A 9-year-old, male, neutered, domestic shorthair cat was presented to his primary veterinarian for lethargy and decreased appetite. Nine months prior to this presentation, the patient had been diagnosed with renal disease; at that time blood urea nitrogen (BUN) had been 107 mg/dL (reference interval [RI] 15–34 mg/dL), creatinine 9.2 mg/dL (RI 0.8–2.3 mg/dL), and urine specific gravity (USG) 1.019. Uroliths had been noted in the record, although no diagnostic imaging reports are available. Following fluid therapy and other supportive care, renal values had improved by the following month to BUN 32 mg/dL and creatinine 2.1 mg/dL. Now on presentation to the primary veterinarian, severe azotemia had recurred with BUN 96 (RI 16–36) and creatinine 11.3 (RI 0.8–2.4 mg/dL). Complete blood count was consistent with a stress leukogram: white blood cells 14×109/L (RI 5.5×109–19.5×109/L), segmented neutrophils 76% (RI 35%–75%), and lymphocytes 14% (RI 20%–45%). Urinalysis identified isosthenuria (USG 1.012), with a normal protein:creatinine ratio of 0.3. No urine culture was performed. An ELISA test was negative for feline immunodeficiency virus antibody, feline leukemia virus antigen, and heartworm antigen. Treatment included fluid therapy and cefovecin 8 mg/kg subcutaneously (SC) (Convenia; Zoetis Inc, Kalamazoo, MI, USA), but on the seventh day of treatment azotemia had worsened, with BUN 201 mg/dL and creatinine 16.2 mg/dL. Abdominal radiographs showed a small right kidney, mildly enlarged left kidney, punctate mineral opacity in the pelvic region of the left kidney, and multiple mineral opacities suggestive of ureteral calculi. The patient was then referred to a specialty hospital (Hospital A). On presentation to Hospital A, a grade II/VI systolic heart murmur was ausculted, and Doppler blood pressure was 160 mmHg. Urine culture was submitted and was negative. Ultrasonography of the abdomen showed bilateral dilation of the renal pelves (right 0.3 cm, left 0.45 cm), left renoliths, left ureteral dilation with ureterolithiasis, decreased cortico-medullary distinction in the kidneys bilaterally, and a right kidney smaller than the left (length in transverse section: right 2.05 cm, left 4.23 cm). Whole body radiographs showed minimal left atrial enlargement and an enlarged, irregular left kidney (6 cm in length) with left-sided nephrolithiasis and ureterolithiasis. Medical therapy was instituted with continued fluid diuresis, amlodipine 0.15 mg/kg by mouth (PO) q24h, ampicillin/sulbactam 22 mg/kg intravenously (IV) q12h, amitriptyline 1.2 mg/kg PO q24h, prazosin 0.06 mg/kg PO q12h, famotidine 0.48 mg/kg IV q24h, buprenorphine 0.007 mg/kg SC q12h, and aluminum hydroxide. After 2 days BUN improved slightly to 179 mg/dL (RI 7–27 mg/dL), but creatinine progressively increased to 18.5 mg/dL (RI 0.5–1.8 mg/dL). Blood pressure increased to 190 mmHg measured via Doppler. Repeat sonography revealed progressive dilation of the left renal pelvis to 0.57 cm (), while the right renal pelvis remained stable. Repeat radiographs showed evidence of fluid overload with a mild increase in the size of the cardiac silhouette and prominent caudal lobar pulmonary vasculature. There were wispy fluid opacities in the retroperitoneal space (). The cat was then referred to a second specialty hospital (Hospital B). On arrival at Hospital B, the patient was tense on palpation of the left kidney and had a grade II/VI heart murmur. He appeared well hydrated, and his mucous membranes, body condition score, and lung sounds were normal. Baseline in-house labwork showed BUN >140 mg/dL (RI 15–34 mg/dL), creatinine 14.9 mg/dL (RI 1.0–2.2 mg/dL), and potassium 3.9 mmol/L (RI 2.9–4.2 mmol/L). Because the patient was presented during emergency hours, echocardiogram was deferred until the following day. Given concern for ureteral obstruction, decompression of the left kidney via subcutaneous ureteral bypass (SUB) or double pigtail ureteral stent was planned. Surgical approach to the abdomen revealed a moderate amount of free abdominal fluid. The left kidney was enlarged and pale in color with vascularization of the renal capsule. The right kidney was small and irregular. In light of the abnormal gross appearance of the left kidney, an aspirate of the left renal cortex for cytology was performed (22 gauge needle, 3 mL syringe). In addition, urine was collected from the renal pelvis for bacterial and fungal culture using a 22 gauge IV catheter. Intraoperative fluoroscopic pyelogram demonstrated a tortuous, dilated proximal ureter with a proximal obstruction. Placement of a ureteral stent was attempted and was discontinued when a 150 cm×0.018 inch guide wire (Weasel Wire; Infiniti Medical LLC, Redwood City, CA, USA) would not feed past the ureterovesicular junction. A SUB device (Norfolk Vet Products, Skokie, IL, USA), consisting of a nephrostomy tube and a cystostomy tube connected by a subcutaneous infusion port, was then placed as described elsewhere. A contrast study confirmed the patency of the system. A Jackson-Pratt drain (MILA International, Florence, KY, USA), 3.5 French red rubber urinary catheter (Covidien LLC, Mansfield, MA, USA), 14 French esophagostomy tube (MILA International) in the left mid-cervical region, and 5.5 French×13 cm triple-lumen catheter (Jorgensen Labs, Loveland, CO, USA) in the right jugular vein were placed. Prior to recovery, a right lateral radiographic projection was obtained to document proper placement of the SUB system (). Immediate postoperative supportive care consisted of a combination of a balanced