## New Classes

 * [MONDO:0021421](http://purl.obolibrary.org/obo/MONDO_0021421) carcinoid tumors, intestina
 * [MONDO:0025351](http://purl.obolibrary.org/obo/MONDO_0025351) multiple congenital anomalies-neurodevelopmental syndrome, x-linked
 * [MONDO:0025356](http://purl.obolibrary.org/obo/MONDO_0025356) azoospermia, obstructive, with nephrolithiasis
 * [MONDO:0025622](http://purl.obolibrary.org/obo/MONDO_0025622) Charcot-Marie-Tooth disease, axonal, mitochondrial form, 1
 * [MONDO:0030835](http://purl.obolibrary.org/obo/MONDO_0030835) developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy
 * [MONDO:0030837](http://purl.obolibrary.org/obo/MONDO_0030837) neurodevelopmental disorder with microcephaly, impaired language, epilepsy, and gait abnormalities
 * [MONDO:0030849](http://purl.obolibrary.org/obo/MONDO_0030849) intellectual developmental disorder with speech delay and axonal peripheral neuropathy
 * [MONDO:0030852](http://purl.obolibrary.org/obo/MONDO_0030852) neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities
 * [MONDO:0030859](http://purl.obolibrary.org/obo/MONDO_0030859) COACH syndrome 2
 * [MONDO:0030860](http://purl.obolibrary.org/obo/MONDO_0030860) neuronopathy, distal hereditary motor, type 5C
 * [MONDO:0030862](http://purl.obolibrary.org/obo/MONDO_0030862) COACH syndrome 3
 * [MONDO:0030866](http://purl.obolibrary.org/obo/MONDO_0030866) neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities
 * [MONDO:0030871](http://purl.obolibrary.org/obo/MONDO_0030871) vertebral hypersegmentation and orofacial anomalies
 * [MONDO:0030873](http://purl.obolibrary.org/obo/MONDO_0030873) cardiofacioneurodevelopmental syndrome
 * [MONDO:0030878](http://purl.obolibrary.org/obo/MONDO_0030878) Kaya-Barakat-Masson syndrome
 * [MONDO:0030880](http://purl.obolibrary.org/obo/MONDO_0030880) mandibuloacral dysplasia progeroid syndrome
 * [MONDO:0030885](http://purl.obolibrary.org/obo/MONDO_0030885) amyotrophic lateral sclerosis 26 with or without frontotemporal dementia
 * [MONDO:0030893](http://purl.obolibrary.org/obo/MONDO_0030893) leukoencephalopathy, progressive, infantile-onset, with or without deafness
 * [MONDO:0030896](http://purl.obolibrary.org/obo/MONDO_0030896) chromosome 13q33-q34 deletion syndrome
 * [MONDO:0030897](http://purl.obolibrary.org/obo/MONDO_0030897) Lessel-Kreienkamp syndrome
 * [MONDO:0030900](http://purl.obolibrary.org/obo/MONDO_0030900) intellectual developmental disorder with paroxysmal dyskinesia or seizures
 * [MONDO:0030930](http://purl.obolibrary.org/obo/MONDO_0030930) neurodevelopmental disorder with or without early-onset generalized epilepsy
 * [MONDO:0030947](http://purl.obolibrary.org/obo/MONDO_0030947) neurodegeneration, childhood-onset, with hypotonia, respiratory insufficiency, and brain imaging abnormalities
 * [MONDO:0030963](http://purl.obolibrary.org/obo/MONDO_0030963) Li-Campeau syndrome
 * [MONDO:0030966](http://purl.obolibrary.org/obo/MONDO_0030966) neurofacioskeletal syndrome with or without renal agenesis
 * [MONDO:0030967](http://purl.obolibrary.org/obo/MONDO_0030967) deafness, congenital, and adult-onset progressive leukoencephalopathy
 * [MONDO:0030976](http://purl.obolibrary.org/obo/MONDO_0030976) oculomotor-abducens synkinesis
 * [MONDO:0030977](http://purl.obolibrary.org/obo/MONDO_0030977) neuropathy, hereditary motor, with myopathic features
 * [MONDO:0030978](http://purl.obolibrary.org/obo/MONDO_0030978) endove syndrome, limb-only type
