Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_HYPOXIA
Enrichment Score (ES)-0.31072104
Normalized Enrichment Score (NES)-1.3285652
Nominal p-value0.013513514
FDR q-value0.103858955
FWER p-Value0.533
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_HYPOXIA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)174.5960.0299No
2ISG20NAISG20
Entrez,  Source
interferon stimulated exonuclease gene 20kDa194.5610.0605No
3SDC4NASDC4
Entrez,  Source
syndecan 4 (amphiglycan, ryudocan)1053.1890.0772No
4PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor1402.7840.0940No
5CYR61NACYR61
Entrez,  Source
cysteine-rich, angiogenic inducer, 611712.5510.1095No
6PKP1NAPKP1
Entrez,  Source
plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)1992.4080.1242No
7TGM2NATGM2
Entrez,  Source
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)2132.3440.1392No
8ZFP36NAZFP36
Entrez,  Source
zinc finger protein 36, C3H type, homolog (mouse)2372.2360.1529No
9TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 32712.0950.1652No
10MT2ANAMT2A
Entrez,  Source
metallothionein 2A2742.0860.1791No
11SERPINE1NASERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 12902.0390.1919No
12F3NAF3
Entrez,  Source
coagulation factor III (thromboplastin, tissue factor)3011.9810.2047No
13TPBGNATPBG
Entrez,  Source
trophoblast glycoprotein4351.6430.2083No
14PLAC8NAPLAC8
Entrez,  Source
placenta-specific 86931.3290.2030No
15JUNNAJUN
Entrez,  Source
jun oncogene7181.3120.2104No
16HSPA5NAHSPA5
Entrez,  Source
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)7771.2630.2157No
17PPP1R15ANAPPP1R15A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15A8741.1910.2184No
18CTGFNACTGF
Entrez,  Source
connective tissue growth factor9671.1350.2209No
19IDSNAIDS
Entrez,  Source
iduronate 2-sulfatase (Hunter syndrome)9911.1260.2272No
20EXT1NAEXT1
Entrez,  Source
exostoses (multiple) 110171.1100.2332No
21EGFRNAEGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)10421.0980.2393No
22MAFFNAMAFF
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)12371.0040.2352No
23BCANNABCAN
Entrez,  Source
brevican13290.9710.2367No
24MAP3K1NAMAP3K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase 114060.9450.2388No
25GPC3NAGPC3
Entrez,  Source
glypican 315040.9100.2395No
26ADMNAADM
Entrez,  Source
adrenomedullin17220.8450.2331No
27MT1ENAMT1E
Entrez,  Source
metallothionein 1E (functional)18440.8190.2319No
28NCANNA19060.8070.2339No
29NAGKNANAGK
Entrez,  Source
N-acetylglucosamine kinase19130.8050.2390No
30COL5A1NACOL5A1
Entrez,  Source
collagen, type V, alpha 121450.7550.2312No
31GPC1NAGPC1
Entrez,  Source
glypican 122130.7420.2325No
32NR3C1NANR3C1
Entrez,  Source
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)22350.7360.2362No
33ANXA2NAANXA2
Entrez,  Source
annexin A222360.7360.2412No
34DDIT3NADDIT3
Entrez,  Source
DNA-damage-inducible transcript 322750.7290.2440No
35FOSL2NAFOSL2
Entrez,  Source
FOS-like antigen 222810.7280.2486No
36MYH9NAMYH9
Entrez,  Source
myosin, heavy chain 9, non-muscle24670.6910.2429No
37SDC2NASDC2
Entrez,  Source
syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan)28850.6170.2239No
38BHLHE40NA29730.6010.2231No
39ANGPTL4NAANGPTL4
Entrez,  Source
angiopoietin-like 431270.5780.2185No
40ETS1NAETS1
