Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_COMPLEMENT
Enrichment Score (ES)0.42921004
Normalized Enrichment Score (NES)1.700289
Nominal p-value0.0
FDR q-value0.00445038
FWER p-Value0.03
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_COMPLEMENT   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CCL5NACCL5
Entrez,  Source
chemokine (C-C motif) ligand 564.7680.0337Yes
2IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)174.5960.0660Yes
3CFBNACFB
Entrez,  Source
complement factor B673.6690.0894Yes
4IRF1NAIRF1
Entrez,  Source
interferon regulatory factor 11123.0670.1089Yes
5CTSSNACTSS
Entrez,  Source
cathepsin S1213.0030.1299Yes
6OLR1NAOLR1
Entrez,  Source
oxidised low density lipoprotein (lectin-like) receptor 11302.8730.1499Yes
7PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor1402.7840.1693Yes
8PSMB9NAPSMB9
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)1472.7210.1884Yes
9DUSP5NADUSP5
Entrez,  Source
dual specificity phosphatase 52252.2820.2004Yes
10ERAP2NA2562.1420.2140Yes
11TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 32712.0950.2282Yes
12SERPINE1NASERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 12902.0390.2418Yes
13F3NAF3
Entrez,  Source
coagulation factor III (thromboplastin, tissue factor)3011.9810.2554Yes
14JAK2NAJAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)3061.9580.2691Yes
15PDP1NA3171.9170.2822Yes
16HSPA1ANAHSPA1A
Entrez,  Source
heat shock 70kDa protein 1A3391.8550.2943Yes
17SH2B3NASH2B3
Entrez,  Source
SH2B adaptor protein 33521.8210.3067Yes
18GCANAGCA
Entrez,  Source
grancalcin, EF-hand calcium binding protein4711.5830.3114Yes
19RCE1NARCE1
Entrez,  Source
RCE1 homolog, prenyl protein peptidase (S. cerevisiae)5851.4370.3154Yes
20SIRT6NASIRT6
Entrez,  Source
sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)5971.4200.3249Yes
21CEBPBNACEBPB
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), beta6191.3960.3337Yes
22HSPA5NAHSPA5
Entrez,  Source
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)7771.2630.3340Yes
23COL4A2NACOL4A2
Entrez,  Source
collagen, type IV, alpha 27941.2520.3420Yes
24GNGT2NAGNGT2
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 28001.2460.3507Yes
25FN1NAFN1
Entrez,  Source
fibronectin 18031.2440.3594Yes
26STX4NASTX4
Entrez,  Source
syntaxin 48071.2430.3681Yes
27SERPINC1NASERPINC1
Entrez,  Source
serpin peptidase inhibitor, clade C (antithrombin), member 18461.2110.3747Yes
28CASP1NACASP1
Entrez,  Source
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)8971.1780.3803Yes
29SRCNASRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)9011.1760.3885Yes
30CASP4NACASP4
Entrez,  Source
caspase 4, apoptosis-related cysteine peptidase9461.1470.3943Yes
31PLSCR1NAPLSCR1
Entrez,  Source
phospholipid scramblase 110711.0830.3951Yes
32MAFFNAMAFF
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)12371.0040.3931Yes
33RHOGNARHOG
Entrez,  Source
ras homolog gene family, member G (rho G)12540.9990.3993Yes
34PRDM4NAPRDM4
Entrez,  Source
PR domain containing 412720.9920.4055Yes
35PRSS36NAPRSS36
Entrez,  Source
protease, serine, 3613040.9810.4108Yes
36ITGAMNAITGAM
Entrez,  Source
integrin, alpha M (complement component 3 receptor 3 subunit)13180.9780.4170Yes
37DOCK10NADOCK10
Entrez,  Source
dedicator of cytokinesis 1013360.9680.4230Yes
38CTSONACTSO
Entrez,  Source
cathepsin O14660.9200.4224Yes
39CTSDNACTSD
Entrez,  Source
