Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_APOPTOSIS
Enrichment Score (ES)0.444422
Normalized Enrichment Score (NES)1.7379313
Nominal p-value0.0
FDR q-value0.0029051679
FWER p-Value0.016
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_APOPTOSIS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1IGFBP6NAIGFBP6
Entrez,  Source
insulin-like growth factor binding protein 694.7460.0366Yes
2IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)174.5960.0722Yes
3ISG20NAISG20
Entrez,  Source
interferon stimulated exonuclease gene 20kDa194.5610.1078Yes
4PMAIP1NAPMAIP1
Entrez,  Source
phorbol-12-myristate-13-acetate-induced protein 11103.1030.1271Yes
5IRF1NAIRF1
Entrez,  Source
interferon regulatory factor 11123.0670.1510Yes
6BIRC3NABIRC3
Entrez,  Source
baculoviral IAP repeat-containing 31822.4840.1666Yes
7TNFRSF12ANATNFRSF12A
Entrez,  Source
tumor necrosis factor receptor superfamily, member 12A2032.3870.1842Yes
8SOD2NASOD2
Entrez,  Source
superoxide dismutase 2, mitochondrial2632.1240.1975Yes
9TAP1NATAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)3151.9210.2097Yes
10KRT18NAKRT18
Entrez,  Source
keratin 183721.7710.2205Yes
11BIKNABIK
Entrez,  Source
BCL2-interacting killer (apoptosis-inducing)4041.7100.2321Yes
12GNA15NAGNA15
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)5001.5400.2389Yes
13BCL2L1NABCL2L1
Entrez,  Source
BCL2-like 15121.5260.2502Yes
14CD44NACD44
Entrez,  Source
CD44 molecule (Indian blood group)5151.5230.2620Yes
15EREGNAEREG
Entrez,  Source
epiregulin5531.4790.2715Yes
16MCL1NAMCL1
Entrez,  Source
myeloid cell leukemia sequence 1 (BCL2-related)5611.4710.2827Yes
17TGFB2NATGFB2
Entrez,  Source
transforming growth factor, beta 25891.4290.2923Yes
18NEDD9NANEDD9
Entrez,  Source
neural precursor cell expressed, developmentally down-regulated 96431.3760.3002Yes
19IL1ANAIL1A
Entrez,  Source
interleukin 1, alpha6471.3710.3107Yes
20GPX3NAGPX3
Entrez,  Source
glutathione peroxidase 3 (plasma)6881.3320.3189Yes
21JUNNAJUN
Entrez,  Source
jun oncogene7181.3120.3276Yes
22IL1BNAIL1B
Entrez,  Source
interleukin 1, beta7791.2620.3341Yes
23SQSTM1NASQSTM1
Entrez,  Source
sequestosome 17871.2570.3435Yes
24GADD45ANAGADD45A
Entrez,  Source
growth arrest and DNA-damage-inducible, alpha8281.2250.3509Yes
25PEA15NAPEA15
Entrez,  Source
phosphoprotein enriched in astrocytes 158591.2030.3587Yes
26CASP1NACASP1
Entrez,  Source
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)8971.1780.3658Yes
27CASP4NACASP4
Entrez,  Source
caspase 4, apoptosis-related cysteine peptidase9461.1470.3721Yes
28SLC20A1NASLC20A1
Entrez,  Source
solute carrier family 20 (phosphate transporter), member 19621.1380.3802Yes
29BCL10NABCL10
Entrez,  Source
B-cell CLL/lymphoma 1010351.0990.3848Yes
30RELANARELA
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)11501.0470.3866Yes
31TNFNATNF
Entrez,  Source
tumor necrosis factor (TNF superfamily, member 2)12101.0150.3913Yes
32IFITM3NAIFITM3
Entrez,  Source
interferon induced transmembrane protein 3 (1-8U)13610.9590.3905Yes
33CASP2NACASP2
Entrez,  Source
caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2)14650.9210.3920Yes
34CREBBPNACREBBP
Entrez,  Source
CREB binding protein (Rubinstein-Taybi syndrome)15280.9030.3956Yes
35CCNA1NACCNA1
Entrez,  Source
cyclin A115710.8910.4002Yes
36FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)16000.8810.4056Yes
37LMNANALMNA
Entrez,  Source
lamin A/C16170.8760.4115Yes
