data_7MB7
# 
_entry.id   7MB7 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.359 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7MB7         pdb_00007mb7 10.2210/pdb7mb7/pdb 
WWPDB D_1000255813 ?            ?                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        7MB7 
_pdbx_database_status.recvd_initial_deposition_date   2021-03-31 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Lockbaum, G.J.' 1 0000-0003-2720-6984 
'Schiffer, C.A.' 2 0000-0003-2270-6613 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'SARS-CoV-2 Main Protease (Mpro) C145A in Complex with Cleavage Site Nsp7/8 (P6-P1)' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Lockbaum, G.J.' 1 0000-0003-2720-6984 
primary 'Schiffer, C.A.' 2 0000-0003-2270-6613 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   114.470 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     7MB7 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     99.437 
_cell.length_a_esd                 ? 
_cell.length_b                     79.399 
_cell.length_b_esd                 ? 
_cell.length_c                     52.099 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
# 
_symmetry.entry_id                         7MB7 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man '3C-like proteinase'    33793.480 1   3.4.22.69 C145A ? ?                              
2 polymer man ASN-ARG-ALA-THR-LEU-GLN 702.780   1   ?         ?     ? 'Cleavage Site Nsp7/8 (P6-P1)' 
3 water   nat water                   18.015    141 ?         ?     ? ?                              
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSAGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSAGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
A ? 
2 'polypeptide(L)' no no NRATLQ NRATLQ B ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  LEU n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 ALA n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
2 1   ASN n 
2 2   ARG n 
2 3   ALA n 
2 4   THR n 
2 5   LEU n 
2 6   GLN n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 306 '2019-nCoV, SARS-CoV-2' ? 'rep, 1a-1b' ? ? ? ? ? ? 
'Severe acute respiratory syndrome coronavirus 2' 2697049 ? ? ? ? ? ? ? ? 'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
? ? ? ? 
2 1 sample 'Biological sequence' 1 6   '2019-nCoV, SARS-CoV-2' ? 'rep, 1a-1b' ? ? ? ? ? ? 
'Severe acute respiratory syndrome coronavirus 2' 2697049 ? ? ? ? ? ? ? ? 'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
? ? ? ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP R1AB_SARS2 P0DTD1 ? 1 
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
3264 
2 UNP R1AB_SARS2 P0DTD1 ? 2 NRATLQ 3937 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 7MB7 A 1 ? 306 ? P0DTD1 3264 ? 3569 ? 1  306 
2 2 7MB7 B 1 ? 6   ? P0DTD1 3937 ? 3942 ? -6 -1  
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             7MB7 
_struct_ref_seq_dif.mon_id                       ALA 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      145 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P0DTD1 
_struct_ref_seq_dif.db_mon_id                    CYS 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          3408 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            145 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   7MB7 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                      ? 
_exptl_crystal.density_diffrn              ? 
_exptl_crystal.density_Matthews            2.71 
_exptl_crystal.density_method              ? 
_exptl_crystal.density_percent_sol         54.67 
_exptl_crystal.description                 ? 
_exptl_crystal.F_000                       ? 
_exptl_crystal.id                          1 
_exptl_crystal.preparation                 ? 
_exptl_crystal.size_max                    ? 
_exptl_crystal.size_mid                    ? 
_exptl_crystal.size_min                    ? 
_exptl_crystal.size_rad                    ? 
_exptl_crystal.colour_lustre               ? 
_exptl_crystal.colour_modifier             ? 
_exptl_crystal.colour_primary              ? 
_exptl_crystal.density_meas                ? 
_exptl_crystal.density_meas_esd            ? 
_exptl_crystal.density_meas_gt             ? 
_exptl_crystal.density_meas_lt             ? 
_exptl_crystal.density_meas_temp           ? 
_exptl_crystal.density_meas_temp_esd       ? 
_exptl_crystal.density_meas_temp_gt        ? 
_exptl_crystal.density_meas_temp_lt        ? 
_exptl_crystal.pdbx_crystal_image_url      ? 
_exptl_crystal.pdbx_crystal_image_format   ? 
_exptl_crystal.pdbx_mosaicity              ? 
_exptl_crystal.pdbx_mosaicity_esd          ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp            293 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '18% PEG 3350, 0.1M Bis-Tris-Methane:HCl pH 5.5, 0.2M NaCl' 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-03-02 
_diffrn_detector.pdbx_frequency               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979356 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979356 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-2 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          39.680 
_reflns.entry_id                                       7MB7 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.02 
_reflns.d_resolution_low                               29.840 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     23874 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.3 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                2.0 
_reflns.pdbx_Rmerge_I_obs                              0.033 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          10.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.02 
_reflns_shell.d_res_low                                     2.09 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.9 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2236 
_reflns_shell.percent_possible_all                          93.0 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.295 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               1.9 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.882 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                154.770 
_refine.B_iso_mean                               54.9371 
_refine.B_iso_min                                27.210 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 7MB7 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.0200 
_refine.ls_d_res_low                             29.8400 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     23848 
_refine.ls_number_reflns_R_free                  1193 
_refine.ls_number_reflns_R_work                  22655 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.0100 
_refine.ls_percent_reflns_R_free                 5.0000 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1918 
_refine.ls_R_factor_R_free                       0.2241 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1901 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.400 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      7L0D 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 28.4700 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2400 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         final 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.0200 
_refine_hist.d_res_low                        29.8400 
_refine_hist.number_atoms_solvent             141 
_refine_hist.number_atoms_total               2483 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       308 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          51.49 
_refine_hist.pdbx_number_atoms_protein        2342 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
'X-RAY DIFFRACTION' 2.0200 2.1000  2433 . 122 2311 91.0000  . . . 0.3458 0.0000 0.3025 . . . . . . . 9 . . . 
'X-RAY DIFFRACTION' 2.1000 2.1900  2666 . 133 2533 98.0000  . . . 0.2688 0.0000 0.2635 . . . . . . . 9 . . . 
'X-RAY DIFFRACTION' 2.1900 2.3100  2610 . 132 2478 98.0000  . . . 0.3060 0.0000 0.2407 . . . . . . . 9 . . . 
'X-RAY DIFFRACTION' 2.3100 2.4500  2681 . 134 2547 99.0000  . . . 0.2835 0.0000 0.2155 . . . . . . . 9 . . . 
'X-RAY DIFFRACTION' 2.4500 2.6400  2668 . 133 2535 99.0000  . . . 0.2518 0.0000 0.2130 . . . . . . . 9 . . . 
'X-RAY DIFFRACTION' 2.6400 2.9100  2662 . 132 2530 99.0000  . . . 0.2596 0.0000 0.2217 . . . . . . . 9 . . . 
'X-RAY DIFFRACTION' 2.9100 3.3300  2674 . 134 2540 99.0000  . . . 0.2842 0.0000 0.2125 . . . . . . . 9 . . . 
'X-RAY DIFFRACTION' 3.3300 4.1900  2707 . 135 2572 99.0000  . . . 0.2164 0.0000 0.1721 . . . . . . . 9 . . . 
'X-RAY DIFFRACTION' 4.1900 29.8400 2747 . 138 2609 100.0000 . . . 0.1604 0.0000 0.1538 . . . . . . . 9 . . . 
# 
_struct.entry_id                     7MB7 
_struct.title                        'SARS-CoV-2 Main Protease (Mpro) C145A in Complex with Cleavage Site Nsp7/8 (P6-P1)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        7MB7 
_struct_keywords.text            
;SARS-CoV-2, COVID-19, COVID19 PROTEASE, PROTEASE INHIBITOR, COMPLEX, HYDROLASE INHIBITOR COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
;
_struct_keywords.pdbx_keywords   'HYDROLASE/HYDROLASE INHIBITOR' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P4  AA4 SER A 62  ? HIS A 64  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P5  AA5 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P6  AA6 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P7  AA7 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P8  AA8 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P9  AA9 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P10 AB1 THR A 292 ? CYS A 300 ? THR A 292 CYS A 300 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 3 ? 
AA3 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
AA3 1 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 2 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA3 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA3 4 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 5 THR B 4   ? LEU B 5   ? THR B -3  LEU B -2  
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O LEU A 75  ? O LEU A 75  N VAL A 68  ? N VAL A 68  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O VAL A 86  ? O VAL A 86  N GLN A 83  ? N GLN A 83  
AA2 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA2 2 3 N MET A 162 ? N MET A 162 O THR A 175 ? O THR A 175 
AA3 1 2 O TYR A 126 ? O TYR A 126 N VAL A 114 ? N VAL A 114 
AA3 2 3 N SER A 113 ? N SER A 113 O PHE A 150 ? O PHE A 150 
AA3 3 4 N ASN A 151 ? N ASN A 151 O SER A 158 ? O SER A 158 
AA3 4 5 N GLU A 166 ? N GLU A 166 O THR B 4   ? O THR B -3  
# 
_atom_sites.entry_id                    7MB7 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.fract_transf_matrix[1][1]   0.010057 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.004577 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012595 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.021089 
_atom_sites.fract_transf_vector[1]      0.000000 
_atom_sites.fract_transf_vector[2]      0.000000 
_atom_sites.fract_transf_vector[3]      0.000000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
H 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . SER A 1 1   ? -10.383 8.564   -13.238 1.00 45.27  ? 1   SER A N    1 
ATOM   2    C CA   . SER A 1 1   ? -10.385 7.401   -12.301 1.00 35.89  ? 1   SER A CA   1 
ATOM   3    C C    . SER A 1 1   ? -9.033  7.290   -11.606 1.00 42.40  ? 1   SER A C    1 
ATOM   4    O O    . SER A 1 1   ? -8.179  8.167   -11.746 1.00 38.91  ? 1   SER A O    1 
ATOM   5    C CB   . SER A 1 1   ? -10.712 6.109   -13.047 1.00 47.59  ? 1   SER A CB   1 
ATOM   6    O OG   . SER A 1 1   ? -9.638  5.718   -13.884 1.00 56.32  ? 1   SER A OG   1 
ATOM   7    H H1   . SER A 1 1   ? -11.152 9.006   -13.162 1.00 54.38  ? 1   SER A H1   1 
ATOM   8    H H2   . SER A 1 1   ? -9.707  9.106   -13.036 1.00 54.38  ? 1   SER A H2   1 
ATOM   9    H H3   . SER A 1 1   ? -10.290 8.271   -14.073 1.00 54.38  ? 1   SER A H3   1 
ATOM   10   H HA   . SER A 1 1   ? -11.070 7.525   -11.625 1.00 43.13  ? 1   SER A HA   1 
ATOM   11   H HB2  . SER A 1 1   ? -10.879 5.406   -12.400 1.00 57.16  ? 1   SER A HB2  1 
ATOM   12   H HB3  . SER A 1 1   ? -11.501 6.252   -13.593 1.00 57.16  ? 1   SER A HB3  1 
ATOM   13   H HG   . SER A 1 1   ? -9.845  5.026   -14.313 1.00 67.64  ? 1   SER A HG   1 
ATOM   14   N N    . GLY A 1 2   ? -8.844  6.204   -10.874 1.00 37.47  ? 2   GLY A N    1 
ATOM   15   C CA   . GLY A 1 2   ? -7.697  6.052   -10.005 1.00 41.91  ? 2   GLY A CA   1 
ATOM   16   C C    . GLY A 1 2   ? -8.035  6.438   -8.577  1.00 40.26  ? 2   GLY A C    1 
ATOM   17   O O    . GLY A 1 2   ? -8.926  7.255   -8.318  1.00 50.42  ? 2   GLY A O    1 
ATOM   18   H H    . GLY A 1 2   ? -9.378  5.530   -10.865 1.00 45.02  ? 2   GLY A H    1 
ATOM   19   H HA2  . GLY A 1 2   ? -7.401  5.129   -10.015 1.00 50.35  ? 2   GLY A HA2  1 
ATOM   20   H HA3  . GLY A 1 2   ? -6.974  6.619   -10.317 1.00 50.35  ? 2   GLY A HA3  1 
ATOM   21   N N    . PHE A 1 3   ? -7.320  5.838   -7.626  1.00 45.11  ? 3   PHE A N    1 
ATOM   22   C CA   . PHE A 1 3   ? -7.570  6.106   -6.212  1.00 38.08  ? 3   PHE A CA   1 
ATOM   23   C C    . PHE A 1 3   ? -6.244  6.161   -5.474  1.00 48.23  ? 3   PHE A C    1 
ATOM   24   O O    . PHE A 1 3   ? -5.474  5.197   -5.503  1.00 48.69  ? 3   PHE A O    1 
ATOM   25   C CB   . PHE A 1 3   ? -8.487  5.047   -5.594  1.00 41.07  ? 3   PHE A CB   1 
ATOM   26   C CG   . PHE A 1 3   ? -9.165  5.502   -4.330  1.00 40.95  ? 3   PHE A CG   1 
ATOM   27   C CD1  . PHE A 1 3   ? -10.185 6.435   -4.372  1.00 48.32  ? 3   PHE A CD1  1 
ATOM   28   C CD2  . PHE A 1 3   ? -8.774  5.004   -3.098  1.00 37.02  ? 3   PHE A CD2  1 
ATOM   29   C CE1  . PHE A 1 3   ? -10.806 6.859   -3.208  1.00 46.66  ? 3   PHE A CE1  1 
ATOM   30   C CE2  . PHE A 1 3   ? -9.393  5.423   -1.935  1.00 43.04  ? 3   PHE A CE2  1 
ATOM   31   C CZ   . PHE A 1 3   ? -10.411 6.352   -1.991  1.00 36.20  ? 3   PHE A CZ   1 
ATOM   32   H H    . PHE A 1 3   ? -6.687  5.275   -7.775  1.00 54.18  ? 3   PHE A H    1 
ATOM   33   H HA   . PHE A 1 3   ? -8.000  6.971   -6.125  1.00 45.75  ? 3   PHE A HA   1 
ATOM   34   H HB2  . PHE A 1 3   ? -9.178  4.819   -6.236  1.00 49.34  ? 3   PHE A HB2  1 
ATOM   35   H HB3  . PHE A 1 3   ? -7.959  4.262   -5.381  1.00 49.34  ? 3   PHE A HB3  1 
ATOM   36   H HD1  . PHE A 1 3   ? -10.458 6.782   -5.191  1.00 58.05  ? 3   PHE A HD1  1 
ATOM   37   H HD2  . PHE A 1 3   ? -8.086  4.379   -3.053  1.00 44.49  ? 3   PHE A HD2  1 
ATOM   38   H HE1  . PHE A 1 3   ? -11.490 7.487   -3.249  1.00 56.05  ? 3   PHE A HE1  1 
ATOM   39   H HE2  . PHE A 1 3   ? -9.122  5.079   -1.114  1.00 51.70  ? 3   PHE A HE2  1 
ATOM   40   H HZ   . PHE A 1 3   ? -10.829 6.635   -1.210  1.00 43.49  ? 3   PHE A HZ   1 
ATOM   41   N N    . ARG A 1 4   ? -5.994  7.274   -4.790  1.00 41.84  ? 4   ARG A N    1 
ATOM   42   C CA   . ARG A 1 4   ? -4.722  7.500   -4.126  1.00 39.32  ? 4   ARG A CA   1 
ATOM   43   C C    . ARG A 1 4   ? -4.961  8.058   -2.731  1.00 48.73  ? 4   ARG A C    1 
ATOM   44   O O    . ARG A 1 4   ? -5.954  8.746   -2.480  1.00 38.80  ? 4   ARG A O    1 
ATOM   45   C CB   . ARG A 1 4   ? -3.847  8.465   -4.944  1.00 41.48  ? 4   ARG A CB   1 
ATOM   46   C CG   . ARG A 1 4   ? -3.098  7.805   -6.096  1.00 47.95  ? 4   ARG A CG   1 
ATOM   47   C CD   . ARG A 1 4   ? -1.629  7.599   -5.751  1.00 52.97  ? 4   ARG A CD   1 
ATOM   48   N NE   . ARG A 1 4   ? -0.835  7.168   -6.896  1.00 57.29  ? 4   ARG A NE   1 
ATOM   49   C CZ   . ARG A 1 4   ? 0.419   6.744   -6.820  1.00 64.55  ? 4   ARG A CZ   1 
ATOM   50   N NH1  . ARG A 1 4   ? 1.065   6.701   -5.666  1.00 74.13  ? 4   ARG A NH1  1 
ATOM   51   N NH2  . ARG A 1 4   ? 1.040   6.348   -7.929  1.00 48.24  ? 4   ARG A NH2  1 
ATOM   52   H H    . ARG A 1 4   ? -6.556  7.918   -4.697  1.00 50.27  ? 4   ARG A H    1 
ATOM   53   H HA   . ARG A 1 4   ? -4.248  6.660   -4.022  1.00 47.24  ? 4   ARG A HA   1 
ATOM   54   H HB2  . ARG A 1 4   ? -4.415  9.156   -5.320  1.00 49.83  ? 4   ARG A HB2  1 
ATOM   55   H HB3  . ARG A 1 4   ? -3.188  8.862   -4.354  1.00 49.83  ? 4   ARG A HB3  1 
ATOM   56   H HG2  . ARG A 1 4   ? -3.492  6.939   -6.284  1.00 57.60  ? 4   ARG A HG2  1 
ATOM   57   H HG3  . ARG A 1 4   ? -3.151  8.371   -6.882  1.00 57.60  ? 4   ARG A HG3  1 
ATOM   58   H HD2  . ARG A 1 4   ? -1.259  8.435   -5.428  1.00 63.62  ? 4   ARG A HD2  1 
ATOM   59   H HD3  . ARG A 1 4   ? -1.558  6.917   -5.064  1.00 63.62  ? 4   ARG A HD3  1 
ATOM   60   H HE   . ARG A 1 4   ? -1.204  7.191   -7.672  1.00 68.80  ? 4   ARG A HE   1 
ATOM   61   H HH11 . ARG A 1 4   ? 0.671   6.953   -4.944  1.00 89.01  ? 4   ARG A HH11 1 
ATOM   62   H HH12 . ARG A 1 4   ? 1.878   6.423   -5.639  1.00 89.01  ? 4   ARG A HH12 1 
ATOM   63   H HH21 . ARG A 1 4   ? 0.627   6.370   -8.683  1.00 57.94  ? 4   ARG A HH21 1 
ATOM   64   H HH22 . ARG A 1 4   ? 1.853   6.071   -7.891  1.00 57.94  ? 4   ARG A HH22 1 
ATOM   65   N N    . LYS A 1 5   ? -4.049  7.732   -1.814  1.00 47.93  ? 5   LYS A N    1 
ATOM   66   C CA   . LYS A 1 5   ? -4.025  8.421   -0.528  1.00 40.26  ? 5   LYS A CA   1 
ATOM   67   C C    . LYS A 1 5   ? -3.786  9.894   -0.831  1.00 35.12  ? 5   LYS A C    1 
ATOM   68   O O    . LYS A 1 5   ? -2.712  10.269  -1.314  1.00 46.38  ? 5   LYS A O    1 
ATOM   69   C CB   . LYS A 1 5   ? -2.963  7.854   0.402   1.00 48.89  ? 5   LYS A CB   1 
ATOM   70   C CG   . LYS A 1 5   ? -3.492  6.697   1.244   1.00 61.38  ? 5   LYS A CG   1 
ATOM   71   C CD   . LYS A 1 5   ? -3.208  6.875   2.727   1.00 56.92  ? 5   LYS A CD   1 
ATOM   72   C CE   . LYS A 1 5   ? -3.583  5.614   3.496   1.00 61.03  ? 5   LYS A CE   1 
ATOM   73   N NZ   . LYS A 1 5   ? -2.852  4.412   2.996   1.00 70.28  ? 5   LYS A NZ   1 
ATOM   74   H H    . LYS A 1 5   ? -3.446  7.127   -1.912  1.00 57.58  ? 5   LYS A H    1 
ATOM   75   H HA   . LYS A 1 5   ? -4.859  8.303   -0.047  1.00 48.36  ? 5   LYS A HA   1 
ATOM   76   H HB2  . LYS A 1 5   ? -2.219  7.527   -0.128  1.00 58.73  ? 5   LYS A HB2  1 
ATOM   77   H HB3  . LYS A 1 5   ? -2.661  8.553   1.002   1.00 58.73  ? 5   LYS A HB3  1 
ATOM   78   H HG2  . LYS A 1 5   ? -4.453  6.635   1.128   1.00 73.71  ? 5   LYS A HG2  1 
ATOM   79   H HG3  . LYS A 1 5   ? -3.068  5.874   0.954   1.00 73.71  ? 5   LYS A HG3  1 
ATOM   80   H HD2  . LYS A 1 5   ? -2.263  7.048   2.859   1.00 68.36  ? 5   LYS A HD2  1 
ATOM   81   H HD3  . LYS A 1 5   ? -3.732  7.615   3.072   1.00 68.36  ? 5   LYS A HD3  1 
ATOM   82   H HE2  . LYS A 1 5   ? -3.363  5.734   4.433   1.00 73.30  ? 5   LYS A HE2  1 
ATOM   83   H HE3  . LYS A 1 5   ? -4.535  5.451   3.398   1.00 73.30  ? 5   LYS A HE3  1 
ATOM   84   H HZ1  . LYS A 1 5   ? -3.150  4.189   2.187   1.00 84.40  ? 5   LYS A HZ1  1 
ATOM   85   H HZ2  . LYS A 1 5   ? -1.981  4.585   2.945   1.00 84.40  ? 5   LYS A HZ2  1 
ATOM   86   H HZ3  . LYS A 1 5   ? -2.978  3.727   3.549   1.00 84.40  ? 5   LYS A HZ3  1 
ATOM   87   N N    . MET A 1 6   ? -4.786  10.731  -0.579  1.00 36.34  ? 6   MET A N    1 
ATOM   88   C CA   . MET A 1 6   ? -4.803  12.099  -1.073  1.00 41.39  ? 6   MET A CA   1 
ATOM   89   C C    . MET A 1 6   ? -4.959  13.067  0.086   1.00 39.89  ? 6   MET A C    1 
ATOM   90   O O    . MET A 1 6   ? -5.892  12.942  0.887   1.00 41.61  ? 6   MET A O    1 
ATOM   91   C CB   . MET A 1 6   ? -5.936  12.284  -2.080  1.00 37.92  ? 6   MET A CB   1 
ATOM   92   C CG   . MET A 1 6   ? -5.996  13.659  -2.700  1.00 46.61  ? 6   MET A CG   1 
ATOM   93   S SD   . MET A 1 6   ? -6.941  13.661  -4.233  1.00 47.92  ? 6   MET A SD   1 
ATOM   94   C CE   . MET A 1 6   ? -8.604  13.935  -3.621  1.00 50.46  ? 6   MET A CE   1 
ATOM   95   H H    . MET A 1 6   ? -5.479  10.524  -0.115  1.00 43.66  ? 6   MET A H    1 
ATOM   96   H HA   . MET A 1 6   ? -3.961  12.291  -1.515  1.00 49.72  ? 6   MET A HA   1 
ATOM   97   H HB2  . MET A 1 6   ? -5.819  11.642  -2.799  1.00 45.56  ? 6   MET A HB2  1 
ATOM   98   H HB3  . MET A 1 6   ? -6.780  12.127  -1.629  1.00 45.56  ? 6   MET A HB3  1 
ATOM   99   H HG2  . MET A 1 6   ? -6.422  14.271  -2.079  1.00 55.99  ? 6   MET A HG2  1 
ATOM   100  H HG3  . MET A 1 6   ? -5.096  13.960  -2.897  1.00 55.99  ? 6   MET A HG3  1 
ATOM   101  H HE1  . MET A 1 6   ? -9.219  13.944  -4.371  1.00 60.61  ? 6   MET A HE1  1 
ATOM   102  H HE2  . MET A 1 6   ? -8.838  13.219  -3.010  1.00 60.61  ? 6   MET A HE2  1 
ATOM   103  H HE3  . MET A 1 6   ? -8.634  14.787  -3.159  1.00 60.61  ? 6   MET A HE3  1 
ATOM   104  N N    . ALA A 1 7   ? -4.048  14.028  0.166   1.00 36.31  ? 7   ALA A N    1 
ATOM   105  C CA   . ALA A 1 7   ? -4.059  15.037  1.209   1.00 43.61  ? 7   ALA A CA   1 
ATOM   106  C C    . ALA A 1 7   ? -4.730  16.306  0.707   1.00 46.76  ? 7   ALA A C    1 
ATOM   107  O O    . ALA A 1 7   ? -4.828  16.557  -0.496  1.00 35.71  ? 7   ALA A O    1 
ATOM   108  C CB   . ALA A 1 7   ? -2.638  15.360  1.674   1.00 39.13  ? 7   ALA A CB   1 
ATOM   109  H H    . ALA A 1 7   ? -3.397  14.117  -0.390  1.00 43.62  ? 7   ALA A H    1 
ATOM   110  H HA   . ALA A 1 7   ? -4.557  14.700  1.970   1.00 52.39  ? 7   ALA A HA   1 
ATOM   111  H HB1  . ALA A 1 7   ? -2.678  16.039  2.365   1.00 47.02  ? 7   ALA A HB1  1 
ATOM   112  H HB2  . ALA A 1 7   ? -2.230  14.553  2.026   1.00 47.02  ? 7   ALA A HB2  1 
ATOM   113  H HB3  . ALA A 1 7   ? -2.125  15.687  0.918   1.00 47.02  ? 7   ALA A HB3  1 
ATOM   114  N N    . PHE A 1 8   ? -5.185  17.113  1.654   1.00 39.81  ? 8   PHE A N    1 
ATOM   115  C CA   . PHE A 1 8   ? -5.719  18.417  1.318   1.00 40.52  ? 8   PHE A CA   1 
ATOM   116  C C    . PHE A 1 8   ? -4.581  19.363  0.938   1.00 36.64  ? 8   PHE A C    1 
ATOM   117  O O    . PHE A 1 8   ? -3.466  19.245  1.455   1.00 39.35  ? 8   PHE A O    1 
ATOM   118  C CB   . PHE A 1 8   ? -6.490  18.997  2.498   1.00 41.31  ? 8   PHE A CB   1 
ATOM   119  C CG   . PHE A 1 8   ? -7.819  18.346  2.737   1.00 42.01  ? 8   PHE A CG   1 
ATOM   120  C CD1  . PHE A 1 8   ? -8.913  18.663  1.949   1.00 43.54  ? 8   PHE A CD1  1 
ATOM   121  C CD2  . PHE A 1 8   ? -7.979  17.426  3.757   1.00 46.92  ? 8   PHE A CD2  1 
ATOM   122  C CE1  . PHE A 1 8   ? -10.138 18.068  2.172   1.00 47.25  ? 8   PHE A CE1  1 
ATOM   123  C CE2  . PHE A 1 8   ? -9.203  16.830  3.985   1.00 41.75  ? 8   PHE A CE2  1 
ATOM   124  C CZ   . PHE A 1 8   ? -10.283 17.151  3.192   1.00 50.17  ? 8   PHE A CZ   1 
ATOM   125  H H    . PHE A 1 8   ? -5.194  16.929  2.494   1.00 47.83  ? 8   PHE A H    1 
ATOM   126  H HA   . PHE A 1 8   ? -6.326  18.339  0.566   1.00 48.68  ? 8   PHE A HA   1 
ATOM   127  H HB2  . PHE A 1 8   ? -5.959  18.886  3.302   1.00 49.63  ? 8   PHE A HB2  1 
ATOM   128  H HB3  . PHE A 1 8   ? -6.649  19.939  2.333   1.00 49.63  ? 8   PHE A HB3  1 
ATOM   129  H HD1  . PHE A 1 8   ? -8.820  19.283  1.262   1.00 52.30  ? 8   PHE A HD1  1 
ATOM   130  H HD2  . PHE A 1 8   ? -7.253  17.206  4.296   1.00 56.36  ? 8   PHE A HD2  1 
ATOM   131  H HE1  . PHE A 1 8   ? -10.866 18.286  1.635   1.00 56.76  ? 8   PHE A HE1  1 
ATOM   132  H HE2  . PHE A 1 8   ? -9.298  16.212  4.673   1.00 50.16  ? 8   PHE A HE2  1 
ATOM   133  H HZ   . PHE A 1 8   ? -11.108 16.751  3.344   1.00 60.27  ? 8   PHE A HZ   1 
ATOM   134  N N    . PRO A 1 9   ? -4.836  20.311  0.037   1.00 38.61  ? 9   PRO A N    1 
ATOM   135  C CA   . PRO A 1 9   ? -3.823  21.334  -0.253  1.00 37.78  ? 9   PRO A CA   1 
ATOM   136  C C    . PRO A 1 9   ? -3.417  22.041  1.031   1.00 34.52  ? 9   PRO A C    1 
ATOM   137  O O    . PRO A 1 9   ? -4.260  22.388  1.861   1.00 44.85  ? 9   PRO A O    1 
ATOM   138  C CB   . PRO A 1 9   ? -4.534  22.282  -1.226  1.00 41.67  ? 9   PRO A CB   1 
ATOM   139  C CG   . PRO A 1 9   ? -5.684  21.489  -1.771  1.00 42.85  ? 9   PRO A CG   1 
ATOM   140  C CD   . PRO A 1 9   ? -6.111  20.591  -0.646  1.00 39.88  ? 9   PRO A CD   1 
ATOM   141  H HA   . PRO A 1 9   ? -3.045  20.955  -0.691  1.00 45.40  ? 9   PRO A HA   1 
ATOM   142  H HB2  . PRO A 1 9   ? -4.848  23.068  -0.751  1.00 50.06  ? 9   PRO A HB2  1 
ATOM   143  H HB3  . PRO A 1 9   ? -3.926  22.544  -1.935  1.00 50.06  ? 9   PRO A HB3  1 
ATOM   144  H HG2  . PRO A 1 9   ? -6.404  22.086  -2.029  1.00 51.47  ? 9   PRO A HG2  1 
ATOM   145  H HG3  . PRO A 1 9   ? -5.393  20.969  -2.536  1.00 51.47  ? 9   PRO A HG3  1 
ATOM   146  H HD2  . PRO A 1 9   ? -6.731  21.045  -0.054  1.00 47.91  ? 9   PRO A HD2  1 
ATOM   147  H HD3  . PRO A 1 9   ? -6.512  19.775  -0.984  1.00 47.91  ? 9   PRO A HD3  1 
ATOM   148  N N    . SER A 1 10  ? -2.114  22.272  1.179   1.00 38.49  ? 10  SER A N    1 
ATOM   149  C CA   . SER A 1 10  ? -1.538  22.673  2.456   1.00 41.56  ? 10  SER A CA   1 
ATOM   150  C C    . SER A 1 10  ? -1.225  24.160  2.555   1.00 42.60  ? 10  SER A C    1 
ATOM   151  O O    . SER A 1 10  ? -0.799  24.615  3.621   1.00 40.81  ? 10  SER A O    1 
ATOM   152  C CB   . SER A 1 10  ? -0.260  21.859  2.716   1.00 39.73  ? 10  SER A CB   1 
ATOM   153  O OG   . SER A 1 10  ? 0.708   22.072  1.700   1.00 41.64  ? 10  SER A OG   1 
ATOM   154  H H    . SER A 1 10  ? -1.538  22.201  0.545   1.00 46.24  ? 10  SER A H    1 
ATOM   155  H HA   . SER A 1 10  ? -2.182  22.476  3.154   1.00 49.93  ? 10  SER A HA   1 
ATOM   156  H HB2  . SER A 1 10  ? 0.115   22.130  3.569   1.00 47.73  ? 10  SER A HB2  1 
ATOM   157  H HB3  . SER A 1 10  ? -0.488  20.917  2.739   1.00 47.73  ? 10  SER A HB3  1 
ATOM   158  H HG   . SER A 1 10  ? 0.910   22.887  1.662   1.00 50.02  ? 10  SER A HG   1 
ATOM   159  N N    . GLY A 1 11  ? -1.451  24.929  1.489   1.00 43.86  ? 11  GLY A N    1 
ATOM   160  C CA   . GLY A 1 11  ? -1.053  26.329  1.495   1.00 41.10  ? 11  GLY A CA   1 
ATOM   161  C C    . GLY A 1 11  ? -1.579  27.102  2.689   1.00 41.15  ? 11  GLY A C    1 
ATOM   162  O O    . GLY A 1 11  ? -0.831  27.817  3.362   1.00 49.26  ? 11  GLY A O    1 
ATOM   163  H H    . GLY A 1 11  ? -1.828  24.666  0.762   1.00 52.69  ? 11  GLY A H    1 
ATOM   164  H HA2  . GLY A 1 11  ? -0.084  26.383  1.505   1.00 49.37  ? 11  GLY A HA2  1 
ATOM   165  H HA3  . GLY A 1 11  ? -1.385  26.756  0.690   1.00 49.37  ? 11  GLY A HA3  1 
ATOM   166  N N    . LYS A 1 12  ? -2.879  26.976  2.965   1.00 38.80  ? 12  LYS A N    1 
ATOM   167  C CA   . LYS A 1 12  ? -3.474  27.739  4.058   1.00 46.51  ? 12  LYS A CA   1 
ATOM   168  C C    . LYS A 1 12  ? -2.786  27.453  5.388   1.00 43.49  ? 12  LYS A C    1 
ATOM   169  O O    . LYS A 1 12  ? -2.701  28.343  6.243   1.00 47.22  ? 12  LYS A O    1 
ATOM   170  C CB   . LYS A 1 12  ? -4.965  27.428  4.167   1.00 45.21  ? 12  LYS A CB   1 
ATOM   171  C CG   . LYS A 1 12  ? -5.778  27.798  2.940   1.00 51.67  ? 12  LYS A CG   1 
ATOM   172  C CD   . LYS A 1 12  ? -7.267  27.772  3.252   1.00 54.57  ? 12  LYS A CD   1 
ATOM   173  C CE   . LYS A 1 12  ? -8.112  27.773  1.985   1.00 64.79  ? 12  LYS A CE   1 
ATOM   174  N NZ   . LYS A 1 12  ? -7.368  28.264  0.790   1.00 75.47  ? 12  LYS A NZ   1 
ATOM   175  H H    . LYS A 1 12  ? -3.427  26.466  2.542   1.00 46.62  ? 12  LYS A H    1 
ATOM   176  H HA   . LYS A 1 12  ? -3.373  28.683  3.863   1.00 55.86  ? 12  LYS A HA   1 
ATOM   177  H HB2  . LYS A 1 12  ? -5.072  26.475  4.313   1.00 54.31  ? 12  LYS A HB2  1 
ATOM   178  H HB3  . LYS A 1 12  ? -5.329  27.921  4.919   1.00 54.31  ? 12  LYS A HB3  1 
ATOM   179  H HG2  . LYS A 1 12  ? -5.540  28.692  2.651   1.00 62.06  ? 12  LYS A HG2  1 
ATOM   180  H HG3  . LYS A 1 12  ? -5.601  27.161  2.230   1.00 62.06  ? 12  LYS A HG3  1 
ATOM   181  H HD2  . LYS A 1 12  ? -7.474  26.969  3.755   1.00 65.54  ? 12  LYS A HD2  1 
ATOM   182  H HD3  . LYS A 1 12  ? -7.498  28.557  3.772   1.00 65.54  ? 12  LYS A HD3  1 
ATOM   183  H HE2  . LYS A 1 12  ? -8.407  26.867  1.802   1.00 77.80  ? 12  LYS A HE2  1 
ATOM   184  H HE3  . LYS A 1 12  ? -8.879  28.351  2.118   1.00 77.80  ? 12  LYS A HE3  1 
ATOM   185  H HZ1  . LYS A 1 12  ? -7.928  28.376  0.107   1.00 90.63  ? 12  LYS A HZ1  1 
ATOM   186  H HZ2  . LYS A 1 12  ? -6.977  29.043  0.973   1.00 90.63  ? 12  LYS A HZ2  1 
ATOM   187  H HZ3  . LYS A 1 12  ? -6.743  27.675  0.557   1.00 90.63  ? 12  LYS A HZ3  1 
ATOM   188  N N    . VAL A 1 13  ? -2.290  26.227  5.581   1.00 41.07  ? 13  VAL A N    1 
ATOM   189  C CA   . VAL A 1 13  ? -1.614  25.890  6.832   1.00 46.21  ? 13  VAL A CA   1 
ATOM   190  C C    . VAL A 1 13  ? -0.141  26.284  6.793   1.00 37.43  ? 13  VAL A C    1 
ATOM   191  O O    . VAL A 1 13  ? 0.437   26.634  7.830   1.00 40.58  ? 13  VAL A O    1 
ATOM   192  C CB   . VAL A 1 13  ? -1.777  24.389  7.133   1.00 39.24  ? 13  VAL A CB   1 
ATOM   193  C CG1  . VAL A 1 13  ? -1.031  24.006  8.406   1.00 41.32  ? 13  VAL A CG1  1 
ATOM   194  C CG2  . VAL A 1 13  ? -3.249  24.036  7.242   1.00 41.16  ? 13  VAL A CG2  1 
ATOM   195  H H    . VAL A 1 13  ? -2.331  25.583  5.012   1.00 49.35  ? 13  VAL A H    1 
ATOM   196  H HA   . VAL A 1 13  ? -2.034  26.393  7.547   1.00 55.50  ? 13  VAL A HA   1 
ATOM   197  H HB   . VAL A 1 13  ? -1.392  23.878  6.404   1.00 47.15  ? 13  VAL A HB   1 
ATOM   198  H HG11 . VAL A 1 13  ? -1.323  23.126  8.690   1.00 49.65  ? 13  VAL A HG11 1 
ATOM   199  H HG12 . VAL A 1 13  ? -0.078  23.994  8.223   1.00 49.65  ? 13  VAL A HG12 1 
ATOM   200  H HG13 . VAL A 1 13  ? -1.227  24.659  9.096   1.00 49.65  ? 13  VAL A HG13 1 
ATOM   201  H HG21 . VAL A 1 13  ? -3.332  23.105  7.502   1.00 49.45  ? 13  VAL A HG21 1 
ATOM   202  H HG22 . VAL A 1 13  ? -3.661  24.604  7.912   1.00 49.45  ? 13  VAL A HG22 1 
ATOM   203  H HG23 . VAL A 1 13  ? -3.673  24.178  6.381   1.00 49.45  ? 13  VAL A HG23 1 
ATOM   204  N N    . GLU A 1 14  ? 0.496   26.220  5.616   1.00 43.97  ? 14  GLU A N    1 
ATOM   205  C CA   . GLU A 1 14  ? 1.907   26.585  5.505   1.00 35.92  ? 14  GLU A CA   1 
ATOM   206  C C    . GLU A 1 14  ? 2.162   27.986  6.051   1.00 40.92  ? 14  GLU A C    1 
ATOM   207  O O    . GLU A 1 14  ? 3.148   28.217  6.763   1.00 46.69  ? 14  GLU A O    1 
ATOM   208  C CB   . GLU A 1 14  ? 2.356   26.503  4.039   1.00 44.09  ? 14  GLU A CB   1 
ATOM   209  C CG   . GLU A 1 14  ? 2.474   25.087  3.460   1.00 42.53  ? 14  GLU A CG   1 
ATOM   210  C CD   . GLU A 1 14  ? 2.564   25.063  1.930   1.00 45.12  ? 14  GLU A CD   1 
ATOM   211  O OE1  . GLU A 1 14  ? 3.512   25.651  1.366   1.00 37.09  ? 14  GLU A OE1  1 
ATOM   212  O OE2  . GLU A 1 14  ? 1.689   24.440  1.288   1.00 39.25  ? 14  GLU A OE2  1 
ATOM   213  H H    . GLU A 1 14  ? 0.135   25.971  4.876   1.00 52.82  ? 14  GLU A H    1 
ATOM   214  H HA   . GLU A 1 14  ? 2.432   25.955  6.023   1.00 43.16  ? 14  GLU A HA   1 
ATOM   215  H HB2  . GLU A 1 14  ? 1.712   26.984  3.496   1.00 52.97  ? 14  GLU A HB2  1 
ATOM   216  H HB3  . GLU A 1 14  ? 3.229   26.919  3.964   1.00 52.97  ? 14  GLU A HB3  1 
ATOM   217  H HG2  . GLU A 1 14  ? 3.276   24.670  3.812   1.00 51.09  ? 14  GLU A HG2  1 
ATOM   218  H HG3  . GLU A 1 14  ? 1.692   24.576  3.720   1.00 51.09  ? 14  GLU A HG3  1 
ATOM   219  N N    . GLY A 1 15  ? 1.286   28.935  5.721   1.00 39.22  ? 15  GLY A N    1 
ATOM   220  C CA   . GLY A 1 15  ? 1.435   30.302  6.175   1.00 52.85  ? 15  GLY A CA   1 
ATOM   221  C C    . GLY A 1 15  ? 1.253   30.497  7.661   1.00 51.85  ? 15  GLY A C    1 
ATOM   222  O O    . GLY A 1 15  ? 1.468   31.612  8.149   1.00 45.78  ? 15  GLY A O    1 
ATOM   223  H H    . GLY A 1 15  ? 0.592   28.804  5.230   1.00 47.12  ? 15  GLY A H    1 
ATOM   224  H HA2  . GLY A 1 15  ? 2.325   30.612  5.943   1.00 63.48  ? 15  GLY A HA2  1 
ATOM   225  H HA3  . GLY A 1 15  ? 0.780   30.854  5.721   1.00 63.48  ? 15  GLY A HA3  1 
ATOM   226  N N    . CYS A 1 16  ? 0.868   29.447  8.386   1.00 42.13  ? 16  CYS A N    1 
ATOM   227  C CA   . CYS A 1 16  ? 0.691   29.525  9.828   1.00 48.97  ? 16  CYS A CA   1 
ATOM   228  C C    . CYS A 1 16  ? 1.863   28.958  10.615  1.00 49.77  ? 16  CYS A C    1 
ATOM   229  O O    . CYS A 1 16  ? 1.879   29.089  11.843  1.00 49.93  ? 16  CYS A O    1 
ATOM   230  C CB   . CYS A 1 16  ? -0.577  28.772  10.254  1.00 46.30  ? 16  CYS A CB   1 
ATOM   231  S SG   . CYS A 1 16  ? -2.099  29.338  9.495   1.00 48.02  ? 16  CYS A SG   1 
ATOM   232  H H    . CYS A 1 16  ? 0.702   28.670  8.058   1.00 50.62  ? 16  CYS A H    1 
ATOM   233  H HA   . CYS A 1 16  ? 0.589   30.461  10.062  1.00 58.82  ? 16  CYS A HA   1 
ATOM   234  H HB2  . CYS A 1 16  ? -0.469  27.837  10.023  1.00 55.61  ? 16  CYS A HB2  1 
ATOM   235  H HB3  . CYS A 1 16  ? -0.680  28.867  11.214  1.00 55.61  ? 16  CYS A HB3  1 
ATOM   236  H HG   . CYS A 1 16  ? -1.962  29.345  8.303   1.00 57.68  ? 16  CYS A HG   1 
ATOM   237  N N    . MET A 1 17  ? 2.828   28.324  9.957   1.00 44.30  ? 17  MET A N    1 
ATOM   238  C CA   . MET A 1 17  ? 3.862   27.584  10.666  1.00 45.92  ? 17  MET A CA   1 
ATOM   239  C C    . MET A 1 17  ? 5.054   28.473  10.986  1.00 47.71  ? 17  MET A C    1 
ATOM   240  O O    . MET A 1 17  ? 5.517   29.251  10.147  1.00 49.52  ? 17  MET A O    1 
ATOM   241  C CB   . MET A 1 17  ? 4.313   26.376  9.848   1.00 44.26  ? 17  MET A CB   1 
ATOM   242  C CG   . MET A 1 17  ? 3.155   25.537  9.341   1.00 39.94  ? 17  MET A CG   1 
ATOM   243  S SD   . MET A 1 17  ? 2.143   24.815  10.655  1.00 41.60  ? 17  MET A SD   1 
ATOM   244  C CE   . MET A 1 17  ? 3.366   24.315  11.861  1.00 39.41  ? 17  MET A CE   1 
ATOM   245  H H    . MET A 1 17  ? 2.904   28.307  9.101   1.00 53.22  ? 17  MET A H    1 
ATOM   246  H HA   . MET A 1 17  ? 3.491   27.262  11.502  1.00 55.16  ? 17  MET A HA   1 
ATOM   247  H HB2  . MET A 1 17  ? 4.817   26.686  9.079   1.00 53.17  ? 17  MET A HB2  1 
ATOM   248  H HB3  . MET A 1 17  ? 4.872   25.810  10.404  1.00 53.17  ? 17  MET A HB3  1 
ATOM   249  H HG2  . MET A 1 17  ? 2.578   26.097  8.799   1.00 47.99  ? 17  MET A HG2  1 
ATOM   250  H HG3  . MET A 1 17  ? 3.507   24.809  8.806   1.00 47.99  ? 17  MET A HG3  1 
ATOM   251  H HE1  . MET A 1 17  ? 2.918   23.881  12.604  1.00 47.35  ? 17  MET A HE1  1 
ATOM   252  H HE2  . MET A 1 17  ? 3.988   23.699  11.444  1.00 47.35  ? 17  MET A HE2  1 
ATOM   253  H HE3  . MET A 1 17  ? 3.840   25.102  12.175  1.00 47.35  ? 17  MET A HE3  1 
ATOM   254  N N    . VAL A 1 18  ? 5.542   28.345  12.218  1.00 50.38  ? 18  VAL A N    1 
ATOM   255  C CA   . VAL A 1 18  ? 6.653   29.132  12.732  1.00 50.52  ? 18  VAL A CA   1 
ATOM   256  C C    . VAL A 1 18  ? 7.545   28.211  13.553  1.00 48.14  ? 18  VAL A C    1 
ATOM   257  O O    . VAL A 1 18  ? 7.173   27.087  13.894  1.00 44.60  ? 18  VAL A O    1 
ATOM   258  C CB   . VAL A 1 18  ? 6.167   30.326  13.579  1.00 56.28  ? 18  VAL A CB   1 
ATOM   259  C CG1  . VAL A 1 18  ? 5.182   31.169  12.780  1.00 50.30  ? 18  VAL A CG1  1 
ATOM   260  C CG2  . VAL A 1 18  ? 5.530   29.834  14.871  1.00 50.16  ? 18  VAL A CG2  1 
ATOM   261  H H    . VAL A 1 18  ? 5.233   27.786  12.794  1.00 60.51  ? 18  VAL A H    1 
ATOM   262  H HA   . VAL A 1 18  ? 7.178   29.482  11.995  1.00 60.68  ? 18  VAL A HA   1 
ATOM   263  H HB   . VAL A 1 18  ? 6.926   30.883  13.812  1.00 67.60  ? 18  VAL A HB   1 
ATOM   264  H HG11 . VAL A 1 18  ? 4.955   31.961  13.292  1.00 60.41  ? 18  VAL A HG11 1 
ATOM   265  H HG12 . VAL A 1 18  ? 5.595   31.425  11.940  1.00 60.41  ? 18  VAL A HG12 1 
ATOM   266  H HG13 . VAL A 1 18  ? 4.383   30.645  12.610  1.00 60.41  ? 18  VAL A HG13 1 
