Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_ESTROGEN_RESPONSE_EARLY
Enrichment Score (ES)0.2929033
Normalized Enrichment Score (NES)1.1660323
Nominal p-value0.1597015
FDR q-value0.27083302
FWER p-Value0.997
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_ESTROGEN_RESPONSE_EARLY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1AREGNAAREG
Entrez,  Source
amphiregulin (schwannoma-derived growth factor)973.2410.0157Yes
2PMAIP1NAPMAIP1
Entrez,  Source
phorbol-12-myristate-13-acetate-induced protein 11103.1030.0351Yes
3IGFBP4NAIGFBP4
Entrez,  Source
insulin-like growth factor binding protein 41362.8250.0521Yes
4KLF4NAKLF4
Entrez,  Source
Kruppel-like factor 4 (gut)1722.5500.0667Yes
5TGM2NATGM2
Entrez,  Source
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)2132.3440.0797Yes
6PODXLNAPODXL
Entrez,  Source
podocalyxin-like3051.9580.0874Yes
7JAK2NAJAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)3061.9580.1001Yes
8TSKUNA3221.9040.1116Yes
9KRT18NAKRT18
Entrez,  Source
keratin 183721.7710.1204Yes
10MAST4NAMAST4
Entrez,  Source
microtubule associated serine/threonine kinase family member 43901.7350.1307Yes
11CYP26B1NACYP26B1
Entrez,  Source
cytochrome P450, family 26, subfamily B, polypeptide 13951.7260.1417Yes
12KAZNNA3991.7190.1527Yes
13KRT8NAKRT8
Entrez,  Source
keratin 84121.6890.1630Yes
14TPBGNATPBG
Entrez,  Source
trophoblast glycoprotein4351.6430.1724Yes
15LRIG1NALRIG1
Entrez,  Source
leucine-rich repeats and immunoglobulin-like domains 14581.5960.1816Yes
16SFNNASFN
Entrez,  Source
stratifin5131.5240.1885Yes
17CD44NACD44
Entrez,  Source
CD44 molecule (Indian blood group)5151.5230.1983Yes
18PRSS23NAPRSS23
Entrez,  Source
protease, serine, 235241.5160.2077Yes
19ELF1NAELF1
Entrez,  Source
E74-like factor 1 (ets domain transcription factor)6141.4050.2119Yes
20SLC37A1NASLC37A1
Entrez,  Source
solute carrier family 37 (glycerol-3-phosphate transporter), member 16311.3870.2200Yes
21TFF1NATFF1
Entrez,  Source
trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in)6461.3720.2281Yes
22KCNK5NAKCNK5
Entrez,  Source
potassium channel, subfamily K, member 56731.3460.2354Yes
23FAM102ANAFAM102A
Entrez,  Source
family with sequence similarity 102, member A7211.3080.2413Yes
24MICBNAMICB
Entrez,  Source
MHC class I polypeptide-related sequence B7981.2460.2452Yes
25IL6STNAIL6ST
Entrez,  Source
interleukin 6 signal transducer (gp130, oncostatin M receptor)10011.1180.2412Yes
26ABHD2NAABHD2
Entrez,  Source
abhydrolase domain containing 210051.1170.2483Yes
27HES1NAHES1
Entrez,  Source
hairy and enhancer of split 1, (Drosophila)10721.0820.2516Yes
28KRT19NAKRT19
Entrez,  Source
keratin 1912091.0150.2507Yes
29FLNBNAFLNB
Entrez,  Source
filamin B, beta (actin binding protein 278)12201.0110.2567Yes
30MSMBNAMSMB
Entrez,  Source
microseminoprotein, beta-12411.0020.2621Yes
31WWC1NAWWC1
Entrez,  Source
WW, C2 and coiled-coil domain containing 112920.9840.2657Yes
32WFS1NAWFS1
Entrez,  Source
Wolfram syndrome 1 (wolframin)13930.9480.2663Yes
33SVILNASVIL
Entrez,  Source
supervillin14240.9400.2707Yes
34GAB2NAGAB2
Entrez,  Source
GRB2-associated binding protein 214370.9350.2761Yes
35MREGNA14380.9340.2822Yes
36RRP12NA14550.9260.2873Yes
37SLC1A1NASLC1A1
Entrez,  Source
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 114630.9230.2929Yes