cathepsin D (lysosomal aspartyl peptidase)15010.9100.4270Yes
40EHD1NAEHD1
Entrez,  Source
EH-domain containing 115760.8890.4292Yes
41FCER1GNAFCER1G
Entrez,  Source
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide17490.8390.4256No
42CSRP1NACSRP1
Entrez,  Source
cysteine and glycine-rich protein 120300.7830.4156No
43CASP7NACASP7
Entrez,  Source
caspase 7, apoptosis-related cysteine peptidase21310.7580.4155No
44BRPF3NABRPF3
Entrez,  Source
bromodomain and PHD finger containing, 321380.7560.4206No
45IRF2NAIRF2
Entrez,  Source
interferon regulatory factor 223860.7050.4119No
46PFN1NAPFN1
Entrez,  Source
profilin 124040.7020.4159No
47RABIFNARABIF
Entrez,  Source
RAB interacting factor27160.6470.4032No
48GNB2NAGNB2
Entrez,  Source
guanine nucleotide binding protein (G protein), beta polypeptide 227510.6390.4059No
49GATA3NAGATA3
Entrez,  Source
GATA binding protein 328440.6240.4053No
50CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase29030.6130.4064No
51CTSHNACTSH
Entrez,  Source
cathepsin H30630.5870.4017No
52CD55NACD55
Entrez,  Source
CD55 molecule, decay accelerating factor for complement (Cromer blood group)32460.5600.3956No
53CASP10NACASP10
Entrez,  Source
caspase 10, apoptosis-related cysteine peptidase33470.5440.3939No
54SPOCK2NASPOCK2
Entrez,  Source
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 234200.5330.3937No
55TIMP1NATIMP1
Entrez,  Source
TIMP metallopeptidase inhibitor 137970.4860.3763No
56ZEB1NA41110.4450.3621No
57PSEN1NAPSEN1
Entrez,  Source
presenilin 1 (Alzheimer disease 3)42030.4340.3601No
58LYNNALYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog42440.4280.3609No
59PLATNAPLAT
Entrez,  Source
plasminogen activator, tissue43780.4140.3565No
60APOBEC3GNAAPOBEC3G
Entrez,  Source
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G44750.4030.3540No
61PPP4CNAPPP4C
Entrez,  Source
protein phosphatase 4 (formerly X), catalytic subunit45400.3980.3533No
62CASP5NACASP5
Entrez,  Source
caspase 5, apoptosis-related cysteine peptidase45520.3970.3555No
63DOCK4NADOCK4
Entrez,  Source
dedicator of cytokinesis 446710.3860.3517No
64ZFPM2NAZFPM2
Entrez,  Source
zinc finger protein, multitype 247310.3790.3512No
65LGMNNALGMN
Entrez,  Source
legumain50430.3470.3363No
66RNF4NARNF4
Entrez,  Source
ring finger protein 450660.3450.3376No
67HNF4ANAHNF4A
Entrez,  Source
hepatocyte nuclear factor 4, alpha50830.3430.3391No
68C2NAC2
Entrez,  Source
complement component 251390.3380.3385No
69LAP3NALAP3
Entrez,  Source
leucine aminopeptidase 351990.3320.3376No
70USP15NAUSP15
Entrez,  Source
ubiquitin specific peptidase 1552400.3280.3377No
71VCPIP1NAVCPIP1
Entrez,  Source
valosin containing protein (p97)/p47 complex interacting protein 153810.3140.3321No
72C4BPBNAC4BPB
Entrez,  Source
complement component 4 binding protein, beta54080.3120.3329No
73GNAI3NAGNAI3
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 354140.3110.3349No
74LTFNALTF
Entrez,  Source
lactotransferrin55320.3010.3305No
75CD40LGNACD40LG
Entrez,  Source
CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)55450.3000.3320No
76ANXA5NAANXA5
Entrez,  Source
annexin A556530.2910.3281No
77PPP2CBNAPPP2CB
Entrez,  Source
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform56620.2900.3297No
78C9NAC9
Entrez,  Source
complement component 956650.2900.3317No
79PREPNAPREP
Entrez,  Source
prolyl endopeptidase56880.2870.3325No
80MMP8NAMMP8
Entrez,  Source
matrix metallopeptidase 8 (neutrophil collagenase)59090.2690.3222No
