Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_APICAL_JUNCTION
Enrichment Score (ES)0.3889004
Normalized Enrichment Score (NES)1.5500548
Nominal p-value0.0030075188
FDR q-value0.014409977
FWER p-Value0.15
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_APICAL_JUNCTION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1COL17A1NACOL17A1
Entrez,  Source
collagen, type XVII, alpha 1374.3470.0334Yes
2CLDN4NACLDN4
Entrez,  Source
claudin 4723.6390.0611Yes
3TRAF1NATRAF1
Entrez,  Source
TNF receptor-associated factor 1893.3230.0873Yes
4TNFRSF11BNATNFRSF11B
Entrez,  Source
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)1222.9650.1097Yes
5ITGA2NAITGA2
Entrez,  Source
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)1482.7200.1305Yes
6CDH3NACDH3
Entrez,  Source
cadherin 3, type 1, P-cadherin (placental)2492.1780.1427Yes
7CD276NACD276
Entrez,  Source
CD276 molecule2502.1780.1604Yes
8ICAM2NAICAM2
Entrez,  Source
intercellular adhesion molecule 22832.0500.1754Yes
9COL16A1NACOL16A1
Entrez,  Source
collagen, type XVI, alpha 13321.8840.1880Yes
10ITGA10NAITGA10
Entrez,  Source
integrin, alpha 103331.8760.2033Yes
11LAMB3NALAMB3
Entrez,  Source
laminin, beta 33431.8460.2179Yes
12ICAM1NAICAM1
Entrez,  Source
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor4531.6000.2249Yes
13ITGB4NAITGB4
Entrez,  Source
integrin, beta 44791.5720.2363Yes
14ZYXNAZYX
Entrez,  Source
zyxin5381.5010.2453Yes
15CD34NACD34
Entrez,  Source
CD34 molecule5621.4710.2560Yes
16VWFNAVWF
Entrez,  Source
von Willebrand factor6891.3320.2598Yes
17CDH8NACDH8
Entrez,  Source
cadherin 8, type 27631.2740.2662Yes
18STX4NASTX4
Entrez,  Source
syntaxin 48071.2430.2739Yes
19ACTG1NAACTG1
Entrez,  Source
actin, gamma 18871.1810.2791Yes
20SRCNASRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)9011.1760.2880Yes
21RHOFNARHOF
Entrez,  Source
ras homolog gene family, member F (in filopodia)9051.1710.2974Yes
22LAMC2NALAMC2
Entrez,  Source
laminin, gamma 29171.1600.3062Yes
23ITGA3NAITGA3
Entrez,  Source
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)9611.1380.3131Yes
24EGFRNAEGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)10421.0980.3176Yes
25CDSNNACDSN
Entrez,  Source
corneodesmosin11681.0360.3191Yes
26CERCAMNA11891.0270.3263Yes
27TAOK2NATAOK2
Entrez,  Source
TAO kinase 211961.0240.3343Yes
28SPEGNASPEG
Entrez,  Source
SPEG complex locus13820.9520.3318Yes
29PKD1NAPKD1
Entrez,  Source
polycystic kidney disease 1 (autosomal dominant)14530.9270.3355Yes
30SORBS3NASORBS3
Entrez,  Source
sorbin and SH3 domain containing 315390.8990.3381Yes
31IKBKGNAIKBKG
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma15870.8840.3427Yes
32WNK4NAWNK4
Entrez,  Source
WNK lysine deficient protein kinase 416150.8760.3483Yes
33BAIAP2NABAIAP2
Entrez,  Source
BAI1-associated protein 216300.8730.3546Yes
34RAC2NARAC2
Entrez,  Source
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)17480.8390.3550Yes
35ACTN1NAACTN1
Entrez,  Source
actinin, alpha 117550.8380.3614Yes
36ACTBNAACTB
Entrez,  Source
actin, beta17650.8360.3678Yes
37HRASNAHRAS
Entrez,  Source
v-Ha-ras Harvey rat sarcoma viral oncogene homolog17990.8310.3727Yes
38SYKNASYK
Entrez,  Source
spleen tyrosine kinase19340.8020.3718Yes
