Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_COAGULATION |
| Enrichment Score (ES) | -0.26644677 |
| Normalized Enrichment Score (NES) | -1.0769681 |
| Nominal p-value | 0.27688172 |
| FDR q-value | 0.33305505 |
| FWER p-Value | 0.995 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | ACOX2 | NA | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 53 | 3.977 | 0.0378 | No |
| 2 | CFB | NA | CFB Entrez, Source | complement factor B | 67 | 3.669 | 0.0746 | No |
| 3 | OLR1 | NA | OLR1 Entrez, Source | oxidised low density lipoprotein (lectin-like) receptor 1 | 130 | 2.873 | 0.1006 | No |
| 4 | ITGA2 | NA | ITGA2 Entrez, Source | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 148 | 2.720 | 0.1275 | No |
| 5 | SERPINE1 | NA | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 290 | 2.039 | 0.1406 | No |
| 6 | F3 | NA | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 301 | 1.981 | 0.1603 | No |
| 7 | THBD | NA | THBD Entrez, Source | thrombomodulin | 429 | 1.656 | 0.1702 | No |
| 8 | PRSS23 | NA | PRSS23 Entrez, Source | protease, serine, 23 | 524 | 1.516 | 0.1806 | No |
| 9 | VWF | NA | VWF Entrez, Source | von Willebrand factor | 689 | 1.332 | 0.1851 | No |
| 10 | FN1 | NA | FN1 Entrez, Source | fibronectin 1 | 803 | 1.244 | 0.1916 | No |
| 11 | SERPINC1 | NA | SERPINC1 Entrez, Source | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 846 | 1.211 | 0.2016 | No |
| 12 | THBS1 | NA | THBS1 Entrez, Source | thrombospondin 1 | 860 | 1.202 | 0.2132 | No |
| 13 | CAPN5 | NA | CAPN5 Entrez, Source | calpain 5 | 1190 | 1.027 | 0.2055 | No |
| 14 | MAFF | NA | MAFF Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) | 1237 | 1.004 | 0.2132 | No |
| 15 | C8G | NA | C8G Entrez, Source | complement component 8, gamma polypeptide | 1405 | 0.945 | 0.2137 | No |
| 16 | CTSO | NA | CTSO Entrez, Source | cathepsin O | 1466 | 0.920 | 0.2198 | No |
| 17 | F12 | NA | F12 Entrez, Source | coagulation factor XII (Hageman factor) | 1541 | 0.899 | 0.2249 | No |
| 18 | CTSE | NA | CTSE Entrez, Source | cathepsin E | 1747 | 0.839 | 0.2221 | No |
| 19 | RAPGEF3 | NA | RAPGEF3 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 3 | 1878 | 0.813 | 0.2232 | No |
| 20 | CSRP1 | NA | CSRP1 Entrez, Source | cysteine and glycine-rich protein 1 | 2030 | 0.783 | 0.2228 | No |
| 21 | CAPN2 | NA | CAPN2 Entrez, Source | calpain 2, (m/II) large subunit | 2083 | 0.769 | 0.2278 | No |
| 22 | P2RY1 | NA | P2RY1 Entrez, Source | purinergic receptor P2Y, G-protein coupled, 1 | 2089 | 0.768 | 0.2354 | No |
| 23 | FGA | NA | FGA Entrez, Source | fibrinogen alpha chain | 2283 | 0.727 | 0.2322 | No |
| 24 | ANXA1 | NA | ANXA1 Entrez, Source | annexin A1 | 2327 | 0.718 | 0.2371 | No |
| 25 | F13B | NA | F13B Entrez, Source | coagulation factor XIII, B polypeptide | 2416 | 0.700 | 0.2394 | No |
| 26 | USP11 | NA | USP11 Entrez, Source | ubiquitin specific peptidase 11 | 2671 | 0.653 | 0.2320 | No |
