Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_G2M_CHECKPOINT
Enrichment Score (ES)-0.18590504
Normalized Enrichment Score (NES)-0.7874957
Nominal p-value0.9746032
FDR q-value0.9316346
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_G2M_CHECKPOINT   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MT2ANAMT2A
Entrez,  Source
metallothionein 2A2742.0860.0118No
2PMLNAPML
Entrez,  Source
promyelocytic leukemia3071.9560.0353No
3TGFB1NATGFB1
Entrez,  Source
transforming growth factor, beta 1 (Camurati-Engelmann disease)5931.4250.0380No
4BCL3NABCL3
Entrez,  Source
B-cell CLL/lymphoma 313000.9820.0114No
5SLC12A2NASLC12A2
Entrez,  Source
solute carrier family 12 (sodium/potassium/chloride transporters), member 213760.9530.0196No
6SMC2NASMC2
Entrez,  Source
structural maintenance of chromosomes 216490.8670.0157No
7HSPA8NAHSPA8
Entrez,  Source
heat shock 70kDa protein 816550.8660.0266No
8HMGA1NAHMGA1
Entrez,  Source
high mobility group AT-hook 116990.8500.0352No
9PRMT5NAPRMT5
Entrez,  Source
protein arginine methyltransferase 518520.8180.0374No
10ATF5NAATF5
Entrez,  Source
activating transcription factor 521090.7650.0330No
11E2F4NAE2F4
Entrez,  Source
E2F transcription factor 4, p107/p130-binding21180.7620.0425No
12ORC6NA23690.7080.0377No
13UPF1NAUPF1
Entrez,  Source
UPF1 regulator of nonsense transcripts homolog (yeast)25820.6700.0346No
14POLQNAPOLQ
Entrez,  Source
polymerase (DNA directed), theta28380.6250.0285No
15H2AFXNAH2AFX
Entrez,  Source
H2A histone family, member X28490.6230.0360No
16BRCA2NABRCA2
Entrez,  Source
breast cancer 2, early onset28550.6220.0438No
17CHMP1ANA29240.6090.0479No
18FBXO5NAFBXO5
Entrez,  Source
F-box protein 530090.5950.0510No
19FANCCNAFANCC
Entrez,  Source
Fanconi anemia, complementation group C31060.5810.0532No
20SUV39H1NASUV39H1
Entrez,  Source
suppressor of variegation 3-9 homolog 1 (Drosophila)31430.5760.0586No
21XPO1NAXPO1
Entrez,  Source
exportin 1 (CRM1 homolog, yeast)31690.5710.0646No
22TRAIPNATRAIP
Entrez,  Source
TRAF interacting protein32570.5580.0670No
23CDC6NACDC6
Entrez,  Source
CDC6 cell division cycle 6 homolog (S. cerevisiae)32790.5560.0730No
24G3BP1NA33760.5400.0747No
25SLC7A1NASLC7A1
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 134870.5240.0754No
26GSPT1NAGSPT1
Entrez,  Source
G1 to S phase transition 135300.5190.0798No
27CHAF1ANACHAF1A
Entrez,  Source
chromatin assembly factor 1, subunit A (p150)35550.5160.0851No
28RBM14NARBM14
Entrez,  Source
RNA binding motif protein 1436060.5100.0889No
29CDC25ANACDC25A
Entrez,  Source
cell division cycle 25A36710.5010.0918No
30DR1NADR1
Entrez,  Source
down-regulator of transcription 1, TBP-binding (negative cofactor 2)37850.4870.0919No
31MTF2NAMTF2
Entrez,  Source
metal response element binding transcription factor 238030.4850.0972No
32NCLNANCL
Entrez,  Source
nucleolin38260.4830.1022No
33ABL1NAABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 138890.4770.1049No
34AURKBNAAURKB
Entrez,  Source
aurora kinase B41030.4470.0989No
35MNAT1NAMNAT1
Entrez,  Source
menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)42540.4280.0961No
36CCND1NACCND1
Entrez,  Source
cyclin D144400.4070.0911No
37NASPNANASP
Entrez,  Source