38PTGESNAPTGES
Entrez,  Source
prostaglandin E synthase18050.8290.2793No
39PPIFNAPPIF
Entrez,  Source
peptidylprolyl isomerase F (cyclophilin F)18360.8210.2830No
40MYBBP1ANAMYBBP1A
Entrez,  Source
MYB binding protein (P160) 1a19710.7930.2807No
41TMEM164NATMEM164
Entrez,  Source
transmembrane protein 16421150.7630.2777No
42RARANARARA
Entrez,  Source
retinoic acid receptor, alpha22900.7260.2727No
43KLF10NAKLF10
Entrez,  Source
Kruppel-like factor 1023500.7110.2740No
44UGCGNAUGCG
Entrez,  Source
UDP-glucose ceramide glucosyltransferase24340.6970.2740No
45MYBL1NAMYBL1
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)-like 126210.6630.2679No
46MPPED2NAMPPED2
Entrez,  Source
metallophosphoesterase domain containing 228320.6260.2603No
47XBP1NAXBP1
Entrez,  Source
X-box binding protein 128460.6240.2636No
48ARNAAR
Entrez,  Source
androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)28500.6230.2675No
49SLC1A4NASLC1A4
Entrez,  Source
solute carrier family 1 (glutamate/neutral amino acid transporter), member 429120.6120.2681No
50BHLHE40NA29730.6010.2686No
51NXT1NANXT1
Entrez,  Source
NTF2-like export factor 130280.5920.2695No
52THSD4NATHSD4
Entrez,  Source
thrombospondin, type I, domain containing 431260.5780.2678No
53GFRA1NAGFRA1
Entrez,  Source
GDNF family receptor alpha 134250.5330.2547No
54KCNK15NAKCNK15
Entrez,  Source
potassium channel, subfamily K, member 1534510.5290.2568No
55SLC27A2NASLC27A2
Entrez,  Source
solute carrier family 27 (fatty acid transporter), member 234930.5230.2579No
56CISHNACISH
Entrez,  Source
cytokine inducible SH2-containing protein36020.5100.2552No
57TPD52L1NATPD52L1
Entrez,  Source
tumor protein D52-like 136620.5020.2552No
58LAD1NALAD1
Entrez,  Source
ladinin 137910.4860.2512No
59INHBBNAINHBB
Entrez,  Source
inhibin, beta B (activin AB beta polypeptide)38380.4820.2518No
60TUBB2BNATUBB2B
Entrez,  Source
tubulin, beta 2B40030.4610.2456No
61PLA2G16NA40500.4550.2460No
62MAPTNAMAPT
Entrez,  Source
microtubule-associated protein tau41680.4390.2424No
63MYOFNA42090.4330.2430No
64FKBP4NAFKBP4
Entrez,  Source
FK506 binding protein 4, 59kDa42850.4240.2415No
65CANT1NACANT1
Entrez,  Source
calcium activated nucleotidase 144200.4090.2367No
66CCND1NACCND1
Entrez,  Source
cyclin D144400.4070.2383No
67ELOVL2NAELOVL2
Entrez,  Source
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 244440.4060.2408No
68MED24NA46340.3890.2328No
69MUC1NAMUC1
Entrez,  Source
mucin 1, cell surface associated46880.3840.2324No
70DHRS2NADHRS2
Entrez,  Source
dehydrogenase/reductase (SDR family) member 248190.3710.2275No
71BCL11BNABCL11B
Entrez,  Source
B-cell CLL/lymphoma 11B (zinc finger protein)48320.3700.2293No
72UNC119NAUNC119
Entrez,  Source
unc-119 homolog (C. elegans)48350.3700.2315No
73AKAP1NAAKAP1
Entrez,  Source
A kinase (PRKA) anchor protein 148390.3690.2338No
74SCNN1ANASCNN1A
Entrez,  Source
sodium channel, nonvoltage-gated 1 alpha53450.3180.2077No
75SLC2A1NASLC2A1
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 154580.3070.2035No
76TIPARPNATIPARP
Entrez,  Source
TCDD-inducible poly(ADP-ribose) polymerase54780.3050.2044No
77RBBP8NARBBP8
Entrez,  Source
retinoblastoma binding protein 856370.2930.1975No
78SLC22A5NASLC22A5
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 558310.2750.1886No
79SLC16A1NASLC16A1
Entrez,  Source