39ACTN4NAACTN4
Entrez,  Source
actinin, alpha 423210.7190.3562Yes
40TUBG1NATUBG1
Entrez,  Source
tubulin, gamma 123550.7110.3601Yes
41VAV2NAVAV2
Entrez,  Source
vav 2 oncogene23820.7060.3644Yes
42PFN1NAPFN1
Entrez,  Source
profilin 124040.7020.3690Yes
43MYH9NAMYH9
Entrez,  Source
myosin, heavy chain 9, non-muscle24670.6910.3712Yes
44GRB7NAGRB7
Entrez,  Source
growth factor receptor-bound protein 724820.6880.3760Yes
45ARHGEF6NAARHGEF6
Entrez,  Source
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 625050.6840.3803Yes
46CX3CL1NACX3CL1
Entrez,  Source
chemokine (C-X3-C motif) ligand 125260.6810.3848Yes
47MSNNAMSN
Entrez,  Source
moesin25570.6750.3886Yes
48GTF2F1NAGTF2F1
Entrez,  Source
general transcription factor IIF, polypeptide 1, 74kDa26490.6570.3889Yes
49MPZL1NAMPZL1
Entrez,  Source
myelin protein zero-like 129530.6030.3770No
50FBN1NAFBN1
Entrez,  Source
fibrillin 130820.5840.3746No
51PPP2R2CNAPPP2R2C
Entrez,  Source
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform31700.5710.3744No
52PBX2NAPBX2
Entrez,  Source
pre-B-cell leukemia transcription factor 233680.5410.3679No
53PCDH1NAPCDH1
Entrez,  Source
protocadherin 1 (cadherin-like 1)34110.5350.3699No
54NRAPNANRAP
Entrez,  Source
nebulin-related anchoring protein34740.5250.3707No
55MPZL2NA34810.5240.3747No
56DHX16NADHX16
Entrez,  Source
DEAH (Asp-Glu-Ala-His) box polypeptide 1637250.4940.3652No
57VASPNAVASP
Entrez,  Source
vasodilator-stimulated phosphoprotein38730.4780.3609No
58SHC1NASHC1
Entrez,  Source
SHC (Src homology 2 domain containing) transforming protein 140000.4620.3576No
59PECAM1NAPECAM1
Entrez,  Source
platelet/endothelial cell adhesion molecule (CD31 antigen)40610.4540.3580No
60VCLNAVCL
Entrez,  Source
vinculin40900.4480.3601No
61FLNCNAFLNC
Entrez,  Source
filamin C, gamma (actin binding protein 280)41320.4420.3614No
62TSPAN4NATSPAN4
Entrez,  Source
tetraspanin 442010.4340.3612No
63PTPRCNAPTPRC
Entrez,  Source
protein tyrosine phosphatase, receptor type, C42190.4320.3637No
64CNN2NACNN2
Entrez,  Source
calponin 242650.4260.3647No
65DMP1NADMP1
Entrez,  Source
dentin matrix acidic phosphoprotein43340.4180.3643No
66MAPK11NAMAPK11
Entrez,  Source
mitogen-activated protein kinase 1143420.4170.3673No
67SYMPKNASYMPK
Entrez,  Source
symplekin44990.4010.3619No
68IRS1NAIRS1
Entrez,  Source
insulin receptor substrate 145990.3930.3596No
69PDZD3NAPDZD3
Entrez,  Source
PDZ domain containing 346630.3860.3593No
70CD274NACD274
Entrez,  Source
CD274 molecule46650.3860.3624No
71FSCN1NAFSCN1
Entrez,  Source
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)46700.3860.3653No
72TRONATRO
Entrez,  Source
trophinin47270.3800.3653No
73AMIGO1NAAMIGO1
Entrez,  Source
adhesion molecule with Ig-like domain 147280.3790.3684No
74INPPL1NAINPPL1
Entrez,  Source
inositol polyphosphate phosphatase-like 150420.3470.3538No
75PIK3R3NAPIK3R3
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)51620.3350.3499No
76CLDN19NACLDN19
Entrez,  Source
claudin 1954690.3060.3354No
77SLIT2NASLIT2
Entrez,  Source
slit homolog 2 (Drosophila)61350.2510.3004No
78AKT2NAAKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 261440.2500.3020No
79CRB3NACRB3
Entrez,  Source
crumbs homolog 3 (Drosophila)61570.2500.3034No
