﻿Supplementary     Table     3:     Fold    changes    and    p-­‐values    for    known    markers    of    colon    stem     cells    and    differentiated    intestinal    tissue.             

Group                Cell    line            Gene    symbol         Log 2     fold    change        BH-­‐adjusted    p-­‐value     Stem    cell               Stem    cell              LRIG1               2.56                2.22E-­‐75                                            TERT                3.46                1.70E-­‐06                                            BMI1                0.29                3.12E-­‐01                                           ASCL2               7.50                1.45E-­‐83                                            LGR5                4.71                1.67E-­‐13                                           OLFM4               0.47                3.28E-­‐01                                            HOPX                -­‐-­‐                    -­‐-­‐    

Differentiated    tissue            Goblet               MUC12               -­‐2.59                1.66E-­‐58    

                                      MUC13               -­‐1.68                2.18E-­‐43                                           MUC4               -­‐1.98                4.01E-­‐24                                           MUC1               -­‐1.51                9.05E-­‐23                                           MUC17               -­‐1.79                4.62E-­‐19                                           MUC20               -­‐1.15                2.99E-­‐17                                           MUC3A               -­‐1.12                1.04E-­‐11                                           ATOH1               2.64                7.39E-­‐08                                            SPN                2.93                2.58E-­‐06                                           MUC2               -­‐1.02                3.29E-­‐04                                          MUC5AC              -­‐1.71                1.36E-­‐02                                           MUC5B               -­‐1.00                6.54E-­‐02                                           CD164               -­‐0.31                2.23E-­‐01                                           MUC16               -­‐0.40                5.98E-­‐01                                           MUC6               0.11                9.12E-­‐01                                           MUC19                -­‐-­‐                    -­‐-­‐                                           MUC7                -­‐-­‐                    -­‐-­‐                                           MUC8                -­‐-­‐                    -­‐-­‐                                           MUC15                -­‐-­‐                    -­‐-­‐                       Enterocyte              FABP2               -­‐1.69                2.91E-­‐19                                           SLC5A1               -­‐1.36                8.00E-­‐16                                             SI                 -­‐1.53                1.20E-­‐06                     Enteroendocrine          NEUROG3              2.24                4.32E-­‐03                                            GAST               -­‐1.03                6.53E-­‐02                                            GCG                1.22                1.83E-­‐01                                            NTS                1.13                2.23E-­‐01                                            SYP                0.47                3.37E-­‐01                                            CHGA               -­‐0.74                3.86E-­‐01                                            CCK                -­‐0.18                8.70E-­‐01                                           FFAR3                -­‐-­‐                    -­‐-­‐                                          NEUROD1               -­‐-­‐                    -­‐-­‐                                            HDC                 -­‐-­‐                    -­‐-­‐                                            SST                 -­‐-­‐                    -­‐-­‐                                            GIP                 -­‐-­‐                    -­‐-­‐                                            SCT                 -­‐-­‐                    -­‐-­‐                                            PYY                 -­‐-­‐                    -­‐-­‐                        Paneth               DEFB1               -­‐1.59                9.29E-­‐15                                            LYZ                1.41                3.77E-­‐14                                            TNF                -­‐2.04                3.18E-­‐12                                           MMP7               0.74                2.20E-­‐04                                           DEFA6               2.28                7.11E-­‐03                                           DEFA5               2.21                7.98E-­‐03                                           DEFB4A               -­‐1.00                1.97E-­‐02                                            ANG                -­‐0.29                1.72E-­‐01                                          DEFB103A               -­‐-­‐                    -­‐-­‐                                          DEFB106A               -­‐-­‐                    -­‐-­‐    

Gene     expression     changes     are     reported     as     Log2     fold-­‐changes     between     untreated     (vehicle)     and     ETC-­‐159    treated    tumors.    BH-­‐adjusted     p-­‐value     refers     to    Benjamini-­‐Hochberg    adjuested    P-­‐values     of     differential     expression     after     correction     of     multiple     testing     (see     also     Supplementary     Table     1).     Missing    values    (indicated    with    “—“)    are    for    those    genes    that    do    not    appear    to    be    expressed    in    the     samples/conditions    assayed.          

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