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)59390.2670.1844No
80HSPB8NAHSPB8
Entrez,  Source
heat shock 22kDa protein 859680.2650.1845No
81ENDOD1NAENDOD1
Entrez,  Source
endonuclease domain containing 159870.2650.1853No
82TOB1NATOB1
Entrez,  Source
transducer of ERBB2, 166030.2120.1524No
83BLVRBNABLVRB
Entrez,  Source
biliverdin reductase B (flavin reductase (NADPH))68450.1920.1402No
84SIAH2NASIAH2
Entrez,  Source
seven in absentia homolog 2 (Drosophila)69520.1830.1355No
85CA12NACA12
Entrez,  Source
carbonic anhydrase XII71250.1710.1271No
86P2RY2NAP2RY2
Entrez,  Source
purinergic receptor P2Y, G-protein coupled, 272650.1620.1204No
87OLFML3NAOLFML3
Entrez,  Source
olfactomedin-like 373850.1530.1148No
88AMFRNAAMFR
Entrez,  Source
autocrine motility factor receptor74160.1500.1141No
89ITPK1NAITPK1
Entrez,  Source
inositol 1,3,4-triphosphate 5/6 kinase75750.1380.1062No
90MED13LNA76720.1320.1017No
91TIAM1NATIAM1
Entrez,  Source
T-cell lymphoma invasion and metastasis 179820.1090.0852No
92GLANAGLA
Entrez,  Source
galactosidase, alpha80090.1060.0845No
93SYNGR1NASYNGR1
Entrez,  Source
synaptogyrin 183180.0840.0679No
94ESRP2NA86030.0650.0525No
95NADSYN1NANADSYN1
Entrez,  Source
NAD synthetase 186590.0600.0498No
96NRIP1NANRIP1
Entrez,  Source
nuclear receptor interacting protein 187880.0520.0430No
97NCOR2NANCOR2
Entrez,  Source
nuclear receptor co-repressor 288160.0500.0419No
98PEX11ANAPEX11A
Entrez,  Source
peroxisomal biogenesis factor 11A90430.0320.0295No
99FOXC1NAFOXC1
Entrez,  Source
forkhead box C192350.0190.0190No
100TFF3NATFF3
Entrez,  Source
trefoil factor 3 (intestinal)96090.000-0.0018No
101KLK10NAKLK10
Entrez,  Source
kallikrein 109748-0.002-0.0094No
102SNX24NASNX24
Entrez,  Source
sorting nexing 249905-0.012-0.0180No
103KRT15NAKRT15
Entrez,  Source
keratin 159953-0.017-0.0205No
104HRNAHR
Entrez,  Source
hairless homolog (mouse)10084-0.024-0.0276No
105IGF1RNAIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor10119-0.027-0.0293No
106FKBP5NAFKBP5
Entrez,  Source
FK506 binding protein 510207-0.031-0.0340No
107PDLIM3NAPDLIM3
Entrez,  Source
PDZ and LIM domain 310224-0.033-0.0346No
108PGRNAPGR
Entrez,  Source
progesterone receptor10296-0.038-0.0384No
109SOX3NASOX3
Entrez,  Source
SRY (sex determining region Y)-box 310337-0.040-0.0403No
110NAV2NANAV2
Entrez,  Source
neuron navigator 210590-0.053-0.0540No
111RETNARET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)10661-0.059-0.0575No
112RAPGEFL1NARAPGEFL1
Entrez,  Source
Rap guanine nucleotide exchange factor (GEF)-like 111176-0.090-0.0855No
113SYT12NASYT12
Entrez,  Source
synaptotagmin XII11263-0.096-0.0897No
114SLC9A3R1NASLC9A3R1
Entrez,  Source
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 111436-0.109-0.0985No
115AQP3NAAQP3
Entrez,  Source
aquaporin 3 (Gill blood group)11508-0.116-0.1017No
116B4GALT1NAB4GALT1
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 111658-0.128-0.1092No
117TGIF2NATGIF2
Entrez,  Source
TGFB-induced factor 2 (TALE family homeobox)11713-0.133-0.1114No
118FASNNAFASN
Entrez,  Source
fatty acid synthase11717-0.133-0.1107No
119KDM4BNA11904-0.148-0.1200No
120SYBUNA12083-0.162-0.1289No
121PAPSS2NAPAPSS2
Entrez,  Source
3'-phosphoadenosine 5'-phosphosulfate synthase 212427-0.195-0.1467No
122DHCR7NADHCR7
Entrez,  Source