isotonic crystalloid (Plasmalyte A; Baxter International Inc, Deerfield, IL, USA) and a hypotonic crystalloid (2.5% dextrose and 0.45% sodium chloride; Abbot Laboratories, North Chicago, IL, USA), ticarcillin/clavulanic acid (GlaxoSmithKline, Research Triangle Park, NC, USA) 50 mg/kg IV q8h, gastroprotectants, and analgesia. On postoperative day 1, echocardiogram found left ventricular concentric hypertrophy (left ventricular posterior wall at end diastole 6.59 mm, interventricular septum at end diastole 6.71 mm) consistent with either chronic hypertension or primary hypertrophic cardiomyopathy. Evidence of fluid overload included mild pericardial effusion and mild dilation of all chambers. IV fluid therapy was then minimized, with additional water provided via esophagostomy tube. On postoperative day 2, the urinary catheter was removed. The patient’s renal values initially improved rapidly, with a blood gas on postoperative day 3 showing BUN 65 mg/dL (RI 15–34 mg/dL) and creatinine 2.4 mg/dL (RI 1.0–2.2 mg/dL). Ticarcillin/clavulanic acid was discontinued in favor of amoxicillin/clavulanate (Clavamox; Zoetis Inc) 12.9 mg/kg PO q12h. Four days postoperatively, repeat sonography of the left kidney showed that pyelectasia had resolved (). The patient experienced a urethral obstruction, which was relieved with a 3.5 French red rubber urinary catheter, yet on the following day BUN increased to >140 mg/dL (RI 15–34) and creatinine to 9.3 mg/dL (RI 1.0–2.2 mg/dL). Alanine amino-transferase became elevated (137 U/L; RI 12–130 U/L). The cat developed relative oliguria (urinary output 0.68 mL/kg/hr) and had evidence of continuing fluid overload as indicated by generalized subcutaneous edema and chemosis. Furosemide (Vedco Inc, St Joseph, MD, USA) 1.9 mg/kg IV was given twice, followed by a constant rate infusion of furosemide 0.25 mg/kg/hr. Enrofloxacin (Baytril; Bayer HealthCare LLC, Shawnee Mission, KS, USA) 5 mg/kg IV q24h was added, and amoxicillin/clavulanate was discontinued. The patient inadvertently removed his urethral catheter and was able to urinate productively. Six days postoperatively, renal cytology obtained at the time of surgery became available. Slides were cellular and considered to be of excellent quality. A moderate mixed inflammation of neutrophils, macrophages, and rare eosinophils was present. Oval and occasional budding fungal/yeast organisms were identified free throughout the background and phagocytized by macrophages; the appearance of the organisms was consistent with Candida. Bacterial and fungal cultures of urine aspirated from the renal pelvis at the time of surgery were negative, and a concentrated cytocentrifuge urine preparation for cytology was only sparsely cellular with no infectious organisms observed. Treatment for fungal infection was started with fluconazole oral suspension (Greenstone LLC, Peapack, NJ, USA) 7 mg/kg enterally q12h. Enrofloxacin was discontinued. On the same day, the port of the SUB system obstructed with debris and was exchanged under anesthesia. On postoperative day 7, the patient’s packed cell volume decreased to 15% with total protein 6.2 g/dL. A transfusion of packed red blood cells (35 mL) was administered without complication following doses of furosemide 2 mg/kg IV and dexamethasone SP (Bimeda-MTC Animal Health Inc, Cambridge, Ontario, CA) 0.1 mg/kg IV. On postoperative day 8, creatinine and potassium continued to rise, and the patient showed evidence of progressive fluid overload, now including the development of pleural effusion. Thoracocentesis yielded 110 mL of pleural fluid. Kidney values peaked postoperatively on day 9 (3 days after starting fluconazole), with BUN >140 mg/dL (RI 15–34 mg/dL) and creatinine 11.6 mg/dL (RI 1.0–2.2 mg/dL). Following this time azotemia improved rapidly; on day 13, BUN was 56 mg/dL and creatinine 2.8 mg/dL (). Ultrasound showed scant perirenal fluid on the left. The SUB system was flushed, demonstrating normal flow. The patient was discharged home, and fluconazole was continued for 3 months. Twelve weeks postoperatively, the patient experienced clinical signs of hyporexia and vocalization while eating, with a feline pancreatic lipase (Spec fPL; IDEXX Laboratories, Westbrook, ME, USA) of 32 µg/L (RI 0–3.5 µg/L). There was no obstruction of the SUB or urethra, and no renal pelvic dilation when examined sonographically. A urine culture at the same time grew Enterococcus >100,000 organisms/mL. The patient was successfully treated for presumptive pancreatitis and the urinary tract infection. Five months postoperatively, the patient was doing well with creatinine 2.5 mg/dL and BUN 39 mg/dL; bacterial and fungal cultures of urine were negative. Seven months postoperatively, the patient’s renal values increased again (creatinine 5.6 mg/dL, BUN 70 mg/dL). His SUB system remained patent, and bacterial urine culture was negative; fungal urine culture was not repeated. Fluconazole was resumed (6.8 mg/kg PO q12h), and 1 week thereafter renal values again decreased (creatinine 3.1 mg/dL, BUN 37 mg/dL). Eleven months (338 days) postoperatively, the patient was euthanized due to progression of his kidney disease despite systemic antifungal therapy and a patent SUB system. Postmortem histopathology of the kidney showed chronic interstitial fibrosis with tubulointerstitial nephritis, glomerulonephritis, and tubular dilation; these changes are consistent with chronic pyelonephritis and obstructive disease. No organisms were found on Grocott/Gimori’s methenamine silver stain, and fungal culture of renal tissue was negative.