Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_HEME_METABOLISM
Enrichment Score (ES)-0.29684055
Normalized Enrichment Score (NES)-1.2585589
Nominal p-value0.041666668
FDR q-value0.12657943
FWER p-Value0.748
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_HEME_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1RBM38NARBM38
Entrez,  Source
RNA binding motif protein 383361.864-0.0010No
2SLC30A1NASLC30A1
Entrez,  Source
solute carrier family 30 (zinc transporter), member 16031.411-0.0024No
3SLC10A3NASLC10A3
Entrez,  Source
solute carrier family 10 (sodium/bile acid cotransporter family), member 36121.4060.0105No
4SMOXNASMOX
Entrez,  Source
spermine oxidase7001.3250.0183No
5MPP1NAMPP1
Entrez,  Source
membrane protein, palmitoylated 1, 55kDa7041.3210.0307No
6GCLMNAGCLM
Entrez,  Source
glutamate-cysteine ligase, modifier subunit8121.2380.0365No
7ASNSNAASNS
Entrez,  Source
asparagine synthetase8271.2250.0474No
8SLC25A37NASLC25A37
Entrez,  Source
solute carrier family 25, member 379801.1310.0497No
9KLF3NAKLF3
Entrez,  Source
Kruppel-like factor 3 (basic)11271.0540.0516No
10OSBP2NAOSBP2
Entrez,  Source
oxysterol binding protein 211321.0520.0613No
11CCND3NACCND3
Entrez,  Source
cyclin D313470.9640.0586No
12SLC6A9NASLC6A9
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, glycine), member 913580.9610.0672No
13MAP2K3NAMAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 313730.9550.0755No
14IGSF3NAIGSF3
Entrez,  Source
immunoglobulin superfamily, member 315430.8980.0746No
15SLC30A10NASLC30A10
Entrez,  Source
solute carrier family 30, member 1015550.8940.0825No
16BMP2KNABMP2K
Entrez,  Source
BMP2 inducible kinase16840.8560.0835No
17ARL2BPNAARL2BP
Entrez,  Source
ADP-ribosylation factor-like 2 binding protein17110.8470.0901No
18CTSENACTSE
Entrez,  Source
cathepsin E17470.8390.0961No
19PDZK1IP1NAPDZK1IP1
Entrez,  Source
PDZK1 interacting protein 118630.8160.0975No
20H1F0NAH1F0
Entrez,  Source
H1 histone family, member 019440.7990.1006No
21ADD2NAADD2
Entrez,  Source
adducin 2 (beta)19460.7990.1082No
22NEK7NANEK7
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 720580.7750.1094No
23NFE2L1NANFE2L1
Entrez,  Source
nuclear factor (erythroid-derived 2)-like 121230.7610.1130No
24NR3C1NANR3C1
Entrez,  Source
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)22350.7360.1138No
25LRP10NALRP10
Entrez,  Source
low density lipoprotein receptor-related protein 1024190.6990.1103No
26GCLCNAGCLC
Entrez,  Source
glutamate-cysteine ligase, catalytic subunit24580.6930.1148No
27PIGQNAPIGQ
Entrez,  Source
phosphatidylinositol glycan anchor biosynthesis, class Q25710.6710.1149No
28BSGNABSG
Entrez,  Source
basigin (Ok blood group)28870.6160.1033No
29SLC7A11NASLC7A11
Entrez,  Source
solute carrier family 7, (cationic amino acid transporter, y+ system) member 1129680.6010.1045No
30LMO2NALMO2
Entrez,  Source
LIM domain only 2 (rhombotin-like 1)30230.5920.1072No
31ERMAPNAERMAP
Entrez,  Source
erythroblast membrane-associated protein (Scianna blood group)30340.5910.1122No
32TMEM9BNATMEM9B
Entrez,  Source
TMEM9 domain family, member B31630.5720.1105No
33FOXJ2NAFOXJ2
Entrez,  Source
forkhead box J231980.5680.1140No
34XKNAXK
Entrez,  Source
X-linked Kx blood group (McLeod syndrome)33330.5460.1118No
35CASTNACAST
Entrez,  Source
