Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_E2F_TARGETS
Enrichment Score (ES)-0.21185008
Normalized Enrichment Score (NES)-0.8960635
Nominal p-value0.81088823
FDR q-value0.7747161
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_E2F_TARGETS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CHEK2NACHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)2822.0530.0112No
2TUBBNATUBB
Entrez,  Source
tubulin, beta10751.081-0.0188No
3RRM2NARRM2
Entrez,  Source
ribonucleotide reductase M2 polypeptide12051.016-0.0127No
4DCLRE1BNADCLRE1B
Entrez,  Source
DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)14170.942-0.0121No
5E2F8NAE2F8
Entrez,  Source
E2F transcription factor 816730.859-0.0150No
6HMGA1NAHMGA1
Entrez,  Source
high mobility group AT-hook 116990.850-0.0053No
7POLD1NAPOLD1
Entrez,  Source
polymerase (DNA directed), delta 1, catalytic subunit 125kDa17630.8360.0021No
8POP7NAPOP7
Entrez,  Source
processing of precursor 7, ribonuclease P subunit (S. cerevisiae)20620.775-0.0043No
9NUP153NANUP153
Entrez,  Source
nucleoporin 153kDa22460.735-0.0049No
10POLD3NAPOLD3
Entrez,  Source
polymerase (DNA-directed), delta 3, accessory subunit22640.7320.0037No
11TUBG1NATUBG1
Entrez,  Source
tubulin, gamma 123550.7110.0080No
12ORC6NA23690.7080.0165No
13BRMS1LNABRMS1L
Entrez,  Source
breast cancer metastasis-suppressor 1-like24900.6860.0188No
14MELKNAMELK
Entrez,  Source
maternal embryonic leucine zipper kinase25560.6750.0240No
15ING3NAING3
Entrez,  Source
inhibitor of growth family, member 327080.6480.0241No
16PSMC3IPNAPSMC3IP
Entrez,  Source
PSMC3 interacting protein28370.6260.0252No
17H2AFXNAH2AFX
Entrez,  Source
H2A histone family, member X28490.6230.0327No
18BRCA2NABRCA2
Entrez,  Source
breast cancer 2, early onset28550.6220.0406No
19USP1NAUSP1
Entrez,  Source
ubiquitin specific peptidase 129010.6130.0461No
20SUV39H1NASUV39H1
Entrez,  Source
suppressor of variegation 3-9 homolog 1 (Drosophila)31430.5760.0402No
21XPO1NAXPO1
Entrez,  Source
exportin 1 (CRM1 homolog, yeast)31690.5710.0463No
22WEE1NAWEE1
Entrez,  Source
WEE1 homolog (S. pombe)32410.5610.0497No
23DNMT1NADNMT1
Entrez,  Source
DNA (cytosine-5-)-methyltransferase 132720.5560.0553No
24LYARNALYAR
Entrez,  Source
-32800.5550.0622No
25GSPT1NAGSPT1
Entrez,  Source
G1 to S phase transition 135300.5190.0551No
26RAD51CNARAD51C
Entrez,  Source
RAD51 homolog C (S. cerevisiae)36630.5020.0543No
27CDC25ANACDC25A
Entrez,  Source
cell division cycle 25A36710.5010.0605No
28IPO7NAIPO7
Entrez,  Source
importin 737300.4940.0637No
29MSH2NAMSH2
Entrez,  Source
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)39450.4680.0579No
30TIPINNATIPIN
Entrez,  Source
TIMELESS interacting protein39560.4670.0634No
31NOP56NA40240.4590.0657No
32AURKBNAAURKB
Entrez,  Source
aurora kinase B41030.4470.0672No
33NASPNANASP
Entrez,  Source
nuclear autoantigenic sperm protein (histone-binding)44500.4050.0533No
34NOLC1NANOLC1
Entrez,  Source
nucleolar and coiled-body phosphoprotein 144880.4020.0565No
35CTCFNACTCF
Entrez,  Source
CCCTC-binding factor (zinc finger protein)45320.3990.0593No
36EZH2NAEZH2
Entrez,  Source
enhancer of zeste homolog 2 (Drosophila)45370.3990.0643No
37RFC2NARFC2
Entrez,  Source