ATOM   267  H HG21 . VAL A 1 18  ? 5.018   30.557  15.266  1.00 60.25  ? 18  VAL A HG21 1 
ATOM   268  H HG22 . VAL A 1 18  ? 4.946   29.086  14.671  1.00 60.25  ? 18  VAL A HG22 1 
ATOM   269  H HG23 . VAL A 1 18  ? 6.230   29.553  15.481  1.00 60.25  ? 18  VAL A HG23 1 
ATOM   270  N N    . GLN A 1 19  ? 8.741   28.700  13.861  1.00 48.49  ? 19  GLN A N    1 
ATOM   271  C CA   . GLN A 1 19  ? 9.702   27.975  14.680  1.00 53.37  ? 19  GLN A CA   1 
ATOM   272  C C    . GLN A 1 19  ? 9.697   28.567  16.083  1.00 42.28  ? 19  GLN A C    1 
ATOM   273  O O    . GLN A 1 19  ? 9.736   29.792  16.243  1.00 45.94  ? 19  GLN A O    1 
ATOM   274  C CB   . GLN A 1 19  ? 11.102  28.054  14.070  1.00 51.33  ? 19  GLN A CB   1 
ATOM   275  C CG   . GLN A 1 19  ? 12.167  27.305  14.851  1.00 57.17  ? 19  GLN A CG   1 
ATOM   276  C CD   . GLN A 1 19  ? 13.567  27.586  14.339  1.00 60.60  ? 19  GLN A CD   1 
ATOM   277  O OE1  . GLN A 1 19  ? 14.302  26.670  13.971  1.00 60.84  ? 19  GLN A OE1  1 
ATOM   278  N NE2  . GLN A 1 19  ? 13.942  28.859  14.311  1.00 70.89  ? 19  GLN A NE2  1 
ATOM   279  H H    . GLN A 1 19  ? 9.024   29.469  13.601  1.00 58.24  ? 19  GLN A H    1 
ATOM   280  H HA   . GLN A 1 19  ? 9.454   27.039  14.737  1.00 64.11  ? 19  GLN A HA   1 
ATOM   281  H HB2  . GLN A 1 19  ? 11.072  27.677  13.177  1.00 61.65  ? 19  GLN A HB2  1 
ATOM   282  H HB3  . GLN A 1 19  ? 11.369  28.986  14.028  1.00 61.65  ? 19  GLN A HB3  1 
ATOM   283  H HG2  . GLN A 1 19  ? 12.127  27.575  15.782  1.00 68.66  ? 19  GLN A HG2  1 
ATOM   284  H HG3  . GLN A 1 19  ? 12.004  26.351  14.775  1.00 68.66  ? 19  GLN A HG3  1 
ATOM   285  H HE21 . GLN A 1 19  ? 13.401  29.473  14.575  1.00 85.13  ? 19  GLN A HE21 1 
ATOM   286  H HE22 . GLN A 1 19  ? 14.727  29.070  14.029  1.00 85.13  ? 19  GLN A HE22 1 
ATOM   287  N N    . VAL A 1 20  ? 9.637   27.702  17.093  1.00 42.15  ? 20  VAL A N    1 
ATOM   288  C CA   . VAL A 1 20  ? 9.690   28.120  18.490  1.00 44.97  ? 20  VAL A CA   1 
ATOM   289  C C    . VAL A 1 20  ? 10.937  27.511  19.108  1.00 48.48  ? 20  VAL A C    1 
ATOM   290  O O    . VAL A 1 20  ? 11.124  26.287  19.071  1.00 47.89  ? 20  VAL A O    1 
ATOM   291  C CB   . VAL A 1 20  ? 8.444   27.701  19.279  1.00 43.88  ? 20  VAL A CB   1 
ATOM   292  C CG1  . VAL A 1 20  ? 8.549   28.199  20.720  1.00 49.30  ? 20  VAL A CG1  1 
ATOM   293  C CG2  . VAL A 1 20  ? 7.191   28.237  18.627  1.00 48.47  ? 20  VAL A CG2  1 
ATOM   294  H H    . VAL A 1 20  ? 9.565   26.851  16.991  1.00 50.64  ? 20  VAL A H    1 
ATOM   295  H HA   . VAL A 1 20  ? 9.757   29.087  18.523  1.00 54.02  ? 20  VAL A HA   1 
ATOM   296  H HB   . VAL A 1 20  ? 8.385   26.732  19.286  1.00 52.71  ? 20  VAL A HB   1 
ATOM   297  H HG11 . VAL A 1 20  ? 7.694   28.074  21.161  1.00 59.22  ? 20  VAL A HG11 1 
ATOM   298  H HG12 . VAL A 1 20  ? 9.236   27.691  21.181  1.00 59.22  ? 20  VAL A HG12 1 
ATOM   299  H HG13 . VAL A 1 20  ? 8.783   29.140  20.713  1.00 59.22  ? 20  VAL A HG13 1 
ATOM   300  H HG21 . VAL A 1 20  ? 6.425   28.005  19.175  1.00 58.22  ? 20  VAL A HG21 1 
ATOM   301  H HG22 . VAL A 1 20  ? 7.263   29.201  18.550  1.00 58.22  ? 20  VAL A HG22 1 
ATOM   302  H HG23 . VAL A 1 20  ? 7.100   27.841  17.746  1.00 58.22  ? 20  VAL A HG23 1 
ATOM   303  N N    . THR A 1 21  ? 11.778  28.358  19.691  1.00 48.08  ? 21  THR A N    1 
ATOM   304  C CA   . THR A 1 21  ? 13.010  27.926  20.327  1.00 51.30  ? 21  THR A CA   1 
ATOM   305  C C    . THR A 1 21  ? 13.020  28.413  21.766  1.00 49.69  ? 21  THR A C    1 
ATOM   306  O O    . THR A 1 21  ? 12.754  29.589  22.033  1.00 42.63  ? 21  THR A O    1 
ATOM   307  C CB   . THR A 1 21  ? 14.239  28.456  19.584  1.00 56.22  ? 21  THR A CB   1 
ATOM   308  O OG1  . THR A 1 21  ? 14.187  28.039  18.214  1.00 53.89  ? 21  THR A OG1  1 
ATOM   309  C CG2  . THR A 1 21  ? 15.514  27.932  20.234  1.00 48.33  ? 21  THR A CG2  1 
ATOM   310  H H    . THR A 1 21  ? 11.650  29.208  19.730  1.00 57.76  ? 21  THR A H    1 
ATOM   311  H HA   . THR A 1 21  ? 13.052  26.957  20.324  1.00 61.62  ? 21  THR A HA   1 
ATOM   312  H HB   . THR A 1 21  ? 14.254  29.425  19.621  1.00 67.52  ? 21  THR A HB   1 
ATOM   313  H HG1  . THR A 1 21  ? 14.855  28.333  17.798  1.00 64.73  ? 21  THR A HG1  1 
ATOM   314  H HG21 . THR A 1 21  ? 16.279  28.131  19.673  1.00 58.05  ? 21  THR A HG21 1 
ATOM   315  H HG22 . THR A 1 21  ? 15.641  28.350  21.100  1.00 58.05  ? 21  THR A HG22 1 
ATOM   316  H HG23 . THR A 1 21  ? 15.454  26.971  20.355  1.00 58.05  ? 21  THR A HG23 1 
ATOM   317  N N    . CYS A 1 22  ? 13.316  27.501  22.686  1.00 47.22  ? 22  CYS A N    1 
ATOM   318  C CA   . CYS A 1 22  ? 13.508  27.820  24.095  1.00 45.76  ? 22  CYS A CA   1 
ATOM   319  C C    . CYS A 1 22  ? 14.790  27.120  24.523  1.00 52.99  ? 22  CYS A C    1 
ATOM   320  O O    . CYS A 1 22  ? 14.854  25.885  24.528  1.00 55.59  ? 22  CYS A O    1 
ATOM   321  C CB   . CYS A 1 22  ? 12.319  27.371  24.937  1.00 47.07  ? 22  CYS A CB   1 
ATOM   322  S SG   . CYS A 1 22  ? 12.227  28.187  26.545  1.00 66.55  ? 22  CYS A SG   1 
ATOM   323  H H    . CYS A 1 22  ? 13.413  26.664  22.512  1.00 56.73  ? 22  CYS A H    1 
ATOM   324  H HA   . CYS A 1 22  ? 13.604  28.777  24.220  1.00 54.97  ? 22  CYS A HA   1 
ATOM   325  H HB2  . CYS A 1 22  ? 11.501  27.571  24.455  1.00 56.54  ? 22  CYS A HB2  1 
ATOM   326  H HB3  . CYS A 1 22  ? 12.387  26.416  25.092  1.00 56.54  ? 22  CYS A HB3  1 
ATOM   327  H HG   . CYS A 1 22  ? 12.094  29.368  26.377  1.00 79.92  ? 22  CYS A HG   1 
ATOM   328  N N    . GLY A 1 23  ? 15.808  27.901  24.849  1.00 56.35  ? 23  GLY A N    1 
ATOM   329  C CA   . GLY A 1 23  ? 17.097  27.319  25.206  1.00 54.06  ? 23  GLY A CA   1 
ATOM   330  C C    . GLY A 1 23  ? 17.693  26.601  24.010  1.00 53.91  ? 23  GLY A C    1 
ATOM   331  O O    . GLY A 1 23  ? 17.914  27.184  22.940  1.00 51.01  ? 23  GLY A O    1 
ATOM   332  H H    . GLY A 1 23  ? 15.783  28.760  24.872  1.00 67.68  ? 23  GLY A H    1 
ATOM   333  H HA2  . GLY A 1 23  ? 17.707  28.017  25.491  1.00 64.93  ? 23  GLY A HA2  1 
ATOM   334  H HA3  . GLY A 1 23  ? 16.983  26.684  25.930  1.00 64.93  ? 23  GLY A HA3  1 
ATOM   335  N N    . THR A 1 24  ? 17.969  25.308  24.186  1.00 64.42  ? 24  THR A N    1 
ATOM   336  C CA   . THR A 1 24  ? 18.515  24.469  23.129  1.00 61.99  ? 24  THR A CA   1 
ATOM   337  C C    . THR A 1 24  ? 17.458  23.618  22.437  1.00 59.66  ? 24  THR A C    1 
ATOM   338  O O    . THR A 1 24  ? 17.804  22.811  21.569  1.00 62.09  ? 24  THR A O    1 
ATOM   339  C CB   . THR A 1 24  ? 19.605  23.549  23.695  1.00 58.91  ? 24  THR A CB   1 
ATOM   340  O OG1  . THR A 1 24  ? 20.166  22.759  22.638  1.00 75.31  ? 24  THR A OG1  1 
ATOM   341  C CG2  . THR A 1 24  ? 19.028  22.623  24.759  1.00 59.95  ? 24  THR A CG2  1 
ATOM   342  H H    . THR A 1 24  ? 17.844  24.889  24.926  1.00 77.36  ? 24  THR A H    1 
ATOM   343  H HA   . THR A 1 24  ? 18.920  25.046  22.463  1.00 74.45  ? 24  THR A HA   1 
ATOM   344  H HB   . THR A 1 24  ? 20.300  24.090  24.101  1.00 70.75  ? 24  THR A HB   1 
ATOM   345  H HG1  . THR A 1 24  ? 20.486  23.259  22.044  1.00 90.43  ? 24  THR A HG1  1 
ATOM   346  H HG21 . THR A 1 24  ? 19.720  22.029  25.092  1.00 71.99  ? 24  THR A HG21 1 
ATOM   347  H HG22 . THR A 1 24  ? 18.678  23.144  25.498  1.00 71.99  ? 24  THR A HG22 1 
ATOM   348  H HG23 . THR A 1 24  ? 18.311  22.090  24.381  1.00 71.99  ? 24  THR A HG23 1 
ATOM   349  N N    . THR A 1 25  ? 16.189  23.771  22.802  1.00 59.29  ? 25  THR A N    1 
ATOM   350  C CA   . THR A 1 25  ? 15.109  22.950  22.271  1.00 56.42  ? 25  THR A CA   1 
ATOM   351  C C    . THR A 1 25  ? 14.309  23.754  21.256  1.00 49.46  ? 25  THR A C    1 
ATOM   352  O O    . THR A 1 25  ? 13.839  24.853  21.561  1.00 48.68  ? 25  THR A O    1 
ATOM   353  C CB   . THR A 1 25  ? 14.195  22.467  23.402  1.00 56.44  ? 25  THR A CB   1 
ATOM   354  O OG1  . THR A 1 25  ? 14.968  21.739  24.367  1.00 53.22  ? 25  THR A OG1  1 
ATOM   355  C CG2  . THR A 1 25  ? 13.085  21.572  22.864  1.00 58.18  ? 25  THR A CG2  1 
ATOM   356  H H    . THR A 1 25  ? 15.923  24.359  23.370  1.00 71.20  ? 25  THR A H    1 
ATOM   357  H HA   . THR A 1 25  ? 15.480  22.175  21.822  1.00 67.76  ? 25  THR A HA   1 
ATOM   358  H HB   . THR A 1 25  ? 13.781  23.234  23.828  1.00 67.78  ? 25  THR A HB   1 
ATOM   359  H HG1  . THR A 1 25  ? 14.464  21.417  24.956  1.00 63.93  ? 25  THR A HG1  1 
ATOM   360  H HG21 . THR A 1 25  ? 12.627  21.134  23.598  1.00 69.88  ? 25  THR A HG21 1 
ATOM   361  H HG22 . THR A 1 25  ? 12.445  22.102  22.364  1.00 69.88  ? 25  THR A HG22 1 
ATOM   362  H HG23 . THR A 1 25  ? 13.460  20.896  22.278  1.00 69.88  ? 25  THR A HG23 1 
ATOM   363  N N    . THR A 1 26  ? 14.164  23.209  20.052  1.00 50.04  ? 26  THR A N    1 
ATOM   364  C CA   . THR A 1 26  ? 13.417  23.864  18.988  1.00 52.18  ? 26  THR A CA   1 
ATOM   365  C C    . THR A 1 26  ? 12.333  22.932  18.466  1.00 37.54  ? 26  THR A C    1 
ATOM   366  O O    . THR A 1 26  ? 12.534  21.716  18.374  1.00 49.06  ? 26  THR A O    1 
ATOM   367  C CB   . THR A 1 26  ? 14.343  24.294  17.841  1.00 49.10  ? 26  THR A CB   1 
ATOM   368  O OG1  . THR A 1 26  ? 15.028  25.500  18.207  1.00 61.65  ? 26  THR A OG1  1 
ATOM   369  C CG2  . THR A 1 26  ? 13.554  24.540  16.563  1.00 55.21  ? 26  THR A CG2  1 
ATOM   370  H H    . THR A 1 26  ? 14.495  22.448  19.825  1.00 60.11  ? 26  THR A H    1 
ATOM   371  H HA   . THR A 1 26  ? 12.984  24.658  19.339  1.00 62.67  ? 26  THR A HA   1 
ATOM   372  H HB   . THR A 1 26  ? 14.985  23.588  17.669  1.00 58.97  ? 26  THR A HB   1 
ATOM   373  H HG1  . THR A 1 26  ? 14.473  26.116  18.341  1.00 74.04  ? 26  THR A HG1  1 
ATOM   374  H HG21 . THR A 1 26  ? 14.087  25.055  15.938  1.00 66.31  ? 26  THR A HG21 1 
ATOM   375  H HG22 . THR A 1 26  ? 13.316  23.694  16.152  1.00 66.31  ? 26  THR A HG22 1 
ATOM   376  H HG23 . THR A 1 26  ? 12.742  25.031  16.763  1.00 66.31  ? 26  THR A HG23 1 
ATOM   377  N N    . LEU A 1 27  ? 11.179  23.508  18.145  1.00 44.47  ? 27  LEU A N    1 
ATOM   378  C CA   . LEU A 1 27  ? 10.108  22.785  17.478  1.00 48.18  ? 27  LEU A CA   1 
ATOM   379  C C    . LEU A 1 27  ? 9.258   23.799  16.720  1.00 41.10  ? 27  LEU A C    1 
ATOM   380  O O    . LEU A 1 27  ? 9.624   24.973  16.602  1.00 44.43  ? 27  LEU A O    1 
ATOM   381  C CB   . LEU A 1 27  ? 9.294   21.963  18.480  1.00 50.20  ? 27  LEU A CB   1 
ATOM   382  C CG   . LEU A 1 27  ? 8.916   22.584  19.824  1.00 41.86  ? 27  LEU A CG   1 
ATOM   383  C CD1  . LEU A 1 27  ? 7.940   23.724  19.664  1.00 39.50  ? 27  LEU A CD1  1 
ATOM   384  C CD2  . LEU A 1 27  ? 8.330   21.497  20.721  1.00 40.37  ? 27  LEU A CD2  1 
ATOM   385  H H    . LEU A 1 27  ? 10.991  24.332  18.308  1.00 53.42  ? 27  LEU A H    1 
ATOM   386  H HA   . LEU A 1 27  ? 10.497  22.169  16.837  1.00 57.87  ? 27  LEU A HA   1 
ATOM   387  H HB2  . LEU A 1 27  ? 8.460   21.722  18.047  1.00 60.30  ? 27  LEU A HB2  1 
ATOM   388  H HB3  . LEU A 1 27  ? 9.805   21.164  18.683  1.00 60.30  ? 27  LEU A HB3  1 
ATOM   389  H HG   . LEU A 1 27  ? 9.709   22.958  20.238  1.00 50.28  ? 27  LEU A HG   1 
ATOM   390  H HD11 . LEU A 1 27  ? 7.635   24.004  20.541  1.00 47.46  ? 27  LEU A HD11 1 
ATOM   391  H HD12 . LEU A 1 27  ? 8.385   24.460  19.217  1.00 47.46  ? 27  LEU A HD12 1 
ATOM   392  H HD13 . LEU A 1 27  ? 7.186   23.422  19.133  1.00 47.46  ? 27  LEU A HD13 1 
ATOM   393  H HD21 . LEU A 1 27  ? 7.920   21.913  21.495  1.00 48.50  ? 27  LEU A HD21 1 
ATOM   394  H HD22 . LEU A 1 27  ? 7.664   21.000  20.221  1.00 48.50  ? 27  LEU A HD22 1 
ATOM   395  H HD23 . LEU A 1 27  ? 9.043   20.903  21.003  1.00 48.50  ? 27  LEU A HD23 1 
ATOM   396  N N    . ASN A 1 28  ? 8.119   23.345  16.202  1.00 42.07  ? 28  ASN A N    1 
ATOM   397  C CA   . ASN A 1 28  ? 7.242   24.177  15.394  1.00 40.16  ? 28  ASN A CA   1 
ATOM   398  C C    . ASN A 1 28  ? 6.059   24.684  16.208  1.00 37.41  ? 28  ASN A C    1 
ATOM   399  O O    . ASN A 1 28  ? 5.622   24.049  17.172  1.00 39.25  ? 28  ASN A O    1 
ATOM   400  C CB   . ASN A 1 28  ? 6.715   23.411  14.180  1.00 44.30  ? 28  ASN A CB   1 
ATOM   401  C CG   . ASN A 1 28  ? 7.800   22.657  13.447  1.00 37.47  ? 28  ASN A CG   1 
ATOM   402  O OD1  . ASN A 1 28  ? 8.537   23.233  12.644  1.00 42.93  ? 28  ASN A OD1  1 
ATOM   403  N ND2  . ASN A 1 28  ? 7.907   21.361  13.717  1.00 41.23  ? 28  ASN A ND2  1 
ATOM   404  H H    . ASN A 1 28  ? 7.830   22.542  16.308  1.00 50.54  ? 28  ASN A H    1 
ATOM   405  H HA   . ASN A 1 28  ? 7.752   24.943  15.085  1.00 48.24  ? 28  ASN A HA   1 
ATOM   406  H HB2  . ASN A 1 28  ? 6.051   22.769  14.475  1.00 53.22  ? 28  ASN A HB2  1 
ATOM   407  H HB3  . ASN A 1 28  ? 6.316   24.039  13.558  1.00 53.22  ? 28  ASN A HB3  1 
ATOM   408  H HD21 . ASN A 1 28  ? 8.509   20.889  13.325  1.00 49.53  ? 28  ASN A HD21 1 
ATOM   409  H HD22 . ASN A 1 28  ? 7.374   20.994  14.284  1.00 49.53  ? 28  ASN A HD22 1 
ATOM   410  N N    . GLY A 1 29  ? 5.538   25.839  15.793  1.00 39.29  ? 29  GLY A N    1 
ATOM   411  C CA   . GLY A 1 29  ? 4.332   26.377  16.373  1.00 38.69  ? 29  GLY A CA   1 
ATOM   412  C C    . GLY A 1 29  ? 3.330   26.741  15.296  1.00 43.81  ? 29  GLY A C    1 
ATOM   413  O O    . GLY A 1 29  ? 3.659   26.860  14.117  1.00 41.68  ? 29  GLY A O    1 
ATOM   414  H H    . GLY A 1 29  ? 5.875   26.328  15.171  1.00 47.20  ? 29  GLY A H    1 
ATOM   415  H HA2  . GLY A 1 29  ? 3.931   25.719  16.962  1.00 46.48  ? 29  GLY A HA2  1 
ATOM   416  H HA3  . GLY A 1 29  ? 4.542   27.173  16.886  1.00 46.48  ? 29  GLY A HA3  1 
ATOM   417  N N    . LEU A 1 30  ? 2.085   26.914  15.732  1.00 38.19  ? 30  LEU A N    1 
ATOM   418  C CA   . LEU A 1 30  ? 0.972   27.282  14.865  1.00 40.66  ? 30  LEU A CA   1 
ATOM   419  C C    . LEU A 1 30  ? 0.559   28.712  15.185  1.00 49.01  ? 30  LEU A C    1 
ATOM   420  O O    . LEU A 1 30  ? 0.081   28.989  16.290  1.00 42.67  ? 30  LEU A O    1 
ATOM   421  C CB   . LEU A 1 30  ? -0.205  26.328  15.055  1.00 46.56  ? 30  LEU A CB   1 
ATOM   422  C CG   . LEU A 1 30  ? -1.335  26.490  14.040  1.00 38.44  ? 30  LEU A CG   1 
ATOM   423  C CD1  . LEU A 1 30  ? -0.871  25.961  12.691  1.00 39.81  ? 30  LEU A CD1  1 
ATOM   424  C CD2  . LEU A 1 30  ? -2.595  25.782  14.494  1.00 40.41  ? 30  LEU A CD2  1 
ATOM   425  H H    . LEU A 1 30  ? 1.854   26.819  16.555  1.00 45.88  ? 30  LEU A H    1 
ATOM   426  H HA   . LEU A 1 30  ? 1.253   27.241  13.938  1.00 48.84  ? 30  LEU A HA   1 
ATOM   427  H HB2  . LEU A 1 30  ? 0.123   25.418  14.984  1.00 55.93  ? 30  LEU A HB2  1 
ATOM   428  H HB3  . LEU A 1 30  ? -0.582  26.477  15.936  1.00 55.93  ? 30  LEU A HB3  1 
ATOM   429  H HG   . LEU A 1 30  ? -1.560  27.430  13.953  1.00 46.19  ? 30  LEU A HG   1 
ATOM   430  H HD11 . LEU A 1 30  ? -1.617  25.982  12.071  1.00 47.83  ? 30  LEU A HD11 1 
ATOM   431  H HD12 . LEU A 1 30  ? -0.152  26.522  12.363  1.00 47.83  ? 30  LEU A HD12 1 
ATOM   432  H HD13 . LEU A 1 30  ? -0.557  25.050  12.800  1.00 47.83  ? 30  LEU A HD13 1 
ATOM   433  H HD21 . LEU A 1 30  ? -3.279  25.888  13.814  1.00 48.55  ? 30  LEU A HD21 1 
ATOM   434  H HD22 . LEU A 1 30  ? -2.400  24.841  14.624  1.00 48.55  ? 30  LEU A HD22 1 
ATOM   435  H HD23 . LEU A 1 30  ? -2.895  26.176  15.329  1.00 48.55  ? 30  LEU A HD23 1 
ATOM   436  N N    . TRP A 1 31  ? 0.729   29.606  14.212  1.00 44.36  ? 31  TRP A N    1 
ATOM   437  C CA   . TRP A 1 31  ? 0.516   31.043  14.390  1.00 47.74  ? 31  TRP A CA   1 
ATOM   438  C C    . TRP A 1 31  ? -0.847  31.410  13.813  1.00 54.87  ? 31  TRP A C    1 
ATOM   439  O O    . TRP A 1 31  ? -1.021  31.479  12.594  1.00 42.21  ? 31  TRP A O    1 
ATOM   440  C CB   . TRP A 1 31  ? 1.647   31.819  13.719  1.00 53.20  ? 31  TRP A CB   1 
ATOM   441  C CG   . TRP A 1 31  ? 1.576   33.309  13.868  1.00 57.63  ? 31  TRP A CG   1 
ATOM   442  C CD1  . TRP A 1 31  ? 0.900   34.011  14.823  1.00 57.61  ? 31  TRP A CD1  1 
ATOM   443  C CD2  . TRP A 1 31  ? 2.213   34.283  13.029  1.00 60.77  ? 31  TRP A CD2  1 
ATOM   444  N NE1  . TRP A 1 31  ? 1.074   35.361  14.630  1.00 57.97  ? 31  TRP A NE1  1 
ATOM   445  C CE2  . TRP A 1 31  ? 1.878   35.554  13.537  1.00 65.26  ? 31  TRP A CE2  1 
ATOM   446  C CE3  . TRP A 1 31  ? 3.029   34.202  11.897  1.00 50.36  ? 31  TRP A CE3  1 
ATOM   447  C CZ2  . TRP A 1 31  ? 2.328   36.735  12.949  1.00 61.93  ? 31  TRP A CZ2  1 
ATOM   448  C CZ3  . TRP A 1 31  ? 3.478   35.375  11.318  1.00 54.86  ? 31  TRP A CZ3  1 
ATOM   449  C CH2  . TRP A 1 31  ? 3.126   36.624  11.844  1.00 60.59  ? 31  TRP A CH2  1 
ATOM   450  H H    . TRP A 1 31  ? 0.975   29.399  13.415  1.00 53.29  ? 31  TRP A H    1 
ATOM   451  H HA   . TRP A 1 31  ? 0.500   31.257  15.336  1.00 57.34  ? 31  TRP A HA   1 
ATOM   452  H HB2  . TRP A 1 31  ? 2.488   31.529  14.105  1.00 63.89  ? 31  TRP A HB2  1 
ATOM   453  H HB3  . TRP A 1 31  ? 1.632   31.622  12.770  1.00 63.89  ? 31  TRP A HB3  1 
ATOM   454  H HD1  . TRP A 1 31  ? 0.395   33.631  15.505  1.00 69.19  ? 31  TRP A HD1  1 
ATOM   455  H HE1  . TRP A 1 31  ? 0.733   35.983  15.116  1.00 69.62  ? 31  TRP A HE1  1 
ATOM   456  H HE3  . TRP A 1 31  ? 3.266   33.376  11.541  1.00 60.49  ? 31  TRP A HE3  1 
ATOM   457  H HZ2  . TRP A 1 31  ? 2.094   37.566  13.295  1.00 74.37  ? 31  TRP A HZ2  1 
ATOM   458  H HZ3  . TRP A 1 31  ? 4.023   35.333  10.565  1.00 65.88  ? 31  TRP A HZ3  1 
ATOM   459  H HH2  . TRP A 1 31  ? 3.442   37.396  11.432  1.00 72.76  ? 31  TRP A HH2  1 
ATOM   460  N N    . LEU A 1 32  ? -1.813  31.646  14.697  1.00 42.78  ? 32  LEU A N    1 
ATOM   461  C CA   . LEU A 1 32  ? -3.155  32.079  14.328  1.00 45.52  ? 32  LEU A CA   1 
ATOM   462  C C    . LEU A 1 32  ? -3.470  33.369  15.071  1.00 53.32  ? 32  LEU A C    1 
ATOM   463  O O    . LEU A 1 32  ? -3.323  33.434  16.296  1.00 50.40  ? 32  LEU A O    1 
ATOM   464  C CB   . LEU A 1 32  ? -4.194  31.009  14.664  1.00 47.56  ? 32  LEU A CB   1 
ATOM   465  C CG   . LEU A 1 32  ? -4.013  29.657  13.976  1.00 51.52  ? 32  LEU A CG   1 
ATOM   466  C CD1  . LEU A 1 32  ? -4.842  28.589  14.673  1.00 48.25  ? 32  LEU A CD1  1 
ATOM   467  C CD2  . LEU A 1 32  ? -4.383  29.746  12.505  1.00 46.54  ? 32  LEU A CD2  1 
ATOM   468  H H    . LEU A 1 32  ? -1.710  31.559  15.547  1.00 51.40  ? 32  LEU A H    1 
ATOM   469  H HA   . LEU A 1 32  ? -3.195  32.247  13.374  1.00 54.68  ? 32  LEU A HA   1 
ATOM   470  H HB2  . LEU A 1 32  ? -4.165  30.850  15.620  1.00 57.13  ? 32  LEU A HB2  1 
ATOM   471  H HB3  . LEU A 1 32  ? -5.067  31.346  14.409  1.00 57.13  ? 32  LEU A HB3  1 
ATOM   472  H HG   . LEU A 1 32  ? -3.080  29.399  14.032  1.00 61.88  ? 32  LEU A HG   1 
ATOM   473  H HD11 . LEU A 1 32  ? -4.697  27.738  14.230  1.00 57.96  ? 32  LEU A HD11 1 
ATOM   474  H HD12 . LEU A 1 32  ? -4.566  28.530  15.601  1.00 57.96  ? 32  LEU A HD12 1 
ATOM   475  H HD13 . LEU A 1 32  ? -5.780  28.833  14.621  1.00 57.96  ? 32  LEU A HD13 1 
ATOM   476  H HD21 . LEU A 1 32  ? -4.272  28.873  12.098  1.00 55.91  ? 32  LEU A HD21 1 
ATOM   477  H HD22 . LEU A 1 32  ? -5.308  30.031  12.429  1.00 55.91  ? 32  LEU A HD22 1 
ATOM   478  H HD23 . LEU A 1 32  ? -3.802  30.390  12.072  1.00 55.91  ? 32  LEU A HD23 1 
ATOM   479  N N    . ASP A 1 33  ? -3.911  34.388  14.334  1.00 51.41  ? 33  ASP A N    1 
ATOM   480  C CA   . ASP A 1 33  ? -4.137  35.726  14.898  1.00 53.02  ? 33  ASP A CA   1 
ATOM   481  C C    . ASP A 1 33  ? -2.865  36.097  15.663  1.00 56.66  ? 33  ASP A C    1 
ATOM   482  O O    . ASP A 1 33  ? -1.765  35.919  15.121  1.00 57.00  ? 33  ASP A O    1 
ATOM   483  C CB   . ASP A 1 33  ? -5.426  35.732  15.712  1.00 50.31  ? 33  ASP A CB   1 
ATOM   484  C CG   . ASP A 1 33  ? -6.642  35.329  14.892  1.00 62.71  ? 33  ASP A CG   1 
ATOM   485  O OD1  . ASP A 1 33  ? -6.853  35.900  13.800  1.00 62.47  ? 33  ASP A OD1  1 
ATOM   486  O OD2  . ASP A 1 33  ? -7.393  34.442  15.347  1.00 66.01  ? 33  ASP A OD2  1 
ATOM   487  H H    . ASP A 1 33  ? -4.090  34.332  13.495  1.00 61.75  ? 33  ASP A H    1 
ATOM   488  H HA   . ASP A 1 33  ? -4.248  36.365  14.177  1.00 63.68  ? 33  ASP A HA   1 
ATOM   489  H HB2  . ASP A 1 33  ? -5.338  35.106  16.447  1.00 60.43  ? 33  ASP A HB2  1 
ATOM   490  H HB3  . ASP A 1 33  ? -5.579  36.627  16.055  1.00 60.43  ? 33  ASP A HB3  1 
ATOM   491  N N    . ASP A 1 34  ? -2.954  36.575  16.906  1.00 55.03  ? 34  ASP A N    1 
ATOM   492  C CA   . ASP A 1 34  ? -1.781  37.005  17.657  1.00 59.10  ? 34  ASP A CA   1 
ATOM   493  C C    . ASP A 1 34  ? -1.330  35.970  18.685  1.00 53.82  ? 34  ASP A C    1 
ATOM   494  O O    . ASP A 1 34  ? -0.832  36.340  19.756  1.00 58.24  ? 34  ASP A O    1 
ATOM   495  C CB   . ASP A 1 34  ? -2.054  38.342  18.347  1.00 58.95  ? 34  ASP A CB   1 
ATOM   496  C CG   . ASP A 1 34  ? -3.175  38.256  19.371  1.00 65.92  ? 34  ASP A CG   1 
ATOM   497  O OD1  . ASP A 1 34  ? -4.119  37.466  19.163  1.00 65.70  ? 34  ASP A OD1  1 
ATOM   498  O OD2  . ASP A 1 34  ? -3.107  38.982  20.385  1.00 66.68  ? 34  ASP A OD2  1 
ATOM   499  H H    . ASP A 1 34  ? -3.694  36.659  17.336  1.00 66.09  ? 34  ASP A H    1 
ATOM   500  H HA   . ASP A 1 34  ? -1.053  37.129  17.028  1.00 70.98  ? 34  ASP A HA   1 
ATOM   501  H HB2  . ASP A 1 34  ? -1.250  38.631  18.806  1.00 70.80  ? 34  ASP A HB2  1 
ATOM   502  H HB3  . ASP A 1 34  ? -2.308  38.997  17.678  1.00 70.80  ? 34  ASP A HB3  1 
ATOM   503  N N    . VAL A 1 35  ? -1.478  34.683  18.376  1.00 49.49  ? 35  VAL A N    1 
ATOM   504  C CA   . VAL A 1 35  ? -1.122  33.614  19.301  1.00 42.92  ? 35  VAL A CA   1 
ATOM   505  C C    . VAL A 1 35  ? -0.369  32.526  18.552  1.00 51.92  ? 35  VAL A C    1 
ATOM   506  O O    . VAL A 1 35  ? -0.728  32.168  17.426  1.00 45.24  ? 35  VAL A O    1 
ATOM   507  C CB   . VAL A 1 35  ? -2.368  33.012  19.987  1.00 48.80  ? 35  VAL A CB   1 
ATOM   508  C CG1  . VAL A 1 35  ? -1.958  31.895  20.938  1.00 51.38  ? 35  VAL A CG1  1 
ATOM   509  C CG2  . VAL A 1 35  ? -3.153  34.086  20.712  1.00 64.31  ? 35  VAL A CG2  1 
ATOM   510  H H    . VAL A 1 35  ? -1.788  34.401  17.625  1.00 59.45  ? 35  VAL A H    1 
ATOM   511  H HA   . VAL A 1 35  ? -0.534  33.984  19.979  1.00 51.57  ? 35  VAL A HA   1 
ATOM   512  H HB   . VAL A 1 35  ? -2.949  32.632  19.310  1.00 58.61  ? 35  VAL A HB   1 
ATOM   513  H HG11 . VAL A 1 35  ? -2.718  31.658  21.492  1.00 61.71  ? 35  VAL A HG11 1 
ATOM   514  H HG12 . VAL A 1 35  ? -1.674  31.127  20.418  1.00 61.71  ? 35  VAL A HG12 1 
ATOM   515  H HG13 . VAL A 1 35  ? -1.227  32.206  21.494  1.00 61.71  ? 35  VAL A HG13 1 
ATOM   516  H HG21 . VAL A 1 35  ? -3.880  33.670  21.202  1.00 77.23  ? 35  VAL A HG21 1 
ATOM   517  H HG22 . VAL A 1 35  ? -2.563  34.549  21.327  1.00 77.23  ? 35  VAL A HG22 1 
ATOM   518  H HG23 . VAL A 1 35  ? -3.509  34.711  20.061  1.00 77.23  ? 35  VAL A HG23 1 
ATOM   519  N N    . VAL A 1 36  ? 0.661   31.982  19.191  1.00 44.03  ? 36  VAL A N    1 
ATOM   520  C CA   . VAL A 1 36  ? 1.402   30.839  18.672  1.00 42.82  ? 36  VAL A CA   1 
ATOM   521  C C    . VAL A 1 36  ? 1.152   29.654  19.592  1.00 48.47  ? 36  VAL A C    1 
ATOM   522  O O    . VAL A 1 36  ? 1.360   29.748  20.807  1.00 46.81  ? 36  VAL A O    1 
ATOM   523  C CB   . VAL A 1 36  ? 2.906   31.139  18.564  1.00 38.60  ? 36  VAL A CB   1 
ATOM   524  C CG1  . VAL A 1 36  ? 3.679   29.857  18.300  1.00 43.21  ? 36  VAL A CG1  1 
ATOM   525  C CG2  . VAL A 1 36  ? 3.159   32.163  17.471  1.00 48.44  ? 36  VAL A CG2  1 
ATOM   526  H H    . VAL A 1 36  ? 0.957   32.266  19.947  1.00 52.89  ? 36  VAL A H    1 
ATOM   527  H HA   . VAL A 1 36  ? 1.072   30.621  17.787  1.00 51.44  ? 36  VAL A HA   1 
ATOM   528  H HB   . VAL A 1 36  ? 3.223   31.512  19.401  1.00 46.38  ? 36  VAL A HB   1 
ATOM   529  H HG11 . VAL A 1 36  ? 4.555   30.083  17.949  1.00 51.91  ? 36  VAL A HG11 1 
ATOM   530  H HG12 . VAL A 1 36  ? 3.773   29.368  19.133  1.00 51.91  ? 36  VAL A HG12 1 
ATOM   531  H HG13 . VAL A 1 36  ? 3.192   29.322  17.655  1.00 51.91  ? 36  VAL A HG13 1 
ATOM   532  H HG21 . VAL A 1 36  ? 4.113   32.317  17.397  1.00 58.19  ? 36  VAL A HG21 1 
ATOM   533  H HG22 . VAL A 1 36  ? 2.814   31.820  16.631  1.00 58.19  ? 36  VAL A HG22 1 
ATOM   534  H HG23 . VAL A 1 36  ? 2.706   32.989  17.701  1.00 58.19  ? 36  VAL A HG23 1 
ATOM   535  N N    . TYR A 1 37  ? 0.699   28.546  19.014  1.00 42.10  ? 37  TYR A N    1 
ATOM   536  C CA   . TYR A 1 37  ? 0.462   27.311  19.748  1.00 39.31  ? 37  TYR A CA   1 
ATOM   537  C C    . TYR A 1 37  ? 1.619   26.355  19.489  1.00 44.64  ? 37  TYR A C    1 
ATOM   538  O O    . TYR A 1 37  ? 2.017   26.160  18.337  1.00 43.77  ? 37  TYR A O    1 
ATOM   539  C CB   . TYR A 1 37  ? -0.857  26.669  19.316  1.00 41.32  ? 37  TYR A CB   1 
ATOM   540  C CG   . TYR A 1 37  ? -2.070  27.557  19.482  1.00 44.77  ? 37  TYR A CG   1 
ATOM   541  C CD1  . TYR A 1 37  ? -2.360  28.550  18.556  1.00 50.10  ? 37  TYR A CD1  1 
ATOM   542  C CD2  . TYR A 1 37  ? -2.931  27.394  20.559  1.00 47.72  ? 37  TYR A CD2  1 
ATOM   543  C CE1  . TYR A 1 37  ? -3.466  29.360  18.700  1.00 52.98  ? 37  TYR A CE1  1 
ATOM   544  C CE2  . TYR A 1 37  ? -4.044  28.202  20.712  1.00 46.27  ? 37  TYR A CE2  1 
ATOM   545  C CZ   . TYR A 1 37  ? -4.305  29.183  19.777  1.00 45.81  ? 37  TYR A CZ   1 
ATOM   546  O OH   . TYR A 1 37  ? -5.406  29.997  19.910  1.00 50.59  ? 37  TYR A OH   1 
ATOM   547  H H    . TYR A 1 37  ? 0.518   28.485  18.175  1.00 50.58  ? 37  TYR A H    1 
ATOM   548  H HA   . TYR A 1 37  ? 0.413   27.495  20.699  1.00 47.23  ? 37  TYR A HA   1 
ATOM   549  H HB2  . TYR A 1 37  ? -0.793  26.433  18.377  1.00 49.65  ? 37  TYR A HB2  1 
ATOM   550  H HB3  . TYR A 1 37  ? -1.002  25.872  19.849  1.00 49.65  ? 37  TYR A HB3  1 
ATOM   551  H HD1  . TYR A 1 37  ? -1.797  28.671  17.825  1.00 60.17  ? 37  TYR A HD1  1 
ATOM   552  H HD2  . TYR A 1 37  ? -2.756  26.732  21.188  1.00 57.32  ? 37  TYR A HD2  1 
ATOM   553  H HE1  . TYR A 1 37  ? -3.645  30.023  18.072  1.00 63.63  ? 37  TYR A HE1  1 
ATOM   554  H HE2  . TYR A 1 37  ? -4.612  28.085  21.439  1.00 55.58  ? 37  TYR A HE2  1 
ATOM   555  H HH   . TYR A 1 37  ? -5.804  29.828  20.630  1.00 60.76  ? 37  TYR A HH   1 
ATOM   556  N N    . CYS A 1 38  ? 2.158   25.763  20.547  1.00 40.16  ? 38  CYS A N    1 
ATOM   557  C CA   . CYS A 1 38  ? 3.235   24.797  20.385  1.00 38.65  ? 38  CYS A CA   1 
ATOM   558  C C    . CYS A 1 38  ? 3.182   23.796  21.526  1.00 40.56  ? 38  CYS A C    1 
ATOM   559  O O    . CYS A 1 38  ? 2.574   24.067  22.569  1.00 40.37  ? 38  CYS A O    1 
ATOM   560  C CB   . CYS A 1 38  ? 4.606   25.485  20.339  1.00 39.19  ? 38  CYS A CB   1 
ATOM   561  S SG   . CYS A 1 38  ? 5.152   26.206  21.897  1.00 45.09  ? 38  CYS A SG   1 
ATOM   562  H H    . CYS A 1 38  ? 1.919   25.903  21.362  1.00 48.25  ? 38  CYS A H    1 
ATOM   563  H HA   . CYS A 1 38  ? 3.104   24.310  19.556  1.00 46.44  ? 38  CYS A HA   1 
ATOM   564  H HB2  . CYS A 1 38  ? 5.270   24.829  20.074  1.00 47.08  ? 38  CYS A HB2  1 
ATOM   565  H HB3  . CYS A 1 38  ? 4.568   26.201  19.685  1.00 47.08  ? 38  CYS A HB3  1 
ATOM   566  H HG   . CYS A 1 38  ? 5.203   25.343  22.730  1.00 54.17  ? 38  CYS A HG   1 
ATOM   567  N N    . PRO A 1 39  ? 3.781   22.617  21.348  1.00 39.78  ? 39  PRO A N    1 
ATOM   568  C CA   . PRO A 1 39  ? 3.849   21.656  22.456  1.00 36.65  ? 39  PRO A CA   1 
ATOM   569  C C    . PRO A 1 39  ? 4.655   22.218  23.615  1.00 41.92  ? 39  PRO A C    1 
ATOM   570  O O    . PRO A 1 39  ? 5.624   22.959  23.429  1.00 35.26  ? 39  PRO A O    1 
ATOM   571  C CB   . PRO A 1 39  ? 4.530   20.433  21.827  1.00 36.06  ? 39  PRO A CB   1 
ATOM   572  C CG   . PRO A 1 39  ? 4.234   20.559  20.346  1.00 31.39  ? 39  PRO A CG   1 
ATOM   573  C CD   . PRO A 1 39  ? 4.283   22.046  20.082  1.00 31.83  ? 39  PRO A CD   1 
ATOM   574  H HA   . PRO A 1 39  ? 2.962   21.408  22.761  1.00 44.04  ? 39  PRO A HA   1 
ATOM   575  H HB2  . PRO A 1 39  ? 5.485   20.460  21.996  1.00 43.33  ? 39  PRO A HB2  1 
ATOM   576  H HB3  . PRO A 1 39  ? 4.152   19.617  22.191  1.00 43.33  ? 39  PRO A HB3  1 
ATOM   577  H HG2  . PRO A 1 39  ? 4.908   20.090  19.830  1.00 37.72  ? 39  PRO A HG2  1 
ATOM   578  H HG3  . PRO A 1 39  ? 3.355   20.199  20.150  1.00 37.72  ? 39  PRO A HG3  1 
ATOM   579  H HD2  . PRO A 1 39  ? 5.192   22.338  19.906  1.00 38.26  ? 39  PRO A HD2  1 
ATOM   580  H HD3  . PRO A 1 39  ? 3.708   22.287  19.340  1.00 38.26  ? 39  PRO A HD3  1 
ATOM   581  N N    . ARG A 1 40  ? 4.242   21.855  24.829  1.00 35.21  ? 40  ARG A N    1 
ATOM   582  C CA   . ARG A 1 40  ? 4.805   22.482  26.014  1.00 38.19  ? 40  ARG A CA   1 
ATOM   583  C C    . ARG A 1 40  ? 6.210   21.994  26.334  1.00 39.43  ? 40  ARG A C    1 
ATOM   584  O O    . ARG A 1 40  ? 6.930   22.678  27.070  1.00 43.08  ? 40  ARG A O    1 
ATOM   585  C CB   . ARG A 1 40  ? 3.885   22.251  27.217  1.00 39.15  ? 40  ARG A CB   1 
ATOM   586  C CG   . ARG A 1 40  ? 3.660   20.798  27.603  1.00 38.16  ? 40  ARG A CG   1 
ATOM   587  C CD   . ARG A 1 40  ? 2.839   20.728  28.884  1.00 40.53  ? 40  ARG A CD   1 
ATOM   588  N NE   . ARG A 1 40  ? 2.594   19.366  29.336  1.00 33.80  ? 40  ARG A NE   1 
ATOM   589  C CZ   . ARG A 1 40  ? 1.950   19.058  30.453  1.00 47.74  ? 40  ARG A CZ   1 
ATOM   590  N NH1  . ARG A 1 40  ? 1.468   19.995  31.251  1.00 36.97  ? 40  ARG A NH1  1 
ATOM   591  N NH2  . ARG A 1 40  ? 1.787   17.779  30.778  1.00 41.76  ? 40  ARG A NH2  1 
ATOM   592  H H    . ARG A 1 40  ? 3.645   21.257  24.987  1.00 42.31  ? 40  ARG A H    1 
ATOM   593  H HA   . ARG A 1 40  ? 4.860   23.439  25.862  1.00 45.88  ? 40  ARG A HA   1 
ATOM   594  H HB2  . ARG A 1 40  ? 4.272   22.697  27.987  1.00 47.04  ? 40  ARG A HB2  1 
ATOM   595  H HB3  . ARG A 1 40  ? 3.017   22.632  27.014  1.00 47.04  ? 40  ARG A HB3  1 
ATOM   596  H HG2  . ARG A 1 40  ? 3.177   20.342  26.896  1.00 45.85  ? 40  ARG A HG2  1 
ATOM   597  H HG3  . ARG A 1 40  ? 4.514   20.363  27.755  1.00 45.85  ? 40  ARG A HG3  1 
ATOM   598  H HD2  . ARG A 1 40  ? 3.314   21.195  29.588  1.00 48.69  ? 40  ARG A HD2  1 
ATOM   599  H HD3  . ARG A 1 40  ? 1.979   21.149  28.729  1.00 48.69  ? 40  ARG A HD3  1 
ATOM   600  H HE   . ARG A 1 40  ? 2.886   18.720  28.848  1.00 40.62  ? 40  ARG A HE   1 
ATOM   601  H HH11 . ARG A 1 40  ? 1.569   20.825  31.050  1.00 44.43  ? 40  ARG A HH11 1 
ATOM   602  H HH12 . ARG A 1 40  ? 1.053   19.775  31.972  1.00 44.43  ? 40  ARG A HH12 1 
ATOM   603  H HH21 . ARG A 1 40  ? 2.098   17.162  30.266  1.00 50.17  ? 40  ARG A HH21 1 
ATOM   604  H HH22 . ARG A 1 40  ? 1.371   17.568  31.501  1.00 50.17  ? 40  ARG A HH22 1 
ATOM   605  N N    . HIS A 1 41  ? 6.628   20.850  25.792  1.00 36.04  ? 41  HIS A N    1 
ATOM   606  C CA   . HIS A 1 41  ? 7.954   20.335  26.114  1.00 40.30  ? 41  HIS A CA   1 
ATOM   607  C C    . HIS A 1 41  ? 9.068   21.106  25.418  1.00 39.44  ? 41  HIS A C    1 
ATOM   608  O O    . HIS A 1 41  ? 10.241  20.779  25.620  1.00 43.64  ? 41  HIS A O    1 
ATOM   609  C CB   . HIS A 1 41  ? 8.044   18.831  25.800  1.00 38.26  ? 41  HIS A CB   1 
ATOM   610  C CG   . HIS A 1 41  ? 8.055   18.484  24.343  1.00 42.65  ? 41  HIS A CG   1 
ATOM   611  N ND1  . HIS A 1 41  ? 6.920   18.096  23.664  1.00 41.70  ? 41  HIS A ND1  1 
ATOM   612  C CD2  . HIS A 1 41  ? 9.071   18.401  23.452  1.00 37.32  ? 41  HIS A CD2  1 
ATOM   613  C CE1  . HIS A 1 41  ? 7.230   17.821  22.410  1.00 39.61  ? 41  HIS A CE1  1 
ATOM   614  N NE2  . HIS A 1 41  ? 8.529   18.001  22.254  1.00 45.64  ? 41  HIS A NE2  1 
ATOM   615  H H    . HIS A 1 41  ? 6.171   20.367  25.247  1.00 43.30  ? 41  HIS A H    1 
ATOM   616  H HA   . HIS A 1 41  ? 8.099   20.421  27.069  1.00 48.42  ? 41  HIS A HA   1 
ATOM   617  H HB2  . HIS A 1 41  ? 8.865   18.486  26.186  1.00 45.97  ? 41  HIS A HB2  1 
ATOM   618  H HB3  . HIS A 1 41  ? 7.279   18.388  26.198  1.00 45.97  ? 41  HIS A HB3  1 
ATOM   619  H HD2  . HIS A 1 41  ? 9.968   18.581  23.619  1.00 44.84  ? 41  HIS A HD2  1 
ATOM   620  H HE1  . HIS A 1 41  ? 6.635   17.548  21.749  1.00 47.58  ? 41  HIS A HE1  1 
ATOM   621  H HE2  . HIS A 1 41  ? 8.965   17.887  21.522  1.00 54.82  ? 41  HIS A HE2  1 
ATOM   622  N N    . VAL A 1 42  ? 8.742   22.142  24.641  1.00 35.39  ? 42  VAL A N    1 
ATOM   623  C CA   . VAL A 1 42  ? 9.780   23.045  24.158  1.00 37.62  ? 42  VAL A CA   1 
ATOM   624  C C    . VAL A 1 42  ? 10.552  23.635  25.331  1.00 48.06  ? 42  VAL A C    1 
ATOM   625  O O    . VAL A 1 42  ? 11.764  23.863  25.233  1.00 42.07  ? 42  VAL A O    1 
ATOM   626  C CB   . VAL A 1 42  ? 9.166   24.150  23.271  1.00 37.93  ? 42  VAL A CB   1 
ATOM   627  C CG1  . VAL A 1 42  ? 8.296   25.077  24.103  1.00 36.13  ? 42  VAL A CG1  1 
ATOM   628  C CG2  . VAL A 1 42  ? 10.264  24.936  22.564  1.00 51.90  ? 42  VAL A CG2  1 
ATOM   629  H H    . VAL A 1 42  ? 7.944   22.338  24.386  1.00 42.52  ? 42  VAL A H    1 
ATOM   630  H HA   . VAL A 1 42  ? 10.401  22.540  23.609  1.00 45.20  ? 42  VAL A HA   1 
ATOM   631  H HB   . VAL A 1 42  ? 8.607   23.737  22.595  1.00 45.58  ? 42  VAL A HB   1 
ATOM   632  H HG11 . VAL A 1 42  ? 7.769   25.633  23.508  1.00 43.41  ? 42  VAL A HG11 1 
ATOM   633  H HG12 . VAL A 1 42  ? 7.711   24.543  24.663  1.00 43.41  ? 42  VAL A HG12 1 
ATOM   634  H HG13 . VAL A 1 42  ? 8.867   25.633  24.656  1.00 43.41  ? 42  VAL A HG13 1 
ATOM   635  H HG21 . VAL A 1 42  ? 9.856   25.563  21.946  1.00 62.34  ? 42  VAL A HG21 1 
ATOM   636  H HG22 . VAL A 1 42  ? 10.785  25.416  23.226  1.00 62.34  ? 42  VAL A HG22 1 
ATOM   637  H HG23 . VAL A 1 42  ? 10.833  24.317  22.080  1.00 62.34  ? 42  VAL A HG23 1 
ATOM   638  N N    . ILE A 1 43  ? 9.872   23.887  26.456  1.00 48.94  ? 43  ILE A N    1 
ATOM   639  C CA   . ILE A 1 43  ? 10.543  24.440  27.631  1.00 51.91  ? 43  ILE A CA   1 
ATOM   640  C C    . ILE A 1 43  ? 11.350  23.403  28.391  1.00 49.08  ? 43  ILE A C    1 
ATOM   641  O O    . ILE A 1 43  ? 11.950  23.732  29.423  1.00 56.82  ? 43  ILE A O    1 
ATOM   642  C CB   . ILE A 1 43  ? 9.557   25.062  28.643  1.00 43.09  ? 43  ILE A CB   1 
ATOM   643  C CG1  . ILE A 1 43  ? 8.828   23.953  29.410  1.00 43.96  ? 43  ILE A CG1  1 
ATOM   644  C CG2  . ILE A 1 43  ? 8.587   25.984  27.937  1.00 48.35  ? 43  ILE A CG2  1 
ATOM   645  C CD1  . ILE A 1 43  ? 7.575   24.415  30.116  1.00 44.43  ? 43  ILE A CD1  1 
ATOM   646  H H    . ILE A 1 43  ? 9.030   23.747  26.561  1.00 58.79  ? 43  ILE A H    1 
ATOM   647  H HA   . ILE A 1 43  ? 11.128  25.136  27.293  1.00 62.35  ? 43  ILE A HA   1 
ATOM   648  H HB   . ILE A 1 43  ? 10.054  25.594  29.284  1.00 51.77  ? 43  ILE A HB   1 
ATOM   649  H HG12 . ILE A 1 43  ? 8.573   23.257  28.783  1.00 52.81  ? 43  ILE A HG12 1 
ATOM   650  H HG13 . ILE A 1 43  ? 9.428   23.592  30.080  1.00 52.81  ? 43  ILE A HG13 1 
ATOM   651  H HG21 . ILE A 1 43  ? 8.171   26.567  28.592  1.00 58.07  ? 43  ILE A HG21 1 
ATOM   652  H HG22 . ILE A 1 43  ? 9.072   26.513  27.284  1.00 58.07  ? 43  ILE A HG22 1 
ATOM   653  H HG23 . ILE A 1 43  ? 7.910   25.450  27.493  1.00 58.07  ? 43  ILE A HG23 1 
ATOM   654  H HD11 . ILE A 1 43  ? 7.303   23.735  30.753  1.00 53.38  ? 43  ILE A HD11 1 
ATOM   655  H HD12 . ILE A 1 43  ? 7.763   25.246  30.580  1.00 53.38  ? 43  ILE A HD12 1 
ATOM   656  H HD13 . ILE A 1 43  ? 6.875   24.553  29.460  1.00 53.38  ? 43  ILE A HD13 1 