calpastatin35230.5200.1062No
36HTRA2NAHTRA2
Entrez,  Source
HtrA serine peptidase 236110.5090.1062No
37GMPSNAGMPS
Entrez,  Source
guanine monphosphate synthetase36200.5090.1106No
38FN3KNAFN3K
Entrez,  Source
fructosamine 3 kinase36810.4990.1120No
39RHCENARHCE
Entrez,  Source
Rh blood group, CcEe antigens37580.4900.1124No
40P4HA2NAP4HA2
Entrez,  Source
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II42170.4330.0911No
41TRIM58NATRIM58
Entrez,  Source
tripartite motif-containing 5842310.4310.0944No
42RAD23ANARAD23A
Entrez,  Source
RAD23 homolog A (S. cerevisiae)43100.4210.0941No
43CLIC2NACLIC2
Entrez,  Source
chloride intracellular channel 244690.4030.0891No
44KHNYNNA46490.3870.0829No
45SYNJ1NASYNJ1
Entrez,  Source
synaptojanin 146850.3850.0846No
46TRIM10NATRIM10
Entrez,  Source
tripartite motif-containing 1049480.3560.0734No
47CIR1NA49620.3550.0760No
48CPOXNACPOX
Entrez,  Source
coproporphyrinogen oxidase50020.3520.0772No
49GYPENAGYPE
Entrez,  Source
glycophorin E50160.3500.0798No
50PQLC1NAPQLC1
Entrez,  Source
PQ loop repeat containing 150450.3460.0815No
51CTNSNACTNS
Entrez,  Source
cystinosis, nephropathic52380.3280.0740No
52USP15NAUSP15
Entrez,  Source
ubiquitin specific peptidase 1552400.3280.0770No
53OPTNNAOPTN
Entrez,  Source
optineurin52600.3260.0791No
54SLC22A4NASLC22A4
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 453550.3170.0769No
55BTRCNABTRC
Entrez,  Source
beta-transducin repeat containing53620.3160.0795No
56ATG4ANAATG4A
Entrez,  Source
ATG4 autophagy related 4 homolog A (S. cerevisiae)53950.3130.0807No
57RHDNARHD
Entrez,  Source
Rh blood group, D antigen54480.3080.0808No
58SLC2A1NASLC2A1
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 154580.3070.0832No
59PPP2R5BNAPPP2R5B
Entrez,  Source
protein phosphatase 2, regulatory subunit B (B56), beta isoform56840.2880.0734No
60E2F2NAE2F2
Entrez,  Source
E2F transcription factor 257270.2840.0738No
61MINPP1NAMINPP1
Entrez,  Source
multiple inositol polyphosphate histidine phosphatase, 158100.2770.0718No
62MFHAS1NAMFHAS1
Entrez,  Source
malignant fibrous histiocytoma amplified sequence 158290.2760.0734No
63HMBSNAHMBS
Entrez,  Source
hydroxymethylbilane synthase58650.2720.0741No
64TOP1NATOP1
Entrez,  Source
topoisomerase (DNA) I58950.2700.0750No
65ENDOD1NAENDOD1
Entrez,  Source
endonuclease domain containing 159870.2650.0725No
66HBBNAHBB
Entrez,  Source
hemoglobin, beta60250.2620.0729No
67HTATIP2NAHTATIP2
Entrez,  Source
HIV-1 Tat interactive protein 2, 30kDa60510.2590.0740No
68PGLSNAPGLS
Entrez,  Source
6-phosphogluconolactonase60620.2580.0759No
69ACSL6NAACSL6
Entrez,  Source
acyl-CoA synthetase long-chain family member 661700.2480.0723No
70BLVRANABLVRA
Entrez,  Source
biliverdin reductase A62540.2410.0700No
71NUDT4NANUDT4
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 462830.2380.0707No
72MKRN1NAMKRN1
Entrez,  Source
makorin, ring finger protein, 166220.2100.0538No
73ALDH1L1NAALDH1L1
Entrez,  Source
aldehyde dehydrogenase 1 family, member L166660.2060.0534No
74BLVRBNABLVRB
Entrez,  Source
biliverdin reductase B (flavin reductase (NADPH))68450.1920.0453No
75SLC25A38NASLC25A38
Entrez,  Source
solute carrier family 25, member 3869560.1830.0410No
76MARK3NAMARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 370930.1750.0350No
77RCL1NARCL1
