# Figure 14-5.01 KM Plot - TLF Specification

## Header
- **Figure ID**: 14-5.01
- **Title**: Kaplan-Meier Plot of Time to First Dermatologic Event - Safety Population
- **Population**: Safety Population (N=254)

## Endpoint
- **Parameter**: TTDE (Time to First Dermatologic Event)
- **Dataset**: ADTTE
- **Time variable**: AVAL (days)
- **Event variable**: CNSR (0=event, 1=censored)

## Treatment Display
| Group | Line Style | Color |
|-------|-----------|-------|
| Placebo | Solid | - |
| Xanomeline Low Dose | Dashed | - |
| Xanomeline High Dose | Dotted | - |

## Axis Specifications
- **X-axis**: Time (days)
- **Y-axis**: Survival Probability (0.0 - 1.0)
- **Reference line**: y = 0.5

## Risk Table
- Number-at-risk displayed below the plot
- Rows: one per treatment group
- Columns: time intervals

## Statistical Summary Table
| Statistic | Content |
|-----------|---------|
| N | Subjects per treatment group |
| Events | Number of events per group |
| Median (95% CI) | Median time to event |
| Log-rank p-value | Overall comparison |

## Additional Elements
- Censoring marks: tick marks on survival curves
- 95% CI bands: displayed as shaded regions
- No multiplicity adjustment applied

## Data Source
- **Dataset**: ADTTE
- **Parameter**: PARAMCD = 'TTDE'
- **Population filter**: SAFFL = 'Y'