ATOM   657  N N    . CYS A 1 44  ? 11.359  22.156  27.936  1.00 45.93  ? 44  CYS A N    1 
ATOM   658  C CA   . CYS A 1 44  ? 12.078  21.107  28.633  1.00 53.84  ? 44  CYS A CA   1 
ATOM   659  C C    . CYS A 1 44  ? 13.556  21.138  28.280  1.00 64.76  ? 44  CYS A C    1 
ATOM   660  O O    . CYS A 1 44  ? 13.952  21.565  27.193  1.00 57.76  ? 44  CYS A O    1 
ATOM   661  C CB   . CYS A 1 44  ? 11.502  19.737  28.281  1.00 48.17  ? 44  CYS A CB   1 
ATOM   662  S SG   . CYS A 1 44  ? 9.980   19.338  29.143  1.00 59.73  ? 44  CYS A SG   1 
ATOM   663  H H    . CYS A 1 44  ? 10.955  21.895  27.223  1.00 55.17  ? 44  CYS A H    1 
ATOM   664  H HA   . CYS A 1 44  ? 11.988  21.242  29.590  1.00 64.66  ? 44  CYS A HA   1 
ATOM   665  H HB2  . CYS A 1 44  ? 11.316  19.714  27.329  1.00 57.86  ? 44  CYS A HB2  1 
ATOM   666  H HB3  . CYS A 1 44  ? 12.156  19.057  28.508  1.00 57.86  ? 44  CYS A HB3  1 
ATOM   667  H HG   . CYS A 1 44  ? 9.626   18.238  28.822  1.00 71.73  ? 44  CYS A HG   1 
ATOM   668  N N    . THR A 1 45  ? 14.373  20.685  29.218  1.00 67.92  ? 45  THR A N    1 
ATOM   669  C CA   . THR A 1 45  ? 15.774  20.389  28.970  1.00 74.90  ? 45  THR A CA   1 
ATOM   670  C C    . THR A 1 45  ? 15.919  18.902  28.669  1.00 79.38  ? 45  THR A C    1 
ATOM   671  O O    . THR A 1 45  ? 15.028  18.099  28.957  1.00 88.67  ? 45  THR A O    1 
ATOM   672  C CB   . THR A 1 45  ? 16.634  20.774  30.172  1.00 70.75  ? 45  THR A CB   1 
ATOM   673  O OG1  . THR A 1 45  ? 16.649  19.692  31.110  1.00 82.11  ? 45  THR A OG1  1 
ATOM   674  C CG2  . THR A 1 45  ? 16.076  22.019  30.845  1.00 56.42  ? 45  THR A CG2  1 
ATOM   675  H H    . THR A 1 45  ? 14.131  20.536  30.030  1.00 81.56  ? 45  THR A H    1 
ATOM   676  H HA   . THR A 1 45  ? 16.095  20.901  28.211  1.00 89.94  ? 45  THR A HA   1 
ATOM   677  H HB   . THR A 1 45  ? 17.540  20.962  29.881  1.00 84.95  ? 45  THR A HB   1 
ATOM   678  H HG1  . THR A 1 45  ? 17.120  19.895  31.775  1.00 98.59  ? 45  THR A HG1  1 
ATOM   679  H HG21 . THR A 1 45  ? 16.734  22.390  31.454  1.00 67.76  ? 45  THR A HG21 1 
ATOM   680  H HG22 . THR A 1 45  ? 15.855  22.686  30.176  1.00 67.76  ? 45  THR A HG22 1 
ATOM   681  H HG23 . THR A 1 45  ? 15.275  21.796  31.344  1.00 67.76  ? 45  THR A HG23 1 
ATOM   682  N N    . SER A 1 46  ? 17.060  18.540  28.082  1.00 72.90  ? 46  SER A N    1 
ATOM   683  C CA   . SER A 1 46  ? 17.301  17.134  27.771  1.00 84.91  ? 46  SER A CA   1 
ATOM   684  C C    . SER A 1 46  ? 17.186  16.265  29.018  1.00 89.49  ? 46  SER A C    1 
ATOM   685  O O    . SER A 1 46  ? 16.695  15.132  28.954  1.00 85.45  ? 46  SER A O    1 
ATOM   686  C CB   . SER A 1 46  ? 18.679  16.968  27.132  1.00 91.73  ? 46  SER A CB   1 
ATOM   687  O OG   . SER A 1 46  ? 19.706  17.267  28.060  1.00 95.29  ? 46  SER A OG   1 
ATOM   688  H H    . SER A 1 46  ? 17.695  19.076  27.859  1.00 87.53  ? 46  SER A H    1 
ATOM   689  H HA   . SER A 1 46  ? 16.634  16.837  27.132  1.00 101.95 ? 46  SER A HA   1 
ATOM   690  H HB2  . SER A 1 46  ? 18.780  16.050  26.834  1.00 110.14 ? 46  SER A HB2  1 
ATOM   691  H HB3  . SER A 1 46  ? 18.751  17.572  26.376  1.00 110.14 ? 46  SER A HB3  1 
ATOM   692  H HG   . SER A 1 46  ? 20.458  17.156  27.702  1.00 114.41 ? 46  SER A HG   1 
ATOM   693  N N    . GLU A 1 47  ? 17.631  16.781  30.165  1.00 89.87  ? 47  GLU A N    1 
ATOM   694  C CA   . GLU A 1 47  ? 17.577  16.007  31.400  1.00 91.12  ? 47  GLU A CA   1 
ATOM   695  C C    . GLU A 1 47  ? 16.189  16.020  32.027  1.00 87.77  ? 47  GLU A C    1 
ATOM   696  O O    . GLU A 1 47  ? 15.795  15.039  32.667  1.00 92.77  ? 47  GLU A O    1 
ATOM   697  C CB   . GLU A 1 47  ? 18.607  16.544  32.397  1.00 72.90  ? 47  GLU A CB   1 
ATOM   698  H H    . GLU A 1 47  ? 17.965  17.568  30.253  1.00 107.90 ? 47  GLU A H    1 
ATOM   699  H HA   . GLU A 1 47  ? 17.803  15.085  31.200  1.00 109.40 ? 47  GLU A HA   1 
ATOM   700  N N    . ASP A 1 48  ? 15.434  17.103  31.847  1.00 77.46  ? 48  ASP A N    1 
ATOM   701  C CA   . ASP A 1 48  ? 14.117  17.240  32.468  1.00 76.08  ? 48  ASP A CA   1 
ATOM   702  C C    . ASP A 1 48  ? 13.020  16.711  31.541  1.00 75.38  ? 48  ASP A C    1 
ATOM   703  O O    . ASP A 1 48  ? 12.077  17.416  31.179  1.00 77.95  ? 48  ASP A O    1 
ATOM   704  C CB   . ASP A 1 48  ? 13.864  18.698  32.840  1.00 71.64  ? 48  ASP A CB   1 
ATOM   705  H H    . ASP A 1 48  ? 15.665  17.777  31.365  1.00 93.01  ? 48  ASP A H    1 
ATOM   706  H HA   . ASP A 1 48  ? 14.104  16.709  33.279  1.00 91.35  ? 48  ASP A HA   1 
ATOM   707  N N    . MET A 1 49  ? 13.152  15.434  31.164  1.00 77.95  ? 49  MET A N    1 
ATOM   708  C CA   . MET A 1 49  ? 12.200  14.805  30.259  1.00 77.13  ? 49  MET A CA   1 
ATOM   709  C C    . MET A 1 49  ? 11.705  13.440  30.728  1.00 59.89  ? 49  MET A C    1 
ATOM   710  O O    . MET A 1 49  ? 10.867  12.839  30.045  1.00 52.76  ? 49  MET A O    1 
ATOM   711  C CB   . MET A 1 49  ? 12.813  14.666  28.853  1.00 78.91  ? 49  MET A CB   1 
ATOM   712  C CG   . MET A 1 49  ? 12.601  15.892  27.963  1.00 67.28  ? 49  MET A CG   1 
ATOM   713  S SD   . MET A 1 49  ? 12.920  15.601  26.209  1.00 72.73  ? 49  MET A SD   1 
ATOM   714  C CE   . MET A 1 49  ? 13.187  17.274  25.616  1.00 63.12  ? 49  MET A CE   1 
ATOM   715  H H    . MET A 1 49  ? 13.787  14.915  31.422  1.00 93.60  ? 49  MET A H    1 
ATOM   716  H HA   . MET A 1 49  ? 11.428  15.389  30.188  1.00 92.61  ? 49  MET A HA   1 
ATOM   717  H HB2  . MET A 1 49  ? 13.769  14.527  28.942  1.00 94.75  ? 49  MET A HB2  1 
ATOM   718  H HB3  . MET A 1 49  ? 12.408  13.905  28.410  1.00 94.75  ? 49  MET A HB3  1 
ATOM   719  H HG2  . MET A 1 49  ? 11.679  16.182  28.049  1.00 80.79  ? 49  MET A HG2  1 
ATOM   720  H HG3  . MET A 1 49  ? 13.199  16.597  28.257  1.00 80.79  ? 49  MET A HG3  1 
ATOM   721  H HE1  . MET A 1 49  ? 13.356  17.247  24.661  1.00 75.80  ? 49  MET A HE1  1 
ATOM   722  H HE2  . MET A 1 49  ? 12.395  17.803  25.797  1.00 75.80  ? 49  MET A HE2  1 
ATOM   723  H HE3  . MET A 1 49  ? 13.952  17.654  26.076  1.00 75.80  ? 49  MET A HE3  1 
ATOM   724  N N    . LEU A 1 50  ? 12.177  12.936  31.872  1.00 68.23  ? 50  LEU A N    1 
ATOM   725  C CA   . LEU A 1 50  ? 11.652  11.673  32.387  1.00 66.25  ? 50  LEU A CA   1 
ATOM   726  C C    . LEU A 1 50  ? 10.329  11.883  33.117  1.00 54.77  ? 50  LEU A C    1 
ATOM   727  O O    . LEU A 1 50  ? 9.368   11.135  32.904  1.00 52.77  ? 50  LEU A O    1 
ATOM   728  C CB   . LEU A 1 50  ? 12.672  11.012  33.313  1.00 69.86  ? 50  LEU A CB   1 
ATOM   729  C CG   . LEU A 1 50  ? 12.321  9.592   33.767  1.00 75.62  ? 50  LEU A CG   1 
ATOM   730  C CD1  . LEU A 1 50  ? 12.156  8.654   32.578  1.00 84.52  ? 50  LEU A CD1  1 
ATOM   731  C CD2  . LEU A 1 50  ? 13.379  9.058   34.728  1.00 72.29  ? 50  LEU A CD2  1 
ATOM   732  H H    . LEU A 1 50  ? 12.787  13.299  32.357  1.00 81.93  ? 50  LEU A H    1 
ATOM   733  H HA   . LEU A 1 50  ? 11.498  11.075  31.639  1.00 79.55  ? 50  LEU A HA   1 
ATOM   734  H HB2  . LEU A 1 50  ? 13.522  10.965  32.847  1.00 83.89  ? 50  LEU A HB2  1 
ATOM   735  H HB3  . LEU A 1 50  ? 12.760  11.558  34.110  1.00 83.89  ? 50  LEU A HB3  1 
ATOM   736  H HG   . LEU A 1 50  ? 11.473  9.622   34.236  1.00 90.80  ? 50  LEU A HG   1 
ATOM   737  H HD11 . LEU A 1 50  ? 12.118  7.740   32.900  1.00 101.49 ? 50  LEU A HD11 1 
ATOM   738  H HD12 . LEU A 1 50  ? 11.333  8.876   32.114  1.00 101.49 ? 50  LEU A HD12 1 
ATOM   739  H HD13 . LEU A 1 50  ? 12.912  8.764   31.981  1.00 101.49 ? 50  LEU A HD13 1 
ATOM   740  H HD21 . LEU A 1 50  ? 13.134  8.160   35.000  1.00 86.80  ? 50  LEU A HD21 1 
ATOM   741  H HD22 . LEU A 1 50  ? 14.237  9.044   34.277  1.00 86.80  ? 50  LEU A HD22 1 
ATOM   742  H HD23 . LEU A 1 50  ? 13.422  9.639   35.504  1.00 86.80  ? 50  LEU A HD23 1 
ATOM   743  N N    . ASN A 1 51  ? 10.265  12.883  33.992  1.00 67.20  ? 51  ASN A N    1 
ATOM   744  C CA   . ASN A 1 51  ? 9.007   13.289  34.621  1.00 62.74  ? 51  ASN A CA   1 
ATOM   745  C C    . ASN A 1 51  ? 9.068   14.783  34.875  1.00 53.68  ? 51  ASN A C    1 
ATOM   746  O O    . ASN A 1 51  ? 9.288   15.237  36.005  1.00 61.78  ? 51  ASN A O    1 
ATOM   747  C CB   . ASN A 1 51  ? 8.744   12.526  35.917  1.00 71.62  ? 51  ASN A CB   1 
ATOM   748  C CG   . ASN A 1 51  ? 7.264   12.476  36.268  1.00 79.24  ? 51  ASN A CG   1 
ATOM   749  O OD1  . ASN A 1 51  ? 6.433   13.079  35.586  1.00 57.58  ? 51  ASN A OD1  1 
ATOM   750  N ND2  . ASN A 1 51  ? 6.929   11.757  37.334  1.00 90.35  ? 51  ASN A ND2  1 
ATOM   751  H H    . ASN A 1 51  ? 10.944  13.348  34.241  1.00 80.70  ? 51  ASN A H    1 
ATOM   752  H HA   . ASN A 1 51  ? 8.272   13.101  34.016  1.00 75.35  ? 51  ASN A HA   1 
ATOM   753  H HB2  . ASN A 1 51  ? 9.062   11.614  35.820  1.00 86.01  ? 51  ASN A HB2  1 
ATOM   754  H HB3  . ASN A 1 51  ? 9.212   12.964  36.645  1.00 86.01  ? 51  ASN A HB3  1 
ATOM   755  H HD21 . ASN A 1 51  ? 7.537   11.350  37.786  1.00 108.47 ? 51  ASN A HD21 1 
ATOM   756  H HD22 . ASN A 1 51  ? 6.105   11.699  37.572  1.00 108.47 ? 51  ASN A HD22 1 
ATOM   757  N N    . PRO A 1 52  ? 8.884   15.588  33.835  1.00 55.73  ? 52  PRO A N    1 
ATOM   758  C CA   . PRO A 1 52  ? 8.938   17.040  34.021  1.00 48.97  ? 52  PRO A CA   1 
ATOM   759  C C    . PRO A 1 52  ? 7.751   17.529  34.830  1.00 51.81  ? 52  PRO A C    1 
ATOM   760  O O    . PRO A 1 52  ? 6.648   16.980  34.755  1.00 46.00  ? 52  PRO A O    1 
ATOM   761  C CB   . PRO A 1 52  ? 8.901   17.595  32.589  1.00 66.06  ? 52  PRO A CB   1 
ATOM   762  C CG   . PRO A 1 52  ? 8.969   16.392  31.666  1.00 67.03  ? 52  PRO A CG   1 
ATOM   763  C CD   . PRO A 1 52  ? 8.504   15.215  32.462  1.00 60.81  ? 52  PRO A CD   1 
ATOM   764  H HA   . PRO A 1 52  ? 9.768   17.306  34.447  1.00 58.83  ? 52  PRO A HA   1 
ATOM   765  H HB2  . PRO A 1 52  ? 8.076   18.086  32.452  1.00 79.33  ? 52  PRO A HB2  1 
ATOM   766  H HB3  . PRO A 1 52  ? 9.662   18.180  32.447  1.00 79.33  ? 52  PRO A HB3  1 
ATOM   767  H HG2  . PRO A 1 52  ? 8.390   16.536  30.902  1.00 80.50  ? 52  PRO A HG2  1 
ATOM   768  H HG3  . PRO A 1 52  ? 9.884   16.262  31.370  1.00 80.50  ? 52  PRO A HG3  1 
ATOM   769  H HD2  . PRO A 1 52  ? 7.544   15.100  32.385  1.00 73.03  ? 52  PRO A HD2  1 
ATOM   770  H HD3  . PRO A 1 52  ? 8.959   14.404  32.184  1.00 73.03  ? 52  PRO A HD3  1 
ATOM   771  N N    . ASN A 1 53  ? 7.994   18.565  35.626  1.00 50.85  ? 53  ASN A N    1 
ATOM   772  C CA   . ASN A 1 53  ? 6.912   19.322  36.245  1.00 47.37  ? 53  ASN A CA   1 
ATOM   773  C C    . ASN A 1 53  ? 6.765   20.590  35.413  1.00 53.54  ? 53  ASN A C    1 
ATOM   774  O O    . ASN A 1 53  ? 7.431   21.599  35.651  1.00 39.33  ? 53  ASN A O    1 
ATOM   775  C CB   . ASN A 1 53  ? 7.175   19.634  37.704  1.00 54.85  ? 53  ASN A CB   1 
ATOM   776  C CG   . ASN A 1 53  ? 5.932   20.141  38.407  1.00 59.26  ? 53  ASN A CG   1 
ATOM   777  O OD1  . ASN A 1 53  ? 5.550   21.302  38.253  1.00 57.72  ? 53  ASN A OD1  1 
ATOM   778  N ND2  . ASN A 1 53  ? 5.272   19.264  39.152  1.00 74.98  ? 53  ASN A ND2  1 
ATOM   779  H H    . ASN A 1 53  ? 8.781   18.849  35.824  1.00 61.07  ? 53  ASN A H    1 
ATOM   780  H HA   . ASN A 1 53  ? 6.095   18.800  36.217  1.00 56.90  ? 53  ASN A HA   1 
ATOM   781  H HB2  . ASN A 1 53  ? 7.470   18.827  38.155  1.00 65.87  ? 53  ASN A HB2  1 
ATOM   782  H HB3  . ASN A 1 53  ? 7.860   20.318  37.766  1.00 65.87  ? 53  ASN A HB3  1 
ATOM   783  H HD21 . ASN A 1 53  ? 5.556   18.455  39.217  1.00 90.03  ? 53  ASN A HD21 1 
ATOM   784  H HD22 . ASN A 1 53  ? 4.560   19.504  39.571  1.00 90.03  ? 53  ASN A HD22 1 
ATOM   785  N N    . TYR A 1 54  ? 5.892   20.520  34.411  1.00 46.10  ? 54  TYR A N    1 
ATOM   786  C CA   . TYR A 1 54  ? 5.759   21.618  33.465  1.00 45.47  ? 54  TYR A CA   1 
ATOM   787  C C    . TYR A 1 54  ? 5.318   22.899  34.152  1.00 43.75  ? 54  TYR A C    1 
ATOM   788  O O    . TYR A 1 54  ? 5.683   23.996  33.711  1.00 39.42  ? 54  TYR A O    1 
ATOM   789  C CB   . TYR A 1 54  ? 4.768   21.226  32.374  1.00 38.39  ? 54  TYR A CB   1 
ATOM   790  C CG   . TYR A 1 54  ? 5.290   20.156  31.446  1.00 40.04  ? 54  TYR A CG   1 
ATOM   791  C CD1  . TYR A 1 54  ? 6.068   20.487  30.345  1.00 42.49  ? 54  TYR A CD1  1 
ATOM   792  C CD2  . TYR A 1 54  ? 5.009   18.813  31.669  1.00 41.90  ? 54  TYR A CD2  1 
ATOM   793  C CE1  . TYR A 1 54  ? 6.547   19.517  29.489  1.00 46.02  ? 54  TYR A CE1  1 
ATOM   794  C CE2  . TYR A 1 54  ? 5.486   17.833  30.817  1.00 48.43  ? 54  TYR A CE2  1 
ATOM   795  C CZ   . TYR A 1 54  ? 6.254   18.191  29.728  1.00 43.54  ? 54  TYR A CZ   1 
ATOM   796  O OH   . TYR A 1 54  ? 6.732   17.222  28.876  1.00 48.14  ? 54  TYR A OH   1 
ATOM   797  H H    . TYR A 1 54  ? 5.371   19.854  34.259  1.00 55.37  ? 54  TYR A H    1 
ATOM   798  H HA   . TYR A 1 54  ? 6.618   21.790  33.050  1.00 54.62  ? 54  TYR A HA   1 
ATOM   799  H HB2  . TYR A 1 54  ? 3.960   20.889  32.791  1.00 46.13  ? 54  TYR A HB2  1 
ATOM   800  H HB3  . TYR A 1 54  ? 4.564   22.009  31.840  1.00 46.13  ? 54  TYR A HB3  1 
ATOM   801  H HD1  . TYR A 1 54  ? 6.270   21.380  30.182  1.00 51.04  ? 54  TYR A HD1  1 
ATOM   802  H HD2  . TYR A 1 54  ? 4.492   18.570  32.402  1.00 50.34  ? 54  TYR A HD2  1 
ATOM   803  H HE1  . TYR A 1 54  ? 7.065   19.756  28.755  1.00 55.28  ? 54  TYR A HE1  1 
ATOM   804  H HE2  . TYR A 1 54  ? 5.290   16.938  30.978  1.00 58.17  ? 54  TYR A HE2  1 
ATOM   805  H HH   . TYR A 1 54  ? 6.482   16.463  29.135  1.00 57.82  ? 54  TYR A HH   1 
ATOM   806  N N    . GLU A 1 55  ? 4.530   22.786  35.222  1.00 43.10  ? 55  GLU A N    1 
ATOM   807  C CA   . GLU A 1 55  ? 4.061   23.978  35.916  1.00 52.28  ? 55  GLU A CA   1 
ATOM   808  C C    . GLU A 1 55  ? 5.224   24.709  36.574  1.00 49.94  ? 55  GLU A C    1 
ATOM   809  O O    . GLU A 1 55  ? 5.265   25.945  36.582  1.00 41.41  ? 55  GLU A O    1 
ATOM   810  C CB   . GLU A 1 55  ? 2.998   23.588  36.943  1.00 64.64  ? 55  GLU A CB   1 
ATOM   811  C CG   . GLU A 1 55  ? 1.796   22.808  36.374  1.00 84.88  ? 55  GLU A CG   1 
ATOM   812  C CD   . GLU A 1 55  ? 2.133   21.376  35.963  1.00 83.53  ? 55  GLU A CD   1 
ATOM   813  O OE1  . GLU A 1 55  ? 1.404   20.801  35.130  1.00 82.67  ? 55  GLU A OE1  1 
ATOM   814  O OE2  . GLU A 1 55  ? 3.144   20.831  36.461  1.00 72.67  ? 55  GLU A OE2  1 
ATOM   815  H H    . GLU A 1 55  ? 4.259   22.043  35.558  1.00 51.78  ? 55  GLU A H    1 
ATOM   816  H HA   . GLU A 1 55  ? 3.649   24.586  35.282  1.00 62.79  ? 55  GLU A HA   1 
ATOM   817  H HB2  . GLU A 1 55  ? 3.414   23.030  37.618  1.00 77.62  ? 55  GLU A HB2  1 
ATOM   818  H HB3  . GLU A 1 55  ? 2.653   24.399  37.349  1.00 77.62  ? 55  GLU A HB3  1 
ATOM   819  H HG2  . GLU A 1 55  ? 1.102   22.767  37.050  1.00 101.92 ? 55  GLU A HG2  1 
ATOM   820  H HG3  . GLU A 1 55  ? 1.467   23.272  35.588  1.00 101.92 ? 55  GLU A HG3  1 
ATOM   821  N N    . ASP A 1 56  ? 6.183   23.955  37.115  1.00 47.93  ? 56  ASP A N    1 
ATOM   822  C CA   . ASP A 1 56  ? 7.394   24.560  37.658  1.00 55.32  ? 56  ASP A CA   1 
ATOM   823  C C    . ASP A 1 56  ? 8.275   25.110  36.545  1.00 59.85  ? 56  ASP A C    1 
ATOM   824  O O    . ASP A 1 56  ? 8.745   26.250  36.613  1.00 45.56  ? 56  ASP A O    1 
ATOM   825  C CB   . ASP A 1 56  ? 8.167   23.526  38.478  1.00 56.22  ? 56  ASP A CB   1 
ATOM   826  C CG   . ASP A 1 56  ? 7.686   23.434  39.907  1.00 54.84  ? 56  ASP A CG   1 
ATOM   827  O OD1  . ASP A 1 56  ? 6.887   24.297  40.326  1.00 58.12  ? 56  ASP A OD1  1 
ATOM   828  O OD2  . ASP A 1 56  ? 8.109   22.495  40.615  1.00 58.69  ? 56  ASP A OD2  1 
ATOM   829  H H    . ASP A 1 56  ? 6.156   23.098  37.180  1.00 57.57  ? 56  ASP A H    1 
ATOM   830  H HA   . ASP A 1 56  ? 7.143   25.292  38.243  1.00 66.44  ? 56  ASP A HA   1 
ATOM   831  H HB2  . ASP A 1 56  ? 8.059   22.653  38.068  1.00 67.53  ? 56  ASP A HB2  1 
ATOM   832  H HB3  . ASP A 1 56  ? 9.105   23.772  38.493  1.00 67.53  ? 56  ASP A HB3  1 
ATOM   833  N N    . LEU A 1 57  ? 8.521   24.302  35.513  1.00 47.48  ? 57  LEU A N    1 
ATOM   834  C CA   . LEU A 1 57  ? 9.394   24.733  34.428  1.00 49.08  ? 57  LEU A CA   1 
ATOM   835  C C    . LEU A 1 57  ? 8.898   26.030  33.803  1.00 47.93  ? 57  LEU A C    1 
ATOM   836  O O    . LEU A 1 57  ? 9.707   26.880  33.411  1.00 45.72  ? 57  LEU A O    1 
ATOM   837  C CB   . LEU A 1 57  ? 9.499   23.633  33.368  1.00 47.65  ? 57  LEU A CB   1 
ATOM   838  C CG   . LEU A 1 57  ? 10.382  22.432  33.720  1.00 52.59  ? 57  LEU A CG   1 
ATOM   839  C CD1  . LEU A 1 57  ? 10.149  21.265  32.762  1.00 52.58  ? 57  LEU A CD1  1 
ATOM   840  C CD2  . LEU A 1 57  ? 11.857  22.817  33.726  1.00 62.27  ? 57  LEU A CD2  1 
ATOM   841  H H    . LEU A 1 57  ? 8.199   23.510  35.419  1.00 57.04  ? 57  LEU A H    1 
ATOM   842  H HA   . LEU A 1 57  ? 10.284  24.890  34.780  1.00 58.95  ? 57  LEU A HA   1 
ATOM   843  H HB2  . LEU A 1 57  ? 8.607   23.291  33.200  1.00 57.24  ? 57  LEU A HB2  1 
ATOM   844  H HB3  . LEU A 1 57  ? 9.861   24.027  32.560  1.00 57.24  ? 57  LEU A HB3  1 
ATOM   845  H HG   . LEU A 1 57  ? 10.139  22.138  34.612  1.00 63.17  ? 57  LEU A HG   1 
ATOM   846  H HD11 . LEU A 1 57  ? 10.722  20.526  33.019  1.00 63.15  ? 57  LEU A HD11 1 
ATOM   847  H HD12 . LEU A 1 57  ? 9.219   20.996  32.813  1.00 63.15  ? 57  LEU A HD12 1 
ATOM   848  H HD13 . LEU A 1 57  ? 10.362  21.551  31.859  1.00 63.15  ? 57  LEU A HD13 1 
ATOM   849  H HD21 . LEU A 1 57  ? 12.391  22.020  33.867  1.00 74.78  ? 57  LEU A HD21 1 
ATOM   850  H HD22 . LEU A 1 57  ? 12.082  23.220  32.873  1.00 74.78  ? 57  LEU A HD22 1 
ATOM   851  H HD23 . LEU A 1 57  ? 12.014  23.451  34.444  1.00 74.78  ? 57  LEU A HD23 1 
ATOM   852  N N    . LEU A 1 58  ? 7.577   26.215  33.729  1.00 46.11  ? 58  LEU A N    1 
ATOM   853  C CA   . LEU A 1 58  ? 7.027   27.396  33.075  1.00 41.72  ? 58  LEU A CA   1 
ATOM   854  C C    . LEU A 1 58  ? 7.088   28.634  33.961  1.00 47.04  ? 58  LEU A C    1 
ATOM   855  O O    . LEU A 1 58  ? 7.241   29.747  33.446  1.00 41.81  ? 58  LEU A O    1 
ATOM   856  C CB   . LEU A 1 58  ? 5.580   27.144  32.650  1.00 43.70  ? 58  LEU A CB   1 
ATOM   857  C CG   . LEU A 1 58  ? 4.982   28.275  31.811  1.00 44.43  ? 58  LEU A CG   1 
ATOM   858  C CD1  . LEU A 1 58  ? 5.767   28.451  30.512  1.00 47.35  ? 58  LEU A CD1  1 
ATOM   859  C CD2  . LEU A 1 58  ? 3.511   28.039  31.515  1.00 51.65  ? 58  LEU A CD2  1 
ATOM   860  H H    . LEU A 1 58  ? 6.987   25.676  34.047  1.00 55.39  ? 58  LEU A H    1 
ATOM   861  H HA   . LEU A 1 58  ? 7.552   27.570  32.278  1.00 50.13  ? 58  LEU A HA   1 
ATOM   862  H HB2  . LEU A 1 58  ? 5.547   26.332  32.120  1.00 52.49  ? 58  LEU A HB2  1 
ATOM   863  H HB3  . LEU A 1 58  ? 5.034   27.043  33.445  1.00 52.49  ? 58  LEU A HB3  1 
ATOM   864  H HG   . LEU A 1 58  ? 5.045   29.096  32.324  1.00 53.38  ? 58  LEU A HG   1 
ATOM   865  H HD11 . LEU A 1 58  ? 5.259   29.018  29.911  1.00 56.88  ? 58  LEU A HD11 1 
ATOM   866  H HD12 . LEU A 1 58  ? 6.622   28.864  30.713  1.00 56.88  ? 58  LEU A HD12 1 
ATOM   867  H HD13 . LEU A 1 58  ? 5.907   27.581  30.108  1.00 56.88  ? 58  LEU A HD13 1 
ATOM   868  H HD21 . LEU A 1 58  ? 3.112   28.871  31.216  1.00 62.03  ? 58  LEU A HD21 1 
ATOM   869  H HD22 . LEU A 1 58  ? 3.433   27.366  30.821  1.00 62.03  ? 58  LEU A HD22 1 
ATOM   870  H HD23 . LEU A 1 58  ? 3.072   27.732  32.324  1.00 62.03  ? 58  LEU A HD23 1 
ATOM   871  N N    . ILE A 1 59  ? 6.954   28.477  35.281  1.00 53.95  ? 59  ILE A N    1 
ATOM   872  C CA   . ILE A 1 59  ? 7.066   29.633  36.163  1.00 56.17  ? 59  ILE A CA   1 
ATOM   873  C C    . ILE A 1 59  ? 8.492   30.169  36.176  1.00 45.16  ? 59  ILE A C    1 
ATOM   874  O O    . ILE A 1 59  ? 8.705   31.348  36.478  1.00 54.59  ? 59  ILE A O    1 
ATOM   875  C CB   . ILE A 1 59  ? 6.564   29.274  37.577  1.00 50.30  ? 59  ILE A CB   1 
ATOM   876  C CG1  . ILE A 1 59  ? 6.315   30.549  38.392  1.00 59.44  ? 59  ILE A CG1  1 
ATOM   877  C CG2  . ILE A 1 59  ? 7.541   28.365  38.307  1.00 52.16  ? 59  ILE A CG2  1 
ATOM   878  C CD1  . ILE A 1 59  ? 5.049   31.284  38.004  1.00 63.67  ? 59  ILE A CD1  1 
ATOM   879  H H    . ILE A 1 59  ? 6.802   27.730  35.678  1.00 64.80  ? 59  ILE A H    1 
ATOM   880  H HA   . ILE A 1 59  ? 6.495   30.346  35.835  1.00 67.46  ? 59  ILE A HA   1 
ATOM   881  H HB   . ILE A 1 59  ? 5.729   28.790  37.476  1.00 60.42  ? 59  ILE A HB   1 
ATOM   882  H HG12 . ILE A 1 59  ? 6.244   30.311  39.329  1.00 71.38  ? 59  ILE A HG12 1 
ATOM   883  H HG13 . ILE A 1 59  ? 7.061   31.155  38.259  1.00 71.38  ? 59  ILE A HG13 1 
ATOM   884  H HG21 . ILE A 1 59  ? 7.317   28.355  39.251  1.00 62.64  ? 59  ILE A HG21 1 
ATOM   885  H HG22 . ILE A 1 59  ? 7.472   27.469  37.941  1.00 62.64  ? 59  ILE A HG22 1 
ATOM   886  H HG23 . ILE A 1 59  ? 8.441   28.705  38.184  1.00 62.64  ? 59  ILE A HG23 1 
ATOM   887  H HD11 . ILE A 1 59  ? 4.917   32.029  38.612  1.00 76.46  ? 59  ILE A HD11 1 
ATOM   888  H HD12 . ILE A 1 59  ? 5.140   31.612  37.095  1.00 76.46  ? 59  ILE A HD12 1 
ATOM   889  H HD13 . ILE A 1 59  ? 4.299   30.673  38.062  1.00 76.46  ? 59  ILE A HD13 1 
ATOM   890  N N    . ARG A 1 60  ? 9.474   29.337  35.838  1.00 47.33  ? 60  ARG A N    1 
ATOM   891  C CA   . ARG A 1 60  ? 10.867  29.756  35.771  1.00 40.75  ? 60  ARG A CA   1 
ATOM   892  C C    . ARG A 1 60  ? 11.239  30.364  34.425  1.00 49.70  ? 60  ARG A C    1 
ATOM   893  O O    . ARG A 1 60  ? 12.412  30.687  34.211  1.00 48.14  ? 60  ARG A O    1 
ATOM   894  C CB   . ARG A 1 60  ? 11.781  28.562  36.070  1.00 44.19  ? 60  ARG A CB   1 
ATOM   895  C CG   . ARG A 1 60  ? 11.772  28.154  37.532  1.00 49.01  ? 60  ARG A CG   1 
ATOM   896  C CD   . ARG A 1 60  ? 12.060  26.676  37.718  1.00 46.39  ? 60  ARG A CD   1 
ATOM   897  N NE   . ARG A 1 60  ? 11.610  26.224  39.030  1.00 44.96  ? 60  ARG A NE   1 
ATOM   898  C CZ   . ARG A 1 60  ? 11.686  24.975  39.465  1.00 55.31  ? 60  ARG A CZ   1 
ATOM   899  N NH1  . ARG A 1 60  ? 12.208  24.014  38.720  1.00 64.76  ? 60  ARG A NH1  1 
ATOM   900  N NH2  . ARG A 1 60  ? 11.225  24.681  40.677  1.00 50.72  ? 60  ARG A NH2  1 
ATOM   901  H H    . ARG A 1 60  ? 9.354   28.509  35.639  1.00 56.86  ? 60  ARG A H    1 
ATOM   902  H HA   . ARG A 1 60  ? 11.023  30.432  36.449  1.00 48.96  ? 60  ARG A HA   1 
ATOM   903  H HB2  . ARG A 1 60  ? 11.485  27.802  35.545  1.00 53.09  ? 60  ARG A HB2  1 
ATOM   904  H HB3  . ARG A 1 60  ? 12.691  28.796  35.830  1.00 53.09  ? 60  ARG A HB3  1 
ATOM   905  H HG2  . ARG A 1 60  ? 12.453  28.656  38.007  1.00 58.87  ? 60  ARG A HG2  1 
ATOM   906  H HG3  . ARG A 1 60  ? 10.899  28.341  37.910  1.00 58.87  ? 60  ARG A HG3  1 
ATOM   907  H HD2  . ARG A 1 60  ? 11.591  26.166  37.039  1.00 55.72  ? 60  ARG A HD2  1 
ATOM   908  H HD3  . ARG A 1 60  ? 13.015  26.520  37.649  1.00 55.72  ? 60  ARG A HD3  1 
ATOM   909  H HE   . ARG A 1 60  ? 11.271  26.811  39.560  1.00 54.01  ? 60  ARG A HE   1 
ATOM   910  H HH11 . ARG A 1 60  ? 12.508  24.194  37.935  1.00 77.77  ? 60  ARG A HH11 1 
ATOM   911  H HH12 . ARG A 1 60  ? 12.248  23.210  39.022  1.00 77.77  ? 60  ARG A HH12 1 
ATOM   912  H HH21 . ARG A 1 60  ? 10.882  25.299  41.168  1.00 60.92  ? 60  ARG A HH21 1 
ATOM   913  H HH22 . ARG A 1 60  ? 11.268  23.874  40.970  1.00 60.92  ? 60  ARG A HH22 1 
ATOM   914  N N    . LYS A 1 61  ? 10.280  30.530  33.522  1.00 54.03  ? 61  LYS A N    1 
ATOM   915  C CA   . LYS A 1 61  ? 10.511  31.146  32.225  1.00 45.42  ? 61  LYS A CA   1 
ATOM   916  C C    . LYS A 1 61  ? 9.817   32.502  32.167  1.00 55.39  ? 61  LYS A C    1 
ATOM   917  O O    . LYS A 1 61  ? 8.940   32.813  32.978  1.00 46.66  ? 61  LYS A O    1 
ATOM   918  C CB   . LYS A 1 61  ? 10.000  30.249  31.091  1.00 52.66  ? 61  LYS A CB   1 
ATOM   919  C CG   . LYS A 1 61  ? 10.669  28.879  31.012  1.00 53.15  ? 61  LYS A CG   1 
ATOM   920  C CD   . LYS A 1 61  ? 11.928  28.914  30.150  1.00 56.43  ? 61  LYS A CD   1 
ATOM   921  C CE   . LYS A 1 61  ? 12.843  27.730  30.438  1.00 50.75  ? 61  LYS A CE   1 
ATOM   922  N NZ   . LYS A 1 61  ? 13.957  28.099  31.359  1.00 74.15  ? 61  LYS A NZ   1 
ATOM   923  H H    . LYS A 1 61  ? 9.464   30.286  33.643  1.00 64.89  ? 61  LYS A H    1 
ATOM   924  H HA   . LYS A 1 61  ? 11.463  31.280  32.094  1.00 54.56  ? 61  LYS A HA   1 
ATOM   925  H HB2  . LYS A 1 61  ? 9.050   30.103  31.217  1.00 63.25  ? 61  LYS A HB2  1 
ATOM   926  H HB3  . LYS A 1 61  ? 10.157  30.700  30.246  1.00 63.25  ? 61  LYS A HB3  1 
ATOM   927  H HG2  . LYS A 1 61  ? 10.920  28.592  31.904  1.00 63.83  ? 61  LYS A HG2  1 
ATOM   928  H HG3  . LYS A 1 61  ? 10.051  28.242  30.620  1.00 63.83  ? 61  LYS A HG3  1 
ATOM   929  H HD2  . LYS A 1 61  ? 11.676  28.882  29.214  1.00 67.77  ? 61  LYS A HD2  1 
ATOM   930  H HD3  . LYS A 1 61  ? 12.419  29.730  30.334  1.00 67.77  ? 61  LYS A HD3  1 
ATOM   931  H HE2  . LYS A 1 61  ? 12.328  27.022  30.854  1.00 60.96  ? 61  LYS A HE2  1 
ATOM   932  H HE3  . LYS A 1 61  ? 13.230  27.415  29.606  1.00 60.96  ? 61  LYS A HE3  1 
ATOM   933  H HZ1  . LYS A 1 61  ? 14.472  27.390  31.512  1.00 89.03  ? 61  LYS A HZ1  1 
ATOM   934  H HZ2  . LYS A 1 61  ? 14.452  28.743  30.995  1.00 89.03  ? 61  LYS A HZ2  1 
ATOM   935  H HZ3  . LYS A 1 61  ? 13.628  28.390  32.133  1.00 89.03  ? 61  LYS A HZ3  1 
ATOM   936  N N    . SER A 1 62  ? 10.227  33.313  31.195  1.00 56.71  ? 62  SER A N    1 
ATOM   937  C CA   . SER A 1 62  ? 9.588   34.593  30.926  1.00 63.42  ? 62  SER A CA   1 
ATOM   938  C C    . SER A 1 62  ? 9.469   34.776  29.419  1.00 62.62  ? 62  SER A C    1 
ATOM   939  O O    . SER A 1 62  ? 10.010  33.996  28.630  1.00 60.78  ? 62  SER A O    1 
ATOM   940  C CB   . SER A 1 62  ? 10.364  35.757  31.554  1.00 56.72  ? 62  SER A CB   1 
ATOM   941  O OG   . SER A 1 62  ? 11.755  35.498  31.558  1.00 77.03  ? 62  SER A OG   1 
ATOM   942  H H    . SER A 1 62  ? 10.885  33.139  30.669  1.00 68.11  ? 62  SER A H    1 
ATOM   943  H HA   . SER A 1 62  ? 8.695   34.591  31.305  1.00 76.16  ? 62  SER A HA   1 
ATOM   944  H HB2  . SER A 1 62  ? 10.195  36.562  31.039  1.00 68.12  ? 62  SER A HB2  1 
ATOM   945  H HB3  . SER A 1 62  ? 10.064  35.879  32.468  1.00 68.12  ? 62  SER A HB3  1 
ATOM   946  H HG   . SER A 1 62  ? 12.162  36.118  31.953  1.00 92.49  ? 62  SER A HG   1 
ATOM   947  N N    . ASN A 1 63  ? 8.753   35.832  29.021  1.00 59.41  ? 63  ASN A N    1 
ATOM   948  C CA   . ASN A 1 63  ? 8.461   36.042  27.607  1.00 58.11  ? 63  ASN A CA   1 
ATOM   949  C C    . ASN A 1 63  ? 9.719   36.041  26.748  1.00 59.96  ? 63  ASN A C    1 
ATOM   950  O O    . ASN A 1 63  ? 9.679   35.608  25.591  1.00 66.21  ? 63  ASN A O    1 
ATOM   951  C CB   . ASN A 1 63  ? 7.705   37.361  27.418  1.00 56.02  ? 63  ASN A CB   1 
ATOM   952  C CG   . ASN A 1 63  ? 6.265   37.281  27.885  1.00 60.49  ? 63  ASN A CG   1 
ATOM   953  O OD1  . ASN A 1 63  ? 5.687   36.198  27.964  1.00 58.74  ? 63  ASN A OD1  1 
ATOM   954  N ND2  . ASN A 1 63  ? 5.679   38.432  28.197  1.00 64.45  ? 63  ASN A ND2  1 
ATOM   955  H H    . ASN A 1 63  ? 8.431   36.433  29.544  1.00 71.35  ? 63  ASN A H    1 
ATOM   956  H HA   . ASN A 1 63  ? 7.895   35.314  27.303  1.00 69.79  ? 63  ASN A HA   1 
ATOM   957  H HB2  . ASN A 1 63  ? 8.149   38.055  27.930  1.00 67.28  ? 63  ASN A HB2  1 
ATOM   958  H HB3  . ASN A 1 63  ? 7.703   37.592  26.476  1.00 67.28  ? 63  ASN A HB3  1 
ATOM   959  H HD21 . ASN A 1 63  ? 4.862   38.439  28.467  1.00 77.40  ? 63  ASN A HD21 1 
ATOM   960  H HD22 . ASN A 1 63  ? 6.115   39.170  28.129  1.00 77.40  ? 63  ASN A HD22 1 
ATOM   961  N N    . HIS A 1 64  ? 10.843  36.516  27.286  1.00 56.50  ? 64  HIS A N    1 
ATOM   962  C CA   . HIS A 1 64  ? 12.052  36.639  26.481  1.00 64.73  ? 64  HIS A CA   1 
ATOM   963  C C    . HIS A 1 64  ? 12.822  35.330  26.354  1.00 62.33  ? 64  HIS A C    1 
ATOM   964  O O    . HIS A 1 64  ? 13.802  35.282  25.602  1.00 57.42  ? 64  HIS A O    1 
ATOM   965  C CB   . HIS A 1 64  ? 12.964  37.723  27.063  1.00 62.30  ? 64  HIS A CB   1 
ATOM   966  C CG   . HIS A 1 64  ? 13.717  37.295  28.282  1.00 70.66  ? 64  HIS A CG   1 
ATOM   967  N ND1  . HIS A 1 64  ? 14.909  36.609  28.218  1.00 71.88  ? 64  HIS A ND1  1 
ATOM   968  C CD2  . HIS A 1 64  ? 13.450  37.464  29.599  1.00 71.45  ? 64  HIS A CD2  1 
ATOM   969  C CE1  . HIS A 1 64  ? 15.343  36.369  29.442  1.00 71.27  ? 64  HIS A CE1  1 
ATOM   970  N NE2  . HIS A 1 64  ? 14.476  36.877  30.298  1.00 70.69  ? 64  HIS A NE2  1 
ATOM   971  H H    . HIS A 1 64  ? 10.927  36.770  28.104  1.00 67.85  ? 64  HIS A H    1 
ATOM   972  H HA   . HIS A 1 64  ? 11.799  36.914  25.586  1.00 77.73  ? 64  HIS A HA   1 
ATOM   973  H HB2  . HIS A 1 64  ? 13.614  37.977  26.389  1.00 74.82  ? 64  HIS A HB2  1 
ATOM   974  H HB3  . HIS A 1 64  ? 12.421  38.489  27.305  1.00 74.82  ? 64  HIS A HB3  1 
ATOM   975  H HD2  . HIS A 1 64  ? 12.711  37.897  29.961  1.00 85.79  ? 64  HIS A HD2  1 
ATOM   976  H HE1  . HIS A 1 64  ? 16.126  35.918  29.663  1.00 85.58  ? 64  HIS A HE1  1 
ATOM   977  H HE2  . HIS A 1 64  ? 14.543  36.846  31.155  1.00 84.89  ? 64  HIS A HE2  1 
ATOM   978  N N    . ASN A 1 65  ? 12.411  34.275  27.060  1.00 62.20  ? 65  ASN A N    1 
ATOM   979  C CA   . ASN A 1 65  ? 13.030  32.970  26.872  1.00 63.44  ? 65  ASN A CA   1 
ATOM   980  C C    . ASN A 1 65  ? 12.529  32.266  25.618  1.00 56.53  ? 65  ASN A C    1 
ATOM   981  O O    . ASN A 1 65  ? 13.153  31.294  25.177  1.00 55.56  ? 65  ASN A O    1 
ATOM   982  C CB   . ASN A 1 65  ? 12.768  32.072  28.084  1.00 73.73  ? 65  ASN A CB   1 
ATOM   983  C CG   . ASN A 1 65  ? 13.559  32.492  29.303  1.00 60.93  ? 65  ASN A CG   1 
ATOM   984  O OD1  . ASN A 1 65  ? 12.988  32.814  30.345  1.00 51.62  ? 65  ASN A OD1  1 
ATOM   985  N ND2  . ASN A 1 65  ? 14.882  32.488  29.183  1.00 53.93  ? 65  ASN A ND2  1 
ATOM   986  H H    . ASN A 1 65  ? 11.782  34.292  27.646  1.00 74.70  ? 65  ASN A H    1 
ATOM   987  H HA   . ASN A 1 65  ? 13.989  33.096  26.795  1.00 76.19  ? 65  ASN A HA   1 
ATOM   988  H HB2  . ASN A 1 65  ? 11.826  32.111  28.309  1.00 88.54  ? 65  ASN A HB2  1 
ATOM   989  H HB3  . ASN A 1 65  ? 13.019  31.161  27.863  1.00 88.54  ? 65  ASN A HB3  1 
ATOM   990  H HD21 . ASN A 1 65  ? 15.375  32.720  29.849  1.00 64.77  ? 65  ASN A HD21 1 
ATOM   991  H HD22 . ASN A 1 65  ? 15.245  32.255  28.440  1.00 64.77  ? 65  ASN A HD22 1 
ATOM   992  N N    . PHE A 1 66  ? 11.420  32.725  25.042  1.00 51.24  ? 66  PHE A N    1 
ATOM   993  C CA   . PHE A 1 66  ? 10.817  32.095  23.875  1.00 56.08  ? 66  PHE A CA   1 
ATOM   994  C C    . PHE A 1 66  ? 11.195  32.882  22.627  1.00 60.64  ? 66  PHE A C    1 
ATOM   995  O O    . PHE A 1 66  ? 10.871  34.069  22.512  1.00 53.80  ? 66  PHE A O    1 
ATOM   996  C CB   . PHE A 1 66  ? 9.298   32.020  24.016  1.00 56.05  ? 66  PHE A CB   1 
ATOM   997  C CG   . PHE A 1 66  ? 8.842   31.230  25.206  1.00 53.37  ? 66  PHE A CG   1 
ATOM   998  C CD1  . PHE A 1 66  ? 8.823   29.846  25.170  1.00 49.43  ? 66  PHE A CD1  1 
ATOM   999  C CD2  . PHE A 1 66  ? 8.434   31.872  26.363  1.00 57.60  ? 66  PHE A CD2  1 
ATOM   1000 C CE1  . PHE A 1 66  ? 8.405   29.118  26.265  1.00 54.45  ? 66  PHE A CE1  1 
ATOM   1001 C CE2  . PHE A 1 66  ? 8.016   31.148  27.461  1.00 44.24  ? 66  PHE A CE2  1 
ATOM   1002 C CZ   . PHE A 1 66  ? 8.002   29.769  27.412  1.00 52.21  ? 66  PHE A CZ   1 
ATOM   1003 H H    . PHE A 1 66  ? 10.990  33.417  25.318  1.00 61.54  ? 66  PHE A H    1 
ATOM   1004 H HA   . PHE A 1 66  ? 11.164  31.193  23.786  1.00 67.36  ? 66  PHE A HA   1 
ATOM   1005 H HB2  . PHE A 1 66  ? 8.948   32.920  24.106  1.00 67.32  ? 66  PHE A HB2  1 
ATOM   1006 H HB3  . PHE A 1 66  ? 8.931   31.599  23.223  1.00 67.32  ? 66  PHE A HB3  1 
ATOM   1007 H HD1  . PHE A 1 66  ? 9.095   29.403  24.399  1.00 59.37  ? 66  PHE A HD1  1 
ATOM   1008 H HD2  . PHE A 1 66  ? 8.441   32.801  26.400  1.00 69.17  ? 66  PHE A HD2  1 
ATOM   1009 H HE1  . PHE A 1 66  ? 8.396   28.188  26.230  1.00 65.40  ? 66  PHE A HE1  1 
ATOM   1010 H HE2  . PHE A 1 66  ? 7.744   31.589  28.233  1.00 53.15  ? 66  PHE A HE2  1 
ATOM   1011 H HZ   . PHE A 1 66  ? 7.720   29.280  28.151  1.00 62.70  ? 66  PHE A HZ   1 
ATOM   1012 N N    . LEU A 1 67  ? 11.869  32.219  21.697  1.00 54.34  ? 67  LEU A N    1 
ATOM   1013 C CA   . LEU A 1 67  ? 12.291  32.817  20.436  1.00 58.05  ? 67  LEU A CA   1 
ATOM   1014 C C    . LEU A 1 67  ? 11.389  32.262  19.340  1.00 57.00  ? 67  LEU A C    1 
ATOM   1015 O O    . LEU A 1 67  ? 11.438  31.065  19.034  1.00 47.86  ? 67  LEU A O    1 
ATOM   1016 C CB   . LEU A 1 67  ? 13.763  32.519  20.177  1.00 66.89  ? 67  LEU A CB   1 
ATOM   1017 C CG   . LEU A 1 67  ? 14.345  32.786  18.793  1.00 75.67  ? 67  LEU A CG   1 
ATOM   1018 C CD1  . LEU A 1 67  ? 14.303  34.257  18.446  1.00 75.60  ? 67  LEU A CD1  1 
ATOM   1019 C CD2  . LEU A 1 67  ? 15.777  32.255  18.756  1.00 83.17  ? 67  LEU A CD2  1 
ATOM   1020 H H    . LEU A 1 67  ? 12.101  31.395  21.776  1.00 65.26  ? 67  LEU A H    1 
ATOM   1021 H HA   . LEU A 1 67  ? 12.181  33.781  20.457  1.00 69.71  ? 67  LEU A HA   1 
ATOM   1022 H HB2  . LEU A 1 67  ? 14.281  33.055  20.799  1.00 80.32  ? 67  LEU A HB2  1 
ATOM   1023 H HB3  . LEU A 1 67  ? 13.903  31.576  20.355  1.00 80.32  ? 67  LEU A HB3  1 
ATOM   1024 H HG   . LEU A 1 67  ? 13.813  32.331  18.122  1.00 90.86  ? 67  LEU A HG   1 
ATOM   1025 H HD11 . LEU A 1 67  ? 14.692  34.386  17.567  1.00 90.78  ? 67  LEU A HD11 1 
ATOM   1026 H HD12 . LEU A 1 67  ? 13.380  34.556  18.446  1.00 90.78  ? 67  LEU A HD12 1 
ATOM   1027 H HD13 . LEU A 1 67  ? 14.811  34.753  19.108  1.00 90.78  ? 67  LEU A HD13 1 
ATOM   1028 H HD21 . LEU A 1 67  ? 16.156  32.430  17.881  1.00 99.86  ? 67  LEU A HD21 1 
ATOM   1029 H HD22 . LEU A 1 67  ? 16.299  32.706  19.438  1.00 99.86  ? 67  LEU A HD22 1 
ATOM   1030 H HD23 . LEU A 1 67  ? 15.764  31.300  18.927  1.00 99.86  ? 67  LEU A HD23 1 
ATOM   1031 N N    . VAL A 1 68  ? 10.556  33.131  18.770  1.00 50.51  ? 68  VAL A N    1 
ATOM   1032 C CA   . VAL A 1 68  ? 9.589   32.769  17.739  1.00 56.69  ? 68  VAL A CA   1 
ATOM   1033 C C    . VAL A 1 68  ? 9.999   33.452  16.444  1.00 61.14  ? 68  VAL A C    1 
ATOM   1034 O O    . VAL A 1 68  ? 10.166  34.678  16.407  1.00 56.83  ? 68  VAL A O    1 
ATOM   1035 C CB   . VAL A 1 68  ? 8.160   33.174  18.142  1.00 66.20  ? 68  VAL A CB   1 
ATOM   1036 C CG1  . VAL A 1 68  ? 7.159   32.763  17.069  1.00 57.76  ? 68  VAL A CG1  1 
ATOM   1037 C CG2  . VAL A 1 68  ? 7.797   32.563  19.487  1.00 60.15  ? 68  VAL A CG2  1 
ATOM   1038 H H    . VAL A 1 68  ? 10.533  33.967  18.973  1.00 60.67  ? 68  VAL A H    1 
ATOM   1039 H HA   . VAL A 1 68  ? 9.608   31.809  17.603  1.00 68.09  ? 68  VAL A HA   1 
ATOM   1040 H HB   . VAL A 1 68  ? 8.119   34.140  18.228  1.00 79.50  ? 68  VAL A HB   1 
ATOM   1041 H HG11 . VAL A 1 68  ? 6.260   32.933  17.394  1.00 69.37  ? 68  VAL A HG11 1 
ATOM   1042 H HG12 . VAL A 1 68  ? 7.324   33.283  16.267  1.00 69.37  ? 68  VAL A HG12 1 
ATOM   1043 H HG13 . VAL A 1 68  ? 7.269   31.818  16.880  1.00 69.37  ? 68  VAL A HG13 1 
ATOM   1044 H HG21 . VAL A 1 68  ? 6.870   32.765  19.685  1.00 72.24  ? 68  VAL A HG21 1 
ATOM   1045 H HG22 . VAL A 1 68  ? 7.924   31.602  19.441  1.00 72.24  ? 68  VAL A HG22 1 
ATOM   1046 H HG23 . VAL A 1 68  ? 8.372   32.941  20.171  1.00 72.24  ? 68  VAL A HG23 1 