| 27 | RABIF | NA | RABIF Entrez, Source | RAB interacting factor | 2716 | 0.647 | 0.2362 | No |
| 28 | GNB2 | NA | GNB2 Entrez, Source | guanine nucleotide binding protein (G protein), beta polypeptide 2 | 2751 | 0.639 | 0.2409 | No |
| 29 | CTSH | NA | CTSH Entrez, Source | cathepsin H | 3063 | 0.587 | 0.2297 | No |
| 30 | FBN1 | NA | FBN1 Entrez, Source | fibrillin 1 | 3082 | 0.584 | 0.2346 | No |
| 31 | PEF1 | NA | PEF1 Entrez, Source | penta-EF-hand domain containing 1 | 3130 | 0.578 | 0.2379 | No |
| 32 | CRIP2 | NA | CRIP2 Entrez, Source | cysteine-rich protein 2 | 3144 | 0.576 | 0.2431 | No |
| 33 | SH2B2 | NA | SH2B2 Entrez, Source | SH2B adaptor protein 2 | 3326 | 0.547 | 0.2387 | No |
| 34 | LEFTY2 | NA | LEFTY2 Entrez, Source | left-right determination factor 2 | 3520 | 0.520 | 0.2333 | No |
| 35 | TIMP1 | NA | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 3797 | 0.486 | 0.2230 | No |
| 36 | TIMP3 | NA | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 3807 | 0.484 | 0.2274 | No |
| 37 | PECAM1 | NA | PECAM1 Entrez, Source | platelet/endothelial cell adhesion molecule (CD31 antigen) | 4061 | 0.454 | 0.2181 | No |
| 38 | PLAT | NA | PLAT Entrez, Source | plasminogen activator, tissue | 4378 | 0.414 | 0.2048 | No |
| 39 | C8A | NA | C8A Entrez, Source | complement component 8, alpha polypeptide | 4637 | 0.388 | 0.1944 | No |
| 40 | ARF4 | NA | ARF4 Entrez, Source | ADP-ribosylation factor 4 | 4743 | 0.378 | 0.1925 | No |
| 41 | WDR1 | NA | WDR1 Entrez, Source | WD repeat domain 1 | 4858 | 0.366 | 0.1899 | No |
| 42 | CFD | NA | CFD Entrez, Source | complement factor D (adipsin) | 4915 | 0.360 | 0.1905 | No |
| 43 | LGMN | NA | LGMN Entrez, Source | legumain | 5043 | 0.347 | 0.1870 | No |
| 44 | HNF4A | NA | HNF4A Entrez, Source | hepatocyte nuclear factor 4, alpha | 5083 | 0.343 | 0.1884 | No |
| 45 | C2 | NA | C2 Entrez, Source | complement component 2 | 5139 | 0.338 | 0.1888 | No |
| 46 | MEP1A | NA | MEP1A Entrez, Source | meprin A, alpha (PABA peptide hydrolase) | 5552 | 0.299 | 0.1690 | No |
| 47 | C9 | NA | C9 Entrez, Source | complement component 9 | 5665 | 0.290 | 0.1657 | No |
| 48 | PREP | NA | PREP Entrez, Source | prolyl endopeptidase | 5688 | 0.287 | 0.1675 | No |
| 49 | MMP8 | NA | MMP8 Entrez, Source | matrix metallopeptidase 8 (neutrophil collagenase) | 5909 | 0.269 | 0.1580 | No |
| 50 | MMP3 | NA | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 6155 | 0.250 | 0.1470 | No |
| 51 | MMP15 | NA | MMP15 Entrez, Source | matrix metallopeptidase 15 (membrane-inserted) | 6328 | 0.234 | 0.1399 | No |
| 52 | MMP2 | NA | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 6602 | 0.212 | 0.1269 | No |
| 53 | MMP1 | NA | MMP1 Entrez, Source | matrix metallopeptidase 1 (interstitial collagenase) | 7053 | 0.176 | 0.1037 | No |
| 54 | HPN | NA | HPN Entrez, Source | hepsin (transmembrane protease, serine 1) | 7236 | 0.164 | 0.0953 | No |