81GPD2NAGPD2
Entrez,  Source
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)60060.2630.3187No
82GNG2NAGNG2
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma 261490.2500.3126No
83MMP15NAMMP15
Entrez,  Source
matrix metallopeptidase 15 (membrane-inserted)63280.2340.3044No
84LCKNALCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase66350.2080.2888No
85KIF2ANAKIF2A
Entrez,  Source
kinesin heavy chain member 2A69370.1840.2734No
86CDK5R1NACDK5R1
Entrez,  Source
cyclin-dependent kinase 5, regulatory subunit 1 (p35)70140.1790.2705No
87APOC1NAAPOC1
Entrez,  Source
apolipoprotein C-I72520.1630.2585No
88USP16NAUSP16
Entrez,  Source
ubiquitin specific peptidase 1673600.1550.2536No
89AKAP10NAAKAP10
Entrez,  Source
A kinase (PRKA) anchor protein 1074100.1510.2520No
90LGALS3NALGALS3
Entrez,  Source
lectin, galactoside-binding, soluble, 3 (galectin 3)79580.1110.2223No
91HPCAL4NAHPCAL4
Entrez,  Source
hippocalcin like 481280.0970.2136No
92DPP4NADPP4
Entrez,  Source
dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)82030.0930.2102No
93PIK3CANAPIK3CA
Entrez,  Source
phosphoinositide-3-kinase, catalytic, alpha polypeptide87840.0520.1783No
94XPNPEP1NAXPNPEP1
Entrez,  Source
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble88680.0460.1740No
95PRKCDNAPRKCD
Entrez,  Source
protein kinase C, delta89170.0420.1716No
96F5NAF5
Entrez,  Source
coagulation factor V (proaccelerin, labile factor)90770.0290.1630No
97IRF7NAIRF7
Entrez,  Source
interferon regulatory factor 791070.0270.1615No
98TMPRSS6NATMPRSS6
Entrez,  Source
transmembrane protease, serine 691720.0220.1581No
99DYRK2NADYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 293130.0130.1505No
100USP14NAUSP14
Entrez,  Source
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)93310.0120.1496No
101F8NAF8
Entrez,  Source
coagulation factor VIII, procoagulant component (hemophilia A)93570.0110.1483No
102WASNAWAS
Entrez,  Source
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)93810.0090.1471No
103C1QCNAC1QC
Entrez,  Source
complement component 1, q subcomponent, C chain94370.0040.1440No
104CA2NACA2
Entrez,  Source
carbonic anhydrase II95100.0000.1400No
105GZMKNAGZMK
Entrez,  Source
granzyme K (granzyme 3; tryptase II)95420.0000.1383No
106C1QANAC1QA
Entrez,  Source
complement component 1, q subcomponent, A chain95810.0000.1362No
107PCLONAPCLO
Entrez,  Source
piccolo (presynaptic cytomatrix protein)9774-0.0040.1255No
108SERPINB2NASERPINB2
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 29790-0.0050.1247No
109PDGFBNAPDGFB
Entrez,  Source
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)9832-0.0080.1225No
110GNAI2NAGNAI2
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 210093-0.0250.1082No
111MMP14NAMMP14
Entrez,  Source
matrix metallopeptidase 14 (membrane-inserted)10281-0.0370.0981No
112CALM1NACALM1
Entrez,  Source
calmodulin 1 (phosphorylase kinase, delta)10458-0.0450.0886No
113LIPANALIPA
Entrez,  Source
lipase A, lysosomal acid, cholesterol esterase (Wolman disease)10598-0.0540.0813No
114S100A9NAS100A9
Entrez,  Source
S100 calcium binding protein A910672-0.0590.0776No
115CBLBNACBLB
Entrez,  Source
Cas-Br-M (murine) ecotropic retroviral transforming sequence b10677-0.0590.0778No
116FCN1NAFCN1
Entrez,  Source
ficolin (collagen/fibrinogen domain containing) 110847-0.0680.0689No
117CALM3NACALM3
Entrez,  Source
calmodulin 3 (phosphorylase kinase, delta)10866-0.0690.0684No