ATOM   1047 N N    . GLN A 1 69  ? 10.145  32.665  15.380  1.00 62.72  ? 69  GLN A N    1 
ATOM   1048 C CA   . GLN A 1 69  ? 10.625  33.160  14.094  1.00 71.42  ? 69  GLN A CA   1 
ATOM   1049 C C    . GLN A 1 69  ? 9.682   32.691  12.994  1.00 60.02  ? 69  GLN A C    1 
ATOM   1050 O O    . GLN A 1 69  ? 9.580   31.488  12.728  1.00 61.50  ? 69  GLN A O    1 
ATOM   1051 C CB   . GLN A 1 69  ? 12.053  32.679  13.826  1.00 77.17  ? 69  GLN A CB   1 
ATOM   1052 C CG   . GLN A 1 69  ? 13.086  33.247  14.786  1.00 83.55  ? 69  GLN A CG   1 
ATOM   1053 C CD   . GLN A 1 69  ? 14.488  32.744  14.502  1.00 91.38  ? 69  GLN A CD   1 
ATOM   1054 O OE1  . GLN A 1 69  ? 15.166  33.243  13.603  1.00 70.17  ? 69  GLN A OE1  1 
ATOM   1055 N NE2  . GLN A 1 69  ? 14.931  31.755  15.268  1.00 83.77  ? 69  GLN A NE2  1 
ATOM   1056 H H    . GLN A 1 69  ? 9.967   31.823  15.379  1.00 75.32  ? 69  GLN A H    1 
ATOM   1057 H HA   . GLN A 1 69  ? 10.613  34.130  14.102  1.00 85.76  ? 69  GLN A HA   1 
ATOM   1058 H HB2  . GLN A 1 69  ? 12.076  31.713  13.906  1.00 92.66  ? 69  GLN A HB2  1 
ATOM   1059 H HB3  . GLN A 1 69  ? 12.307  32.944  12.929  1.00 92.66  ? 69  GLN A HB3  1 
ATOM   1060 H HG2  . GLN A 1 69  ? 13.093  34.213  14.709  1.00 100.32 ? 69  GLN A HG2  1 
ATOM   1061 H HG3  . GLN A 1 69  ? 12.853  32.988  15.692  1.00 100.32 ? 69  GLN A HG3  1 
ATOM   1062 H HE21 . GLN A 1 69  ? 14.429  31.433  15.888  1.00 100.59 ? 69  GLN A HE21 1 
ATOM   1063 H HE22 . GLN A 1 69  ? 15.720  31.436  15.145  1.00 100.59 ? 69  GLN A HE22 1 
ATOM   1064 N N    . ALA A 1 70  ? 8.987   33.638  12.365  1.00 60.06  ? 70  ALA A N    1 
ATOM   1065 C CA   . ALA A 1 70  ? 8.162   33.360  11.190  1.00 66.91  ? 70  ALA A CA   1 
ATOM   1066 C C    . ALA A 1 70  ? 9.044   33.592  9.969   1.00 71.60  ? 70  ALA A C    1 
ATOM   1067 O O    . ALA A 1 70  ? 9.271   34.733  9.561   1.00 68.66  ? 70  ALA A O    1 
ATOM   1068 C CB   . ALA A 1 70  ? 6.921   34.242  11.170  1.00 63.36  ? 70  ALA A CB   1 
ATOM   1069 H H    . ALA A 1 70  ? 8.977   34.464  12.603  1.00 72.12  ? 70  ALA A H    1 
ATOM   1070 H HA   . ALA A 1 70  ? 7.863   32.437  11.200  1.00 80.35  ? 70  ALA A HA   1 
ATOM   1071 H HB1  . ALA A 1 70  ? 6.397   34.033  10.382  1.00 76.09  ? 70  ALA A HB1  1 
ATOM   1072 H HB2  . ALA A 1 70  ? 6.399   34.071  11.970  1.00 76.09  ? 70  ALA A HB2  1 
ATOM   1073 H HB3  . ALA A 1 70  ? 7.196   35.173  11.148  1.00 76.09  ? 70  ALA A HB3  1 
ATOM   1074 N N    . GLY A 1 71  ? 9.551   32.508  9.390   1.00 81.39  ? 71  GLY A N    1 
ATOM   1075 C CA   . GLY A 1 71  ? 10.572  32.623  8.371   1.00 87.18  ? 71  GLY A CA   1 
ATOM   1076 C C    . GLY A 1 71  ? 11.871  33.097  8.988   1.00 85.14  ? 71  GLY A C    1 
ATOM   1077 O O    . GLY A 1 71  ? 12.485  32.376  9.780   1.00 87.96  ? 71  GLY A O    1 
ATOM   1078 H H    . GLY A 1 71  ? 9.319   31.701  9.573   1.00 97.73  ? 71  GLY A H    1 
ATOM   1079 H HA2  . GLY A 1 71  ? 10.718  31.761  7.951   1.00 104.67 ? 71  GLY A HA2  1 
ATOM   1080 H HA3  . GLY A 1 71  ? 10.293  33.260  7.695   1.00 104.67 ? 71  GLY A HA3  1 
ATOM   1081 N N    . ASN A 1 72  ? 12.297  34.310  8.639   1.00 86.21  ? 72  ASN A N    1 
ATOM   1082 C CA   . ASN A 1 72  ? 13.432  34.956  9.282   1.00 91.31  ? 72  ASN A CA   1 
ATOM   1083 C C    . ASN A 1 72  ? 13.017  36.166  10.108  1.00 103.89 ? 72  ASN A C    1 
ATOM   1084 O O    . ASN A 1 72  ? 13.875  36.794  10.740  1.00 112.03 ? 72  ASN A O    1 
ATOM   1085 C CB   . ASN A 1 72  ? 14.468  35.374  8.233   1.00 90.59  ? 72  ASN A CB   1 
ATOM   1086 H H    . ASN A 1 72  ? 11.936  34.786  8.021   1.00 103.51 ? 72  ASN A H    1 
ATOM   1087 H HA   . ASN A 1 72  ? 13.861  34.319  9.876   1.00 109.63 ? 72  ASN A HA   1 
ATOM   1088 N N    . VAL A 1 73  ? 11.732  36.510  10.115  1.00 87.89  ? 73  VAL A N    1 
ATOM   1089 C CA   . VAL A 1 73  ? 11.229  37.603  10.940  1.00 77.59  ? 73  VAL A CA   1 
ATOM   1090 C C    . VAL A 1 73  ? 10.996  37.084  12.351  1.00 77.58  ? 73  VAL A C    1 
ATOM   1091 O O    . VAL A 1 73  ? 10.283  36.092  12.552  1.00 71.52  ? 73  VAL A O    1 
ATOM   1092 C CB   . VAL A 1 73  ? 9.936   38.180  10.339  1.00 69.30  ? 73  VAL A CB   1 
ATOM   1093 C CG1  . VAL A 1 73  ? 9.304   39.197  11.282  1.00 76.75  ? 73  VAL A CG1  1 
ATOM   1094 C CG2  . VAL A 1 73  ? 10.217  38.812  8.982   1.00 78.81  ? 73  VAL A CG2  1 
ATOM   1095 H H    . VAL A 1 73  ? 11.125  36.122  9.645   1.00 105.52 ? 73  VAL A H    1 
ATOM   1096 H HA   . VAL A 1 73  ? 11.891  38.311  10.979  1.00 93.17  ? 73  VAL A HA   1 
ATOM   1097 H HB   . VAL A 1 73  ? 9.302   37.456  10.214  1.00 83.22  ? 73  VAL A HB   1 
ATOM   1098 H HG11 . VAL A 1 73  ? 8.512   39.568  10.863  1.00 92.16  ? 73  VAL A HG11 1 
ATOM   1099 H HG12 . VAL A 1 73  ? 9.062   38.752  12.110  1.00 92.16  ? 73  VAL A HG12 1 
ATOM   1100 H HG13 . VAL A 1 73  ? 9.945   39.903  11.461  1.00 92.16  ? 73  VAL A HG13 1 
ATOM   1101 H HG21 . VAL A 1 73  ? 9.389   39.169  8.623   1.00 94.63  ? 73  VAL A HG21 1 
ATOM   1102 H HG22 . VAL A 1 73  ? 10.864  39.526  9.094   1.00 94.63  ? 73  VAL A HG22 1 
ATOM   1103 H HG23 . VAL A 1 73  ? 10.571  38.134  8.386   1.00 94.63  ? 73  VAL A HG23 1 
ATOM   1104 N N    . GLN A 1 74  ? 11.599  37.749  13.333  1.00 87.46  ? 74  GLN A N    1 
ATOM   1105 C CA   . GLN A 1 74  ? 11.418  37.371  14.728  1.00 76.56  ? 74  GLN A CA   1 
ATOM   1106 C C    . GLN A 1 74  ? 10.138  37.993  15.273  1.00 72.06  ? 74  GLN A C    1 
ATOM   1107 O O    . GLN A 1 74  ? 9.926   39.204  15.150  1.00 72.78  ? 74  GLN A O    1 
ATOM   1108 C CB   . GLN A 1 74  ? 12.619  37.818  15.562  1.00 69.44  ? 74  GLN A CB   1 
ATOM   1109 H H    . GLN A 1 74  ? 12.117  38.425  13.216  1.00 105.01 ? 74  GLN A H    1 
ATOM   1110 H HA   . GLN A 1 74  ? 11.346  36.406  14.794  1.00 91.93  ? 74  GLN A HA   1 
ATOM   1111 N N    . LEU A 1 75  ? 9.283   37.163  15.868  1.00 73.55  ? 75  LEU A N    1 
ATOM   1112 C CA   . LEU A 1 75  ? 8.048   37.619  16.491  1.00 69.73  ? 75  LEU A CA   1 
ATOM   1113 C C    . LEU A 1 75  ? 8.266   37.746  17.994  1.00 70.42  ? 75  LEU A C    1 
ATOM   1114 O O    . LEU A 1 75  ? 8.801   36.831  18.630  1.00 69.37  ? 75  LEU A O    1 
ATOM   1115 C CB   . LEU A 1 75  ? 6.893   36.660  16.203  1.00 66.58  ? 75  LEU A CB   1 
ATOM   1116 C CG   . LEU A 1 75  ? 6.547   36.417  14.734  1.00 65.97  ? 75  LEU A CG   1 
ATOM   1117 C CD1  . LEU A 1 75  ? 5.363   35.463  14.609  1.00 67.30  ? 75  LEU A CD1  1 
ATOM   1118 C CD2  . LEU A 1 75  ? 6.254   37.725  14.015  1.00 65.34  ? 75  LEU A CD2  1 
ATOM   1119 H H    . LEU A 1 75  ? 9.402   36.313  15.924  1.00 88.32  ? 75  LEU A H    1 
ATOM   1120 H HA   . LEU A 1 75  ? 7.807   38.488  16.135  1.00 83.73  ? 75  LEU A HA   1 
ATOM   1121 H HB2  . LEU A 1 75  ? 7.118   35.798  16.587  1.00 79.95  ? 75  LEU A HB2  1 
ATOM   1122 H HB3  . LEU A 1 75  ? 6.097   37.015  16.627  1.00 79.95  ? 75  LEU A HB3  1 
ATOM   1123 H HG   . LEU A 1 75  ? 7.313   36.008  14.303  1.00 79.22  ? 75  LEU A HG   1 
ATOM   1124 H HD11 . LEU A 1 75  ? 5.173   35.317  13.669  1.00 80.82  ? 75  LEU A HD11 1 
ATOM   1125 H HD12 . LEU A 1 75  ? 5.590   34.622  15.035  1.00 80.82  ? 75  LEU A HD12 1 
ATOM   1126 H HD13 . LEU A 1 75  ? 4.592   35.858  15.045  1.00 80.82  ? 75  LEU A HD13 1 
ATOM   1127 H HD21 . LEU A 1 75  ? 5.945   37.529  13.116  1.00 78.47  ? 75  LEU A HD21 1 
ATOM   1128 H HD22 . LEU A 1 75  ? 5.568   38.206  14.503  1.00 78.47  ? 75  LEU A HD22 1 
ATOM   1129 H HD23 . LEU A 1 75  ? 7.066   38.253  13.978  1.00 78.47  ? 75  LEU A HD23 1 
ATOM   1130 N N    . ARG A 1 76  ? 7.844   38.873  18.555  1.00 67.26  ? 76  ARG A N    1 
ATOM   1131 C CA   . ARG A 1 76  ? 8.119   39.208  19.946  1.00 74.81  ? 76  ARG A CA   1 
ATOM   1132 C C    . ARG A 1 76  ? 7.011   38.668  20.838  1.00 69.54  ? 76  ARG A C    1 
ATOM   1133 O O    . ARG A 1 76  ? 5.841   39.029  20.674  1.00 59.50  ? 76  ARG A O    1 
ATOM   1134 C CB   . ARG A 1 76  ? 8.252   40.723  20.093  1.00 76.85  ? 76  ARG A CB   1 
ATOM   1135 C CG   . ARG A 1 76  ? 8.700   41.201  21.455  1.00 81.73  ? 76  ARG A CG   1 
ATOM   1136 C CD   . ARG A 1 76  ? 8.691   42.721  21.501  1.00 91.31  ? 76  ARG A CD   1 
ATOM   1137 N NE   . ARG A 1 76  ? 7.754   43.236  22.492  1.00 92.97  ? 76  ARG A NE   1 
ATOM   1138 C CZ   . ARG A 1 76  ? 8.103   43.681  23.691  1.00 89.18  ? 76  ARG A CZ   1 
ATOM   1139 N NH1  . ARG A 1 76  ? 9.366   43.694  24.085  1.00 91.90  ? 76  ARG A NH1  1 
ATOM   1140 N NH2  . ARG A 1 76  ? 7.160   44.127  24.516  1.00 94.36  ? 76  ARG A NH2  1 
ATOM   1141 H H    . ARG A 1 76  ? 7.386   39.473  18.141  1.00 80.76  ? 76  ARG A H    1 
ATOM   1142 H HA   . ARG A 1 76  ? 8.949   38.791  20.227  1.00 89.83  ? 76  ARG A HA   1 
ATOM   1143 H HB2  . ARG A 1 76  ? 8.903   41.038  19.447  1.00 92.27  ? 76  ARG A HB2  1 
ATOM   1144 H HB3  . ARG A 1 76  ? 7.387   41.124  19.915  1.00 92.27  ? 76  ARG A HB3  1 
ATOM   1145 H HG2  . ARG A 1 76  ? 8.095   40.865  22.135  1.00 98.13  ? 76  ARG A HG2  1 
ATOM   1146 H HG3  . ARG A 1 76  ? 9.601   40.889  21.630  1.00 98.13  ? 76  ARG A HG3  1 
ATOM   1147 H HD2  . ARG A 1 76  ? 9.579   43.038  21.731  1.00 109.63 ? 76  ARG A HD2  1 
ATOM   1148 H HD3  . ARG A 1 76  ? 8.431   43.065  20.632  1.00 109.63 ? 76  ARG A HD3  1 
ATOM   1149 H HE   . ARG A 1 76  ? 6.920   43.251  22.285  1.00 111.63 ? 76  ARG A HE   1 
ATOM   1150 H HH11 . ARG A 1 76  ? 9.983   43.409  23.558  1.00 110.34 ? 76  ARG A HH11 1 
ATOM   1151 H HH12 . ARG A 1 76  ? 9.570   43.987  24.867  1.00 110.34 ? 76  ARG A HH12 1 
ATOM   1152 H HH21 . ARG A 1 76  ? 6.336   44.125  24.270  1.00 113.29 ? 76  ARG A HH21 1 
ATOM   1153 H HH22 . ARG A 1 76  ? 7.375   44.418  25.297  1.00 113.29 ? 76  ARG A HH22 1 
ATOM   1154 N N    . VAL A 1 77  ? 7.379   37.804  21.778  1.00 56.26  ? 77  VAL A N    1 
ATOM   1155 C CA   . VAL A 1 77  ? 6.416   37.226  22.708  1.00 57.93  ? 77  VAL A CA   1 
ATOM   1156 C C    . VAL A 1 77  ? 6.071   38.276  23.757  1.00 53.83  ? 77  VAL A C    1 
ATOM   1157 O O    . VAL A 1 77  ? 6.958   38.811  24.430  1.00 54.71  ? 77  VAL A O    1 
ATOM   1158 C CB   . VAL A 1 77  ? 6.970   35.948  23.355  1.00 59.75  ? 77  VAL A CB   1 
ATOM   1159 C CG1  . VAL A 1 77  ? 5.999   35.403  24.393  1.00 53.99  ? 77  VAL A CG1  1 
ATOM   1160 C CG2  . VAL A 1 77  ? 7.257   34.900  22.285  1.00 68.10  ? 77  VAL A CG2  1 
ATOM   1161 H H    . VAL A 1 77  ? 8.187   37.536  21.900  1.00 67.57  ? 77  VAL A H    1 
ATOM   1162 H HA   . VAL A 1 77  ? 5.604   36.992  22.231  1.00 69.57  ? 77  VAL A HA   1 
ATOM   1163 H HB   . VAL A 1 77  ? 7.800   36.161  23.810  1.00 71.75  ? 77  VAL A HB   1 
ATOM   1164 H HG11 . VAL A 1 77  ? 6.368   34.591  24.775  1.00 64.84  ? 77  VAL A HG11 1 
ATOM   1165 H HG12 . VAL A 1 77  ? 5.873   36.067  25.088  1.00 64.84  ? 77  VAL A HG12 1 
ATOM   1166 H HG13 . VAL A 1 77  ? 5.152   35.210  23.962  1.00 64.84  ? 77  VAL A HG13 1 
ATOM   1167 H HG21 . VAL A 1 77  ? 7.606   34.101  22.710  1.00 81.78  ? 77  VAL A HG21 1 
ATOM   1168 H HG22 . VAL A 1 77  ? 6.432   34.692  21.818  1.00 81.78  ? 77  VAL A HG22 1 
ATOM   1169 H HG23 . VAL A 1 77  ? 7.909   35.256  21.662  1.00 81.78  ? 77  VAL A HG23 1 
ATOM   1170 N N    . ILE A 1 78  ? 4.780   38.582  23.885  1.00 55.28  ? 78  ILE A N    1 
ATOM   1171 C CA   . ILE A 1 78  ? 4.284   39.549  24.856  1.00 56.08  ? 78  ILE A CA   1 
ATOM   1172 C C    . ILE A 1 78  ? 3.424   38.882  25.919  1.00 61.77  ? 78  ILE A C    1 
ATOM   1173 O O    . ILE A 1 78  ? 2.820   39.569  26.750  1.00 53.91  ? 78  ILE A O    1 
ATOM   1174 C CB   . ILE A 1 78  ? 3.512   40.685  24.164  1.00 51.74  ? 78  ILE A CB   1 
ATOM   1175 C CG1  . ILE A 1 78  ? 2.176   40.170  23.621  1.00 62.01  ? 78  ILE A CG1  1 
ATOM   1176 C CG2  . ILE A 1 78  ? 4.353   41.285  23.045  1.00 59.80  ? 78  ILE A CG2  1 
ATOM   1177 C CD1  . ILE A 1 78  ? 1.429   41.177  22.769  1.00 63.69  ? 78  ILE A CD1  1 
ATOM   1178 H H    . ILE A 1 78  ? 4.158   38.231  23.407  1.00 66.39  ? 78  ILE A H    1 
ATOM   1179 H HA   . ILE A 1 78  ? 5.047   39.942  25.308  1.00 67.36  ? 78  ILE A HA   1 
ATOM   1180 H HB   . ILE A 1 78  ? 3.326   41.377  24.817  1.00 62.14  ? 78  ILE A HB   1 
ATOM   1181 H HG12 . ILE A 1 78  ? 2.344   39.388  23.073  1.00 74.47  ? 78  ILE A HG12 1 
ATOM   1182 H HG13 . ILE A 1 78  ? 1.606   39.936  24.369  1.00 74.47  ? 78  ILE A HG13 1 
ATOM   1183 H HG21 . ILE A 1 78  ? 3.974   42.140  22.789  1.00 71.81  ? 78  ILE A HG21 1 
ATOM   1184 H HG22 . ILE A 1 78  ? 5.261   41.408  23.365  1.00 71.81  ? 78  ILE A HG22 1 
ATOM   1185 H HG23 . ILE A 1 78  ? 4.349   40.680  22.287  1.00 71.81  ? 78  ILE A HG23 1 
ATOM   1186 H HD11 . ILE A 1 78  ? 0.522   40.862  22.630  1.00 76.49  ? 78  ILE A HD11 1 
ATOM   1187 H HD12 . ILE A 1 78  ? 1.416   42.031  23.229  1.00 76.49  ? 78  ILE A HD12 1 
ATOM   1188 H HD13 . ILE A 1 78  ? 1.882   41.268  21.916  1.00 76.49  ? 78  ILE A HD13 1 
ATOM   1189 N N    . GLY A 1 79  ? 3.352   37.557  25.911  1.00 57.57  ? 79  GLY A N    1 
ATOM   1190 C CA   . GLY A 1 79  ? 2.568   36.825  26.879  1.00 52.26  ? 79  GLY A CA   1 
ATOM   1191 C C    . GLY A 1 79  ? 2.768   35.338  26.701  1.00 54.86  ? 79  GLY A C    1 
ATOM   1192 O O    . GLY A 1 79  ? 3.113   34.880  25.609  1.00 49.09  ? 79  GLY A O    1 
ATOM   1193 H H    . GLY A 1 79  ? 3.756   37.055  25.342  1.00 69.14  ? 79  GLY A H    1 
ATOM   1194 H HA2  . GLY A 1 79  ? 2.838   37.074  27.777  1.00 62.77  ? 79  GLY A HA2  1 
ATOM   1195 H HA3  . GLY A 1 79  ? 1.627   37.032  26.764  1.00 62.77  ? 79  GLY A HA3  1 
ATOM   1196 N N    . HIS A 1 80  ? 2.566   34.571  27.767  1.00 49.49  ? 80  HIS A N    1 
ATOM   1197 C CA   . HIS A 1 80  ? 2.714   33.127  27.694  1.00 49.23  ? 80  HIS A CA   1 
ATOM   1198 C C    . HIS A 1 80  ? 1.823   32.495  28.750  1.00 57.64  ? 80  HIS A C    1 
ATOM   1199 O O    . HIS A 1 80  ? 1.547   33.095  29.793  1.00 57.47  ? 80  HIS A O    1 
ATOM   1200 C CB   . HIS A 1 80  ? 4.173   32.703  27.885  1.00 48.81  ? 80  HIS A CB   1 
ATOM   1201 C CG   . HIS A 1 80  ? 4.722   33.038  29.234  1.00 53.76  ? 80  HIS A CG   1 
ATOM   1202 N ND1  . HIS A 1 80  ? 4.808   34.331  29.704  1.00 63.98  ? 80  HIS A ND1  1 
ATOM   1203 C CD2  . HIS A 1 80  ? 5.208   32.247  30.218  1.00 51.75  ? 80  HIS A CD2  1 
ATOM   1204 C CE1  . HIS A 1 80  ? 5.325   34.321  30.919  1.00 55.12  ? 80  HIS A CE1  1 
ATOM   1205 N NE2  . HIS A 1 80  ? 5.577   33.068  31.254  1.00 50.71  ? 80  HIS A NE2  1 
ATOM   1206 H H    . HIS A 1 80  ? 2.343   34.866  28.543  1.00 59.45  ? 80  HIS A H    1 
ATOM   1207 H HA   . HIS A 1 80  ? 2.424   32.805  26.826  1.00 59.13  ? 80  HIS A HA   1 
ATOM   1208 H HB2  . HIS A 1 80  ? 4.238   31.742  27.770  1.00 58.62  ? 80  HIS A HB2  1 
ATOM   1209 H HB3  . HIS A 1 80  ? 4.719   33.154  27.223  1.00 58.62  ? 80  HIS A HB3  1 
ATOM   1210 H HD1  . HIS A 1 80  ? 4.563   35.034  29.273  1.00 76.84  ? 80  HIS A HD1  1 
ATOM   1211 H HD2  . HIS A 1 80  ? 5.279   31.320  30.196  1.00 62.15  ? 80  HIS A HD2  1 
ATOM   1212 H HE1  . HIS A 1 80  ? 5.484   35.068  31.449  1.00 66.20  ? 80  HIS A HE1  1 
ATOM   1213 N N    . SER A 1 81  ? 1.364   31.283  28.459  1.00 42.49  ? 81  SER A N    1 
ATOM   1214 C CA   . SER A 1 81  ? 0.480   30.550  29.355  1.00 46.82  ? 81  SER A CA   1 
ATOM   1215 C C    . SER A 1 81  ? 0.442   29.104  28.892  1.00 44.26  ? 81  SER A C    1 
ATOM   1216 O O    . SER A 1 81  ? 0.817   28.788  27.759  1.00 49.68  ? 81  SER A O    1 
ATOM   1217 C CB   . SER A 1 81  ? -0.931  31.146  29.377  1.00 48.35  ? 81  SER A CB   1 
ATOM   1218 O OG   . SER A 1 81  ? -1.346  31.543  28.080  1.00 69.36  ? 81  SER A OG   1 
ATOM   1219 H H    . SER A 1 81  ? 1.553   30.856  27.737  1.00 51.04  ? 81  SER A H    1 
ATOM   1220 H HA   . SER A 1 81  ? 0.832   30.581  30.259  1.00 56.24  ? 81  SER A HA   1 
ATOM   1221 H HB2  . SER A 1 81  ? -1.549  30.478  29.712  1.00 58.08  ? 81  SER A HB2  1 
ATOM   1222 H HB3  . SER A 1 81  ? -0.935  31.923  29.958  1.00 58.08  ? 81  SER A HB3  1 
ATOM   1223 H HG   . SER A 1 81  ? -2.121  31.865  28.112  1.00 83.29  ? 81  SER A HG   1 
ATOM   1224 N N    . MET A 1 82  ? -0.009  28.231  29.782  1.00 43.38  ? 82  MET A N    1 
ATOM   1225 C CA   . MET A 1 82  ? -0.141  26.816  29.481  1.00 45.08  ? 82  MET A CA   1 
ATOM   1226 C C    . MET A 1 82  ? -1.618  26.457  29.418  1.00 53.26  ? 82  MET A C    1 
ATOM   1227 O O    . MET A 1 82  ? -2.395  26.851  30.294  1.00 50.61  ? 82  MET A O    1 
ATOM   1228 C CB   . MET A 1 82  ? 0.569   25.952  30.527  1.00 44.26  ? 82  MET A CB   1 
ATOM   1229 C CG   . MET A 1 82  ? 0.677   24.512  30.075  1.00 41.14  ? 82  MET A CG   1 
ATOM   1230 S SD   . MET A 1 82  ? 1.563   23.403  31.185  1.00 58.73  ? 82  MET A SD   1 
ATOM   1231 C CE   . MET A 1 82  ? 3.198   24.119  31.145  1.00 61.96  ? 82  MET A CE   1 
ATOM   1232 H H    . MET A 1 82  ? -0.248  28.440  30.581  1.00 52.11  ? 82  MET A H    1 
ATOM   1233 H HA   . MET A 1 82  ? 0.272   26.634  28.623  1.00 54.16  ? 82  MET A HA   1 
ATOM   1234 H HB2  . MET A 1 82  ? 1.464   26.295  30.671  1.00 53.17  ? 82  MET A HB2  1 
ATOM   1235 H HB3  . MET A 1 82  ? 0.067   25.975  31.356  1.00 53.17  ? 82  MET A HB3  1 
ATOM   1236 H HG2  . MET A 1 82  ? -0.220  24.157  29.971  1.00 49.43  ? 82  MET A HG2  1 
ATOM   1237 H HG3  . MET A 1 82  ? 1.141   24.495  29.223  1.00 49.43  ? 82  MET A HG3  1 
ATOM   1238 H HE1  . MET A 1 82  ? 3.730   23.733  31.859  1.00 74.41  ? 82  MET A HE1  1 
ATOM   1239 H HE2  . MET A 1 82  ? 3.607   23.926  30.287  1.00 74.41  ? 82  MET A HE2  1 
ATOM   1240 H HE3  . MET A 1 82  ? 3.126   25.078  31.269  1.00 74.41  ? 82  MET A HE3  1 
ATOM   1241 N N    . GLN A 1 83  ? -2.002  25.732  28.372  1.00 44.69  ? 83  GLN A N    1 
ATOM   1242 C CA   . GLN A 1 83  ? -3.343  25.165  28.230  1.00 49.63  ? 83  GLN A CA   1 
ATOM   1243 C C    . GLN A 1 83  ? -3.154  23.660  28.057  1.00 50.79  ? 83  GLN A C    1 
ATOM   1244 O O    . GLN A 1 83  ? -2.839  23.188  26.959  1.00 42.25  ? 83  GLN A O    1 
ATOM   1245 C CB   . GLN A 1 83  ? -4.095  25.779  27.054  1.00 49.01  ? 83  GLN A CB   1 
ATOM   1246 C CG   . GLN A 1 83  ? -5.313  24.981  26.601  1.00 55.79  ? 83  GLN A CG   1 
ATOM   1247 C CD   . GLN A 1 83  ? -6.503  25.868  26.272  1.00 66.18  ? 83  GLN A CD   1 
ATOM   1248 O OE1  . GLN A 1 83  ? -6.346  26.951  25.709  1.00 69.85  ? 83  GLN A OE1  1 
ATOM   1249 N NE2  . GLN A 1 83  ? -7.700  25.407  26.618  1.00 70.97  ? 83  GLN A NE2  1 
ATOM   1250 H H    . GLN A 1 83  ? -1.487  25.548  27.708  1.00 53.68  ? 83  GLN A H    1 
ATOM   1251 H HA   . GLN A 1 83  ? -3.866  25.340  29.028  1.00 59.62  ? 83  GLN A HA   1 
ATOM   1252 H HB2  . GLN A 1 83  ? -4.402  26.663  27.311  1.00 58.87  ? 83  GLN A HB2  1 
ATOM   1253 H HB3  . GLN A 1 83  ? -3.489  25.845  26.300  1.00 58.87  ? 83  GLN A HB3  1 
ATOM   1254 H HG2  . GLN A 1 83  ? -5.084  24.478  25.803  1.00 67.00  ? 83  GLN A HG2  1 
ATOM   1255 H HG3  . GLN A 1 83  ? -5.577  24.374  27.310  1.00 67.00  ? 83  GLN A HG3  1 
ATOM   1256 H HE21 . GLN A 1 83  ? -7.771  24.643  27.006  1.00 85.22  ? 83  GLN A HE21 1 
ATOM   1257 H HE22 . GLN A 1 83  ? -8.404  25.873  26.453  1.00 85.22  ? 83  GLN A HE22 1 
ATOM   1258 N N    . ASN A 1 84  ? -3.337  22.909  29.146  1.00 38.60  ? 84  ASN A N    1 
ATOM   1259 C CA   . ASN A 1 84  ? -3.107  21.466  29.125  1.00 38.68  ? 84  ASN A CA   1 
ATOM   1260 C C    . ASN A 1 84  ? -1.695  21.190  28.619  1.00 41.23  ? 84  ASN A C    1 
ATOM   1261 O O    . ASN A 1 84  ? -0.726  21.618  29.254  1.00 42.98  ? 84  ASN A O    1 
ATOM   1262 C CB   . ASN A 1 84  ? -4.194  20.789  28.296  1.00 43.82  ? 84  ASN A CB   1 
ATOM   1263 C CG   . ASN A 1 84  ? -5.586  21.092  28.827  1.00 46.52  ? 84  ASN A CG   1 
ATOM   1264 O OD1  . ASN A 1 84  ? -5.891  20.825  29.989  1.00 42.47  ? 84  ASN A OD1  1 
ATOM   1265 N ND2  . ASN A 1 84  ? -6.431  21.671  27.980  1.00 40.49  ? 84  ASN A ND2  1 
ATOM   1266 H H    . ASN A 1 84  ? -3.593  23.212  29.909  1.00 46.38  ? 84  ASN A H    1 
ATOM   1267 H HA   . ASN A 1 84  ? -3.166  21.078  30.012  1.00 46.47  ? 84  ASN A HA   1 
ATOM   1268 H HB2  . ASN A 1 84  ? -4.142  21.107  27.381  1.00 52.64  ? 84  ASN A HB2  1 
ATOM   1269 H HB3  . ASN A 1 84  ? -4.062  19.828  28.321  1.00 52.64  ? 84  ASN A HB3  1 
ATOM   1270 H HD21 . ASN A 1 84  ? -7.230  21.862  28.234  1.00 48.65  ? 84  ASN A HD21 1 
ATOM   1271 H HD22 . ASN A 1 84  ? -6.178  21.854  27.179  1.00 48.65  ? 84  ASN A HD22 1 
ATOM   1272 N N    . CYS A 1 85  ? -1.541  20.497  27.498  1.00 40.72  ? 85  CYS A N    1 
ATOM   1273 C CA   . CYS A 1 85  ? -0.209  20.106  27.049  1.00 30.11  ? 85  CYS A CA   1 
ATOM   1274 C C    . CYS A 1 85  ? 0.357   20.997  25.945  1.00 36.86  ? 85  CYS A C    1 
ATOM   1275 O O    . CYS A 1 85  ? 1.374   20.638  25.341  1.00 44.09  ? 85  CYS A O    1 
ATOM   1276 C CB   . CYS A 1 85  ? -0.217  18.647  26.589  1.00 35.88  ? 85  CYS A CB   1 
ATOM   1277 S SG   . CYS A 1 85  ? -0.582  17.482  27.922  1.00 36.10  ? 85  CYS A SG   1 
ATOM   1278 H H    . CYS A 1 85  ? -2.184  20.244  26.986  1.00 48.92  ? 85  CYS A H    1 
ATOM   1279 H HA   . CYS A 1 85  ? 0.391   20.184  27.807  1.00 36.18  ? 85  CYS A HA   1 
ATOM   1280 H HB2  . CYS A 1 85  ? -0.894  18.537  25.903  1.00 43.11  ? 85  CYS A HB2  1 
ATOM   1281 H HB3  . CYS A 1 85  ? 0.657   18.426  26.230  1.00 43.11  ? 85  CYS A HB3  1 
ATOM   1282 H HG   . CYS A 1 85  ? -0.540  16.364  27.487  1.00 43.37  ? 85  CYS A HG   1 
ATOM   1283 N N    . VAL A 1 86  ? -0.244  22.160  25.689  1.00 32.96  ? 86  VAL A N    1 
ATOM   1284 C CA   . VAL A 1 86  ? 0.299   23.091  24.709  1.00 38.80  ? 86  VAL A CA   1 
ATOM   1285 C C    . VAL A 1 86  ? 0.450   24.465  25.347  1.00 44.71  ? 86  VAL A C    1 
ATOM   1286 O O    . VAL A 1 86  ? -0.198  24.792  26.343  1.00 39.09  ? 86  VAL A O    1 
ATOM   1287 C CB   . VAL A 1 86  ? -0.578  23.204  23.440  1.00 40.71  ? 86  VAL A CB   1 
ATOM   1288 C CG1  . VAL A 1 86  ? -0.718  21.859  22.750  1.00 38.89  ? 86  VAL A CG1  1 
ATOM   1289 C CG2  . VAL A 1 86  ? -1.932  23.791  23.801  1.00 43.05  ? 86  VAL A CG2  1 
ATOM   1290 H H    . VAL A 1 86  ? -0.966  22.428  26.071  1.00 39.61  ? 86  VAL A H    1 
ATOM   1291 H HA   . VAL A 1 86  ? 1.179   22.774  24.450  1.00 46.62  ? 86  VAL A HA   1 
ATOM   1292 H HB   . VAL A 1 86  ? -0.149  23.800  22.807  1.00 48.91  ? 86  VAL A HB   1 
ATOM   1293 H HG11 . VAL A 1 86  ? -1.413  21.920  22.077  1.00 46.72  ? 86  VAL A HG11 1 
ATOM   1294 H HG12 . VAL A 1 86  ? 0.127   21.628  22.334  1.00 46.72  ? 86  VAL A HG12 1 
ATOM   1295 H HG13 . VAL A 1 86  ? -0.955  21.189  23.410  1.00 46.72  ? 86  VAL A HG13 1 
ATOM   1296 H HG21 . VAL A 1 86  ? -2.529  23.698  23.042  1.00 51.72  ? 86  VAL A HG21 1 
ATOM   1297 H HG22 . VAL A 1 86  ? -2.291  23.312  24.565  1.00 51.72  ? 86  VAL A HG22 1 
ATOM   1298 H HG23 . VAL A 1 86  ? -1.821  24.729  24.021  1.00 51.72  ? 86  VAL A HG23 1 
ATOM   1299 N N    . LEU A 1 87  ? 1.301   25.281  24.735  1.00 46.84  ? 87  LEU A N    1 
ATOM   1300 C CA   . LEU A 1 87  ? 1.538   26.648  25.169  1.00 44.78  ? 87  LEU A CA   1 
ATOM   1301 C C    . LEU A 1 87  ? 0.878   27.634  24.217  1.00 50.09  ? 87  LEU A C    1 
ATOM   1302 O O    . LEU A 1 87  ? 0.806   27.403  23.007  1.00 49.30  ? 87  LEU A O    1 
ATOM   1303 C CB   . LEU A 1 87  ? 3.032   26.955  25.237  1.00 42.45  ? 87  LEU A CB   1 
ATOM   1304 C CG   . LEU A 1 87  ? 3.838   26.180  26.274  1.00 46.12  ? 87  LEU A CG   1 
ATOM   1305 C CD1  . LEU A 1 87  ? 5.314   26.494  26.086  1.00 46.54  ? 87  LEU A CD1  1 
ATOM   1306 C CD2  . LEU A 1 87  ? 3.368   26.519  27.675  1.00 47.45  ? 87  LEU A CD2  1 
ATOM   1307 H H    . LEU A 1 87  ? 1.765   25.057  24.046  1.00 56.27  ? 87  LEU A H    1 
ATOM   1308 H HA   . LEU A 1 87  ? 1.153   26.764  26.052  1.00 53.79  ? 87  LEU A HA   1 
ATOM   1309 H HB2  . LEU A 1 87  ? 3.419   26.758  24.369  1.00 50.99  ? 87  LEU A HB2  1 
ATOM   1310 H HB3  . LEU A 1 87  ? 3.136   27.897  25.441  1.00 50.99  ? 87  LEU A HB3  1 
ATOM   1311 H HG   . LEU A 1 87  ? 3.710   25.225  26.159  1.00 55.40  ? 87  LEU A HG   1 
ATOM   1312 H HD11 . LEU A 1 87  ? 5.826   26.015  26.756  1.00 55.90  ? 87  LEU A HD11 1 
ATOM   1313 H HD12 . LEU A 1 87  ? 5.586   26.213  25.198  1.00 55.90  ? 87  LEU A HD12 1 
ATOM   1314 H HD13 . LEU A 1 87  ? 5.449   27.449  26.186  1.00 55.90  ? 87  LEU A HD13 1 
ATOM   1315 H HD21 . LEU A 1 87  ? 3.970   26.111  28.317  1.00 57.00  ? 87  LEU A HD21 1 
ATOM   1316 H HD22 . LEU A 1 87  ? 3.372   27.482  27.784  1.00 57.00  ? 87  LEU A HD22 1 
ATOM   1317 H HD23 . LEU A 1 87  ? 2.470   26.175  27.799  1.00 57.00  ? 87  LEU A HD23 1 
ATOM   1318 N N    . LYS A 1 88  ? 0.414   28.747  24.775  1.00 44.79  ? 88  LYS A N    1 
ATOM   1319 C CA   . LYS A 1 88  ? -0.175  29.845  24.010  1.00 44.35  ? 88  LYS A CA   1 
ATOM   1320 C C    . LYS A 1 88  ? 0.732   31.052  24.221  1.00 47.05  ? 88  LYS A C    1 
ATOM   1321 O O    . LYS A 1 88  ? 0.720   31.677  25.287  1.00 58.04  ? 88  LYS A O    1 
ATOM   1322 C CB   . LYS A 1 88  ? -1.617  30.097  24.443  1.00 50.64  ? 88  LYS A CB   1 
ATOM   1323 C CG   . LYS A 1 88  ? -2.477  28.836  24.332  1.00 50.61  ? 88  LYS A CG   1 
ATOM   1324 C CD   . LYS A 1 88  ? -3.934  29.026  24.750  1.00 44.79  ? 88  LYS A CD   1 
ATOM   1325 C CE   . LYS A 1 88  ? -4.545  30.322  24.244  1.00 51.01  ? 88  LYS A CE   1 
ATOM   1326 N NZ   . LYS A 1 88  ? -6.036  30.242  24.212  1.00 53.93  ? 88  LYS A NZ   1 
ATOM   1327 H H    . LYS A 1 88  ? 0.429   28.895  25.622  1.00 53.81  ? 88  LYS A H    1 
ATOM   1328 H HA   . LYS A 1 88  ? -0.196  29.639  23.062  1.00 53.28  ? 88  LYS A HA   1 
ATOM   1329 H HB2  . LYS A 1 88  ? -1.626  30.390  25.367  1.00 60.83  ? 88  LYS A HB2  1 
ATOM   1330 H HB3  . LYS A 1 88  ? -2.005  30.780  23.874  1.00 60.83  ? 88  LYS A HB3  1 
ATOM   1331 H HG2  . LYS A 1 88  ? -2.475  28.539  23.408  1.00 60.79  ? 88  LYS A HG2  1 
ATOM   1332 H HG3  . LYS A 1 88  ? -2.096  28.150  24.902  1.00 60.79  ? 88  LYS A HG3  1 
ATOM   1333 H HD2  . LYS A 1 88  ? -4.461  28.292  24.396  1.00 53.81  ? 88  LYS A HD2  1 
ATOM   1334 H HD3  . LYS A 1 88  ? -3.985  29.033  25.719  1.00 53.81  ? 88  LYS A HD3  1 
ATOM   1335 H HE2  . LYS A 1 88  ? -4.290  31.050  24.832  1.00 61.27  ? 88  LYS A HE2  1 
ATOM   1336 H HE3  . LYS A 1 88  ? -4.229  30.497  23.343  1.00 61.27  ? 88  LYS A HE3  1 
ATOM   1337 H HZ1  . LYS A 1 88  ? -6.376  31.011  23.919  1.00 64.77  ? 88  LYS A HZ1  1 
ATOM   1338 H HZ2  . LYS A 1 88  ? -6.294  29.586  23.668  1.00 64.77  ? 88  LYS A HZ2  1 
ATOM   1339 H HZ3  . LYS A 1 88  ? -6.350  30.080  25.029  1.00 64.77  ? 88  LYS A HZ3  1 
ATOM   1340 N N    . LEU A 1 89  ? 1.537   31.356  23.207  1.00 44.79  ? 89  LEU A N    1 
ATOM   1341 C CA   . LEU A 1 89  ? 2.500   32.452  23.251  1.00 41.39  ? 89  LEU A CA   1 
ATOM   1342 C C    . LEU A 1 89  ? 1.868   33.654  22.557  1.00 47.73  ? 89  LEU A C    1 
ATOM   1343 O O    . LEU A 1 89  ? 1.783   33.697  21.328  1.00 52.64  ? 89  LEU A O    1 
ATOM   1344 C CB   . LEU A 1 89  ? 3.807   32.046  22.579  1.00 41.09  ? 89  LEU A CB   1 
ATOM   1345 C CG   . LEU A 1 89  ? 4.501   30.813  23.155  1.00 43.07  ? 89  LEU A CG   1 
ATOM   1346 C CD1  . LEU A 1 89  ? 5.807   30.550  22.423  1.00 46.68  ? 89  LEU A CD1  1 
ATOM   1347 C CD2  . LEU A 1 89  ? 4.752   30.979  24.645  1.00 44.10  ? 89  LEU A CD2  1 
ATOM   1348 H H    . LEU A 1 89  ? 1.545   30.928  22.461  1.00 53.81  ? 89  LEU A H    1 
ATOM   1349 H HA   . LEU A 1 89  ? 2.685   32.685  24.174  1.00 49.73  ? 89  LEU A HA   1 
ATOM   1350 H HB2  . LEU A 1 89  ? 3.623   31.863  21.645  1.00 49.36  ? 89  LEU A HB2  1 
ATOM   1351 H HB3  . LEU A 1 89  ? 4.429   32.787  22.656  1.00 49.36  ? 89  LEU A HB3  1 
ATOM   1352 H HG   . LEU A 1 89  ? 3.922   30.044  23.034  1.00 51.75  ? 89  LEU A HG   1 
ATOM   1353 H HD11 . LEU A 1 89  ? 6.234   29.769  22.809  1.00 56.07  ? 89  LEU A HD11 1 
ATOM   1354 H HD12 . LEU A 1 89  ? 5.617   30.392  21.485  1.00 56.07  ? 89  LEU A HD12 1 
ATOM   1355 H HD13 . LEU A 1 89  ? 6.384   31.323  22.518  1.00 56.07  ? 89  LEU A HD13 1 
ATOM   1356 H HD21 . LEU A 1 89  ? 5.303   30.244  24.956  1.00 52.98  ? 89  LEU A HD21 1 
ATOM   1357 H HD22 . LEU A 1 89  ? 5.208   31.822  24.796  1.00 52.98  ? 89  LEU A HD22 1 
ATOM   1358 H HD23 . LEU A 1 89  ? 3.901   30.975  25.111  1.00 52.98  ? 89  LEU A HD23 1 
ATOM   1359 N N    . LYS A 1 90  ? 1.413   34.626  23.345  1.00 46.72  ? 90  LYS A N    1 
ATOM   1360 C CA   . LYS A 1 90  ? 0.924   35.872  22.771  1.00 47.75  ? 90  LYS A CA   1 
ATOM   1361 C C    . LYS A 1 90  ? 2.083   36.595  22.094  1.00 45.65  ? 90  LYS A C    1 
ATOM   1362 O O    . LYS A 1 90  ? 3.172   36.716  22.668  1.00 52.32  ? 90  LYS A O    1 
ATOM   1363 C CB   . LYS A 1 90  ? 0.299   36.761  23.841  1.00 61.14  ? 90  LYS A CB   1 
ATOM   1364 C CG   . LYS A 1 90  ? -1.209  36.588  24.015  1.00 69.05  ? 90  LYS A CG   1 
ATOM   1365 C CD   . LYS A 1 90  ? -1.995  37.335  22.945  1.00 72.44  ? 90  LYS A CD   1 
ATOM   1366 C CE   . LYS A 1 90  ? -3.453  37.521  23.349  1.00 86.17  ? 90  LYS A CE   1 
ATOM   1367 N NZ   . LYS A 1 90  ? -4.152  36.222  23.569  1.00 83.22  ? 90  LYS A NZ   1 
ATOM   1368 H H    . LYS A 1 90  ? 1.379   34.588  24.204  1.00 56.12  ? 90  LYS A H    1 
ATOM   1369 H HA   . LYS A 1 90  ? 0.233   35.681  22.117  1.00 57.36  ? 90  LYS A HA   1 
ATOM   1370 H HB2  . LYS A 1 90  ? 0.716   36.557  24.693  1.00 73.42  ? 90  LYS A HB2  1 
ATOM   1371 H HB3  . LYS A 1 90  ? 0.461   37.687  23.605  1.00 73.42  ? 90  LYS A HB3  1 
ATOM   1372 H HG2  . LYS A 1 90  ? -1.432  35.646  23.952  1.00 82.92  ? 90  LYS A HG2  1 
ATOM   1373 H HG3  . LYS A 1 90  ? -1.473  36.934  24.882  1.00 82.92  ? 90  LYS A HG3  1 
ATOM   1374 H HD2  . LYS A 1 90  ? -1.602  38.212  22.811  1.00 86.99  ? 90  LYS A HD2  1 
ATOM   1375 H HD3  . LYS A 1 90  ? -1.971  36.830  22.117  1.00 86.99  ? 90  LYS A HD3  1 
ATOM   1376 H HE2  . LYS A 1 90  ? -3.492  38.028  24.175  1.00 103.46 ? 90  LYS A HE2  1 
ATOM   1377 H HE3  . LYS A 1 90  ? -3.919  37.998  22.645  1.00 103.46 ? 90  LYS A HE3  1 
ATOM   1378 H HZ1  . LYS A 1 90  ? -4.999  36.367  23.801  1.00 99.92  ? 90  LYS A HZ1  1 
ATOM   1379 H HZ2  . LYS A 1 90  ? -4.135  35.737  22.823  1.00 99.92  ? 90  LYS A HZ2  1 
ATOM   1380 H HZ3  . LYS A 1 90  ? -3.749  35.766  24.218  1.00 99.92  ? 90  LYS A HZ3  1 
ATOM   1381 N N    . VAL A 1 91  ? 1.854   37.061  20.870  1.00 51.02  ? 91  VAL A N    1 
ATOM   1382 C CA   . VAL A 1 91  ? 2.824   37.862  20.138  1.00 52.13  ? 91  VAL A CA   1 
ATOM   1383 C C    . VAL A 1 91  ? 2.145   39.166  19.743  1.00 59.36  ? 91  VAL A C    1 
ATOM   1384 O O    . VAL A 1 91  ? 0.918   39.289  19.767  1.00 64.03  ? 91  VAL A O    1 
ATOM   1385 C CB   . VAL A 1 91  ? 3.379   37.127  18.903  1.00 64.64  ? 91  VAL A CB   1 
ATOM   1386 C CG1  . VAL A 1 91  ? 4.194   35.916  19.342  1.00 57.55  ? 91  VAL A CG1  1 
ATOM   1387 C CG2  . VAL A 1 91  ? 2.254   36.712  17.969  1.00 57.06  ? 91  VAL A CG2  1 
ATOM   1388 H H    . VAL A 1 91  ? 1.126   36.922  20.434  1.00 61.28  ? 91  VAL A H    1 
ATOM   1389 H HA   . VAL A 1 91  ? 3.577   38.069  20.713  1.00 62.62  ? 91  VAL A HA   1 
ATOM   1390 H HB   . VAL A 1 91  ? 3.961   37.728  18.412  1.00 77.62  ? 91  VAL A HB   1 
ATOM   1391 H HG11 . VAL A 1 91  ? 4.544   35.470  18.556  1.00 69.12  ? 91  VAL A HG11 1 
ATOM   1392 H HG12 . VAL A 1 91  ? 4.924   36.215  19.906  1.00 69.12  ? 91  VAL A HG12 1 
ATOM   1393 H HG13 . VAL A 1 91  ? 3.619   35.312  19.837  1.00 69.12  ? 91  VAL A HG13 1 
ATOM   1394 H HG21 . VAL A 1 91  ? 2.625   36.190  17.240  1.00 68.53  ? 91  VAL A HG21 1 
ATOM   1395 H HG22 . VAL A 1 91  ? 1.612   36.179  18.464  1.00 68.53  ? 91  VAL A HG22 1 
ATOM   1396 H HG23 . VAL A 1 91  ? 1.823   37.508  17.620  1.00 68.53  ? 91  VAL A HG23 1 
ATOM   1397 N N    . ASP A 1 92  ? 2.962   40.153  19.383  1.00 58.44  ? 92  ASP A N    1 
ATOM   1398 C CA   . ASP A 1 92  ? 2.452   41.484  19.089  1.00 68.31  ? 92  ASP A CA   1 
ATOM   1399 C C    . ASP A 1 92  ? 2.051   41.664  17.630  1.00 71.42  ? 92  ASP A C    1 
ATOM   1400 O O    . ASP A 1 92  ? 1.597   42.753  17.261  1.00 71.16  ? 92  ASP A O    1 
ATOM   1401 C CB   . ASP A 1 92  ? 3.490   42.546  19.469  1.00 78.88  ? 92  ASP A CB   1 
ATOM   1402 C CG   . ASP A 1 92  ? 4.825   42.339  18.779  1.00 81.04  ? 92  ASP A CG   1 
ATOM   1403 O OD1  . ASP A 1 92  ? 4.852   41.742  17.683  1.00 81.38  ? 92  ASP A OD1  1 
ATOM   1404 O OD2  . ASP A 1 92  ? 5.850   42.787  19.334  1.00 76.74  ? 92  ASP A OD2  1 
ATOM   1405 H H    . ASP A 1 92  ? 3.815   40.074  19.302  1.00 70.18  ? 92  ASP A H    1 
ATOM   1406 H HA   . ASP A 1 92  ? 1.661   41.631  19.631  1.00 82.03  ? 92  ASP A HA   1 
ATOM   1407 H HB2  . ASP A 1 92  ? 3.155   43.420  19.216  1.00 94.72  ? 92  ASP A HB2  1 
ATOM   1408 H HB3  . ASP A 1 92  ? 3.640   42.512  20.427  1.00 94.72  ? 92  ASP A HB3  1 
ATOM   1409 N N    . THR A 1 93  ? 2.205   40.637  16.798  1.00 75.83  ? 93  THR A N    1 
ATOM   1410 C CA   . THR A 1 93  ? 1.828   40.698  15.391  1.00 68.95  ? 93  THR A CA   1 
ATOM   1411 C C    . THR A 1 93  ? 0.785   39.628  15.109  1.00 62.97  ? 93  THR A C    1 
ATOM   1412 O O    . THR A 1 93  ? 1.044   38.436  15.310  1.00 61.16  ? 93  THR A O    1 
ATOM   1413 C CB   . THR A 1 93  ? 3.039   40.497  14.477  1.00 61.20  ? 93  THR A CB   1 
ATOM   1414 O OG1  . THR A 1 93  ? 4.175   41.184  15.016  1.00 74.83  ? 93  THR A OG1  1 
ATOM   1415 C CG2  . THR A 1 93  ? 2.745   41.021  13.079  1.00 70.75  ? 93  THR A CG2  1 
ATOM   1416 H H    . THR A 1 93  ? 2.533   39.877  17.032  1.00 91.05  ? 93  THR A H    1 
ATOM   1417 H HA   . THR A 1 93  ? 1.442   41.569  15.210  1.00 82.80  ? 93  THR A HA   1 
ATOM   1418 H HB   . THR A 1 93  ? 3.241   39.550  14.413  1.00 73.50  ? 93  THR A HB   1 
ATOM   1419 H HG1  . THR A 1 93  ? 4.843   41.067  14.521  1.00 89.86  ? 93  THR A HG1  1 
ATOM   1420 H HG21 . THR A 1 93  ? 3.518   40.893  12.507  1.00 84.96  ? 93  THR A HG21 1 
ATOM   1421 H HG22 . THR A 1 93  ? 1.990   40.546  12.698  1.00 84.96  ? 93  THR A HG22 1 
ATOM   1422 H HG23 . THR A 1 93  ? 2.536   41.968  13.116  1.00 84.96  ? 93  THR A HG23 1 
ATOM   1423 N N    . ALA A 1 94  ? -0.388  40.049  14.647  1.00 51.79  ? 94  ALA A N    1 
ATOM   1424 C CA   . ALA A 1 94  ? -1.381  39.100  14.168  1.00 57.81  ? 94  ALA A CA   1 
ATOM   1425 C C    . ALA A 1 94  ? -0.948  38.546  12.817  1.00 58.21  ? 94  ALA A C    1 
ATOM   1426 O O    . ALA A 1 94  ? -0.505  39.287  11.935  1.00 63.42  ? 94  ALA A O    1 
ATOM   1427 C CB   . ALA A 1 94  ? -2.750  39.765  14.053  1.00 50.13  ? 94  ALA A CB   1 
ATOM   1428 H H    . ALA A 1 94  ? -0.630  40.873  14.602  1.00 62.20  ? 94  ALA A H    1 
ATOM   1429 H HA   . ALA A 1 94  ? -1.464  38.365  14.797  1.00 69.43  ? 94  ALA A HA   1 
ATOM   1430 H HB1  . ALA A 1 94  ? -3.394  39.110  13.739  1.00 60.21  ? 94  ALA A HB1  1 
ATOM   1431 H HB2  . ALA A 1 94  ? -3.014  40.097  14.925  1.00 60.21  ? 94  ALA A HB2  1 
ATOM   1432 H HB3  . ALA A 1 94  ? -2.692  40.500  13.423  1.00 60.21  ? 94  ALA A HB3  1 
ATOM   1433 N N    . ASN A 1 95  ? -1.067  37.233  12.657  1.00 53.42  ? 95  ASN A N    1 
ATOM   1434 C CA   . ASN A 1 95  ? -0.690  36.586  11.407  1.00 54.14  ? 95  ASN A CA   1 
ATOM   1435 C C    . ASN A 1 95  ? -1.607  37.063  10.287  1.00 53.85  ? 95  ASN A C    1 
ATOM   1436 O O    . ASN A 1 95  ? -2.809  36.776  10.306  1.00 51.12  ? 95  ASN A O    1 