38GPX1NAGPX1
Entrez,  Source
glutathione peroxidase 118140.8260.4071Yes
39IL18NAIL18
Entrez,  Source
interleukin 18 (interferon-gamma-inducing factor)19110.8050.4081Yes
40H1F0NAH1F0
Entrez,  Source
H1 histone family, member 019440.7990.4126Yes
41GCH1NAGCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)19760.7920.4170Yes
42TGFBR3NATGFBR3
Entrez,  Source
transforming growth factor, beta receptor III (betaglycan, 300kDa)20210.7840.4207Yes
43CASP7NACASP7
Entrez,  Source
caspase 7, apoptosis-related cysteine peptidase21310.7580.4206Yes
44CYLDNACYLD
Entrez,  Source
cylindromatosis (turban tumor syndrome)21580.7520.4250Yes
45DNAJA1NADNAJA1
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily A, member 122150.7410.4277Yes
46DDIT3NADDIT3
Entrez,  Source
DNA-damage-inducible transcript 322750.7290.4302Yes
47RNASELNARNASEL
Entrez,  Source
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)22820.7280.4355Yes
48RARANARARA
Entrez,  Source
retinoic acid receptor, alpha22900.7260.4408Yes
49ANXA1NAANXA1
Entrez,  Source
annexin A123270.7180.4444Yes
50TNFSF10NATNFSF10
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 1024360.6960.4439No
51HSPB1NAHSPB1
Entrez,  Source
heat shock 27kDa protein 127930.6310.4290No
52RETSATNARETSAT
Entrez,  Source
retinol saturase (all-trans-retinol 13,14-reductase)28020.6300.4335No
53BCL2L11NABCL2L11
Entrez,  Source
BCL2-like 11 (apoptosis facilitator)28800.6170.4341No
54CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase29030.6130.4377No
55CD14NACD14
Entrez,  Source
CD14 molecule29180.6100.4417No
56IFNGR1NAIFNGR1
Entrez,  Source
interferon gamma receptor 131510.5750.4333No
57WEE1NAWEE1
Entrez,  Source
WEE1 homolog (S. pombe)32410.5610.4327No
58DNAJC3NADNAJC3
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily C, member 336520.5040.4139No
59ERBB2NAERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)37540.4910.4121No
60TIMP1NATIMP1
Entrez,  Source
TIMP metallopeptidase inhibitor 137970.4860.4136No
61TIMP3NATIMP3
Entrez,  Source
TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)38070.4840.4169No
62TSPONATSPO
Entrez,  Source
translocator protein (18kDa)41480.4410.4015No
63PSEN1NAPSEN1
Entrez,  Source
presenilin 1 (Alzheimer disease 3)42030.4340.4018No
64PLATNAPLAT
Entrez,  Source
plasminogen activator, tissue43780.4140.3954No
65BCAP31NABCAP31
Entrez,  Source
B-cell receptor-associated protein 3144350.4070.3955No
66CCND1NACCND1
Entrez,  Source
cyclin D144400.4070.3985No
67HMOX1NAHMOX1
Entrez,  Source
heme oxygenase (decycling) 151180.3400.3635No
68LEF1NALEF1
Entrez,  Source
lymphoid enhancer-binding factor 152060.3310.3613No
69PAK1NAPAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)54930.3030.3478No
70APPNAAPP
Entrez,  Source
amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)55770.2970.3455No
71CASP8NACASP8
Entrez,  Source
caspase 8, apoptosis-related cysteine peptidase56770.2880.3423No
72PPP2R5BNAPPP2R5B
Entrez,  Source
protein phosphatase 2, regulatory subunit B (B56), beta isoform56840.2880.3442No
73BAXNABAX
Entrez,  Source
BCL2-associated X protein57830.2800.3409No
74DIABLONADIABLO
Entrez,  Source
diablo homolog (Drosophila)58960.2700.3368No
75DNM1LNADNM1L
Entrez,  Source
dynamin 1-like62050.2450.3216No
76DAPNADAP
Entrez,  Source
death-associated protein62280.2430.3223No
77MGMTNAMGMT
Entrez,  Source
O-6-methylguanine-DNA methyltransferase64100.2280.3140No
78CASP6NACASP6
Entrez,  Source