118APOA4NAAPOA4
Entrez,  Source
apolipoprotein A-IV10882-0.0700.0681No
119PIK3R5NAPIK3R5
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 5, p10111049-0.0810.0594No
120CXCL1NACXCL1
Entrez,  Source
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)11070-0.0820.0589No
121PRSS3NAPRSS3
Entrez,  Source
protease, serine, 3 (mesotrypsin)11091-0.0830.0584No
122CPMNACPM
Entrez,  Source
carboxypeptidase M11299-0.0980.0476No
123DUSP6NADUSP6
Entrez,  Source
dual specificity phosphatase 611523-0.1160.0360No
124ATOX1NAATOX1
Entrez,  Source
ATX1 antioxidant protein 1 homolog (yeast)11534-0.1170.0363No
125FDX1NAFDX1
Entrez,  Source
ferredoxin 111801-0.1400.0225No
126LCP2NALCP2
Entrez,  Source
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)11815-0.1410.0228No
127TFPI2NATFPI2
Entrez,  Source
tissue factor pathway inhibitor 211859-0.1450.0214No
128NOTCH4NANOTCH4
Entrez,  Source
Notch homolog 4 (Drosophila)12030-0.1580.0131No
129PCSK9NAPCSK9
Entrez,  Source
proprotein convertase subtilisin/kexin type 912045-0.1590.0134No
130F7NAF7
Entrez,  Source
coagulation factor VII (serum prothrombin conversion accelerator)12061-0.1610.0138No
131DOCK9NADOCK9
Entrez,  Source
dedicator of cytokinesis 912232-0.1760.0056No
132CR2NACR2
Entrez,  Source
complement component (3d/Epstein Barr virus) receptor 212243-0.1770.0063No
133PRCPNAPRCP
Entrez,  Source
prolylcarboxypeptidase (angiotensinase C)12414-0.192-0.0018No
134CDANACDA
Entrez,  Source
cytidine deaminase12461-0.197-0.0030No
135ME1NAME1
Entrez,  Source
malic enzyme 1, NADP(+)-dependent, cytosolic12526-0.204-0.0051No
136DGKHNADGKH
Entrez,  Source
diacylglycerol kinase, eta12558-0.207-0.0053No
137APOBEC3FNAAPOBEC3F
Entrez,  Source
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F13464-0.289-0.0536No
138FYNNAFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES13562-0.297-0.0569No
139CTSCNACTSC
Entrez,  Source
cathepsin C13770-0.317-0.0661No
140SERPING1NASERPING1
Entrez,  Source
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)13833-0.324-0.0673No
141SERPINA1NASERPINA1
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 113846-0.325-0.0656No
142RAF1NARAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 113934-0.335-0.0681No
143GRB2NAGRB2
Entrez,  Source
growth factor receptor-bound protein 214005-0.345-0.0695No
144KYNUNAKYNU
Entrez,  Source
kynureninase (L-kynurenine hydrolase)14108-0.358-0.0726No
145PLA2G7NAPLA2G7
Entrez,  Source
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)14283-0.378-0.0796No
146RASGRP1NARASGRP1
Entrez,  Source
RAS guanyl releasing protein 1 (calcium and DAG-regulated)14367-0.387-0.0814No
147CDH13NACDH13
Entrez,  Source
cadherin 13, H-cadherin (heart)14418-0.393-0.0814No
148ADRA2BNAADRA2B
Entrez,  Source
adrenergic, alpha-2B-, receptor14460-0.400-0.0808No
149DGKGNADGKG
Entrez,  Source
diacylglycerol kinase, gamma 90kDa14471-0.401-0.0785No
150S100A12NAS100A12
Entrez,  Source
S100 calcium binding protein A1214473-0.402-0.0757No
151CTSBNACTSB
Entrez,  Source
cathepsin B14594-0.418-0.0794No
152LTA4HNALTA4H
Entrez,  Source
leukotriene A4 hydrolase14632-0.422-0.0784No
153F2NAF2
Entrez,  Source
coagulation factor II (thrombin)14879-0.459-0.0888No
154GZMANAGZMA
Entrez,  Source
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)14995-0.474-0.0919No
155PLA2G4ANAPLA2G4A
Entrez,  Source
phospholipase A2, group IVA (cytosolic, calcium-dependent)15413-0.535-0.1112No
