A 17-year and 6-month old girl was referred to our Endocrinology Clinic for the evaluation of primary amenorrhea, short stature and reduced general condition. she issued from a low socio-economic status family. She is the first child of 6 children family. There was no history of chronic diarrhea, vomiting, drug intake or any central nervous symptoms such as headaches or visual disturbances. There was no significant familial medical history. There was no familial history of delayed puberty. On physical examination she was conscious,very thin, pale with no special facies. Her heart rate was 110 b/m and her blood pressure was 110/65 mm Hg. She attend tanner 5 stage. Her height was 143 cm (0.1% percentile), her weight was 35 kg (0.1% percentile) and her Body mass index (BMI) was 17.1 kg/m2 (3.3 percentile). There were neither hepatosplenomegaly, nor lymphadenopathy. Her initial laboratory workup showed severe anemia, a hemoglobin electrophoresis revealed no hemoglobinopathy. We observe values of FSH and LH corresponds to tanner 5, low value of IGF1 and a high value of anti-tissue transglutaminase antibody (Anti TTG IgA). Her bone age corresponds to 15 years (Greulich & Pyle). An gynecological consultation with trans-abdominal sonography of the uterus and ovaries was normal. Based on the previous results, the patient underwent an upper gastrointestinal endoscopy which showed March3c type on small intestinal biopsies confirming Celiac disease. A gluten-free diet was advised along with multi-vitamin supplementation: Fe (5mg/kg/day), B9 (1 mg/kg/day) and vitamin D. The patient was not allowed to eat certain grains that contain gluten such as wheat, barley and foods that contain ingredients made from these grains such as breads, cereals, pastas and Drinks such as beer. We gave her a brochure that includes many foods are free of gluten, including meat, fish, fruits, vegetables, rice, and potatoes. It's acceptable to consume flour produced from beans, potatoes, rice, corn, soy, almonds, cassava, amaranth, quinoa, or corn. These products are provided by several grocery stores and specialized food businesses. Four months later, the patient's condition significantly improved. she gained weight (3.5Kg), hemoglobin was 9.5 g/100 ml, and she reached her first menarche at the age of 17-year and 10-month.