Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_FATTY_ACID_METABOLISM
Enrichment Score (ES)-0.3745652
Normalized Enrichment Score (NES)-1.5498166
Nominal p-value0.0026455026
FDR q-value0.0302828
FWER p-Value0.093
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_FATTY_ACID_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1PTPRGNAPTPRG
Entrez,  Source
protein tyrosine phosphatase, receptor type, G2962.0120.0115No
2IL4I1NAIL4I1
Entrez,  Source
interleukin 4 induced 16661.3550.0098No
3S100A10NAS100A10
Entrez,  Source
S100 calcium binding protein A109691.1340.0088No
4PSME1NAPSME1
Entrez,  Source
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)10491.0960.0197No
5UGDHNAUGDH
Entrez,  Source
UDP-glucose dehydrogenase11791.0310.0268No
6HMGCS1NAHMGCS1
Entrez,  Source
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)12890.9850.0345No
7HSPH1NAHSPH1
Entrez,  Source
heat shock 105kDa/110kDa protein 113550.9620.0442No
8RDH16NARDH16
Entrez,  Source
retinol dehydrogenase 16 (all-trans)13890.9490.0556No
9VNN1NAVNN1
Entrez,  Source
vanin 124740.6900.0050No
10RETSATNARETSAT
Entrez,  Source
retinol saturase (all-trans-retinol 13,14-reductase)28020.630-0.0044No
11CBR3NACBR3
Entrez,  Source
carbonyl reductase 331680.571-0.0167No
12CELNACEL
Entrez,  Source
carboxyl ester lipase (bile salt-stimulated lipase)34430.530-0.0246No
13ALDOANAALDOA
Entrez,  Source
aldolase A, fructose-bisphosphate36790.499-0.0307No
14ECI1NA39060.474-0.0366No
15CA6NACA6
Entrez,  Source
carbonic anhydrase VI40190.459-0.0365No
16NCAPH2NANCAPH2
Entrez,  Source
non-SMC condensin II complex, subunit H240350.457-0.0310No
17CBR1NACBR1
Entrez,  Source
carbonyl reductase 141140.445-0.0291No
18NTHL1NANTHL1
Entrez,  Source
nth endonuclease III-like 1 (E. coli)43660.415-0.0373No
19CCDC58NACCDC58
Entrez,  Source
coiled-coil domain containing 5846310.390-0.0465No
20NBNNANBN
Entrez,  Source
nibrin47200.380-0.0461No
21CPOXNACPOX
Entrez,  Source
coproporphyrinogen oxidase50020.352-0.0568No
22MLYCDNAMLYCD
Entrez,  Source
malonyl-CoA decarboxylase50930.342-0.0571No
23ALDH3A1NAALDH3A1
Entrez,  Source
aldehyde dehydrogenase 3 family, memberA154340.309-0.0717No
24ODC1NAODC1
Entrez,  Source
ornithine decarboxylase 154990.303-0.0710No
25HSP90AA1NAHSP90AA1
Entrez,  Source
heat shock protein 90kDa alpha (cytosolic), class A member 156630.290-0.0760No
26CPT1ANACPT1A
Entrez,  Source
carnitine palmitoyltransferase 1A (liver)56940.287-0.0737No
27SLC22A5NASLC22A5
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 558310.275-0.0774No
28MIFNAMIF
Entrez,  Source
macrophage migration inhibitory factor (glycosylation-inhibiting factor)59030.269-0.0776No
29GPD2NAGPD2
Entrez,  Source
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)60060.263-0.0796No
30NSDHLNANSDHL
Entrez,  Source
NAD(P) dependent steroid dehydrogenase-like60540.259-0.0787No
31CYP4A11NACYP4A11
Entrez,  Source
cytochrome P450, family 4, subfamily A, polypeptide 1161300.251-0.0793No
32BLVRANABLVRA
Entrez,  Source
biliverdin reductase A62540.241-0.0828No
33SMSNASMS
Entrez,  Source
spermine synthase62950.237-0.0817No
34CA4NACA4
Entrez,  Source
carbonic anhydrase IV64030.228-0.0845No
35CRYZNACRYZ
Entrez,  Source
crystallin, zeta (quinone reductase)64400.226-0.0834No
36ACSL4NAACSL4
Entrez,  Source
acyl-CoA synthetase long-chain family member 464630.225-0.0815No
37MAOANAMAOA
Entrez,  Source
monoamine oxidase A65500.215-0.0833No
38YWHAHNAYWHAH
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide65800.213-0.0819No
39PRDX6NAPRDX6
