Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_BILE_ACID_METABOLISM |
| Enrichment Score (ES) | -0.35718802 |
| Normalized Enrichment Score (NES) | -1.4158156 |
| Nominal p-value | 0.016620498 |
| FDR q-value | 0.08618684 |
| FWER p-Value | 0.297 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | BCAR3 | NA | BCAR3 Entrez, Source | breast cancer anti-estrogen resistance 3 | 791 | 1.254 | -0.0206 | No |
| 2 | GCLM | NA | GCLM Entrez, Source | glutamate-cysteine ligase, modifier subunit | 812 | 1.238 | 0.0011 | No |
| 3 | RXRG | NA | RXRG Entrez, Source | retinoid X receptor, gamma | 894 | 1.179 | 0.0185 | No |
| 4 | DIO1 | NA | DIO1 Entrez, Source | deiodinase, iodothyronine, type I | 1227 | 1.009 | 0.0187 | No |
| 5 | NPC1 | NA | NPC1 Entrez, Source | Niemann-Pick disease, type C1 | 1366 | 0.957 | 0.0288 | No |
| 6 | ABCA5 | NA | ABCA5 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 5 | 1523 | 0.904 | 0.0368 | No |
| 7 | PEX16 | NA | PEX16 Entrez, Source | peroxisomal biogenesis factor 16 | 1864 | 0.816 | 0.0331 | No |
| 8 | ABCD1 | NA | ABCD1 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 1 | 2274 | 0.729 | 0.0239 | No |
| 9 | CYP7A1 | NA | CYP7A1 Entrez, Source | cytochrome P450, family 7, subfamily A, polypeptide 1 | 2619 | 0.663 | 0.0171 | No |
| 10 | RETSAT | NA | RETSAT Entrez, Source | retinol saturase (all-trans-retinol 13,14-reductase) | 2802 | 0.630 | 0.0187 | No |
| 11 | RXRA | NA | RXRA Entrez, Source | retinoid X receptor, alpha | 2835 | 0.626 | 0.0284 | No |
| 12 | AR | NA | AR Entrez, Source | androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) | 2850 | 0.623 | 0.0392 | No |
| 13 | ABCG4 | NA | ABCG4 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 4 | 3076 | 0.585 | 0.0375 | No |
| 14 | SLC27A2 | NA | SLC27A2 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 2 | 3493 | 0.523 | 0.0242 | No |
| 15 | NEDD4 | NA | NEDD4 Entrez, Source | neural precursor cell expressed, developmentally down-regulated 4 | 3691 | 0.498 | 0.0224 | No |
| 16 | NR0B2 | NA | NR0B2 Entrez, Source | nuclear receptor subfamily 0, group B, member 2 | 3696 | 0.498 | 0.0314 | No |
| 17 | ALDH8A1 | NA | ALDH8A1 Entrez, Source | aldehyde dehydrogenase 8 family, member A1 | 3828 | 0.483 | 0.0331 | No |
| 18 | ABCA6 | NA | ABCA6 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 6 | 3834 | 0.482 | 0.0417 | No |
| 19 | SLC29A1 | NA | SLC29A1 Entrez, Source | solute carrier family 29 (nucleoside transporters), member 1 | 4191 | 0.435 | 0.0300 | No |
| 20 | FADS2 | NA | FADS2 Entrez, Source | fatty acid desaturase 2 | 4320 | 0.420 | 0.0307 | No |
| 21 | AMACR | NA | AMACR Entrez, Source | alpha-methylacyl-CoA racemase | 4480 | 0.402 | 0.0293 | No |
| 22 | CYP46A1 | NA | CYP46A1 Entrez, Source | cytochrome P450, family 46, subfamily A, polypeptide 1 | 4798 | 0.372 | 0.0187 | No |
| 23 | BBOX1 | NA | BBOX1 Entrez, Source | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 4860 | 0.366 | 0.0220 | No |
| 24 | PEX12 | NA | PEX12 Entrez, Source | peroxisomal biogenesis factor 12 | 4899 | 0.362 | 0.0266 | No |
| 25 | PAOX | NA | PAOX Entrez, Source | polyamine oxidase (exo-N4-amino) | 5089 | 0.342 | 0.0225 | No |
