We present the case of a 62-year-old female patient who underwent surgery in December 2010 for papillary serous carcinoma of the left ovary with involvement of a lymph node of the aorto-caval chain (stage IIIC). She subsequently received adjuvant chemotherapy with carboplatin and paclitaxel, ending in June 2011. Later, she started follow-up and remained asymptomatic until April 2013, when a CA 125 elevation of 88.4 U/ml (0-35 U/ml) was detected. A CT scan showed an image adjacent to the colon and she underwent anterior resection of the upper rectum with intraoperative biopsy of a liver lesion which confirmed the metastatic nature.
A second line of treatment with carboplatin and paclitaxel was started, showing a CA 125 value of 123.3 U/ml. After a first cycle with good tolerance, we scheduled the second cycle and during the first few minutes of the carboplatin infusion, he presented a sudden onset of dyspnoea, vomiting, loss of consciousness and an SAC/TAD of 70/50 mmHg. The infusion was stopped and after the administration of corticosteroids the symptoms began to subside. The Allergology Unit recommended a desensitisation5 scheme with slowing of the infusion rate. For this purpose, three solutions were used with concentrations of 0.02, 0.2 and 2 mg/ml respectively, in addition to premedication the night before and half an hour before the infusion with:
- Cetirizine 10 mg - Prednisone 1 mg/kg - Ranitidine 150 mg - Montelukast 10 mg
Despite this, a few minutes later, he began with dyspnoea, sweating and blood pressure of 85/60 mmHg, forcing the infusion to be stopped and recommending no further use of any platinum salt.
In September 2013, it was decided to start 3rd line chemotherapy with trabectedin and pegylated liposomal adriamycin. After the third cycle, the markers normalised and she completed the sixth cycle, and is currently disease-free.

