The Case 1 was a 90-year-old man, affected with hypertension and senile dementia, who tested positive for SARS-CoV-2 by reverse transcriptase–polymerase chain reaction (RT-PCR) from a nasopharyngeal swab on April 2th, 2020, after three days of fever and cough. On April 4th he was hospitalized and after eleven days transferred to Intensive Care Unit (ICU) due to the severe dyspnea, requiring intubation. A chest CT showed bilateral ground-glass opacities in upper and lower lobes. Just that day, an erythematous maculo-papular rash appeared on trunk, shoulders and neck, becoming purpuric after few days. On April 23th, five biopsy specimens from the back and upper limbs were obtained. Histological evaluations revealed a chronic superficial dermatitis with purpuric aspects. The superficial and papillary dermis appeared edematous, with a perivascular lympho-granulocytic infiltrate and erythrocytic extravasation. At intraepithelial level, spongiosis and a granulocyte infiltrate were detected. Arterioles, capillaries and post-capillary venules showed endothelial swelling and appeared ectatic. The patient was treated with hydroxychloroquine, azithromycin, lopinavir-ritonavir and tocilizumab. Regrettably, due to severe lung impairment, he died on April 25th. The Case 2 was a severely dyspneic 85-year-old man, with a history of hypertension, cerebral vasculopathy, prostate cancer, admitted to ICU on April 19th, where he was intubated. He had tested positive for SARS-CoV-2 by RT-PCR from a nasopharyngeal swab on April 17th, after five days of fever, cough and sore throat. A chest RX showed bilateral atypical pneumonia. On April 24th, a cutaneous reddening involving trunk, upper limbs, neck and face developed, configuring progressively a sub-erythroderma, with mild exfoliation. After three days, four biopsy specimens were obtained. Histological evaluations displayed edema in the papillary and superficial reticular dermis, and a perivascular lymphocytic infiltrate in the superficial dermis. The patient was treated with hydroxychloroquine, azithromycin, lopinavir-ritonavir and tocilizumab. Sub-erythroderma as well as respiratory symptoms gradually improved until healing, with the hospital discharge occurring on May 5th.