BY-COVID - WP5 - Baseline Use Case: COVID-19 vaccine effectiveness assessment

Survival analysis

Results

Survival plot

We estimate the survival function using the Kaplan-Meier estimator and represent this function visually using a Kaplan-Meier curve, showing the probability of not getting infected by SARS-CoV-2 at a certain time after onset of follow-up. The survival function is estimated for the control and intervention group.


The cumulative incidence of the event (SARS-CoV-2 infection) was additionally plotted.


Survival (time-to-event)

The probability of not getting infected by SARS-CoV-2 beyond a certain time after onset of follow-up (survival function, estimated using the Kaplan-Meier estimator) is reported for different periods.

Strata Time Number at risk Cumulative sum of number of events Cumulative sum of number censored Survival Std. error Cumulative hazard Std. error cumulative hazard
Not fully vaccinated 0 2123328 0 10 1.0000 0.00000 0.0000 0.00000
Not fully vaccinated 100 518612 53641 1555607 0.9294 0.00031 0.0732 0.00033
Not fully vaccinated 200 56896 164433 1903285 0.5331 0.00109 0.6271 0.00204
Not fully vaccinated 300 11547 179794 1932119 0.3074 0.00164 1.1762 0.00533
Not fully vaccinated 400 2357 182979 1938111 0.2066 0.00192 1.5724 0.00928
Not fully vaccinated 500 62 183141 1940126 0.1468 0.00753 1.9127 0.05097
Fully vaccinated 0 2123328 90 10 1.0000 0.00000 0.0000 0.00000
Fully vaccinated 100 562252 10806 1554040 0.9858 0.00014 0.0143 0.00014
Fully vaccinated 200 108341 49887 1966473 0.8502 0.00071 0.1621 0.00084
Fully vaccinated 300 62020 55931 2005482 0.7898 0.00101 0.2358 0.00127
Fully vaccinated 400 16830 57398 2049932 0.7689 0.00113 0.2626 0.00147
Fully vaccinated 500 393 57466 2065469 0.7513 0.00396 0.2857 0.00526


Median survival time

The median survival time is the time corresponding to a probability of not obtaining a SARS-CoV-2 infection probability of 0.5. (if NA, the probability of not obtaining a SARS-CoV-2 infection did not drop below 50%)

Cox regression and estimation of the average treatment effect

A Cox regression model was built to examine the relationship between the distribution of the probability of not obtaining a SARS-CoV-2 infection (survival distribution) and completing a primary vaccination schedule (covariate). The Cox proportional hazards regression model was fitted with ‘fully_vaccinated_bl’ as a covariate and accounts for clustering within individuals (as one individual can be re-sampled as control).

A hazard ratio (HR) is computed for the covariate ‘fully_vaccinated_bl’. A hazard can be interpreted as the instantaneous rate of SARS-CoV-2 infections in individuals that are at risk for obtaining an infection (Cox proportional hazards regression assumes stable proportional hazards over time). A HR < 1 indicates reduced hazard of SARS-CoV-2 infection when having completed a primary vaccination schedule whereas a HR > 1 indicates an increased hazard of SARS-CoV-2 infection.

Parameter estimate SE coefficient Robust SE coefficient P-value Hazard Ratio (HR) (95% CI for HR)
fully_vaccinated_blTRUE -1.488 0.005 0.005 0 0.226 (0.223, 0.228)

The overall significance of the model is tested.

Test statistic Df P-value
Likelihood ratio test 112825.40 1 0
Wald test 74320.81 1 0
Score (logrank) test 110780.87 1 0
Robust score test 53785.51 1 0

Proportional hazards during the study period might be unlikely. As such, the RMST and RMTL ratios are additionally calculated, providing an alternative estimate for the the Average Treatment Effect (ATE), without requiring the proportional hazards assumption to be met.