| 26 | MLYCD | NA | MLYCD Entrez, Source | malonyl-CoA decarboxylase | 5093 | 0.342 | 0.0286 | No |
| 27 | HSD17B6 | NA | HSD17B6 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 6 | 5126 | 0.339 | 0.0331 | No |
| 28 | OPTN | NA | OPTN Entrez, Source | optineurin | 5260 | 0.326 | 0.0318 | No |
| 29 | LONP2 | NA | 5295 | 0.323 | 0.0359 | No | ||
| 30 | SULT1B1 | NA | SULT1B1 Entrez, Source | sulfotransferase family, cytosolic, 1B, member 1 | 5535 | 0.301 | 0.0282 | No |
| 31 | PEX1 | NA | PEX1 Entrez, Source | peroxisome biogenesis factor 1 | 5682 | 0.288 | 0.0255 | No |
| 32 | HAO1 | NA | HAO1 Entrez, Source | hydroxyacid oxidase (glycolate oxidase) 1 | 6173 | 0.248 | 0.0029 | No |
| 33 | LCK | NA | LCK Entrez, Source | lymphocyte-specific protein tyrosine kinase | 6635 | 0.208 | -0.0188 | No |
| 34 | CYP8B1 | NA | CYP8B1 Entrez, Source | cytochrome P450, family 8, subfamily B, polypeptide 1 | 6865 | 0.191 | -0.0280 | No |
| 35 | CROT | NA | CROT Entrez, Source | carnitine O-octanoyltransferase | 6903 | 0.188 | -0.0265 | No |
| 36 | ACSL5 | NA | ACSL5 Entrez, Source | acyl-CoA synthetase long-chain family member 5 | 6933 | 0.185 | -0.0247 | No |
| 37 | HSD3B7 | NA | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 7819 | 0.121 | -0.0715 | No |
| 38 | PEX6 | NA | PEX6 Entrez, Source | peroxisomal biogenesis factor 6 | 7887 | 0.116 | -0.0731 | No |
| 39 | RBP1 | NA | RBP1 Entrez, Source | retinol binding protein 1, cellular | 7948 | 0.111 | -0.0743 | No |
| 40 | AKR1D1 | NA | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 7965 | 0.110 | -0.0732 | No |
| 41 | GNPAT | NA | GNPAT Entrez, Source | glyceronephosphate O-acyltransferase | 8028 | 0.105 | -0.0747 | No |
| 42 | ABCA4 | NA | ABCA4 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 4 | 8069 | 0.102 | -0.0750 | No |
| 43 | DIO2 | NA | DIO2 Entrez, Source | deiodinase, iodothyronine, type II | 8100 | 0.099 | -0.0749 | No |
| 44 | TTR | NA | TTR Entrez, Source | transthyretin (prealbumin, amyloidosis type I) | 8177 | 0.094 | -0.0773 | No |
| 45 | DHCR24 | NA | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 8233 | 0.091 | -0.0787 | No |
| 46 | SLC23A2 | NA | SLC23A2 Entrez, Source | solute carrier family 23 (nucleobase transporters), member 2 | 8258 | 0.089 | -0.0784 | No |
| 47 | PHYH | NA | PHYH Entrez, Source | phytanoyl-CoA 2-hydroxylase | 8368 | 0.081 | -0.0829 | No |
| 48 | GSTK1 | NA | GSTK1 Entrez, Source | glutathione S-transferase kappa 1 | 8511 | 0.071 | -0.0895 | No |
| 49 | CYP27A1 | NA | CYP27A1 Entrez, Source | cytochrome P450, family 27, subfamily A, polypeptide 1 | 8777 | 0.052 | -0.1032 | No |
| 50 | ABCD2 | NA | ABCD2 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 2 | 8992 | 0.035 | -0.1144 | No |
| 51 | SLC35B2 | NA | SLC35B2 Entrez, Source | solute carrier family 35, member B2 | 8997 | 0.035 | -0.1140 | No |
| 52 | PEX11A | NA | PEX11A Entrez, Source | peroxisomal biogenesis factor 11A | 9043 | 0.032 | -0.1159 | No |
| 53 | ABCA8 | NA | ABCA8 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 8 | 9422 | 0.005 | -0.1367 | No |
| 54 | PRDX5 | NA | PRDX5 Entrez, Source | peroxiredoxin 5 | 9470 | 0.003 | -0.1393 | No |
| 55 | CYP7B1 | NA | CYP7B1 Entrez, Source | cytochrome P450, family 7, subfamily B, polypeptide 1 | 9823 | -0.008 | -0.1586 | No |