80CDH15NACDH15
Entrez,  Source
cadherin 15, M-cadherin (myotubule)63240.2350.2960No
81CLDN9NACLDN9
Entrez,  Source
claudin 963260.2340.2979No
82LDLRAP1NALDLRAP1
Entrez,  Source
low density lipoprotein receptor adaptor protein 164880.2220.2907No
83RSU1NARSU1
Entrez,  Source
Ras suppressor protein 165060.2200.2916No
84TIAL1NATIAL1
Entrez,  Source
TIA1 cytotoxic granule-associated RNA binding protein-like 165750.2130.2896No
85YWHAHNAYWHAH
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide65800.2130.2911No
86MMP2NAMMP2
Entrez,  Source
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)66020.2120.2916No
87CDK8NACDK8
Entrez,  Source
cyclin-dependent kinase 866290.2090.2919No
88CLDN18NACLDN18
Entrez,  Source
claudin 1867750.1980.2854No
89TJP1NATJP1
Entrez,  Source
tight junction protein 1 (zona occludens 1)69820.1810.2754No
90TSC1NATSC1
Entrez,  Source
tuberous sclerosis 170320.1780.2742No
91JUPNAJUP
Entrez,  Source
junction plakoglobin70790.1750.2730No
92CLDN14NACLDN14
Entrez,  Source
claudin 1471650.1690.2697No
93CADM3NA73770.1530.2592No
94DSC1NADSC1
Entrez,  Source
desmocollin 176030.1360.2478No
95NF2NANF2
Entrez,  Source
neurofibromin 2 (bilateral acoustic neuroma)77350.1280.2415No
96ICAM4NAICAM4
Entrez,  Source
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)79020.1150.2332No
97RASA1NARASA1
Entrez,  Source
RAS p21 protein activator (GTPase activating protein) 179150.1140.2335No
98CAP1NACAP1
Entrez,  Source
CAP, adenylate cyclase-associated protein 1 (yeast)80080.1060.2292No
99NLGN2NANLGN2
Entrez,  Source
neuroligin 281020.0990.2249No
100MADCAM1NAMADCAM1
Entrez,  Source
mucosal vascular addressin cell adhesion molecule 181700.0950.2219No
101MAP4K2NAMAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 282050.0930.2208No
102CTNND1NACTNND1
Entrez,  Source
catenin (cadherin-associated protein), delta 182320.0910.2201No
103CLDN15NACLDN15
Entrez,  Source
claudin 1584140.0780.2106No
104ADAM15NAADAM15
Entrez,  Source
ADAM metallopeptidase domain 15 (metargidin)85530.0680.2035No
105MAPK14NAMAPK14
Entrez,  Source
mitogen-activated protein kinase 1488780.0450.1859No
106EVLNAEVL
Entrez,  Source
Enah/Vasp-like89110.0430.1844No
107NF1NANF1
Entrez,  Source
neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)89240.0420.1841No
108VCANNA89800.0360.1813No
109ADRA1BNAADRA1B
Entrez,  Source
adrenergic, alpha-1B-, receptor92760.0150.1650No
110CLDN11NACLDN11
Entrez,  Source
claudin 11 (oligodendrocyte transmembrane protein)93070.0130.1635No
111ACTA1NAACTA1
Entrez,  Source
actin, alpha 1, skeletal muscle94200.0050.1573No
112KRT31NAKRT31
Entrez,  Source
keratin 3196960.0000.1420No
113CD99NACD99
Entrez,  Source
CD99 molecule10071-0.0230.1214No
114GNAI2NAGNAI2
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 210093-0.0250.1204No
115ACTG2NAACTG2
Entrez,  Source
actin, gamma 2, smooth muscle, enteric10102-0.0260.1202No
116ITGA9NAITGA9
Entrez,  Source
integrin, alpha 910122-0.0270.1193No
117NLGN3NANLGN3
Entrez,  Source
neuroligin 310329-0.0390.1082No
118EPB41L2NAEPB41L2
Entrez,  Source
erythrocyte membrane protein band 4.1-like 210414-0.0430.1039No
119PARVANAPARVA
Entrez,  Source
parvin, alpha10887-0.0700.0782No
120PLCG1NAPLCG1
Entrez,  Source