ATOM   1437 C CB   . ASN A 1 95  ? -0.770  35.067  11.553  1.00 52.69  ? 95  ASN A CB   1 
ATOM   1438 C CG   . ASN A 1 95  ? -0.252  34.334  10.334  1.00 58.10  ? 95  ASN A CG   1 
ATOM   1439 O OD1  . ASN A 1 95  ? 0.363   34.927  9.450   1.00 54.95  ? 95  ASN A OD1  1 
ATOM   1440 N ND2  . ASN A 1 95  ? -0.494  33.029  10.285  1.00 49.38  ? 95  ASN A ND2  1 
ATOM   1441 H H    . ASN A 1 95  ? -1.364  36.695  13.258  1.00 64.16  ? 95  ASN A H    1 
ATOM   1442 H HA   . ASN A 1 95  ? 0.222   36.823  11.177  1.00 65.03  ? 95  ASN A HA   1 
ATOM   1443 H HB2  . ASN A 1 95  ? -0.237  34.794  12.316  1.00 63.28  ? 95  ASN A HB2  1 
ATOM   1444 H HB3  . ASN A 1 95  ? -1.696  34.810  11.686  1.00 63.28  ? 95  ASN A HB3  1 
ATOM   1445 H HD21 . ASN A 1 95  ? -0.221  32.565  9.614   1.00 59.31  ? 95  ASN A HD21 1 
ATOM   1446 H HD22 . ASN A 1 95  ? -0.924  32.647  10.925  1.00 59.31  ? 95  ASN A HD22 1 
ATOM   1447 N N    . PRO A 1 96  ? -1.088  37.789  9.290   1.00 55.91  ? 96  PRO A N    1 
ATOM   1448 C CA   . PRO A 1 96  ? -1.969  38.230  8.195   1.00 55.96  ? 96  PRO A CA   1 
ATOM   1449 C C    . PRO A 1 96  ? -2.523  37.077  7.380   1.00 57.43  ? 96  PRO A C    1 
ATOM   1450 O O    . PRO A 1 96  ? -3.598  37.221  6.783   1.00 54.11  ? 96  PRO A O    1 
ATOM   1451 C CB   . PRO A 1 96  ? -1.066  39.139  7.351   1.00 48.50  ? 96  PRO A CB   1 
ATOM   1452 C CG   . PRO A 1 96  ? 0.310   38.631  7.604   1.00 46.71  ? 96  PRO A CG   1 
ATOM   1453 C CD   . PRO A 1 96  ? 0.326   38.129  9.030   1.00 55.94  ? 96  PRO A CD   1 
ATOM   1454 H HA   . PRO A 1 96  ? -2.703  38.761  8.544   1.00 67.20  ? 96  PRO A HA   1 
ATOM   1455 H HB2  . PRO A 1 96  ? -1.300  39.061  6.413   1.00 58.26  ? 96  PRO A HB2  1 
ATOM   1456 H HB3  . PRO A 1 96  ? -1.158  40.060  7.640   1.00 58.26  ? 96  PRO A HB3  1 
ATOM   1457 H HG2  . PRO A 1 96  ? 0.508   37.910  6.986   1.00 56.11  ? 96  PRO A HG2  1 
ATOM   1458 H HG3  . PRO A 1 96  ? 0.948   39.352  7.488   1.00 56.11  ? 96  PRO A HG3  1 
ATOM   1459 H HD2  . PRO A 1 96  ? 0.891   37.345  9.113   1.00 67.19  ? 96  PRO A HD2  1 
ATOM   1460 H HD3  . PRO A 1 96  ? 0.631   38.823  9.636   1.00 67.19  ? 96  PRO A HD3  1 
ATOM   1461 N N    . LYS A 1 97  ? -1.839  35.936  7.355   1.00 60.47  ? 97  LYS A N    1 
ATOM   1462 C CA   . LYS A 1 97  ? -2.277  34.773  6.598   1.00 60.01  ? 97  LYS A CA   1 
ATOM   1463 C C    . LYS A 1 97  ? -3.223  33.876  7.386   1.00 57.48  ? 97  LYS A C    1 
ATOM   1464 O O    . LYS A 1 97  ? -3.490  32.749  6.955   1.00 54.26  ? 97  LYS A O    1 
ATOM   1465 C CB   . LYS A 1 97  ? -1.064  33.956  6.143   1.00 57.44  ? 97  LYS A CB   1 
ATOM   1466 C CG   . LYS A 1 97  ? 0.084   34.793  5.609   1.00 59.24  ? 97  LYS A CG   1 
ATOM   1467 C CD   . LYS A 1 97  ? 0.572   34.262  4.270   1.00 59.70  ? 97  LYS A CD   1 
ATOM   1468 C CE   . LYS A 1 97  ? 1.985   34.735  3.972   1.00 65.85  ? 97  LYS A CE   1 
ATOM   1469 N NZ   . LYS A 1 97  ? 3.006   33.885  4.646   1.00 62.83  ? 97  LYS A NZ   1 
ATOM   1470 H H    . LYS A 1 97  ? -1.101  35.811  7.779   1.00 72.63  ? 97  LYS A H    1 
ATOM   1471 H HA   . LYS A 1 97  ? -2.748  35.084  5.809   1.00 72.07  ? 97  LYS A HA   1 
ATOM   1472 H HB2  . LYS A 1 97  ? -0.731  33.448  6.899   1.00 68.98  ? 97  LYS A HB2  1 
ATOM   1473 H HB3  . LYS A 1 97  ? -1.343  33.354  5.436   1.00 68.98  ? 97  LYS A HB3  1 
ATOM   1474 H HG2  . LYS A 1 97  ? -0.214  35.707  5.486   1.00 71.14  ? 97  LYS A HG2  1 
ATOM   1475 H HG3  . LYS A 1 97  ? 0.822   34.766  6.238   1.00 71.14  ? 97  LYS A HG3  1 
ATOM   1476 H HD2  . LYS A 1 97  ? 0.572   33.292  4.289   1.00 71.70  ? 97  LYS A HD2  1 
ATOM   1477 H HD3  . LYS A 1 97  ? -0.012  34.580  3.565   1.00 71.70  ? 97  LYS A HD3  1 
ATOM   1478 H HE2  . LYS A 1 97  ? 2.141   34.696  3.016   1.00 79.08  ? 97  LYS A HE2  1 
ATOM   1479 H HE3  . LYS A 1 97  ? 2.091   35.645  4.289   1.00 79.08  ? 97  LYS A HE3  1 
ATOM   1480 H HZ1  . LYS A 1 97  ? 3.822   34.187  4.462   1.00 75.45  ? 97  LYS A HZ1  1 
ATOM   1481 H HZ2  . LYS A 1 97  ? 2.882   33.902  5.527   1.00 75.45  ? 97  LYS A HZ2  1 
ATOM   1482 H HZ3  . LYS A 1 97  ? 2.938   33.045  4.360   1.00 75.45  ? 97  LYS A HZ3  1 
ATOM   1483 N N    . THR A 1 98  ? -3.729  34.338  8.519   1.00 55.72  ? 98  THR A N    1 
ATOM   1484 C CA   . THR A 1 98  ? -4.622  33.523  9.329   1.00 54.74  ? 98  THR A CA   1 
ATOM   1485 C C    . THR A 1 98  ? -5.850  33.127  8.517   1.00 46.66  ? 98  THR A C    1 
ATOM   1486 O O    . THR A 1 98  ? -6.594  34.011  8.064   1.00 48.28  ? 98  THR A O    1 
ATOM   1487 C CB   . THR A 1 98  ? -5.061  34.280  10.580  1.00 50.62  ? 98  THR A CB   1 
ATOM   1488 O OG1  . THR A 1 98  ? -3.911  34.737  11.299  1.00 51.61  ? 98  THR A OG1  1 
ATOM   1489 C CG2  . THR A 1 98  ? -5.890  33.379  11.483  1.00 57.06  ? 98  THR A CG2  1 
ATOM   1490 H H    . THR A 1 98  ? -3.571  35.120  8.842   1.00 66.92  ? 98  THR A H    1 
ATOM   1491 H HA   . THR A 1 98  ? -4.149  32.723  9.605   1.00 65.74  ? 98  THR A HA   1 
ATOM   1492 H HB   . THR A 1 98  ? -5.602  35.042  10.321  1.00 60.80  ? 98  THR A HB   1 
ATOM   1493 H HG1  . THR A 1 98  ? -3.499  35.312  10.846  1.00 61.99  ? 98  THR A HG1  1 
ATOM   1494 H HG21 . THR A 1 98  ? -6.041  33.814  12.337  1.00 68.53  ? 98  THR A HG21 1 
ATOM   1495 H HG22 . THR A 1 98  ? -6.747  33.193  11.068  1.00 68.53  ? 98  THR A HG22 1 
ATOM   1496 H HG23 . THR A 1 98  ? -5.424  32.542  11.633  1.00 68.53  ? 98  THR A HG23 1 
ATOM   1497 N N    . PRO A 1 99  ? -6.107  31.839  8.316   1.00 49.29  ? 99  PRO A N    1 
ATOM   1498 C CA   . PRO A 1 99  ? -7.321  31.420  7.614   1.00 43.27  ? 99  PRO A CA   1 
ATOM   1499 C C    . PRO A 1 99  ? -8.500  31.298  8.572   1.00 50.73  ? 99  PRO A C    1 
ATOM   1500 O O    . PRO A 1 99  ? -8.349  31.299  9.794   1.00 49.78  ? 99  PRO A O    1 
ATOM   1501 C CB   . PRO A 1 99  ? -6.930  30.047  7.056   1.00 44.93  ? 99  PRO A CB   1 
ATOM   1502 C CG   . PRO A 1 99  ? -6.036  29.484  8.142   1.00 45.84  ? 99  PRO A CG   1 
ATOM   1503 C CD   . PRO A 1 99  ? -5.296  30.678  8.743   1.00 53.76  ? 99  PRO A CD   1 
ATOM   1504 H HA   . PRO A 1 99  ? -7.542  32.027  6.890   1.00 51.98  ? 99  PRO A HA   1 
ATOM   1505 H HB2  . PRO A 1 99  ? -7.719  29.498  6.925   1.00 53.97  ? 99  PRO A HB2  1 
ATOM   1506 H HB3  . PRO A 1 99  ? -6.452  30.145  6.217   1.00 53.97  ? 99  PRO A HB3  1 
ATOM   1507 H HG2  . PRO A 1 99  ? -6.578  29.043  8.814   1.00 55.07  ? 99  PRO A HG2  1 
ATOM   1508 H HG3  . PRO A 1 99  ? -5.410  28.853  7.754   1.00 55.07  ? 99  PRO A HG3  1 
ATOM   1509 H HD2  . PRO A 1 99  ? -5.269  30.614  9.711   1.00 64.57  ? 99  PRO A HD2  1 
ATOM   1510 H HD3  . PRO A 1 99  ? -4.395  30.738  8.389   1.00 64.57  ? 99  PRO A HD3  1 
ATOM   1511 N N    . LYS A 1 100 ? -9.690  31.199  7.987   1.00 41.70  ? 100 LYS A N    1 
ATOM   1512 C CA   . LYS A 1 100 ? -10.845 30.748  8.750   1.00 55.93  ? 100 LYS A CA   1 
ATOM   1513 C C    . LYS A 1 100 ? -10.534 29.368  9.311   1.00 46.77  ? 100 LYS A C    1 
ATOM   1514 O O    . LYS A 1 100 ? -10.176 28.455  8.560   1.00 43.62  ? 100 LYS A O    1 
ATOM   1515 C CB   . LYS A 1 100 ? -12.085 30.708  7.863   1.00 41.12  ? 100 LYS A CB   1 
ATOM   1516 H H    . LYS A 1 100 ? -9.851  31.384  7.163   1.00 50.10  ? 100 LYS A H    1 
ATOM   1517 H HA   . LYS A 1 100 ? -11.036 31.362  9.477   1.00 67.18  ? 100 LYS A HA   1 
ATOM   1518 N N    . TYR A 1 101 ? -10.635 29.209  10.626  1.00 48.61  ? 101 TYR A N    1 
ATOM   1519 C CA   . TYR A 1 101 ? -10.227 27.949  11.224  1.00 47.06  ? 101 TYR A CA   1 
ATOM   1520 C C    . TYR A 1 101 ? -11.160 27.550  12.353  1.00 46.76  ? 101 TYR A C    1 
ATOM   1521 O O    . TYR A 1 101 ? -11.909 28.361  12.900  1.00 41.10  ? 101 TYR A O    1 
ATOM   1522 C CB   . TYR A 1 101 ? -8.778  28.016  11.739  1.00 44.14  ? 101 TYR A CB   1 
ATOM   1523 C CG   . TYR A 1 101 ? -8.584  28.887  12.959  1.00 50.26  ? 101 TYR A CG   1 
ATOM   1524 C CD1  . TYR A 1 101 ? -8.372  30.253  12.833  1.00 48.57  ? 101 TYR A CD1  1 
ATOM   1525 C CD2  . TYR A 1 101 ? -8.601  28.341  14.234  1.00 48.59  ? 101 TYR A CD2  1 
ATOM   1526 C CE1  . TYR A 1 101 ? -8.190  31.052  13.947  1.00 57.38  ? 101 TYR A CE1  1 
ATOM   1527 C CE2  . TYR A 1 101 ? -8.421  29.130  15.352  1.00 45.56  ? 101 TYR A CE2  1 
ATOM   1528 C CZ   . TYR A 1 101 ? -8.214  30.484  15.204  1.00 56.46  ? 101 TYR A CZ   1 
ATOM   1529 O OH   . TYR A 1 101 ? -8.033  31.268  16.321  1.00 54.17  ? 101 TYR A OH   1 
ATOM   1530 H H    . TYR A 1 101 ? -10.929 29.801  11.176  1.00 58.39  ? 101 TYR A H    1 
ATOM   1531 H HA   . TYR A 1 101 ? -10.294 27.258  10.546  1.00 56.53  ? 101 TYR A HA   1 
ATOM   1532 H HB2  . TYR A 1 101 ? -8.491  27.119  11.971  1.00 53.02  ? 101 TYR A HB2  1 
ATOM   1533 H HB3  . TYR A 1 101 ? -8.215  28.372  11.033  1.00 53.02  ? 101 TYR A HB3  1 
ATOM   1534 H HD1  . TYR A 1 101 ? -8.352  30.637  11.986  1.00 58.34  ? 101 TYR A HD1  1 
ATOM   1535 H HD2  . TYR A 1 101 ? -8.737  27.427  14.338  1.00 58.36  ? 101 TYR A HD2  1 
ATOM   1536 H HE1  . TYR A 1 101 ? -8.051  31.967  13.849  1.00 68.91  ? 101 TYR A HE1  1 
ATOM   1537 H HE2  . TYR A 1 101 ? -8.438  28.750  16.201  1.00 54.73  ? 101 TYR A HE2  1 
ATOM   1538 H HH   . TYR A 1 101 ? -8.098  30.799  17.015  1.00 65.07  ? 101 TYR A HH   1 
ATOM   1539 N N    . LYS A 1 102 ? -11.104 26.261  12.668  1.00 44.42  ? 102 LYS A N    1 
ATOM   1540 C CA   . LYS A 1 102 ? -11.819 25.656  13.775  1.00 39.44  ? 102 LYS A CA   1 
ATOM   1541 C C    . LYS A 1 102 ? -10.859 24.738  14.517  1.00 45.56  ? 102 LYS A C    1 
ATOM   1542 O O    . LYS A 1 102 ? -9.927  24.184  13.927  1.00 41.31  ? 102 LYS A O    1 
ATOM   1543 C CB   . LYS A 1 102 ? -13.027 24.842  13.300  1.00 42.35  ? 102 LYS A CB   1 
ATOM   1544 C CG   . LYS A 1 102 ? -14.300 25.642  13.087  1.00 57.28  ? 102 LYS A CG   1 
ATOM   1545 C CD   . LYS A 1 102 ? -15.496 24.717  12.851  1.00 53.42  ? 102 LYS A CD   1 
ATOM   1546 C CE   . LYS A 1 102 ? -16.086 24.892  11.454  1.00 61.00  ? 102 LYS A CE   1 
ATOM   1547 N NZ   . LYS A 1 102 ? -17.580 24.903  11.446  1.00 82.57  ? 102 LYS A NZ   1 
ATOM   1548 H H    . LYS A 1 102 ? -10.632 25.690  12.230  1.00 53.36  ? 102 LYS A H    1 
ATOM   1549 H HA   . LYS A 1 102 ? -12.143 26.347  14.374  1.00 47.39  ? 102 LYS A HA   1 
ATOM   1550 H HB2  . LYS A 1 102 ? -12.802 24.424  12.455  1.00 50.88  ? 102 LYS A HB2  1 
ATOM   1551 H HB3  . LYS A 1 102 ? -13.219 24.163  13.966  1.00 50.88  ? 102 LYS A HB3  1 
ATOM   1552 H HG2  . LYS A 1 102 ? -14.479 26.181  13.874  1.00 68.79  ? 102 LYS A HG2  1 
ATOM   1553 H HG3  . LYS A 1 102 ? -14.197 26.214  12.311  1.00 68.79  ? 102 LYS A HG3  1 
ATOM   1554 H HD2  . LYS A 1 102 ? -15.210 23.795  12.946  1.00 64.16  ? 102 LYS A HD2  1 
ATOM   1555 H HD3  . LYS A 1 102 ? -16.188 24.918  13.500  1.00 64.16  ? 102 LYS A HD3  1 
ATOM   1556 H HE2  . LYS A 1 102 ? -15.779 25.735  11.086  1.00 73.25  ? 102 LYS A HE2  1 
ATOM   1557 H HE3  . LYS A 1 102 ? -15.790 24.158  10.893  1.00 73.25  ? 102 LYS A HE3  1 
ATOM   1558 H HZ1  . LYS A 1 102 ? -17.880 24.997  10.613  1.00 99.14  ? 102 LYS A HZ1  1 
ATOM   1559 H HZ2  . LYS A 1 102 ? -17.892 24.139  11.781  1.00 99.14  ? 102 LYS A HZ2  1 
ATOM   1560 H HZ3  . LYS A 1 102 ? -17.882 25.579  11.940  1.00 99.14  ? 102 LYS A HZ3  1 
ATOM   1561 N N    . PHE A 1 103 ? -11.090 24.590  15.817  1.00 45.97  ? 103 PHE A N    1 
ATOM   1562 C CA   . PHE A 1 103 ? -10.403 23.606  16.645  1.00 37.08  ? 103 PHE A CA   1 
ATOM   1563 C C    . PHE A 1 103 ? -11.407 22.496  16.933  1.00 40.07  ? 103 PHE A C    1 
ATOM   1564 O O    . PHE A 1 103 ? -12.354 22.696  17.701  1.00 39.18  ? 103 PHE A O    1 
ATOM   1565 C CB   . PHE A 1 103 ? -9.890  24.223  17.941  1.00 44.34  ? 103 PHE A CB   1 
ATOM   1566 C CG   . PHE A 1 103 ? -8.643  25.053  17.779  1.00 41.92  ? 103 PHE A CG   1 
ATOM   1567 C CD1  . PHE A 1 103 ? -8.015  25.187  16.551  1.00 44.62  ? 103 PHE A CD1  1 
ATOM   1568 C CD2  . PHE A 1 103 ? -8.101  25.702  18.875  1.00 42.59  ? 103 PHE A CD2  1 
ATOM   1569 C CE1  . PHE A 1 103 ? -6.870  25.951  16.423  1.00 44.72  ? 103 PHE A CE1  1 
ATOM   1570 C CE2  . PHE A 1 103 ? -6.960  26.468  18.754  1.00 41.36  ? 103 PHE A CE2  1 
ATOM   1571 C CZ   . PHE A 1 103 ? -6.343  26.592  17.526  1.00 48.85  ? 103 PHE A CZ   1 
ATOM   1572 H H    . PHE A 1 103 ? -11.659 25.063  16.256  1.00 55.22  ? 103 PHE A H    1 
ATOM   1573 H HA   . PHE A 1 103 ? -9.638  23.248  16.168  1.00 44.55  ? 103 PHE A HA   1 
ATOM   1574 H HB2  . PHE A 1 103 ? -10.581 24.799  18.305  1.00 53.26  ? 103 PHE A HB2  1 
ATOM   1575 H HB3  . PHE A 1 103 ? -9.689  23.510  18.566  1.00 53.26  ? 103 PHE A HB3  1 
ATOM   1576 H HD1  . PHE A 1 103 ? -8.367  24.757  15.804  1.00 53.60  ? 103 PHE A HD1  1 
ATOM   1577 H HD2  . PHE A 1 103 ? -8.513  25.621  19.705  1.00 51.17  ? 103 PHE A HD2  1 
ATOM   1578 H HE1  . PHE A 1 103 ? -6.455  26.034  15.595  1.00 53.73  ? 103 PHE A HE1  1 
ATOM   1579 H HE2  . PHE A 1 103 ? -6.607  26.899  19.498  1.00 49.69  ? 103 PHE A HE2  1 
ATOM   1580 H HZ   . PHE A 1 103 ? -5.573  27.108  17.442  1.00 58.68  ? 103 PHE A HZ   1 
ATOM   1581 N N    . VAL A 1 104 ? -11.213 21.339  16.309  1.00 38.40  ? 104 VAL A N    1 
ATOM   1582 C CA   . VAL A 1 104 ? -12.118 20.210  16.466  1.00 39.57  ? 104 VAL A CA   1 
ATOM   1583 C C    . VAL A 1 104 ? -11.310 19.017  16.949  1.00 42.09  ? 104 VAL A C    1 
ATOM   1584 O O    . VAL A 1 104 ? -10.126 18.873  16.629  1.00 52.20  ? 104 VAL A O    1 
ATOM   1585 C CB   . VAL A 1 104 ? -12.857 19.859  15.157  1.00 44.66  ? 104 VAL A CB   1 
ATOM   1586 C CG1  . VAL A 1 104 ? -13.430 21.108  14.511  1.00 48.12  ? 104 VAL A CG1  1 
ATOM   1587 C CG2  . VAL A 1 104 ? -11.924 19.132  14.197  1.00 47.29  ? 104 VAL A CG2  1 
ATOM   1588 H H    . VAL A 1 104 ? -10.553 21.182  15.781  1.00 46.13  ? 104 VAL A H    1 
ATOM   1589 H HA   . VAL A 1 104 ? -12.786 20.434  17.134  1.00 47.54  ? 104 VAL A HA   1 
ATOM   1590 H HB   . VAL A 1 104 ? -13.597 19.267  15.364  1.00 53.65  ? 104 VAL A HB   1 
ATOM   1591 H HG11 . VAL A 1 104 ? -13.975 20.849  13.752  1.00 57.80  ? 104 VAL A HG11 1 
ATOM   1592 H HG12 . VAL A 1 104 ? -13.973 21.579  15.162  1.00 57.80  ? 104 VAL A HG12 1 
ATOM   1593 H HG13 . VAL A 1 104 ? -12.700 21.675  14.217  1.00 57.80  ? 104 VAL A HG13 1 
ATOM   1594 H HG21 . VAL A 1 104 ? -12.293 19.180  13.301  1.00 56.80  ? 104 VAL A HG21 1 
ATOM   1595 H HG22 . VAL A 1 104 ? -11.053 19.559  14.220  1.00 56.80  ? 104 VAL A HG22 1 
ATOM   1596 H HG23 . VAL A 1 104 ? -11.846 18.206  14.474  1.00 56.80  ? 104 VAL A HG23 1 
ATOM   1597 N N    . ARG A 1 105 ? -11.955 18.164  17.734  1.00 36.34  ? 105 ARG A N    1 
ATOM   1598 C CA   . ARG A 1 105 ? -11.383 16.893  18.147  1.00 37.65  ? 105 ARG A CA   1 
ATOM   1599 C C    . ARG A 1 105 ? -12.062 15.796  17.344  1.00 36.30  ? 105 ARG A C    1 
ATOM   1600 O O    . ARG A 1 105 ? -13.296 15.737  17.286  1.00 35.82  ? 105 ARG A O    1 
ATOM   1601 C CB   . ARG A 1 105 ? -11.561 16.661  19.644  1.00 39.77  ? 105 ARG A CB   1 
ATOM   1602 C CG   . ARG A 1 105 ? -10.881 15.406  20.140  1.00 38.61  ? 105 ARG A CG   1 
ATOM   1603 C CD   . ARG A 1 105 ? -11.010 15.280  21.645  1.00 40.60  ? 105 ARG A CD   1 
ATOM   1604 N NE   . ARG A 1 105 ? -10.345 14.082  22.138  1.00 39.43  ? 105 ARG A NE   1 
ATOM   1605 C CZ   . ARG A 1 105 ? -9.118  14.059  22.640  1.00 30.46  ? 105 ARG A CZ   1 
ATOM   1606 N NH1  . ARG A 1 105 ? -8.385  15.158  22.729  1.00 30.16  ? 105 ARG A NH1  1 
ATOM   1607 N NH2  . ARG A 1 105 ? -8.614  12.905  23.065  1.00 32.34  ? 105 ARG A NH2  1 
ATOM   1608 H H    . ARG A 1 105 ? -12.743 18.304  18.046  1.00 43.67  ? 105 ARG A H    1 
ATOM   1609 H HA   . ARG A 1 105 ? -10.429 16.875  17.968  1.00 45.23  ? 105 ARG A HA   1 
ATOM   1610 H HB2  . ARG A 1 105 ? -11.183 17.415  20.125  1.00 47.78  ? 105 ARG A HB2  1 
ATOM   1611 H HB3  . ARG A 1 105 ? -12.508 16.585  19.839  1.00 47.78  ? 105 ARG A HB3  1 
ATOM   1612 H HG2  . ARG A 1 105 ? -11.295 14.631  19.730  1.00 46.39  ? 105 ARG A HG2  1 
ATOM   1613 H HG3  . ARG A 1 105 ? -9.938  15.438  19.914  1.00 46.39  ? 105 ARG A HG3  1 
ATOM   1614 H HD2  . ARG A 1 105 ? -10.602 16.052  22.068  1.00 48.78  ? 105 ARG A HD2  1 
ATOM   1615 H HD3  . ARG A 1 105 ? -11.949 15.228  21.883  1.00 48.78  ? 105 ARG A HD3  1 
ATOM   1616 H HE   . ARG A 1 105 ? -10.777 13.340  22.101  1.00 47.38  ? 105 ARG A HE   1 
ATOM   1617 H HH11 . ARG A 1 105 ? -8.703  15.910  22.459  1.00 36.25  ? 105 ARG A HH11 1 
ATOM   1618 H HH12 . ARG A 1 105 ? -7.592  15.119  23.058  1.00 36.25  ? 105 ARG A HH12 1 
ATOM   1619 H HH21 . ARG A 1 105 ? -9.083  12.186  23.013  1.00 38.87  ? 105 ARG A HH21 1 
ATOM   1620 H HH22 . ARG A 1 105 ? -7.820  12.877  23.393  1.00 38.87  ? 105 ARG A HH22 1 
ATOM   1621 N N    . ILE A 1 106 ? -11.264 14.949  16.712  1.00 35.43  ? 106 ILE A N    1 
ATOM   1622 C CA   . ILE A 1 106 ? -11.782 13.943  15.824  1.00 37.81  ? 106 ILE A CA   1 
ATOM   1623 C C    . ILE A 1 106 ? -11.894 12.620  16.569  1.00 37.13  ? 106 ILE A C    1 
ATOM   1624 O O    . ILE A 1 106 ? -11.411 12.463  17.688  1.00 37.70  ? 106 ILE A O    1 
ATOM   1625 C CB   . ILE A 1 106 ? -10.910 13.795  14.556  1.00 42.08  ? 106 ILE A CB   1 
ATOM   1626 C CG1  . ILE A 1 106 ? -9.475  13.443  14.948  1.00 36.37  ? 106 ILE A CG1  1 
ATOM   1627 C CG2  . ILE A 1 106 ? -10.960 15.069  13.733  1.00 47.38  ? 106 ILE A CG2  1 
ATOM   1628 C CD1  . ILE A 1 106 ? -8.818  12.469  13.999  1.00 49.18  ? 106 ILE A CD1  1 
ATOM   1629 H H    . ILE A 1 106 ? -10.407 14.942  16.788  1.00 42.58  ? 106 ILE A H    1 
ATOM   1630 H HA   . ILE A 1 106 ? -12.673 14.211  15.550  1.00 45.43  ? 106 ILE A HA   1 
ATOM   1631 H HB   . ILE A 1 106 ? -11.260 13.072  14.012  1.00 50.56  ? 106 ILE A HB   1 
ATOM   1632 H HG12 . ILE A 1 106 ? -8.944  14.255  14.955  1.00 43.70  ? 106 ILE A HG12 1 
ATOM   1633 H HG13 . ILE A 1 106 ? -9.480  13.042  15.831  1.00 43.70  ? 106 ILE A HG13 1 
ATOM   1634 H HG21 . ILE A 1 106 ? -10.352 14.984  12.982  1.00 56.91  ? 106 ILE A HG21 1 
ATOM   1635 H HG22 . ILE A 1 106 ? -11.866 15.202  13.412  1.00 56.91  ? 106 ILE A HG22 1 
ATOM   1636 H HG23 . ILE A 1 106 ? -10.695 15.816  14.292  1.00 56.91  ? 106 ILE A HG23 1 
ATOM   1637 H HD11 . ILE A 1 106 ? -7.907  12.310  14.289  1.00 59.08  ? 106 ILE A HD11 1 
ATOM   1638 H HD12 . ILE A 1 106 ? -9.317  11.637  14.006  1.00 59.08  ? 106 ILE A HD12 1 
ATOM   1639 H HD13 . ILE A 1 106 ? -8.820  12.848  13.106  1.00 59.08  ? 106 ILE A HD13 1 
ATOM   1640 N N    . GLN A 1 107 ? -12.519 11.654  15.929  1.00 37.37  ? 107 GLN A N    1 
ATOM   1641 C CA   . GLN A 1 107 ? -12.799 10.338  16.450  1.00 38.67  ? 107 GLN A CA   1 
ATOM   1642 C C    . GLN A 1 107 ? -11.881 9.303   15.822  1.00 39.04  ? 107 GLN A C    1 
ATOM   1643 O O    . GLN A 1 107 ? -11.467 9.453   14.670  1.00 40.88  ? 107 GLN A O    1 
ATOM   1644 C CB   . GLN A 1 107 ? -14.250 9.952   16.147  1.00 43.93  ? 107 GLN A CB   1 
ATOM   1645 C CG   . GLN A 1 107 ? -15.260 10.625  17.033  1.00 40.97  ? 107 GLN A CG   1 
ATOM   1646 C CD   . GLN A 1 107 ? -15.211 10.086  18.437  1.00 38.14  ? 107 GLN A CD   1 
ATOM   1647 O OE1  . GLN A 1 107 ? -15.142 8.873   18.645  1.00 39.77  ? 107 GLN A OE1  1 
ATOM   1648 N NE2  . GLN A 1 107 ? -15.234 10.982  19.416  1.00 46.93  ? 107 GLN A NE2  1 
ATOM   1649 H H    . GLN A 1 107 ? -12.815 11.745  15.127  1.00 44.91  ? 107 GLN A H    1 
ATOM   1650 H HA   . GLN A 1 107 ? -12.659 10.328  17.409  1.00 46.46  ? 107 GLN A HA   1 
ATOM   1651 H HB2  . GLN A 1 107 ? -14.452 10.197  15.230  1.00 52.78  ? 107 GLN A HB2  1 
ATOM   1652 H HB3  . GLN A 1 107 ? -14.347 8.994   16.263  1.00 52.78  ? 107 GLN A HB3  1 
ATOM   1653 H HG2  . GLN A 1 107 ? -15.074 11.576  17.065  1.00 49.22  ? 107 GLN A HG2  1 
ATOM   1654 H HG3  . GLN A 1 107 ? -16.150 10.472  16.678  1.00 49.22  ? 107 GLN A HG3  1 
ATOM   1655 H HE21 . GLN A 1 107 ? -15.275 11.820  19.230  1.00 56.37  ? 107 GLN A HE21 1 
ATOM   1656 H HE22 . GLN A 1 107 ? -15.208 10.723  20.236  1.00 56.37  ? 107 GLN A HE22 1 
ATOM   1657 N N    . PRO A 1 108 ? -11.550 8.237   16.547  1.00 34.04  ? 108 PRO A N    1 
ATOM   1658 C CA   . PRO A 1 108 ? -10.879 7.105   15.904  1.00 37.30  ? 108 PRO A CA   1 
ATOM   1659 C C    . PRO A 1 108 ? -11.663 6.665   14.676  1.00 40.57  ? 108 PRO A C    1 
ATOM   1660 O O    . PRO A 1 108 ? -12.894 6.587   14.692  1.00 43.34  ? 108 PRO A O    1 
ATOM   1661 C CB   . PRO A 1 108 ? -10.858 6.025   16.991  1.00 52.27  ? 108 PRO A CB   1 
ATOM   1662 C CG   . PRO A 1 108 ? -11.752 6.520   18.091  1.00 48.14  ? 108 PRO A CG   1 
ATOM   1663 C CD   . PRO A 1 108 ? -11.776 8.011   17.985  1.00 41.25  ? 108 PRO A CD   1 
ATOM   1664 H HA   . PRO A 1 108 ? -9.965  7.322   15.663  1.00 44.81  ? 108 PRO A HA   1 
ATOM   1665 H HB2  . PRO A 1 108 ? -11.192 5.190   16.628  1.00 62.78  ? 108 PRO A HB2  1 
ATOM   1666 H HB3  . PRO A 1 108 ? -9.951  5.906   17.315  1.00 62.78  ? 108 PRO A HB3  1 
ATOM   1667 H HG2  . PRO A 1 108 ? -12.644 6.156   17.972  1.00 57.82  ? 108 PRO A HG2  1 
ATOM   1668 H HG3  . PRO A 1 108 ? -11.394 6.245   18.949  1.00 57.82  ? 108 PRO A HG3  1 
ATOM   1669 H HD2  . PRO A 1 108 ? -12.636 8.366   18.262  1.00 49.56  ? 108 PRO A HD2  1 
ATOM   1670 H HD3  . PRO A 1 108 ? -11.067 8.409   18.515  1.00 49.56  ? 108 PRO A HD3  1 
ATOM   1671 N N    . GLY A 1 109 ? -10.937 6.399   13.597  1.00 35.55  ? 109 GLY A N    1 
ATOM   1672 C CA   . GLY A 1 109 ? -11.525 6.043   12.330  1.00 43.00  ? 109 GLY A CA   1 
ATOM   1673 C C    . GLY A 1 109 ? -11.554 7.165   11.314  1.00 40.38  ? 109 GLY A C    1 
ATOM   1674 O O    . GLY A 1 109 ? -11.673 6.891   10.115  1.00 41.17  ? 109 GLY A O    1 
ATOM   1675 H H    . GLY A 1 109 ? -10.077 6.420   13.581  1.00 42.72  ? 109 GLY A H    1 
ATOM   1676 H HA2  . GLY A 1 109 ? -11.021 5.308   11.947  1.00 51.65  ? 109 GLY A HA2  1 
ATOM   1677 H HA3  . GLY A 1 109 ? -12.439 5.755   12.480  1.00 51.65  ? 109 GLY A HA3  1 
ATOM   1678 N N    . GLN A 1 110 ? -11.445 8.412   11.760  1.00 40.35  ? 110 GLN A N    1 
ATOM   1679 C CA   . GLN A 1 110 ? -11.429 9.563   10.871  1.00 34.37  ? 110 GLN A CA   1 
ATOM   1680 C C    . GLN A 1 110 ? -9.999  9.876   10.432  1.00 36.28  ? 110 GLN A C    1 
ATOM   1681 O O    . GLN A 1 110 ? -9.022  9.518   11.096  1.00 36.75  ? 110 GLN A O    1 
ATOM   1682 C CB   . GLN A 1 110 ? -12.052 10.780  11.558  1.00 30.99  ? 110 GLN A CB   1 
ATOM   1683 C CG   . GLN A 1 110 ? -13.571 10.697  11.754  1.00 50.37  ? 110 GLN A CG   1 
ATOM   1684 C CD   . GLN A 1 110 ? -14.314 10.220  10.516  1.00 63.10  ? 110 GLN A CD   1 
ATOM   1685 O OE1  . GLN A 1 110 ? -14.480 10.966  9.548   1.00 62.41  ? 110 GLN A OE1  1 
ATOM   1686 N NE2  . GLN A 1 110 ? -14.768 8.971   10.544  1.00 65.18  ? 110 GLN A NE2  1 
ATOM   1687 H H    . GLN A 1 110 ? -11.378 8.620   12.592  1.00 48.48  ? 110 GLN A H    1 
ATOM   1688 H HA   . GLN A 1 110 ? -11.952 9.368   10.077  1.00 41.30  ? 110 GLN A HA   1 
ATOM   1689 H HB2  . GLN A 1 110 ? -11.649 10.878  12.435  1.00 37.24  ? 110 GLN A HB2  1 
ATOM   1690 H HB3  . GLN A 1 110 ? -11.869 11.565  11.020  1.00 37.24  ? 110 GLN A HB3  1 
ATOM   1691 H HG2  . GLN A 1 110 ? -13.761 10.074  12.473  1.00 60.50  ? 110 GLN A HG2  1 
ATOM   1692 H HG3  . GLN A 1 110 ? -13.906 11.578  11.982  1.00 60.50  ? 110 GLN A HG3  1 
ATOM   1693 H HE21 . GLN A 1 110 ? -14.635 8.481   11.237  1.00 78.27  ? 110 GLN A HE21 1 
ATOM   1694 H HE22 . GLN A 1 110 ? -15.195 8.654   9.868   1.00 78.27  ? 110 GLN A HE22 1 
ATOM   1695 N N    . THR A 1 111 ? -9.888  10.551  9.292   1.00 35.49  ? 111 THR A N    1 
ATOM   1696 C CA   . THR A 1 111 ? -8.602  10.858  8.684   1.00 33.98  ? 111 THR A CA   1 
ATOM   1697 C C    . THR A 1 111 ? -8.352  12.360  8.694   1.00 31.42  ? 111 THR A C    1 
ATOM   1698 O O    . THR A 1 111 ? -9.251  13.171  8.932   1.00 31.30  ? 111 THR A O    1 
ATOM   1699 C CB   . THR A 1 111 ? -8.530  10.338  7.243   1.00 40.86  ? 111 THR A CB   1 
ATOM   1700 O OG1  . THR A 1 111 ? -9.624  10.863  6.481   1.00 36.44  ? 111 THR A OG1  1 
ATOM   1701 C CG2  . THR A 1 111 ? -8.570  8.818   7.208   1.00 39.17  ? 111 THR A CG2  1 
ATOM   1702 H H    . THR A 1 111 ? -10.559 10.847  8.844   1.00 42.64  ? 111 THR A H    1 
ATOM   1703 H HA   . THR A 1 111 ? -7.909  10.423  9.204   1.00 40.83  ? 111 THR A HA   1 
ATOM   1704 H HB   . THR A 1 111 ? -7.694  10.625  6.844   1.00 49.09  ? 111 THR A HB   1 
ATOM   1705 H HG1  . THR A 1 111 ? -9.600  10.561  5.698   1.00 43.79  ? 111 THR A HG1  1 
ATOM   1706 H HG21 . THR A 1 111 ? -8.557  8.507   6.289   1.00 47.06  ? 111 THR A HG21 1 
ATOM   1707 H HG22 . THR A 1 111 ? -7.801  8.455   7.674   1.00 47.06  ? 111 THR A HG22 1 
ATOM   1708 H HG23 . THR A 1 111 ? -9.378  8.497   7.638   1.00 47.06  ? 111 THR A HG23 1 
ATOM   1709 N N    . PHE A 1 112 ? -7.105  12.721  8.410   1.00 28.53  ? 112 PHE A N    1 
ATOM   1710 C CA   . PHE A 1 112 ? -6.707  14.116  8.317   1.00 33.88  ? 112 PHE A CA   1 
ATOM   1711 C C    . PHE A 1 112 ? -5.390  14.176  7.561   1.00 36.10  ? 112 PHE A C    1 
ATOM   1712 O O    . PHE A 1 112 ? -4.685  13.172  7.422   1.00 37.24  ? 112 PHE A O    1 
ATOM   1713 C CB   . PHE A 1 112 ? -6.576  14.760  9.698   1.00 41.52  ? 112 PHE A CB   1 
ATOM   1714 C CG   . PHE A 1 112 ? -5.662  14.016  10.628  1.00 38.67  ? 112 PHE A CG   1 
ATOM   1715 C CD1  . PHE A 1 112 ? -6.121  12.929  11.357  1.00 38.95  ? 112 PHE A CD1  1 
ATOM   1716 C CD2  . PHE A 1 112 ? -4.341  14.396  10.768  1.00 34.47  ? 112 PHE A CD2  1 
ATOM   1717 C CE1  . PHE A 1 112 ? -5.278  12.242  12.210  1.00 41.43  ? 112 PHE A CE1  1 
ATOM   1718 C CE2  . PHE A 1 112 ? -3.493  13.711  11.619  1.00 37.67  ? 112 PHE A CE2  1 
ATOM   1719 C CZ   . PHE A 1 112 ? -3.963  12.634  12.340  1.00 40.71  ? 112 PHE A CZ   1 
ATOM   1720 H H    . PHE A 1 112 ? -6.463  12.167  8.265   1.00 34.30  ? 112 PHE A H    1 
ATOM   1721 H HA   . PHE A 1 112 ? -7.373  14.617  7.821   1.00 40.72  ? 112 PHE A HA   1 
ATOM   1722 H HB2  . PHE A 1 112 ? -6.223  15.657  9.592   1.00 49.88  ? 112 PHE A HB2  1 
ATOM   1723 H HB3  . PHE A 1 112 ? -7.453  14.795  10.111  1.00 49.88  ? 112 PHE A HB3  1 
ATOM   1724 H HD1  . PHE A 1 112 ? -7.007  12.659  11.270  1.00 46.79  ? 112 PHE A HD1  1 
ATOM   1725 H HD2  . PHE A 1 112 ? -4.018  15.121  10.284  1.00 41.42  ? 112 PHE A HD2  1 
ATOM   1726 H HE1  . PHE A 1 112 ? -5.598  11.517  12.696  1.00 49.78  ? 112 PHE A HE1  1 
ATOM   1727 H HE2  . PHE A 1 112 ? -2.606  13.977  11.706  1.00 45.27  ? 112 PHE A HE2  1 
ATOM   1728 H HZ   . PHE A 1 112 ? -3.394  12.172  12.913  1.00 48.91  ? 112 PHE A HZ   1 
ATOM   1729 N N    . SER A 1 113 ? -5.078  15.364  7.059   1.00 31.42  ? 113 SER A N    1 
ATOM   1730 C CA   . SER A 1 113 ? -3.798  15.606  6.414   1.00 27.21  ? 113 SER A CA   1 
ATOM   1731 C C    . SER A 1 113 ? -2.818  16.155  7.438   1.00 33.10  ? 113 SER A C    1 
ATOM   1732 O O    . SER A 1 113 ? -3.192  16.940  8.313   1.00 34.36  ? 113 SER A O    1 
ATOM   1733 C CB   . SER A 1 113 ? -3.944  16.585  5.254   1.00 37.10  ? 113 SER A CB   1 
ATOM   1734 O OG   . SER A 1 113 ? -4.927  16.139  4.339   1.00 35.16  ? 113 SER A OG   1 
ATOM   1735 H H    . SER A 1 113 ? -5.596  16.050  7.080   1.00 37.76  ? 113 SER A H    1 
ATOM   1736 H HA   . SER A 1 113 ? -3.450  14.776  6.053   1.00 32.71  ? 113 SER A HA   1 
ATOM   1737 H HB2  . SER A 1 113 ? -4.208  17.451  5.603   1.00 44.57  ? 113 SER A HB2  1 
ATOM   1738 H HB3  . SER A 1 113 ? -3.094  16.658  4.793   1.00 44.57  ? 113 SER A HB3  1 
ATOM   1739 H HG   . SER A 1 113 ? -4.743  15.363  4.076   1.00 42.25  ? 113 SER A HG   1 
ATOM   1740 N N    . VAL A 1 114 ? -1.561  15.738  7.319   1.00 34.07  ? 114 VAL A N    1 
ATOM   1741 C CA   . VAL A 1 114 ? -0.483  16.174  8.198   1.00 30.63  ? 114 VAL A CA   1 
ATOM   1742 C C    . VAL A 1 114 ? 0.500   16.985  7.369   1.00 33.01  ? 114 VAL A C    1 
ATOM   1743 O O    . VAL A 1 114 ? 0.945   16.532  6.307   1.00 38.03  ? 114 VAL A O    1 
ATOM   1744 C CB   . VAL A 1 114 ? 0.213   14.973  8.862   1.00 38.31  ? 114 VAL A CB   1 
ATOM   1745 C CG1  . VAL A 1 114 ? 1.457   15.417  9.612   1.00 39.17  ? 114 VAL A CG1  1 
ATOM   1746 C CG2  . VAL A 1 114 ? -0.754  14.250  9.788   1.00 36.59  ? 114 VAL A CG2  1 
ATOM   1747 H H    . VAL A 1 114 ? -1.300  15.184  6.716   1.00 40.95  ? 114 VAL A H    1 
ATOM   1748 H HA   . VAL A 1 114 ? -0.841  16.744  8.896   1.00 36.81  ? 114 VAL A HA   1 
ATOM   1749 H HB   . VAL A 1 114 ? 0.494   14.351  8.173   1.00 46.02  ? 114 VAL A HB   1 
ATOM   1750 H HG11 . VAL A 1 114 ? 1.766   14.687  10.171  1.00 47.06  ? 114 VAL A HG11 1 
ATOM   1751 H HG12 . VAL A 1 114 ? 2.144   15.656  8.970   1.00 47.06  ? 114 VAL A HG12 1 
ATOM   1752 H HG13 . VAL A 1 114 ? 1.237   16.185  10.162  1.00 47.06  ? 114 VAL A HG13 1 
ATOM   1753 H HG21 . VAL A 1 114 ? -0.295  13.503  10.204  1.00 43.97  ? 114 VAL A HG21 1 
ATOM   1754 H HG22 . VAL A 1 114 ? -1.062  14.869  10.469  1.00 43.97  ? 114 VAL A HG22 1 
ATOM   1755 H HG23 . VAL A 1 114 ? -1.507  13.927  9.269   1.00 43.97  ? 114 VAL A HG23 1 
ATOM   1756 N N    . LEU A 1 115 ? 0.827   18.187  7.844   1.00 35.69  ? 115 LEU A N    1 
ATOM   1757 C CA   . LEU A 1 115 ? 1.888   19.004  7.257   1.00 33.40  ? 115 LEU A CA   1 
ATOM   1758 C C    . LEU A 1 115 ? 3.102   18.857  8.167   1.00 42.18  ? 115 LEU A C    1 
ATOM   1759 O O    . LEU A 1 115 ? 3.212   19.538  9.190   1.00 43.14  ? 115 LEU A O    1 
ATOM   1760 C CB   . LEU A 1 115 ? 1.465   20.461  7.111   1.00 33.94  ? 115 LEU A CB   1 
ATOM   1761 C CG   . LEU A 1 115 ? 2.514   21.374  6.469   1.00 41.48  ? 115 LEU A CG   1 
ATOM   1762 C CD1  . LEU A 1 115 ? 2.684   21.050  4.988   1.00 40.68  ? 115 LEU A CD1  1 
ATOM   1763 C CD2  . LEU A 1 115 ? 2.151   22.840  6.657   1.00 39.43  ? 115 LEU A CD2  1 
ATOM   1764 H H    . LEU A 1 115 ? 0.442   18.557  8.518   1.00 42.89  ? 115 LEU A H    1 
ATOM   1765 H HA   . LEU A 1 115 ? 2.100   18.677  6.369   1.00 40.13  ? 115 LEU A HA   1 
ATOM   1766 H HB2  . LEU A 1 115 ? 0.669   20.496  6.558   1.00 40.78  ? 115 LEU A HB2  1 
ATOM   1767 H HB3  . LEU A 1 115 ? 1.271   20.814  7.994   1.00 40.78  ? 115 LEU A HB3  1 
ATOM   1768 H HG   . LEU A 1 115 ? 3.364   21.220  6.910   1.00 49.83  ? 115 LEU A HG   1 
ATOM   1769 H HD11 . LEU A 1 115 ? 3.153   21.781  4.556   1.00 48.87  ? 115 LEU A HD11 1 
ATOM   1770 H HD12 . LEU A 1 115 ? 3.195   20.230  4.901   1.00 48.87  ? 115 LEU A HD12 1 
ATOM   1771 H HD13 . LEU A 1 115 ? 1.808   20.937  4.587   1.00 48.87  ? 115 LEU A HD13 1 
ATOM   1772 H HD21 . LEU A 1 115 ? 2.842   23.390  6.255   1.00 47.37  ? 115 LEU A HD21 1 
ATOM   1773 H HD22 . LEU A 1 115 ? 1.299   23.013  6.226   1.00 47.37  ? 115 LEU A HD22 1 
ATOM   1774 H HD23 . LEU A 1 115 ? 2.086   23.031  7.606   1.00 47.37  ? 115 LEU A HD23 1 
ATOM   1775 N N    . ALA A 1 116 ? 4.002   17.945  7.806   1.00 33.43  ? 116 ALA A N    1 
ATOM   1776 C CA   . ALA A 1 116 ? 5.211   17.736  8.589   1.00 32.06  ? 116 ALA A CA   1 
ATOM   1777 C C    . ALA A 1 116 ? 6.149   18.921  8.406   1.00 39.16  ? 116 ALA A C    1 
ATOM   1778 O O    . ALA A 1 116 ? 6.414   19.347  7.277   1.00 41.02  ? 116 ALA A O    1 
ATOM   1779 C CB   . ALA A 1 116 ? 5.898   16.440  8.166   1.00 42.67  ? 116 ALA A CB   1 
ATOM   1780 H H    . ALA A 1 116 ? 3.935   17.439  7.114   1.00 40.18  ? 116 ALA A H    1 
ATOM   1781 H HA   . ALA A 1 116 ? 4.985   17.660  9.529   1.00 38.53  ? 116 ALA A HA   1 
ATOM   1782 H HB1  . ALA A 1 116 ? 6.701   16.322  8.696   1.00 51.26  ? 116 ALA A HB1  1 
ATOM   1783 H HB2  . ALA A 1 116 ? 5.291   15.698  8.315   1.00 51.26  ? 116 ALA A HB2  1 
ATOM   1784 H HB3  . ALA A 1 116 ? 6.127   16.497  7.225   1.00 51.26  ? 116 ALA A HB3  1 
ATOM   1785 N N    . CYS A 1 117 ? 6.652   19.449  9.522   1.00 33.57  ? 117 CYS A N    1 
ATOM   1786 C CA   . CYS A 1 117 ? 7.478   20.642  9.519   1.00 38.99  ? 117 CYS A CA   1 
ATOM   1787 C C    . CYS A 1 117 ? 8.720   20.440  10.373  1.00 41.80  ? 117 CYS A C    1 
ATOM   1788 O O    . CYS A 1 117 ? 8.743   19.632  11.303  1.00 42.08  ? 117 CYS A O    1 
ATOM   1789 C CB   . CYS A 1 117 ? 6.724   21.864  10.058  1.00 41.04  ? 117 CYS A CB   1 
ATOM   1790 S SG   . CYS A 1 117 ? 5.280   22.343  9.116   1.00 53.58  ? 117 CYS A SG   1 
ATOM   1791 H H    . CYS A 1 117 ? 6.522   19.123  10.307  1.00 40.34  ? 117 CYS A H    1 
ATOM   1792 H HA   . CYS A 1 117 ? 7.752   20.807  8.603   1.00 46.85  ? 117 CYS A HA   1 
ATOM   1793 H HB2  . CYS A 1 117 ? 6.429   21.668  10.961  1.00 49.30  ? 117 CYS A HB2  1 
ATOM   1794 H HB3  . CYS A 1 117 ? 7.331   22.621  10.064  1.00 49.30  ? 117 CYS A HB3  1 
ATOM   1795 H HG   . CYS A 1 117 ? 4.539   21.403  9.030   1.00 64.35  ? 117 CYS A HG   1 
ATOM   1796 N N    . TYR A 1 118 ? 9.748   21.224  10.064  1.00 48.51  ? 118 TYR A N    1 
ATOM   1797 C CA   . TYR A 1 118 ? 10.983  21.246  10.833  1.00 44.66  ? 118 TYR A CA   1 
ATOM   1798 C C    . TYR A 1 118 ? 11.509  22.669  10.841  1.00 51.69  ? 118 TYR A C    1 
ATOM   1799 O O    . TYR A 1 118 ? 11.572  23.315  9.790   1.00 40.85  ? 118 TYR A O    1 
ATOM   1800 C CB   . TYR A 1 118 ? 12.013  20.280  10.242  1.00 44.92  ? 118 TYR A CB   1 
ATOM   1801 C CG   . TYR A 1 118 ? 11.557  18.843  10.309  1.00 49.35  ? 118 TYR A CG   1 
ATOM   1802 C CD1  . TYR A 1 118 ? 11.781  18.077  11.445  1.00 43.29  ? 118 TYR A CD1  1 
ATOM   1803 C CD2  . TYR A 1 118 ? 10.887  18.256  9.245   1.00 42.42  ? 118 TYR A CD2  1 
ATOM   1804 C CE1  . TYR A 1 118 ? 11.361  16.763  11.514  1.00 41.48  ? 118 TYR A CE1  1 
ATOM   1805 C CE2  . TYR A 1 118 ? 10.462  16.941  9.305   1.00 44.29  ? 118 TYR A CE2  1 
ATOM   1806 C CZ   . TYR A 1 118 ? 10.702  16.200  10.444  1.00 48.30  ? 118 TYR A CZ   1 
ATOM   1807 O OH   . TYR A 1 118 ? 10.284  14.890  10.517  1.00 45.82  ? 118 TYR A OH   1 
ATOM   1808 H H    . TYR A 1 118 ? 9.753   21.766  9.396   1.00 58.28  ? 118 TYR A H    1 
ATOM   1809 H HA   . TYR A 1 118 ? 10.821  20.976  11.750  1.00 53.65  ? 118 TYR A HA   1 
ATOM   1810 H HB2  . TYR A 1 118 ? 12.162  20.506  9.311   1.00 53.96  ? 118 TYR A HB2  1 
ATOM   1811 H HB3  . TYR A 1 118 ? 12.842  20.357  10.740  1.00 53.96  ? 118 TYR A HB3  1 
ATOM   1812 H HD1  . TYR A 1 118 ? 12.221  18.455  12.171  1.00 52.00  ? 118 TYR A HD1  1 
ATOM   1813 H HD2  . TYR A 1 118 ? 10.720  18.756  8.479   1.00 50.96  ? 118 TYR A HD2  1 
ATOM   1814 H HE1  . TYR A 1 118 ? 11.524  16.260  12.280  1.00 49.83  ? 118 TYR A HE1  1 
ATOM   1815 H HE2  . TYR A 1 118 ? 10.017  16.559  8.583   1.00 53.20  ? 118 TYR A HE2  1 
ATOM   1816 H HH   . TYR A 1 118 ? 9.970   14.647  9.777   1.00 55.04  ? 118 TYR A HH   1 
ATOM   1817 N N    . ASN A 1 119 ? 11.860  23.160  12.027  1.00 46.19  ? 119 ASN A N    1 
ATOM   1818 C CA   . ASN A 1 119 ? 12.380  24.516  12.177  1.00 46.88  ? 119 ASN A CA   1 
ATOM   1819 C C    . ASN A 1 119 ? 11.431  25.532  11.545  1.00 42.22  ? 119 ASN A C    1 
ATOM   1820 O O    . ASN A 1 119 ? 11.849  26.507  10.917  1.00 44.99  ? 119 ASN A O    1 
ATOM   1821 C CB   . ASN A 1 119 ? 13.780  24.619  11.579  1.00 55.31  ? 119 ASN A CB   1 
ATOM   1822 C CG   . ASN A 1 119 ? 14.727  23.572  12.139  1.00 56.70  ? 119 ASN A CG   1 
ATOM   1823 O OD1  . ASN A 1 119 ? 15.206  22.696  11.418  1.00 67.50  ? 119 ASN A OD1  1 
ATOM   1824 N ND2  . ASN A 1 119 ? 14.990  23.652  13.438  1.00 56.22  ? 119 ASN A ND2  1 
ATOM   1825 H H    . ASN A 1 119 ? 11.806  22.723  12.766  1.00 55.49  ? 119 ASN A H    1 
ATOM   1826 H HA   . ASN A 1 119 ? 12.441  24.729  13.121  1.00 56.31  ? 119 ASN A HA   1 