| 55 | APOC1 | NA | APOC1 Entrez, Source | apolipoprotein C-I | 7252 | 0.163 | 0.0962 | No |
| 56 | DPP4 | NA | DPP4 Entrez, Source | dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2) | 8203 | 0.093 | 0.0444 | No |
| 57 | HRG | NA | HRG Entrez, Source | histidine-rich glycoprotein | 8257 | 0.089 | 0.0424 | No |
| 58 | PF4 | NA | PF4 Entrez, Source | platelet factor 4 (chemokine (C-X-C motif) ligand 4) | 8263 | 0.089 | 0.0430 | No |
| 59 | MMP11 | NA | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 8926 | 0.042 | 0.0068 | No |
| 60 | TMPRSS6 | NA | TMPRSS6 Entrez, Source | transmembrane protease, serine 6 | 9172 | 0.022 | -0.0066 | No |
| 61 | COMP | NA | COMP Entrez, Source | cartilage oligomeric matrix protein | 9348 | 0.011 | -0.0162 | No |
| 62 | F8 | NA | F8 Entrez, Source | coagulation factor VIII, procoagulant component (hemophilia A) | 9357 | 0.011 | -0.0165 | No |
| 63 | C1QA | NA | C1QA Entrez, Source | complement component 1, q subcomponent, A chain | 9581 | 0.000 | -0.0289 | No |
| 64 | F2RL2 | NA | F2RL2 Entrez, Source | coagulation factor II (thrombin) receptor-like 2 | 9769 | -0.003 | -0.0392 | No |
| 65 | SERPINB2 | NA | SERPINB2 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 9790 | -0.005 | -0.0403 | No |
| 66 | PROZ | NA | PROZ Entrez, Source | protein Z, vitamin K-dependent plasma glycoprotein | 9805 | -0.007 | -0.0410 | No |
| 67 | PDGFB | NA | PDGFB Entrez, Source | platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) | 9832 | -0.008 | -0.0423 | No |
| 68 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 9857 | -0.010 | -0.0436 | No |
| 69 | KLK8 | NA | KLK8 Entrez, Source | kallikrein 8 (neuropsin/ovasin) | 9984 | -0.018 | -0.0504 | No |
| 70 | MMP7 | NA | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 10022 | -0.020 | -0.0522 | No |
| 71 | MMP14 | NA | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 10281 | -0.037 | -0.0661 | No |
| 72 | SIRT2 | NA | SIRT2 Entrez, Source | sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) | 10312 | -0.039 | -0.0674 | No |
| 73 | MMP10 | NA | MMP10 Entrez, Source | matrix metallopeptidase 10 (stromelysin 2) | 10346 | -0.040 | -0.0688 | No |
| 74 | FGG | NA | FGG Entrez, Source | fibrinogen gamma chain | 10726 | -0.062 | -0.0892 | No |
| 75 | F9 | NA | F9 Entrez, Source | coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) | 10764 | -0.063 | -0.0906 | No |
| 76 | MST1 | NA | MST1 Entrez, Source | macrophage stimulating 1 (hepatocyte growth factor-like) | 11026 | -0.079 | -0.1043 | No |
| 77 | C8B | NA | C8B Entrez, Source | complement component 8, beta polypeptide | 11187 | -0.090 | -0.1122 | No |
| 78 | DUSP6 | NA | DUSP6 Entrez, Source | dual specificity phosphatase 6 | 11523 | -0.116 | -0.1296 | No |
| 79 | TFPI2 | NA | TFPI2 Entrez, Source | tissue factor pathway inhibitor 2 | 11859 | -0.145 | -0.1467 | No |
| 80 | CPB2 | NA | CPB2 Entrez, Source | carboxypeptidase B2 (plasma, carboxypeptidase U) | 12825 | -0.228 | -0.1979 | No |