nuclear autoantigenic sperm protein (histone-binding)44500.4050.0958No
38NOLC1NANOLC1
Entrez,  Source
nucleolar and coiled-body phosphoprotein 144880.4020.0989No
39CTCFNACTCF
Entrez,  Source
CCCTC-binding factor (zinc finger protein)45320.3990.1017No
40EZH2NAEZH2
Entrez,  Source
enhancer of zeste homolog 2 (Drosophila)45370.3990.1067No
41SQLENASQLE
Entrez,  Source
squalene epoxidase47880.3730.0976No
42INCENPNAINCENP
Entrez,  Source
inner centromere protein antigens 135/155kDa49020.3620.0960No
43DDX39ANA49590.3550.0975No
44BARD1NABARD1
Entrez,  Source
BRCA1 associated RING domain 150920.3420.0946No
45RASAL2NARASAL2
Entrez,  Source
RAS protein activator like 251430.3380.0962No
46RAD23BNARAD23B
Entrez,  Source
RAD23 homolog B (S. cerevisiae)52550.3270.0942No
47DTYMKNADTYMK
Entrez,  Source
deoxythymidylate kinase (thymidylate kinase)52590.3260.0983No
48STILNASTIL
Entrez,  Source
SCL/TAL1 interrupting locus52900.3240.1008No
49WRNNAWRN
Entrez,  Source
Werner syndrome54670.3060.0950No
50HUS1NAHUS1
Entrez,  Source
HUS1 checkpoint homolog (S. pombe)54730.3050.0987No
51ODC1NAODC1
Entrez,  Source
ornithine decarboxylase 154990.3030.1012No
52RAD54LNARAD54L
Entrez,  Source
RAD54-like (S. cerevisiae)56150.2940.0986No
53HIRANAHIRA
Entrez,  Source
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)56250.2940.1019No
54CDK4NACDK4
Entrez,  Source
cyclin-dependent kinase 456790.2880.1027No
55E2F2NAE2F2
Entrez,  Source
E2F transcription factor 257270.2840.1038No
56TOP1NATOP1
Entrez,  Source
topoisomerase (DNA) I58950.2700.0980No
57SMC1ANASMC1A
Entrez,  Source
structural maintenance of chromosomes 1A60200.2620.0945No
58NUMA1NANUMA1
Entrez,  Source
nuclear mitotic apparatus protein 160440.2600.0965No
59DBF4NADBF4
Entrez,  Source
DBF4 homolog (S. cerevisiae)60680.2570.0986No
60POLA2NAPOLA2
Entrez,  Source
polymerase (DNA directed), alpha 2 (70kD subunit)60900.2550.1007No
61E2F3NAE2F3
Entrez,  Source
E2F transcription factor 361480.2500.1008No
62RBL1NARBL1
Entrez,  Source
retinoblastoma-like 1 (p107)61840.2470.1020No
63TNPO2NATNPO2
Entrez,  Source
transportin 2 (importin 3, karyopherin beta 2b)62170.2440.1034No
64ORC5NA62190.2430.1065No
65DKC1NADKC1
Entrez,  Source
dyskeratosis congenita 1, dyskerin62850.2370.1060No
66CASP8AP2NACASP8AP2
Entrez,  Source
CASP8 associated protein 263130.2360.1075No
67SYNCRIPNASYNCRIP
Entrez,  Source
synaptotagmin binding, cytoplasmic RNA interacting protein63140.2360.1106No
68CCNFNACCNF
Entrez,  Source
cyclin F64260.2270.1073No
69ESPL1NAESPL1
Entrez,  Source
extra spindle poles like 1 (S. cerevisiae)64390.2260.1096No
70CDC20NACDC20
Entrez,  Source
CDC20 cell division cycle 20 homolog (S. cerevisiae)65010.2210.1091No
71MCM5NAMCM5
Entrez,  Source
MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)65270.2180.1105No
72STAG1NASTAG1
Entrez,  Source
stromal antigen 166200.2100.1081No
73KPNB1NAKPNB1
Entrez,  Source
karyopherin (importin) beta 166260.2090.1105No
74RPA2NARPA2
Entrez,  Source
replication protein A2, 32kDa67140.2020.1083No
75EWSR1NAEWSR1
Entrez,  Source
Ewing sarcoma breakpoint region 167430.2000.1093No
76LMNB1NALMNB1
Entrez,  Source
lamin B167640.1980.1108No
77CDKN2CNACDKN2C
Entrez,  Source