ATOM   1827 H HB2  . ASN A 1 119 ? 13.725  24.492  10.619  1.00 66.43  ? 119 ASN A HB2  1 
ATOM   1828 H HB3  . ASN A 1 119 ? 14.147  25.494  11.778  1.00 66.43  ? 119 ASN A HB3  1 
ATOM   1829 H HD21 . ASN A 1 119 ? 14.629  24.273  13.912  1.00 67.52  ? 119 ASN A HD21 1 
ATOM   1830 H HD22 . ASN A 1 119 ? 15.520  23.084  13.806  1.00 67.52  ? 119 ASN A HD22 1 
ATOM   1831 N N    . GLY A 1 120 ? 10.133  25.295  11.713  1.00 42.60  ? 120 GLY A N    1 
ATOM   1832 C CA   . GLY A 1 120 ? 9.121   26.185  11.183  1.00 43.23  ? 120 GLY A CA   1 
ATOM   1833 C C    . GLY A 1 120 ? 8.931   26.144  9.686   1.00 48.76  ? 120 GLY A C    1 
ATOM   1834 O O    . GLY A 1 120 ? 8.212   26.989  9.149   1.00 44.52  ? 120 GLY A O    1 
ATOM   1835 H H    . GLY A 1 120 ? 9.814   24.616  12.135  1.00 51.18  ? 120 GLY A H    1 
ATOM   1836 H HA2  . GLY A 1 120 ? 8.270   25.962  11.592  1.00 51.93  ? 120 GLY A HA2  1 
ATOM   1837 H HA3  . GLY A 1 120 ? 9.357   27.095  11.423  1.00 51.93  ? 120 GLY A HA3  1 
ATOM   1838 N N    . SER A 1 121 ? 9.533   25.180  8.992   1.00 46.90  ? 121 SER A N    1 
ATOM   1839 C CA   . SER A 1 121 ? 9.480   25.124  7.535   1.00 52.74  ? 121 SER A CA   1 
ATOM   1840 C C    . SER A 1 121 ? 8.800   23.845  7.068   1.00 48.92  ? 121 SER A C    1 
ATOM   1841 O O    . SER A 1 121 ? 9.260   22.744  7.417   1.00 41.50  ? 121 SER A O    1 
ATOM   1842 C CB   . SER A 1 121 ? 10.895  25.214  6.951   1.00 51.83  ? 121 SER A CB   1 
ATOM   1843 O OG   . SER A 1 121 ? 11.400  26.534  7.042   1.00 75.03  ? 121 SER A OG   1 
ATOM   1844 H H    . SER A 1 121 ? 9.983   24.539  9.348   1.00 56.34  ? 121 SER A H    1 
ATOM   1845 H HA   . SER A 1 121 ? 8.949   25.870  7.214   1.00 63.34  ? 121 SER A HA   1 
ATOM   1846 H HB2  . SER A 1 121 ? 11.479  24.619  7.446   1.00 62.25  ? 121 SER A HB2  1 
ATOM   1847 H HB3  . SER A 1 121 ? 10.868  24.952  6.017   1.00 62.25  ? 121 SER A HB3  1 
ATOM   1848 H HG   . SER A 1 121 ? 12.172  26.571  6.712   1.00 90.10  ? 121 SER A HG   1 
ATOM   1849 N N    . PRO A 1 122 ? 7.728   23.927  6.277   1.00 48.86  ? 122 PRO A N    1 
ATOM   1850 C CA   . PRO A 1 122 ? 7.061   22.699  5.822   1.00 44.67  ? 122 PRO A CA   1 
ATOM   1851 C C    . PRO A 1 122 ? 7.989   21.835  4.982   1.00 47.43  ? 122 PRO A C    1 
ATOM   1852 O O    . PRO A 1 122 ? 8.745   22.334  4.145   1.00 47.79  ? 122 PRO A O    1 
ATOM   1853 C CB   . PRO A 1 122 ? 5.878   23.218  4.993   1.00 50.26  ? 122 PRO A CB   1 
ATOM   1854 C CG   . PRO A 1 122 ? 5.654   24.615  5.472   1.00 52.89  ? 122 PRO A CG   1 
ATOM   1855 C CD   . PRO A 1 122 ? 7.024   25.137  5.809   1.00 54.90  ? 122 PRO A CD   1 
ATOM   1856 H HA   . PRO A 1 122 ? 6.736   22.189  6.581   1.00 53.66  ? 122 PRO A HA   1 
ATOM   1857 H HB2  . PRO A 1 122 ? 6.105   23.206  4.050   1.00 60.37  ? 122 PRO A HB2  1 
ATOM   1858 H HB3  . PRO A 1 122 ? 5.096   22.667  5.152   1.00 60.37  ? 122 PRO A HB3  1 
ATOM   1859 H HG2  . PRO A 1 122 ? 5.245   25.144  4.769   1.00 63.53  ? 122 PRO A HG2  1 
ATOM   1860 H HG3  . PRO A 1 122 ? 5.083   24.608  6.257   1.00 63.53  ? 122 PRO A HG3  1 
ATOM   1861 H HD2  . PRO A 1 122 ? 7.457   25.508  5.024   1.00 65.93  ? 122 PRO A HD2  1 
ATOM   1862 H HD3  . PRO A 1 122 ? 6.979   25.805  6.510   1.00 65.93  ? 122 PRO A HD3  1 
ATOM   1863 N N    . SER A 1 123 ? 7.916   20.522  5.207   1.00 46.17  ? 123 SER A N    1 
ATOM   1864 C CA   . SER A 1 123 ? 8.699   19.563  4.443   1.00 46.11  ? 123 SER A CA   1 
ATOM   1865 C C    . SER A 1 123 ? 7.865   18.606  3.604   1.00 52.09  ? 123 SER A C    1 
ATOM   1866 O O    . SER A 1 123 ? 8.346   18.152  2.564   1.00 43.51  ? 123 SER A O    1 
ATOM   1867 C CB   . SER A 1 123 ? 9.595   18.732  5.376   1.00 46.74  ? 123 SER A CB   1 
ATOM   1868 O OG   . SER A 1 123 ? 8.875   17.642  5.933   1.00 55.75  ? 123 SER A OG   1 
ATOM   1869 H H    . SER A 1 123 ? 7.412   20.163  5.804   1.00 55.46  ? 123 SER A H    1 
ATOM   1870 H HA   . SER A 1 123 ? 9.273   20.060  3.839   1.00 55.39  ? 123 SER A HA   1 
ATOM   1871 H HB2  . SER A 1 123 ? 10.345  18.387  4.868   1.00 56.14  ? 123 SER A HB2  1 
ATOM   1872 H HB3  . SER A 1 123 ? 9.914   19.299  6.095   1.00 56.14  ? 123 SER A HB3  1 
ATOM   1873 H HG   . SER A 1 123 ? 8.228   17.927  6.387   1.00 66.96  ? 123 SER A HG   1 
ATOM   1874 N N    . GLY A 1 124 ? 6.644   18.280  4.019   1.00 44.10  ? 124 GLY A N    1 
ATOM   1875 C CA   . GLY A 1 124 ? 5.830   17.358  3.250   1.00 39.17  ? 124 GLY A CA   1 
ATOM   1876 C C    . GLY A 1 124 ? 4.426   17.242  3.793   1.00 44.70  ? 124 GLY A C    1 
ATOM   1877 O O    . GLY A 1 124 ? 4.145   17.606  4.939   1.00 38.24  ? 124 GLY A O    1 
ATOM   1878 H H    . GLY A 1 124 ? 6.272   18.577  4.735   1.00 52.98  ? 124 GLY A H    1 
ATOM   1879 H HA2  . GLY A 1 124 ? 5.778   17.664  2.331   1.00 47.06  ? 124 GLY A HA2  1 
ATOM   1880 H HA3  . GLY A 1 124 ? 6.238   16.478  3.267   1.00 47.06  ? 124 GLY A HA3  1 
ATOM   1881 N N    . VAL A 1 125 ? 3.545   16.709  2.945   1.00 40.97  ? 125 VAL A N    1 
ATOM   1882 C CA   . VAL A 1 125 ? 2.136   16.519  3.261   1.00 34.38  ? 125 VAL A CA   1 
ATOM   1883 C C    . VAL A 1 125 ? 1.777   15.060  3.024   1.00 40.53  ? 125 VAL A C    1 
ATOM   1884 O O    . VAL A 1 125 ? 2.173   14.473  2.011   1.00 43.75  ? 125 VAL A O    1 
ATOM   1885 C CB   . VAL A 1 125 ? 1.224   17.430  2.406   1.00 41.40  ? 125 VAL A CB   1 
ATOM   1886 C CG1  . VAL A 1 125 ? -0.122  17.612  3.090   1.00 42.19  ? 125 VAL A CG1  1 
ATOM   1887 C CG2  . VAL A 1 125 ? 1.891   18.769  2.143   1.00 50.54  ? 125 VAL A CG2  1 
ATOM   1888 H H    . VAL A 1 125 ? 3.751   16.441  2.154   1.00 49.22  ? 125 VAL A H    1 
ATOM   1889 H HA   . VAL A 1 125 ? 1.994   16.731  4.197   1.00 41.31  ? 125 VAL A HA   1 
ATOM   1890 H HB   . VAL A 1 125 ? 1.072   17.010  1.545   1.00 49.74  ? 125 VAL A HB   1 
ATOM   1891 H HG11 . VAL A 1 125 ? -0.683  18.180  2.539   1.00 50.68  ? 125 VAL A HG11 1 
ATOM   1892 H HG12 . VAL A 1 125 ? -0.539  16.743  3.202   1.00 50.68  ? 125 VAL A HG12 1 
ATOM   1893 H HG13 . VAL A 1 125 ? 0.018   18.025  3.957   1.00 50.68  ? 125 VAL A HG13 1 
ATOM   1894 H HG21 . VAL A 1 125 ? 1.279   19.335  1.648   1.00 60.71  ? 125 VAL A HG21 1 
ATOM   1895 H HG22 . VAL A 1 125 ? 2.112   19.183  2.992   1.00 60.71  ? 125 VAL A HG22 1 
ATOM   1896 H HG23 . VAL A 1 125 ? 2.699   18.623  1.626   1.00 60.71  ? 125 VAL A HG23 1 
ATOM   1897 N N    . TYR A 1 126 ? 1.022   14.478  3.952   1.00 39.51  ? 126 TYR A N    1 
ATOM   1898 C CA   . TYR A 1 126 ? 0.530   13.118  3.787   1.00 36.73  ? 126 TYR A CA   1 
ATOM   1899 C C    . TYR A 1 126 ? -0.751  12.956  4.593   1.00 45.52  ? 126 TYR A C    1 
ATOM   1900 O O    . TYR A 1 126 ? -1.113  13.809  5.406   1.00 39.68  ? 126 TYR A O    1 
ATOM   1901 C CB   . TYR A 1 126 ? 1.590   12.074  4.191   1.00 38.81  ? 126 TYR A CB   1 
ATOM   1902 C CG   . TYR A 1 126 ? 2.137   12.196  5.598   1.00 37.75  ? 126 TYR A CG   1 
ATOM   1903 C CD1  . TYR A 1 126 ? 1.548   11.520  6.660   1.00 45.31  ? 126 TYR A CD1  1 
ATOM   1904 C CD2  . TYR A 1 126 ? 3.260   12.969  5.865   1.00 38.24  ? 126 TYR A CD2  1 
ATOM   1905 C CE1  . TYR A 1 126 ? 2.057   11.625  7.951   1.00 46.99  ? 126 TYR A CE1  1 
ATOM   1906 C CE2  . TYR A 1 126 ? 3.772   13.079  7.150   1.00 40.89  ? 126 TYR A CE2  1 
ATOM   1907 C CZ   . TYR A 1 126 ? 3.169   12.406  8.190   1.00 42.19  ? 126 TYR A CZ   1 
ATOM   1908 O OH   . TYR A 1 126 ? 3.683   12.520  9.461   1.00 49.26  ? 126 TYR A OH   1 
ATOM   1909 H H    . TYR A 1 126 ? 0.782   14.853  4.688   1.00 47.47  ? 126 TYR A H    1 
ATOM   1910 H HA   . TYR A 1 126 ? 0.314   12.969  2.853   1.00 44.13  ? 126 TYR A HA   1 
ATOM   1911 H HB2  . TYR A 1 126 ? 1.193   11.193  4.113   1.00 46.62  ? 126 TYR A HB2  1 
ATOM   1912 H HB3  . TYR A 1 126 ? 2.342   12.155  3.583   1.00 46.62  ? 126 TYR A HB3  1 
ATOM   1913 H HD1  . TYR A 1 126 ? 0.801   10.988  6.505   1.00 54.43  ? 126 TYR A HD1  1 
ATOM   1914 H HD2  . TYR A 1 126 ? 3.678   13.421  5.168   1.00 45.94  ? 126 TYR A HD2  1 
ATOM   1915 H HE1  . TYR A 1 126 ? 1.648   11.170  8.651   1.00 56.45  ? 126 TYR A HE1  1 
ATOM   1916 H HE2  . TYR A 1 126 ? 4.522   13.605  7.310   1.00 49.13  ? 126 TYR A HE2  1 
ATOM   1917 H HH   . TYR A 1 126 ? 4.320   13.067  9.466   1.00 59.17  ? 126 TYR A HH   1 
ATOM   1918 N N    . GLN A 1 127 ? -1.438  11.847  4.346   1.00 37.53  ? 127 GLN A N    1 
ATOM   1919 C CA   . GLN A 1 127 ? -2.753  11.569  4.906   1.00 41.89  ? 127 GLN A CA   1 
ATOM   1920 C C    . GLN A 1 127 ? -2.624  10.520  6.002   1.00 43.27  ? 127 GLN A C    1 
ATOM   1921 O O    . GLN A 1 127 ? -1.904  9.529   5.842   1.00 46.54  ? 127 GLN A O    1 
ATOM   1922 C CB   . GLN A 1 127 ? -3.699  11.096  3.800   1.00 42.58  ? 127 GLN A CB   1 
ATOM   1923 C CG   . GLN A 1 127 ? -5.163  11.047  4.182   1.00 42.59  ? 127 GLN A CG   1 
ATOM   1924 C CD   . GLN A 1 127 ? -5.811  12.416  4.208   1.00 41.94  ? 127 GLN A CD   1 
ATOM   1925 O OE1  . GLN A 1 127 ? -5.143  13.440  4.058   1.00 38.96  ? 127 GLN A OE1  1 
ATOM   1926 N NE2  . GLN A 1 127 ? -7.123  12.441  4.406   1.00 44.35  ? 127 GLN A NE2  1 
ATOM   1927 H H    . GLN A 1 127 ? -1.151  11.216  3.837   1.00 45.10  ? 127 GLN A H    1 
ATOM   1928 H HA   . GLN A 1 127 ? -3.135  12.365  5.308   1.00 50.33  ? 127 GLN A HA   1 
ATOM   1929 H HB2  . GLN A 1 127 ? -3.616  11.701  3.046   1.00 51.15  ? 127 GLN A HB2  1 
ATOM   1930 H HB3  . GLN A 1 127 ? -3.438  10.200  3.537   1.00 51.15  ? 127 GLN A HB3  1 
ATOM   1931 H HG2  . GLN A 1 127 ? -5.640  10.503  3.536   1.00 51.17  ? 127 GLN A HG2  1 
ATOM   1932 H HG3  . GLN A 1 127 ? -5.246  10.660  5.067   1.00 51.17  ? 127 GLN A HG3  1 
ATOM   1933 H HE21 . GLN A 1 127 ? -7.556  11.705  4.511   1.00 53.28  ? 127 GLN A HE21 1 
ATOM   1934 H HE22 . GLN A 1 127 ? -7.541  13.192  4.430   1.00 53.28  ? 127 GLN A HE22 1 
ATOM   1935 N N    . CYS A 1 128 ? -3.311  10.758  7.121   1.00 36.99  ? 128 CYS A N    1 
ATOM   1936 C CA   . CYS A 1 128 ? -3.254  9.892   8.288   1.00 43.49  ? 128 CYS A CA   1 
ATOM   1937 C C    . CYS A 1 128 ? -4.657  9.534   8.751   1.00 44.23  ? 128 CYS A C    1 
ATOM   1938 O O    . CYS A 1 128 ? -5.616  10.276  8.527   1.00 46.57  ? 128 CYS A O    1 
ATOM   1939 C CB   . CYS A 1 128 ? -2.532  10.554  9.467   1.00 42.62  ? 128 CYS A CB   1 
ATOM   1940 S SG   . CYS A 1 128 ? -0.758  10.373  9.470   1.00 47.08  ? 128 CYS A SG   1 
ATOM   1941 H H    . CYS A 1 128 ? -3.831  11.435  7.226   1.00 44.44  ? 128 CYS A H    1 
ATOM   1942 H HA   . CYS A 1 128 ? -2.782  9.085   8.028   1.00 52.25  ? 128 CYS A HA   1 
ATOM   1943 H HB2  . CYS A 1 128 ? -2.727  11.504  9.451   1.00 51.20  ? 128 CYS A HB2  1 
ATOM   1944 H HB3  . CYS A 1 128 ? -2.865  10.160  10.289  1.00 51.20  ? 128 CYS A HB3  1 
ATOM   1945 H HG   . CYS A 1 128 ? -0.327  10.729  8.408   1.00 56.55  ? 128 CYS A HG   1 
ATOM   1946 N N    . ALA A 1 129 ? -4.757  8.400   9.439   1.00 41.81  ? 129 ALA A N    1 
ATOM   1947 C CA   . ALA A 1 129 ? -5.958  8.015   10.161  1.00 42.51  ? 129 ALA A CA   1 
ATOM   1948 C C    . ALA A 1 129 ? -5.664  8.019   11.656  1.00 37.93  ? 129 ALA A C    1 
ATOM   1949 O O    . ALA A 1 129 ? -4.552  7.685   12.081  1.00 39.28  ? 129 ALA A O    1 
ATOM   1950 C CB   . ALA A 1 129 ? -6.447  6.627   9.741   1.00 45.52  ? 129 ALA A CB   1 
ATOM   1951 H H    . ALA A 1 129 ? -4.122  7.823   9.501   1.00 50.23  ? 129 ALA A H    1 
ATOM   1952 H HA   . ALA A 1 129 ? -6.667  8.649   9.972   1.00 51.07  ? 129 ALA A HA   1 
ATOM   1953 H HB1  . ALA A 1 129 ? -7.302  6.452   10.165  1.00 54.68  ? 129 ALA A HB1  1 
ATOM   1954 H HB2  . ALA A 1 129 ? -6.547  6.606   8.776   1.00 54.68  ? 129 ALA A HB2  1 
ATOM   1955 H HB3  . ALA A 1 129 ? -5.796  5.965   10.021  1.00 54.68  ? 129 ALA A HB3  1 
ATOM   1956 N N    . MET A 1 130 ? -6.653  8.411   12.450  1.00 37.01  ? 130 MET A N    1 
ATOM   1957 C CA   . MET A 1 130 ? -6.585  8.230   13.892  1.00 40.55  ? 130 MET A CA   1 
ATOM   1958 C C    . MET A 1 130 ? -6.984  6.792   14.196  1.00 42.72  ? 130 MET A C    1 
ATOM   1959 O O    . MET A 1 130 ? -8.118  6.389   13.919  1.00 36.36  ? 130 MET A O    1 
ATOM   1960 C CB   . MET A 1 130 ? -7.493  9.234   14.597  1.00 33.90  ? 130 MET A CB   1 
ATOM   1961 C CG   . MET A 1 130 ? -7.665  8.991   16.080  1.00 46.58  ? 130 MET A CG   1 
ATOM   1962 S SD   . MET A 1 130 ? -6.201  9.462   17.036  1.00 40.00  ? 130 MET A SD   1 
ATOM   1963 C CE   . MET A 1 130 ? -6.044  11.214  16.660  1.00 33.59  ? 130 MET A CE   1 
ATOM   1964 H H    . MET A 1 130 ? -7.377  8.786   12.176  1.00 44.47  ? 130 MET A H    1 
ATOM   1965 H HA   . MET A 1 130 ? -5.686  8.394   14.218  1.00 48.71  ? 130 MET A HA   1 
ATOM   1966 H HB2  . MET A 1 130 ? -7.116  10.121  14.487  1.00 40.73  ? 130 MET A HB2  1 
ATOM   1967 H HB3  . MET A 1 130 ? -8.372  9.194   14.190  1.00 40.73  ? 130 MET A HB3  1 
ATOM   1968 H HG2  . MET A 1 130 ? -8.415  9.514   16.402  1.00 55.95  ? 130 MET A HG2  1 
ATOM   1969 H HG3  . MET A 1 130 ? -7.830  8.047   16.230  1.00 55.95  ? 130 MET A HG3  1 
ATOM   1970 H HE1  . MET A 1 130 ? -5.314  11.585  17.180  1.00 40.37  ? 130 MET A HE1  1 
ATOM   1971 H HE2  . MET A 1 130 ? -5.861  11.318  15.713  1.00 40.37  ? 130 MET A HE2  1 
ATOM   1972 H HE3  . MET A 1 130 ? -6.873  11.662  16.888  1.00 40.37  ? 130 MET A HE3  1 
ATOM   1973 N N    . ARG A 1 131 ? -6.051  6.013   14.739  1.00 33.09  ? 131 ARG A N    1 
ATOM   1974 C CA   . ARG A 1 131 ? -6.299  4.599   14.958  1.00 30.22  ? 131 ARG A CA   1 
ATOM   1975 C C    . ARG A 1 131 ? -7.274  4.404   16.114  1.00 36.70  ? 131 ARG A C    1 
ATOM   1976 O O    . ARG A 1 131 ? -7.433  5.284   16.962  1.00 41.19  ? 131 ARG A O    1 
ATOM   1977 C CB   . ARG A 1 131 ? -4.998  3.862   15.262  1.00 32.27  ? 131 ARG A CB   1 
ATOM   1978 C CG   . ARG A 1 131 ? -3.925  4.014   14.200  1.00 35.48  ? 131 ARG A CG   1 
ATOM   1979 C CD   . ARG A 1 131 ? -4.427  3.562   12.844  1.00 38.45  ? 131 ARG A CD   1 
ATOM   1980 N NE   . ARG A 1 131 ? -5.043  2.240   12.885  1.00 39.04  ? 131 ARG A NE   1 
ATOM   1981 C CZ   . ARG A 1 131 ? -5.663  1.674   11.859  1.00 49.73  ? 131 ARG A CZ   1 
ATOM   1982 N NH1  . ARG A 1 131 ? -5.778  2.295   10.697  1.00 35.29  ? 131 ARG A NH1  1 
ATOM   1983 N NH2  . ARG A 1 131 ? -6.177  0.456   12.003  1.00 41.31  ? 131 ARG A NH2  1 
ATOM   1984 H H    . ARG A 1 131 ? -5.272  6.280   14.987  1.00 39.76  ? 131 ARG A H    1 
ATOM   1985 H HA   . ARG A 1 131 ? -6.686  4.218   14.154  1.00 36.32  ? 131 ARG A HA   1 
ATOM   1986 H HB2  . ARG A 1 131 ? -4.636  4.204   16.095  1.00 38.78  ? 131 ARG A HB2  1 
ATOM   1987 H HB3  . ARG A 1 131 ? -5.192  2.916   15.349  1.00 38.78  ? 131 ARG A HB3  1 
ATOM   1988 H HG2  . ARG A 1 131 ? -3.667  4.947   14.135  1.00 42.63  ? 131 ARG A HG2  1 
ATOM   1989 H HG3  . ARG A 1 131 ? -3.157  3.473   14.439  1.00 42.63  ? 131 ARG A HG3  1 
ATOM   1990 H HD2  . ARG A 1 131 ? -5.091  4.193   12.525  1.00 46.20  ? 131 ARG A HD2  1 
ATOM   1991 H HD3  . ARG A 1 131 ? -3.680  3.526   12.226  1.00 46.20  ? 131 ARG A HD3  1 
ATOM   1992 H HE   . ARG A 1 131 ? -5.001  1.799   13.623  1.00 46.91  ? 131 ARG A HE   1 
ATOM   1993 H HH11 . ARG A 1 131 ? -5.447  3.082   10.595  1.00 42.40  ? 131 ARG A HH11 1 
ATOM   1994 H HH12 . ARG A 1 131 ? -6.184  1.911   10.043  1.00 42.40  ? 131 ARG A HH12 1 
ATOM   1995 H HH21 . ARG A 1 131 ? -6.105  0.045   12.755  1.00 49.63  ? 131 ARG A HH21 1 
ATOM   1996 H HH22 . ARG A 1 131 ? -6.581  0.080   11.344  1.00 49.63  ? 131 ARG A HH22 1 
ATOM   1997 N N    . PRO A 1 132 ? -7.944  3.253   16.165  1.00 39.30  ? 132 PRO A N    1 
ATOM   1998 C CA   . PRO A 1 132 ? -8.786  2.961   17.334  1.00 35.66  ? 132 PRO A CA   1 
ATOM   1999 C C    . PRO A 1 132 ? -8.055  3.072   18.662  1.00 37.87  ? 132 PRO A C    1 
ATOM   2000 O O    . PRO A 1 132 ? -8.702  3.321   19.686  1.00 37.73  ? 132 PRO A O    1 
ATOM   2001 C CB   . PRO A 1 132 ? -9.265  1.527   17.062  1.00 39.84  ? 132 PRO A CB   1 
ATOM   2002 C CG   . PRO A 1 132 ? -9.323  1.454   15.558  1.00 37.34  ? 132 PRO A CG   1 
ATOM   2003 C CD   . PRO A 1 132 ? -8.116  2.249   15.094  1.00 40.80  ? 132 PRO A CD   1 
ATOM   2004 H HA   . PRO A 1 132 ? -9.551  3.558   17.348  1.00 42.85  ? 132 PRO A HA   1 
ATOM   2005 H HB2  . PRO A 1 132 ? -8.631  0.887   17.422  1.00 47.87  ? 132 PRO A HB2  1 
ATOM   2006 H HB3  . PRO A 1 132 ? -10.140 1.384   17.456  1.00 47.87  ? 132 PRO A HB3  1 
ATOM   2007 H HG2  . PRO A 1 132 ? -9.266  0.530   15.267  1.00 44.86  ? 132 PRO A HG2  1 
ATOM   2008 H HG3  . PRO A 1 132 ? -10.148 1.852   15.237  1.00 44.86  ? 132 PRO A HG3  1 
ATOM   2009 H HD2  . PRO A 1 132 ? -7.333  1.681   15.024  1.00 49.02  ? 132 PRO A HD2  1 
ATOM   2010 H HD3  . PRO A 1 132 ? -8.291  2.679   14.242  1.00 49.02  ? 132 PRO A HD3  1 
ATOM   2011 N N    . ASN A 1 133 ? -6.734  2.898   18.691  1.00 36.67  ? 133 ASN A N    1 
ATOM   2012 C CA   . ASN A 1 133 ? -5.985  3.034   19.935  1.00 37.91  ? 133 ASN A CA   1 
ATOM   2013 C C    . ASN A 1 133 ? -5.414  4.435   20.126  1.00 36.73  ? 133 ASN A C    1 
ATOM   2014 O O    . ASN A 1 133 ? -4.518  4.623   20.956  1.00 40.09  ? 133 ASN A O    1 
ATOM   2015 C CB   . ASN A 1 133 ? -4.872  1.985   20.008  1.00 42.11  ? 133 ASN A CB   1 
ATOM   2016 C CG   . ASN A 1 133 ? -3.757  2.229   19.012  1.00 40.12  ? 133 ASN A CG   1 
ATOM   2017 O OD1  . ASN A 1 133 ? -3.718  3.249   18.326  1.00 33.62  ? 133 ASN A OD1  1 
ATOM   2018 N ND2  . ASN A 1 133 ? -2.833  1.280   18.933  1.00 42.05  ? 133 ASN A ND2  1 
ATOM   2019 H H    . ASN A 1 133 ? -6.253  2.701   18.006  1.00 44.06  ? 133 ASN A H    1 
ATOM   2020 H HA   . ASN A 1 133 ? -6.591  2.862   20.672  1.00 45.55  ? 133 ASN A HA   1 
ATOM   2021 H HB2  . ASN A 1 133 ? -4.485  1.999   20.898  1.00 50.59  ? 133 ASN A HB2  1 
ATOM   2022 H HB3  . ASN A 1 133 ? -5.250  1.111   19.824  1.00 50.59  ? 133 ASN A HB3  1 
ATOM   2023 H HD21 . ASN A 1 133 ? -2.176  1.364   18.384  1.00 50.52  ? 133 ASN A HD21 1 
ATOM   2024 H HD22 . ASN A 1 133 ? -2.892  0.580   19.430  1.00 50.52  ? 133 ASN A HD22 1 
ATOM   2025 N N    . PHE A 1 134 ? -5.908  5.412   19.368  1.00 34.49  ? 134 PHE A N    1 
ATOM   2026 C CA   . PHE A 1 134 ? -5.565  6.823   19.517  1.00 37.86  ? 134 PHE A CA   1 
ATOM   2027 C C    . PHE A 1 134 ? -4.117  7.137   19.162  1.00 39.77  ? 134 PHE A C    1 
ATOM   2028 O O    . PHE A 1 134 ? -3.611  8.203   19.515  1.00 47.28  ? 134 PHE A O    1 
ATOM   2029 C CB   . PHE A 1 134 ? -5.857  7.320   20.938  1.00 31.16  ? 134 PHE A CB   1 
ATOM   2030 C CG   . PHE A 1 134 ? -7.319  7.428   21.255  1.00 33.06  ? 134 PHE A CG   1 
ATOM   2031 C CD1  . PHE A 1 134 ? -8.096  8.425   20.686  1.00 38.19  ? 134 PHE A CD1  1 
ATOM   2032 C CD2  . PHE A 1 134 ? -7.920  6.532   22.122  1.00 37.58  ? 134 PHE A CD2  1 
ATOM   2033 C CE1  . PHE A 1 134 ? -9.446  8.525   20.976  1.00 39.59  ? 134 PHE A CE1  1 
ATOM   2034 C CE2  . PHE A 1 134 ? -9.271  6.628   22.415  1.00 42.83  ? 134 PHE A CE2  1 
ATOM   2035 C CZ   . PHE A 1 134 ? -10.033 7.625   21.840  1.00 38.42  ? 134 PHE A CZ   1 
ATOM   2036 H H    . PHE A 1 134 ? -6.470  5.274   18.731  1.00 41.44  ? 134 PHE A H    1 
ATOM   2037 H HA   . PHE A 1 134 ? -6.121  7.318   18.896  1.00 45.48  ? 134 PHE A HA   1 
ATOM   2038 H HB2  . PHE A 1 134 ? -5.462  6.702   21.572  1.00 37.44  ? 134 PHE A HB2  1 
ATOM   2039 H HB3  . PHE A 1 134 ? -5.466  8.201   21.047  1.00 37.44  ? 134 PHE A HB3  1 
ATOM   2040 H HD1  . PHE A 1 134 ? -7.705  9.035   20.102  1.00 45.89  ? 134 PHE A HD1  1 
ATOM   2041 H HD2  . PHE A 1 134 ? -7.411  5.858   22.513  1.00 45.16  ? 134 PHE A HD2  1 
ATOM   2042 H HE1  . PHE A 1 134 ? -9.956  9.199   20.588  1.00 47.57  ? 134 PHE A HE1  1 
ATOM   2043 H HE2  . PHE A 1 134 ? -9.665  6.020   22.999  1.00 51.45  ? 134 PHE A HE2  1 
ATOM   2044 H HZ   . PHE A 1 134 ? -10.941 7.689   22.035  1.00 46.16  ? 134 PHE A HZ   1 
ATOM   2045 N N    . THR A 1 135 ? -3.427  6.233   18.478  1.00 30.76  ? 135 THR A N    1 
ATOM   2046 C CA   . THR A 1 135 ? -2.154  6.558   17.855  1.00 33.64  ? 135 THR A CA   1 
ATOM   2047 C C    . THR A 1 135 ? -2.392  6.872   16.379  1.00 36.94  ? 135 THR A C    1 
ATOM   2048 O O    . THR A 1 135 ? -3.474  6.642   15.833  1.00 39.26  ? 135 THR A O    1 
ATOM   2049 C CB   . THR A 1 135 ? -1.145  5.413   18.000  1.00 33.81  ? 135 THR A CB   1 
ATOM   2050 O OG1  . THR A 1 135 ? -1.606  4.268   17.273  1.00 36.68  ? 135 THR A OG1  1 
ATOM   2051 C CG2  . THR A 1 135 ? -0.942  5.045   19.465  1.00 41.20  ? 135 THR A CG2  1 
ATOM   2052 H H    . THR A 1 135 ? -3.679  5.419   18.362  1.00 36.97  ? 135 THR A H    1 
ATOM   2053 H HA   . THR A 1 135 ? -1.768  7.331   18.295  1.00 40.43  ? 135 THR A HA   1 
ATOM   2054 H HB   . THR A 1 135 ? -0.288  5.696   17.644  1.00 40.63  ? 135 THR A HB   1 
ATOM   2055 H HG1  . THR A 1 135 ? -2.346  4.013   17.579  1.00 44.07  ? 135 THR A HG1  1 
ATOM   2056 H HG21 . THR A 1 135 ? -0.259  4.361   19.543  1.00 49.50  ? 135 THR A HG21 1 
ATOM   2057 H HG22 . THR A 1 135 ? -0.665  5.826   19.968  1.00 49.50  ? 135 THR A HG22 1 
ATOM   2058 H HG23 . THR A 1 135 ? -1.770  4.706   19.840  1.00 49.50  ? 135 THR A HG23 1 
ATOM   2059 N N    . ILE A 1 136 ? -1.367  7.415   15.735  1.00 35.43  ? 136 ILE A N    1 
ATOM   2060 C CA   . ILE A 1 136 ? -1.385  7.606   14.292  1.00 37.89  ? 136 ILE A CA   1 
ATOM   2061 C C    . ILE A 1 136 ? -0.087  7.039   13.738  1.00 40.90  ? 136 ILE A C    1 
ATOM   2062 O O    . ILE A 1 136 ? 0.962   7.083   14.389  1.00 37.10  ? 136 ILE A O    1 
ATOM   2063 C CB   . ILE A 1 136 ? -1.572  9.086   13.891  1.00 41.14  ? 136 ILE A CB   1 
ATOM   2064 C CG1  . ILE A 1 136 ? -0.286  9.889   14.074  1.00 44.26  ? 136 ILE A CG1  1 
ATOM   2065 C CG2  . ILE A 1 136 ? -2.702  9.716   14.705  1.00 44.05  ? 136 ILE A CG2  1 
ATOM   2066 C CD1  . ILE A 1 136 ? -0.429  11.345  13.653  1.00 53.25  ? 136 ILE A CD1  1 
ATOM   2067 H H    . ILE A 1 136 ? -0.644  7.682   16.116  1.00 42.57  ? 136 ILE A H    1 
ATOM   2068 H HA   . ILE A 1 136 ? -2.128  7.118   13.906  1.00 45.52  ? 136 ILE A HA   1 
ATOM   2069 H HB   . ILE A 1 136 ? -1.803  9.103   12.949  1.00 49.43  ? 136 ILE A HB   1 
ATOM   2070 H HG12 . ILE A 1 136 ? -0.035  9.872   15.011  1.00 53.17  ? 136 ILE A HG12 1 
ATOM   2071 H HG13 . ILE A 1 136 ? 0.415   9.489   13.535  1.00 53.17  ? 136 ILE A HG13 1 
ATOM   2072 H HG21 . ILE A 1 136 ? -2.949  10.562  14.299  1.00 52.92  ? 136 ILE A HG21 1 
ATOM   2073 H HG22 . ILE A 1 136 ? -3.463  9.115   14.707  1.00 52.92  ? 136 ILE A HG22 1 
ATOM   2074 H HG23 . ILE A 1 136 ? -2.393  9.863   15.612  1.00 52.92  ? 136 ILE A HG23 1 
ATOM   2075 H HD11 . ILE A 1 136 ? 0.444   11.765  13.667  1.00 63.96  ? 136 ILE A HD11 1 
ATOM   2076 H HD12 . ILE A 1 136 ? -0.799  11.379  12.756  1.00 63.96  ? 136 ILE A HD12 1 
ATOM   2077 H HD13 . ILE A 1 136 ? -1.024  11.796  14.272  1.00 63.96  ? 136 ILE A HD13 1 
ATOM   2078 N N    . LYS A 1 137 ? -0.168  6.476   12.538  1.00 41.22  ? 137 LYS A N    1 
ATOM   2079 C CA   . LYS A 1 137 ? 0.992   5.902   11.856  1.00 41.20  ? 137 LYS A CA   1 
ATOM   2080 C C    . LYS A 1 137 ? 1.475   6.951   10.860  1.00 41.44  ? 137 LYS A C    1 
ATOM   2081 O O    . LYS A 1 137 ? 1.083   6.958   9.691   1.00 44.47  ? 137 LYS A O    1 
ATOM   2082 C CB   . LYS A 1 137 ? 0.632   4.583   11.185  1.00 49.79  ? 137 LYS A CB   1 
ATOM   2083 C CG   . LYS A 1 137 ? -0.042  3.596   12.130  1.00 47.30  ? 137 LYS A CG   1 
ATOM   2084 C CD   . LYS A 1 137 ? -0.266  2.235   11.484  1.00 61.98  ? 137 LYS A CD   1 
ATOM   2085 C CE   . LYS A 1 137 ? -1.157  1.358   12.358  1.00 75.57  ? 137 LYS A CE   1 
ATOM   2086 N NZ   . LYS A 1 137 ? -1.369  -0.003  11.790  1.00 80.62  ? 137 LYS A NZ   1 
ATOM   2087 H H    . LYS A 1 137 ? -0.898  6.412   12.088  1.00 49.52  ? 137 LYS A H    1 
ATOM   2088 H HA   . LYS A 1 137 ? 1.702   5.723   12.492  1.00 49.50  ? 137 LYS A HA   1 
ATOM   2089 H HB2  . LYS A 1 137 ? 0.021   4.760   10.453  1.00 59.81  ? 137 LYS A HB2  1 
ATOM   2090 H HB3  . LYS A 1 137 ? 1.442   4.170   10.849  1.00 59.81  ? 137 LYS A HB3  1 
ATOM   2091 H HG2  . LYS A 1 137 ? 0.520   3.469   12.911  1.00 56.82  ? 137 LYS A HG2  1 
ATOM   2092 H HG3  . LYS A 1 137 ? -0.905  3.949   12.396  1.00 56.82  ? 137 LYS A HG3  1 
ATOM   2093 H HD2  . LYS A 1 137 ? -0.700  2.353   10.624  1.00 74.43  ? 137 LYS A HD2  1 
ATOM   2094 H HD3  . LYS A 1 137 ? 0.586   1.787   11.367  1.00 74.43  ? 137 LYS A HD3  1 
ATOM   2095 H HE2  . LYS A 1 137 ? -0.743  1.257   13.230  1.00 90.75  ? 137 LYS A HE2  1 
ATOM   2096 H HE3  . LYS A 1 137 ? -2.025  1.782   12.451  1.00 90.75  ? 137 LYS A HE3  1 
ATOM   2097 H HZ1  . LYS A 1 137 ? -1.899  -0.477  12.324  1.00 96.80  ? 137 LYS A HZ1  1 
ATOM   2098 H HZ2  . LYS A 1 137 ? -1.749  0.058   10.987  1.00 96.80  ? 137 LYS A HZ2  1 
ATOM   2099 H HZ3  . LYS A 1 137 ? -0.589  -0.424  11.709  1.00 96.80  ? 137 LYS A HZ3  1 
ATOM   2100 N N    . GLY A 1 138 ? 2.326   7.858   11.341  1.00 40.10  ? 138 GLY A N    1 
ATOM   2101 C CA   . GLY A 1 138 ? 2.807   8.959   10.559  1.00 43.95  ? 138 GLY A CA   1 
ATOM   2102 C C    . GLY A 1 138 ? 4.256   8.800   10.155  1.00 40.46  ? 138 GLY A C    1 
ATOM   2103 O O    . GLY A 1 138 ? 4.807   7.693   10.110  1.00 38.17  ? 138 GLY A O    1 
ATOM   2104 H H    . GLY A 1 138 ? 2.639   7.843   12.142  1.00 48.18  ? 138 GLY A H    1 
ATOM   2105 H HA2  . GLY A 1 138 ? 2.273   9.035   9.753   1.00 52.80  ? 138 GLY A HA2  1 
ATOM   2106 H HA3  . GLY A 1 138 ? 2.722   9.777   11.073  1.00 52.80  ? 138 GLY A HA3  1 
ATOM   2107 N N    . SER A 1 139 ? 4.885   9.929   9.848   1.00 34.82  ? 139 SER A N    1 
ATOM   2108 C CA   . SER A 1 139 ? 6.304   9.967   9.497   1.00 35.99  ? 139 SER A CA   1 
ATOM   2109 C C    . SER A 1 139 ? 6.857   11.233  10.143  1.00 36.55  ? 139 SER A C    1 
ATOM   2110 O O    . SER A 1 139 ? 6.633   12.341  9.645   1.00 33.50  ? 139 SER A O    1 
ATOM   2111 C CB   . SER A 1 139 ? 6.514   9.958   7.993   1.00 41.10  ? 139 SER A CB   1 
ATOM   2112 O OG   . SER A 1 139 ? 7.884   10.136  7.679   1.00 41.49  ? 139 SER A OG   1 
ATOM   2113 H H    . SER A 1 139 ? 4.506   10.701  9.835   1.00 41.85  ? 139 SER A H    1 
ATOM   2114 H HA   . SER A 1 139 ? 6.763   9.191   9.855   1.00 43.24  ? 139 SER A HA   1 
ATOM   2115 H HB2  . SER A 1 139 ? 6.215   9.107   7.636   1.00 49.38  ? 139 SER A HB2  1 
ATOM   2116 H HB3  . SER A 1 139 ? 6.002   10.681  7.597   1.00 49.38  ? 139 SER A HB3  1 
ATOM   2117 H HG   . SER A 1 139 ? 7.963   10.464  6.910   1.00 49.85  ? 139 SER A HG   1 
ATOM   2118 N N    . PHE A 1 140 ? 7.557   11.061  11.263  1.00 39.77  ? 140 PHE A N    1 
ATOM   2119 C CA   . PHE A 1 140 ? 7.973   12.175  12.102  1.00 37.98  ? 140 PHE A CA   1 
ATOM   2120 C C    . PHE A 1 140 ? 9.362   11.900  12.653  1.00 49.70  ? 140 PHE A C    1 
ATOM   2121 O O    . PHE A 1 140 ? 9.620   10.799  13.148  1.00 44.42  ? 140 PHE A O    1 
ATOM   2122 C CB   . PHE A 1 140 ? 7.017   12.376  13.284  1.00 41.63  ? 140 PHE A CB   1 
ATOM   2123 C CG   . PHE A 1 140 ? 5.649   12.869  12.913  1.00 34.92  ? 140 PHE A CG   1 
ATOM   2124 C CD1  . PHE A 1 140 ? 5.443   14.187  12.546  1.00 41.88  ? 140 PHE A CD1  1 
ATOM   2125 C CD2  . PHE A 1 140 ? 4.558   12.021  12.992  1.00 43.47  ? 140 PHE A CD2  1 
ATOM   2126 C CE1  . PHE A 1 140 ? 4.174   14.642  12.237  1.00 36.04  ? 140 PHE A CE1  1 
ATOM   2127 C CE2  . PHE A 1 140 ? 3.291   12.469  12.683  1.00 44.61  ? 140 PHE A CE2  1 
ATOM   2128 C CZ   . PHE A 1 140 ? 3.097   13.783  12.308  1.00 35.72  ? 140 PHE A CZ   1 
ATOM   2129 H H    . PHE A 1 140 ? 7.807   10.293  11.560  1.00 47.79  ? 140 PHE A H    1 
ATOM   2130 H HA   . PHE A 1 140 ? 7.992   12.979  11.560  1.00 45.63  ? 140 PHE A HA   1 
ATOM   2131 H HB2  . PHE A 1 140 ? 6.907   11.527  13.738  1.00 50.01  ? 140 PHE A HB2  1 
ATOM   2132 H HB3  . PHE A 1 140 ? 7.407   13.028  13.887  1.00 50.01  ? 140 PHE A HB3  1 
ATOM   2133 H HD1  . PHE A 1 140 ? 6.164   14.772  12.506  1.00 50.31  ? 140 PHE A HD1  1 
ATOM   2134 H HD2  . PHE A 1 140 ? 4.680   11.138  13.257  1.00 52.22  ? 140 PHE A HD2  1 
ATOM   2135 H HE1  . PHE A 1 140 ? 4.046   15.528  11.981  1.00 43.30  ? 140 PHE A HE1  1 
ATOM   2136 H HE2  . PHE A 1 140 ? 2.567   11.887  12.726  1.00 53.59  ? 140 PHE A HE2  1 
ATOM   2137 H HZ   . PHE A 1 140 ? 2.243   14.088  12.104  1.00 42.92  ? 140 PHE A HZ   1 
ATOM   2138 N N    . LEU A 1 141 ? 10.228  12.902  12.617  1.00 43.51  ? 141 LEU A N    1 
ATOM   2139 C CA   . LEU A 1 141 ? 11.556  12.815  13.204  1.00 45.97  ? 141 LEU A CA   1 
ATOM   2140 C C    . LEU A 1 141 ? 11.692  13.858  14.312  1.00 47.26  ? 141 LEU A C    1 
ATOM   2141 O O    . LEU A 1 141 ? 10.770  14.630  14.589  1.00 41.75  ? 141 LEU A O    1 
ATOM   2142 C CB   . LEU A 1 141 ? 12.635  13.008  12.135  1.00 50.17  ? 141 LEU A CB   1 
ATOM   2143 C CG   . LEU A 1 141 ? 12.538  12.122  10.894  1.00 45.85  ? 141 LEU A CG   1 
ATOM   2144 C CD1  . LEU A 1 141 ? 13.462  12.651  9.805   1.00 46.61  ? 141 LEU A CD1  1 
ATOM   2145 C CD2  . LEU A 1 141 ? 12.868  10.677  11.225  1.00 52.09  ? 141 LEU A CD2  1 
ATOM   2146 H H    . LEU A 1 141 ? 10.064  13.661  12.249  1.00 52.26  ? 141 LEU A H    1 
ATOM   2147 H HA   . LEU A 1 141 ? 11.673  11.936  13.597  1.00 55.22  ? 141 LEU A HA   1 
ATOM   2148 H HB2  . LEU A 1 141 ? 12.595  13.928  11.832  1.00 60.26  ? 141 LEU A HB2  1 
ATOM   2149 H HB3  . LEU A 1 141 ? 13.497  12.831  12.544  1.00 60.26  ? 141 LEU A HB3  1 
ATOM   2150 H HG   . LEU A 1 141 ? 11.627  12.141  10.563  1.00 55.07  ? 141 LEU A HG   1 
ATOM   2151 H HD11 . LEU A 1 141 ? 13.794  11.904  9.282   1.00 55.99  ? 141 LEU A HD11 1 
ATOM   2152 H HD12 . LEU A 1 141 ? 12.964  13.258  9.235   1.00 55.99  ? 141 LEU A HD12 1 
ATOM   2153 H HD13 . LEU A 1 141 ? 14.203  13.120  10.220  1.00 55.99  ? 141 LEU A HD13 1 
ATOM   2154 H HD21 . LEU A 1 141 ? 12.777  10.141  10.422  1.00 62.57  ? 141 LEU A HD21 1 
ATOM   2155 H HD22 . LEU A 1 141 ? 13.780  10.629  11.553  1.00 62.57  ? 141 LEU A HD22 1 
ATOM   2156 H HD23 . LEU A 1 141 ? 12.254  10.360  11.906  1.00 62.57  ? 141 LEU A HD23 1 
ATOM   2157 N N    . ASN A 1 142 ? 12.855  13.869  14.958  1.00 42.79  ? 142 ASN A N    1 
ATOM   2158 C CA   . ASN A 1 142 ? 13.129  14.884  15.965  1.00 38.43  ? 142 ASN A CA   1 
ATOM   2159 C C    . ASN A 1 142 ? 12.971  16.271  15.354  1.00 42.95  ? 142 ASN A C    1 
ATOM   2160 O O    . ASN A 1 142 ? 13.419  16.529  14.234  1.00 43.73  ? 142 ASN A O    1 
ATOM   2161 C CB   . ASN A 1 142 ? 14.537  14.707  16.534  1.00 48.97  ? 142 ASN A CB   1 
ATOM   2162 C CG   . ASN A 1 142 ? 14.660  13.476  17.414  1.00 60.30  ? 142 ASN A CG   1 
ATOM   2163 O OD1  . ASN A 1 142 ? 13.717  12.695  17.551  1.00 63.51  ? 142 ASN A OD1  1 
ATOM   2164 N ND2  . ASN A 1 142 ? 15.830  13.297  18.014  1.00 73.12  ? 142 ASN A ND2  1 
ATOM   2165 H H    . ASN A 1 142 ? 13.493  13.306  14.832  1.00 51.41  ? 142 ASN A H    1 
ATOM   2166 H HA   . ASN A 1 142 ? 12.503  14.795  16.701  1.00 46.17  ? 142 ASN A HA   1 
ATOM   2167 H HB2  . ASN A 1 142 ? 15.166  14.617  15.801  1.00 58.82  ? 142 ASN A HB2  1 
ATOM   2168 H HB3  . ASN A 1 142 ? 14.762  15.483  17.071  1.00 58.82  ? 142 ASN A HB3  1 
ATOM   2169 H HD21 . ASN A 1 142 ? 16.466  13.863  17.894  1.00 87.80  ? 142 ASN A HD21 1 
ATOM   2170 H HD22 . ASN A 1 142 ? 15.952  12.615  18.524  1.00 87.80  ? 142 ASN A HD22 1 
ATOM   2171 N N    . GLY A 1 143 ? 12.317  17.162  16.094  1.00 41.46  ? 143 GLY A N    1 
ATOM   2172 C CA   . GLY A 1 143 ? 12.016  18.487  15.605  1.00 35.73  ? 143 GLY A CA   1 
ATOM   2173 C C    . GLY A 1 143 ? 10.682  18.625  14.907  1.00 41.63  ? 143 GLY A C    1 
ATOM   2174 O O    . GLY A 1 143 ? 10.317  19.743  14.522  1.00 46.20  ? 143 GLY A O    1 
ATOM   2175 H H    . GLY A 1 143 ? 12.036  17.013  16.893  1.00 49.81  ? 143 GLY A H    1 
ATOM   2176 H HA2  . GLY A 1 143 ? 12.021  19.102  16.355  1.00 42.93  ? 143 GLY A HA2  1 
ATOM   2177 H HA3  . GLY A 1 143 ? 12.706  18.749  14.977  1.00 42.93  ? 143 GLY A HA3  1 
ATOM   2178 N N    . SER A 1 144 ? 9.939   17.534  14.730  1.00 38.25  ? 144 SER A N    1 
ATOM   2179 C CA   . SER A 1 144 ? 8.657   17.610  14.046  1.00 41.16  ? 144 SER A CA   1 
ATOM   2180 C C    . SER A 1 144 ? 7.514   18.011  14.968  1.00 41.22  ? 144 SER A C    1 
ATOM   2181 O O    . SER A 1 144 ? 6.443   18.371  14.469  1.00 37.28  ? 144 SER A O    1 
ATOM   2182 C CB   . SER A 1 144 ? 8.323   16.270  13.385  1.00 39.90  ? 144 SER A CB   1 
ATOM   2183 O OG   . SER A 1 144 ? 8.213   15.235  14.345  1.00 46.65  ? 144 SER A OG   1 
ATOM   2184 H H    . SER A 1 144 ? 10.156  16.746  14.996  1.00 45.96  ? 144 SER A H    1 
ATOM   2185 H HA   . SER A 1 144 ? 8.728   18.277  13.345  1.00 49.45  ? 144 SER A HA   1 
ATOM   2186 H HB2  . SER A 1 144 ? 7.478   16.353  12.916  1.00 47.94  ? 144 SER A HB2  1 
ATOM   2187 H HB3  . SER A 1 144 ? 9.029   16.044  12.759  1.00 47.94  ? 144 SER A HB3  1 
ATOM   2188 H HG   . SER A 1 144 ? 8.926   15.175  14.786  1.00 56.03  ? 144 SER A HG   1 
ATOM   2189 N N    . ALA A 1 145 ? 7.705   17.948  16.286  1.00 38.14  ? 145 ALA A N    1 
ATOM   2190 C CA   . ALA A 1 145 ? 6.656   18.358  17.208  1.00 40.75  ? 145 ALA A CA   1 
ATOM   2191 C C    . ALA A 1 145 ? 6.182   19.762  16.856  1.00 39.88  ? 145 ALA A C    1 
ATOM   2192 O O    . ALA A 1 145 ? 6.958   20.606  16.398  1.00 37.34  ? 145 ALA A O    1 
ATOM   2193 C CB   . ALA A 1 145 ? 7.153   18.313  18.652  1.00 41.78  ? 145 ALA A CB   1 
ATOM   2194 H H    . ALA A 1 145 ? 8.427   17.674  16.665  1.00 45.82  ? 145 ALA A H    1 
ATOM   2195 H HA   . ALA A 1 145 ? 5.905   17.747  17.140  1.00 48.95  ? 145 ALA A HA   1 
ATOM   2196 H HB1  . ALA A 1 145 ? 6.427   18.565  19.244  1.00 50.20  ? 145 ALA A HB1  1 
ATOM   2197 H HB2  . ALA A 1 145 ? 7.449   17.412  18.856  1.00 50.20  ? 145 ALA A HB2  1 
ATOM   2198 H HB3  . ALA A 1 145 ? 7.892   18.934  18.751  1.00 50.20  ? 145 ALA A HB3  1 
ATOM   2199 N N    . GLY A 1 146 ? 4.892   20.008  17.064  1.00 30.85  ? 146 GLY A N    1 
ATOM   2200 C CA   . GLY A 1 146 ? 4.262   21.221  16.608  1.00 40.32  ? 146 GLY A CA   1 
ATOM   2201 C C    . GLY A 1 146 ? 3.608   21.125  15.245  1.00 34.25  ? 146 GLY A C    1 
ATOM   2202 O O    . GLY A 1 146 ? 2.732   21.943  14.939  1.00 36.97  ? 146 GLY A O    1 
ATOM   2203 H H    . GLY A 1 146 ? 4.360   19.472  17.475  1.00 37.07  ? 146 GLY A H    1 
ATOM   2204 H HA2  . GLY A 1 146 ? 3.578   21.474  17.247  1.00 48.44  ? 146 GLY A HA2  1 
ATOM   2205 H HA3  . GLY A 1 146 ? 4.931   21.922  16.566  1.00 48.44  ? 146 GLY A HA3  1 
ATOM   2206 N N    . SER A 1 147 ? 4.011   20.167  14.411  1.00 36.21  ? 147 SER A N    1 
ATOM   2207 C CA   . SER A 1 147 ? 3.302   19.934  13.159  1.00 30.64  ? 147 SER A CA   1 
ATOM   2208 C C    . SER A 1 147 ? 1.837   19.634  13.456  1.00 37.53  ? 147 SER A C    1 
ATOM   2209 O O    . SER A 1 147 ? 1.503   19.057  14.496  1.00 41.46  ? 147 SER A O    1 
ATOM   2210 C CB   . SER A 1 147 ? 3.920   18.766  12.391  1.00 32.93  ? 147 SER A CB   1 
ATOM   2211 O OG   . SER A 1 147 ? 5.283   19.000  12.090  1.00 34.20  ? 147 SER A OG   1 
ATOM   2212 H H    . SER A 1 147 ? 4.682   19.647  14.546  1.00 43.51  ? 147 SER A H    1 
ATOM   2213 H HA   . SER A 1 147 ? 3.364   20.722  12.596  1.00 36.83  ? 147 SER A HA   1 
ATOM   2214 H HB2  . SER A 1 147 ? 3.853   17.965  12.933  1.00 39.57  ? 147 SER A HB2  1 
ATOM   2215 H HB3  . SER A 1 147 ? 3.433   18.645  11.560  1.00 39.57  ? 147 SER A HB3  1 
ATOM   2216 H HG   . SER A 1 147 ? 5.720   19.105  12.800  1.00 41.10  ? 147 SER A HG   1 