| 81 | MMP9 | NA | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 13001 | -0.245 | -0.2051 | No |
| 82 | ISCU | NA | 13050 | -0.249 | -0.2052 | No | ||
| 83 | HMGCS2 | NA | HMGCS2 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 13152 | -0.258 | -0.2081 | No |
| 84 | APOA1 | NA | APOA1 Entrez, Source | apolipoprotein A-I | 13168 | -0.259 | -0.2063 | No |
| 85 | FYN | NA | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 13562 | -0.297 | -0.2251 | No |
| 86 | TF | NA | TF Entrez, Source | transferrin | 13628 | -0.305 | -0.2256 | No |
| 87 | SERPING1 | NA | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 13833 | -0.324 | -0.2336 | No |
| 88 | CTSK | NA | CTSK Entrez, Source | cathepsin K (pycnodysostosis) | 13842 | -0.325 | -0.2307 | No |
| 89 | SERPINA1 | NA | SERPINA1 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 13846 | -0.325 | -0.2275 | No |
| 90 | FURIN | NA | FURIN Entrez, Source | furin (paired basic amino acid cleaving enzyme) | 13866 | -0.327 | -0.2252 | No |
| 91 | PROC | NA | PROC Entrez, Source | protein C (inactivator of coagulation factors Va and VIIIa) | 13938 | -0.336 | -0.2257 | No |
| 92 | APOC2 | NA | APOC2 Entrez, Source | apolipoprotein C-II | 14105 | -0.357 | -0.2313 | No |
| 93 | F11 | NA | F11 Entrez, Source | coagulation factor XI (plasma thromboplastin antecedent) | 14109 | -0.358 | -0.2278 | No |
| 94 | BMP1 | NA | BMP1 Entrez, Source | bone morphogenetic protein 1 | 14153 | -0.364 | -0.2264 | No |
| 95 | DUSP14 | NA | DUSP14 Entrez, Source | dual specificity phosphatase 14 | 14550 | -0.413 | -0.2442 | No |
| 96 | CTSB | NA | CTSB Entrez, Source | cathepsin B | 14594 | -0.418 | -0.2423 | No |
| 97 | LTA4H | NA | LTA4H Entrez, Source | leukotriene A4 hydrolase | 14632 | -0.422 | -0.2400 | No |
| 98 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 14763 | -0.438 | -0.2427 | No |
| 99 | S100A1 | NA | S100A1 Entrez, Source | S100 calcium binding protein A1 | 14873 | -0.458 | -0.2441 | No |
| 100 | F2 | NA | F2 Entrez, Source | coagulation factor II (thrombin) | 14879 | -0.459 | -0.2396 | No |
| 101 | DCT | NA | DCT Entrez, Source | dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) | 14925 | -0.465 | -0.2374 | No |
| 102 | GSN | NA | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 15393 | -0.531 | -0.2578 | No |
| 103 | S100A13 | NA | S100A13 Entrez, Source | S100 calcium binding protein A13 | 15415 | -0.535 | -0.2535 | No |
| 104 | LAMP2 | NA | LAMP2 Entrez, Source | lysosomal-associated membrane protein 2 | 15452 | -0.543 | -0.2500 | No |
| 105 | GP9 | NA | GP9 Entrez, Source | glycoprotein IX (platelet) | 15458 | -0.543 | -0.2447 | No |
| 106 | MBL2 | NA | MBL2 Entrez, Source | mannose-binding lectin (protein C) 2, soluble (opsonic defect) | 15678 | -0.586 | -0.2508 | No |
| 107 | ITIH1 | NA | ITIH1 Entrez, Source | inter-alpha (globulin) inhibitor H1 | 15961 | -0.644 | -0.2598 | Yes |
