A 1-year-old spayed mix-breed female cat was consulted to the Veterinary Endoscopy Service for recurring regurgitation after two previous esophageal dilatations. The cat had received doxycycline for a Mycoplasma spp. infection and 20 days after the treatment consulted for dysphagia and regurgitation. Two separate dilatations occurred in other endoscopy services; information regarding the level of the stricture or type of dilatation technique was not available. The only information available about the procedures was that the owner mentioned an initial 3 mm stricture; however, the final diameter was unknown. After 15 days from the last dilatation, they consulted the service. Upper esophagogastroscopy (UGE) was performed under general anesthesia with an Olympus CV-160 8.7 mm diameter endoscope. For general anesthesia, a catheter was placed in the right cephalic antebrachial vein and was induced by intravenous (IV) injection of propofol 6 mg/kg (Propofol Gray®; Productos Farmacéuticos Dr. Gray S. A. C. I., Argentina) and isoflurane 5% (Forane® Isoflurane; Abbott Laboratories, Argentina). The trachea was intubated, and anesthesia was maintained with isoflurane (Forane® Isoflurane; Abbott Laboratories, Argentina) in 100% oxygen using a Bain breathing system. After the monitoring equipment was connected, a fentanyl bolus 2 μg/kg (Fentanilo Gray®; Productos Farmacéuticos Dr. Gray S. A. C. I.) was administered. Monitoring included a lead II electrocardiogram which was used to derive heart rate, pulse oximetry, noninvasive mean arterial pressure, and rectal temperature (PDJ-3000A Multi-Parameter ICU Portable Patient Monitor, Nanjing Puao Medical Equipment Co., Ltd.). NaCl solution 0.9% (Laboratorio P.L. Rivero & Cía®. S.A.I.C, Argentina) was administered IV at 5 ml/kg/hour during anesthesia, and maropitant 1 mg/kg subcutaneous (SC) (Cerenia®, maropitant 10 mg/ml; Zoetis Inc., MI, USA) and tramadol 2 mg/kg IV (Algen® 20, Tramadol 20 mg/ml; Richmond Vet Pharma, Argentina) were also administered. During UGE, a 7 mm annular stricture was observed 3 cm caudal to the cranial esophagus sphincter. The approximate diameter was measured by the comparison of the tip of a grasping forceps. Three balloon dilatation procedures were performed with a Boston Scientific Controlled Radial Expansion (CRE) balloon 8–10–12 mm, held for 1 minute at each diameter (). Between dilatations, the balloon was deflated for 30 seconds to allow mucosal reperfusion. Efficacy of the dilatation in every diameter was evaluated by macroscopic mucosal damage, drawing the attention to bleeding or tearing and intact mucosa. The endoscope traversed the dilatation with no stop at the end of the procedure. Afterward, gastroscopy was unremarkable. Anesthetic recovery was successful with no complications. The cat was discharged with indications for oral administration of 0.5 g sucralfate every 8 hours and to start oral wet feeding after 6 hours. The cat could eat soft food normally for 6 days, and thereafter it started with oral dysphagia and regurgitation; by day 10, it could only eat fluids and still had dysphagia. Another UGE under general anesthesia was performed 15 days from the first procedure with our service. A 3 mm stricture was encountered in the same place, and balloon dilatation was repeated with 6–10–12 mm diameter and a four-quadrant 0.3 ml of triamcinolone acetate 40 mg/ml was injected using a per-endoscopic needle (Disposable Injector NM-200 L, Olympus Medical Systems Corp®., Tokyo, Japan) in the submucosa. The procedure and the efficacy of the dilatation were performed as before. Anesthetic protocol and recovery were unremarkable. Clinically, the cat could eat with no alterations until day 20, where it started with mild dysphagia. Another UGE with the same anesthetic protocol was performed; the known stricture conserved a 11 mm diameter and balloon dilatation of 12–15–16.5 mm with triamcinolone injection was repeated 30 days after the previous procedure. The cat could eat kibbles as a normal diet with weight gain with no clinical signs until an 11-month follow-up after the last treatment.