ATOM   2217 N N    . VAL A 1 148 ? 0.952   20.017  12.536  1.00 37.39  ? 148 VAL A N    1 
ATOM   2218 C CA   . VAL A 1 148 ? -0.477  19.884  12.788  1.00 32.19  ? 148 VAL A CA   1 
ATOM   2219 C C    . VAL A 1 148 ? -1.128  18.991  11.744  1.00 41.51  ? 148 VAL A C    1 
ATOM   2220 O O    . VAL A 1 148 ? -0.679  18.890  10.599  1.00 40.55  ? 148 VAL A O    1 
ATOM   2221 C CB   . VAL A 1 148 ? -1.200  21.254  12.832  1.00 37.30  ? 148 VAL A CB   1 
ATOM   2222 C CG1  . VAL A 1 148 ? -0.725  22.061  14.031  1.00 39.50  ? 148 VAL A CG1  1 
ATOM   2223 C CG2  . VAL A 1 148 ? -0.998  22.026  11.534  1.00 33.88  ? 148 VAL A CG2  1 
ATOM   2224 H H    . VAL A 1 148 ? 1.155   20.351  11.770  1.00 44.93  ? 148 VAL A H    1 
ATOM   2225 H HA   . VAL A 1 148 ? -0.573  19.447  13.648  1.00 38.68  ? 148 VAL A HA   1 
ATOM   2226 H HB   . VAL A 1 148 ? -2.153  21.100  12.928  1.00 44.82  ? 148 VAL A HB   1 
ATOM   2227 H HG11 . VAL A 1 148 ? -1.183  22.916  14.038  1.00 47.46  ? 148 VAL A HG11 1 
ATOM   2228 H HG12 . VAL A 1 148 ? -0.929  21.570  14.843  1.00 47.46  ? 148 VAL A HG12 1 
ATOM   2229 H HG13 . VAL A 1 148 ? 0.232   22.199  13.960  1.00 47.46  ? 148 VAL A HG13 1 
ATOM   2230 H HG21 . VAL A 1 148 ? -1.427  22.892  11.613  1.00 40.71  ? 148 VAL A HG21 1 
ATOM   2231 H HG22 . VAL A 1 148 ? -0.047  22.140  11.379  1.00 40.71  ? 148 VAL A HG22 1 
ATOM   2232 H HG23 . VAL A 1 148 ? -1.394  21.525  10.804  1.00 40.71  ? 148 VAL A HG23 1 
ATOM   2233 N N    . GLY A 1 149 ? -2.203  18.331  12.164  1.00 37.39  ? 149 GLY A N    1 
ATOM   2234 C CA   . GLY A 1 149 ? -3.089  17.608  11.271  1.00 36.05  ? 149 GLY A CA   1 
ATOM   2235 C C    . GLY A 1 149 ? -4.360  18.415  11.099  1.00 45.01  ? 149 GLY A C    1 
ATOM   2236 O O    . GLY A 1 149 ? -4.770  19.150  12.005  1.00 34.48  ? 149 GLY A O    1 
ATOM   2237 H H    . GLY A 1 149 ? -2.444  18.289  12.989  1.00 44.93  ? 149 GLY A H    1 
ATOM   2238 H HA2  . GLY A 1 149 ? -2.667  17.483  10.406  1.00 43.32  ? 149 GLY A HA2  1 
ATOM   2239 H HA3  . GLY A 1 149 ? -3.307  16.739  11.644  1.00 43.32  ? 149 GLY A HA3  1 
ATOM   2240 N N    . PHE A 1 150 ? -4.986  18.284  9.935   1.00 34.16  ? 150 PHE A N    1 
ATOM   2241 C CA   . PHE A 1 150 ? -6.106  19.154  9.614   1.00 38.96  ? 150 PHE A CA   1 
ATOM   2242 C C    . PHE A 1 150 ? -6.939  18.562  8.489   1.00 38.44  ? 150 PHE A C    1 
ATOM   2243 O O    . PHE A 1 150 ? -6.479  17.719  7.718   1.00 39.26  ? 150 PHE A O    1 
ATOM   2244 C CB   . PHE A 1 150 ? -5.617  20.548  9.199   1.00 42.90  ? 150 PHE A CB   1 
ATOM   2245 C CG   . PHE A 1 150 ? -4.739  20.534  7.973   1.00 37.45  ? 150 PHE A CG   1 
ATOM   2246 C CD1  . PHE A 1 150 ? -3.377  20.319  8.088   1.00 39.53  ? 150 PHE A CD1  1 
ATOM   2247 C CD2  . PHE A 1 150 ? -5.278  20.724  6.708   1.00 43.13  ? 150 PHE A CD2  1 
ATOM   2248 C CE1  . PHE A 1 150 ? -2.566  20.299  6.969   1.00 42.95  ? 150 PHE A CE1  1 
ATOM   2249 C CE2  . PHE A 1 150 ? -4.470  20.706  5.584   1.00 47.34  ? 150 PHE A CE2  1 
ATOM   2250 C CZ   . PHE A 1 150 ? -3.112  20.492  5.716   1.00 46.83  ? 150 PHE A CZ   1 
ATOM   2251 H H    . PHE A 1 150 ? -4.784  17.710  9.327   1.00 41.05  ? 150 PHE A H    1 
ATOM   2252 H HA   . PHE A 1 150 ? -6.671  19.216  10.400  1.00 46.81  ? 150 PHE A HA   1 
ATOM   2253 H HB2  . PHE A 1 150 ? -6.387  21.106  9.008   1.00 51.54  ? 150 PHE A HB2  1 
ATOM   2254 H HB3  . PHE A 1 150 ? -5.104  20.930  9.928   1.00 51.54  ? 150 PHE A HB3  1 
ATOM   2255 H HD1  . PHE A 1 150 ? -3.003  20.186  8.929   1.00 47.49  ? 150 PHE A HD1  1 
ATOM   2256 H HD2  . PHE A 1 150 ? -6.192  20.866  6.615   1.00 51.82  ? 150 PHE A HD2  1 
ATOM   2257 H HE1  . PHE A 1 150 ? -1.652  20.156  7.060   1.00 51.60  ? 150 PHE A HE1  1 
ATOM   2258 H HE2  . PHE A 1 150 ? -4.842  20.837  4.742   1.00 56.87  ? 150 PHE A HE2  1 
ATOM   2259 H HZ   . PHE A 1 150 ? -2.567  20.478  4.962   1.00 56.26  ? 150 PHE A HZ   1 
ATOM   2260 N N    . ASN A 1 151 ? -8.179  19.034  8.413   1.00 36.79  ? 151 ASN A N    1 
ATOM   2261 C CA   . ASN A 1 151 ? -9.070  18.842  7.282   1.00 38.86  ? 151 ASN A CA   1 
ATOM   2262 C C    . ASN A 1 151 ? -9.476  20.223  6.786   1.00 46.69  ? 151 ASN A C    1 
ATOM   2263 O O    . ASN A 1 151 ? -9.326  21.221  7.494   1.00 44.76  ? 151 ASN A O    1 
ATOM   2264 C CB   . ASN A 1 151 ? -10.288 18.013  7.681   1.00 37.00  ? 151 ASN A CB   1 
ATOM   2265 C CG   . ASN A 1 151 ? -9.981  16.529  7.737   1.00 50.99  ? 151 ASN A CG   1 
ATOM   2266 O OD1  . ASN A 1 151 ? -9.711  15.899  6.717   1.00 41.39  ? 151 ASN A OD1  1 
ATOM   2267 N ND2  . ASN A 1 151 ? -10.002 15.966  8.939   1.00 45.75  ? 151 ASN A ND2  1 
ATOM   2268 H H    . ASN A 1 151 ? -8.544  19.494  9.042   1.00 44.20  ? 151 ASN A H    1 
ATOM   2269 H HA   . ASN A 1 151 ? -8.636  18.364  6.558   1.00 46.69  ? 151 ASN A HA   1 
ATOM   2270 H HB2  . ASN A 1 151 ? -10.589 18.293  8.559   1.00 44.45  ? 151 ASN A HB2  1 
ATOM   2271 H HB3  . ASN A 1 151 ? -10.993 18.150  7.029   1.00 44.45  ? 151 ASN A HB3  1 
ATOM   2272 H HD21 . ASN A 1 151 ? -10.183 16.440  9.634   1.00 54.96  ? 151 ASN A HD21 1 
ATOM   2273 H HD22 . ASN A 1 151 ? -9.834  15.126  9.024   1.00 54.96  ? 151 ASN A HD22 1 
ATOM   2274 N N    . ILE A 1 152 ? -9.976  20.292  5.558   1.00 42.41  ? 152 ILE A N    1 
ATOM   2275 C CA   . ILE A 1 152 ? -10.440 21.553  4.989   1.00 51.45  ? 152 ILE A CA   1 
ATOM   2276 C C    . ILE A 1 152 ? -11.807 21.317  4.363   1.00 53.96  ? 152 ILE A C    1 
ATOM   2277 O O    . ILE A 1 152 ? -11.962 20.428  3.517   1.00 55.33  ? 152 ILE A O    1 
ATOM   2278 C CB   . ILE A 1 152 ? -9.461  22.126  3.950   1.00 51.21  ? 152 ILE A CB   1 
ATOM   2279 C CG1  . ILE A 1 152 ? -8.034  22.138  4.508   1.00 49.69  ? 152 ILE A CG1  1 
ATOM   2280 C CG2  . ILE A 1 152 ? -9.879  23.540  3.550   1.00 60.94  ? 152 ILE A CG2  1 
ATOM   2281 C CD1  . ILE A 1 152 ? -7.040  22.921  3.665   1.00 46.49  ? 152 ILE A CD1  1 
ATOM   2282 H H    . ILE A 1 152 ? -10.057 19.618  5.030   1.00 50.95  ? 152 ILE A H    1 
ATOM   2283 H HA   . ILE A 1 152 ? -10.538 22.203  5.703   1.00 61.79  ? 152 ILE A HA   1 
ATOM   2284 H HB   . ILE A 1 152 ? -9.483  21.556  3.165   1.00 61.51  ? 152 ILE A HB   1 
ATOM   2285 H HG12 . ILE A 1 152 ? -8.051  22.539  5.391   1.00 59.69  ? 152 ILE A HG12 1 
ATOM   2286 H HG13 . ILE A 1 152 ? -7.716  21.224  4.565   1.00 59.69  ? 152 ILE A HG13 1 
ATOM   2287 H HG21 . ILE A 1 152 ? -9.325  23.836  2.810   1.00 73.19  ? 152 ILE A HG21 1 
ATOM   2288 H HG22 . ILE A 1 152 ? -10.811 23.530  3.282   1.00 73.19  ? 152 ILE A HG22 1 
ATOM   2289 H HG23 . ILE A 1 152 ? -9.759  24.132  4.309   1.00 73.19  ? 152 ILE A HG23 1 
ATOM   2290 H HD11 . ILE A 1 152 ? -6.141  22.729  3.977   1.00 55.85  ? 152 ILE A HD11 1 
ATOM   2291 H HD12 . ILE A 1 152 ? -7.132  22.653  2.737   1.00 55.85  ? 152 ILE A HD12 1 
ATOM   2292 H HD13 . ILE A 1 152 ? -7.226  23.869  3.756   1.00 55.85  ? 152 ILE A HD13 1 
ATOM   2293 N N    . ASP A 1 153 ? -12.796 22.098  4.792   1.00 72.90  ? 153 ASP A N    1 
ATOM   2294 C CA   . ASP A 1 153 ? -14.146 22.072  4.242   1.00 68.47  ? 153 ASP A CA   1 
ATOM   2295 C C    . ASP A 1 153 ? -14.531 23.498  3.877   1.00 68.22  ? 153 ASP A C    1 
ATOM   2296 O O    . ASP A 1 153 ? -14.454 24.398  4.720   1.00 68.84  ? 153 ASP A O    1 
ATOM   2297 C CB   . ASP A 1 153 ? -15.147 21.490  5.244   1.00 66.05  ? 153 ASP A CB   1 
ATOM   2298 H H    . ASP A 1 153 ? -12.704 22.673  5.425   1.00 87.54  ? 153 ASP A H    1 
ATOM   2299 H HA   . ASP A 1 153 ? -14.172 21.520  3.445   1.00 82.22  ? 153 ASP A HA   1 
ATOM   2300 N N    . TYR A 1 154 ? -14.940 23.705  2.627   1.00 72.41  ? 154 TYR A N    1 
ATOM   2301 C CA   . TYR A 1 154 ? -15.212 25.045  2.100   1.00 65.16  ? 154 TYR A CA   1 
ATOM   2302 C C    . TYR A 1 154 ? -13.916 25.834  2.237   1.00 63.85  ? 154 TYR A C    1 
ATOM   2303 O O    . TYR A 1 154 ? -12.888 25.389  1.696   1.00 63.70  ? 154 TYR A O    1 
ATOM   2304 C CB   . TYR A 1 154 ? -16.433 25.628  2.813   1.00 58.75  ? 154 TYR A CB   1 
ATOM   2305 H H    . TYR A 1 154 ? -15.069 23.076  2.055   1.00 86.95  ? 154 TYR A H    1 
ATOM   2306 H HA   . TYR A 1 154 ? -15.431 24.984  1.157   1.00 78.25  ? 154 TYR A HA   1 
ATOM   2307 N N    . ASP A 1 155 ? -13.892 26.962  2.940   1.00 61.04  ? 155 ASP A N    1 
ATOM   2308 C CA   . ASP A 1 155 ? -12.671 27.734  3.134   1.00 74.17  ? 155 ASP A CA   1 
ATOM   2309 C C    . ASP A 1 155 ? -12.066 27.552  4.521   1.00 66.93  ? 155 ASP A C    1 
ATOM   2310 O O    . ASP A 1 155 ? -11.050 28.184  4.826   1.00 57.67  ? 155 ASP A O    1 
ATOM   2311 C CB   . ASP A 1 155 ? -12.950 29.221  2.882   1.00 86.97  ? 155 ASP A CB   1 
ATOM   2312 H H    . ASP A 1 155 ? -14.583 27.306  3.321   1.00 73.31  ? 155 ASP A H    1 
ATOM   2313 H HA   . ASP A 1 155 ? -12.012 27.438  2.486   1.00 89.06  ? 155 ASP A HA   1 
ATOM   2314 N N    . CYS A 1 156 ? -12.642 26.685  5.349   1.00 58.40  ? 156 CYS A N    1 
ATOM   2315 C CA   . CYS A 1 156 ? -12.286 26.579  6.758   1.00 55.32  ? 156 CYS A CA   1 
ATOM   2316 C C    . CYS A 1 156 ? -11.328 25.421  7.002   1.00 47.55  ? 156 CYS A C    1 
ATOM   2317 O O    . CYS A 1 156 ? -11.606 24.283  6.609   1.00 45.72  ? 156 CYS A O    1 
ATOM   2318 C CB   . CYS A 1 156 ? -13.543 26.391  7.608   1.00 60.07  ? 156 CYS A CB   1 
ATOM   2319 S SG   . CYS A 1 156 ? -13.238 26.308  9.380   1.00 49.45  ? 156 CYS A SG   1 
ATOM   2320 H H    . CYS A 1 156 ? -13.258 26.134  5.111   1.00 70.14  ? 156 CYS A H    1 
ATOM   2321 H HA   . CYS A 1 156 ? -11.829 27.393  7.021   1.00 66.44  ? 156 CYS A HA   1 
ATOM   2322 H HB2  . CYS A 1 156 ? -14.139 27.139  7.447   1.00 72.15  ? 156 CYS A HB2  1 
ATOM   2323 H HB3  . CYS A 1 156 ? -13.973 25.562  7.345   1.00 72.15  ? 156 CYS A HB3  1 
ATOM   2324 H HG   . CYS A 1 156 ? -14.276 26.104  9.946   1.00 59.40  ? 156 CYS A HG   1 
ATOM   2325 N N    . VAL A 1 157 ? -10.216 25.714  7.668   1.00 45.18  ? 157 VAL A N    1 
ATOM   2326 C CA   . VAL A 1 157 ? -9.275  24.696  8.126   1.00 43.00  ? 157 VAL A CA   1 
ATOM   2327 C C    . VAL A 1 157 ? -9.716  24.239  9.512   1.00 47.25  ? 157 VAL A C    1 
ATOM   2328 O O    . VAL A 1 157 ? -9.783  25.044  10.446  1.00 39.06  ? 157 VAL A O    1 
ATOM   2329 C CB   . VAL A 1 157 ? -7.838  25.243  8.152   1.00 46.78  ? 157 VAL A CB   1 
ATOM   2330 C CG1  . VAL A 1 157 ? -6.852  24.171  8.598   1.00 35.23  ? 157 VAL A CG1  1 
ATOM   2331 C CG2  . VAL A 1 157 ? -7.462  25.807  6.782   1.00 47.44  ? 157 VAL A CG2  1 
ATOM   2332 H H    . VAL A 1 157 ? -9.978  26.515  7.873   1.00 54.27  ? 157 VAL A H    1 
ATOM   2333 H HA   . VAL A 1 157 ? -9.300  23.934  7.526   1.00 51.66  ? 157 VAL A HA   1 
ATOM   2334 H HB   . VAL A 1 157 ? -7.790  25.964  8.798   1.00 56.19  ? 157 VAL A HB   1 
ATOM   2335 H HG11 . VAL A 1 157 ? -5.951  24.525  8.533   1.00 42.33  ? 157 VAL A HG11 1 
ATOM   2336 H HG12 . VAL A 1 157 ? -7.046  23.926  9.516   1.00 42.33  ? 157 VAL A HG12 1 
ATOM   2337 H HG13 . VAL A 1 157 ? -6.945  23.396  8.022   1.00 42.33  ? 157 VAL A HG13 1 
ATOM   2338 H HG21 . VAL A 1 157 ? -6.534  26.089  6.801   1.00 56.99  ? 157 VAL A HG21 1 
ATOM   2339 H HG22 . VAL A 1 157 ? -7.583  25.116  6.112   1.00 56.99  ? 157 VAL A HG22 1 
ATOM   2340 H HG23 . VAL A 1 157 ? -8.034  26.564  6.584   1.00 56.99  ? 157 VAL A HG23 1 
ATOM   2341 N N    . SER A 1 158 ? -10.029 22.951  9.647   1.00 38.54  ? 158 SER A N    1 
ATOM   2342 C CA   . SER A 1 158 ? -10.406 22.359  10.930  1.00 37.33  ? 158 SER A CA   1 
ATOM   2343 C C    . SER A 1 158 ? -9.179  21.645  11.487  1.00 39.32  ? 158 SER A C    1 
ATOM   2344 O O    . SER A 1 158 ? -8.900  20.501  11.125  1.00 42.08  ? 158 SER A O    1 
ATOM   2345 C CB   . SER A 1 158 ? -11.584 21.401  10.777  1.00 41.52  ? 158 SER A CB   1 
ATOM   2346 O OG   . SER A 1 158 ? -12.810 22.101  10.680  1.00 50.04  ? 158 SER A OG   1 
ATOM   2347 H H    . SER A 1 158 ? -10.030 22.388  8.996   1.00 46.30  ? 158 SER A H    1 
ATOM   2348 H HA   . SER A 1 158 ? -10.670 23.065  11.541  1.00 44.86  ? 158 SER A HA   1 
ATOM   2349 H HB2  . SER A 1 158 ? -11.458 20.875  9.972   1.00 49.89  ? 158 SER A HB2  1 
ATOM   2350 H HB3  . SER A 1 158 ? -11.617 20.818  11.552  1.00 49.89  ? 158 SER A HB3  1 
ATOM   2351 H HG   . SER A 1 158 ? -13.445 21.558  10.601  1.00 60.11  ? 158 SER A HG   1 
ATOM   2352 N N    . PHE A 1 159 ? -8.444  22.328  12.364  1.00 41.26  ? 159 PHE A N    1 
ATOM   2353 C CA   . PHE A 1 159 ? -7.273  21.728  12.990  1.00 40.04  ? 159 PHE A CA   1 
ATOM   2354 C C    . PHE A 1 159 ? -7.710  20.667  13.993  1.00 42.92  ? 159 PHE A C    1 
ATOM   2355 O O    . PHE A 1 159 ? -8.516  20.943  14.886  1.00 36.27  ? 159 PHE A O    1 
ATOM   2356 C CB   . PHE A 1 159 ? -6.443  22.802  13.691  1.00 45.63  ? 159 PHE A CB   1 
ATOM   2357 C CG   . PHE A 1 159 ? -5.784  23.777  12.753  1.00 36.87  ? 159 PHE A CG   1 
ATOM   2358 C CD1  . PHE A 1 159 ? -4.690  23.396  11.995  1.00 35.76  ? 159 PHE A CD1  1 
ATOM   2359 C CD2  . PHE A 1 159 ? -6.250  25.078  12.639  1.00 40.38  ? 159 PHE A CD2  1 
ATOM   2360 C CE1  . PHE A 1 159 ? -4.077  24.290  11.137  1.00 35.44  ? 159 PHE A CE1  1 
ATOM   2361 C CE2  . PHE A 1 159 ? -5.639  25.976  11.782  1.00 37.79  ? 159 PHE A CE2  1 
ATOM   2362 C CZ   . PHE A 1 159 ? -4.550  25.581  11.031  1.00 36.47  ? 159 PHE A CZ   1 
ATOM   2363 H H    . PHE A 1 159 ? -8.603  23.136  12.610  1.00 49.57  ? 159 PHE A H    1 
ATOM   2364 H HA   . PHE A 1 159 ? -6.720  21.308  12.313  1.00 48.11  ? 159 PHE A HA   1 
ATOM   2365 H HB2  . PHE A 1 159 ? -7.024  23.307  14.281  1.00 54.81  ? 159 PHE A HB2  1 
ATOM   2366 H HB3  . PHE A 1 159 ? -5.744  22.368  14.205  1.00 54.81  ? 159 PHE A HB3  1 
ATOM   2367 H HD1  . PHE A 1 159 ? -4.363  22.528  12.064  1.00 42.97  ? 159 PHE A HD1  1 
ATOM   2368 H HD2  . PHE A 1 159 ? -6.982  25.350  13.144  1.00 48.51  ? 159 PHE A HD2  1 
ATOM   2369 H HE1  . PHE A 1 159 ? -3.344  24.021  10.632  1.00 42.58  ? 159 PHE A HE1  1 
ATOM   2370 H HE2  . PHE A 1 159 ? -5.961  26.845  11.713  1.00 45.40  ? 159 PHE A HE2  1 
ATOM   2371 H HZ   . PHE A 1 159 ? -4.138  26.183  10.455  1.00 43.82  ? 159 PHE A HZ   1 
ATOM   2372 N N    . CYS A 1 160 ? -7.171  19.454  13.862  1.00 35.67  ? 160 CYS A N    1 
ATOM   2373 C CA   . CYS A 1 160 ? -7.547  18.368  14.757  1.00 37.54  ? 160 CYS A CA   1 
ATOM   2374 C C    . CYS A 1 160 ? -6.386  17.707  15.487  1.00 33.81  ? 160 CYS A C    1 
ATOM   2375 O O    . CYS A 1 160 ? -6.635  16.857  16.351  1.00 38.68  ? 160 CYS A O    1 
ATOM   2376 C CB   . CYS A 1 160 ? -8.305  17.278  13.982  1.00 37.96  ? 160 CYS A CB   1 
ATOM   2377 S SG   . CYS A 1 160 ? -7.323  16.587  12.643  1.00 39.45  ? 160 CYS A SG   1 
ATOM   2378 H H    . CYS A 1 160 ? -6.590  19.240  13.265  1.00 42.86  ? 160 CYS A H    1 
ATOM   2379 H HA   . CYS A 1 160 ? -8.135  18.740  15.432  1.00 45.11  ? 160 CYS A HA   1 
ATOM   2380 H HB2  . CYS A 1 160 ? -8.536  16.558  14.590  1.00 45.61  ? 160 CYS A HB2  1 
ATOM   2381 H HB3  . CYS A 1 160 ? -9.110  17.661  13.600  1.00 45.61  ? 160 CYS A HB3  1 
ATOM   2382 H HG   . CYS A 1 160 ? -7.976  15.762  12.065  1.00 47.40  ? 160 CYS A HG   1 
ATOM   2383 N N    . TYR A 1 161 ? -5.141  18.060  15.182  1.00 34.16  ? 161 TYR A N    1 
ATOM   2384 C CA   . TYR A 1 161 ? -4.018  17.316  15.729  1.00 33.37  ? 161 TYR A CA   1 
ATOM   2385 C C    . TYR A 1 161 ? -2.784  18.199  15.766  1.00 32.93  ? 161 TYR A C    1 
ATOM   2386 O O    . TYR A 1 161 ? -2.503  18.919  14.808  1.00 34.78  ? 161 TYR A O    1 
ATOM   2387 C CB   . TYR A 1 161 ? -3.731  16.066  14.892  1.00 36.26  ? 161 TYR A CB   1 
ATOM   2388 C CG   . TYR A 1 161 ? -2.576  15.230  15.389  1.00 32.81  ? 161 TYR A CG   1 
ATOM   2389 C CD1  . TYR A 1 161 ? -2.750  14.334  16.431  1.00 39.53  ? 161 TYR A CD1  1 
ATOM   2390 C CD2  . TYR A 1 161 ? -1.318  15.326  14.806  1.00 37.82  ? 161 TYR A CD2  1 
ATOM   2391 C CE1  . TYR A 1 161 ? -1.707  13.560  16.885  1.00 34.03  ? 161 TYR A CE1  1 
ATOM   2392 C CE2  . TYR A 1 161 ? -0.267  14.556  15.256  1.00 32.05  ? 161 TYR A CE2  1 
ATOM   2393 C CZ   . TYR A 1 161 ? -0.467  13.676  16.296  1.00 37.63  ? 161 TYR A CZ   1 
ATOM   2394 O OH   . TYR A 1 161 ? 0.574   12.904  16.751  1.00 37.34  ? 161 TYR A OH   1 
ATOM   2395 H H    . TYR A 1 161 ? -4.927  18.716  14.668  1.00 41.04  ? 161 TYR A H    1 
ATOM   2396 H HA   . TYR A 1 161 ? -4.227  17.055  16.639  1.00 40.10  ? 161 TYR A HA   1 
ATOM   2397 H HB2  . TYR A 1 161 ? -4.522  15.504  14.895  1.00 43.56  ? 161 TYR A HB2  1 
ATOM   2398 H HB3  . TYR A 1 161 ? -3.524  16.342  13.985  1.00 43.56  ? 161 TYR A HB3  1 
ATOM   2399 H HD1  . TYR A 1 161 ? -3.586  14.254  16.831  1.00 47.49  ? 161 TYR A HD1  1 
ATOM   2400 H HD2  . TYR A 1 161 ? -1.183  15.919  14.103  1.00 45.44  ? 161 TYR A HD2  1 
ATOM   2401 H HE1  . TYR A 1 161 ? -1.838  12.963  17.586  1.00 40.89  ? 161 TYR A HE1  1 
ATOM   2402 H HE2  . TYR A 1 161 ? 0.571   14.630  14.859  1.00 38.51  ? 161 TYR A HE2  1 
ATOM   2403 H HH   . TYR A 1 161 ? 1.259   13.043  16.285  1.00 44.86  ? 161 TYR A HH   1 
ATOM   2404 N N    . MET A 1 162 ? -2.057  18.131  16.877  1.00 32.04  ? 162 MET A N    1 
ATOM   2405 C CA   . MET A 1 162 ? -0.708  18.668  16.977  1.00 36.07  ? 162 MET A CA   1 
ATOM   2406 C C    . MET A 1 162 ? 0.205   17.541  17.432  1.00 36.24  ? 162 MET A C    1 
ATOM   2407 O O    . MET A 1 162 ? -0.111  16.831  18.394  1.00 36.96  ? 162 MET A O    1 
ATOM   2408 C CB   . MET A 1 162 ? -0.627  19.838  17.956  1.00 37.76  ? 162 MET A CB   1 
ATOM   2409 C CG   . MET A 1 162 ? 0.778   20.425  18.071  1.00 30.69  ? 162 MET A CG   1 
ATOM   2410 S SD   . MET A 1 162 ? 0.820   22.006  18.938  1.00 40.63  ? 162 MET A SD   1 
ATOM   2411 C CE   . MET A 1 162 ? 0.535   23.152  17.589  1.00 41.79  ? 162 MET A CE   1 
ATOM   2412 H H    . MET A 1 162 ? -2.334  17.768  17.605  1.00 38.51  ? 162 MET A H    1 
ATOM   2413 H HA   . MET A 1 162 ? -0.428  19.005  16.112  1.00 43.34  ? 162 MET A HA   1 
ATOM   2414 H HB2  . MET A 1 162 ? -1.221  20.542  17.654  1.00 45.37  ? 162 MET A HB2  1 
ATOM   2415 H HB3  . MET A 1 162 ? -0.896  19.531  18.836  1.00 45.37  ? 162 MET A HB3  1 
ATOM   2416 H HG2  . MET A 1 162 ? 1.339   19.802  18.559  1.00 36.88  ? 162 MET A HG2  1 
ATOM   2417 H HG3  . MET A 1 162 ? 1.134   20.564  17.180  1.00 36.88  ? 162 MET A HG3  1 
ATOM   2418 H HE1  . MET A 1 162 ? 0.524   24.056  17.940  1.00 50.21  ? 162 MET A HE1  1 
ATOM   2419 H HE2  . MET A 1 162 ? 1.248   23.058  16.938  1.00 50.21  ? 162 MET A HE2  1 
ATOM   2420 H HE3  . MET A 1 162 ? -0.319  22.947  17.176  1.00 50.21  ? 162 MET A HE3  1 
ATOM   2421 N N    . HIS A 1 163 ? 1.330   17.378  16.745  1.00 34.43  ? 163 HIS A N    1 
ATOM   2422 C CA   . HIS A 1 163 ? 2.240   16.285  17.043  1.00 33.93  ? 163 HIS A CA   1 
ATOM   2423 C C    . HIS A 1 163 ? 3.105   16.601  18.253  1.00 33.38  ? 163 HIS A C    1 
ATOM   2424 O O    . HIS A 1 163 ? 3.596   17.723  18.408  1.00 32.28  ? 163 HIS A O    1 
ATOM   2425 C CB   . HIS A 1 163 ? 3.147   15.998  15.850  1.00 29.53  ? 163 HIS A CB   1 
ATOM   2426 C CG   . HIS A 1 163 ? 4.069   14.843  16.072  1.00 30.63  ? 163 HIS A CG   1 
ATOM   2427 N ND1  . HIS A 1 163 ? 3.611   13.582  16.379  1.00 30.57  ? 163 HIS A ND1  1 
ATOM   2428 C CD2  . HIS A 1 163 ? 5.421   14.759  16.052  1.00 31.77  ? 163 HIS A CD2  1 
ATOM   2429 C CE1  . HIS A 1 163 ? 4.640   12.767  16.528  1.00 32.38  ? 163 HIS A CE1  1 
ATOM   2430 N NE2  . HIS A 1 163 ? 5.750   13.456  16.335  1.00 39.47  ? 163 HIS A NE2  1 
ATOM   2431 H H    . HIS A 1 163 ? 1.588   17.889  16.102  1.00 41.37  ? 163 HIS A H    1 
ATOM   2432 H HA   . HIS A 1 163 ? 1.713   15.494  17.237  1.00 40.77  ? 163 HIS A HA   1 
ATOM   2433 H HB2  . HIS A 1 163 ? 2.595   15.794  15.079  1.00 35.50  ? 163 HIS A HB2  1 
ATOM   2434 H HB3  . HIS A 1 163 ? 3.689   16.782  15.672  1.00 35.50  ? 163 HIS A HB3  1 
ATOM   2435 H HD2  . HIS A 1 163 ? 6.015   15.453  15.879  1.00 38.18  ? 163 HIS A HD2  1 
ATOM   2436 H HE1  . HIS A 1 163 ? 4.591   11.861  16.734  1.00 38.91  ? 163 HIS A HE1  1 
ATOM   2437 H HE2  . HIS A 1 163 ? 6.548   13.140  16.379  1.00 47.42  ? 163 HIS A HE2  1 
ATOM   2438 N N    . HIS A 1 164 ? 3.317   15.594  19.093  1.00 34.03  ? 164 HIS A N    1 
ATOM   2439 C CA   . HIS A 1 164 ? 4.143   15.737  20.280  1.00 30.32  ? 164 HIS A CA   1 
ATOM   2440 C C    . HIS A 1 164 ? 5.281   14.734  20.335  1.00 32.47  ? 164 HIS A C    1 
ATOM   2441 O O    . HIS A 1 164 ? 6.425   15.123  20.612  1.00 37.37  ? 164 HIS A O    1 
ATOM   2442 C CB   . HIS A 1 164 ? 3.280   15.584  21.547  1.00 30.58  ? 164 HIS A CB   1 
ATOM   2443 C CG   . HIS A 1 164 ? 2.412   16.765  21.836  1.00 39.43  ? 164 HIS A CG   1 
ATOM   2444 N ND1  . HIS A 1 164 ? 2.611   17.589  22.921  1.00 35.72  ? 164 HIS A ND1  1 
ATOM   2445 C CD2  . HIS A 1 164 ? 1.334   17.257  21.182  1.00 36.46  ? 164 HIS A CD2  1 
ATOM   2446 C CE1  . HIS A 1 164 ? 1.693   18.538  22.924  1.00 32.38  ? 164 HIS A CE1  1 
ATOM   2447 N NE2  . HIS A 1 164 ? 0.907   18.361  21.878  1.00 41.19  ? 164 HIS A NE2  1 
ATOM   2448 H H    . HIS A 1 164 ? 2.987   14.806  18.993  1.00 40.89  ? 164 HIS A H    1 
ATOM   2449 H HA   . HIS A 1 164 ? 4.528   16.627  20.268  1.00 36.45  ? 164 HIS A HA   1 
ATOM   2450 H HB2  . HIS A 1 164 ? 2.702   14.813  21.438  1.00 36.76  ? 164 HIS A HB2  1 
ATOM   2451 H HB3  . HIS A 1 164 ? 3.866   15.455  22.309  1.00 36.76  ? 164 HIS A HB3  1 
ATOM   2452 H HD1  . HIS A 1 164 ? 3.236   17.499  23.505  1.00 42.92  ? 164 HIS A HD1  1 
ATOM   2453 H HD2  . HIS A 1 164 ? 0.954   16.912  20.407  1.00 43.81  ? 164 HIS A HD2  1 
ATOM   2454 H HE1  . HIS A 1 164 ? 1.613   19.216  23.556  1.00 38.91  ? 164 HIS A HE1  1 
ATOM   2455 N N    . MET A 1 165 ? 5.013   13.459  20.072  1.00 33.35  ? 165 MET A N    1 
ATOM   2456 C CA   . MET A 1 165 ? 5.966   12.427  20.450  1.00 29.49  ? 165 MET A CA   1 
ATOM   2457 C C    . MET A 1 165 ? 5.787   11.168  19.616  1.00 32.74  ? 165 MET A C    1 
ATOM   2458 O O    . MET A 1 165 ? 4.791   10.989  18.912  1.00 37.11  ? 165 MET A O    1 
ATOM   2459 C CB   . MET A 1 165 ? 5.807   12.071  21.932  1.00 38.59  ? 165 MET A CB   1 
ATOM   2460 C CG   . MET A 1 165 ? 4.458   11.419  22.242  1.00 40.59  ? 165 MET A CG   1 
ATOM   2461 S SD   . MET A 1 165 ? 4.076   11.423  24.002  1.00 40.62  ? 165 MET A SD   1 
ATOM   2462 C CE   . MET A 1 165 ? 4.294   9.694   24.412  1.00 46.10  ? 165 MET A CE   1 
ATOM   2463 H H    . MET A 1 165 ? 4.301   13.174  19.683  1.00 40.08  ? 165 MET A H    1 
ATOM   2464 H HA   . MET A 1 165 ? 6.851   12.781  20.269  1.00 35.44  ? 165 MET A HA   1 
ATOM   2465 H HB2  . MET A 1 165 ? 6.507   11.448  22.183  1.00 46.37  ? 165 MET A HB2  1 
ATOM   2466 H HB3  . MET A 1 165 ? 5.879   12.881  22.460  1.00 46.37  ? 165 MET A HB3  1 
ATOM   2467 H HG2  . MET A 1 165 ? 3.757   11.907  21.782  1.00 48.77  ? 165 MET A HG2  1 
ATOM   2468 H HG3  . MET A 1 165 ? 4.474   10.498  21.940  1.00 48.77  ? 165 MET A HG3  1 
ATOM   2469 H HE1  . MET A 1 165 ? 3.996   9.545   25.323  1.00 55.37  ? 165 MET A HE1  1 
ATOM   2470 H HE2  . MET A 1 165 ? 3.768   9.155   23.801  1.00 55.37  ? 165 MET A HE2  1 
ATOM   2471 H HE3  . MET A 1 165 ? 5.233   9.466   24.330  1.00 55.37  ? 165 MET A HE3  1 
ATOM   2472 N N    . GLU A 1 166 ? 6.768   10.276  19.748  1.00 37.48  ? 166 GLU A N    1 
ATOM   2473 C CA   . GLU A 1 166 ? 6.775   8.970   19.105  1.00 34.23  ? 166 GLU A CA   1 
ATOM   2474 C C    . GLU A 1 166 ? 6.864   7.894   20.178  1.00 40.01  ? 166 GLU A C    1 
ATOM   2475 O O    . GLU A 1 166 ? 7.719   7.967   21.068  1.00 38.70  ? 166 GLU A O    1 
ATOM   2476 C CB   . GLU A 1 166 ? 7.953   8.846   18.130  1.00 35.24  ? 166 GLU A CB   1 
ATOM   2477 C CG   . GLU A 1 166 ? 8.120   7.462   17.521  1.00 44.56  ? 166 GLU A CG   1 
ATOM   2478 C CD   . GLU A 1 166 ? 9.154   7.422   16.405  1.00 48.71  ? 166 GLU A CD   1 
ATOM   2479 O OE1  . GLU A 1 166 ? 9.147   8.328   15.545  1.00 47.23  ? 166 GLU A OE1  1 
ATOM   2480 O OE2  . GLU A 1 166 ? 9.973   6.476   16.381  1.00 44.83  ? 166 GLU A OE2  1 
ATOM   2481 H H    . GLU A 1 166 ? 7.469   10.414  20.227  1.00 45.04  ? 166 GLU A H    1 
ATOM   2482 H HA   . GLU A 1 166 ? 5.953   8.843   18.607  1.00 41.13  ? 166 GLU A HA   1 
ATOM   2483 H HB2  . GLU A 1 166 ? 7.818   9.472   17.402  1.00 42.34  ? 166 GLU A HB2  1 
ATOM   2484 H HB3  . GLU A 1 166 ? 8.771   9.059   18.604  1.00 42.34  ? 166 GLU A HB3  1 
ATOM   2485 H HG2  . GLU A 1 166 ? 8.404   6.845   18.214  1.00 53.53  ? 166 GLU A HG2  1 
ATOM   2486 H HG3  . GLU A 1 166 ? 7.270   7.176   17.151  1.00 53.53  ? 166 GLU A HG3  1 
ATOM   2487 N N    . LEU A 1 167 ? 5.982   6.904   20.098  1.00 42.07  ? 167 LEU A N    1 
ATOM   2488 C CA   . LEU A 1 167 ? 6.010   5.802   21.045  1.00 37.77  ? 167 LEU A CA   1 
ATOM   2489 C C    . LEU A 1 167 ? 7.031   4.758   20.608  1.00 39.20  ? 167 LEU A C    1 
ATOM   2490 O O    . LEU A 1 167 ? 7.437   4.720   19.443  1.00 41.79  ? 167 LEU A O    1 
ATOM   2491 C CB   . LEU A 1 167 ? 4.627   5.179   21.165  1.00 32.54  ? 167 LEU A CB   1 
ATOM   2492 C CG   . LEU A 1 167 ? 3.559   6.136   21.700  1.00 42.49  ? 167 LEU A CG   1 
ATOM   2493 C CD1  . LEU A 1 167 ? 2.174   5.549   21.462  1.00 44.46  ? 167 LEU A CD1  1 
ATOM   2494 C CD2  . LEU A 1 167 ? 3.772   6.455   23.173  1.00 42.41  ? 167 LEU A CD2  1 
ATOM   2495 H H    . LEU A 1 167 ? 5.360   6.849   19.506  1.00 50.54  ? 167 LEU A H    1 
ATOM   2496 H HA   . LEU A 1 167 ? 6.265   6.125   21.924  1.00 45.38  ? 167 LEU A HA   1 
ATOM   2497 H HB2  . LEU A 1 167 ? 4.344   4.880   20.287  1.00 39.10  ? 167 LEU A HB2  1 
ATOM   2498 H HB3  . LEU A 1 167 ? 4.678   4.424   21.772  1.00 39.10  ? 167 LEU A HB3  1 
ATOM   2499 H HG   . LEU A 1 167 ? 3.626   6.978   21.222  1.00 51.05  ? 167 LEU A HG   1 
ATOM   2500 H HD11 . LEU A 1 167 ? 1.520   6.075   21.949  1.00 53.41  ? 167 LEU A HD11 1 
ATOM   2501 H HD12 . LEU A 1 167 ? 1.978   5.576   20.512  1.00 53.41  ? 167 LEU A HD12 1 
ATOM   2502 H HD13 . LEU A 1 167 ? 2.161   4.632   21.777  1.00 53.41  ? 167 LEU A HD13 1 
ATOM   2503 H HD21 . LEU A 1 167 ? 3.030   6.992   23.490  1.00 50.95  ? 167 LEU A HD21 1 
ATOM   2504 H HD22 . LEU A 1 167 ? 3.818   5.625   23.672  1.00 50.95  ? 167 LEU A HD22 1 
ATOM   2505 H HD23 . LEU A 1 167 ? 4.602   6.947   23.272  1.00 50.95  ? 167 LEU A HD23 1 
ATOM   2506 N N    . PRO A 1 168 ? 7.476   3.902   21.532  1.00 52.78  ? 168 PRO A N    1 
ATOM   2507 C CA   . PRO A 1 168 ? 8.550   2.955   21.183  1.00 59.28  ? 168 PRO A CA   1 
ATOM   2508 C C    . PRO A 1 168 ? 8.235   2.056   19.997  1.00 48.18  ? 168 PRO A C    1 
ATOM   2509 O O    . PRO A 1 168 ? 9.167   1.590   19.329  1.00 54.03  ? 168 PRO A O    1 
ATOM   2510 C CB   . PRO A 1 168 ? 8.740   2.139   22.475  1.00 61.00  ? 168 PRO A CB   1 
ATOM   2511 C CG   . PRO A 1 168 ? 7.560   2.483   23.361  1.00 60.81  ? 168 PRO A CG   1 
ATOM   2512 C CD   . PRO A 1 168 ? 7.159   3.873   22.972  1.00 49.59  ? 168 PRO A CD   1 
ATOM   2513 H HA   . PRO A 1 168 ? 9.360   3.453   20.991  1.00 71.20  ? 168 PRO A HA   1 
ATOM   2514 H HB2  . PRO A 1 168 ? 8.748   1.192   22.265  1.00 73.25  ? 168 PRO A HB2  1 
ATOM   2515 H HB3  . PRO A 1 168 ? 9.574   2.391   22.901  1.00 73.25  ? 168 PRO A HB3  1 
ATOM   2516 H HG2  . PRO A 1 168 ? 6.835   1.858   23.200  1.00 73.03  ? 168 PRO A HG2  1 
ATOM   2517 H HG3  . PRO A 1 168 ? 7.827   2.449   24.292  1.00 73.03  ? 168 PRO A HG3  1 
ATOM   2518 H HD2  . PRO A 1 168 ? 6.212   4.018   23.124  1.00 59.57  ? 168 PRO A HD2  1 
ATOM   2519 H HD3  . PRO A 1 168 ? 7.678   4.534   23.457  1.00 59.57  ? 168 PRO A HD3  1 
ATOM   2520 N N    . THR A 1 169 ? 6.960   1.793   19.706  1.00 47.30  ? 169 THR A N    1 
ATOM   2521 C CA   . THR A 1 169 ? 6.630   0.943   18.569  1.00 46.52  ? 169 THR A CA   1 
ATOM   2522 C C    . THR A 1 169 ? 6.770   1.660   17.231  1.00 51.29  ? 169 THR A C    1 
ATOM   2523 O O    . THR A 1 169 ? 6.620   1.020   16.185  1.00 46.34  ? 169 THR A O    1 
ATOM   2524 C CB   . THR A 1 169 ? 5.203   0.400   18.704  1.00 48.90  ? 169 THR A CB   1 
ATOM   2525 O OG1  . THR A 1 169 ? 4.282   1.487   18.854  1.00 55.35  ? 169 THR A OG1  1 
ATOM   2526 C CG2  . THR A 1 169 ? 5.096   -0.530  19.909  1.00 55.06  ? 169 THR A CG2  1 
ATOM   2527 H H    . THR A 1 169 ? 6.283   2.090   20.145  1.00 56.82  ? 169 THR A H    1 
ATOM   2528 H HA   . THR A 1 169 ? 7.236   0.186   18.570  1.00 55.89  ? 169 THR A HA   1 
ATOM   2529 H HB   . THR A 1 169 ? 4.973   -0.105  17.909  1.00 58.73  ? 169 THR A HB   1 
ATOM   2530 H HG1  . THR A 1 169 ? 3.498   1.193   18.919  1.00 66.47  ? 169 THR A HG1  1 
ATOM   2531 H HG21 . THR A 1 169 ? 4.182   -0.838  20.011  1.00 66.13  ? 169 THR A HG21 1 
ATOM   2532 H HG22 . THR A 1 169 ? 5.675   -1.299  19.788  1.00 66.13  ? 169 THR A HG22 1 
ATOM   2533 H HG23 . THR A 1 169 ? 5.361   -0.061  20.715  1.00 66.13  ? 169 THR A HG23 1 
ATOM   2534 N N    . GLY A 1 170 ? 7.058   2.959   17.234  1.00 44.81  ? 170 GLY A N    1 
ATOM   2535 C CA   . GLY A 1 170 ? 7.184   3.727   16.015  1.00 53.02  ? 170 GLY A CA   1 
ATOM   2536 C C    . GLY A 1 170 ? 5.951   4.518   15.635  1.00 45.60  ? 170 GLY A C    1 
ATOM   2537 O O    . GLY A 1 170 ? 6.019   5.327   14.700  1.00 44.84  ? 170 GLY A O    1 
ATOM   2538 H H    . GLY A 1 170 ? 7.186   3.420   17.948  1.00 53.82  ? 170 GLY A H    1 
ATOM   2539 H HA2  . GLY A 1 170 ? 7.918   4.353   16.117  1.00 63.68  ? 170 GLY A HA2  1 
ATOM   2540 H HA3  . GLY A 1 170 ? 7.384   3.121   15.285  1.00 63.68  ? 170 GLY A HA3  1 
ATOM   2541 N N    . VAL A 1 171 ? 4.830   4.307   16.324  1.00 44.96  ? 171 VAL A N    1 
ATOM   2542 C CA   . VAL A 1 171 ? 3.610   5.070   16.077  1.00 38.51  ? 171 VAL A CA   1 
ATOM   2543 C C    . VAL A 1 171 ? 3.715   6.391   16.827  1.00 38.81  ? 171 VAL A C    1 
ATOM   2544 O O    . VAL A 1 171 ? 4.620   6.581   17.646  1.00 35.86  ? 171 VAL A O    1 
ATOM   2545 C CB   . VAL A 1 171 ? 2.354   4.281   16.492  1.00 39.30  ? 171 VAL A CB   1 
ATOM   2546 C CG1  . VAL A 1 171 ? 2.228   3.003   15.660  1.00 45.55  ? 171 VAL A CG1  1 
ATOM   2547 C CG2  . VAL A 1 171 ? 2.388   3.956   17.977  1.00 40.07  ? 171 VAL A CG2  1 
ATOM   2548 H H    . VAL A 1 171 ? 4.750   3.720   16.948  1.00 54.01  ? 171 VAL A H    1 
ATOM   2549 H HA   . VAL A 1 171 ? 3.530   5.256   15.128  1.00 46.27  ? 171 VAL A HA   1 
ATOM   2550 H HB   . VAL A 1 171 ? 1.572   4.830   16.326  1.00 47.21  ? 171 VAL A HB   1 
ATOM   2551 H HG11 . VAL A 1 171 ? 1.424   2.531   15.927  1.00 54.71  ? 171 VAL A HG11 1 
ATOM   2552 H HG12 . VAL A 1 171 ? 2.175   3.242   14.721  1.00 54.71  ? 171 VAL A HG12 1 
ATOM   2553 H HG13 . VAL A 1 171 ? 3.006   2.446   15.816  1.00 54.71  ? 171 VAL A HG13 1 
ATOM   2554 H HG21 . VAL A 1 171 ? 1.629   3.393   18.194  1.00 48.14  ? 171 VAL A HG21 1 
ATOM   2555 H HG22 . VAL A 1 171 ? 3.214   3.490   18.179  1.00 48.14  ? 171 VAL A HG22 1 
ATOM   2556 H HG23 . VAL A 1 171 ? 2.342   4.783   18.482  1.00 48.14  ? 171 VAL A HG23 1 
ATOM   2557 N N    . HIS A 1 172 ? 2.791   7.309   16.567  1.00 36.43  ? 172 HIS A N    1 
ATOM   2558 C CA   . HIS A 1 172 ? 2.904   8.673   17.054  1.00 36.42  ? 172 HIS A CA   1 
ATOM   2559 C C    . HIS A 1 172 ? 1.672   9.081   17.842  1.00 29.56  ? 172 HIS A C    1 
ATOM   2560 O O    . HIS A 1 172 ? 0.560   8.616   17.583  1.00 39.98  ? 172 HIS A O    1 
ATOM   2561 C CB   . HIS A 1 172 ? 3.132   9.625   15.883  1.00 36.83  ? 172 HIS A CB   1 
ATOM   2562 C CG   . HIS A 1 172 ? 4.297   9.231   15.033  1.00 39.30  ? 172 HIS A CG   1 
ATOM   2563 N ND1  . HIS A 1 172 ? 4.157   8.574   13.829  1.00 38.66  ? 172 HIS A ND1  1 
ATOM   2564 C CD2  . HIS A 1 172 ? 5.628   9.362   15.239  1.00 32.85  ? 172 HIS A CD2  1 
ATOM   2565 C CE1  . HIS A 1 172 ? 5.352   8.339   13.319  1.00 41.76  ? 172 HIS A CE1  1 
ATOM   2566 N NE2  . HIS A 1 172 ? 6.262   8.807   14.154  1.00 37.46  ? 172 HIS A NE2  1 
ATOM   2567 H H    . HIS A 1 172 ? 2.082   7.160   16.105  1.00 43.77  ? 172 HIS A H    1 
ATOM   2568 H HA   . HIS A 1 172 ? 3.652   8.742   17.668  1.00 43.76  ? 172 HIS A HA   1 
ATOM   2569 H HB2  . HIS A 1 172 ? 2.340   9.630   15.322  1.00 44.25  ? 172 HIS A HB2  1 
ATOM   2570 H HB3  . HIS A 1 172 ? 3.300   10.516  16.228  1.00 44.25  ? 172 HIS A HB3  1 
ATOM   2571 H HD2  . HIS A 1 172 ? 6.037   9.754   15.976  1.00 39.47  ? 172 HIS A HD2  1 
ATOM   2572 H HE1  . HIS A 1 172 ? 5.524   7.915   12.509  1.00 50.17  ? 172 HIS A HE1  1 
ATOM   2573 H HE2  . HIS A 1 172 ? 7.113   8.771   14.038  1.00 45.01  ? 172 HIS A HE2  1 
ATOM   2574 N N    . ALA A 1 173 ? 1.893   9.946   18.823  1.00 35.91  ? 173 ALA A N    1 
ATOM   2575 C CA   . ALA A 1 173 ? 0.837   10.423  19.696  1.00 32.85  ? 173 ALA A CA   1 
ATOM   2576 C C    . ALA A 1 173 ? 0.889   11.940  19.736  1.00 30.55  ? 173 ALA A C    1 
ATOM   2577 O O    . ALA A 1 173 ? 1.939   12.551  19.529  1.00 30.87  ? 173 ALA A O    1 
ATOM   2578 C CB   . ALA A 1 173 ? 0.972   9.844   21.107  1.00 36.49  ? 173 ALA A CB   1 
ATOM   2579 H H    . ALA A 1 173 ? 2.666   10.277  19.006  1.00 43.15  ? 173 ALA A H    1 
ATOM   2580 H HA   . ALA A 1 173 ? -0.031  10.155  19.355  1.00 39.48  ? 173 ALA A HA   1 
ATOM   2581 H HB1  . ALA A 1 173 ? 0.245   10.177  21.656  1.00 43.85  ? 173 ALA A HB1  1 
ATOM   2582 H HB2  . ALA A 1 173 ? 0.933   8.876   21.057  1.00 43.85  ? 173 ALA A HB2  1 
ATOM   2583 H HB3  . ALA A 1 173 ? 1.823   10.121  21.482  1.00 43.85  ? 173 ALA A HB3  1 
ATOM   2584 N N    . GLY A 1 174 ? -0.260  12.543  19.984  1.00 31.68  ? 174 GLY A N    1 
ATOM   2585 C CA   . GLY A 1 174 ? -0.330  13.984  20.002  1.00 32.71  ? 174 GLY A CA   1 
ATOM   2586 C C    . GLY A 1 174 ? -1.609  14.432  20.666  1.00 30.13  ? 174 GLY A C    1 
ATOM   2587 O O    . GLY A 1 174 ? -2.360  13.631  21.230  1.00 31.54  ? 174 GLY A O    1 
ATOM   2588 H H    . GLY A 1 174 ? -1.004  12.142  20.144  1.00 38.07  ? 174 GLY A H    1 
ATOM   2589 H HA2  . GLY A 1 174 ? 0.424   14.345  20.495  1.00 39.31  ? 174 GLY A HA2  1 
ATOM   2590 H HA3  . GLY A 1 174 ? -0.309  14.327  19.095  1.00 39.31  ? 174 GLY A HA3  1 
ATOM   2591 N N    . THR A 1 175 ? -1.856  15.730  20.580  1.00 30.33  ? 175 THR A N    1 
ATOM   2592 C CA   . THR A 1 175 ? -3.004  16.348  21.222  1.00 28.61  ? 175 THR A CA   1 
ATOM   2593 C C    . THR A 1 175 ? -3.936  16.931  20.166  1.00 33.71  ? 175 THR A C    1 
ATOM   2594 O O    . THR A 1 175 ? -3.583  17.074  18.991  1.00 39.99  ? 175 THR A O    1 
ATOM   2595 C CB   . THR A 1 175 ? -2.572  17.465  22.188  1.00 36.37  ? 175 THR A CB   1 
ATOM   2596 O OG1  . THR A 1 175 ? -2.000  18.542  21.428  1.00 34.13  ? 175 THR A OG1  1 
ATOM   2597 C CG2  . THR A 1 175 ? -1.567  16.948  23.214  1.00 36.45  ? 175 THR A CG2  1 
ATOM   2598 H H    . THR A 1 175 ? -1.362  16.285  20.147  1.00 36.46  ? 175 THR A H    1 
ATOM   2599 H HA   . THR A 1 175 ? -3.481  15.668  21.723  1.00 34.38  ? 175 THR A HA   1 
ATOM   2600 H HB   . THR A 1 175 ? -3.341  17.789  22.682  1.00 43.70  ? 175 THR A HB   1 
ATOM   2601 H HG1  . THR A 1 175 ? -1.328  18.269  21.005  1.00 41.01  ? 175 THR A HG1  1 
ATOM   2602 H HG21 . THR A 1 175 ? -1.142  17.694  23.666  1.00 43.80  ? 175 THR A HG21 1 
ATOM   2603 H HG22 . THR A 1 175 ? -2.019  16.397  23.872  1.00 43.80  ? 175 THR A HG22 1 
ATOM   2604 H HG23 . THR A 1 175 ? -0.885  16.418  22.772  1.00 43.80  ? 175 THR A HG23 1 
ATOM   2605 N N    . ASP A 1 176 ? -5.149  17.260  20.599  1.00 32.78  ? 176 ASP A N    1 
ATOM   2606 C CA   . ASP A 1 176 ? -5.992  18.190  19.859  1.00 31.65  ? 176 ASP A CA   1 