Entrez,  Source
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)33600.5420.2092No
41P4HA1NAP4HA1
Entrez,  Source
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I35070.5220.2046No
42ALDOANAALDOA
Entrez,  Source
aldolase A, fructose-bisphosphate36790.4990.1984No
43NDST2NANDST2
Entrez,  Source
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 237270.4940.1991No
44CITED2NACITED2
Entrez,  Source
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 238580.4800.1951No
45CSRP2NACSRP2
Entrez,  Source
cysteine and glycine-rich protein 240540.4540.1873No
46GCNT2NAGCNT2
Entrez,  Source
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)40590.4540.1901No
47P4HA2NAP4HA2
Entrez,  Source
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II42170.4330.1843No
48ADORA2BNAADORA2B
Entrez,  Source
adenosine A2b receptor47070.3820.1597No
49PFKPNAPFKP
Entrez,  Source
phosphofructokinase, platelet50620.3450.1423No
50HMOX1NAHMOX1
Entrez,  Source
heme oxygenase (decycling) 151180.3400.1415No
51IGFBP1NAIGFBP1
Entrez,  Source
insulin-like growth factor binding protein 151280.3390.1433No
52ATP7ANAATP7A
Entrez,  Source
ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)52480.3270.1389No
53PFKFB3NAPFKFB3
Entrez,  Source
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 354260.3100.1311No
54SLC2A1NASLC2A1
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 154580.3070.1315No
55TIPARPNATIPARP
Entrez,  Source
TCDD-inducible poly(ADP-ribose) polymerase54780.3050.1324No
56GALK1NAGALK1
Entrez,  Source
galactokinase 155900.2960.1283No
57CHST3NACHST3
Entrez,  Source
carbohydrate (chondroitin 6) sulfotransferase 356450.2920.1272No
58HK2NAHK2
Entrez,  Source
hexokinase 257600.2820.1228No
59FBP1NAFBP1
Entrez,  Source
fructose-1,6-bisphosphatase 158090.2780.1220No
60MIFNAMIF
Entrez,  Source
macrophage migration inhibitory factor (glycosylation-inhibiting factor)59030.2690.1186No
61GCKNAGCK
Entrez,  Source
glucokinase (hexokinase 4, maturity onset diabetes of the young 2)59240.2680.1193No
62CASP6NACASP6
Entrez,  Source
caspase 6, apoptosis-related cysteine peptidase64280.2270.0928No
63DPYSL4NADPYSL4
Entrez,  Source
dihydropyrimidinase-like 465780.2130.0860No
64B3GALT6NAB3GALT6
Entrez,  Source
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 668790.1890.0706No
65SIAH2NASIAH2
Entrez,  Source
seven in absentia homolog 2 (Drosophila)69520.1830.0678No
66CA12NACA12
Entrez,  Source
carbonic anhydrase XII71250.1710.0594No
67PHKG1NAPHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)71320.1710.0602No
68CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)75230.1430.0394No
69BRS3NABRS3
Entrez,  Source
bombesin-like receptor 377980.1230.0250No
70KDELR3NAKDELR3
Entrez,  Source
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 378020.1220.0257No
71PGM2NAPGM2
Entrez,  Source
phosphoglucomutase 278380.1190.0245No
72VEGFANA79030.1150.0217No
73TESNATES
Entrez,  Source
testis derived transcript (3 LIM domains)82910.0860.0008No
74JMJD6NA83950.079-0.0044No
75GBE1NAGBE1
Entrez,  Source
glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV)84520.075-0.0070No
76NEDD4LNANEDD4L
Entrez,  Source
neural precursor cell expressed, developmentally down-regulated 4-like84800.073-0.0080No
77KLF6NAKLF6
