Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_ALLOGRAFT_REJECTION
Enrichment Score (ES)0.41764998
Normalized Enrichment Score (NES)1.6742249
Nominal p-value0.0
FDR q-value0.005304918
FWER p-Value0.042
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_ALLOGRAFT_REJECTION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CCL5NACCL5
Entrez,  Source
chemokine (C-C motif) ligand 564.7680.0390Yes
2IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)174.5960.0763Yes
3WARSNAWARS
Entrez,  Source
tryptophanyl-tRNA synthetase494.1080.1084Yes
4IL2RGNAIL2RG
Entrez,  Source
interleukin 2 receptor, gamma (severe combined immunodeficiency)573.9550.1406Yes
5CTSSNACTSS
Entrez,  Source
cathepsin S1213.0030.1619Yes
6IL12RB1NAIL12RB1
Entrez,  Source
interleukin 12 receptor, beta 11782.5090.1795Yes
7TLR3NATLR3
Entrez,  Source
toll-like receptor 31902.4430.1990Yes
8JAK2NAJAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)3061.9580.2087Yes
9TAP1NATAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)3151.9210.2241Yes
10FLNANAFLNA
Entrez,  Source
filamin A, alpha (actin binding protein 280)4101.6950.2328Yes
11IL27RANAIL27RA
Entrez,  Source
interleukin 27 receptor, alpha4141.6850.2466Yes
12ICAM1NAICAM1
Entrez,  Source
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor4531.6000.2576Yes
13PSMB10NAPSMB10
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 104801.5690.2691Yes
14CCL2NACCL2
Entrez,  Source
chemokine (C-C motif) ligand 24931.5460.2812Yes
15IL4RNAIL4R
Entrez,  Source
interleukin 4 receptor5471.4860.2905Yes
16EREGNAEREG
Entrez,  Source
epiregulin5531.4790.3024Yes
17TGFB2NATGFB2
Entrez,  Source
transforming growth factor, beta 25891.4290.3123Yes
18TGFB1NATGFB1
Entrez,  Source
transforming growth factor, beta 1 (Camurati-Engelmann disease)5931.4250.3238Yes
19TAPBPNATAPBP
Entrez,  Source
TAP binding protein (tapasin)7171.3130.3278Yes
20IL1BNAIL1B
Entrez,  Source
interleukin 1, beta7791.2620.3348Yes
21IL7NAIL7
Entrez,  Source
interleukin 78571.2050.3405Yes
22BCL10NABCL10
Entrez,  Source
B-cell CLL/lymphoma 1010351.0990.3397Yes
23EGFRNAEGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)10421.0980.3484Yes
24TNFNATNF
Entrez,  Source
tumor necrosis factor (TNF superfamily, member 2)12101.0150.3475Yes
25BCL3NABCL3
Entrez,  Source
B-cell CLL/lymphoma 313000.9820.3506Yes
26CCND3NACCND3
Entrez,  Source
cyclin D313470.9640.3560Yes
27CD79ANACD79A
Entrez,  Source
CD79a molecule, immunoglobulin-associated alpha14690.9200.3569Yes
28RARSNARARS
Entrez,  Source
arginyl-tRNA synthetase15350.9000.3607Yes
29FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)16000.8810.3644Yes
30IL12BNAIL12B
Entrez,  Source
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)16070.8800.3713Yes
31CSF1NACSF1
Entrez,  Source
colony stimulating factor 1 (macrophage)16080.8800.3785Yes
32HLA-GNAHLA-G
Entrez,  Source
HLA-G histocompatibility antigen, class I, G17860.8320.3755Yes
33HLA-ANAHLA-A
Entrez,  Source
major histocompatibility complex, class I, A18690.8150.3777Yes
34ICOSLGNAICOSLG
Entrez,  Source
inducible T-cell co-stimulator ligand19030.8080.3825Yes
35IL18NAIL18
Entrez,  Source
interleukin 18 (interferon-gamma-inducing factor)19110.8050.3888Yes
36HLA-ENAHLA-E
Entrez,  Source
major histocompatibility complex, class I, E19150.8050.3952Yes
37B2MNAB2M
Entrez,  Source
