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metadata
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Date of Raw Data Collection: PPMI (2023-10-01); PDBP (2023-12-04); MGB Biobank (2024-06-21); atccodes (2024-12-01); export_Touchstone (2025-02-07)

Directory of Files: The default path of folders is "~/project/ReRx/". This dataset contains three main folders and included relevant files as shown in the directory below. Note: The raw data are available upon reasonable request, following approval by the MGB Biobank and AMP-PD. All file formats were also included in the directory. No special file naming convention.

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- data
  - raw_data
    - atccodes.csv [ATC codes of medications]
    - export_Touchstone.txt [the list of perturbation-target gene relationship extracted from CMap database]
    - MGB_Biobank [all raw files that were downloaded from databases]
    - PDBP [all raw files that were downloaded from databases]
    - PPMI [all raw files that were downloaded from databases]
  - processed_data
    - drug_dictionary_MGB.csv
    - drug_dictionary_update_PDBP.xlsx
    - drug_dictionary_update_PPMI.xlsx
- results
  - PD_risk_results_AMPPD.xlsx
  - PD_risk_results_MGB.xlsx
  - AMPPD_with_ATC_update.xlsx
  - MGB_with_ATC_update.xlsx
- scripts
  - Characteristic.R
  - Drug_dictionary.R
  - Medication.R
  - PD_progression.R
  - PD_risk.R
  - Replication.R
  - Sensitivity_analysis.R
  - Target_genes.R

- ReRx.txt
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