Entrez,  Source
Kruppel-like factor 687570.054-0.0230No
78XPNPEP1NAXPNPEP1
Entrez,  Source
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble88680.046-0.0288No
79TPST2NATPST2
Entrez,  Source
tyrosylprotein sulfotransferase 289120.043-0.0309No
80NDST1NANDST1
Entrez,  Source
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 189360.041-0.0319No
81ENO2NAENO2
Entrez,  Source
enolase 2 (gamma, neuronal)89990.035-0.0351No
82ENO1NAENO1
Entrez,  Source
enolase 1, (alpha)92080.020-0.0466No
83GAPDHSNAGAPDHS
Entrez,  Source
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic93930.007-0.0568No
84PRDX5NAPRDX5
Entrez,  Source
peroxiredoxin 594700.003-0.0610No
85LALBANALALBA
Entrez,  Source
lactalbumin, alpha-95650.000-0.0662No
86GLRXNAGLRX
Entrez,  Source
glutaredoxin (thioltransferase)9744-0.001-0.0761No
87PDGFBNAPDGFB
Entrez,  Source
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)9832-0.008-0.0809No
88PGM1NAPGM1
Entrez,  Source
phosphoglucomutase 19960-0.017-0.0878No
89GPC4NAGPC4
Entrez,  Source
glypican 410040-0.021-0.0921No
90GPINAGPI
Entrez,  Source
glucose phosphate isomerase10110-0.027-0.0957No
91GAPDHNAGAPDH
Entrez,  Source
glyceraldehyde-3-phosphate dehydrogenase10205-0.031-0.1008No
92PKLRNAPKLR
Entrez,  Source
pyruvate kinase, liver and RBC10370-0.040-0.1096No
93VHLNAVHL
Entrez,  Source
von Hippel-Lindau tumor suppressor10397-0.042-0.1108No
94B4GALNT2NAB4GALNT2
Entrez,  Source
beta-1,4-N-acetyl-galactosaminyl transferase 210450-0.045-0.1134No
95HDLBPNAHDLBP
Entrez,  Source
high density lipoprotein binding protein (vigilin)10453-0.045-0.1132No
96ALDOBNAALDOB
Entrez,  Source
aldolase B, fructose-bisphosphate10946-0.074-0.1401No
97SLC6A6NASLC6A6
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, taurine), member 610974-0.076-0.1410No
98HAS1NAHAS1
Entrez,  Source
hyaluronan synthase 111166-0.089-0.1511No
99HOXB9NAHOXB9
Entrez,  Source
homeobox B911262-0.095-0.1557No
100SAP30NASAP30
Entrez,  Source
Sin3A-associated protein, 30kDa11354-0.102-0.1601No
101FOXO3NA11405-0.106-0.1622No
102PCK1NAPCK1
Entrez,  Source
phosphoenolpyruvate carboxykinase 1 (soluble)11490-0.114-0.1661No
103LDHANALDHA
Entrez,  Source
lactate dehydrogenase A11836-0.143-0.1843No
104ERRFI1NAERRFI1
Entrez,  Source
ERBB receptor feedback inhibitor 111903-0.148-0.1870No
105ANKZF1NAANKZF1
Entrez,  Source
ankyrin repeat and zinc finger domain containing 111918-0.149-0.1868No
106TPD52NATPD52
Entrez,  Source
tumor protein D5211937-0.150-0.1867No
107SLC37A4NASLC37A4
Entrez,  Source
solute carrier family 37 (glycerol-6-phosphate transporter), member 412154-0.169-0.1976No
108PYGMNAPYGM
Entrez,  Source
phosphorylase, glycogen; muscle (McArdle syndrome, glycogen storage disease type V)12209-0.174-0.1995No
109TMEM45ANATMEM45A
Entrez,  Source
transmembrane protein 45A12212-0.174-0.1984No
110PGFNAPGF
Entrez,  Source
placental growth factor, vascular endothelial growth factor-related protein12272-0.179-0.2005No
111RORANARORA
Entrez,  Source
RAR-related orphan receptor A12379-0.189-0.2051No
112CHST2NACHST2
Entrez,  Source
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 212453-0.197-0.2079No
113BGNNABGN
Entrez,  Source
biglycan12475-0.199-0.2077No
114GRHPRNAGRHPR
Entrez,  Source
glyoxylate reductase/hydroxypyruvate reductase12477-0.199-0.2064No
