Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_ADIPOGENESIS
Enrichment Score (ES)-0.33478463
Normalized Enrichment Score (NES)-1.402164
Nominal p-value0.008498584
FDR q-value0.078886025
FWER p-Value0.329
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_ADIPOGENESIS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1LAMA4NALAMA4
Entrez,  Source
laminin, alpha 41242.9380.0252No
2FZD4NAFZD4
Entrez,  Source
frizzled homolog 4 (Drosophila)4491.6100.0248No
3GPX3NAGPX3
Entrez,  Source
glutathione peroxidase 3 (plasma)6881.3320.0262No
4GADD45ANAGADD45A
Entrez,  Source
growth arrest and DNA-damage-inducible, alpha8281.2250.0318No
5SLC19A1NASLC19A1
Entrez,  Source
solute carrier family 19 (folate transporter), member 18791.1880.0420No
6SLC5A6NASLC5A6
Entrez,  Source
solute carrier family 5 (sodium-dependent vitamin transporter), member 69661.1360.0497No
7SLC1A5NASLC1A5
Entrez,  Source
solute carrier family 1 (neutral amino acid transporter), member 515370.9000.0278No
8PEMTNAPEMT
Entrez,  Source
phosphatidylethanolamine N-methyltransferase17230.8450.0268No
9COL4A1NACOL4A1
Entrez,  Source
collagen, type IV, alpha 118180.8250.0306No
10DHRS7BNADHRS7B
Entrez,  Source
dehydrogenase/reductase (SDR family) member 7B24640.6920.0023No
11UCK1NAUCK1
Entrez,  Source
uridine-cytidine kinase 125740.6710.0035No
12DHRS7NADHRS7
Entrez,  Source
dehydrogenase/reductase (SDR family) member 727430.6420.0012No
13RETSATNARETSAT
Entrez,  Source
retinol saturase (all-trans-retinol 13,14-reductase)28020.6300.0049No
14AGPAT3NAAGPAT3
Entrez,  Source
1-acylglycerol-3-phosphate O-acyltransferase 328980.6140.0063No
15ITIH5NAITIH5
Entrez,  Source
inter-alpha (globulin) inhibitor H530970.5820.0017No
16CHUKNACHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase31030.5820.0077No
17ANGPTL4NAANGPTL4
Entrez,  Source
angiopoietin-like 431270.5780.0128No
18IFNGR1NAIFNGR1
Entrez,  Source
interferon gamma receptor 131510.5750.0178No
19MYLKNAMYLK
Entrez,  Source
myosin, light chain kinase31710.5710.0230No
20NDUFB7NANDUFB7
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa32830.5540.0229No
21TANKNATANK
Entrez,  Source
TRAF family member-associated NFKB activator36300.5070.0092No
22ALDOANAALDOA
Entrez,  Source
aldolase A, fructose-bisphosphate36790.4990.0120No
23ARAFNAARAF
Entrez,  Source
v-raf murine sarcoma 3611 viral oncogene homolog38650.4790.0069No
24STAT5ANASTAT5A
Entrez,  Source
signal transducer and activator of transcription 5A38750.4780.0116No
25ELMOD3NA41820.437-0.0006No
26NKIRAS1NANKIRAS1
Entrez,  Source
NFKB inhibitor interacting Ras-like 142210.4320.0020No
27ESRRANAESRRA
Entrez,  Source
estrogen-related receptor alpha42820.4240.0033No
28UBCNAUBC
Entrez,  Source
ubiquitin C42940.4220.0073No
29PREBNAPREB
Entrez,  Source
prolactin regulatory element binding43630.4150.0081No
30PPARGNAPPARG
Entrez,  Source
peroxisome proliferative activated receptor, gamma44280.4080.0090No
31PQLC3NAPQLC3
Entrez,  Source
PQ loop repeat containing 346800.385-0.0008No
32PPM1BNAPPM1B
Entrez,  Source
protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform46990.3830.0024No
33DBTNADBT
Entrez,  Source
dihydrolipoamide branched chain transacylase E247240.3800.0052No
34PEX14NAPEX14
Entrez,  Source
peroxisomal biogenesis factor 1448160.3710.0042No
35RREB1NARREB1
Entrez,  Source