Arm Measure Estimate SE CI.lower CI.upper
fully_vaccinated_bl==FALSE RMST 214.444 0.153 214.144 214.745
fully_vaccinated_bl==TRUE RMST 274.070 0.106 273.862 274.278
fully_vaccinated_bl==FALSE RMTL 85.556 0.153 85.255 85.856
fully_vaccinated_bl==TRUE RMTL 25.930 0.106 25.722 26.138
Measure Estimate CI.lower CI.upper p_value
RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 59.626 59.260 59.991 0
RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.278 1.276 1.280 0
RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.303 0.300 0.306 0
Vaccination schedules dropped from the subgroup analysis

Vaccination schedules with less than 500 were dropped from the subgroup analyses.

Vaccination schedule N
JJ-JJ 234
BP-AZ 214
BP-JJ 134
AZ-MD 126
BP-MD 116
AZ-JJ 112
JJ-NV 74
MD-AZ 40
MD-JJ 16
Survival plot

We estimate the survival function using the Kaplan-Meier estimator and represent this function visually using a Kaplan-Meier curve, showing the probability of not getting infected by SARS-CoV-2 at a certain time after onset of follow-up. The survival function is estimated for the control and intervention group, within subsets defined by the vaccination schedule.


The cumulative incidence of the event (SARS-CoV-2 infection) was additionally plotted within subsets defined by the vaccination schedule.


Cox regression and estimation of the average treatment effect

A Cox regression model was built to examine the relationship between the distribution of the probability of not obtaining a SARS-CoV-2 infection (survival distribution) and completing a primary vaccination schedule (covariate), and whether this differs according to the administered vaccination schedule. A stratified Cox proportional hazards regression model was fitted with ‘fully_vaccinated_bl’ as a covariate, ‘vaccination_schedule_cd’ as a stratification factor, and accounting for clustering within individuals (as one individual can be re-sampled as control).

Parameter estimate SE coefficient Robust SE coefficient P-value Hazard Ratio (HR) (95% CI for HR)
fully_vaccinated_blTRUE -1.470 0.014 0.015 0.000 0.23 (0.223, 0.237)
fully_vaccinated_blTRUE:strata(vaccination_schedule_cd)AZ-BP -0.005 0.201 0.196 0.980 0.995 (0.612, 1.378)
fully_vaccinated_blTRUE:strata(vaccination_schedule_cd)BP-BP 0.012 0.015 0.016 0.459 1.012 (0.981, 1.043)
fully_vaccinated_blTRUE:strata(vaccination_schedule_cd)JJ -0.046 0.034 0.036 0.197 0.955 (0.888, 1.022)
fully_vaccinated_blTRUE:strata(vaccination_schedule_cd)JJ-BP -0.737 0.041 0.043 0.000 0.478 (0.438, 0.518)
fully_vaccinated_blTRUE:strata(vaccination_schedule_cd)JJ-MD -0.772 0.073 0.077 0.000 0.462 (0.392, 0.532)
fully_vaccinated_blTRUE:strata(vaccination_schedule_cd)MD-BP -0.177 0.383 0.377 0.639 0.838 (0.219, 1.457)
fully_vaccinated_blTRUE:strata(vaccination_schedule_cd)MD-MD -0.163 0.025 0.026 0.000 0.849 (0.806, 0.892)


The overall significance of the model is tested.

Test statistic Df P-value
Likelihood ratio test 113629.93 8 0
Wald test 74803.89 8 0
Score (logrank) test 111723.32 8 0
Robust score test 55151.09 8 0

Proportional hazards during the study period might be unlikely. As such, the RMST and RMTL ratios are additionally calculated, providing an alternative estimate for the the Average Treatment Effect (ATE), without requiring the proportional hazards assumption to be met.