| 108 | KLF7 | NA | KLF7 Entrez, Source | Kruppel-like factor 7 (ubiquitous) | 15995 | -0.655 | -0.2550 | Yes |
| 109 | CPN1 | NA | CPN1 Entrez, Source | carboxypeptidase N, polypeptide 1, 50kD | 16064 | -0.671 | -0.2519 | Yes |
| 110 | ANG | NA | ANG Entrez, Source | angiogenin, ribonuclease, RNase A family, 5 | 16068 | -0.672 | -0.2451 | Yes |
| 111 | PLEK | NA | PLEK Entrez, Source | pleckstrin | 16096 | -0.680 | -0.2397 | Yes |
| 112 | KLKB1 | NA | KLKB1 Entrez, Source | kallikrein B, plasma (Fletcher factor) 1 | 16098 | -0.680 | -0.2328 | Yes |
| 113 | PLAU | NA | PLAU Entrez, Source | plasminogen activator, urokinase | 16140 | -0.690 | -0.2280 | Yes |
| 114 | CD9 | NA | CD9 Entrez, Source | CD9 molecule | 16232 | -0.715 | -0.2257 | Yes |
| 115 | C3 | NA | C3 Entrez, Source | complement component 3 | 16387 | -0.761 | -0.2265 | Yes |
| 116 | MSRB2 | NA | MSRB2 Entrez, Source | methionine sulfoxide reductase B2 | 16405 | -0.766 | -0.2196 | Yes |
| 117 | PLG | NA | PLG Entrez, Source | plasminogen | 16761 | -0.873 | -0.2303 | Yes |
| 118 | LRP1 | NA | LRP1 Entrez, Source | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | 16858 | -0.907 | -0.2263 | Yes |
| 119 | GP1BA | NA | GP1BA Entrez, Source | glycoprotein Ib (platelet), alpha polypeptide | 16892 | -0.922 | -0.2187 | Yes |
| 120 | ADAM9 | NA | ADAM9 Entrez, Source | ADAM metallopeptidase domain 9 (meltrin gamma) | 16903 | -0.928 | -0.2098 | Yes |
| 121 | MASP2 | NA | MASP2 Entrez, Source | mannan-binding lectin serine peptidase 2 | 17100 | -1.016 | -0.2102 | Yes |
| 122 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 17205 | -1.061 | -0.2051 | Yes |
| 123 | HTRA1 | NA | HTRA1 Entrez, Source | HtrA serine peptidase 1 | 17320 | -1.130 | -0.1999 | Yes |
| 124 | RGN | NA | RGN Entrez, Source | regucalcin (senescence marker protein-30) | 17378 | -1.171 | -0.1911 | Yes |
| 125 | GNG12 | NA | GNG12 Entrez, Source | guanine nucleotide binding protein (G protein), gamma 12 | 17398 | -1.191 | -0.1799 | Yes |
| 126 | F10 | NA | F10 Entrez, Source | coagulation factor X | 17562 | -1.308 | -0.1756 | Yes |
| 127 | CASP9 | NA | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 17671 | -1.437 | -0.1668 | Yes |
| 128 | GDA | NA | GDA Entrez, Source | guanine deaminase | 17746 | -1.525 | -0.1553 | Yes |
| 129 | C1R | NA | C1R Entrez, Source | complement component 1, r subcomponent | 17902 | -1.865 | -0.1448 | Yes |
| 130 | SPARC | NA | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 17975 | -2.121 | -0.1271 | Yes |
| 131 | A2M | NA | A2M Entrez, Source | alpha-2-macroglobulin | 18074 | -2.760 | -0.1043 | Yes |
| 132 | CFH | NA | CFH Entrez, Source | complement factor H | 18095 | -2.940 | -0.0753 | Yes |
| 133 | PROS1 | NA | PROS1 Entrez, Source | protein S (alpha) | 18136 | -3.580 | -0.0408 | Yes |
| 134 | CFI | NA | CFI Entrez, Source | complement factor I | 18152 | -4.148 | 0.0008 | Yes |
