entrez,  Source
interferon gamma receptor 131510.5750.4017Yes
54ECM1NAECM1
Entrez,  Source
extracellular matrix protein 132510.5590.4004Yes
55PUS1NAPUS1
Entrez,  Source
pseudouridylate synthase 132770.5560.4033Yes
56CDC6NACDC6
Entrez,  Source
CDC6 cell division cycle 6 homolog (S. cerevisiae)32790.5560.4075Yes
57CAPGNACAPG
Entrez,  Source
capping protein (actin filament), gelsolin-like34090.5350.4044No
58P4HA1NAP4HA1
Entrez,  Source
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I35070.5220.4030No
59TWSG1NATWSG1
Entrez,  Source
twisted gastrulation homolog 1 (Drosophila)35650.5150.4038No
60CISHNACISH
Entrez,  Source
cytokine inducible SH2-containing protein36020.5100.4057No
61CAPN3NACAPN3
Entrez,  Source
calpain 3, (p94)38480.4810.3957No
62PRAF2NAPRAF2
Entrez,  Source
PRA1 domain family, member 239160.4720.3956No
63DENND5ANA39240.4710.3988No
64TNFRSF1BNATNFRSF1B
Entrez,  Source
tumor necrosis factor receptor superfamily, member 1B41640.4390.3889No
65GLIPR2NA41800.4370.3914No
66PTGER2NAPTGER2
Entrez,  Source
prostaglandin E receptor 2 (subtype EP2), 53kDa43000.4220.3880No
67AMACRNAAMACR
Entrez,  Source
alpha-methylacyl-CoA racemase44800.4020.3811No
68MUC1NAMUC1
Entrez,  Source
mucin 1, cell surface associated46880.3840.3725No
69PTCH1NAPTCH1
Entrez,  Source
patched homolog 1 (Drosophila)47250.3800.3735No
70MAP3K8NAMAP3K8
Entrez,  Source
mitogen-activated protein kinase kinase kinase 847640.3760.3742No
71AHCYNAAHCY
Entrez,  Source
S-adenosylhomocysteine hydrolase48790.3640.3707No
72ICOSNAICOS
Entrez,  Source
inducible T-cell co-stimulator50090.3500.3662No
73GUCY1B3NAGUCY1B3
Entrez,  Source
guanylate cyclase 1, soluble, beta 351880.3330.3588No
74MAPKAPK2NAMAPKAPK2
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 252530.3270.3577No
75SOCS2NASOCS2
Entrez,  Source
suppressor of cytokine signaling 253640.3160.3540No
76ODC1NAODC1
Entrez,  Source
ornithine decarboxylase 154990.3030.3489No
77HUWE1NAHUWE1
Entrez,  Source
HECT, UBA and WWE domain containing 156350.2930.3436No
78RGS16NARGS16
Entrez,  Source
regulator of G-protein signalling 1656380.2930.3458No
79HK2NAHK2
Entrez,  Source
hexokinase 257600.2820.3412No
80BATFNABATF
Entrez,  Source
basic leucine zipper transcription factor, ATF-like57840.2790.3420No
81PENKNAPENK
Entrez,  Source
proenkephalin57930.2780.3437No
82CD81NACD81
Entrez,  Source
CD81 molecule58790.2710.3411No
83SLC39A8NASLC39A8
Entrez,  Source
solute carrier family 39 (zinc transporter), member 858870.2700.3428No
84COCHNACOCH
Entrez,  Source
coagulation factor C homolog, cochlin (Limulus polyphemus)59420.2670.3418No
85ARL4ANAARL4A
Entrez,  Source
ADP-ribosylation factor-like 4A62800.2380.3249No
86TNFRSF9NATNFRSF9
Entrez,  Source
tumor necrosis factor receptor superfamily, member 963500.2320.3228No
87FLT3LGNAFLT3LG
Entrez,  Source
fms-related tyrosine kinase 3 ligand64530.2250.3189No
88CCNE1NACCNE1
Entrez,  Source
cyclin E167720.1980.3027No
89IL10RANAIL10RA
Entrez,  Source
interleukin 10 receptor, alpha68370.1930.3006No
90GABARAPL1NAGABARAPL1
Entrez,  Source