ras responsive element binding protein 148900.3630.0041No
36ABCB8NAABCB8
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 851940.332-0.0091No
37NMT1NANMT1
Entrez,  Source
N-myristoyltransferase 153360.319-0.0134No
38MAP4K3NAMAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 353870.314-0.0128No
39PFKFB3NAPFKFB3
Entrez,  Source
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 354260.310-0.0115No
40MRAPNAMRAP
Entrez,  Source
melanocortin 2 receptor accessory protein56600.291-0.0213No
41CMBLNACMBL
Entrez,  Source
carboxymethylenebutenolidase homolog (Pseudomonas)58490.274-0.0288No
42HSPB8NAHSPB8
Entrez,  Source
heat shock 22kDa protein 859680.265-0.0324No
43GPD2NAGPD2
Entrez,  Source
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)60060.263-0.0316No
44JAGN1NAJAGN1
Entrez,  Source
jagunal homolog 1 (Drosophila)60220.262-0.0296No
45ATL2NA61100.253-0.0317No
46ARL4ANAARL4A
Entrez,  Source
ADP-ribosylation factor-like 4A62800.238-0.0384No
47ENPP2NAENPP2
Entrez,  Source
ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)63000.236-0.0369No
48ADCY6NAADCY6
Entrez,  Source
adenylate cyclase 663430.234-0.0367No
49GPHNNAGPHN
Entrez,  Source
gephyrin63750.231-0.0359No
50ESYT1NA65000.221-0.0404No
51DNAJC15NADNAJC15
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily C, member 1565180.219-0.0389No
52TOB1NATOB1
Entrez,  Source
transducer of ERBB2, 166030.212-0.0413No
53LEPNALEP
Entrez,  Source
leptin (obesity homolog, mouse)66100.211-0.0393No
54ANGPT1NAANGPT1
Entrez,  Source
angiopoietin 166920.204-0.0416No
55IDH3GNAIDH3G
Entrez,  Source
isocitrate dehydrogenase 3 (NAD+) gamma67460.199-0.0424No
56CDKN2CNACDKN2C
Entrez,  Source
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)67940.197-0.0428No
57CSNACS
Entrez,  Source
citrate synthase68780.190-0.0454No
58LTC4SNALTC4S
Entrez,  Source
leukotriene C4 synthase69440.184-0.0470No
59BAZ2ANABAZ2A
Entrez,  Source
bromodomain adjacent to zinc finger domain, 2A70080.179-0.0485No
60RAB34NARAB34
Entrez,  Source
RAB34, member RAS oncogene family72270.165-0.0588No
61MRPL15NAMRPL15
Entrez,  Source
mitochondrial ribosomal protein L1574170.150-0.0677No
62UQCR11NA75110.144-0.0713No
63QDPRNAQDPR
Entrez,  Source
quinoid dihydropteridine reductase75380.142-0.0712No
64SPARCL1NASPARCL1
Entrez,  Source
SPARC-like 1 (mast9, hevin)76140.135-0.0739No
65ITSN1NAITSN1
Entrez,  Source
intersectin 1 (SH3 domain protein)77520.126-0.0801No
66TKTNATKT
Entrez,  Source
transketolase (Wernicke-Korsakoff syndrome)77860.124-0.0806No
67SORBS1NASORBS1
Entrez,  Source
sorbin and SH3 domain containing 179300.113-0.0873No
68AK2NAAK2
Entrez,  Source
adenylate kinase 281900.094-0.1007No
69DNAJB9NADNAJB9
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily B, member 982290.091-0.1018No
70ORM1NAORM1
Entrez,  Source
orosomucoid 182430.090-0.1016No
71UBQLN1NAUBQLN1
Entrez,  Source
ubiquilin 183330.083-0.1056No
72PHYHNAPHYH
Entrez,  Source
phytanoyl-CoA 2-hydroxylase83680.081-0.1066No
73PIM3NAPIM3
Entrez,  Source
pim-3 oncogene84400.076-0.1097No
74GBE1NAGBE1
Entrez,  Source
glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV)84520.075-0.1095No
75CPT2NACPT2
Entrez,  Source
carnitine palmitoyltransferase II86520.061-0.1199No
76LIFRNALIFR
Entrez,  Source
leukemia inhibitory factor receptor alpha89670.038-0.1370No
77BCL2L13NABCL2L13