156S100A13NAS100A13
Entrez,  Source
S100 calcium binding protein A1315415-0.535-0.1075No
157KCNIP3NAKCNIP3
Entrez,  Source
Kv channel interacting protein 3, calsenilin15417-0.535-0.1037No
158LAMP2NALAMP2
Entrez,  Source
lysosomal-associated membrane protein 215452-0.543-0.1017No
159GP9NAGP9
Entrez,  Source
glycoprotein IX (platelet)15458-0.543-0.0981No
160ACTN2NAACTN2
Entrez,  Source
actinin, alpha 215627-0.577-0.1034No
161CPNACP
Entrez,  Source
ceruloplasmin (ferroxidase)15638-0.579-0.0998No
162ITIH1NAITIH1
Entrez,  Source
inter-alpha (globulin) inhibitor H115961-0.644-0.1131No
163CR1NACR1
Entrez,  Source
complement component (3b/4b) receptor 1 (Knops blood group)15977-0.651-0.1093No
164GNB4NAGNB4
Entrez,  Source
guanine nucleotide binding protein (G protein), beta polypeptide 416041-0.666-0.1080No
165ANGNAANG
Entrez,  Source
angiogenin, ribonuclease, RNase A family, 516068-0.672-0.1047No
166PLEKNAPLEK
Entrez,  Source
pleckstrin16096-0.680-0.1013No
167KLKB1NAKLKB1
Entrez,  Source
kallikrein B, plasma (Fletcher factor) 116098-0.680-0.0965No
168L3MBTL4NAL3MBTL4
Entrez,  Source
l(3)mbt-like 4 (Drosophila)16187-0.702-0.0964No
169MMP13NAMMP13
Entrez,  Source
matrix metallopeptidase 13 (collagenase 3)16332-0.741-0.0991No
170C3NAC3
Entrez,  Source
complement component 316387-0.761-0.0967No
171GMFBNAGMFB
Entrez,  Source
glia maturation factor, beta16550-0.812-0.0999No
172KCNIP2NAKCNIP2
Entrez,  Source
Kv channel interacting protein 216588-0.823-0.0961No
173TIMP2NATIMP2
Entrez,  Source
TIMP metallopeptidase inhibitor 216590-0.824-0.0903No
174SCG3NASCG3
Entrez,  Source
secretogranin III16654-0.840-0.0878No
175CD46NACD46
Entrez,  Source
CD46 molecule, complement regulatory protein16711-0.856-0.0848No
176PLGNAPLG
Entrez,  Source
plasminogen16761-0.873-0.0813No
177LRP1NALRP1
Entrez,  Source
low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)16858-0.907-0.0801No
178GP1BANAGP1BA
Entrez,  Source
glycoprotein Ib (platelet), alpha polypeptide16892-0.922-0.0754No
179ADAM9NAADAM9
Entrez,  Source
ADAM metallopeptidase domain 9 (meltrin gamma)16903-0.928-0.0693No
180KLK1NAKLK1
Entrez,  Source
kallikrein 1, renal/pancreas/salivary16961-0.952-0.0657No
181CD36NACD36
Entrez,  Source
CD36 molecule (thrombospondin receptor)17086-1.007-0.0654No
182PIM1NAPIM1
Entrez,  Source
pim-1 oncogene17087-1.007-0.0582No
183C1SNAC1S
Entrez,  Source
complement component 1, s subcomponent17205-1.061-0.0571No
184CD59NACD59
Entrez,  Source
CD59 molecule, complement regulatory protein17237-1.080-0.0511No
185F10NAF10
Entrez,  Source
coagulation factor X17562-1.308-0.0598No
186PIK3CGNAPIK3CG
Entrez,  Source
phosphoinositide-3-kinase, catalytic, gamma polypeptide17630-1.385-0.0537No
187CASP9NACASP9
Entrez,  Source
caspase 9, apoptosis-related cysteine peptidase17671-1.437-0.0456No
188C1RNAC1R
Entrez,  Source
complement component 1, r subcomponent17902-1.865-0.0451No
189PHEXNAPHEX
Entrez,  Source
phosphate regulating endopeptidase homolog, X-linked (hypophosphatemia, vitamin D resistant rickets)17918-1.903-0.0324No
190CFHNACFH
Entrez,  Source
complement factor H18095-2.940-0.0212No
191MMP12NAMMP12
Entrez,  Source
matrix metallopeptidase 12 (macrophage elastase)18133-3.5180.0019No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_COMPLEMENT   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_COMPLEMENT: Random ES distribution   
Gene set null distribution of ES for HALLMARK_COMPLEMENT