replication factor C (activator 1) 2, 40kDa45560.3970.0685No
38GINS3NAGINS3
Entrez,  Source
GINS complex subunit 3 (Psf3 homolog)46400.3880.0689No
39NBNNANBN
Entrez,  Source
nibrin47200.3800.0695No
40TBRG4NATBRG4
Entrez,  Source
transforming growth factor beta regulator 448660.3650.0662No
41DDX39ANA49590.3550.0657No
42SMC6NASMC6
Entrez,  Source
structural maintenance of chromosomes 649670.3540.0700No
43CCP110NA50000.3520.0728No
44MCM7NAMCM7
Entrez,  Source
MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)50570.3450.0742No
45PHF5ANAPHF5A
Entrez,  Source
PHD finger protein 5A50840.3430.0772No
46BARD1NABARD1
Entrez,  Source
BRCA1 associated RING domain 150920.3420.0813No
47MMS22LNA51190.3400.0843No
48EIF2S1NAEIF2S1
Entrez,  Source
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa51550.3360.0868No
49DONSONNADONSON
Entrez,  Source
downstream neighbor of SON52100.3300.0881No
50ZW10NAZW10
Entrez,  Source
ZW10, kinetochore associated, homolog (Drosophila)52110.3300.0924No
51HUS1NAHUS1
Entrez,  Source
HUS1 checkpoint homolog (S. pombe)54730.3050.0819No
52GINS1NAGINS1
Entrez,  Source
GINS complex subunit 1 (Psf1 homolog)54910.3040.0849No
53PA2G4NAPA2G4
Entrez,  Source
proliferation-associated 2G4, 38kDa55730.2980.0843No
54UBR7NA56040.2950.0865No
55CDK4NACDK4
Entrez,  Source
cyclin-dependent kinase 456790.2880.0861No
56SMC1ANASMC1A
Entrez,  Source
structural maintenance of chromosomes 1A60200.2620.0707No
57RAD1NARAD1
Entrez,  Source
RAD1 homolog (S. pombe)60700.2570.0713No
58POLA2NAPOLA2
Entrez,  Source
polymerase (DNA directed), alpha 2 (70kD subunit)60900.2550.0736No
59SYNCRIPNASYNCRIP
Entrez,  Source
synaptotagmin binding, cytoplasmic RNA interacting protein63140.2360.0642No
60RANBP1NARANBP1
Entrez,  Source
RAN binding protein 163730.2310.0640No
61ESPL1NAESPL1
Entrez,  Source
extra spindle poles like 1 (S. cerevisiae)64390.2260.0634No
62BRCA1NABRCA1
Entrez,  Source
breast cancer 1, early onset64750.2230.0643No
63CDC20NACDC20
Entrez,  Source
CDC20 cell division cycle 20 homolog (S. cerevisiae)65010.2210.0658No
64MCM5NAMCM5
Entrez,  Source
MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)65270.2180.0673No
65STAG1NASTAG1
Entrez,  Source
stromal antigen 166200.2100.0649No
66RPA2NARPA2
Entrez,  Source
replication protein A2, 32kDa67140.2020.0624No
67LMNB1NALMNB1
Entrez,  Source
lamin B167640.1980.0623No
68CCNE1NACCNE1
Entrez,  Source
cyclin E167720.1980.0645No
69CDKN2CNACDKN2C
Entrez,  Source
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)67940.1970.0659No
70DCTPP1NA68510.1910.0652No
71CDC25BNACDC25B
Entrez,  Source
cell division cycle 25B69150.1860.0642No
72MCM2NAMCM2
Entrez,  Source
MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)69260.1850.0660No
73ASF1BNAASF1B
Entrez,  Source
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)72780.1610.0486No
74RNASEH2ANARNASEH2A
Entrez,  Source
ribonuclease H2, subunit A73110.1590.0489No
75MYBL2NAMYBL2
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)-like 273290.1570.0500No
76CSE1LNACSE1L
Entrez,  Source
CSE1 chromosome segregation 1-like (yeast)73350.1570.0518No
77TCF19NATCF19
Entrez,  Source
transcription factor 19 (SC1)74370.1480.0481No
78CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)75230.1430.0452No
79CENPMNACENPM
Entrez,  Source
centromere protein M76950.1300.0374No
80TMPONATMPO
Entrez,  Source
thymopoietin77420.1270.0365No
81POLENAPOLE
Entrez,  Source
polymerase (DNA directed), epsilon78350.1200.0330No
82EXOSC8NAEXOSC8
Entrez,  Source
exosome component 879070.1140.0305No
83DCKNADCK
Entrez,  Source
deoxycytidine kinase79350.1130.0305No
84MLH1NAMLH1
Entrez,  Source
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)79410.1120.0317No
85CDCA8NACDCA8
Entrez,  Source
cell division cycle associated 880610.1030.0264No
86SLBPNASLBP
Entrez,  Source
stem-loop (histone) binding protein81220.0980.0243No
87TRA2BNA81300.0970.0252No
88AK2NAAK2
Entrez,  Source
adenylate kinase 281900.0940.0232No
89PPM1DNAPPM1D
Entrez,  Source
protein phosphatase 1D magnesium-dependent, delta isoform83070.0850.0178No
90PDS5BNA84240.0770.0124No
91PCNANAPCNA
Entrez,  Source
proliferating cell nuclear antigen84420.0760.0124No
92NUP205NANUP205
Entrez,  Source
nucleoporin 205kDa85400.0690.0079No
93DEKNADEK
Entrez,  Source
DEK oncogene (DNA binding)85590.0680.0078No
94PPP1R8NAPPP1R8
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 885880.0660.0071No
95MCM4NAMCM4
Entrez,  Source
MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)87040.0570.0015No
96HNRNPDNA87730.052-0.0016No
97PLK4NAPLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)89140.043-0.0089No
98GINS4NAGINS4
Entrez,  Source
GINS complex subunit 4 (Sld5 homolog)89440.040-0.0100No
99NUP107NANUP107
Entrez,  Source
nucleoporin 107kDa91190.026-0.0193No
100CHEK1NACHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)94500.004-0.0376No
101SSRP1NASSRP1
Entrez,  Source
structure specific recognition protein 194550.004-0.0378No
102LIG1NALIG1
Entrez,  Source
ligase I, DNA, ATP-dependent94560.004-0.0377No
103CKS1BNACKS1B
Entrez,  Source
CDC28 protein kinase regulatory subunit 1B9735-0.001-0.0532No
104PRIM2NA9771-0.004-0.0551No
105CDKN2ANACDKN2A
Entrez,  Source
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)9855-0.010-0.0596No
106TRIP13NATRIP13
Entrez,  Source
thyroid hormone receptor interactor 139948-0.016-0.0645No
107UBE2SNAUBE2S
Entrez,  Source
ubiquitin-conjugating enzyme E2S9949-0.016-0.0643No
108SNRPBNASNRPB
Entrez,  Source
small nuclear ribonucleoprotein polypeptides B and B110059-0.023-0.0700No
109KPNA2NAKPNA2
Entrez,  Source
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)10129-0.028-0.0735No
110MTHFD2NAMTHFD2
Entrez,  Source
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase10233-0.033-0.0788No
111UBE2TNAUBE2T
Entrez,  Source
ubiquitin-conjugating enzyme E2T (putative)10250-0.034-0.0792No
112WDR90NAWDR90
Entrez,  Source
WD repeat domain 9010311-0.039-0.0821No
113HELLSNAHELLS
Entrez,  Source
helicase, lymphoid-specific10690-0.060-0.1023No
114PRPS1NAPRPS1
Entrez,  Source
phosphoribosyl pyrophosphate synthetase 110752-0.063-0.1049No
115SMC3NASMC3
Entrez,  Source
structural maintenance of chromosomes 310806-0.065-0.1070No
116ILF3NAILF3
Entrez,  Source
interleukin enhancer binding factor 3, 90kDa10811-0.066-0.1063No
117POLE4NAPOLE4
Entrez,  Source
polymerase (DNA-directed), epsilon 4 (p12 subunit)11174-0.090-0.1253No
118ORC2NA11197-0.091-0.1253No