beta-2-microglobulin19170.8050.4018Yes
38CSKNACSK
Entrez,  Source
c-src tyrosine kinase19910.7900.4043Yes
39TAP2NATAP2
Entrez,  Source
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)20930.7680.4050Yes
40LIFNALIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)21410.7550.4086Yes
41CD47NACD47
Entrez,  Source
CD47 molecule21660.7510.4134Yes
42PRKCGNAPRKCG
Entrez,  Source
protein kinase C, gamma23510.7110.4091Yes
43SOCS1NASOCS1
Entrez,  Source
suppressor of cytokine signaling 124850.6860.4073Yes
44NCF4NANCF4
Entrez,  Source
neutrophil cytosolic factor 4, 40kDa25120.6820.4115Yes
45IL2RANAIL2RA
Entrez,  Source
interleukin 2 receptor, alpha26050.6650.4119Yes
46CCL22NACCL22
Entrez,  Source
chemokine (C-C motif) ligand 2227090.6480.4115Yes
47IL15NAIL15
Entrez,  Source
interleukin 1527740.6350.4131Yes
48STAT1NASTAT1
Entrez,  Source
signal transducer and activator of transcription 1, 91kDa28540.6220.4139Yes
49FGRNAFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog29500.6040.4136Yes
50IFNAR2NAIFNAR2
Entrez,  Source
interferon (alpha, beta and omega) receptor 231130.5800.4093Yes
51HLA-DOBNAHLA-DOB
Entrez,  Source
major histocompatibility complex, class II, DO beta31370.5770.4128Yes
52IFNGR1NAIFNGR1
Entrez,  Source
interferon gamma receptor 131510.5750.4168Yes
53TRAF2NATRAF2
Entrez,  Source
TNF receptor-associated factor 232210.5640.4176Yes
54ETS1NAETS1
Entrez,  Source
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)33600.5420.4144No
55CAPGNACAPG
Entrez,  Source
capping protein (actin filament), gelsolin-like34090.5350.4162No
56TIMP1NATIMP1
Entrez,  Source
TIMP metallopeptidase inhibitor 137970.4860.3987No
57CARTPTNACARTPT
Entrez,  Source
CART prepropeptide38080.4840.4021No
58INHBBNAINHBB
Entrez,  Source
inhibin, beta B (activin AB beta polypeptide)38380.4820.4044No
59TLR6NATLR6
Entrez,  Source
toll-like receptor 639570.4670.4017No
60DEGS1NADEGS1
Entrez,  Source
degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)40470.4550.4005No
61PTPRCNAPTPRC
Entrez,  Source
protein tyrosine phosphatase, receptor type, C42190.4320.3946No
62LYNNALYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog42440.4280.3968No
63UBE2D1NAUBE2D1
Entrez,  Source
ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)42770.4250.3985No
64ELF4NAELF4
Entrez,  Source
E74-like factor 4 (ets domain transcription factor)43130.4210.4000No
65GLMNNAGLMN
Entrez,  Source
glomulin, FKBP associated protein43230.4200.4030No
66IL11NAIL11
Entrez,  Source
interleukin 1144000.4110.4021No
67CCR5NACCR5
Entrez,  Source
chemokine (C-C motif) receptor 545200.4000.3988No
68LY86NALY86
Entrez,  Source
lymphocyte antigen 8646390.3880.3954No
69TLR2NATLR2
Entrez,  Source
toll-like receptor 246770.3850.3966No
70APBB1NAAPBB1
Entrez,  Source
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)49430.3560.3848No
71C2NAC2
Entrez,  Source
complement component 251390.3380.3767No
72MAP4K1NAMAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 151840.3330.3770No
73CD74NACD74
Entrez,  Source
CD74 molecule, major histocompatibility complex, class II invariant chain51870.3330.3796No
74DYRK3NADYRK3
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 353290.3200.3744No
75CD3ENACD3E
Entrez,  Source
CD3e molecule, epsilon (CD3-TCR complex)55310.3010.3657No
76CD40LGNACD40LG
Entrez,  Source
CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)55450.3000.3675No