 * [MONDO:0030979](http://purl.obolibrary.org/obo/MONDO_0030979) endove syndrome, limb-brain type
 * [MONDO:0030982](http://purl.obolibrary.org/obo/MONDO_0030982) sulfide quinone oxidoreductase deficiency
 * [MONDO:0030986](http://purl.obolibrary.org/obo/MONDO_0030986) blistering, acantholytic, of oral and laryngeal mucosa
 * [MONDO:0030987](http://purl.obolibrary.org/obo/MONDO_0030987) vertebral, cardiac, tracheoesophageal, renal, and limb defects
 * [MONDO:0030988](http://purl.obolibrary.org/obo/MONDO_0030988) developmental delay with dysmorphic facies and dental anomalies
 * [MONDO:0030990](http://purl.obolibrary.org/obo/MONDO_0030990) Kohlschutter-Tonz syndrome-like
 * [MONDO:0030991](http://purl.obolibrary.org/obo/MONDO_0030991) bile acid conjugation defect 1
 * [MONDO:0030992](http://purl.obolibrary.org/obo/MONDO_0030992) short stature, oligodontia, dysmorphic facies, and motor delay
 * [MONDO:0030994](http://purl.obolibrary.org/obo/MONDO_0030994) neurodevelopmental disorder with or without autism or seizures
 * [MONDO:0030995](http://purl.obolibrary.org/obo/MONDO_0030995) global developmental delay with speech and behavioral abnormalities
 * [MONDO:0030999](http://purl.obolibrary.org/obo/MONDO_0030999) neurodevelopmental disorder with cerebral atrophy and variable facial dysmorphism
 * [MONDO:0031001](http://purl.obolibrary.org/obo/MONDO_0031001) vitreoretinopathy with phalangeal epiphyseal dysplasia
 * [MONDO:0031002](http://purl.obolibrary.org/obo/MONDO_0031002) Baralle-Macken syndrome
 * [MONDO:0031006](http://purl.obolibrary.org/obo/MONDO_0031006) neurodegeneration with ataxia and late-onset optic atrophy
 * [MONDO:0031007](http://purl.obolibrary.org/obo/MONDO_0031007) spondyloepiphyseal dysplasia, sensorineural hearing loss, impaired intellectual development, and leber congenital amaurosis
 * [MONDO:0031008](http://purl.obolibrary.org/obo/MONDO_0031008) nephrotic syndrome, type 24
 * [MONDO:0031011](http://purl.obolibrary.org/obo/MONDO_0031011) neurodevelopmental disorder with dysmorphic facies and variable seizures
 * [MONDO:0100283](http://purl.obolibrary.org/obo/MONDO_0100283) overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes
 * [MONDO:0100348](http://purl.obolibrary.org/obo/MONDO_0100348) neurodevelopmental disorder with microcephaly, impaired language, and gait abnormalities
 * [MONDO:0100349](http://purl.obolibrary.org/obo/MONDO_0100349) COACH syndrome
 * [MONDO:0100350](http://purl.obolibrary.org/obo/MONDO_0100350) neuronopathy, distal hereditary motor, type 5
 * [MONDO:0100352](http://purl.obolibrary.org/obo/MONDO_0100352) episodic kinesigenic dyskinesia 1
 * [MONDO:0400006](http://purl.obolibrary.org/obo/MONDO_0400006) botryomycosis
 * [MONDO:0500000](http://purl.obolibrary.org/obo/MONDO_0500000) episodic angioedema with eosinophilia
 * [MONDO:0600001](http://purl.obolibrary.org/obo/MONDO_0600001) glutaminase deficiency
 * [MONDO:0600002](http://purl.obolibrary.org/obo/MONDO_0600002) hemorrhagic fever
 * [MONDO:0600003](http://purl.obolibrary.org/obo/MONDO_0600003) bacterial hemorrhagic fever
 * [MONDO:0600005](http://purl.obolibrary.org/obo/MONDO_0600005) venom allergy
 * [MONDO:0600008](http://purl.obolibrary.org/obo/MONDO_0600008) cytokine release syndrome
 * [MONDO:0600009](http://purl.obolibrary.org/obo/MONDO_0600009) severe hypophosphatasia
 * [MONDO:0600010](http://purl.obolibrary.org/obo/MONDO_0600010) moderate hypophosphatasia
 * [MONDO:0600011](http://purl.obolibrary.org/obo/MONDO_0600011) mild hypophosphatasia