Entrez,  Source
BCL2-like 13 (apoptosis facilitator)91950.021-0.1494No
78APOENAAPOE
Entrez,  Source
apolipoprotein E91960.021-0.1491No
79CYP4B1NACYP4B1
Entrez,  Source
cytochrome P450, family 4, subfamily B, polypeptide 193560.011-0.1579No
80CIDEANACIDEA
Entrez,  Source
cell death-inducing DFFA-like effector a96700.000-0.1753No
81OMDNAOMD
Entrez,  Source
osteomodulin9760-0.003-0.1802No
82FABP4NAFABP4
Entrez,  Source
fatty acid binding protein 4, adipocyte9789-0.005-0.1817No
83PHLDB1NAPHLDB1
Entrez,  Source
pleckstrin homology-like domain, family B, member 19792-0.005-0.1817No
84SAMM50NASAMM50
Entrez,  Source
sorting and assembly machinery component 50 homolog (S. cerevisiae)9802-0.006-0.1822No
85PGM1NAPGM1
Entrez,  Source
phosphoglucomutase 19960-0.017-0.1907No
86LIPENALIPE
Entrez,  Source
lipase, hormone-sensitive10196-0.031-0.2035No
87PPP1R15BNAPPP1R15B
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15B10265-0.036-0.2068No
88CD151NACD151
Entrez,  Source
CD151 molecule (Raph blood group)10301-0.039-0.2084No
89RTN3NARTN3
Entrez,  Source
reticulon 310330-0.040-0.2095No
90RNF11NARNF11
Entrez,  Source
ring finger protein 1110459-0.045-0.2161No
91RIOK3NARIOK3
Entrez,  Source
RIO kinase 3 (yeast)10627-0.056-0.2248No
92SSPNNASSPN
Entrez,  Source
sarcospan (Kras oncogene-associated gene)10648-0.057-0.2253No
93GRPEL1NAGRPEL1
Entrez,  Source
GrpE-like 1, mitochondrial (E. coli)10668-0.059-0.2257No
94DLATNADLAT
Entrez,  Source
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)11362-0.102-0.2631No
95BCL6NABCL6
Entrez,  Source
B-cell CLL/lymphoma 6 (zinc finger protein 51)11376-0.104-0.2627No
96TSTNATST
Entrez,  Source
thiosulfate sulfurtransferase (rhodanese)11432-0.109-0.2646No
97YWHAGNAYWHAG
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide11455-0.111-0.2646No
98SLC25A10NASLC25A10
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 1011765-0.136-0.2803No
99MDH2NAMDH2
Entrez,  Source
malate dehydrogenase 2, NAD (mitochondrial)11787-0.139-0.2799No
100CMPK1NA11921-0.149-0.2857No
101ACLYNAACLY
Entrez,  Source
ATP citrate lyase12137-0.168-0.2958No
102FAHNAFAH
Entrez,  Source
fumarylacetoacetate hydrolase (fumarylacetoacetase)12156-0.169-0.2950No
103ADIPOR2NAADIPOR2
Entrez,  Source
adiponectin receptor 212436-0.196-0.3083No
104DHCR7NADHCR7
Entrez,  Source
7-dehydrocholesterol reductase12472-0.198-0.3081No
105ME1NAME1
Entrez,  Source
malic enzyme 1, NADP(+)-dependent, cytosolic12526-0.204-0.3088No
106ACAA2NAACAA2
Entrez,  Source
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)12565-0.207-0.3087No
107APLP2NAAPLP2
Entrez,  Source
amyloid beta (A4) precursor-like protein 212604-0.210-0.3085No
108TALDO1NATALDO1
Entrez,  Source
transaldolase 112656-0.216-0.3090No
109MGLLNAMGLL
Entrez,  Source
monoglyceride lipase12767-0.225-0.3126No
110HIBCHNAHIBCH
Entrez,  Source
3-hydroxyisobutyryl-Coenzyme A hydrolase12823-0.228-0.3132No
111CYC1NACYC1
Entrez,  Source
cytochrome c-112899-0.235-0.3148No
112VEGFBNAVEGFB
Entrez,  Source
vascular endothelial growth factor B12945-0.240-0.3147No
113GHITMNAGHITM
Entrez,  Source
growth hormone inducible transmembrane protein12954-0.241-0.3125No
114IDH3ANAIDH3A
Entrez,  Source
isocitrate dehydrogenase 3 (NAD+) alpha12987-0.244-0.3116No
115DDTNADDT
Entrez,  Source
D-dopachrome tautomerase13235-0.266-0.3224No
116ETFBNAETFB