GABA(A) receptor-associated protein like 168680.1900.3004No
91CCR4NACCR4
Entrez,  Source
chemokine (C-C motif) receptor 474340.1490.2701No
92SLC29A2NASLC29A2
Entrez,  Source
solute carrier family 29 (nucleoside transporters), member 274420.1480.2708No
93SELLNASELL
Entrez,  Source
selectin L (lymphocyte adhesion molecule 1)74810.1450.2698No
94POU2F1NAPOU2F1
Entrez,  Source
POU domain, class 2, transcription factor 177540.1260.2556No
95IL13NAIL13
Entrez,  Source
interleukin 1377700.1250.2558No
96WLSNA77940.1230.2554No
97SELPNASELP
Entrez,  Source
selectin P (granule membrane protein 140kDa, antigen CD62)78230.1210.2548No
98TIAM1NATIAM1
Entrez,  Source
T-cell lymphoma invasion and metastasis 179820.1090.2468No
99SNX9NASNX9
Entrez,  Source
sorting nexin 980100.1060.2461No
100LCLAT1NA80640.1020.2440No
101LTBNALTB
Entrez,  Source
lymphotoxin beta (TNF superfamily, member 3)81970.0930.2373No
102DCPSNADCPS
Entrez,  Source
decapping enzyme, scavenger83560.0820.2292No
103PTRH2NAPTRH2
Entrez,  Source
peptidyl-tRNA hydrolase 286880.0580.2112No
104KLF6NAKLF6
Entrez,  Source
Kruppel-like factor 687570.0540.2078No
105ITGAENAITGAE
Entrez,  Source
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)90400.0320.1924No
106BATF3NA92090.0200.1832No
107GSTO1NAGSTO1
Entrez,  Source
glutathione S-transferase omega 192240.0190.1826No
108UCK2NAUCK2
Entrez,  Source
uridine-cytidine kinase 292280.0190.1826No
109EMP1NAEMP1
Entrez,  Source
epithelial membrane protein 192560.0160.1812No
110ENPP1NAENPP1
Entrez,  Source
ectonucleotide pyrophosphatase/phosphodiesterase 194060.0070.1729No
111CA2NACA2
Entrez,  Source
carbonic anhydrase II95100.0000.1672No
112CSF2NACSF2
Entrez,  Source
colony stimulating factor 2 (granulocyte-macrophage)95750.0000.1636No
113GPR65NAGPR65
Entrez,  Source
G protein-coupled receptor 659725-0.0000.1553No
114UMPSNAUMPS
Entrez,  Source
uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)9751-0.0020.1540No
115F2RL2NAF2RL2
Entrez,  Source
coagulation factor II (thrombin) receptor-like 29769-0.0030.1531No
116PRNPNAPRNP
Entrez,  Source
prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)9809-0.0070.1509No
117HIPK2NAHIPK2
Entrez,  Source
homeodomain interacting protein kinase 29834-0.0090.1497No
118CST7NACST7
Entrez,  Source
cystatin F (leukocystatin)9891-0.0110.1466No
119AKAP2NAAKAP2
Entrez,  Source
A kinase (PRKA) anchor protein 29916-0.0140.1454No
120CD48NACD48
Entrez,  Source
CD48 molecule10024-0.0200.1396No
121CCND2NACCND2
Entrez,  Source
cyclin D210056-0.0230.1381No
122FAM126BNAFAM126B
Entrez,  Source
family with sequence similarity 126, member B10115-0.0270.1350No
123IGF1RNAIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor10119-0.0270.1351No
124GALMNAGALM
Entrez,  Source
galactose mutarotase (aldose 1-epimerase)10428-0.0440.1183No
125SWAP70NASWAP70
Entrez,  Source
-10625-0.0560.1078No
126SNX14NASNX14
Entrez,  Source
sorting nexin 1410691-0.0600.1046No
127MYO1ENAMYO1E
Entrez,  Source
myosin IE10821-0.0660.0980No
128EOMESNAEOMES
Entrez,  Source
eomesodermin homolog (Xenopus laevis)10858-0.0690.0965No
