This is a data dictionary for the cleaned virology data for the molnupiravir study in the PANORAMIC trial.
File: panoramic_virology_molnupiravir_230927.csv
| variable_name | description | values |
|---|---|---|
| id | nlmixr2 reserved term, numerical ID number | numeric |
| t_start_therapy | Day since start of treatment | numeric |
| t_symp_days | Days since symptom onset | numeric |
| t_symp_enrol | Days since symptom onset at enrolment | numeric |
| time | nlmixr2 reserved term, time starting from 0 in days | numeric |
| dv | nlmixr2 reserved term - dependent variable, is Log10 vl with cens=1 set to loq rather than loq/2 and antispike antibody - see dvid | numeric |
| cens | nlmixr2 reserved term bloq_1 Flag for below quantification limit of 109 cp/mL | binary 1=TRUE |
| evid | nlmixr2 reserved term | 0=observation 1=dose 2=prediction |
| dvid | nlmixr2 reserved term indicates whether dv is virus or antibody | character |
| sample_group | Intensive or less intensive | character |
| treat_group | Allocation | character |
| age_y | Age in years | numeric |
| sex_male | male or female | 1 = male, 0 = female, NA = unknown |
| num_doses | Number of days reported taking molnupiravir doses | numeric 0-5 days |
| drug_eff | Fractional drug effect, num_doses / 5, used as indicator in as-treated analysis | Fraction |
| crp | CRP as covariate with values carried forward, missing imputed to median for day | numeric |
| anti_spk_dil_log10 | log10 s-antibody as covariate, missing imputed to median for day | numeric |
| day | study day | text |
| day_group | study day grouped for day 5+/-1 or 14 +/-1. For intensive patients chose the Day 4-6 sample corresponding with day antibodies measured | text |
| bl_virus | baseline log10 viral load, missing (n=6) imputed to median | numeric |
| bl_antibody | baseline log10 s-antibody, missing (n=28) imputed to median | numeric |
| persister | Was viral load above LOQ at day >12? | 1 = yes, 0 = no |
| n_vacccine | Number of vaccine doses | integer, -99 missing |
| mutation_load | Number of mutations in virus compared with reference genome | numeric, -999 not sequenced |
| transition | Number of transition mutations in virus compared with reference genome | numeric, -999 not sequenced |
| transversion | Number of transversion mutations in virus compared with reference genome | numeric, -999 not sequenced |
| spike | Number of spike mutations compared with reference genome | numeric, -999 not sequenced |
| spike_escape | Number of spike escape mutations compared with reference genome | numeric, -999 not sequenced |
| culture_positive | Whether virus was cultured | binary, 1=yes, 0 = no, -999 not tested |