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)67940.1970.1117No
78CDC25BNACDC25B
Entrez,  Source
cell division cycle 25B69150.1860.1075No
79MCM2NAMCM2
Entrez,  Source
MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)69260.1850.1093No
80TFDP1NATFDP1
Entrez,  Source
transcription factor Dp-169940.1800.1079No
81SRSF10NA69980.1800.1101No
82HIF1ANAHIF1A
Entrez,  Source
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)72120.1660.1004No
83MYBL2NAMYBL2
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)-like 273290.1570.0960No
84NUP98NANUP98
Entrez,  Source
nucleoporin 98kDa76780.1320.0783No
85TMPONATMPO
Entrez,  Source
thymopoietin77420.1270.0764No
86KIF23NAKIF23
Entrez,  Source
kinesin family member 2378180.1210.0738No
87POLENAPOLE
Entrez,  Source
polymerase (DNA directed), epsilon78350.1200.0745No
88SFPQNASFPQ
Entrez,  Source
splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)78400.1190.0758No
89CDC7NACDC7
Entrez,  Source
CDC7 cell division cycle 7 (S. cerevisiae)79990.1080.0684No
90TRA2BNA81300.0970.0625No
91PDS5BNA84240.0770.0472No
92AMD1NAAMD1
Entrez,  Source
adenosylmethionine decarboxylase 184360.0760.0475No
93TLE3NATLE3
Entrez,  Source
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)84670.0740.0468No
94CUL1NACUL1
Entrez,  Source
cullin 184780.0730.0472No
95RPS6KA5NARPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 585610.0670.0435No
96NOTCH2NANOTCH2
Entrez,  Source
Notch homolog 2 (Drosophila)85650.0670.0442No
97PAPD7NA86290.0620.0415No
98HNRNPDNA87730.0520.0343No
99YTHDC1NAYTHDC1
Entrez,  Source
YTH domain containing 187920.0520.0339No
100MAPK14NAMAPK14
Entrez,  Source
mitogen-activated protein kinase 1488780.0450.0298No
101GINS2NAGINS2
Entrez,  Source
GINS complex subunit 2 (Psf2 homolog)88940.0440.0295No
102PLK4NAPLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)89140.0430.0290No
103HNRNPUNA91490.0240.0163No
104UCK2NAUCK2
Entrez,  Source
uridine-cytidine kinase 292280.0190.0122No
105DMDNADMD
Entrez,  Source
dystrophin (muscular dystrophy, Duchenne and Becker types)93280.0120.0069No
106CHEK1NACHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)94500.0040.0002No
107NUP50NANUP50
Entrez,  Source
nucleoporin 50kDa95070.000-0.0029No
108CKS1BNACKS1B
Entrez,  Source
CDC28 protein kinase regulatory subunit 1B9735-0.001-0.0155No
109PRIM2NA9771-0.004-0.0174No
110HMGN2NAHMGN2
Entrez,  Source
high-mobility group nucleosomal binding domain 29778-0.004-0.0177No
111MEIS1NAMEIS1
Entrez,  Source
Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)9897-0.012-0.0241No
112CCNT1NACCNT1
Entrez,  Source
cyclin T19919-0.014-0.0251No
113UBE2SNAUBE2S
Entrez,  Source
ubiquitin-conjugating enzyme E2S9949-0.016-0.0265No
114KIF11NAKIF11
Entrez,  Source
kinesin family member 1110053-0.022-0.0320No
115KPNA2NAKPNA2
Entrez,  Source
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)10129-0.028-0.0358No
116CDC27NACDC27
Entrez,  Source
cell division cycle 2710327-0.039-0.0462No
117EFNA5NAEFNA5
Entrez,  Source
ephrin-A510682-0.060-0.0652No
118ILF3NAILF3
Entrez,  Source
interleukin enhancer binding factor 3, 90kDa10811-0.066-0.0714No
119HOXC10NAHOXC10
Entrez,  Source
homeobox C1010977-0.076-0.0796No
120ODF2NAODF2