Entrez,  Source
electron-transfer-flavoprotein, beta polypeptide13238-0.266-0.3196No
117STOMNASTOM
Entrez,  Source
stomatin13438-0.286-0.3276No
118ECHS1NAECHS1
Entrez,  Source
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial13439-0.286-0.3245No
119COQ3NACOQ3
Entrez,  Source
coenzyme Q3 homolog, methyltransferase (S. cerevisiae)13452-0.288-0.3220No
120AIFM1NA13591-0.300-0.3264No
121SDHCNASDHC
Entrez,  Source
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa13605-0.301-0.3238No
122G3BP2NAG3BP2
Entrez,  Source
-13625-0.305-0.3215No
123UCP2NAUCP2
Entrez,  Source
uncoupling protein 2 (mitochondrial, proton carrier)13632-0.305-0.3185No
124BCKDHANABCKDHA
Entrez,  Source
branched chain keto acid dehydrogenase E1, alpha polypeptide13726-0.313-0.3203No
125EPHX2NAEPHX2
Entrez,  Source
epoxide hydrolase 2, cytoplasmic13870-0.327-0.3246No
126SOD1NASOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))13992-0.344-0.3276No
127UQCRC1NAUQCRC1
Entrez,  Source
ubiquinol-cytochrome c reductase core protein I14122-0.360-0.3309Yes
128SLC27A1NASLC27A1
Entrez,  Source
solute carrier family 27 (fatty acid transporter), member 114128-0.360-0.3272Yes
129ACO2NAACO2
Entrez,  Source
aconitase 2, mitochondrial14158-0.364-0.3248Yes
130DRAM2NA14195-0.367-0.3228Yes
131COX6A1NACOX6A1
Entrez,  Source
cytochrome c oxidase subunit VIa polypeptide 114365-0.387-0.3280Yes
132DGAT1NADGAT1
Entrez,  Source
diacylglycerol O-acyltransferase homolog 1 (mouse)14394-0.390-0.3253Yes
133REEP5NAREEP5
Entrez,  Source
receptor accessory protein 514400-0.391-0.3213Yes
134HADHNAHADH
Entrez,  Source
hydroxyacyl-Coenzyme A dehydrogenase14585-0.417-0.3269Yes
135PTCD3NAPTCD3
Entrez,  Source
Pentatricopeptide repeat domain 314615-0.420-0.3240Yes
136ACADSNAACADS
Entrez,  Source
acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain14739-0.435-0.3260Yes
137UQCRQNAUQCRQ
Entrez,  Source
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa14817-0.449-0.3254Yes
138CRATNACRAT
Entrez,  Source
carnitine acetyltransferase14842-0.454-0.3218Yes
139ACOX1NAACOX1
Entrez,  Source
acyl-Coenzyme A oxidase 1, palmitoyl14870-0.458-0.3183Yes
140ACADLNAACADL
Entrez,  Source
acyl-Coenzyme A dehydrogenase, long chain14880-0.459-0.3138Yes
141NDUFS3NANDUFS3
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)15047-0.482-0.3177Yes
142PFKLNAPFKL
Entrez,  Source
phosphofructokinase, liver15122-0.492-0.3165Yes
143ATP5ONAATP5O
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)15213-0.505-0.3159Yes
144SULT1A1NASULT1A1
Entrez,  Source
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 115215-0.505-0.3105Yes
145SCP2NASCP2
Entrez,  Source
sterol carrier protein 215228-0.506-0.3056Yes
146IDH1NAIDH1
Entrez,  Source
isocitrate dehydrogenase 1 (NADP+), soluble15361-0.527-0.3072Yes
147DLDNADLD
Entrez,  Source
dihydrolipoamide dehydrogenase15418-0.535-0.3045Yes
148COQ9NACOQ9
Entrez,  Source
coenzyme Q9 homolog (S. cerevisiae)15487-0.550-0.3022Yes
149PORNAPOR
Entrez,  Source
P450 (cytochrome) oxidoreductase15547-0.561-0.2994Yes
150REEP6NAREEP6
Entrez,  Source
receptor accessory protein 615569-0.566-0.2944Yes
151NDUFAB1NANDUFAB1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa15592-0.569-0.2894Yes
152SDHBNASDHB
Entrez,  Source
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)15593-0.569-0.2831Yes
153ATP1B3NAATP1B3
