A 49-years old female diagnosed with HIV infection 8 years ago under regular ART (anti-retroviral therapy) went to our clinic for fatigue (day 1 of illness). He got a fever (day 4) with a maximum temperature of 38 ℃, accompanied by pharyngeal pain. The patient showed chills on day 5. Considering the clinical symptoms, the sputum sample was collected for RT-PCR assay of SARS-CoV-2 and the chest computed tomography (CT) was performed. Previous medical history included syphilis, which was cured. The ART is Efavirenz 600 mg, Zidovudine 300 mg, and Lamivudine 150 mg. After that, she continued the ART regularly. Although the nadir CD4 + T cell count was 224, a recent test was normal. The HIV viral load remained undetectable from 2013. The CT result showed ground glass dense shadow and cord shadow under the pleura of the lateral segment of the middle lobe and dorsal-base segment of the lower lobe of the right lung. Meantime, he was treated with cefuroxime and traditional Chinese medicine (Lianqin oral solution and Lianhua Qingwen capsule). At that time, the result of RT-PCR for SARS-CoV-2 was negative. But the symptoms were not relieved. We considered the possibility of false-negative to the RT-PCR result []. So, we had a re-check of RT-PCR for SARS-CoV-2 on day 7. The test result on day 7 turned positive, and the patient was diagnosed with COVID-19 (moderate type). According to the Chinese COVID-19 treatment guideline at that time [], on Day 8, we changed the cefuroxime and traditional Chinese medicine to interferon atomization (5 million bid), ribavirin (150 mg TID), and abidol (200 mg TID) for antiviral treatment. Meanwhile, the moxifloxacin (400 mg QD) was given to the patient for preventing bacterial infection. On day 12, the temperature of the patient returned to normal. The symptoms of the patient alleviated completely, and the result of the CT scan on day 15 was also back to normal. We consistently tested the RT-PCR for COVID-19 on day 19, day 25, and day 31 to 34, but all the results remained positive. The RT-PCR for COVID-19 turned negative for the first time on the day 35. Meantime, the IgM antibody for SARS-CoV-2 on day 35 was positive. Then we tested the RT-PCR and IgM for SARS-CoV-2 every 3 days. The RT-PCR for SARS-CoV-2 remained negative, while the IgM antibody for SARS-CoV-2 turned negative on day 44. We confirmed the viral clearance, and the patient was discharged on day 47.