A 65-year-old female patient with previous abdominal surgery in a regional hospital in Bahir Dar 6 months prior to this presentation presented with diffuse abdominal pain, weakness, and occasional vomiting of ingested material of 6 months duration. There was no history of abnormal uterine bleeding, oral contraceptive use, or gynecologic operation. The patient gave written informed consent to publish this case report. The biopsy result of her surgery in Bahir Dar was suggestive of gastrointestinal stromal tumor. On examination, she looked chronically sick, was emaciated and slightly pale and had a long midline abdominal scar; there was also mild tenderness all over the abdomen on deep palpation. Investigation revealed a hemoglobin value of 9.3 g/dL and a WBC count of 6,900/μL. She had O +ve blood group and had normal liver and renal function as well as a normal chest X-ray. Ultrasound showed enumerable hypoechoic intra- abdominal masses of different sizes () and a large hypoechoic liver mass measuring 7.5×4.7 cm2 in the right lobe (). Laparotomy later revealed innumerable globular masses arising from the mesentery and walls of whole small bowel, some pedunculated but most sessile ( and ). In addition, there was a large liver mass of approximately 8×10 cm in the right lobe with normal pelvis. Multiple biopsies were taken from the mesenteric and superficial small intestinal masses but not from the liver mass for fear of bleeding and abdomen closure. Biopsy specimens were sent to two centers, and both reported a similar finding of highly cellular interlacing bundles of proliferating smooth muscle cells not associated with nuclear atypia or mitotic figures, and there was no necrosis seen. The overall picture suggests cellular leiomyoma of undetermined biologic behavior. Further surgery was differed as it is impractical to remove all masses. The patient was discharged with no major complication, and a diagnosis of LPD with possible liver leiomyoma was made. An oncologic consultation was done later. The patient was followed up for 3 months, and she still has some abdominal pain but was doing fine in general.