Entrez,  Source
RNA terminal phosphate cyclase-like 171510.1690.0335No
78HBDNAHBD
Entrez,  Source
hemoglobin, delta71830.1670.0333No
79DCAF10NA72180.1660.0330No
80VEZF1NAVEZF1
Entrez,  Source
vascular endothelial zinc finger 174680.1460.0206No
81GYPBNAGYPB
Entrez,  Source
glycophorin B (MNS blood group)76820.1320.0100No
82ADIPOR1NAADIPOR1
Entrez,  Source
adiponectin receptor 177410.1270.0079No
83HDGFNAHDGF
Entrez,  Source
hepatoma-derived growth factor (high-mobility group protein 1-like)78090.1220.0054No
84ICAM4NAICAM4
Entrez,  Source
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)79020.1150.0014No
85ACP5NAACP5
Entrez,  Source
acid phosphatase 5, tartrate resistant79080.1140.0022No
86RBM5NARBM5
Entrez,  Source
RNA binding motif protein 579950.108-0.0016No
87SLC4A1NASLC4A1
Entrez,  Source
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)80230.105-0.0021No
88ATP6V0A1NAATP6V0A1
Entrez,  Source
ATPase, H+ transporting, lysosomal V0 subunit a180340.105-0.0017No
89TAL1NATAL1
Entrez,  Source
T-cell acute lymphocytic leukemia 180740.101-0.0029No
90GAPVD1NAGAPVD1
Entrez,  Source
GTPase activating protein and VPS9 domains 183530.082-0.0176No
91SDCBPNASDCBP
Entrez,  Source
syndecan binding protein (syntenin)84990.072-0.0249No
92MBOAT2NAMBOAT2
Entrez,  Source
membrane bound O-acyltransferase domain containing 289600.038-0.0502No
93DAAM1NADAAM1
Entrez,  Source
dishevelled associated activator of morphogenesis 193590.011-0.0722No
94UROSNAUROS
Entrez,  Source
uroporphyrinogen III synthase (congenital erythropoietic porphyria)94490.004-0.0771No
95CA2NACA2
Entrez,  Source
carbonic anhydrase II95100.000-0.0804No
96AHSPNA95450.000-0.0823No
97HBQ1NAHBQ1
Entrez,  Source
hemoglobin, theta 196010.000-0.0854No
98PRDX2NAPRDX2
Entrez,  Source
peroxiredoxin 210009-0.018-0.1079No
99DCUN1D1NADCUN1D1
Entrez,  Source
DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)10252-0.035-0.1210No
100CA1NACA1
Entrez,  Source
carbonic anhydrase I10303-0.039-0.1234No
101CDC27NACDC27
Entrez,  Source
cell division cycle 2710327-0.039-0.1243No
102TYRNATYR
Entrez,  Source
tyrosinase (oculocutaneous albinism IA)10464-0.046-0.1314No
103FBXO7NAFBXO7
Entrez,  Source
F-box protein 710513-0.049-0.1337No
104ISCA1NA10549-0.051-0.1351No
105TCEA1NATCEA1
Entrez,  Source
transcription elongation factor A (SII), 110553-0.051-0.1348No
106URODNAUROD
Entrez,  Source
uroporphyrinogen decarboxylase10572-0.052-0.1353No
107RIOK3NARIOK3
Entrez,  Source
RIO kinase 3 (yeast)10627-0.056-0.1378No
108XPO7NAXPO7
Entrez,  Source
exportin 710707-0.061-0.1416No
109FBXO9NAFBXO9
Entrez,  Source
F-box protein 910930-0.073-0.1533No
110NCOA4NANCOA4
Entrez,  Source
nuclear receptor coactivator 411050-0.081-0.1591No
111TRAK2NATRAK2
Entrez,  Source
trafficking protein, kinesin binding 211158-0.089-0.1642No
112EPB41NAEPB41
Entrez,  Source
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)11192-0.091-0.1652No
113HIST1H4CNAHIST1H4C
Entrez,  Source
histone cluster 1, H4c11248-0.095-0.1673No
114HEBP1NAHEBP1
Entrez,  Source
heme binding protein 111259-0.095-0.1670No
115ADD1NAADD1
Entrez,  Source
adducin 1 (alpha)11353-0.102-0.1712No
116FOXO3NA11405-0.106-0.1730No
117AQP3NAAQP3
Entrez,  Source
aquaporin 3 (Gill blood group)11508-0.116-0.1776No
118PSMD9NAPSMD9
