A 52-year-old female patient was referred to our institution with persistent pain of the right humerus due to recurrent implant failure and non-union of the right humerus Ten years previously, the fracture area she was being treated for, had been diagnosed with a grade 2 Leiomyosarcoma. After surgical resection and free tissue transfer (groin flap for covering), a post-operative radiotherapy with 60Gy in 30 fractions was prescribed. The patient then sustained a closed fracture of the right humeral shaft whilst lifting a light object. The fracture was then stabilised with a retrograde nail but fixation failed after 18 mo. The fracture was next revised to a double plate fixation and biological en-hancement was achieved with the implantation of autologous bone grafting harvested from the pelvic iliac crest. However, 14 mo after the revision, the patient presented with non-union associated with implant failure and was referred to our institution. The patient had a free previous medical history. The patient showed movement dependent pain of the right upper arm. Due to the implanted double plate fixation there was no instability. After radiation and previous surgery the skin was compromised by massive scar tissue formations. The patient showed no clinical signs of infection and no neurological deficits. Blood analysis as well as urine analysis were normal. Electrocardiogram, chest X-ray and arterial blood gas were also normal. A staging computed tomography and magnetic resonance imaging scan of the upper arm showed no local recurrence or metastatic disease.