A 29-year-old woman from Kumba, Cameroon, was admitted in January 2004 to St. John's Hospital and Maternity, Kumba, with a five-day history of fever, emesis, poorly localized abdominal discomfort, myalgias and hepatosplenomegaly. Her total leukocyte count was 1.7 × 109/l, (neutrophils 51%, lymphocytes 43%, monocytes 5%). Urinalysis was normal and thin and thick film examinations of the peripheral blood were negative for malaria. The patient also tested negative for HIV. A blood Widal test however, showed a titre of 80 against "O" (somatic) antigen and 160 against the "H" (flagella) antigen of Salmonella enterica serovar Typhi (recommended cut-off titre in our hospital: ≥ 1:80 and ≥ 1:160 for the "O" and "H" antigens respectively). Blood culture grew Salmonella enterica serovar Typhi. Two months prior to her illness, she had suffered from an attack of suspected typhoid fever and had been treated with chloramphenicol 500 mg every 6 hours for 14 days. Antibiogram of the isolated S. enterica serovar Typhi was performed by disc diffusion techniques as recommended by NCCLS guidelines [], Minimum inhibitory concentrations (MIC) of nalidixic acid and ciprofloxacin were determined by agar dilution method []. The antibiotic discs used included ampicillin 10 μg (Beecham), co-trimoxazole 1.25/23.75 μg (Roche), chloramphenicol 30 μg (Antibioticos SA), ciprofloxacin 5 μg (Bayer), nalidixic acid 30 μg (Sigma) and ceftriaxone 30 μg (Roche). The isolate was found resistant to nalidixic acid, ampicillin, co-trimoxazole and chloramphenicol, but susceptible to ceftriaxone and ciprofloxacin by disc diffusion test. The MICs of ciprofloxacin and nalidixic acid were 0.5 μg/ml and 32.0 μg/ml respectively. The patient remained febrile after 7 days of oral administration of 500 mg ciprofloxacin every 12 hours. Thereafter, the patient was administered 1 g ceftriaxone every 12 hours intravenously, which rendered her afebrile within four days. Treatment was continued for another 3 days. The patient did not relapse on follow-up.