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 911527-0.117-0.1775No
119NARFNANARF
Entrez,  Source
nuclear prelamin A recognition factor11718-0.133-0.1868No
120UBAC1NA11723-0.133-0.1858No
121MARCH2NAMARCH2
Entrez,  Source
membrane-associated ring finger (C3HC4) 211738-0.135-0.1853No
122ANK1NAANK1
Entrez,  Source
ankyrin 1, erythrocytic11743-0.135-0.1842No
123PICALMNAPICALM
Entrez,  Source
phosphatidylinositol binding clathrin assembly protein11967-0.153-0.1952No
124ABCG2NAABCG2
Entrez,  Source
ATP-binding cassette, sub-family G (WHITE), member 212063-0.161-0.1989No
125EPB42NAEPB42
Entrez,  Source
erythrocyte membrane protein band 4.212237-0.176-0.2069No
126GYPCNAGYPC
Entrez,  Source
glycophorin C (Gerbich blood group)12549-0.206-0.2222No
127GLRX5NAGLRX5
Entrez,  Source
glutaredoxin 5 homolog (S. cerevisiae)12636-0.213-0.2250No
128KLF1NAKLF1
Entrez,  Source
Kruppel-like factor 1 (erythroid)12670-0.217-0.2247No
129BACH1NABACH1
Entrez,  Source
BTB and CNC homology 1, basic leucine zipper transcription factor 112817-0.228-0.2307No
130FBXO34NAFBXO34
Entrez,  Source
F-box protein 3412927-0.238-0.2345No
131ALAS2NAALAS2
Entrez,  Source
aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia)13069-0.250-0.2400No
132TSPO2NA13187-0.262-0.2440No
133FTCDNAFTCD
Entrez,  Source
formiminotransferase cyclodeaminase13358-0.277-0.2508No
134BPGMNABPGM
Entrez,  Source
2,3-bisphosphoglycerate mutase13410-0.283-0.2510No
135EZH1NAEZH1
Entrez,  Source
enhancer of zeste homolog 1 (Drosophila)13536-0.295-0.2551No
136ARHGEF12NAARHGEF12
Entrez,  Source
Rho guanine nucleotide exchange factor (GEF) 1213542-0.295-0.2526No
137UCP2NAUCP2
Entrez,  Source
uncoupling protein 2 (mitochondrial, proton carrier)13632-0.305-0.2546No
138GDE1NA13825-0.323-0.2623No
139CCDC28ANACCDC28A
Entrez,  Source
coiled-coil domain containing 28A13841-0.325-0.2600No
140RAP1GAPNARAP1GAP
Entrez,  Source
RAP1 GTPase activating protein13910-0.331-0.2606No
141AGPAT4NAAGPAT4
Entrez,  Source
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)13981-0.342-0.2613No
142EIF2AK1NAEIF2AK1
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 114028-0.348-0.2605No
143MYL4NAMYL4
Entrez,  Source
myosin, light chain 4, alkali; atrial, embryonic14041-0.351-0.2579No
144TNRC6BNATNRC6B
Entrez,  Source
trinucleotide repeat containing 6B14257-0.374-0.2663No
145DCAF11NA14492-0.404-0.2754No
146CTSBNACTSB
Entrez,  Source
cathepsin B14594-0.418-0.2771No
147GATA1NAGATA1
Entrez,  Source
GATA binding protein 1 (globin transcription factor 1)14628-0.421-0.2749No
148HAGHNAHAGH
Entrez,  Source
hydroxyacylglutathione hydrolase14741-0.436-0.2770No
149CDR2NACDR2
Entrez,  Source
cerebellar degeneration-related protein 2, 62kDa14773-0.440-0.2746No
150ELL2NAELL2
Entrez,  Source
elongation factor, RNA polymerase II, 214895-0.461-0.2769No
151EPORNAEPOR
Entrez,  Source
erythropoietin receptor14902-0.462-0.2729No
152LPIN2NALPIN2
Entrez,  Source
lipin 215072-0.485-0.2776No
153ABCB6NAABCB6
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 615208-0.504-0.2804No
154TMCC2NATMCC2
Entrez,  Source
transmembrane and coiled-coil domain family 215390-0.531-0.2854No
155SEC14L1NASEC14L1
Entrez,  Source
SEC14-like 1 (S. cerevisiae)15422-0.536-0.2820No
156LAMP2NALAMP2
Entrez,  Source
lysosomal-associated membrane protein 215452-0.543-0.2785No