77SOCS5NASOCS5
Entrez,  Source
suppressor of cytokine signaling 560310.2610.3426No
78MTIF2NAMTIF2
Entrez,  Source
mitochondrial translational initiation factor 261990.2450.3354No
79CCL11NACCL11
Entrez,  Source
chemokine (C-C motif) ligand 1163980.2280.3262No
80BRCA1NABRCA1
Entrez,  Source
breast cancer 1, early onset64750.2230.3238No
81EIF5ANAEIF5A
Entrez,  Source
eukaryotic translation initiation factor 5A65190.2190.3232No
82LCKNALCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase66350.2080.3186No
83CCR2NACCR2
Entrez,  Source
chemokine (C-C motif) receptor 266410.2070.3200No
84ABI1NAABI1
Entrez,  Source
abl-interactor 167390.2010.3163No
85RIPK2NARIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 268040.1960.3143No
86SIT1NASIT1
Entrez,  Source
signaling threshold regulating transmembrane adaptor 168690.1900.3123No
87HDAC9NAHDAC9
Entrez,  Source
histone deacetylase 969900.1810.3071No
88IFNGR2NAIFNGR2
Entrez,  Source
interferon gamma receptor 2 (interferon gamma transducer 1)71180.1720.3015No
89HIF1ANAHIF1A
Entrez,  Source
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)72120.1660.2977No
90KRT1NAKRT1
Entrez,  Source
keratin 1 (epidermolytic hyperkeratosis)72320.1650.2980No
91IL2NAIL2
Entrez,  Source
interleukin 272690.1620.2973No
92ACHENAACHE
Entrez,  Source
acetylcholinesterase (Yt blood group)73050.1590.2967No
93INHBANAINHBA
Entrez,  Source
inhibin, beta A (activin A, activin AB alpha polypeptide)73090.1590.2978No
94ACVR2ANAACVR2A
Entrez,  Source
activin A receptor, type IIA73650.1550.2960No
95STAT4NASTAT4
Entrez,  Source
signal transducer and activator of transcription 474240.1500.2940No
96IL13NAIL13
Entrez,  Source
interleukin 1377700.1250.2759No
97CXCL13NACXCL13
Entrez,  Source
chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)78490.1190.2725No
98NLRP3NA78670.1170.2725No
99CD8BNACD8B
Entrez,  Source
CD8b molecule78820.1170.2727No
100AKT1NAAKT1
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 179220.1130.2715No
101ELANENA81710.0950.2584No
102LTBNALTB
Entrez,  Source
lymphotoxin beta (TNF superfamily, member 3)81970.0930.2578No
103CCL7NACCL7
Entrez,  Source
chemokine (C-C motif) ligand 782110.0920.2579No
104PF4NAPF4
Entrez,  Source
platelet factor 4 (chemokine (C-X-C motif) ligand 4)82630.0890.2558No
105KLRD1NAKLRD1
Entrez,  Source
killer cell lectin-like receptor subfamily D, member 188510.0470.2235No
106TLR1NATLR1
Entrez,  Source
toll-like receptor 189720.0370.2171No
107RPS9NARPS9
Entrez,  Source
ribosomal protein S990060.0350.2156No
108CRTAMNACRTAM
Entrez,  Source
cytotoxic and regulatory T cell molecule90180.0340.2152No
109IRF7NAIRF7
Entrez,  Source
interferon regulatory factor 791070.0270.2106No
110CD28NACD28
Entrez,  Source
CD28 molecule92470.0170.2030No
111WASNAWAS
Entrez,  Source
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)93810.0090.1956No
112UBE2NNAUBE2N
Entrez,  Source
ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)94860.0020.1899No
113NCK1NANCK1
Entrez,  Source
NCK adaptor protein 195030.0000.1890No
114IL4NAIL4
Entrez,  Source
interleukin 495340.0000.1873No
115CD3DNACD3D
Entrez,  Source
CD3d molecule, delta (CD3-TCR complex)97100.0000.1776No
116GPR65NAGPR65
Entrez,  Source
G protein-coupled receptor 659725-0.0000.1768No
117CDKN2ANACDKN2A
Entrez,  Source