Entrez,  Source
outer dense fiber of sperm tails 211141-0.087-0.0876No
121SS18NASS18
Entrez,  Source
synovial sarcoma translocation, chromosome 1811226-0.093-0.0910No
122CCNA2NACCNA2
Entrez,  Source
cyclin A211343-0.101-0.0962No
123SAP30NASAP30
Entrez,  Source
Sin3A-associated protein, 30kDa11354-0.102-0.0954No
124CBX1NACBX1
Entrez,  Source
chromobox homolog 1 (HP1 beta homolog Drosophila )11372-0.103-0.0950No
125MEIS2NAMEIS2
Entrez,  Source
Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse)11384-0.104-0.0943No
126ARID4ANAARID4A
Entrez,  Source
AT rich interactive domain 4A (RBP1-like)11503-0.115-0.0993No
127SRSF1NA11517-0.116-0.0986No
128LBRNALBR
Entrez,  Source
lamin B receptor11610-0.123-0.1021No
129MCM3NAMCM3
Entrez,  Source
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)11663-0.128-0.1033No
130CDC45NA11682-0.130-0.1026No
131MCM6NAMCM6
Entrez,  Source
MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)11820-0.142-0.1084No
132PURANAPURA
Entrez,  Source
purine-rich element binding protein A11883-0.147-0.1100No
133TACC3NATACC3
Entrez,  Source
transforming, acidic coiled-coil containing protein 312097-0.163-0.1197No
134SNRPD1NASNRPD1
Entrez,  Source
small nuclear ribonucleoprotein D1 polypeptide 16kDa12116-0.166-0.1186No
135ATRXNAATRX
Entrez,  Source
alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)12122-0.167-0.1167No
136KIF22NAKIF22
Entrez,  Source
kinesin family member 2212173-0.171-0.1173No
137PLK1NAPLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)12400-0.191-0.1274No
138TROAPNATROAP
Entrez,  Source
trophinin associated protein (tastin)12424-0.194-0.1261No
139KIF15NAKIF15
Entrez,  Source
kinesin family member 1512500-0.201-0.1277No
140EXO1NAEXO1
Entrez,  Source
exonuclease 112853-0.230-0.1443No
141E2F1NAE2F1
Entrez,  Source
E2F transcription factor 113216-0.264-0.1610No
142BUB3NABUB3
Entrez,  Source
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)13263-0.269-0.1601No
143LIG3NALIG3
Entrez,  Source
ligase III, DNA, ATP-dependent13320-0.274-0.1597No
144KIF20BNA13575-0.298-0.1699No
145SMARCC1NASMARCC1
Entrez,  Source
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 113610-0.302-0.1679No
146SMAD3NASMAD3
Entrez,  Source
SMAD, mothers against DPP homolog 3 (Drosophila)13718-0.312-0.1698No
147BUB1NABUB1
Entrez,  Source
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)13719-0.312-0.1658No
148MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)13741-0.315-0.1628No
149KIF4ANAKIF4A
Entrez,  Source
kinesin family member 4A14011-0.346-0.1733No
150H2AFVNAH2AFV
Entrez,  Source
H2A histone family, member V14238-0.372-0.1811Yes
151MKI67NAMKI67
Entrez,  Source
antigen identified by monoclonal antibody Ki-6714279-0.377-0.1784Yes
152TPX2NATPX2
Entrez,  Source
TPX2, microtubule-associated, homolog (Xenopus laevis)14304-0.380-0.1748Yes
153CDK1NA14384-0.389-0.1742Yes
154KIF2CNAKIF2C
Entrez,  Source
kinesin family member 2C14496-0.404-0.1751Yes
155PAFAH1B1NAPAFAH1B1
Entrez,  Source
platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa14625-0.421-0.1768Yes
156PRPF4BNAPRPF4B
Entrez,  Source
PRP4 pre-mRNA processing factor 4 homolog B (yeast)14646-0.424-0.1724Yes
157SRSF2NA14780-0.442-0.1741Yes