Entrez,  Source
peroxiredoxin 666370.208-0.0821No
40IDH3GNAIDH3G
Entrez,  Source
isocitrate dehydrogenase 3 (NAD+) gamma67460.199-0.0853No
41RDH11NARDH11
Entrez,  Source
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)68210.194-0.0868No
42GABARAPL1NAGABARAPL1
Entrez,  Source
GABA(A) receptor-associated protein like 168680.190-0.0867No
43ACSL5NAACSL5
Entrez,  Source
acyl-CoA synthetase long-chain family member 569330.185-0.0877No
44LTC4SNALTC4S
Entrez,  Source
leukotriene C4 synthase69440.184-0.0857No
45SERINC1NASERINC1
Entrez,  Source
serine incorporator 173780.153-0.1076No
46D2HGDHNAD2HGDH
Entrez,  Source
D-2-hydroxyglutarate dehydrogenase74730.146-0.1108No
47BPHLNABPHL
Entrez,  Source
biphenyl hydrolase-like (serine hydrolase; breast epithelial mucin-associated antigen)79780.109-0.1372No
48EPHX1NAEPHX1
Entrez,  Source
epoxide hydrolase 1, microsomal (xenobiotic)82260.091-0.1497No
49DHCR24NADHCR24
Entrez,  Source
24-dehydrocholesterol reductase82330.091-0.1487No
50DLSTNADLST
Entrez,  Source
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)83900.080-0.1563No
51ACAA1NAACAA1
Entrez,  Source
acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase)86170.064-0.1679No
52CPT2NACPT2
Entrez,  Source
carnitine palmitoyltransferase II86520.061-0.1690No
53ENO2NAENO2
Entrez,  Source
enolase 2 (gamma, neuronal)89990.035-0.1877No
54HCCSNAHCCS
Entrez,  Source
holocytochrome c synthase (cytochrome c heme-lyase)92640.016-0.2021No
55GAPDHSNAGAPDHS
Entrez,  Source
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic93930.007-0.2091No
56UROSNAUROS
Entrez,  Source
uroporphyrinogen III synthase (congenital erythropoietic porphyria)94490.004-0.2121No
57CA2NACA2
Entrez,  Source
carbonic anhydrase II95100.000-0.2155No
58CIDEANACIDEA
Entrez,  Source
cell death-inducing DFFA-like effector a96700.000-0.2243No
59HSD17B10NA10055-0.023-0.2453No
60ADSLNAADSL
Entrez,  Source
adenylosuccinate lyase10094-0.025-0.2470No
61HSD17B11NA10104-0.026-0.2472No
62INMTNAINMT
Entrez,  Source
indolethylamine N-methyltransferase10247-0.034-0.2546No
63URODNAUROD
Entrez,  Source
uroporphyrinogen decarboxylase10572-0.052-0.2719No
64CD1DNACD1D
Entrez,  Source
CD1d molecule10589-0.053-0.2720No
65METAP1NAMETAP1
Entrez,  Source
methionyl aminopeptidase 110791-0.064-0.2823No
66HAO2NAHAO2
Entrez,  Source
hydroxyacid oxidase 2 (long chain)10859-0.069-0.2850No
67RAP1GDS1NARAP1GDS1
Entrez,  Source
RAP1, GTP-GDP dissociation stimulator 110965-0.076-0.2898No
68PCBD1NAPCBD1
Entrez,  Source
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)11371-0.103-0.3108No
69HSD17B7NAHSD17B7
Entrez,  Source
hydroxysteroid (17-beta) dehydrogenase 711676-0.130-0.3259No
70FASNNAFASN
Entrez,  Source
fatty acid synthase11717-0.133-0.3263No
71MDH2NAMDH2
Entrez,  Source
malate dehydrogenase 2, NAD (mitochondrial)11787-0.139-0.3282No
72LDHANALDHA
Entrez,  Source
lactate dehydrogenase A11836-0.143-0.3289No
73CYP1A1NACYP1A1
Entrez,  Source
cytochrome P450, family 1, subfamily A, polypeptide 111891-0.147-0.3298No
74ACOT8NAACOT8
Entrez,  Source
acyl-CoA thioesterase 811947-0.151-0.3308No
75G0S2NAG0S2
Entrez,  Source
G0/G1switch 211959-0.152-0.3293No
76ACSS1NAACSS1
Entrez,  Source
acyl-CoA synthetase short-chain family member 112088-0.163-0.3341No
77SUCLA2NASUCLA2
Entrez,  Source
succinate-CoA ligase, ADP-forming, beta subunit12175-0.171-0.3365No
78ADIPOR2NAADIPOR2
Entrez,  Source
adiponectin receptor 212436-0.196-0.3482No
79ECI2NA12467-0.198-0.3471No
80GRHPRNAGRHPR
Entrez,  Source