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)9855-0.0100.1697No
118GCNT1NAGCNT1
Entrez,  Source
glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)9958-0.0170.1642No
119CCND2NACCND2
Entrez,  Source
cyclin D210056-0.0230.1590No
120RPS19NARPS19
Entrez,  Source
ribosomal protein S1910226-0.0330.1498No
121TRAT1NATRAT1
Entrez,  Source
T cell receptor associated transmembrane adaptor 110320-0.0390.1450No
122HCLS1NAHCLS1
Entrez,  Source
hematopoietic cell-specific Lyn substrate 110470-0.0460.1371No
123CD1DNACD1D
Entrez,  Source
CD1d molecule10589-0.0530.1309No
124GALNT1NAGALNT1
Entrez,  Source
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)10612-0.0550.1302No
125PRF1NAPRF1
Entrez,  Source
perforin 1 (pore forming protein)10618-0.0550.1303No
126EIF3DNA10622-0.0550.1306No
127CXCL9NACXCL9
Entrez,  Source
chemokine (C-X-C motif) ligand 910624-0.0550.1310No
128IL12ANAIL12A
Entrez,  Source
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)10711-0.0610.1268No
129CD40NACD40
Entrez,  Source
CD40 molecule, TNF receptor superfamily member 510873-0.0700.1184No
130IKBKBNAIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta10944-0.0740.1151No
131NCR1NANCR1
Entrez,  Source
natural cytotoxicity triggering receptor 110956-0.0750.1151No
132EIF3JNA11199-0.0910.1024No
133LY75NALY75
Entrez,  Source
lymphocyte antigen 7511247-0.0940.1005No
134HLA-DQA1NAHLA-DQA1
Entrez,  Source
major histocompatibility complex, class II, DQ alpha 111431-0.1080.0913No
135CD3GNACD3G
Entrez,  Source
CD3g molecule, gamma (CD3-TCR complex)11473-0.1130.0899No
136SRGNNA11542-0.1180.0871No
137MRPL3NAMRPL3
Entrez,  Source
mitochondrial ribosomal protein L311614-0.1230.0842No
138CD8ANACD8A
Entrez,  Source
CD8a molecule11810-0.1410.0745No
139LCP2NALCP2
Entrez,  Source
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)11815-0.1410.0754No
140CD7NACD7
Entrez,  Source
CD7 molecule11872-0.1460.0735No
141ABCE1NAABCE1
Entrez,  Source
ATP-binding cassette, sub-family E (OABP), member 111919-0.1490.0722No
142TPD52NATPD52
Entrez,  Source
tumor protein D5211937-0.1500.0725No
143CD96NACD96
Entrez,  Source
CD96 molecule12023-0.1580.0690No
144DARSNADARS
Entrez,  Source
aspartyl-tRNA synthetase12044-0.1590.0692No
145FCGR2BNAFCGR2B
Entrez,  Source
Fc fragment of IgG, low affinity IIb, receptor (CD32)12103-0.1640.0674No
146IL2RBNAIL2RB
Entrez,  Source
interleukin 2 receptor, beta12478-0.1990.0482No
147NPM1NANPM1
Entrez,  Source
nucleophosmin (nucleolar phosphoprotein B23, numatrin)12872-0.2320.0282No
148NOS2NA12973-0.2430.0247No
149MMP9NAMMP9
Entrez,  Source
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)13001-0.2450.0252No
150RPL3LNARPL3L
Entrez,  Source
ribosomal protein L3-like13298-0.2720.0110No
151CD86NACD86
Entrez,  Source
CD86 molecule13386-0.2800.0084No
152CCL19NACCL19
Entrez,  Source
chemokine (C-C motif) ligand 1913652-0.307-0.0038No
153IGSF6NAIGSF6
Entrez,  Source
immunoglobulin superfamily, member 613690-0.310-0.0033No
154FASLGNAFASLG
Entrez,  Source
Fas ligand (TNF superfamily, member 6)13862-0.326-0.0101No
155SPI1NASPI1
Entrez,  Source
spleen focus forming virus (SFFV) proviral integration oncogene spi113887-0.329-0.0087No
156EIF3ANA13915-0.332-0.0075No
157MAP3K7NAMAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 714046-0.351-0.0118No
158CFPNACFP
Entrez,  Source
complement factor properdin14067-0.354-0.0100No