158MAD2L1NAMAD2L1
Entrez,  Source
MAD2 mitotic arrest deficient-like 1 (yeast)14791-0.444-0.1689Yes
159TTKNATTK
Entrez,  Source
TTK protein kinase14952-0.469-0.1717Yes
160CUL5NACUL5
Entrez,  Source
cullin 515169-0.498-0.1773Yes
161KATNA1NAKATNA1
Entrez,  Source
katanin p60 (ATPase-containing) subunit A 115199-0.503-0.1724Yes
162CUL3NACUL3
Entrez,  Source
cullin 315387-0.531-0.1759Yes
163NDC80NA15432-0.538-0.1714Yes
164BIRC5NABIRC5
Entrez,  Source
baculoviral IAP repeat-containing 5 (survivin)15435-0.539-0.1645Yes
165SMC4NASMC4
Entrez,  Source
structural maintenance of chromosomes 415518-0.555-0.1619Yes
166CENPANACENPA
Entrez,  Source
centromere protein A15531-0.558-0.1554Yes
167SLC38A1NASLC38A1
Entrez,  Source
solute carrier family 38, member 115582-0.568-0.1508Yes
168MARCKSNAMARCKS
Entrez,  Source
myristoylated alanine-rich protein kinase C substrate15669-0.584-0.1480Yes
169H2AFZNAH2AFZ
Entrez,  Source
H2A histone family, member Z15685-0.587-0.1412Yes
170RAD21NARAD21
Entrez,  Source
RAD21 homolog (S. pombe)15874-0.627-0.1436Yes
171CUL4ANACUL4A
Entrez,  Source
cullin 4A16003-0.656-0.1422Yes
172RACGAP1NARACGAP1
Entrez,  Source
Rac GTPase activating protein 116022-0.661-0.1346Yes
173CKS2NACKS2
Entrez,  Source
CDC28 protein kinase regulatory subunit 216029-0.662-0.1264Yes
174AURKANAAURKA
Entrez,  Source
aurora kinase A16121-0.685-0.1226Yes
175TOP2ANATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa16265-0.724-0.1211Yes
176HMGB3NAHMGB3
Entrez,  Source
high-mobility group box 316337-0.743-0.1155Yes
177NEK2NANEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 216344-0.746-0.1061Yes
178KIF5BNAKIF5B
Entrez,  Source
kinesin family member 5B16346-0.747-0.0965Yes
179STMN1NASTMN1
Entrez,  Source
stathmin 1/oncoprotein 1816362-0.751-0.0876Yes
180HMMRNAHMMR
Entrez,  Source
hyaluronan-mediated motility receptor (RHAMM)16504-0.799-0.0851Yes
181CENPFNACENPF
Entrez,  Source
centromere protein F, 350/400ka (mitosin)16589-0.823-0.0791Yes
182FOXN3NA16769-0.877-0.0777Yes
183CENPENACENPE
Entrez,  Source
centromere protein E, 312kDa16807-0.890-0.0682Yes
184CDKN1BNACDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)16862-0.909-0.0595Yes
185HIST1H2BKNAHIST1H2BK
Entrez,  Source
histone cluster 1, H2bk17001-0.968-0.0546Yes
186NUSAP1NANUSAP1
Entrez,  Source
nucleolar and spindle associated protein 117054-0.992-0.0447Yes
187CCNB2NACCNB2
Entrez,  Source
cyclin B217059-0.994-0.0320Yes
188PBKNAPBK
Entrez,  Source
PDZ binding kinase17079-1.004-0.0200Yes
189PRC1NAPRC1
Entrez,  Source
protein regulator of cytokinesis 117157-1.036-0.0109Yes
190PTTG1NAPTTG1
Entrez,  Source
pituitary tumor-transforming 117216-1.070-0.0003Yes
191CDKN3NACDKN3
Entrez,  Source
cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)17564-1.309-0.0026Yes
192SLC7A5NASLC7A5
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 517569-1.3130.0141Yes
193EGFNAEGF
Entrez,  Source
epidermal growth factor (beta-urogastrone)17704-1.4720.0258Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_G2M_CHECKPOINT   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_G2M_CHECKPOINT: Random ES distribution   
Gene set null distribution of ES for HALLMARK_G2M_CHECKPOINT