caspase 6, apoptosis-related cysteine peptidase64280.2270.3149No
79MADDNAMADD
Entrez,  Source
MAP-kinase activating death domain64560.2250.3151No
80BRCA1NABRCA1
Entrez,  Source
breast cancer 1, early onset64750.2230.3159No
81CD38NACD38
Entrez,  Source
CD38 molecule64760.2230.3176No
82PSEN2NAPSEN2
Entrez,  Source
presenilin 2 (Alzheimer disease 4)64780.2230.3193No
83MMP2NAMMP2
Entrez,  Source
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)66020.2120.3141No
84DFFANADFFA
Entrez,  Source
DNA fragmentation factor, 45kDa, alpha polypeptide67810.1970.3058No
85CDC25BNACDC25B
Entrez,  Source
cell division cycle 25B69150.1860.2999No
86SAT1NASAT1
Entrez,  Source
spermidine/spermine N1-acetyltransferase 170990.1740.2911No
87PPP3R1NAPPP3R1
Entrez,  Source
protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)72440.1640.2844No
88AVPR1ANAAVPR1A
Entrez,  Source
arginine vasopressin receptor 1A74230.1500.2757No
89AIFM3NA74280.1490.2766No
90CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)75230.1430.2725No
91IFNB1NAIFNB1
Entrez,  Source
interferon, beta 1, fibroblast77180.1290.2627No
92LGALS3NALGALS3
Entrez,  Source
lectin, galactoside-binding, soluble, 3 (galectin 3)79580.1110.2503No
93RHOT2NARHOT2
Entrez,  Source
ras homolog gene family, member T280470.1040.2463No
94BCL2L10NABCL2L10
Entrez,  Source
BCL2-like 10 (apoptosis facilitator)80890.1000.2448No
95HGFNAHGF
Entrez,  Source
hepatocyte growth factor (hepapoietin A; scatter factor)81930.0930.2398No
96ROCK1NAROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 187430.0550.2097No
97ENO2NAENO2
Entrez,  Source
enolase 2 (gamma, neuronal)89990.0350.1958No
98SPTAN1NASPTAN1
Entrez,  Source
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)91420.0240.1881No
99EMP1NAEMP1
Entrez,  Source
epithelial membrane protein 192560.0160.1820No
100GUCY2DNAGUCY2D
Entrez,  Source
guanylate cyclase 2D, membrane (retina-specific)93470.0110.1771No
101DAP3NADAP3
Entrez,  Source
death associated protein 393630.0100.1763No
102BCL2L2NABCL2L2
Entrez,  Source
BCL2-like 29756-0.0030.1546No
103CCND2NACCND2
Entrez,  Source
cyclin D210056-0.0230.1382No
104FDXRNAFDXR
Entrez,  Source
ferredoxin reductase10185-0.0300.1313No
105XIAPNA10443-0.0450.1174No
106PRF1NAPRF1
Entrez,  Source
perforin 1 (pore forming protein)10618-0.0550.1082No
107GSTM1NAGSTM1
Entrez,  Source
glutathione S-transferase M110630-0.0560.1080No
108GSRNAGSR
Entrez,  Source
glutathione reductase10665-0.0590.1066No
109CFLARNACFLAR
Entrez,  Source
CASP8 and FADD-like apoptosis regulator10825-0.0670.0982No
110ADD1NAADD1
Entrez,  Source
adducin 1 (alpha)11353-0.1020.0698No
111BIDNABID
Entrez,  Source
BH3 interacting domain death agonist11556-0.1190.0595No
112PTK2NAPTK2
Entrez,  Source
PTK2 protein tyrosine kinase 211849-0.1440.0444No
113PLCB2NAPLCB2
Entrez,  Source
phospholipase C, beta 211908-0.1480.0423No
114GADD45BNAGADD45B
Entrez,  Source
growth arrest and DNA-damage-inducible, beta11970-0.1530.0402No
115SMAD7NASMAD7
Entrez,  Source
SMAD, mothers against DPP homolog 7 (Drosophila)12163-0.1700.0308No
116ETF1NAETF1
Entrez,  Source
eukaryotic translation termination factor 112340-0.1860.0225No
117EBPNAEBP
Entrez,  Source
emopamil binding protein (sterol isomerase)12468-0.1980.0170No
118BGNNABGN
Entrez,  Source
biglycan12475-0.1990.0182No
119RHOBNARHOB
Entrez,  Source
ras homolog gene family, member B12525-0.2040.0171No
120CTNNB1NACTNNB1
Entrez,  Source