7-dehydrocholesterol reductase12472-0.198-0.1479No
123OVOL2NAOVOL2
Entrez,  Source
ovo-like 2 (Drosophila)12586-0.209-0.1528No
124FHL2NAFHL2
Entrez,  Source
four and a half LIM domains 212840-0.229-0.1654No
125TBC1D30NA12938-0.239-0.1692No
126STC2NASTC2
Entrez,  Source
stanniocalcin 212988-0.244-0.1704No
127ELOVL5NAELOVL5
Entrez,  Source
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)13047-0.249-0.1720No
128ADCY9NAADCY9
Entrez,  Source
adenylate cyclase 913293-0.271-0.1839No
129ZNF185NAZNF185
Entrez,  Source
zinc finger protein 185 (LIM domain)13428-0.285-0.1895No
130NPY1RNANPY1R
Entrez,  Source
neuropeptide Y receptor Y113611-0.302-0.1976No
131CALB2NACALB2
Entrez,  Source
calbindin 2, 29kDa (calretinin)13671-0.309-0.1989No
132GJA1NAGJA1
Entrez,  Source
gap junction protein, alpha 1, 43kDa (connexin 43)13672-0.309-0.1969No
133MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)13741-0.315-0.1986No
134MLPHNAMLPH
Entrez,  Source
melanophilin13876-0.328-0.2040No
135TFAP2CNATFAP2C
Entrez,  Source
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)13914-0.332-0.2039No
136ASB13NAASB13
Entrez,  Source
ankyrin repeat and SOCS box-containing 1314055-0.352-0.2094No
137ABLIM1NAABLIM1
Entrez,  Source
actin binding LIM protein 114302-0.380-0.2206No
138RASGRP1NARASGRP1
Entrez,  Source
RAS guanyl releasing protein 1 (calcium and DAG-regulated)14367-0.387-0.2216No
139BCL2NABCL2
Entrez,  Source
B-cell CLL/lymphoma 214397-0.390-0.2207No
140FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog14425-0.395-0.2197No
141SLC26A2NASLC26A2
Entrez,  Source
solute carrier family 26 (sulfate transporter), member 214688-0.429-0.2315No
142INPP5FNAINPP5F
Entrez,  Source
inositol polyphosphate-5-phosphatase F14738-0.435-0.2314No
143CLIC3NACLIC3
Entrez,  Source
chloride intracellular channel 314984-0.472-0.2419No
144CXCL12NACXCL12
Entrez,  Source
chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)15002-0.475-0.2398No
145SLC19A2NASLC19A2
Entrez,  Source
solute carrier family 19 (thiamine transporter), member 215063-0.484-0.2400No
146ELF3NAELF3
Entrez,  Source
E74-like factor 3 (ets domain transcription factor, epithelial-specific )15128-0.492-0.2403No
147RAB31NARAB31
Entrez,  Source
RAB31, member RAS oncogene family15186-0.500-0.2403No
148FDFT1NAFDFT1
Entrez,  Source
farnesyl-diphosphate farnesyltransferase 115277-0.513-0.2419No
149CELSR1NACELSR1
Entrez,  Source
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)15331-0.521-0.2415No
150IL17RBNAIL17RB
Entrez,  Source
interleukin 17 receptor B15607-0.572-0.2531No
151BAG1NABAG1
Entrez,  Source
BCL2-associated athanogene15643-0.580-0.2513No
152TMPRSS3NATMPRSS3
Entrez,  Source
transmembrane protease, serine 315657-0.582-0.2482No
153SLC7A2NASLC7A2
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 215789-0.609-0.2515No
154GREB1NAGREB1
Entrez,  Source
-15805-0.611-0.2484No
155NBL1NANBL1
Entrez,  Source
neuroblastoma, suppression of tumorigenicity 115822-0.614-0.2453No
156SEMA3BNASEMA3B
Entrez,  Source
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B15844-0.620-0.2425No
157SCARB1NASCARB1
Entrez,  Source
scavenger receptor class B, member 115938-0.640-0.2435No
158CELSR2NACELSR2
Entrez,  Source
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)15994-0.655-0.2423No
159SLC24A3NASLC24A3
Entrez,  Source