glyoxylate reductase/hydroxypyruvate reductase12477-0.199-0.3449No
81ME1NAME1
Entrez,  Source
malic enzyme 1, NADP(+)-dependent, cytosolic12526-0.204-0.3447No
82ALDH1A1NAALDH1A1
Entrez,  Source
aldehyde dehydrogenase 1 family, member A112537-0.205-0.3424No
83ACAA2NAACAA2
Entrez,  Source
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)12565-0.207-0.3411No
84BMPR1BNABMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB12634-0.213-0.3419No
85MGLLNAMGLL
Entrez,  Source
monoglyceride lipase12767-0.225-0.3461No
86HIBCHNAHIBCH
Entrez,  Source
3-hydroxyisobutyryl-Coenzyme A hydrolase12823-0.228-0.3460No
87APEX1NAAPEX1
Entrez,  Source
APEX nuclease (multifunctional DNA repair enzyme) 112984-0.244-0.3515No
88ELOVL5NAELOVL5
Entrez,  Source
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)13047-0.249-0.3514No
89GLULNAGLUL
Entrez,  Source
glutamate-ammonia ligase (glutamine synthetase)13049-0.249-0.3480No
90HMGCLNAHMGCL
Entrez,  Source
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)13133-0.256-0.3491No
91HMGCS2NAHMGCS2
Entrez,  Source
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)13152-0.258-0.3465No
92ECHS1NAECHS1
Entrez,  Source
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial13439-0.286-0.3584No
93SDHCNASDHC
Entrez,  Source
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa13605-0.301-0.3634No
94ERP29NAERP29
Entrez,  Source
endoplasmic reticulum protein 2913657-0.307-0.3620No
95ACAT2NAACAT2
Entrez,  Source
acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)13792-0.320-0.3650No
96OSTCNA13966-0.341-0.3698Yes
97ALDH9A1NAALDH9A1
Entrez,  Source
aldehyde dehydrogenase 9 family, member A113994-0.345-0.3665Yes
98AADATNAAADAT
Entrez,  Source
aminoadipate aminotransferase14053-0.352-0.3649Yes
99ACO2NAACO2
Entrez,  Source
aconitase 2, mitochondrial14158-0.364-0.3656Yes
100HSD17B4NAHSD17B4
Entrez,  Source
hydroxysteroid (17-beta) dehydrogenase 414216-0.369-0.3636Yes
101SUCLG2NASUCLG2
Entrez,  Source
succinate-CoA ligase, GDP-forming, beta subunit14250-0.373-0.3603Yes
102ACADVLNAACADVL
Entrez,  Source
acyl-Coenzyme A dehydrogenase, very long chain14350-0.385-0.3604Yes
103ALDH3A2NAALDH3A2
Entrez,  Source
aldehyde dehydrogenase 3 family, member A214517-0.407-0.3640Yes
104AQP7NAAQP7
Entrez,  Source
aquaporin 714574-0.416-0.3613Yes
105HADHNAHADH
Entrez,  Source
hydroxyacyl-Coenzyme A dehydrogenase14585-0.417-0.3561Yes
106GAD2NAGAD2
Entrez,  Source
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)14709-0.430-0.3569Yes
107ACADSNAACADS
Entrez,  Source
acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain14739-0.435-0.3525Yes
108PTSNAPTS
Entrez,  Source
6-pyruvoyltetrahydropterin synthase14761-0.438-0.3476Yes
109HSDL2NAHSDL2
Entrez,  Source
hydroxysteroid dehydrogenase like 214762-0.438-0.3415Yes
110UBE2L6NAUBE2L6
Entrez,  Source
ubiquitin-conjugating enzyme E2L 614820-0.450-0.3384Yes
111CRATNACRAT
Entrez,  Source
carnitine acetyltransferase14842-0.454-0.3333Yes
112ACOX1NAACOX1
Entrez,  Source
acyl-Coenzyme A oxidase 1, palmitoyl14870-0.458-0.3284Yes
113ACADLNAACADL
Entrez,  Source
acyl-Coenzyme A dehydrogenase, long chain14880-0.459-0.3225Yes
114SDHANASDHA
Entrez,  Source
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)14927-0.465-0.3186Yes
115FHNAFH
Entrez,  Source
fumarate hydratase15028-0.479-0.3175Yes
116PDHA1NAPDHA1
Entrez,  Source
pyruvate dehydrogenase (lipoamide) alpha 115056-0.483-0.3123Yes
117GCDHNAGCDH
Entrez,  Source
glutaryl-Coenzyme A dehydrogenase15065-0.485-0.3060Yes
118LGALS1NALGALS1
Entrez,  Source