Vaccination_schedule Arm Measure Estimate SE CI.lower CI.upper
BP-BP fully_vaccinated_bl==FALSE RMST 214.332 0.175 213.990 214.675
BP-BP fully_vaccinated_bl==TRUE RMST 273.340 0.122 273.102 273.578
BP-BP fully_vaccinated_bl==FALSE RMTL 85.668 0.175 85.325 86.010
BP-BP fully_vaccinated_bl==TRUE RMTL 26.660 0.122 26.422 26.898
MD-MD fully_vaccinated_bl==FALSE RMST 224.735 0.565 223.629 225.842
MD-MD fully_vaccinated_bl==TRUE RMST 279.734 0.370 279.008 280.460
MD-MD fully_vaccinated_bl==FALSE RMTL 75.265 0.565 74.158 76.371
MD-MD fully_vaccinated_bl==TRUE RMTL 20.266 0.370 19.540 20.992
MD-BP fully_vaccinated_bl==FALSE RMST 201.068 9.563 182.325 219.811
MD-BP fully_vaccinated_bl==TRUE RMST 266.873 9.419 248.412 285.334
MD-BP fully_vaccinated_bl==FALSE RMTL 98.932 9.563 80.189 117.675
MD-BP fully_vaccinated_bl==TRUE RMTL 33.127 9.419 14.666 51.588
AZ-BP fully_vaccinated_bl==FALSE RMST 197.711 7.590 182.834 212.588
AZ-BP fully_vaccinated_bl==TRUE RMST 260.240 6.925 246.668 273.812
AZ-BP fully_vaccinated_bl==FALSE RMTL 102.289 7.590 87.412 117.166
AZ-BP fully_vaccinated_bl==TRUE RMTL 39.760 6.925 26.188 53.332
AZ-AZ fully_vaccinated_bl==FALSE RMST 211.119 0.572 209.998 212.239
AZ-AZ fully_vaccinated_bl==TRUE RMST 273.696 0.400 272.913 274.479
AZ-AZ fully_vaccinated_bl==FALSE RMTL 88.881 0.572 87.761 90.002
AZ-AZ fully_vaccinated_bl==TRUE RMTL 26.304 0.400 25.521 27.087
JJ-BP fully_vaccinated_bl==FALSE RMST 212.676 0.910 210.892 214.460
JJ-BP fully_vaccinated_bl==TRUE RMST 284.660 0.545 283.592 285.728
JJ-BP fully_vaccinated_bl==FALSE RMTL 87.324 0.910 85.540 89.108
JJ-BP fully_vaccinated_bl==TRUE RMTL 15.340 0.545 14.272 16.408
JJ fully_vaccinated_bl==FALSE RMST 193.990 1.035 191.960 196.019
JJ fully_vaccinated_bl==TRUE RMST 263.583 0.878 261.862 265.304
JJ fully_vaccinated_bl==FALSE RMTL 106.010 1.035 103.981 108.040
JJ fully_vaccinated_bl==TRUE RMTL 36.417 0.878 34.696 38.138
JJ-MD fully_vaccinated_bl==FALSE RMST 193.071 1.818 189.509 196.633
JJ-MD fully_vaccinated_bl==TRUE RMST 280.030 1.259 277.562 282.498
JJ-MD fully_vaccinated_bl==FALSE RMTL 106.929 1.818 103.367 110.491
JJ-MD fully_vaccinated_bl==TRUE RMTL 19.970 1.259 17.502 22.438
Vaccination_schedule Measure Estimate CI.lower CI.upper p_value
BP-BP RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 59.007 58.590 59.424 0
BP-BP RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.275 1.273 1.278 0
BP-BP RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.311 0.308 0.314 0
MD-MD RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 54.999 53.676 56.322 0
MD-MD RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.245 1.238 1.252 0
MD-MD RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.269 0.259 0.280 0
MD-BP RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 65.805 39.497 92.113 0
MD-BP RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.327 1.182 1.491 0
MD-BP RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.335 0.186 0.603 0
AZ-BP RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 62.529 42.391 82.667 0
AZ-BP RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.316 1.201 1.442 0
AZ-BP RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.389 0.268 0.563 0
AZ-AZ RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 62.577 61.210 63.945 0
AZ-AZ RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.296 1.289 1.304 0
AZ-AZ RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.296 0.287 0.306 0
JJ-BP RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 71.985 69.905 74.064 0
JJ-BP RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.338 1.326 1.351 0
JJ-BP RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.176 0.163 0.189 0
JJ RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 69.593 66.932 72.254 0
JJ RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.359 1.342 1.376 0
JJ RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.344 0.326 0.361 0
JJ-MD RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 86.959 82.625 91.293 0
JJ-MD RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.450 1.421 1.480 0
JJ-MD RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.187 0.164 0.212 0
Vaccination schedules dropped from the subgroup analysis

Vaccination schedules with less than 500 were dropped from the subgroup analyses.