119RANNARAN
Entrez,  Source
RAN, member RAS oncogene family11382-0.104-0.1342No
120PRDX4NAPRDX4
Entrez,  Source
peroxiredoxin 411418-0.107-0.1348No
121SRSF1NA11517-0.116-0.1387No
122LBRNALBR
Entrez,  Source
lamin B receptor11610-0.123-0.1422No
123ATAD2NAATAD2
Entrez,  Source
ATPase family, AAA domain containing 211655-0.128-0.1430No
124TIMELESSNATIMELESS
Entrez,  Source
timeless homolog (Drosophila)11656-0.128-0.1413No
125MCM3NAMCM3
Entrez,  Source
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)11663-0.128-0.1400No
126MCM6NAMCM6
Entrez,  Source
MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)11820-0.142-0.1468No
127TACC3NATACC3
Entrez,  Source
transforming, acidic coiled-coil containing protein 312097-0.163-0.1600No
128DUTNADUT
Entrez,  Source
dUTP pyrophosphatase12168-0.170-0.1617No
129KIF22NAKIF22
Entrez,  Source
kinesin family member 2212173-0.171-0.1597No
130RAD50NARAD50
Entrez,  Source
RAD50 homolog (S. cerevisiae)12231-0.176-0.1606No
131CDCA3NACDCA3
Entrez,  Source
cell division cycle associated 312258-0.178-0.1597No
132POLD2NAPOLD2
Entrez,  Source
polymerase (DNA directed), delta 2, regulatory subunit 50kDa12324-0.185-0.1609No
133ASF1ANAASF1A
Entrez,  Source
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)12350-0.187-0.1598No
134PLK1NAPLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)12400-0.191-0.1600No
135NAP1L1NANAP1L1
Entrez,  Source
nucleosome assembly protein 1-like 112483-0.199-0.1620No
136ANP32ENAANP32E
Entrez,  Source
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E12539-0.205-0.1624No
137PRKDCNAPRKDC
Entrez,  Source
protein kinase, DNA-activated, catalytic polypeptide12620-0.212-0.1641No
138DIAPH3NADIAPH3
Entrez,  Source
diaphanous homolog 3 (Drosophila)13005-0.246-0.1822No
139TK1NATK1
Entrez,  Source
thymidine kinase 1, soluble13165-0.259-0.1877No
140NUDT21NANUDT21
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 2113475-0.290-0.2011No
141SPC25NA13476-0.290-0.1973No
142NAA38NA13555-0.296-0.1978No
143RAD51AP1NARAD51AP1
Entrez,  Source
RAD51 associated protein 113566-0.297-0.1944No
144DSCC1NA13653-0.307-0.1952No
145MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)13741-0.315-0.1959No
146KIF4ANAKIF4A
Entrez,  Source
kinesin family member 4A14011-0.346-0.2063No
147PAICSNAPAICS
Entrez,  Source
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase14063-0.353-0.2046No
148PMS2NAPMS2
Entrez,  Source
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)14066-0.353-0.2001No
149MKI67NAMKI67
Entrez,  Source
antigen identified by monoclonal antibody Ki-6714279-0.377-0.2069Yes
150RFC3NARFC3
Entrez,  Source
replication factor C (activator 1) 3, 38kDa14323-0.382-0.2043Yes
151CDK1NA14384-0.389-0.2026Yes
152PSIP1NAPSIP1
Entrez,  Source
PC4 and SFRS1 interacting protein 114407-0.391-0.1987Yes
153CITNACIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)14440-0.397-0.1953Yes
154KIF2CNAKIF2C
Entrez,  Source
kinesin family member 2C14496-0.404-0.1930Yes
155XRCC6NAXRCC6
Entrez,  Source
X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa)14534-0.410-0.1897Yes
156RFC1NARFC1
Entrez,  Source
replication factor C (activator 1) 1, 145kDa14576-0.416-0.1866Yes
157NME1NANME1
Entrez,  Source