Entrez,  Source
ATPase, Na+/K+ transporting, beta 3 polypeptide15637-0.579-0.2792Yes
154IMMTNAIMMT
Entrez,  Source
inner membrane protein, mitochondrial (mitofilin)15645-0.581-0.2732Yes
155PLIN2NA15679-0.586-0.2687Yes
156CHCHD10NA15820-0.614-0.2697Yes
157SCARB1NASCARB1
Entrez,  Source
scavenger receptor class B, member 115938-0.640-0.2692Yes
158COX8ANACOX8A
Entrez,  Source
cytochrome c oxidase subunit 8A (ubiquitous)15949-0.642-0.2628Yes
159SLC25A1NASLC25A1
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 116054-0.669-0.2612Yes
160MTCH2NAMTCH2
Entrez,  Source
mitochondrial carrier homolog 2 (C. elegans)16127-0.687-0.2577Yes
161MCCC1NAMCCC1
Entrez,  Source
methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)16243-0.719-0.2563Yes
162PTGER3NAPTGER3
Entrez,  Source
prostaglandin E receptor 3 (subtype EP3)16248-0.720-0.2486Yes
163GPX4NAGPX4
Entrez,  Source
glutathione peroxidase 4 (phospholipid hydroperoxidase)16319-0.740-0.2444Yes
164ADIPOQNAADIPOQ
Entrez,  Source
adiponectin, C1Q and collagen domain containing16360-0.751-0.2384Yes
165C3NAC3
Entrez,  Source
complement component 316387-0.761-0.2316Yes
166LPCAT3NA16415-0.769-0.2247Yes
167UQCR10NA16475-0.787-0.2193Yes
168GPAMNAGPAM
Entrez,  Source
glycerol-3-phosphate acyltransferase, mitochondrial16497-0.797-0.2118Yes
169COQ5NACOQ5
Entrez,  Source
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)16595-0.825-0.2082Yes
170SUCLG1NASUCLG1
Entrez,  Source
succinate-CoA ligase, GDP-forming, alpha subunit16597-0.825-0.1992Yes
171ALDH2NAALDH2
Entrez,  Source
aldehyde dehydrogenase 2 family (mitochondrial)16658-0.842-0.1933Yes
172DECR1NADECR1
Entrez,  Source
2,4-dienoyl CoA reductase 1, mitochondrial16734-0.867-0.1880Yes
173ELOVL6NAELOVL6
Entrez,  Source
ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)16737-0.868-0.1786Yes
174PRDX3NAPRDX3
Entrez,  Source
peroxiredoxin 316863-0.909-0.1756Yes
175SNCGNASNCG
Entrez,  Source
synuclein, gamma (breast cancer-specific protein 1)16988-0.963-0.1720Yes
176CD36NACD36
Entrez,  Source
CD36 molecule (thrombospondin receptor)17086-1.007-0.1664Yes
177ITGA7NAITGA7
Entrez,  Source
integrin, alpha 717088-1.007-0.1554Yes
178ECH1NAECH1
Entrez,  Source
enoyl Coenzyme A hydratase 1, peroxisomal17135-1.027-0.1468Yes
179CATNACAT
Entrez,  Source
catalase17167-1.043-0.1371Yes
180COX7BNACOX7B
Entrez,  Source
cytochrome c oxidase subunit VIIb17181-1.049-0.1263Yes
181ACADMNAACADM
Entrez,  Source
acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain17198-1.057-0.1157Yes
182COL15A1NACOL15A1
Entrez,  Source
collagen, type XV, alpha 117469-1.235-0.1172Yes
183NDUFA5NANDUFA5
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa17656-1.422-0.1120Yes
184PDCD4NAPDCD4
Entrez,  Source
programmed cell death 4 (neoplastic transformation inhibitor)17740-1.515-0.1000Yes
185MGST3NAMGST3
Entrez,  Source
microsomal glutathione S-transferase 317763-1.551-0.0843Yes
186CCNG2NACCNG2
Entrez,  Source
cyclin G218022-2.397-0.0724Yes
187ABCA1NAABCA1
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 118056-2.602-0.0458Yes
188LPLNALPL
Entrez,  Source
lipoprotein lipase18162-4.7450.0003Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_ADIPOGENESIS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_ADIPOGENESIS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_ADIPOGENESIS