A 27-year-old female with acute gastroenteritis was admitted to Kasturba Hospital, Manipal, India. She was suffering from lupus nephritis class IV and on a NIH (National Institute of Health) protocol for 6 months. The patient was on a treatment regime with four cycles of cyclophosphamide (700 mg for 2 weeks) and she was due to receive the fifth pulse of cyclophosphamide. On admission, she had complaints of loose stools, vomiting, abdominal pain and fever for 1 day. Stools passed were watery with no mucus and blood. She had a history of oral candidiasis, upper respiratory tract infection and leucopenia.