non-metastatic cells 1, protein (NM23A) expressed in14686-0.429-0.1870Yes
158SRSF2NA14780-0.442-0.1864Yes
159MAD2L1NAMAD2L1
Entrez,  Source
MAD2 mitotic arrest deficient-like 1 (yeast)14791-0.444-0.1812Yes
160PNNNAPNN
Entrez,  Source
pinin, desmosome associated protein15079-0.486-0.1908Yes
161BIRC5NABIRC5
Entrez,  Source
baculoviral IAP repeat-containing 5 (survivin)15435-0.539-0.2035Yes
162RBBP7NARBBP7
Entrez,  Source
retinoblastoma binding protein 715459-0.543-0.1977Yes
163SMC4NASMC4
Entrez,  Source
structural maintenance of chromosomes 415518-0.555-0.1936Yes
164SPC24NA15600-0.570-0.1907Yes
165H2AFZNAH2AFZ
Entrez,  Source
H2A histone family, member Z15685-0.587-0.1877Yes
166LUC7L3NA15817-0.613-0.1870Yes
167RAD21NARAD21
Entrez,  Source
RAD21 homolog (S. pombe)15874-0.627-0.1819Yes
168BUB1BNABUB1B
Entrez,  Source
BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)15921-0.635-0.1761Yes
169TP53NATP53
Entrez,  Source
tumor protein p53 (Li-Fraumeni syndrome)15988-0.654-0.1713Yes
170RACGAP1NARACGAP1
Entrez,  Source
Rac GTPase activating protein 116022-0.661-0.1645Yes
171CKS2NACKS2
Entrez,  Source
CDC28 protein kinase regulatory subunit 216029-0.662-0.1561Yes
172RPA1NARPA1
Entrez,  Source
replication protein A1, 70kDa16047-0.668-0.1484Yes
173AURKANAAURKA
Entrez,  Source
aurora kinase A16121-0.685-0.1434Yes
174MXD3NAMXD3
Entrez,  Source
MAX dimerization protein 316189-0.703-0.1380Yes
175TOP2ANATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa16265-0.724-0.1327Yes
176HMGB3NAHMGB3
Entrez,  Source
high-mobility group box 316337-0.743-0.1269Yes
177RPA3NARPA3
Entrez,  Source
replication protein A3, 14kDa16348-0.748-0.1177Yes
178STMN1NASTMN1
Entrez,  Source
stathmin 1/oncoprotein 1816362-0.751-0.1086Yes
179DEPDC1NADEPDC1
Entrez,  Source
DEP domain containing 116402-0.765-0.1008Yes
180HMMRNAHMMR
Entrez,  Source
hyaluronan-mediated motility receptor (RHAMM)16504-0.799-0.0959Yes
181NCAPD2NANCAPD2
Entrez,  Source
non-SMC condensin I complex, subunit D216688-0.850-0.0950Yes
182UNGNAUNG
Entrez,  Source
uracil-DNA glycosylase16725-0.865-0.0857Yes
183CENPENACENPE
Entrez,  Source
centromere protein E, 312kDa16807-0.890-0.0785Yes
184PAN2NA16812-0.893-0.0671Yes
185CDKN1BNACDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)16862-0.909-0.0579Yes
186DLGAP5NA16918-0.934-0.0488Yes
187HMGB2NAHMGB2
Entrez,  Source
high-mobility group box 216990-0.964-0.0401Yes
188CCNB2NACCNB2
Entrez,  Source
cyclin B217059-0.994-0.0309Yes
189PTTG1NAPTTG1
Entrez,  Source
pituitary tumor-transforming 117216-1.070-0.0256Yes
190SPAG5NASPAG5
Entrez,  Source
sperm associated antigen 517230-1.076-0.0122Yes
191CBX5NACBX5
Entrez,  Source
chromobox homolog 5 (HP1 alpha homolog, Drosophila)17338-1.142-0.0033Yes
192SHMT1NASHMT1
Entrez,  Source
serine hydroxymethyltransferase 1 (soluble)17408-1.1940.0085Yes
193TFRCNATFRC
Entrez,  Source
transferrin receptor (p90, CD71)17504-1.2610.0197Yes
194CDKN3NACDKN3
Entrez,  Source
cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)17564-1.3090.0335Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_E2F_TARGETS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_E2F_TARGETS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_E2F_TARGETS