159CD247NACD247
Entrez,  Source
CD247 molecule14094-0.357-0.0085No
160IRF8NAIRF8
Entrez,  Source
interferon regulatory factor 814315-0.381-0.0176No
161EIF4G3NAEIF4G3
Entrez,  Source
eukaryotic translation initiation factor 4 gamma, 314458-0.400-0.0222No
162F2RNAF2R
Entrez,  Source
coagulation factor II (thrombin) receptor14494-0.404-0.0209No
163RPL9NARPL9
Entrez,  Source
ribosomal protein L914529-0.409-0.0194No
164ITKNAITK
Entrez,  Source
IL2-inducible T-cell kinase14581-0.416-0.0188No
165IFNGNAIFNG
Entrez,  Source
interferon, gamma14617-0.420-0.0173No
166CXCR3NACXCR3
Entrez,  Source
chemokine (C-X-C motif) receptor 314620-0.420-0.0139No
167NME1NANME1
Entrez,  Source
non-metastatic cells 1, protein (NM23A) expressed in14686-0.429-0.0140No
168IL18RAPNAIL18RAP
Entrez,  Source
interleukin 18 receptor accessory protein14782-0.443-0.0156No
169F2NAF2
Entrez,  Source
coagulation factor II (thrombin)14879-0.459-0.0172No
170BCAT1NABCAT1
Entrez,  Source
branched chain aminotransferase 1, cytosolic14948-0.468-0.0171No
171GZMANAGZMA
Entrez,  Source
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)14995-0.474-0.0158No
172HLA-DOANAHLA-DOA
Entrez,  Source
major histocompatibility complex, class II, DO alpha15257-0.511-0.0261No
173ZAP70NAZAP70
Entrez,  Source
zeta-chain (TCR) associated protein kinase 70kDa15272-0.513-0.0226No
174RPS3ANARPS3A
Entrez,  Source
ribosomal protein S3A15343-0.522-0.0222No
175ITGALNAITGAL
Entrez,  Source
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)15441-0.540-0.0232No
176PRKCBNA15489-0.550-0.0212No
177HLA-DMBNAHLA-DMB
Entrez,  Source
major histocompatibility complex, class II, DM beta15525-0.556-0.0186No
178THY1NATHY1
Entrez,  Source
Thy-1 cell surface antigen15540-0.559-0.0148No
179RPL39NARPL39
Entrez,  Source
ribosomal protein L3915542-0.559-0.0102No
180IL10NAIL10
Entrez,  Source
interleukin 1015556-0.562-0.0063No
181ST8SIA4NAST8SIA4
Entrez,  Source
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 415666-0.584-0.0076No
182MBL2NAMBL2
Entrez,  Source
mannose-binding lectin (protein C) 2, soluble (opsonic defect)15678-0.586-0.0033No
183AARSNAAARS
Entrez,  Source
alanyl-tRNA synthetase15849-0.621-0.0077No
184IRF4NAIRF4
Entrez,  Source
interferon regulatory factor 415869-0.627-0.0036No
185CD80NACD80
Entrez,  Source
CD80 molecule16598-0.825-0.0373No
186ITGB2NAITGB2
Entrez,  Source
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)16810-0.892-0.0417No
187CD2NACD2
Entrez,  Source
CD2 molecule17032-0.986-0.0458No
188PTPN6NAPTPN6
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 617170-1.045-0.0448No
189IL16NAIL16
Entrez,  Source
interleukin 16 (lymphocyte chemoattractant factor)17417-1.198-0.0487No
190CD4NACD4
Entrez,  Source
CD4 molecule17673-1.437-0.0510No
191STAB1NASTAB1
Entrez,  Source
stabilin 117747-1.533-0.0424No
192CCR1NACCR1
Entrez,  Source
chemokine (C-C motif) receptor 117913-1.895-0.0360No
193HLA-DMANAHLA-DMA
Entrez,  Source
major histocompatibility complex, class II, DM alpha18085-2.849-0.0220No
194GBP2NAGBP2
Entrez,  Source
guanylate binding protein 2, interferon-inducible18111-3.2180.0031No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_ALLOGRAFT_REJECTION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_ALLOGRAFT_REJECTION: Random ES distribution   
Gene set null distribution of ES for HALLMARK_ALLOGRAFT_REJECTION