Vaccination schedule N
JJ-JJ 234
BP-AZ 214
BP-JJ 134
AZ-MD 126
BP-MD 116
AZ-JJ 112
JJ-NV 74
MD-AZ 40
MD-JJ 16
Survival plot

We estimate the survival function using the Kaplan-Meier estimator and represent this function visually using a Kaplan-Meier curve, showing the probability of not getting infected by SARS-CoV-2 at a certain time after onset of follow-up. The survival function is estimated for the control and intervention group, within subsets defined by the NUTS3 residence area.


The cumulative incidence of the event (SARS-CoV-2 infection) was additionally plotted within subsets defined by the NUTS3 residence area.


Cox regression and estimation of the average treatment effect

A Cox regression model was built to examine the relationship between the distribution of the probability of not obtaining a SARS-CoV-2 infection (survival distribution) and completing a primary vaccination schedule (covariate), and whether this differs according to the area of residence (NUTS3 level). A stratified Cox proportional hazards regression model was fitted with ‘fully_vaccinated_bl’ as a covariate, ‘residence_area_cd’ as a stratification factor, and accounting for clustering within individuals (as one individual can be re-sampled as control).

Parameter estimate SE coefficient Robust SE coefficient P-value Hazard Ratio (HR) (95% CI for HR)
fully_vaccinated_blTRUE -1.593 0.010 0.011 0.000 0.203 (0.199, 0.208)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE310 0.257 0.019 0.021 0.000 1.293 (1.239, 1.347)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE323 0.153 0.023 0.026 0.000 1.165 (1.106, 1.224)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE328 0.189 0.029 0.033 0.000 1.208 (1.131, 1.285)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE329 0.237 0.028 0.032 0.000 1.267 (1.188, 1.346)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE32A 0.154 0.034 0.039 0.000 1.166 (1.078, 1.255)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE32B 0.095 0.020 0.022 0.000 1.1 (1.053, 1.146)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE32C 0.272 0.032 0.037 0.000 1.312 (1.218, 1.406)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE32D 0.250 0.035 0.039 0.000 1.284 (1.185, 1.384)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE331 0.163 0.032 0.036 0.000 1.177 (1.094, 1.26)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE332 0.000 0.017 0.019 1.000 1 (0.963, 1.037)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE334 0.225 0.037 0.042 0.000 1.252 (1.148, 1.355)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE335 -0.112 0.024 0.027 0.000 0.894 (0.847, 0.941)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE336 0.080 0.041 0.046 0.084 1.083 (0.985, 1.181)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE341 0.326 0.063 0.072 0.000 1.385 (1.19, 1.58)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE342 0.155 0.051 0.057 0.007 1.167 (1.036, 1.299)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE343 0.133 0.042 0.048 0.006 1.143 (1.035, 1.251)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE344 0.206 0.040 0.046 0.000 1.229 (1.119, 1.339)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE345 0.336 0.049 0.055 0.000 1.4 (1.249, 1.55)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE351 0.140 0.032 0.037 0.000 1.15 (1.068, 1.232)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE352 0.231 0.022 0.024 0.000 1.26 (1.2, 1.32)
fully_vaccinated_blTRUE:strata(residence_area_cd)BE353 -0.009 0.043 0.048 0.850 0.991 (0.898, 1.084)


The overall significance of the model is tested.

Test statistic Df P-value
Likelihood ratio test 113558.42 22 0
Wald test 74665.04 22 0
Score (logrank) test 111512.35 22 0
Robust score test 54339.47 22 0

Proportional hazards during the study period might be unlikely. As such, the RMST and RMTL ratios are additionally calculated, providing an alternative estimate for the the Average Treatment Effect (ATE), without requiring the proportional hazards assumption to be met.