115WSB1NAWSB1
Entrez,  Source
WD repeat and SOCS box-containing 112602-0.210-0.2119No
116HEXANAHEXA
Entrez,  Source
hexosaminidase A (alpha polypeptide)12704-0.219-0.2160No
117LDHCNALDHC
Entrez,  Source
lactate dehydrogenase C12974-0.243-0.2294No
118STC2NASTC2
Entrez,  Source
stanniocalcin 212988-0.244-0.2285No
119KIF5ANAKIF5A
Entrez,  Source
kinesin family member 5A13323-0.274-0.2452No
120IER3NAIER3
Entrez,  Source
immediate early response 313360-0.277-0.2453No
121AKAP12NAAKAP12
Entrez,  Source
A kinase (PRKA) anchor protein (gravin) 1213511-0.293-0.2517No
122RBPJNA13620-0.305-0.2557No
123BTG1NABTG1
Entrez,  Source
B-cell translocation gene 1, anti-proliferative13694-0.311-0.2577No
124EFNA1NAEFNA1
Entrez,  Source
ephrin-A113734-0.314-0.2577No
125GYS1NAGYS1
Entrez,  Source
glycogen synthase 1 (muscle)13746-0.316-0.2562No
126DUSP1NADUSP1
Entrez,  Source
dual specificity phosphatase 113763-0.317-0.2550No
127EFNA3NAEFNA3
Entrez,  Source
ephrin-A313839-0.325-0.2570No
128SRPXNASRPX
Entrez,  Source
sushi-repeat-containing protein, X-linked13926-0.333-0.2595No
129TPI1NATPI1
Entrez,  Source
triosephosphate isomerase 113969-0.341-0.2596No
130CAV1NACAV1
Entrez,  Source
caveolin 1, caveolae protein, 22kDa13996-0.345-0.2587No
131STBD1NA14072-0.354-0.2605No
132CXCR4NACXCR4
Entrez,  Source
chemokine (C-X-C motif) receptor 414131-0.361-0.2613No
133BCL2NABCL2
Entrez,  Source
B-cell CLL/lymphoma 214397-0.390-0.2734No
134FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog14425-0.395-0.2722No
135TGFB3NATGFB3
Entrez,  Source
transforming growth factor, beta 314478-0.403-0.2724No
136UGP2NAUGP2
Entrez,  Source
UDP-glucose pyrophosphorylase 214539-0.411-0.2730No
137HS3ST1NAHS3ST1
Entrez,  Source
heparan sulfate (glucosamine) 3-O-sulfotransferase 114551-0.413-0.2708No
138STC1NASTC1
Entrez,  Source
stanniocalcin 114600-0.419-0.2707No
139TKTL1NATKTL1
Entrez,  Source
transketolase-like 114700-0.429-0.2733No
140FAM162ANA15085-0.486-0.2914No
141PFKLNAPFKL
Entrez,  Source
phosphofructokinase, liver15122-0.492-0.2901No
142RRAGDNARRAGD
Entrez,  Source
Ras-related GTP binding D15141-0.494-0.2878No
143ZNF292NAZNF292
Entrez,  Source
zinc finger protein 29215275-0.513-0.2918No
144PGK1NAPGK1
Entrez,  Source
phosphoglycerate kinase 115295-0.515-0.2894No
145EDN2NAEDN2
Entrez,  Source
endothelin 215438-0.539-0.2936No
146SLC2A3NASLC2A3
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 315473-0.547-0.2919No
147CPNACP
Entrez,  Source
ceruloplasmin (ferroxidase)15638-0.579-0.2971No
148SLC2A5NASLC2A5
Entrez,  Source
solute carrier family 2 (facilitated glucose/fructose transporter), member 515641-0.580-0.2933No
149PLIN2NA15679-0.586-0.2914No
150ILVBLNAILVBL
Entrez,  Source
ilvB (bacterial acetolactate synthase)-like15697-0.589-0.2884No
151S100A4NAS100A4
Entrez,  Source
S100 calcium binding protein A415715-0.591-0.2854No
152SCARB1NASCARB1
Entrez,  Source
scavenger receptor class B, member 115938-0.640-0.2934No
153KDM3ANA15952-0.643-0.2898No
154KLF7NAKLF7
Entrez,  Source
Kruppel-like factor 7 (ubiquitous)15995-0.655-0.2878No
155GAANAGAA
Entrez,  Source
glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II)16006-0.657-0.2839No
156SLC25A1NASLC25A1
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 116054-0.669-0.2820No