solute carrier family 24 (sodium/potassium/calcium exchanger), member 316076-0.674-0.2424No
160RHODNARHOD
Entrez,  Source
ras homolog gene family, member D16131-0.688-0.2409No
161CHPT1NACHPT1
Entrez,  Source
choline phosphotransferase 116251-0.721-0.2429No
162AFF1NAAFF1
Entrez,  Source
AF4/FMR2 family, member 116286-0.729-0.2400No
163ABCA3NAABCA3
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 316288-0.730-0.2354No
164ALDH3B1NAALDH3B1
Entrez,  Source
aldehyde dehydrogenase 3 family, member B116343-0.746-0.2335No
165ADD3NAADD3
Entrez,  Source
adducin 3 (gamma)16366-0.753-0.2299No
166CBFA2T3NACBFA2T3
Entrez,  Source
core-binding factor, runt domain, alpha subunit 2; translocated to, 316370-0.754-0.2251No
167MYBNAMYB
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)16878-0.916-0.2474No
168ARL3NAARL3
Entrez,  Source
ADP-ribosylation factor-like 316915-0.932-0.2433No
169ADCY1NAADCY1
Entrez,  Source
adenylate cyclase 1 (brain)17024-0.984-0.2430No
170OPN3NAOPN3
Entrez,  Source
opsin 3 (encephalopsin, panopsin)17041-0.989-0.2374No
171TTC39ANA17080-1.004-0.2330No
172ANXA9NAANXA9
Entrez,  Source
annexin A917115-1.021-0.2283No
173DYNLT3NADYNLT3
Entrez,  Source
dynein, light chain, Tctex-type 317119-1.024-0.2218No
174EGR3NAEGR3
Entrez,  Source
early growth response 317235-1.079-0.2212No
175RAB17NARAB17
Entrez,  Source
RAB17, member RAS oncogene family17255-1.093-0.2151No
176CALCRNACALCR
Entrez,  Source
calcitonin receptor17373-1.168-0.2141No
177ABATNAABAT
Entrez,  Source
4-aminobutyrate aminotransferase17441-1.211-0.2099No
178SEC14L2NASEC14L2
Entrez,  Source
SEC14-like 2 (S. cerevisiae)17470-1.236-0.2035No
179FRKNAFRK
Entrez,  Source
fyn-related kinase17558-1.303-0.1998No
180SLC7A5NASLC7A5
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 517569-1.313-0.1919No
181DEPTORNA17739-1.514-0.1914No
182SULT2B1NASULT2B1
Entrez,  Source
sulfotransferase family, cytosolic, 2B, member 117782-1.584-0.1835No
183RHOBTB3NARHOBTB3
Entrez,  Source
Rho-related BTB domain containing 317825-1.680-0.1749No
184FARP1NAFARP1
Entrez,  Source
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)17837-1.703-0.1645No
185DLC1NADLC1
Entrez,  Source
deleted in liver cancer 117838-1.704-0.1534No
186PDZK1NAPDZK1
Entrez,  Source
PDZ domain containing 117846-1.728-0.1426No
187SH3BP5NASH3BP5
Entrez,  Source
SH3-domain binding protein 5 (BTK-associated)17850-1.730-0.1315No
188DHRS3NADHRS3
Entrez,  Source
dehydrogenase/reductase (SDR family) member 317931-1.939-0.1234No
189SLC39A6NASLC39A6
Entrez,  Source
solute carrier family 39 (zinc transporter), member 617949-2.024-0.1112No
190CLDN7NACLDN7
Entrez,  Source
claudin 717954-2.035-0.0982No
191RPS6KA2NARPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 218001-2.261-0.0860No
192WISP2NAWISP2
Entrez,  Source
WNT1 inducible signaling pathway protein 218101-3.015-0.0720No
193REEP1NAREEP1
Entrez,  Source
receptor accessory protein 118109-3.167-0.0518No
194KRT13NAKRT13
Entrez,  Source
keratin 1318137-3.630-0.0297No
195OLFM1NAOLFM1
Entrez,  Source
olfactomedin 118165-4.8240.0001No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_ESTROGEN_RESPONSE_EARLY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_ESTROGEN_RESPONSE_EARLY: Random ES distribution   
Gene set null distribution of ES for HALLMARK_ESTROGEN_RESPONSE_EARLY