catenin (cadherin-associated protein), beta 1, 88kDa12660-0.2160.0114No
121IER3NAIER3
Entrez,  Source
immediate early response 313360-0.277-0.0253No
122IGF2RNAIGF2R
Entrez,  Source
insulin-like growth factor 2 receptor13479-0.290-0.0296No
123FASLGNAFASLG
Entrez,  Source
Fas ligand (TNF superfamily, member 6)13862-0.326-0.0482No
124SOD1NASOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))13992-0.344-0.0527No
125CAV1NACAV1
Entrez,  Source
caveolin 1, caveolae protein, 22kDa13996-0.345-0.0502No
126VDAC2NAVDAC2
Entrez,  Source
voltage-dependent anion channel 214442-0.398-0.0718No
127F2RNAF2R
Entrez,  Source
coagulation factor II (thrombin) receptor14494-0.404-0.0714No
128CD69NACD69
Entrez,  Source
CD69 molecule14577-0.416-0.0727No
129CDK2NACDK2
Entrez,  Source
cyclin-dependent kinase 214672-0.427-0.0746No
130BTG3NABTG3
Entrez,  Source
BTG family, member 314860-0.457-0.0814No
131F2NAF2
Entrez,  Source
coagulation factor II (thrombin)14879-0.459-0.0788No
132TXNIPNATXNIP
Entrez,  Source
thioredoxin interacting protein14955-0.469-0.0793No
133GSNNAGSN
Entrez,  Source
gelsolin (amyloidosis, Finnish type)15393-0.531-0.0994No
134FEZ1NAFEZ1
Entrez,  Source
fasciculation and elongation protein zeta 1 (zygin I)15442-0.540-0.0979No
135NEFHNANEFH
Entrez,  Source
neurofilament, heavy polypeptide 200kDa15853-0.622-0.1158No
136DPYDNADPYD
Entrez,  Source
dihydropyrimidine dehydrogenase15908-0.634-0.1138No
137PPT1NAPPT1
Entrez,  Source
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)16196-0.705-0.1242No
138TOP2ANATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa16265-0.724-0.1223No
139GPX4NAGPX4
Entrez,  Source
glutathione peroxidase 4 (phospholipid hydroperoxidase)16319-0.740-0.1195No
140BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 216401-0.765-0.1180No
141SATB1NASATB1
Entrez,  Source
special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's)16579-0.821-0.1214No
142TIMP2NATIMP2
Entrez,  Source
TIMP metallopeptidase inhibitor 216590-0.824-0.1155No
143CDKN1BNACDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)16862-0.909-0.1234No
144ERBB3NAERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)16960-0.952-0.1214No
145HMGB2NAHMGB2
Entrez,  Source
high-mobility group box 216990-0.964-0.1154No
146CD2NACD2
Entrez,  Source
CD2 molecule17032-0.986-0.1100No
147CTHNACTH
Entrez,  Source
cystathionase (cystathionine gamma-lyase)17134-1.027-0.1076No
148EGR3NAEGR3
Entrez,  Source
early growth response 317235-1.079-0.1047No
149CASP9NACASP9
Entrez,  Source
caspase 9, apoptosis-related cysteine peptidase17671-1.437-0.1176No
150PDCD4NAPDCD4
Entrez,  Source
programmed cell death 4 (neoplastic transformation inhibitor)17740-1.515-0.1095No
151ANKHNAANKH
Entrez,  Source
ankylosis, progressive homolog (mouse)17759-1.546-0.0984No
152BNIP3LNABNIP3L
Entrez,  Source
BCL2/adenovirus E1B 19kDa interacting protein 3-like17802-1.619-0.0881No
153PDGFRBNAPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide17904-1.866-0.0791No
154LUMNALUM
Entrez,  Source
lumican17955-2.047-0.0659No
155BTG2NABTG2
Entrez,  Source
BTG family, member 217959-2.061-0.0499No
156DCNNADCN
Entrez,  Source
decorin18141-3.763-0.0305No
157BMFNABMF
Entrez,  Source
Bcl2 modifying factor18151-4.0800.0009No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_APOPTOSIS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_APOPTOSIS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_APOPTOSIS