An eighty-two-year-old man with end-stage renal failure due to polycystic kidney disease was newly started on PD. He was put on intermittent PD two weeks after PD catheter insertion and was later started on continuous ambulatory peritoneal dialysis at one month. His PD regimen consisted of 1.5% 2L Dianeal® (Baxter) PDF three bags exchanged per day. He was admitted to the hospital 19 days later for turbid PDF effluent. The total PDF effluent WBC count was 5643/mm3, with 29% neutrophils, 2% lymphocytes, 13% monocytes and 56% eosinophils. He did not have fever or abdominal pain. Intraperitoneal vancomycin and amikacin were started empirically upon admission. Antibiotics were chosen in view of the patient’s known allergies to penicillin, erythromycin and levofloxacin. He had also been taking amlodipine, lisinopril, terazosin, frusemide, ferrous sulphate, pantoprazole, vitamin B complex, vitamin C and methoxy polyethylene glycol epoetin beta subcutaneous injection. There had been no change in medications since PD catheter insertion. The bacterial and fungal cultures of the PDF effluent and a polymerase chain reaction test for Mycobacterium tuberculosis complex DNA were all negative. However, the PDF effluent was persistently turbid with a marked decrease in ultrafiltration. Eosinophilic peritonitis due to an allergic reaction was suspected. All intraperitoneal antibiotics were stopped, with oral chlorpheniramine prescribed on day 11 after admission. The PDF effluent remained turbid, with a total WBC count ranging from 5000-6000/mm3. We switched the 1.5% 2L Dianeal® (Baxter) PDF to 1.5% 2L Stay Safe Balance® (Fresenius) PDF on day 14 after admission. There was significant improvement in the turbidity of the PDF effluent the next day (total WBC count 1320/mm3, eosinophils 72%), and it eventually cleared up on day 19 (total WBC count 40/mm3). There was no recurrence of turbid PDF effluent until the latest follow-up at one month after discharge.