| 56 | PXMP2 | NA | PXMP2 Entrez, Source | peroxisomal membrane protein 2, 22kDa | 9908 | -0.013 | -0.1630 | No |
| 57 | SERPINA6 | NA | SERPINA6 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 | 9983 | -0.018 | -0.1668 | No |
| 58 | PEX19 | NA | PEX19 Entrez, Source | peroxisomal biogenesis factor 19 | 10008 | -0.018 | -0.1678 | No |
| 59 | HSD17B11 | NA | 10104 | -0.026 | -0.1725 | No | ||
| 60 | GNMT | NA | GNMT Entrez, Source | glycine N-methyltransferase | 10117 | -0.027 | -0.1727 | No |
| 61 | FDXR | NA | FDXR Entrez, Source | ferredoxin reductase | 10185 | -0.030 | -0.1759 | No |
| 62 | LIPE | NA | LIPE Entrez, Source | lipase, hormone-sensitive | 10196 | -0.031 | -0.1758 | No |
| 63 | CH25H | NA | CH25H Entrez, Source | cholesterol 25-hydroxylase | 10820 | -0.066 | -0.2091 | No |
| 64 | PNPLA8 | NA | PNPLA8 Entrez, Source | patatin-like phospholipase domain containing 8 | 10963 | -0.075 | -0.2156 | No |
| 65 | ABCG8 | NA | ABCG8 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2) | 11094 | -0.084 | -0.2213 | No |
| 66 | SLCO1A2 | NA | SLCO1A2 Entrez, Source | solute carrier organic anion transporter family, member 1A2 | 11123 | -0.086 | -0.2212 | No |
| 67 | GC | NA | GC Entrez, Source | group-specific component (vitamin D binding protein) | 11249 | -0.095 | -0.2264 | No |
| 68 | ABCA9 | NA | ABCA9 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 9 | 11865 | -0.145 | -0.2578 | No |
| 69 | SLC27A5 | NA | SLC27A5 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 5 | 11946 | -0.151 | -0.2594 | No |
| 70 | FADS1 | NA | FADS1 Entrez, Source | fatty acid desaturase 1 | 12002 | -0.156 | -0.2596 | No |
| 71 | ALDH1A1 | NA | ALDH1A1 Entrez, Source | aldehyde dehydrogenase 1 family, member A1 | 12537 | -0.205 | -0.2854 | No |
| 72 | TFCP2L1 | NA | TFCP2L1 Entrez, Source | transcription factor CP2-like 1 | 12640 | -0.214 | -0.2871 | No |
| 73 | KLF1 | NA | KLF1 Entrez, Source | Kruppel-like factor 1 (erythroid) | 12670 | -0.217 | -0.2847 | No |
| 74 | SOAT2 | NA | SOAT2 Entrez, Source | sterol O-acyltransferase 2 | 12762 | -0.225 | -0.2855 | No |
| 75 | PEX26 | NA | PEX26 Entrez, Source | peroxisome biogenesis factor 26 | 12776 | -0.226 | -0.2821 | No |
| 76 | APOA1 | NA | APOA1 Entrez, Source | apolipoprotein A-I | 13168 | -0.259 | -0.2990 | No |
| 77 | HACL1 | NA | HACL1 Entrez, Source | 2-hydroxyacyl-CoA lyase 1 | 13173 | -0.260 | -0.2944 | No |
| 78 | PFKM | NA | PFKM Entrez, Source | phosphofructokinase, muscle | 13622 | -0.305 | -0.3136 | No |
| 79 | PEX13 | NA | PEX13 Entrez, Source | peroxisome biogenesis factor 13 | 13856 | -0.326 | -0.3204 | No |
| 80 | EPHX2 | NA | EPHX2 Entrez, Source | epoxide hydrolase 2, cytoplasmic | 13870 | -0.327 | -0.3151 | No |
| 81 | NR1H4 | NA | NR1H4 Entrez, Source | nuclear receptor subfamily 1, group H, member 4 | 13880 | -0.328 | -0.3096 | No |
| 82 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 13992 | -0.344 | -0.3093 | No |
| 83 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 13994 | -0.345 | -0.3030 | No |
| 84 | HSD17B4 | NA | HSD17B4 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 4 | 14216 | -0.369 | -0.3085 | No |