## Obsoletions

 * [MONDO:0007189](http://purl.obolibrary.org/obo/MONDO_0007189) B-cell growth factor --> obsolete B-cell growth factor
 * [MONDO:0007494](http://purl.obolibrary.org/obo/MONDO_0007494) episodic kinesigenic dyskinesia 1 --> obsolete episodic kinesigenic dyskinesia 1
 * [MONDO:0007798](http://purl.obolibrary.org/obo/MONDO_0007798) adult hypophosphatasia --> obsolete adult hypophosphatasia
 * [MONDO:0009325](http://purl.obolibrary.org/obo/MONDO_0009325) deafness-enamel hypoplasia-nail defects syndrome --> obsolete deafness-enamel hypoplasia-nail defects syndrome
 * [MONDO:0009427](http://purl.obolibrary.org/obo/MONDO_0009427) infantile hypophosphatasia --> obsolete infantile hypophosphatasia
 * [MONDO:0009428](http://purl.obolibrary.org/obo/MONDO_0009428) childhood hypophosphatasia --> obsolete childhood hypophosphatasia
 * [MONDO:0010990](http://purl.obolibrary.org/obo/MONDO_0010990) Cd4/CD8 T-cell ratio --> obsolete Cd4/CD8 T-cell ratio
 * [MONDO:0014763](http://purl.obolibrary.org/obo/MONDO_0014763) Bombay phenotype --> obsolete Bombay phenotype
 * [MONDO:0016343](http://purl.obolibrary.org/obo/MONDO_0016343) unclassified cardiomyopathy --> obsolete unclassified cardiomyopathy
 * [MONDO:0016606](http://purl.obolibrary.org/obo/MONDO_0016606) prenatal benign hypophosphatasia --> obsolete prenatal benign hypophosphatasia
 * [MONDO:0023052](http://purl.obolibrary.org/obo/MONDO_0023052) ectrodactyly polydactyly --> obsolete ectrodactyly polydactyly
 * [MONDO:0030965](http://purl.obolibrary.org/obo/MONDO_0030965) olmsted syndrome 2 --> obsolete olmsted syndrome 2

## Renaming

 * [MONDO:0007189](http://purl.obolibrary.org/obo/MONDO_0007189) B-cell growth factor --> obsolete B-cell growth factor
 * [MONDO:0007494](http://purl.obolibrary.org/obo/MONDO_0007494) episodic kinesigenic dyskinesia 1 --> obsolete episodic kinesigenic dyskinesia 1
 * [MONDO:0007798](http://purl.obolibrary.org/obo/MONDO_0007798) adult hypophosphatasia --> obsolete adult hypophosphatasia
 * [MONDO:0008996](http://purl.obolibrary.org/obo/MONDO_0008996) Joubert syndrome with hepatic defect --> COACH syndrome 1
 * [MONDO:0009120](http://purl.obolibrary.org/obo/MONDO_0009120) marfanoid syndrome, De Silva type --> diverticulosis of bowel, hernia, and retinal detachment
 * [MONDO:0009325](http://purl.obolibrary.org/obo/MONDO_0009325) deafness-enamel hypoplasia-nail defects syndrome --> obsolete deafness-enamel hypoplasia-nail defects syndrome
 * [MONDO:0009427](http://purl.obolibrary.org/obo/MONDO_0009427) infantile hypophosphatasia --> obsolete infantile hypophosphatasia
 * [MONDO:0009428](http://purl.obolibrary.org/obo/MONDO_0009428) childhood hypophosphatasia --> obsolete childhood hypophosphatasia
 * [MONDO:0010990](http://purl.obolibrary.org/obo/MONDO_0010990) Cd4/CD8 T-cell ratio --> obsolete Cd4/CD8 T-cell ratio
 * [MONDO:0011175](http://purl.obolibrary.org/obo/MONDO_0011175) friedreich ataxia 2 --> Friedreich ataxia 2
 * [MONDO:0014763](http://purl.obolibrary.org/obo/MONDO_0014763) Bombay phenotype --> obsolete Bombay phenotype
 * [MONDO:0014805](http://purl.obolibrary.org/obo/MONDO_0014805) 16p13.2 microdeletion syndrome --> Hao-Fountain syndrome
 * [MONDO:0015667](http://purl.obolibrary.org/obo/MONDO_0015667) unclassified acute myeloid leukemia --> acute myeloid leukemia by FAB classification
 * [MONDO:0016343](http://purl.obolibrary.org/obo/MONDO_0016343) unclassified cardiomyopathy --> obsolete unclassified cardiomyopathy
 * [MONDO:0016606](http://purl.obolibrary.org/obo/MONDO_0016606) prenatal benign hypophosphatasia --> obsolete prenatal benign hypophosphatasia
 * [MONDO:0018603](http://purl.obolibrary.org/obo/MONDO_0018603) interstitial lung disease due to SP-c deficiency --> interstitial lung disease due to SP-C deficiency
 * [MONDO:0020720](http://purl.obolibrary.org/obo/MONDO_0020720) X-linked hypophosphatemic rickets (recessive or dominant) --> X-linked hypophosphatemic rickets
 * [MONDO:0023052](http://purl.obolibrary.org/obo/MONDO_0023052) ectrodactyly polydactyly --> obsolete ectrodactyly polydactyly
 * [MONDO:0030965](http://purl.obolibrary.org/obo/MONDO_0030965) olmsted syndrome 2 --> obsolete olmsted syndrome 2
 * [MONDO:0032728](http://purl.obolibrary.org/obo/MONDO_0032728) charcot-marie-tooth disease, axonal, type 2ee --> Charcot-Marie-Tooth disease, axonal, type 2EE

