A 34-year-old woman presented to our department with severe, painful erythema and hyperpigmentation of her face and neck. Her initial physical examination revealed isolated erosions of her forehead. She reported that a facial 70% glycolic acid peel had been performed 3 days prior to her examination at our clinic. According to her medical history, she had received repetitive treatments with 70% glycolic acid without any discomfort or complications for the past several months. Prepeel preparations had been performed with 8% glycolic acid. During the postpeel period, bland emollients as well as sunscreens had been applied. At the initial referral, persistent questioning revealed a history of treatment with 10 mg of isotretinoin three times per week because of a coarse-pored skin for the preceding 10 weeks. Systemic isotretinoin was discontinued 3 weeks prior to her last session of CP. It must be noted that the patient had initiated the isotretinoin treatment on her own behalf without consulting her dermatologist. She had not used oral contraception, estrogens or other photosensitizing agents. The patient stated that she had maintained strict avoidance of ultraviolet light exposure prior to her CP procedure as well as in the postpeel period. After her initial examination, a topical treatment with fusidic acid in combination with methylprednisolone aceponate lotion twice per day was initiated. Subsequently, significant reduction in exudation and improvement of erythema were observed. However, late-onset adverse effects, including postinflammatory hyperpigmentation and scarring, persisted even 2 months after chemical peel treatment.