129TNFSF11NATNFSF11
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 1110953-0.0750.0918No
130CTLA4NACTLA4
Entrez,  Source
cytotoxic T-lymphocyte-associated protein 411316-0.0990.0725No
131MYO1CNAMYO1C
Entrez,  Source
myosin IC11592-0.1220.0581No
132TNFRSF18NATNFRSF18
Entrez,  Source
tumor necrosis factor receptor superfamily, member 1811806-0.1410.0473No
133IRF6NAIRF6
Entrez,  Source
interferon regulatory factor 611823-0.1420.0475No
134TLR7NATLR7
Entrez,  Source
toll-like receptor 711948-0.1510.0418No
135GADD45BNAGADD45B
Entrez,  Source
growth arrest and DNA-damage-inducible, beta11970-0.1530.0418No
136FAHNAFAH
Entrez,  Source
fumarylacetoacetate hydrolase (fumarylacetoacetase)12156-0.1690.0328No
137RORANARORA
Entrez,  Source
RAR-related orphan receptor A12379-0.1890.0219No
138CDCP1NACDCP1
Entrez,  Source
CUB domain containing protein 112432-0.1950.0205No
139IL2RBNAIL2RB
Entrez,  Source
interleukin 2 receptor, beta12478-0.1990.0195No
140RHOBNARHOB
Entrez,  Source
ras homolog gene family, member B12525-0.2040.0185No
141SYT11NASYT11
Entrez,  Source
synaptotagmin XI12606-0.2100.0156No
142TNFRSF4NATNFRSF4
Entrez,  Source
tumor necrosis factor receptor superfamily, member 412651-0.2150.0148No
143IKZF4NAIKZF4
Entrez,  Source
IKAROS family zinc finger 4 (Eos)12993-0.244-0.0023No
144RHOHNARHOH
Entrez,  Source
ras homolog gene family, member H13145-0.257-0.0087No
145RABGAP1LNARABGAP1L
Entrez,  Source
RAB GTPase activating protein 1-like13191-0.262-0.0092No
146NCOA3NANCOA3
Entrez,  Source
nuclear receptor coactivator 313227-0.265-0.0091No
147BMPR2NABMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)13239-0.266-0.0077No
148CD86NACD86
Entrez,  Source
CD86 molecule13386-0.280-0.0137No
149IGF2RNAIGF2R
Entrez,  Source
insulin-like growth factor 2 receptor13479-0.290-0.0166No
150PTH1RNA13705-0.311-0.0267No
151MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)13741-0.315-0.0263No
152IL3RANAIL3RA
Entrez,  Source
interleukin 3 receptor, alpha (low affinity)13810-0.322-0.0276No
153SPRED2NASPRED2
Entrez,  Source
sprouty-related, EVH1 domain containing 213836-0.324-0.0265No
154FURINNAFURIN
Entrez,  Source
furin (paired basic amino acid cleaving enzyme)13866-0.327-0.0256No
155ABCB1NAABCB1
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 113944-0.338-0.0273No
156CYFIP1NACYFIP1
Entrez,  Source
cytoplasmic FMR1 interacting protein 113964-0.340-0.0257No
157SCN9ANASCN9A
Entrez,  Source
sodium channel, voltage-gated, type IX, alpha13982-0.342-0.0241No
158AGERNAAGER
Entrez,  Source
advanced glycosylation end product-specific receptor14298-0.379-0.0387No
159IRF8NAIRF8
Entrez,  Source
interferon regulatory factor 814315-0.381-0.0367No
160ITGAVNAITGAV
Entrez,  Source
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)14332-0.383-0.0346No
161IKZF2NAIKZF2
Entrez,  Source
IKAROS family zinc finger 2 (Helios)14335-0.383-0.0318No
162BCL2NABCL2
Entrez,  Source
B-cell CLL/lymphoma 214397-0.390-0.0322No
163PHTF2NAPHTF2
Entrez,  Source
putative homeodomain transcription factor 214513-0.407-0.0355No