| 85 | SLC22A18 | NA | SLC22A18 Entrez, Source | solute carrier family 22 (organic cation transporter), member 18 | 14235 | -0.370 | -0.3026 | No |
| 86 | ISOC1 | NA | ISOC1 Entrez, Source | isochorismatase domain containing 1 | 14630 | -0.422 | -0.3166 | No |
| 87 | SCP2 | NA | SCP2 Entrez, Source | sterol carrier protein 2 | 15228 | -0.506 | -0.3403 | No |
| 88 | IDH1 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 15361 | -0.527 | -0.3379 | No |
| 89 | NR1I2 | NA | NR1I2 Entrez, Source | nuclear receptor subfamily 1, group I, member 2 | 15389 | -0.531 | -0.3296 | No |
| 90 | NUDT12 | NA | NUDT12 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 12 | 15888 | -0.631 | -0.3455 | Yes |
| 91 | PEX7 | NA | PEX7 Entrez, Source | peroxisomal biogenesis factor 7 | 15992 | -0.654 | -0.3391 | Yes |
| 92 | ABCD3 | NA | ABCD3 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 3 | 16108 | -0.682 | -0.3329 | Yes |
| 93 | EFHC1 | NA | EFHC1 Entrez, Source | EF-hand domain (C-terminal) containing 1 | 16122 | -0.686 | -0.3209 | Yes |
| 94 | BMP6 | NA | BMP6 Entrez, Source | bone morphogenetic protein 6 | 16261 | -0.723 | -0.3152 | Yes |
| 95 | ABCA3 | NA | ABCA3 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 3 | 16288 | -0.730 | -0.3032 | Yes |
| 96 | ABCA2 | NA | ABCA2 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 2 | 16614 | -0.831 | -0.3058 | Yes |
| 97 | NR3C2 | NA | NR3C2 Entrez, Source | nuclear receptor subfamily 3, group C, member 2 | 16687 | -0.850 | -0.2941 | Yes |
| 98 | PEX11G | NA | PEX11G Entrez, Source | peroxisomal biogenesis factor 11 gamma | 16923 | -0.936 | -0.2898 | Yes |
| 99 | PECR | NA | PECR Entrez, Source | peroxisomal trans-2-enoyl-CoA reductase | 16941 | -0.944 | -0.2733 | Yes |
| 100 | HSD3B1 | NA | HSD3B1 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | 16953 | -0.949 | -0.2564 | Yes |
| 101 | AQP9 | NA | AQP9 Entrez, Source | aquaporin 9 | 17009 | -0.974 | -0.2414 | Yes |
| 102 | IDI1 | NA | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 17064 | -0.996 | -0.2260 | Yes |
| 103 | CAT | NA | CAT Entrez, Source | catalase | 17167 | -1.043 | -0.2124 | Yes |
| 104 | AGXT | NA | AGXT Entrez, Source | alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) | 17227 | -1.076 | -0.1958 | Yes |
| 105 | CYP39A1 | NA | CYP39A1 Entrez, Source | cytochrome P450, family 39, subfamily A, polypeptide 1 | 17404 | -1.192 | -0.1835 | Yes |
| 106 | SLC23A1 | NA | SLC23A1 Entrez, Source | solute carrier family 23 (nucleobase transporters), member 1 | 17663 | -1.429 | -0.1714 | Yes |
| 107 | ATXN1 | NA | ATXN1 Entrez, Source | ataxin 1 | 17686 | -1.455 | -0.1457 | Yes |
| 108 | SULT2B1 | NA | SULT2B1 Entrez, Source | sulfotransferase family, cytosolic, 2B, member 1 | 17782 | -1.584 | -0.1217 | Yes |
| 109 | PIPOX | NA | PIPOX Entrez, Source | pipecolic acid oxidase | 17785 | -1.592 | -0.0924 | Yes |
| 110 | ACSL1 | NA | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 17864 | -1.764 | -0.0641 | Yes |
| 111 | IDH2 | NA | IDH2 Entrez, Source | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 17869 | -1.770 | -0.0316 | Yes |
| 112 | ABCA1 | NA | ABCA1 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 1 | 18056 | -2.602 | 0.0061 | Yes |