Residence_area Arm Measure Estimate SE CI.lower CI.upper
BE352 fully_vaccinated_bl==FALSE RMST 219.722 0.613 218.520 220.923
BE352 fully_vaccinated_bl==TRUE RMST 273.419 0.427 272.582 274.255
BE352 fully_vaccinated_bl==FALSE RMTL 80.278 0.613 79.077 81.480
BE352 fully_vaccinated_bl==TRUE RMTL 26.581 0.427 25.745 27.418
BE100 fully_vaccinated_bl==FALSE RMST 209.526 0.318 208.903 210.149
BE100 fully_vaccinated_bl==TRUE RMST 274.509 0.219 274.080 274.937
BE100 fully_vaccinated_bl==FALSE RMTL 90.474 0.318 89.851 91.097
BE100 fully_vaccinated_bl==TRUE RMTL 25.491 0.219 25.063 25.920
BE32D fully_vaccinated_bl==FALSE RMST 214.760 1.078 212.646 216.874
BE32D fully_vaccinated_bl==TRUE RMST 270.540 0.803 268.966 272.113
BE32D fully_vaccinated_bl==FALSE RMTL 85.240 1.078 83.126 87.354
BE32D fully_vaccinated_bl==TRUE RMTL 29.460 0.803 27.887 31.034
BE332 fully_vaccinated_bl==FALSE RMST 208.181 0.430 207.340 209.023
BE332 fully_vaccinated_bl==TRUE RMST 274.616 0.289 274.051 275.182
BE332 fully_vaccinated_bl==FALSE RMTL 91.819 0.430 90.977 92.660
BE332 fully_vaccinated_bl==TRUE RMTL 25.384 0.289 24.818 25.949
BE336 fully_vaccinated_bl==FALSE RMST 214.674 1.179 212.363 216.985
BE336 fully_vaccinated_bl==TRUE RMST 272.822 0.916 271.025 274.618
BE336 fully_vaccinated_bl==FALSE RMTL 85.326 1.179 83.015 87.637
BE336 fully_vaccinated_bl==TRUE RMTL 27.178 0.916 25.382 28.975
BE323 fully_vaccinated_bl==FALSE RMST 223.257 0.626 222.030 224.484
BE323 fully_vaccinated_bl==TRUE RMST 276.216 0.421 275.391 277.041
BE323 fully_vaccinated_bl==FALSE RMTL 76.743 0.626 75.516 77.970
BE323 fully_vaccinated_bl==TRUE RMTL 23.784 0.421 22.959 24.609
BE329 fully_vaccinated_bl==FALSE RMST 213.147 0.858 211.466 214.828
BE329 fully_vaccinated_bl==TRUE RMST 269.934 0.643 268.673 271.195
BE329 fully_vaccinated_bl==FALSE RMTL 86.853 0.858 85.172 88.534
BE329 fully_vaccinated_bl==TRUE RMTL 30.066 0.643 28.805 31.327
BE335 fully_vaccinated_bl==FALSE RMST 213.067 0.626 211.841 214.294
BE335 fully_vaccinated_bl==TRUE RMST 277.722 0.420 276.899 278.544
BE335 fully_vaccinated_bl==FALSE RMTL 86.933 0.626 85.706 88.159
BE335 fully_vaccinated_bl==TRUE RMTL 22.278 0.420 21.456 23.101
BE342 fully_vaccinated_bl==FALSE RMST 218.226 1.567 215.155 221.297
BE342 fully_vaccinated_bl==TRUE RMST 274.592 1.084 272.467 276.717
BE342 fully_vaccinated_bl==FALSE RMTL 81.774 1.567 78.703 84.845
BE342 fully_vaccinated_bl==TRUE RMTL 25.408 1.084 23.283 27.533
BE310 fully_vaccinated_bl==FALSE RMST 216.306 0.541 215.246 217.366
BE310 fully_vaccinated_bl==TRUE RMST 270.968 0.388 270.208 271.729
BE310 fully_vaccinated_bl==FALSE RMTL 83.694 0.541 82.634 84.754
BE310 fully_vaccinated_bl==TRUE RMTL 29.032 0.388 28.271 29.792
BE32B fully_vaccinated_bl==FALSE RMST 212.063 0.527 211.030 213.096
BE32B fully_vaccinated_bl==TRUE RMST 273.283 0.372 272.555 274.011
BE32B fully_vaccinated_bl==FALSE RMTL 87.937 0.527 86.904 88.970
BE32B fully_vaccinated_bl==TRUE RMTL 26.717 0.372 25.989 27.445
BE334 fully_vaccinated_bl==FALSE RMST 206.569 1.266 204.087 209.051
BE334 fully_vaccinated_bl==TRUE RMST 269.225 0.911 267.441 271.010
BE334 fully_vaccinated_bl==FALSE RMTL 93.431 1.266 90.949 95.913
BE334 fully_vaccinated_bl==TRUE RMTL 30.775 0.911 28.990 32.559
BE344 fully_vaccinated_bl==FALSE RMST 214.899 1.243 212.463 217.336
BE344 fully_vaccinated_bl==TRUE RMST 271.052 0.929 269.232 272.873
BE344 fully_vaccinated_bl==FALSE RMTL 85.101 1.243 82.664 87.537
BE344 fully_vaccinated_bl==TRUE RMTL 28.948 0.929 27.127 30.768
BE32A fully_vaccinated_bl==FALSE RMST 225.908 1.002 223.943 227.872
BE32A fully_vaccinated_bl==TRUE RMST 278.244 0.627 277.016 279.473
BE32A fully_vaccinated_bl==FALSE RMTL 74.092 1.002 72.128 76.057
BE32A fully_vaccinated_bl==TRUE RMTL 21.756 0.627 20.527 22.984