157RNF19ANA15549-0.561-0.2785No
158SPTA1NASPTA1
Entrez,  Source
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)15828-0.615-0.2881No
159RNF123NARNF123
Entrez,  Source
ring finger protein 12315986-0.653-0.2906Yes
160FAM46CNAFAM46C
Entrez,  Source
family with sequence similarity 46, member C15997-0.656-0.2850Yes
161SLC11A2NASLC11A2
Entrez,  Source
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 216074-0.674-0.2828Yes
162CLCN3NACLCN3
Entrez,  Source
chloride channel 316143-0.691-0.2800Yes
163PPOXNAPPOX
Entrez,  Source
protoporphyrinogen oxidase16242-0.718-0.2786Yes
164TNS1NATNS1
Entrez,  Source
tensin 116276-0.727-0.2736Yes
165SLC6A8NASLC6A8
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, creatine), member 816278-0.728-0.2667Yes
166ALADNAALAD
Entrez,  Source
aminolevulinate, delta-, dehydratase16371-0.755-0.2646Yes
167C3NAC3
Entrez,  Source
complement component 316387-0.761-0.2582Yes
168TSPAN5NATSPAN5
Entrez,  Source
tetraspanin 516393-0.762-0.2513Yes
169GYPANAGYPA
Entrez,  Source
glycophorin A (MNS blood group)17040-0.989-0.2778Yes
170CATNACAT
Entrez,  Source
catalase17167-1.043-0.2749Yes
171SPTBNASPTB
Entrez,  Source
spectrin, beta, erythrocytic (includes spherocytosis, clinical type I)17221-1.072-0.2677Yes
172FECHNAFECH
Entrez,  Source
ferrochelatase (protoporphyria)17254-1.091-0.2591Yes
173TFDP2NATFDP2
Entrez,  Source
transcription factor Dp-2 (E2F dimerization partner 2)17258-1.096-0.2488Yes
174ALDH6A1NAALDH6A1
Entrez,  Source
aldehyde dehydrogenase 6 family, member A117307-1.122-0.2409Yes
175KELNAKEL
Entrez,  Source
Kell blood group, metallo-endopeptidase17455-1.223-0.2374Yes
176TFRCNATFRC
Entrez,  Source
transferrin receptor (p90, CD71)17504-1.261-0.2281Yes
177SIDT2NASIDT2
Entrez,  Source
SID1 transmembrane family, member 217508-1.264-0.2163Yes
178YPEL5NAYPEL5
Entrez,  Source
yippee-like 5 (Drosophila)17515-1.270-0.2045Yes
179MXI1NAMXI1
Entrez,  Source
MAX interactor 117530-1.279-0.1931Yes
180NNTNANNT
Entrez,  Source
nicotinamide nucleotide transhydrogenase17666-1.433-0.1870Yes
181NFE2NANFE2
Entrez,  Source
nuclear factor (erythroid-derived 2), 45kDa17699-1.469-0.1748Yes
182MOSPD1NAMOSPD1
Entrez,  Source
motile sperm domain containing 117712-1.484-0.1614Yes
183KAT2BNA17749-1.536-0.1488Yes
184MGST3NAMGST3
Entrez,  Source
microsomal glutathione S-transferase 317763-1.551-0.1348Yes
185BNIP3LNABNIP3L
Entrez,  Source
BCL2/adenovirus E1B 19kDa interacting protein 3-like17802-1.619-0.1215Yes
186MOCOSNAMOCOS
Entrez,  Source
molybdenum cofactor sulfurase17807-1.633-0.1062Yes
187PCNAPC
Entrez,  Source
pyruvate carboxylase17856-1.750-0.0923Yes
188SELENBP1NASELENBP1
Entrez,  Source
selenium binding protein 117916-1.900-0.0775Yes
189RHAGNARHAG
Entrez,  Source
Rh-associated glycoprotein17952-2.033-0.0601Yes
190BTG2NABTG2
Entrez,  Source
BTG family, member 217959-2.061-0.0409Yes
191SNCANASNCA
Entrez,  Source
synuclein, alpha (non A4 component of amyloid precursor)18027-2.421-0.0216Yes
192BCAMNABCAM
Entrez,  Source
basal cell adhesion molecule (Lutheran blood group)18105-3.0860.0034Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_HEME_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_HEME_METABOLISM: Random ES distribution   
Gene set null distribution of ES for HALLMARK_HEME_METABOLISM