lectin, galactoside-binding, soluble, 1 (galectin 1)15087-0.487-0.3004Yes
119PPARANAPPARA
Entrez,  Source
peroxisome proliferative activated receptor, alpha15161-0.497-0.2976Yes
120ADH7NAADH7
Entrez,  Source
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide15198-0.502-0.2926Yes
121ADH1CNAADH1C
Entrez,  Source
alcohol dehydrogenase 1C (class I), gamma polypeptide15278-0.513-0.2899Yes
122IDH1NAIDH1
Entrez,  Source
isocitrate dehydrogenase 1 (NADP+), soluble15361-0.527-0.2871Yes
123ACOT2NAACOT2
Entrez,  Source
acyl-CoA thioesterase 215407-0.533-0.2822Yes
124DLDNADLD
Entrez,  Source
dihydrolipoamide dehydrogenase15418-0.535-0.2753Yes
125REEP6NAREEP6
Entrez,  Source
receptor accessory protein 615569-0.566-0.2758Yes
126H2AFZNAH2AFZ
Entrez,  Source
H2A histone family, member Z15685-0.587-0.2740Yes
127MCEENAMCEE
Entrez,  Source
methylmalonyl CoA epimerase15857-0.622-0.2749Yes
128HADHBNAHADHB
Entrez,  Source
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit16132-0.688-0.2805Yes
129ALADNAALAD
Entrez,  Source
aminolevulinate, delta-, dehydratase16371-0.755-0.2833Yes
130EHHADHNAEHHADH
Entrez,  Source
enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase16508-0.801-0.2797Yes
131PDHBNAPDHB
Entrez,  Source
pyruvate dehydrogenase (lipoamide) beta16571-0.817-0.2718Yes
132SUCLG1NASUCLG1
Entrez,  Source
succinate-CoA ligase, GDP-forming, alpha subunit16597-0.825-0.2617Yes
133AUHNAAUH
Entrez,  Source
AU RNA binding protein/enoyl-Coenzyme A hydratase16610-0.830-0.2508Yes
134DECR1NADECR1
Entrez,  Source
2,4-dienoyl CoA reductase 1, mitochondrial16734-0.867-0.2456Yes
135SDHDNASDHD
Entrez,  Source
succinate dehydrogenase complex, subunit D, integral membrane protein16792-0.886-0.2365Yes
136HPGDNAHPGD
Entrez,  Source
hydroxyprostaglandin dehydrogenase 15-(NAD)17020-0.982-0.2354Yes
137IDI1NAIDI1
Entrez,  Source
isopentenyl-diphosphate delta isomerase 117064-0.996-0.2240Yes
138CD36NACD36
Entrez,  Source
CD36 molecule (thrombospondin receptor)17086-1.007-0.2112Yes
139ECH1NAECH1
Entrez,  Source
enoyl Coenzyme A hydratase 1, peroxisomal17135-1.027-0.1996Yes
140FMO1NAFMO1
Entrez,  Source
flavin containing monooxygenase 117142-1.029-0.1856Yes
141ACADMNAACADM
Entrez,  Source
acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain17198-1.057-0.1740Yes
142ETFDHNAETFDH
Entrez,  Source
electron-transferring-flavoprotein dehydrogenase17242-1.085-0.1613Yes
143MDH1NAMDH1
Entrez,  Source
malate dehydrogenase 1, NAD (soluble)17345-1.146-0.1510Yes
144FABP2NAFABP2
Entrez,  Source
fatty acid binding protein 2, intestinal17450-1.217-0.1399Yes
145GPD1NAGPD1
Entrez,  Source
glycerol-3-phosphate dehydrogenase 1 (soluble)17485-1.245-0.1245Yes
146BCKDHBNABCKDHB
Entrez,  Source
branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease)17499-1.258-0.1077Yes
147ACSM3NAACSM3
Entrez,  Source
acyl-CoA synthetase medium-chain family member 317767-1.561-0.1009Yes
148ACSL1NAACSL1
Entrez,  Source
acyl-CoA synthetase long-chain family member 117864-1.764-0.0817Yes
149AOC3NAAOC3
Entrez,  Source
amine oxidase, copper containing 3 (vascular adhesion protein 1)17906-1.868-0.0581Yes
150TP53INP2NATP53INP2
Entrez,  Source
tumor protein p53 inducible nuclear protein 217996-2.246-0.0318Yes
151ENO3NAENO3
Entrez,  Source
enolase 3 (beta, muscle)18098-2.9690.0038Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_FATTY_ACID_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_FATTY_ACID_METABOLISM: Random ES distribution   
Gene set null distribution of ES for HALLMARK_FATTY_ACID_METABOLISM