BE331 fully_vaccinated_bl==FALSE RMST 210.746 1.008 208.770 212.723
BE331 fully_vaccinated_bl==TRUE RMST 271.653 0.714 270.253 273.053
BE331 fully_vaccinated_bl==FALSE RMTL 89.254 1.008 87.277 91.230
BE331 fully_vaccinated_bl==TRUE RMTL 28.347 0.714 26.947 29.747
BE351 fully_vaccinated_bl==FALSE RMST 214.891 0.959 213.010 216.771
BE351 fully_vaccinated_bl==TRUE RMST 273.355 0.689 272.006 274.704
BE351 fully_vaccinated_bl==FALSE RMTL 85.109 0.959 83.229 86.990
BE351 fully_vaccinated_bl==TRUE RMTL 26.645 0.689 25.296 27.994
BE328 fully_vaccinated_bl==FALSE RMST 228.759 0.791 227.209 230.309
BE328 fully_vaccinated_bl==TRUE RMST 277.832 0.515 276.822 278.842
BE328 fully_vaccinated_bl==FALSE RMTL 71.241 0.791 69.691 72.791
BE328 fully_vaccinated_bl==TRUE RMTL 22.168 0.515 21.158 23.178
BE32C fully_vaccinated_bl==FALSE RMST 217.337 1.004 215.370 219.304
BE32C fully_vaccinated_bl==TRUE RMST 270.571 0.740 269.121 272.022
BE32C fully_vaccinated_bl==FALSE RMTL 82.663 1.004 80.696 84.630
BE32C fully_vaccinated_bl==TRUE RMTL 29.429 0.740 27.978 30.879
BE353 fully_vaccinated_bl==FALSE RMST 214.076 1.213 211.699 216.453
BE353 fully_vaccinated_bl==TRUE RMST 275.537 0.862 273.848 277.227
BE353 fully_vaccinated_bl==FALSE RMTL 85.924 1.213 83.547 88.301
BE353 fully_vaccinated_bl==TRUE RMTL 24.463 0.862 22.773 26.152
BE345 fully_vaccinated_bl==FALSE RMST 221.169 1.507 218.215 224.123
BE345 fully_vaccinated_bl==TRUE RMST 271.008 1.128 268.797 273.220
BE345 fully_vaccinated_bl==FALSE RMTL 78.831 1.507 75.877 81.785
BE345 fully_vaccinated_bl==TRUE RMTL 28.992 1.128 26.780 31.203
BE343 fully_vaccinated_bl==FALSE RMST 211.807 1.343 209.174 214.440
BE343 fully_vaccinated_bl==TRUE RMST 272.501 0.966 270.608 274.394
BE343 fully_vaccinated_bl==FALSE RMTL 88.193 1.343 85.560 90.826
BE343 fully_vaccinated_bl==TRUE RMTL 27.499 0.966 25.606 29.392
BE341 fully_vaccinated_bl==FALSE RMST 231.848 1.784 228.352 235.345
BE341 fully_vaccinated_bl==TRUE RMST 276.681 1.261 274.209 279.152
BE341 fully_vaccinated_bl==FALSE RMTL 68.152 1.784 64.655 71.648
BE341 fully_vaccinated_bl==TRUE RMTL 23.319 1.261 20.848 25.791
Residence_area Measure Estimate CI.lower CI.upper p_value
BE352 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 53.697 52.234 55.161 0
BE352 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.244 1.237 1.252 0
BE352 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.331 0.320 0.343 0
BE100 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 64.983 64.227 65.739 0
BE100 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.310 1.306 1.315 0
BE100 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.282 0.277 0.287 0
BE32D RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 55.780 53.145 58.415 0
BE32D RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.260 1.245 1.274 0
BE32D RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.346 0.326 0.367 0
BE332 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 66.435 65.421 67.449 0
BE332 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.319 1.313 1.325 0
BE332 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.276 0.270 0.283 0
BE336 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 58.148 55.221 61.074 0
BE336 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.271 1.255 1.287 0
BE336 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.319 0.297 0.342 0
BE323 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 52.959 51.481 54.438 0
BE323 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.237 1.229 1.245 0
BE323 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.310 0.298 0.322 0
BE329 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 56.786 54.685 58.888 0