phospholipase C, gamma 110890-0.0710.0787No
121CDH4NACDH4
Entrez,  Source
cadherin 4, type 1, R-cadherin (retinal)10985-0.0770.0740No
122RRASNARRAS
Entrez,  Source
related RAS viral (r-ras) oncogene homolog11114-0.0850.0676No
123SGCENASGCE
Entrez,  Source
sarcoglycan, epsilon11231-0.0930.0619No
124ACTN3NAACTN3
Entrez,  Source
actinin, alpha 311241-0.0940.0622No
125MPP5NAMPP5
Entrez,  Source
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)11380-0.1040.0554No
126WASLNAWASL
Entrez,  Source
Wiskott-Aldrich syndrome-like11581-0.1210.0452No
127CLDN8NACLDN8
Entrez,  Source
claudin 811647-0.1270.0426No
128PIK3CBNAPIK3CB
Entrez,  Source
phosphoinositide-3-kinase, catalytic, beta polypeptide11650-0.1270.0436No
129B4GALT1NAB4GALT1
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 111658-0.1280.0442No
130AMIGO2NAAMIGO2
Entrez,  Source
adhesion molecule with Ig-like domain 211776-0.1370.0388No
131PTK2NAPTK2
Entrez,  Source
PTK2 protein tyrosine kinase 211849-0.1440.0360No
132LIMA1NALIMA1
Entrez,  Source
LIM domain and actin binding 112048-0.1600.0263No
133NRTNNANRTN
Entrez,  Source
neurturin12053-0.1600.0274No
134PTENNAPTEN
Entrez,  Source
phosphatase and tensin homolog (mutated in multiple advanced cancers 1)12081-0.1620.0272No
135CDH1NACDH1
Entrez,  Source
cadherin 1, type 1, E-cadherin (epithelial)12145-0.1680.0250No
136NFASCNANFASC
Entrez,  Source
neurofascin homolog (chicken)12185-0.1720.0243No
137ARPC2NAARPC2
Entrez,  Source
actin related protein 2/3 complex, subunit 2, 34kDa12205-0.1730.0246No
138DSC3NADSC3
Entrez,  Source
desmocollin 312228-0.1760.0248No
139SKAP2NASKAP2
Entrez,  Source
src kinase associated phosphoprotein 212421-0.1940.0157No
140GAMTNAGAMT
Entrez,  Source
guanidinoacetate N-methyltransferase12440-0.1960.0163No
141CLDN6NACLDN6
Entrez,  Source
claudin 612576-0.2080.0105No
142SLC30A3NASLC30A3
Entrez,  Source
solute carrier family 30 (zinc transporter), member 312584-0.2090.0118No
143NRXN2NANRXN2
Entrez,  Source
neurexin 212760-0.2240.0039No
144MYL12BNA12935-0.238-0.0038No
145MMP9NAMMP9
Entrez,  Source
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)13001-0.245-0.0054No
146KCNH2NAKCNH2
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 213020-0.246-0.0044No
147TMEM8BNA13079-0.251-0.0056No
148CTNNA1NACTNNA1
Entrez,  Source
catenin (cadherin-associated protein), alpha 1, 102kDa13267-0.269-0.0138No
149CD86NACD86
Entrez,  Source
CD86 molecule13386-0.280-0.0181No
150SHROOM2NASHROOM2
Entrez,  Source
shroom family member 213451-0.288-0.0193No
151COL9A1NACOL9A1
Entrez,  Source
collagen, type IX, alpha 113554-0.296-0.0226No
152CALB2NACALB2
Entrez,  Source
calbindin 2, 29kDa (calretinin)13671-0.309-0.0265No
153GNAI1NAGNAI1
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 114113-0.358-0.0481No
154BMP1NABMP1
Entrez,  Source
bone morphogenetic protein 114153-0.364-0.0473No
155NEXNNANEXN
Entrez,  Source
nexilin (F actin binding protein)14157-0.364-0.0445No
156LAYNNALAYN
Entrez,  Source
layilin14207-0.368-0.0443No
157MYL9NAMYL9
Entrez,  Source
myosin, light chain 9, regulatory14544-0.412-0.0596No
158HADHNAHADH
Entrez,  Source
hydroxyacyl-Coenzyme A dehydrogenase14585-0.417-0.0584No
159CDH6NACDH6
Entrez,  Source
cadherin 6, type 2, K-cadherin (fetal kidney)14747-0.436-0.0638No
