A 50-year-old Chinese woman reported the presence of a cough associated with a small amount of sputum for the previous month, and a fever over the previous week. A physical examination and laboratorytests showed no abnormal findings. When a posteroanterior chest radiograph was obtained, a widened mediastinum, a mass protruding from the pulmonary segment were detected. Using contrast-enhanced computed tomography (CT), a 9 × 11 cm2 lobulated mass exhibiting heterogeneous enhancement and punctate calcification with sharp margins was observed. The capsule of the mass was enhanced in the CT images. The mass was located in the pretracheal space and aortopulmonary window, directly adjacent to, and displacing, the superior vena cava (SVC), ascending and descending aorta, pulmonary artery, left atrium, trachea, and primary bronchi. In addition, small amounts of pericardial and left pleural effusion were observed. Complete surgical resection was performed via a thoracotomy approach. The resected intrapericardial tumor was large in size and firm. The tumor was situated under the ascending aorta, with its right edge adhered to SVC, and was compressing the SVC and right atrium. The upper edge of the tumor was adjacent to the aortic arch, the left edge was attached to the pericardium and left hilus of lung, the lower edge was adhered to left atrium and pulmonary artery, and the posterior edge was adjacent to the trachea, primary bronchi and the descending thoracic aorta, The tumor compressed the trachea and was pushing the primary bronchi toward the vertebral column. The tumor exhibited lobulation and capsulation. Correspondingly, no infiltration of adjacent organs was observed. Histological examination revealed that the tumor was made up of two tissue types: Antoni A and Antoni B. The Antoni A type tissue was composed of spindle cells that were closely packed together and arranged in bundles and rows with palisading nuclei without mitoses. The Antoni B type tissue had a low density of cells that were dispersed in a loose and random fashion; the tumor cells were polygonal with abundant cytoplasm, cytoplasmic lipids, and had round or oval nuclei. The tumor cells were strongly immuno positive for S-100 protein.Based on these results, a diagnosis of benign pericardial schwannoma was made. The patient’s general health was good. She exhibited no evidence of recurrence at a follow-up CT scan performed 5 months after the surgical resection.