157IGFBP3NAIGFBP3
Entrez,  Source
insulin-like growth factor binding protein 316100-0.681-0.2800No
158NFIL3NANFIL3
Entrez,  Source
nuclear factor, interleukin 3 regulated16520-0.802-0.2979No
159PAMNAPAM
Entrez,  Source
peptidylglycine alpha-amidating monooxygenase16641-0.835-0.2990No
160SDC3NASDC3
Entrez,  Source
syndecan 3 (N-syndecan)16691-0.851-0.2960No
161CDKN1BNACDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)16862-0.909-0.2993No
162LOXNALOX
Entrez,  Source
lysyl oxidase17068-1.000-0.3040Yes
163PIM1NAPIM1
Entrez,  Source
pim-1 oncogene17087-1.007-0.2982Yes
164AMPD3NAAMPD3
Entrez,  Source
adenosine monophosphate deaminase (isoform E)17174-1.046-0.2960Yes
165PNRC1NAPNRC1
Entrez,  Source
proline-rich nuclear receptor coactivator 117226-1.076-0.2916Yes
166PGAM2NAPGAM2
Entrez,  Source
phosphoglycerate mutase 2 (muscle)17299-1.118-0.2881Yes
167VLDLRNAVLDLR
Entrez,  Source
very low density lipoprotein receptor17333-1.141-0.2823Yes
168DDIT4NADDIT4
Entrez,  Source
DNA-damage-inducible transcript 417443-1.212-0.2802Yes
169PDK1NAPDK1
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 117491-1.251-0.2744Yes
170KLHL24NAKLHL24
Entrez,  Source
kelch-like 24 (Drosophila)17524-1.275-0.2676Yes
171MXI1NAMXI1
Entrez,  Source
MAX interactor 117530-1.279-0.2593Yes
172CDKN1CNACDKN1C
Entrez,  Source
cyclin-dependent kinase inhibitor 1C (p57, Kip2)17588-1.334-0.2535Yes
173NDRG1NANDRG1
Entrez,  Source
N-myc downstream regulated gene 117599-1.346-0.2450Yes
174INHANAINHA
Entrez,  Source
inhibin, alpha17682-1.450-0.2398Yes
175IRS2NAIRS2
Entrez,  Source
insulin receptor substrate 217690-1.460-0.2304Yes
176LXNNALXN
Entrez,  Source
latexin17694-1.465-0.2208Yes
177SULT2B1NASULT2B1
Entrez,  Source
sulfotransferase family, cytosolic, 2B, member 117782-1.584-0.2150Yes
178BNIP3LNABNIP3L
Entrez,  Source
BCL2/adenovirus E1B 19kDa interacting protein 3-like17802-1.619-0.2051Yes
179PPARGC1ANAPPARGC1A
Entrez,  Source
peroxisome proliferative activated receptor, gamma, coactivator 1, alpha17803-1.623-0.1942Yes
180ALDOCNAALDOC
Entrez,  Source
aldolase C, fructose-bisphosphate17829-1.686-0.1843Yes
181HK1NAHK1
Entrez,  Source
hexokinase 117874-1.787-0.1747Yes
182PPP1R3CNAPPP1R3C
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 3C17881-1.803-0.1630Yes
183PRKCANAPRKCA
Entrez,  Source
protein kinase C, alpha17892-1.832-0.1512Yes
184SELENBP1NASELENBP1
Entrez,  Source
selenium binding protein 117916-1.900-0.1397Yes
185TGFBINATGFBI
Entrez,  Source
transforming growth factor, beta-induced, 68kDa17950-2.031-0.1279Yes
186DTNANADTNA
Entrez,  Source
dystrobrevin, alpha18011-2.353-0.1154Yes
187CCNG2NACCNG2
Entrez,  Source
cyclin G218022-2.397-0.0999Yes
188PDK3NAPDK3
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 318055-2.595-0.0842Yes
189ENO3NAENO3
Entrez,  Source
enolase 3 (beta, muscle)18098-2.969-0.0666Yes
190WISP2NAWISP2
Entrez,  Source
WNT1 inducible signaling pathway protein 218101-3.015-0.0465Yes
191AK4NA18140-3.687-0.0238Yes
192DCNNADCN
Entrez,  Source
decorin18141-3.7630.0014Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_HYPOXIA   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_HYPOXIA: Random ES distribution   
Gene set null distribution of ES for HALLMARK_HYPOXIA