BE329 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.266 1.255 1.278 0
BE329 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.346 0.331 0.363 0
BE335 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 64.654 63.178 66.131 0
BE335 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.303 1.295 1.312 0
BE335 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.256 0.246 0.267 0
BE342 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 56.367 52.632 60.101 0
BE342 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.258 1.238 1.279 0
BE342 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.311 0.283 0.341 0
BE310 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 54.662 53.358 55.966 0
BE310 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.253 1.246 1.260 0
BE310 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.347 0.337 0.357 0
BE32B RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 61.220 59.956 62.484 0
BE32B RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.289 1.282 1.296 0
BE32B RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.304 0.295 0.313 0
BE334 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 62.656 59.599 65.713 0
BE334 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.303 1.286 1.321 0
BE334 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.329 0.309 0.351 0
BE344 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 56.153 53.111 59.195 0
BE344 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.261 1.245 1.278 0
BE344 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.340 0.317 0.364 0
BE32A RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 52.337 50.020 54.654 0
BE32A RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.232 1.220 1.244 0
BE32A RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.294 0.276 0.313 0
BE331 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 60.907 58.485 63.329 0
BE331 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.289 1.275 1.303 0
BE331 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.318 0.301 0.335 0
BE351 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 58.464 56.150 60.779 0
BE351 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.272 1.259 1.285 0
BE351 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.313 0.296 0.331 0
BE328 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 49.073 47.223 50.923 0
BE328 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.215 1.205 1.224 0
BE328 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.311 0.296 0.327 0
BE32C RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 53.234 50.790 55.678 0
BE32C RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.245 1.232 1.258 0
BE32C RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.356 0.337 0.376 0
BE353 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 61.462 58.545 64.378 0
BE353 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.287 1.271 1.304 0
BE353 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.285 0.264 0.307 0
BE345 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 49.839 46.149 53.530 0
BE345 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.225 1.206 1.245 0
BE345 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.368 0.338 0.400 0
BE343 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 60.694 57.451 63.937 0
BE343 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.287 1.268 1.305 0
BE343 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.312 0.289 0.336 0
BE341 RMST (fully_vaccinated_bl==TRUE)-(fully_vaccinated_bl==FALSE) 44.832 40.550 49.114 0
BE341 RMST (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 1.193 1.173 1.214 0
BE341 RMTL (fully_vaccinated_bl==TRUE)/(fully_vaccinated_bl==FALSE) 0.342 0.304 0.385 0