164ANXA4NAANXA4
Entrez,  Source
annexin A414557-0.414-0.0347No
165GATA1NAGATA1
Entrez,  Source
GATA binding protein 1 (globin transcription factor 1)14628-0.421-0.0354No
166FGL2NAFGL2
Entrez,  Source
fibrinogen-like 214664-0.426-0.0341No
167SERPINB6NASERPINB6
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 614719-0.432-0.0338No
168CDC42SE2NACDC42SE2
Entrez,  Source
CDC42 small effector 214736-0.435-0.0313No
169ST3GAL4NAST3GAL4
Entrez,  Source
ST3 beta-galactoside alpha-2,3-sialyltransferase 414866-0.458-0.0350No
170S100A1NAS100A1
Entrez,  Source
S100 calcium binding protein A114873-0.458-0.0318No
171SPP1NASPP1
Entrez,  Source
secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)15059-0.484-0.0384No
172ADAM19NAADAM19
Entrez,  Source
ADAM metallopeptidase domain 19 (meltrin beta)15118-0.491-0.0379No
173RRAGDNARRAGD
Entrez,  Source
Ras-related GTP binding D15141-0.494-0.0353No
174SLC2A3NASLC2A3
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 315473-0.547-0.0496No
175IL10NAIL10
Entrez,  Source
interleukin 1015556-0.562-0.0498No
176CD79BNACD79B
Entrez,  Source
CD79b molecule, immunoglobulin-associated beta15586-0.568-0.0471No
177PLIN2NA15679-0.586-0.0477No
178IRF4NAIRF4
Entrez,  Source
interferon regulatory factor 415869-0.627-0.0535No
179NCS1NA15873-0.627-0.0488No
180LRRC8CNALRRC8C
Entrez,  Source
leucine rich repeat containing 8 family, member C15948-0.642-0.0480No
181GBP4NAGBP4
Entrez,  Source
guanylate binding protein 416012-0.658-0.0465No
182SHENASHE
Entrez,  Source
Src homology 2 domain containing E16031-0.663-0.0424No
183GPX4NAGPX4
Entrez,  Source
glutathione peroxidase 4 (phospholipid hydroperoxidase)16319-0.740-0.0527No
184SH3BGRL2NASH3BGRL2
Entrez,  Source
SH3 domain binding glutamic acid-rich protein like 216390-0.761-0.0508No
185BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 216401-0.765-0.0455No
186NFIL3NANFIL3
Entrez,  Source
nuclear factor, interleukin 3 regulated16520-0.802-0.0459No
187MAP6NAMAP6
Entrez,  Source
microtubule-associated protein 616593-0.824-0.0436No
188PIM1NAPIM1
Entrez,  Source
pim-1 oncogene17087-1.007-0.0634No
189SMPDL3ANASMPDL3A
Entrez,  Source
sphingomyelin phosphodiesterase, acid-like 3A17529-1.277-0.0781No
190CDKN1CNACDKN1C
Entrez,  Source
cyclin-dependent kinase inhibitor 1C (p57, Kip2)17588-1.334-0.0711No
191NDRG1NANDRG1
Entrez,  Source
N-myc downstream regulated gene 117599-1.346-0.0614No
192CTSZNACTSZ
Entrez,  Source
cathepsin Z17795-1.610-0.0599No
193DHRS3NADHRS3
Entrez,  Source
dehydrogenase/reductase (SDR family) member 317931-1.939-0.0526No
194CD83NACD83
Entrez,  Source
CD83 molecule18007-2.314-0.0391No
195ENO3NAENO3
Entrez,  Source
enolase 3 (beta, muscle)18098-2.969-0.0213No
196APLP1NAAPLP1
Entrez,  Source
amyloid beta (A4) precursor-like protein 118119-3.2820.0027No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_IL2_STAT5_SIGNALING   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_IL2_STAT5_SIGNALING: Random ES distribution   
Gene set null distribution of ES for HALLMARK_IL2_STAT5_SIGNALING