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    <h2>Developmental Neurotoxicity Risk Assessment of <a href="https://compoundcloud.wikibase.cloud/wiki/Item:Q2061">Silymarin</a></h2>
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  <p><b>Question:</b> Is there a risk of thyroid-mediated development neurotoxicity through MCT8 inhibition by silychristin when a pregnant woman takes silymarin supplements at a given dose, frequecy and duration (referring to the regulatory question 3a)?</p>

  <br>

  <p> This workflow is being implemented at this page at the moment, you can check out the webapplication <a href="81.169.225.178:5005">here.</a>
  <p>Steps to complete the workflow to answer the question:</p>

  <ol>
  <li> External Exposure Assessment: The tools that assess the magnitude, frequency, duration and exposure routes of a given exposure </li>
    <ul>
      <li>Inputs: Magnitude, frequency, duration of silychristin exposure (numeric variables) and exposure route (categorical variable, e.g. oral) </li>
      <li>No outputs for this specific question.</li>
    </ul>
  <li> Internal Exposure: PBPK Modeling </li>
  <ul>
      <li>Inputs: 
        <ol>
          <li> Chemical properties: fup; Blood Plasma Ratio (BPR); Tissue-Blood partition coefficients for fat, liver, fetus, slowly perfused tissue and richly perfused tissue; CLint Liver S9; the concentration of S9 protein in the incubation; Unbound fraction in the S9 incubation; Scaling factor from S9 to liver; Unbound fraction in the liver; the absorption rate constant across the small intestine; the fraction absorbed across small intestine. These inputs are currently set in the model; however, they can be made user-defined in the final, generalized status of the workflow. </li>
          <li> Biological properties </li>
        </ol>
      </li>
      <li>Outputs: </li>
    </ul>
    <li> Hazard </li>
  <ul>
      <li>Inputs: </li>
      <li>Outputs: </li>
    </ul>
  <li> Report </li>
  <ul>
      <li>Inputs: </li>
      <li>Outputs: </li>
    </ul>
  </ol>
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