160MVDNAMVD
Entrez,  Source
mevalonate (diphospho) decarboxylase14816-0.449-0.0640No
161CD209NACD209
Entrez,  Source
CD209 molecule14830-0.452-0.0610No
162MAPK13NAMAPK13
Entrez,  Source
mitogen-activated protein kinase 1314840-0.454-0.0578No
163CRATNACRAT
Entrez,  Source
carnitine acetyltransferase14842-0.454-0.0542No
164ALOX15BNAALOX15B
Entrez,  Source
arachidonate 15-lipoxygenase, type B14956-0.469-0.0566No
165MDKNAMDK
Entrez,  Source
midkine (neurite growth-promoting factor 2)14987-0.473-0.0544No
166CADM2NA15015-0.477-0.0521No
167PARD6GNAPARD6G
Entrez,  Source
par-6 partitioning defective 6 homolog gamma (C. elegans)15039-0.481-0.0494No
168CLDN5NACLDN5
Entrez,  Source
claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)15336-0.521-0.0616No
169VCAM1NAVCAM1
Entrez,  Source
vascular cell adhesion molecule 115433-0.538-0.0626No
170THY1NATHY1
Entrez,  Source
Thy-1 cell surface antigen15540-0.559-0.0639No
171ACTN2NAACTN2
Entrez,  Source
actinin, alpha 215627-0.577-0.0640No
172CDH11NACDH11
Entrez,  Source
cadherin 11, type 2, OB-cadherin (osteoblast)15656-0.582-0.0608No
173JAM3NAJAM3
Entrez,  Source
junctional adhesion molecule 315734-0.595-0.0603No
174AMHNAAMH
Entrez,  Source
anti-Mullerian hormone15881-0.630-0.0633No
175ADAMTS5NAADAMTS5
Entrez,  Source
ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)15967-0.647-0.0627No
176THBS3NATHBS3
Entrez,  Source
thrombospondin 316137-0.689-0.0665No
177EXOC4NAEXOC4
Entrez,  Source
exocyst complex component 416314-0.738-0.0703No
178ICAM5NAICAM5
Entrez,  Source
intercellular adhesion molecule 5, telencephalin16435-0.774-0.0706No
179ADAM23NAADAM23
Entrez,  Source
ADAM metallopeptidase domain 2316462-0.784-0.0657No
180DLG1NADLG1
Entrez,  Source
discs, large homolog 1 (Drosophila)16683-0.848-0.0710No
181SDC3NASDC3
Entrez,  Source
syndecan 3 (N-syndecan)16691-0.851-0.0645No
182MYH10NAMYH10
Entrez,  Source
myosin, heavy chain 10, non-muscle16776-0.879-0.0620No
183ADAM9NAADAM9
Entrez,  Source
ADAM metallopeptidase domain 9 (meltrin gamma)16903-0.928-0.0614No
184ITGB1NAITGB1
Entrez,  Source
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)16942-0.944-0.0559No
185LAMA3NALAMA3
Entrez,  Source
laminin, alpha 316986-0.962-0.0504No
186SIRPANASIRPA
Entrez,  Source
signal-regulatory protein alpha17393-1.183-0.0633No
187NEGR1NANEGR1
Entrez,  Source
neuronal growth regulator 117428-1.205-0.0554No
188INSIG1NAINSIG1
Entrez,  Source
insulin induced gene 117447-1.215-0.0465No
189ATP1A3NAATP1A3
Entrez,  Source
ATPase, Na+/K+ transporting, alpha 3 polypeptide17617-1.370-0.0448No
190AKT3NAAKT3
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)17766-1.559-0.0403No
191CNTN1NACNTN1
Entrez,  Source
contactin 117870-1.775-0.0315No
192ACTC1NAACTC1
Entrez,  Source
actin, alpha, cardiac muscle 117885-1.811-0.0176No
193TGFBINATGFBI
Entrez,  Source
transforming growth factor, beta-induced, 68kDa17950-2.031-0.0046No
194CLDN7NACLDN7
Entrez,  Source
claudin 717954-2.0350.0119No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_APICAL_JUNCTION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_APICAL_JUNCTION: Random ES distribution   
Gene set null distribution of ES for HALLMARK_APICAL_JUNCTION