ATOM   2607 C C    . ASP A 1 176 ? -5.428  19.595  20.061  1.00 29.03  ? 176 ASP A C    1 
ATOM   2608 O O    . ASP A 1 176 ? -4.424  19.789  20.753  1.00 36.60  ? 176 ASP A O    1 
ATOM   2609 C CB   . ASP A 1 176 ? -7.452  18.019  20.279  1.00 35.14  ? 176 ASP A CB   1 
ATOM   2610 C CG   . ASP A 1 176 ? -7.737  18.519  21.680  1.00 39.84  ? 176 ASP A CG   1 
ATOM   2611 O OD1  . ASP A 1 176 ? -6.852  19.132  22.315  1.00 42.80  ? 176 ASP A OD1  1 
ATOM   2612 O OD2  . ASP A 1 176 ? -8.862  18.277  22.164  1.00 44.18  ? 176 ASP A OD2  1 
ATOM   2613 H H    . ASP A 1 176 ? -5.507  16.957  21.320  1.00 39.39  ? 176 ASP A H    1 
ATOM   2614 H HA   . ASP A 1 176 ? -5.982  18.009  18.906  1.00 38.03  ? 176 ASP A HA   1 
ATOM   2615 H HB2  . ASP A 1 176 ? -8.015  18.517  19.666  1.00 42.23  ? 176 ASP A HB2  1 
ATOM   2616 H HB3  . ASP A 1 176 ? -7.680  17.077  20.248  1.00 42.23  ? 176 ASP A HB3  1 
ATOM   2617 N N    . LEU A 1 177 ? -6.040  20.593  19.436  1.00 38.73  ? 177 LEU A N    1 
ATOM   2618 C CA   . LEU A 1 177 ? -5.463  21.932  19.513  1.00 37.89  ? 177 LEU A CA   1 
ATOM   2619 C C    . LEU A 1 177 ? -5.797  22.650  20.815  1.00 44.66  ? 177 LEU A C    1 
ATOM   2620 O O    . LEU A 1 177 ? -5.329  23.775  21.019  1.00 40.38  ? 177 LEU A O    1 
ATOM   2621 C CB   . LEU A 1 177 ? -5.908  22.773  18.318  1.00 37.75  ? 177 LEU A CB   1 
ATOM   2622 C CG   . LEU A 1 177 ? -4.889  22.811  17.175  1.00 43.08  ? 177 LEU A CG   1 
ATOM   2623 C CD1  . LEU A 1 177 ? -3.563  23.428  17.607  1.00 39.20  ? 177 LEU A CD1  1 
ATOM   2624 C CD2  . LEU A 1 177 ? -4.660  21.402  16.629  1.00 37.37  ? 177 LEU A CD2  1 
ATOM   2625 H H    . LEU A 1 177 ? -6.764  20.524  18.976  1.00 46.53  ? 177 LEU A H    1 
ATOM   2626 H HA   . LEU A 1 177 ? -4.497  21.852  19.465  1.00 45.53  ? 177 LEU A HA   1 
ATOM   2627 H HB2  . LEU A 1 177 ? -6.733  22.404  17.968  1.00 45.36  ? 177 LEU A HB2  1 
ATOM   2628 H HB3  . LEU A 1 177 ? -6.052  23.685  18.617  1.00 45.36  ? 177 LEU A HB3  1 
ATOM   2629 H HG   . LEU A 1 177 ? -5.249  23.372  16.470  1.00 51.75  ? 177 LEU A HG   1 
ATOM   2630 H HD11 . LEU A 1 177 ? -3.083  23.729  16.819  1.00 47.10  ? 177 LEU A HD11 1 
ATOM   2631 H HD12 . LEU A 1 177 ? -3.741  24.181  18.193  1.00 47.10  ? 177 LEU A HD12 1 
ATOM   2632 H HD13 . LEU A 1 177 ? -3.041  22.759  18.077  1.00 47.10  ? 177 LEU A HD13 1 
ATOM   2633 H HD21 . LEU A 1 177 ? -4.078  21.454  15.855  1.00 44.90  ? 177 LEU A HD21 1 
ATOM   2634 H HD22 . LEU A 1 177 ? -4.246  20.860  17.318  1.00 44.90  ? 177 LEU A HD22 1 
ATOM   2635 H HD23 . LEU A 1 177 ? -5.514  21.019  16.375  1.00 44.90  ? 177 LEU A HD23 1 
ATOM   2636 N N    . GLU A 1 178 ? -6.583  22.039  21.696  1.00 44.28  ? 178 GLU A N    1 
ATOM   2637 C CA   . GLU A 1 178 ? -6.752  22.548  23.050  1.00 42.59  ? 178 GLU A CA   1 
ATOM   2638 C C    . GLU A 1 178 ? -5.754  21.927  24.018  1.00 34.78  ? 178 GLU A C    1 
ATOM   2639 O O    . GLU A 1 178 ? -5.797  22.230  25.215  1.00 42.57  ? 178 GLU A O    1 
ATOM   2640 C CB   . GLU A 1 178 ? -8.176  22.297  23.550  1.00 42.49  ? 178 GLU A CB   1 
ATOM   2641 C CG   . GLU A 1 178 ? -9.268  22.730  22.581  1.00 46.84  ? 178 GLU A CG   1 
ATOM   2642 C CD   . GLU A 1 178 ? -9.495  24.230  22.573  1.00 56.79  ? 178 GLU A CD   1 
ATOM   2643 O OE1  . GLU A 1 178 ? -8.670  24.966  23.159  1.00 45.23  ? 178 GLU A OE1  1 
ATOM   2644 O OE2  . GLU A 1 178 ? -10.498 24.678  21.977  1.00 70.99  ? 178 GLU A OE2  1 
ATOM   2645 H H    . GLU A 1 178 ? -7.032  21.324  21.531  1.00 53.19  ? 178 GLU A H    1 
ATOM   2646 H HA   . GLU A 1 178 ? -6.620  23.509  23.041  1.00 51.17  ? 178 GLU A HA   1 
ATOM   2647 H HB2  . GLU A 1 178 ? -8.285  21.346  23.709  1.00 51.05  ? 178 GLU A HB2  1 
ATOM   2648 H HB3  . GLU A 1 178 ? -8.305  22.788  24.376  1.00 51.05  ? 178 GLU A HB3  1 
ATOM   2649 H HG2  . GLU A 1 178 ? -9.018  22.460  21.684  1.00 56.27  ? 178 GLU A HG2  1 
ATOM   2650 H HG3  . GLU A 1 178 ? -10.102 22.303  22.835  1.00 56.27  ? 178 GLU A HG3  1 
ATOM   2651 N N    . GLY A 1 179 ? -4.873  21.061  23.527  1.00 33.58  ? 179 GLY A N    1 
ATOM   2652 C CA   . GLY A 1 179 ? -3.792  20.524  24.322  1.00 40.23  ? 179 GLY A CA   1 
ATOM   2653 C C    . GLY A 1 179 ? -4.078  19.215  25.013  1.00 38.82  ? 179 GLY A C    1 
ATOM   2654 O O    . GLY A 1 179 ? -3.254  18.769  25.816  1.00 36.20  ? 179 GLY A O    1 
ATOM   2655 H H    . GLY A 1 179 ? -4.886  20.767  22.719  1.00 40.36  ? 179 GLY A H    1 
ATOM   2656 H HA2  . GLY A 1 179 ? -3.024  20.389  23.746  1.00 48.33  ? 179 GLY A HA2  1 
ATOM   2657 H HA3  . GLY A 1 179 ? -3.563  21.172  25.007  1.00 48.33  ? 179 GLY A HA3  1 
ATOM   2658 N N    . ASN A 1 180 ? -5.209  18.585  24.738  1.00 33.93  ? 180 ASN A N    1 
ATOM   2659 C CA   . ASN A 1 180 ? -5.583  17.341  25.391  1.00 32.74  ? 180 ASN A CA   1 
ATOM   2660 C C    . ASN A 1 180 ? -5.160  16.173  24.511  1.00 36.32  ? 180 ASN A C    1 
ATOM   2661 O O    . ASN A 1 180 ? -5.561  16.086  23.345  1.00 35.08  ? 180 ASN A O    1 
ATOM   2662 C CB   . ASN A 1 180 ? -7.082  17.326  25.672  1.00 36.11  ? 180 ASN A CB   1 
ATOM   2663 C CG   . ASN A 1 180 ? -7.522  18.525  26.490  1.00 38.41  ? 180 ASN A CG   1 
ATOM   2664 O OD1  . ASN A 1 180 ? -7.245  18.604  27.689  1.00 42.20  ? 180 ASN A OD1  1 
ATOM   2665 N ND2  . ASN A 1 180 ? -8.196  19.472  25.847  1.00 41.02  ? 180 ASN A ND2  1 
ATOM   2666 H H    . ASN A 1 180 ? -5.787  18.864  24.165  1.00 40.78  ? 180 ASN A H    1 
ATOM   2667 H HA   . ASN A 1 180 ? -5.118  17.250  26.237  1.00 39.34  ? 180 ASN A HA   1 
ATOM   2668 H HB2  . ASN A 1 180 ? -7.564  17.340  24.831  1.00 43.39  ? 180 ASN A HB2  1 
ATOM   2669 H HB3  . ASN A 1 180 ? -7.305  16.523  26.169  1.00 43.39  ? 180 ASN A HB3  1 
ATOM   2670 H HD21 . ASN A 1 180 ? -8.466  20.171  26.270  1.00 49.29  ? 180 ASN A HD21 1 
ATOM   2671 H HD22 . ASN A 1 180 ? -8.362  19.387  25.008  1.00 49.29  ? 180 ASN A HD22 1 
ATOM   2672 N N    . PHE A 1 181 ? -4.334  15.291  25.068  1.00 32.70  ? 181 PHE A N    1 
ATOM   2673 C CA   . PHE A 1 181 ? -3.797  14.189  24.291  1.00 31.82  ? 181 PHE A CA   1 
ATOM   2674 C C    . PHE A 1 181 ? -4.922  13.333  23.725  1.00 37.69  ? 181 PHE A C    1 
ATOM   2675 O O    . PHE A 1 181 ? -5.990  13.180  24.325  1.00 33.33  ? 181 PHE A O    1 
ATOM   2676 C CB   . PHE A 1 181 ? -2.871  13.321  25.151  1.00 35.81  ? 181 PHE A CB   1 
ATOM   2677 C CG   . PHE A 1 181 ? -1.408  13.499  24.843  1.00 45.01  ? 181 PHE A CG   1 
ATOM   2678 C CD1  . PHE A 1 181 ? -0.658  14.461  25.496  1.00 39.45  ? 181 PHE A CD1  1 
ATOM   2679 C CD2  . PHE A 1 181 ? -0.788  12.706  23.891  1.00 38.18  ? 181 PHE A CD2  1 
ATOM   2680 C CE1  . PHE A 1 181 ? 0.688   14.630  25.207  1.00 34.91  ? 181 PHE A CE1  1 
ATOM   2681 C CE2  . PHE A 1 181 ? 0.553   12.867  23.597  1.00 37.75  ? 181 PHE A CE2  1 
ATOM   2682 C CZ   . PHE A 1 181 ? 1.293   13.831  24.255  1.00 41.38  ? 181 PHE A CZ   1 
ATOM   2683 H H    . PHE A 1 181 ? -4.074  15.312  25.888  1.00 39.30  ? 181 PHE A H    1 
ATOM   2684 H HA   . PHE A 1 181 ? -3.278  14.546  23.553  1.00 38.24  ? 181 PHE A HA   1 
ATOM   2685 H HB2  . PHE A 1 181 ? -3.007  13.551  26.084  1.00 43.03  ? 181 PHE A HB2  1 
ATOM   2686 H HB3  . PHE A 1 181 ? -3.093  12.388  25.003  1.00 43.03  ? 181 PHE A HB3  1 
ATOM   2687 H HD1  . PHE A 1 181 ? -1.061  15.001  26.137  1.00 47.39  ? 181 PHE A HD1  1 
ATOM   2688 H HD2  . PHE A 1 181 ? -1.281  12.056  23.444  1.00 45.87  ? 181 PHE A HD2  1 
ATOM   2689 H HE1  . PHE A 1 181 ? 1.183   15.279  25.653  1.00 41.95  ? 181 PHE A HE1  1 
ATOM   2690 H HE2  . PHE A 1 181 ? 0.957   12.328  22.956  1.00 45.36  ? 181 PHE A HE2  1 
ATOM   2691 H HZ   . PHE A 1 181 ? 2.195   13.941  24.058  1.00 49.71  ? 181 PHE A HZ   1 
ATOM   2692 N N    . TYR A 1 182 ? -4.679  12.793  22.535  1.00 32.62  ? 182 TYR A N    1 
ATOM   2693 C CA   . TYR A 1 182 ? -5.462  11.671  22.040  1.00 34.63  ? 182 TYR A CA   1 
ATOM   2694 C C    . TYR A 1 182 ? -4.924  10.404  22.694  1.00 29.53  ? 182 TYR A C    1 
ATOM   2695 O O    . TYR A 1 182 ? -3.748  10.065  22.519  1.00 35.78  ? 182 TYR A O    1 
ATOM   2696 C CB   . TYR A 1 182 ? -5.369  11.571  20.524  1.00 37.48  ? 182 TYR A CB   1 
ATOM   2697 C CG   . TYR A 1 182 ? -6.169  12.609  19.771  1.00 32.15  ? 182 TYR A CG   1 
ATOM   2698 C CD1  . TYR A 1 182 ? -7.532  12.441  19.552  1.00 37.09  ? 182 TYR A CD1  1 
ATOM   2699 C CD2  . TYR A 1 182 ? -5.559  13.747  19.264  1.00 37.51  ? 182 TYR A CD2  1 
ATOM   2700 C CE1  . TYR A 1 182 ? -8.262  13.382  18.856  1.00 32.58  ? 182 TYR A CE1  1 
ATOM   2701 C CE2  . TYR A 1 182 ? -6.282  14.691  18.568  1.00 34.01  ? 182 TYR A CE2  1 
ATOM   2702 C CZ   . TYR A 1 182 ? -7.631  14.504  18.367  1.00 34.26  ? 182 TYR A CZ   1 
ATOM   2703 O OH   . TYR A 1 182 ? -8.355  15.444  17.674  1.00 35.59  ? 182 TYR A OH   1 
ATOM   2704 H H    . TYR A 1 182 ? -4.064  13.060  21.996  1.00 39.20  ? 182 TYR A H    1 
ATOM   2705 H HA   . TYR A 1 182 ? -6.398  11.790  22.267  1.00 41.62  ? 182 TYR A HA   1 
ATOM   2706 H HB2  . TYR A 1 182 ? -4.440  11.674  20.264  1.00 45.03  ? 182 TYR A HB2  1 
ATOM   2707 H HB3  . TYR A 1 182 ? -5.694  10.698  20.252  1.00 45.03  ? 182 TYR A HB3  1 
ATOM   2708 H HD1  . TYR A 1 182 ? -7.957  11.682  19.880  1.00 44.56  ? 182 TYR A HD1  1 
ATOM   2709 H HD2  . TYR A 1 182 ? -4.647  13.874  19.395  1.00 45.07  ? 182 TYR A HD2  1 
ATOM   2710 H HE1  . TYR A 1 182 ? -9.173  13.259  18.717  1.00 39.16  ? 182 TYR A HE1  1 
ATOM   2711 H HE2  . TYR A 1 182 ? -5.860  15.450  18.235  1.00 40.87  ? 182 TYR A HE2  1 
ATOM   2712 H HH   . TYR A 1 182 ? -7.869  16.105  17.494  1.00 42.77  ? 182 TYR A HH   1 
ATOM   2713 N N    . GLY A 1 183 ? -5.762  9.721   23.464  1.00 30.58  ? 183 GLY A N    1 
ATOM   2714 C CA   . GLY A 1 183 ? -5.382  8.455   24.039  1.00 35.04  ? 183 GLY A CA   1 
ATOM   2715 C C    . GLY A 1 183 ? -4.694  8.614   25.375  1.00 32.99  ? 183 GLY A C    1 
ATOM   2716 O O    . GLY A 1 183 ? -4.475  9.727   25.859  1.00 33.89  ? 183 GLY A O    1 
ATOM   2717 H H    . GLY A 1 183 ? -6.558  9.978   23.665  1.00 36.75  ? 183 GLY A H    1 
ATOM   2718 H HA2  . GLY A 1 183 ? -6.174  7.910   24.166  1.00 42.10  ? 183 GLY A HA2  1 
ATOM   2719 H HA3  . GLY A 1 183 ? -4.776  7.997   23.436  1.00 42.10  ? 183 GLY A HA3  1 
ATOM   2720 N N    . PRO A 1 184 ? -4.327  7.490   25.995  1.00 28.79  ? 184 PRO A N    1 
ATOM   2721 C CA   . PRO A 1 184 ? -3.795  7.508   27.362  1.00 34.50  ? 184 PRO A CA   1 
ATOM   2722 C C    . PRO A 1 184 ? -2.287  7.741   27.429  1.00 43.20  ? 184 PRO A C    1 
ATOM   2723 O O    . PRO A 1 184 ? -1.555  7.038   28.139  1.00 46.21  ? 184 PRO A O    1 
ATOM   2724 C CB   . PRO A 1 184 ? -4.163  6.112   27.880  1.00 36.77  ? 184 PRO A CB   1 
ATOM   2725 C CG   . PRO A 1 184 ? -4.054  5.249   26.642  1.00 36.88  ? 184 PRO A CG   1 
ATOM   2726 C CD   . PRO A 1 184 ? -4.480  6.120   25.470  1.00 33.95  ? 184 PRO A CD   1 
ATOM   2727 H HA   . PRO A 1 184 ? -4.248  8.190   27.881  1.00 41.46  ? 184 PRO A HA   1 
ATOM   2728 H HB2  . PRO A 1 184 ? -3.538  5.830   28.565  1.00 44.18  ? 184 PRO A HB2  1 
ATOM   2729 H HB3  . PRO A 1 184 ? -5.066  6.111   28.234  1.00 44.18  ? 184 PRO A HB3  1 
ATOM   2730 H HG2  . PRO A 1 184 ? -3.137  4.953   26.533  1.00 44.32  ? 184 PRO A HG2  1 
ATOM   2731 H HG3  . PRO A 1 184 ? -4.642  4.482   26.729  1.00 44.32  ? 184 PRO A HG3  1 
ATOM   2732 H HD2  . PRO A 1 184 ? -3.901  5.976   24.705  1.00 40.80  ? 184 PRO A HD2  1 
ATOM   2733 H HD3  . PRO A 1 184 ? -5.402  5.944   25.226  1.00 40.80  ? 184 PRO A HD3  1 
ATOM   2734 N N    . PHE A 1 185 ? -1.806  8.739   26.700  1.00 41.58  ? 185 PHE A N    1 
ATOM   2735 C CA   . PHE A 1 185 ? -0.386  9.043   26.627  1.00 40.34  ? 185 PHE A CA   1 
ATOM   2736 C C    . PHE A 1 185 ? -0.100  10.368  27.317  1.00 44.57  ? 185 PHE A C    1 
ATOM   2737 O O    . PHE A 1 185 ? -0.984  11.210  27.490  1.00 43.60  ? 185 PHE A O    1 
ATOM   2738 C CB   . PHE A 1 185 ? 0.074   9.078   25.166  1.00 36.64  ? 185 PHE A CB   1 
ATOM   2739 C CG   . PHE A 1 185 ? -0.415  7.913   24.366  1.00 35.66  ? 185 PHE A CG   1 
ATOM   2740 C CD1  . PHE A 1 185 ? 0.011   6.629   24.662  1.00 39.22  ? 185 PHE A CD1  1 
ATOM   2741 C CD2  . PHE A 1 185 ? -1.316  8.093   23.333  1.00 41.00  ? 185 PHE A CD2  1 
ATOM   2742 C CE1  . PHE A 1 185 ? -0.445  5.551   23.935  1.00 39.97  ? 185 PHE A CE1  1 
ATOM   2743 C CE2  . PHE A 1 185 ? -1.774  7.018   22.603  1.00 36.84  ? 185 PHE A CE2  1 
ATOM   2744 C CZ   . PHE A 1 185 ? -1.339  5.746   22.904  1.00 36.38  ? 185 PHE A CZ   1 
ATOM   2745 H H    . PHE A 1 185 ? -2.295  9.265   26.227  1.00 49.96  ? 185 PHE A H    1 
ATOM   2746 H HA   . PHE A 1 185 ? 0.126   8.359   27.086  1.00 48.46  ? 185 PHE A HA   1 
ATOM   2747 H HB2  . PHE A 1 185 ? -0.261  9.888   24.751  1.00 44.02  ? 185 PHE A HB2  1 
ATOM   2748 H HB3  . PHE A 1 185 ? 1.044   9.071   25.143  1.00 44.02  ? 185 PHE A HB3  1 
ATOM   2749 H HD1  . PHE A 1 185 ? 0.610   6.493   25.360  1.00 47.13  ? 185 PHE A HD1  1 
ATOM   2750 H HD2  . PHE A 1 185 ? -1.616  8.950   23.129  1.00 49.26  ? 185 PHE A HD2  1 
ATOM   2751 H HE1  . PHE A 1 185 ? -0.149  4.693   24.139  1.00 48.03  ? 185 PHE A HE1  1 
ATOM   2752 H HE2  . PHE A 1 185 ? -2.377  7.151   21.908  1.00 44.26  ? 185 PHE A HE2  1 
ATOM   2753 H HZ   . PHE A 1 185 ? -1.648  5.020   22.412  1.00 43.72  ? 185 PHE A HZ   1 
ATOM   2754 N N    . VAL A 1 186 ? 1.152   10.530  27.731  1.00 42.04  ? 186 VAL A N    1 
ATOM   2755 C CA   . VAL A 1 186 ? 1.604   11.722  28.435  1.00 41.40  ? 186 VAL A CA   1 
ATOM   2756 C C    . VAL A 1 186 ? 2.927   12.157  27.826  1.00 39.00  ? 186 VAL A C    1 
ATOM   2757 O O    . VAL A 1 186 ? 3.684   11.335  27.299  1.00 34.06  ? 186 VAL A O    1 
ATOM   2758 C CB   . VAL A 1 186 ? 1.737   11.466  29.951  1.00 39.87  ? 186 VAL A CB   1 
ATOM   2759 C CG1  . VAL A 1 186 ? 0.357   11.448  30.596  1.00 49.34  ? 186 VAL A CG1  1 
ATOM   2760 C CG2  . VAL A 1 186 ? 2.464   10.156  30.222  1.00 41.67  ? 186 VAL A CG2  1 
ATOM   2761 H H    . VAL A 1 186 ? 1.774   9.948   27.612  1.00 50.50  ? 186 VAL A H    1 
ATOM   2762 H HA   . VAL A 1 186 ? 0.968   12.444  28.314  1.00 49.74  ? 186 VAL A HA   1 
ATOM   2763 H HB   . VAL A 1 186 ? 2.260   12.182  30.344  1.00 47.90  ? 186 VAL A HB   1 
ATOM   2764 H HG11 . VAL A 1 186 ? 0.456   11.288  31.547  1.00 59.26  ? 186 VAL A HG11 1 
ATOM   2765 H HG12 . VAL A 1 186 ? -0.072  12.304  30.447  1.00 59.26  ? 186 VAL A HG12 1 
ATOM   2766 H HG13 . VAL A 1 186 ? -0.170  10.739  30.194  1.00 59.26  ? 186 VAL A HG13 1 
ATOM   2767 H HG21 . VAL A 1 186 ? 2.653   10.091  31.172  1.00 50.06  ? 186 VAL A HG21 1 
ATOM   2768 H HG22 . VAL A 1 186 ? 1.898   9.418   29.946  1.00 50.06  ? 186 VAL A HG22 1 
ATOM   2769 H HG23 . VAL A 1 186 ? 3.293   10.145  29.719  1.00 50.06  ? 186 VAL A HG23 1 
ATOM   2770 N N    . ASP A 1 187 ? 3.196   13.465  27.866  1.00 37.47  ? 187 ASP A N    1 
ATOM   2771 C CA   . ASP A 1 187 ? 4.391   13.994  27.203  1.00 41.87  ? 187 ASP A CA   1 
ATOM   2772 C C    . ASP A 1 187 ? 5.584   13.888  28.154  1.00 45.64  ? 187 ASP A C    1 
ATOM   2773 O O    . ASP A 1 187 ? 6.135   14.869  28.658  1.00 40.39  ? 187 ASP A O    1 
ATOM   2774 C CB   . ASP A 1 187 ? 4.162   15.417  26.693  1.00 34.69  ? 187 ASP A CB   1 
ATOM   2775 C CG   . ASP A 1 187 ? 3.573   16.359  27.721  1.00 38.14  ? 187 ASP A CG   1 
ATOM   2776 O OD1  . ASP A 1 187 ? 3.111   15.909  28.785  1.00 38.83  ? 187 ASP A OD1  1 
ATOM   2777 O OD2  . ASP A 1 187 ? 3.575   17.576  27.434  1.00 36.04  ? 187 ASP A OD2  1 
ATOM   2778 H H    . ASP A 1 187 ? 2.711   14.054  28.263  1.00 45.02  ? 187 ASP A H    1 
ATOM   2779 H HA   . ASP A 1 187 ? 4.581   13.448  26.424  1.00 50.30  ? 187 ASP A HA   1 
ATOM   2780 H HB2  . ASP A 1 187 ? 5.014   15.785  26.411  1.00 41.68  ? 187 ASP A HB2  1 
ATOM   2781 H HB3  . ASP A 1 187 ? 3.550   15.382  25.941  1.00 41.68  ? 187 ASP A HB3  1 
ATOM   2782 N N    . ARG A 1 188 ? 5.952   12.631  28.398  1.00 41.55  ? 188 ARG A N    1 
ATOM   2783 C CA   . ARG A 1 188 ? 7.114   12.252  29.185  1.00 48.13  ? 188 ARG A CA   1 
ATOM   2784 C C    . ARG A 1 188 ? 7.829   11.128  28.450  1.00 39.70  ? 188 ARG A C    1 
ATOM   2785 O O    . ARG A 1 188 ? 7.178   10.275  27.840  1.00 42.26  ? 188 ARG A O    1 
ATOM   2786 C CB   . ARG A 1 188 ? 6.742   11.770  30.590  1.00 46.02  ? 188 ARG A CB   1 
ATOM   2787 C CG   . ARG A 1 188 ? 5.594   12.501  31.258  1.00 50.25  ? 188 ARG A CG   1 
ATOM   2788 C CD   . ARG A 1 188 ? 5.131   11.736  32.501  1.00 58.44  ? 188 ARG A CD   1 
ATOM   2789 N NE   . ARG A 1 188 ? 3.882   12.251  33.049  1.00 72.27  ? 188 ARG A NE   1 
ATOM   2790 C CZ   . ARG A 1 188 ? 3.091   11.582  33.878  1.00 71.05  ? 188 ARG A CZ   1 
ATOM   2791 N NH1  . ARG A 1 188 ? 3.386   10.357  34.280  1.00 70.05  ? 188 ARG A NH1  1 
ATOM   2792 N NH2  . ARG A 1 188 ? 1.974   12.158  34.314  1.00 72.82  ? 188 ARG A NH2  1 
ATOM   2793 H H    . ARG A 1 188 ? 5.520   11.949  28.103  1.00 49.92  ? 188 ARG A H    1 
ATOM   2794 H HA   . ARG A 1 188 ? 7.701   13.018  29.283  1.00 57.81  ? 188 ARG A HA   1 
ATOM   2795 H HB2  . ARG A 1 188 ? 6.493   10.834  30.533  1.00 55.29  ? 188 ARG A HB2  1 
ATOM   2796 H HB3  . ARG A 1 188 ? 7.519   11.872  31.162  1.00 55.29  ? 188 ARG A HB3  1 
ATOM   2797 H HG2  . ARG A 1 188 ? 5.883   13.386  31.528  1.00 60.35  ? 188 ARG A HG2  1 
ATOM   2798 H HG3  . ARG A 1 188 ? 4.848   12.570  30.641  1.00 60.35  ? 188 ARG A HG3  1 
ATOM   2799 H HD2  . ARG A 1 188 ? 4.995   10.805  32.267  1.00 70.19  ? 188 ARG A HD2  1 
ATOM   2800 H HD3  . ARG A 1 188 ? 5.812   11.809  33.188  1.00 70.19  ? 188 ARG A HD3  1 
ATOM   2801 H HE   . ARG A 1 188 ? 3.640   13.043  32.818  1.00 86.78  ? 188 ARG A HE   1 
ATOM   2802 H HH11 . ARG A 1 188 ? 4.106   9.976   34.003  1.00 84.12  ? 188 ARG A HH11 1 
ATOM   2803 H HH12 . ARG A 1 188 ? 2.859   9.942   34.818  1.00 84.12  ? 188 ARG A HH12 1 
ATOM   2804 H HH21 . ARG A 1 188 ? 1.772   12.954  34.058  1.00 87.44  ? 188 ARG A HH21 1 
ATOM   2805 H HH22 . ARG A 1 188 ? 1.453   11.735  34.852  1.00 87.44  ? 188 ARG A HH22 1 
ATOM   2806 N N    . GLN A 1 189 ? 9.159   11.108  28.525  1.00 36.90  ? 189 GLN A N    1 
ATOM   2807 C CA   . GLN A 1 189 ? 9.941   10.048  27.888  1.00 41.47  ? 189 GLN A CA   1 
ATOM   2808 C C    . GLN A 1 189 ? 9.992   8.843   28.828  1.00 54.40  ? 189 GLN A C    1 
ATOM   2809 O O    . GLN A 1 189 ? 11.031  8.458   29.369  1.00 57.89  ? 189 GLN A O    1 
ATOM   2810 C CB   . GLN A 1 189 ? 11.324  10.558  27.511  1.00 39.23  ? 189 GLN A CB   1 
ATOM   2811 C CG   . GLN A 1 189 ? 11.268  11.512  26.317  1.00 53.69  ? 189 GLN A CG   1 
ATOM   2812 C CD   . GLN A 1 189 ? 12.619  11.813  25.698  1.00 56.67  ? 189 GLN A CD   1 
ATOM   2813 O OE1  . GLN A 1 189 ? 12.711  12.123  24.511  1.00 46.58  ? 189 GLN A OE1  1 
ATOM   2814 N NE2  . GLN A 1 189 ? 13.673  11.735  26.503  1.00 59.08  ? 189 GLN A NE2  1 
ATOM   2815 H H    . GLN A 1 189 ? 9.631   11.696  28.939  1.00 44.34  ? 189 GLN A H    1 
ATOM   2816 H HA   . GLN A 1 189 ? 9.505   9.768   27.069  1.00 49.82  ? 189 GLN A HA   1 
ATOM   2817 H HB2  . GLN A 1 189 ? 11.706  11.035  28.264  1.00 47.13  ? 189 GLN A HB2  1 
ATOM   2818 H HB3  . GLN A 1 189 ? 11.889  9.806   27.274  1.00 47.13  ? 189 GLN A HB3  1 
ATOM   2819 H HG2  . GLN A 1 189 ? 10.711  11.116  25.628  1.00 64.49  ? 189 GLN A HG2  1 
ATOM   2820 H HG3  . GLN A 1 189 ? 10.885  12.354  26.609  1.00 64.49  ? 189 GLN A HG3  1 
ATOM   2821 H HE21 . GLN A 1 189 ? 13.569  11.523  27.329  1.00 70.95  ? 189 GLN A HE21 1 
ATOM   2822 H HE22 . GLN A 1 189 ? 14.461  11.897  26.196  1.00 70.95  ? 189 GLN A HE22 1 
ATOM   2823 N N    . THR A 1 190 ? 8.819   8.247   29.013  1.00 54.61  ? 190 THR A N    1 
ATOM   2824 C CA   . THR A 1 190 ? 8.632   7.044   29.806  1.00 48.10  ? 190 THR A CA   1 
ATOM   2825 C C    . THR A 1 190 ? 8.270   5.879   28.896  1.00 52.10  ? 190 THR A C    1 
ATOM   2826 O O    . THR A 1 190 ? 8.016   6.042   27.699  1.00 51.10  ? 190 THR A O    1 
ATOM   2827 C CB   . THR A 1 190 ? 7.528   7.249   30.849  1.00 51.59  ? 190 THR A CB   1 
ATOM   2828 O OG1  . THR A 1 190 ? 6.429   7.939   30.242  1.00 52.17  ? 190 THR A OG1  1 
ATOM   2829 C CG2  . THR A 1 190 ? 8.048   8.055   32.023  1.00 50.32  ? 190 THR A CG2  1 
ATOM   2830 H H    . THR A 1 190 ? 8.085   8.537   28.672  1.00 65.59  ? 190 THR A H    1 
ATOM   2831 H HA   . THR A 1 190 ? 9.459   6.836   30.268  1.00 57.78  ? 190 THR A HA   1 
ATOM   2832 H HB   . THR A 1 190 ? 7.229   6.389   31.183  1.00 61.96  ? 190 THR A HB   1 
ATOM   2833 H HG1  . THR A 1 190 ? 5.825   8.072   30.811  1.00 62.66  ? 190 THR A HG1  1 
ATOM   2834 H HG21 . THR A 1 190 ? 7.342   8.181   32.677  1.00 60.45  ? 190 THR A HG21 1 
ATOM   2835 H HG22 . THR A 1 190 ? 8.788   7.590   32.443  1.00 60.45  ? 190 THR A HG22 1 
ATOM   2836 H HG23 . THR A 1 190 ? 8.353   8.924   31.719  1.00 60.45  ? 190 THR A HG23 1 
ATOM   2837 N N    . ALA A 1 191 ? 8.243   4.688   29.487  1.00 51.57  ? 191 ALA A N    1 
ATOM   2838 C CA   . ALA A 1 191 ? 7.785   3.492   28.791  1.00 51.41  ? 191 ALA A CA   1 
ATOM   2839 C C    . ALA A 1 191 ? 6.264   3.538   28.713  1.00 62.68  ? 191 ALA A C    1 
ATOM   2840 O O    . ALA A 1 191 ? 5.578   3.386   29.729  1.00 52.27  ? 191 ALA A O    1 
ATOM   2841 C CB   . ALA A 1 191 ? 8.263   2.235   29.512  1.00 63.00  ? 191 ALA A CB   1 
ATOM   2842 H H    . ALA A 1 191 ? 8.488   4.546   30.300  1.00 61.94  ? 191 ALA A H    1 
ATOM   2843 H HA   . ALA A 1 191 ? 8.147   3.476   27.891  1.00 61.74  ? 191 ALA A HA   1 
ATOM   2844 H HB1  . ALA A 1 191 ? 7.951   1.455   29.027  1.00 75.65  ? 191 ALA A HB1  1 
ATOM   2845 H HB2  . ALA A 1 191 ? 9.232   2.239   29.544  1.00 75.65  ? 191 ALA A HB2  1 
ATOM   2846 H HB3  . ALA A 1 191 ? 7.902   2.231   30.412  1.00 75.65  ? 191 ALA A HB3  1 
ATOM   2847 N N    . GLN A 1 192 ? 5.736   3.766   27.513  1.00 46.92  ? 192 GLN A N    1 
ATOM   2848 C CA   . GLN A 1 192 ? 4.301   3.802   27.275  1.00 41.22  ? 192 GLN A CA   1 
ATOM   2849 C C    . GLN A 1 192 ? 3.969   2.887   26.108  1.00 48.00  ? 192 GLN A C    1 
ATOM   2850 O O    . GLN A 1 192 ? 4.761   2.732   25.175  1.00 45.27  ? 192 GLN A O    1 
ATOM   2851 C CB   . GLN A 1 192 ? 3.804   5.221   26.972  1.00 40.05  ? 192 GLN A CB   1 
ATOM   2852 C CG   . GLN A 1 192 ? 4.144   6.228   28.057  1.00 42.07  ? 192 GLN A CG   1 
ATOM   2853 C CD   . GLN A 1 192 ? 3.705   7.639   27.713  1.00 40.22  ? 192 GLN A CD   1 
ATOM   2854 O OE1  . GLN A 1 192 ? 2.521   7.909   27.519  1.00 39.85  ? 192 GLN A OE1  1 
ATOM   2855 N NE2  . GLN A 1 192 ? 4.666   8.553   27.657  1.00 42.34  ? 192 GLN A NE2  1 
ATOM   2856 H H    . GLN A 1 192 ? 6.203   3.906   26.805  1.00 56.36  ? 192 GLN A H    1 
ATOM   2857 H HA   . GLN A 1 192 ? 3.834   3.486   28.065  1.00 49.53  ? 192 GLN A HA   1 
ATOM   2858 H HB2  . GLN A 1 192 ? 4.213   5.526   26.147  1.00 48.11  ? 192 GLN A HB2  1 
ATOM   2859 H HB3  . GLN A 1 192 ? 2.839   5.201   26.878  1.00 48.11  ? 192 GLN A HB3  1 
ATOM   2860 H HG2  . GLN A 1 192 ? 3.698   5.968   28.878  1.00 50.55  ? 192 GLN A HG2  1 
ATOM   2861 H HG3  . GLN A 1 192 ? 5.104   6.237   28.189  1.00 50.55  ? 192 GLN A HG3  1 
ATOM   2862 H HE21 . GLN A 1 192 ? 5.482   8.330   27.811  1.00 50.87  ? 192 GLN A HE21 1 
ATOM   2863 H HE22 . GLN A 1 192 ? 4.473   9.369   27.466  1.00 50.87  ? 192 GLN A HE22 1 
ATOM   2864 N N    . ALA A 1 193 ? 2.787   2.288   26.164  1.00 47.86  ? 193 ALA A N    1 
ATOM   2865 C CA   . ALA A 1 193 ? 2.336   1.377   25.127  1.00 59.56  ? 193 ALA A CA   1 
ATOM   2866 C C    . ALA A 1 193 ? 0.883   1.675   24.801  1.00 50.71  ? 193 ALA A C    1 
ATOM   2867 O O    . ALA A 1 193 ? 0.063   1.880   25.700  1.00 41.37  ? 193 ALA A O    1 
ATOM   2868 C CB   . ALA A 1 193 ? 2.499   -0.085  25.560  1.00 54.56  ? 193 ALA A CB   1 
ATOM   2869 H H    . ALA A 1 193 ? 2.221   2.395   26.803  1.00 57.49  ? 193 ALA A H    1 
ATOM   2870 H HA   . ALA A 1 193 ? 2.858   1.510   24.321  1.00 71.53  ? 193 ALA A HA   1 
ATOM   2871 H HB1  . ALA A 1 193 ? 2.185   -0.662  24.847  1.00 65.53  ? 193 ALA A HB1  1 
ATOM   2872 H HB2  . ALA A 1 193 ? 3.436   -0.259  25.738  1.00 65.53  ? 193 ALA A HB2  1 
ATOM   2873 H HB3  . ALA A 1 193 ? 1.976   -0.237  26.363  1.00 65.53  ? 193 ALA A HB3  1 
ATOM   2874 N N    . ALA A 1 194 ? 0.578   1.724   23.510  1.00 56.19  ? 194 ALA A N    1 
ATOM   2875 C CA   . ALA A 1 194 ? -0.800  1.853   23.070  1.00 48.15  ? 194 ALA A CA   1 
ATOM   2876 C C    . ALA A 1 194 ? -1.521  0.523   23.244  1.00 45.34  ? 194 ALA A C    1 
ATOM   2877 O O    . ALA A 1 194 ? -0.924  -0.551  23.124  1.00 58.15  ? 194 ALA A O    1 
ATOM   2878 C CB   . ALA A 1 194 ? -0.859  2.297   21.608  1.00 52.07  ? 194 ALA A CB   1 
ATOM   2879 H H    . ALA A 1 194 ? 1.152   1.684   22.871  1.00 67.49  ? 194 ALA A H    1 
ATOM   2880 H HA   . ALA A 1 194 ? -1.256  2.526   23.600  1.00 57.84  ? 194 ALA A HA   1 
ATOM   2881 H HB1  . ALA A 1 194 ? -1.788  2.372   21.338  1.00 62.54  ? 194 ALA A HB1  1 
ATOM   2882 H HB2  . ALA A 1 194 ? -0.419  3.157   21.521  1.00 62.54  ? 194 ALA A HB2  1 
ATOM   2883 H HB3  . ALA A 1 194 ? -0.408  1.637   21.059  1.00 62.54  ? 194 ALA A HB3  1 
ATOM   2884 N N    . GLY A 1 195 ? -2.813  0.601   23.547  1.00 47.20  ? 195 GLY A N    1 
ATOM   2885 C CA   . GLY A 1 195 ? -3.627  -0.597  23.567  1.00 54.18  ? 195 GLY A CA   1 
ATOM   2886 C C    . GLY A 1 195 ? -3.638  -1.291  22.219  1.00 53.82  ? 195 GLY A C    1 
ATOM   2887 O O    . GLY A 1 195 ? -3.260  -0.725  21.194  1.00 50.41  ? 195 GLY A O    1 
ATOM   2888 H H    . GLY A 1 195 ? -3.232  1.326   23.742  1.00 56.70  ? 195 GLY A H    1 
ATOM   2889 H HA2  . GLY A 1 195 ? -3.278  -1.215  24.229  1.00 65.07  ? 195 GLY A HA2  1 
ATOM   2890 H HA3  . GLY A 1 195 ? -4.539  -0.365  23.802  1.00 65.07  ? 195 GLY A HA3  1 
ATOM   2891 N N    . THR A 1 196 ? -4.076  -2.547  22.225  1.00 50.48  ? 196 THR A N    1 
ATOM   2892 C CA   . THR A 1 196 ? -4.136  -3.315  20.987  1.00 58.08  ? 196 THR A CA   1 
ATOM   2893 C C    . THR A 1 196 ? -5.040  -2.618  19.978  1.00 49.61  ? 196 THR A C    1 
ATOM   2894 O O    . THR A 1 196 ? -6.151  -2.193  20.310  1.00 51.30  ? 196 THR A O    1 
ATOM   2895 C CB   . THR A 1 196 ? -4.642  -4.732  21.263  1.00 56.40  ? 196 THR A CB   1 
ATOM   2896 O OG1  . THR A 1 196 ? -3.802  -5.361  22.240  1.00 57.38  ? 196 THR A OG1  1 
ATOM   2897 C CG2  . THR A 1 196 ? -4.645  -5.564  19.981  1.00 51.99  ? 196 THR A CG2  1 
ATOM   2898 H H    . THR A 1 196 ? -4.342  -2.972  22.924  1.00 60.64  ? 196 THR A H    1 
ATOM   2899 H HA   . THR A 1 196 ? -3.245  -3.384  20.609  1.00 69.75  ? 196 THR A HA   1 
ATOM   2900 H HB   . THR A 1 196 ? -5.551  -4.690  21.599  1.00 67.73  ? 196 THR A HB   1 
ATOM   2901 H HG1  . THR A 1 196 ? -4.071  -6.142  22.390  1.00 68.91  ? 196 THR A HG1  1 
ATOM   2902 H HG21 . THR A 1 196 ? -4.815  -6.496  20.191  1.00 62.45  ? 196 THR A HG21 1 
ATOM   2903 H HG22 . THR A 1 196 ? -5.337  -5.246  19.381  1.00 62.45  ? 196 THR A HG22 1 
ATOM   2904 H HG23 . THR A 1 196 ? -3.786  -5.493  19.537  1.00 62.45  ? 196 THR A HG23 1 
ATOM   2905 N N    . ASP A 1 197 ? -4.559  -2.500  18.743  1.00 47.40  ? 197 ASP A N    1 
ATOM   2906 C CA   . ASP A 1 197 ? -5.317  -1.832  17.698  1.00 48.31  ? 197 ASP A CA   1 
ATOM   2907 C C    . ASP A 1 197 ? -6.332  -2.789  17.075  1.00 56.42  ? 197 ASP A C    1 
ATOM   2908 O O    . ASP A 1 197 ? -6.262  -4.012  17.235  1.00 48.64  ? 197 ASP A O    1 
ATOM   2909 C CB   . ASP A 1 197 ? -4.379  -1.295  16.615  1.00 47.82  ? 197 ASP A CB   1 
ATOM   2910 C CG   . ASP A 1 197 ? -4.926  -0.053  15.920  1.00 42.50  ? 197 ASP A CG   1 
ATOM   2911 O OD1  . ASP A 1 197 ? -5.813  0.620   16.489  1.00 48.62  ? 197 ASP A OD1  1 
ATOM   2912 O OD2  . ASP A 1 197 ? -4.456  0.260   14.805  1.00 53.79  ? 197 ASP A OD2  1 
ATOM   2913 H H    . ASP A 1 197 ? -3.795  -2.800  18.487  1.00 56.94  ? 197 ASP A H    1 
ATOM   2914 H HA   . ASP A 1 197 ? -5.800  -1.084  18.082  1.00 58.03  ? 197 ASP A HA   1 
ATOM   2915 H HB2  . ASP A 1 197 ? -3.530  -1.062  17.021  1.00 57.44  ? 197 ASP A HB2  1 
ATOM   2916 H HB3  . ASP A 1 197 ? -4.248  -1.982  15.942  1.00 57.44  ? 197 ASP A HB3  1 
ATOM   2917 N N    . THR A 1 198 ? -7.290  -2.205  16.359  1.00 51.53  ? 198 THR A N    1 
ATOM   2918 C CA   . THR A 1 198 ? -8.241  -2.945  15.546  1.00 49.02  ? 198 THR A CA   1 
ATOM   2919 C C    . THR A 1 198 ? -8.332  -2.284  14.176  1.00 45.06  ? 198 THR A C    1 
ATOM   2920 O O    . THR A 1 198 ? -7.919  -1.136  13.989  1.00 46.88  ? 198 THR A O    1 
ATOM   2921 C CB   . THR A 1 198 ? -9.634  -2.996  16.185  1.00 50.56  ? 198 THR A CB   1 
ATOM   2922 O OG1  . THR A 1 198 ? -9.943  -1.720  16.759  1.00 50.34  ? 198 THR A OG1  1 
ATOM   2923 C CG2  . THR A 1 198 ? -9.690  -4.073  17.254  1.00 60.68  ? 198 THR A CG2  1 
ATOM   2924 H H    . THR A 1 198 ? -7.411  -1.354  16.330  1.00 61.89  ? 198 THR A H    1 
ATOM   2925 H HA   . THR A 1 198 ? -7.931  -3.858  15.440  1.00 58.88  ? 198 THR A HA   1 
ATOM   2926 H HB   . THR A 1 198 ? -10.297 -3.209  15.510  1.00 60.73  ? 198 THR A HB   1 
ATOM   2927 H HG1  . THR A 1 198 ? -10.723 -1.727  17.070  1.00 60.46  ? 198 THR A HG1  1 
ATOM   2928 H HG21 . THR A 1 198 ? -10.259 -3.785  17.985  1.00 72.88  ? 198 THR A HG21 1 
ATOM   2929 H HG22 . THR A 1 198 ? -10.049 -4.893  16.881  1.00 72.88  ? 198 THR A HG22 1 
ATOM   2930 H HG23 . THR A 1 198 ? -8.800  -4.246  17.598  1.00 72.88  ? 198 THR A HG23 1 
ATOM   2931 N N    . THR A 1 199 ? -8.888  -3.020  13.220  1.00 50.57  ? 199 THR A N    1 
ATOM   2932 C CA   . THR A 1 199 ? -9.053  -2.533  11.857  1.00 41.14  ? 199 THR A CA   1 
ATOM   2933 C C    . THR A 1 199 ? -10.406 -1.847  11.714  1.00 41.73  ? 199 THR A C    1 
ATOM   2934 O O    . THR A 1 199 ? -11.422 -2.346  12.205  1.00 41.80  ? 199 THR A O    1 
ATOM   2935 C CB   . THR A 1 199 ? -8.934  -3.689  10.861  1.00 42.92  ? 199 THR A CB   1 
ATOM   2936 O OG1  . THR A 1 199 ? -7.649  -4.310  10.999  1.00 44.85  ? 199 THR A OG1  1 
ATOM   2937 C CG2  . THR A 1 199 ? -9.102  -3.193  9.435   1.00 47.39  ? 199 THR A CG2  1 
ATOM   2938 H H    . THR A 1 199 ? -9.183  -3.819  13.338  1.00 60.75  ? 199 THR A H    1 
ATOM   2939 H HA   . THR A 1 199 ? -8.361  -1.886  11.650  1.00 49.43  ? 199 THR A HA   1 
ATOM   2940 H HB   . THR A 1 199 ? -9.631  -4.339  11.039  1.00 51.56  ? 199 THR A HB   1 
ATOM   2941 H HG1  . THR A 1 199 ? -7.564  -4.923  10.432  1.00 53.88  ? 199 THR A HG1  1 
ATOM   2942 H HG21 . THR A 1 199 ? -8.845  -3.888  8.809   1.00 56.93  ? 199 THR A HG21 1 
ATOM   2943 H HG22 . THR A 1 199 ? -10.028 -2.951  9.275   1.00 56.93  ? 199 THR A HG22 1 
ATOM   2944 H HG23 . THR A 1 199 ? -8.544  -2.413  9.287   1.00 56.93  ? 199 THR A HG23 1 
ATOM   2945 N N    . ILE A 1 200 ? -10.416 -0.695  11.045  1.00 40.14  ? 200 ILE A N    1 
ATOM   2946 C CA   . ILE A 1 200 ? -11.633 0.109   10.927  1.00 36.14  ? 200 ILE A CA   1 
ATOM   2947 C C    . ILE A 1 200 ? -12.479 -0.487  9.805   1.00 45.04  ? 200 ILE A C    1 
ATOM   2948 O O    . ILE A 1 200 ? -12.203 -0.284  8.622   1.00 38.06  ? 200 ILE A O    1 
ATOM   2949 C CB   . ILE A 1 200 ? -11.325 1.585   10.676  1.00 34.42  ? 200 ILE A CB   1 
ATOM   2950 C CG1  . ILE A 1 200 ? -10.410 2.146   11.766  1.00 42.89  ? 200 ILE A CG1  1 
ATOM   2951 C CG2  . ILE A 1 200 ? -12.617 2.394   10.641  1.00 38.39  ? 200 ILE A CG2  1 
ATOM   2952 C CD1  . ILE A 1 200 ? -9.156  2.802   11.225  1.00 35.95  ? 200 ILE A CD1  1 
ATOM   2953 H H    . ILE A 1 200 ? -9.731  -0.358  10.650  1.00 48.23  ? 200 ILE A H    1 
ATOM   2954 H HA   . ILE A 1 200 ? -12.134 0.039   11.755  1.00 43.43  ? 200 ILE A HA   1 
ATOM   2955 H HB   . ILE A 1 200 ? -10.873 1.652   9.820   1.00 41.36  ? 200 ILE A HB   1 
ATOM   2956 H HG12 . ILE A 1 200 ? -10.899 2.813   12.273  1.00 51.53  ? 200 ILE A HG12 1 
ATOM   2957 H HG13 . ILE A 1 200 ? -10.137 1.420   12.349  1.00 51.53  ? 200 ILE A HG13 1 
ATOM   2958 H HG21 . ILE A 1 200 ? -12.398 3.337   10.592  1.00 46.12  ? 200 ILE A HG21 1 
ATOM   2959 H HG22 . ILE A 1 200 ? -13.132 2.133   9.861   1.00 46.12  ? 200 ILE A HG22 1 
ATOM   2960 H HG23 . ILE A 1 200 ? -13.125 2.213   11.447  1.00 46.12  ? 200 ILE A HG23 1 
ATOM   2961 H HD11 . ILE A 1 200 ? -8.639  3.154   11.966  1.00 43.20  ? 200 ILE A HD11 1 
ATOM   2962 H HD12 . ILE A 1 200 ? -8.636  2.140   10.743  1.00 43.20  ? 200 ILE A HD12 1 
ATOM   2963 H HD13 . ILE A 1 200 ? -9.410  3.523   10.627  1.00 43.20  ? 200 ILE A HD13 1 
ATOM   2964 N N    . THR A 1 201 ? -13.539 -1.204  10.188  1.00 39.52  ? 201 THR A N    1 
ATOM   2965 C CA   . THR A 1 201 ? -14.315 -1.977  9.224   1.00 44.60  ? 201 THR A CA   1 
ATOM   2966 C C    . THR A 1 201 ? -15.021 -1.078  8.216   1.00 44.85  ? 201 THR A C    1 
ATOM   2967 O O    . THR A 1 201 ? -14.963 -1.321  7.005   1.00 33.98  ? 201 THR A O    1 
ATOM   2968 C CB   . THR A 1 201 ? -15.340 -2.844  9.957   1.00 41.26  ? 201 THR A CB   1 
ATOM   2969 O OG1  . THR A 1 201 ? -14.702 -3.528  11.039  1.00 43.26  ? 201 THR A OG1  1 
ATOM   2970 C CG2  . THR A 1 201 ? -15.960 -3.849  9.003   1.00 49.41  ? 201 THR A CG2  1 
ATOM   2971 H H    . THR A 1 201 ? -13.827 -1.257  10.997  1.00 47.48  ? 201 THR A H    1 
ATOM   2972 H HA   . THR A 1 201 ? -13.705 -2.553  8.737   1.00 53.58  ? 201 THR A HA   1 
ATOM   2973 H HB   . THR A 1 201 ? -16.050 -2.285  10.310  1.00 49.57  ? 201 THR A HB   1 
ATOM   2974 H HG1  . THR A 1 201 ? -15.257 -4.020  11.435  1.00 51.97  ? 201 THR A HG1  1 
ATOM   2975 H HG21 . THR A 1 201 ? -16.546 -4.450  9.490   1.00 59.35  ? 201 THR A HG21 1 
ATOM   2976 H HG22 . THR A 1 201 ? -16.477 -3.387  8.324   1.00 59.35  ? 201 THR A HG22 1 
ATOM   2977 H HG23 . THR A 1 201 ? -15.265 -4.369  8.571   1.00 59.35  ? 201 THR A HG23 1 
ATOM   2978 N N    . VAL A 1 202 ? -15.726 -0.051  8.698   1.00 35.26  ? 202 VAL A N    1 
ATOM   2979 C CA   . VAL A 1 202 ? -16.489 0.797   7.786   1.00 33.80  ? 202 VAL A CA   1 
ATOM   2980 C C    . VAL A 1 202 ? -15.576 1.395   6.727   1.00 32.60  ? 202 VAL A C    1 
ATOM   2981 O O    . VAL A 1 202 ? -15.995 1.614   5.583   1.00 41.62  ? 202 VAL A O    1 
ATOM   2982 C CB   . VAL A 1 202 ? -17.242 1.895   8.560   1.00 40.86  ? 202 VAL A CB   1 
ATOM   2983 C CG1  . VAL A 1 202 ? -16.273 2.906   9.144   1.00 39.83  ? 202 VAL A CG1  1 
ATOM   2984 C CG2  . VAL A 1 202 ? -18.245 2.595   7.647   1.00 45.75  ? 202 VAL A CG2  1 
ATOM   2985 H H    . VAL A 1 202 ? -15.776 0.170   9.528   1.00 42.37  ? 202 VAL A H    1 
ATOM   2986 H HA   . VAL A 1 202 ? -17.151 0.244   7.342   1.00 40.61  ? 202 VAL A HA   1 
ATOM   2987 H HB   . VAL A 1 202 ? -17.723 1.480   9.293   1.00 49.08  ? 202 VAL A HB   1 
ATOM   2988 H HG11 . VAL A 1 202 ? -16.746 3.464   9.782   1.00 47.85  ? 202 VAL A HG11 1 
ATOM   2989 H HG12 . VAL A 1 202 ? -15.552 2.433   9.589   1.00 47.85  ? 202 VAL A HG12 1 
ATOM   2990 H HG13 . VAL A 1 202 ? -15.917 3.453   8.426   1.00 47.85  ? 202 VAL A HG13 1 
ATOM   2991 H HG21 . VAL A 1 202 ? -18.755 3.234   8.169   1.00 54.96  ? 202 VAL A HG21 1 
ATOM   2992 H HG22 . VAL A 1 202 ? -17.764 3.053   6.941   1.00 54.96  ? 202 VAL A HG22 1 
ATOM   2993 H HG23 . VAL A 1 202 ? -18.840 1.931   7.264   1.00 54.96  ? 202 VAL A HG23 1 
ATOM   2994 N N    . ASN A 1 203 ? -14.320 1.670   7.083   1.00 36.59  ? 203 ASN A N    1 
ATOM   2995 C CA   . ASN A 1 203 ? -13.383 2.221   6.111   1.00 35.71  ? 203 ASN A CA   1 
ATOM   2996 C C    . ASN A 1 203 ? -12.979 1.175   5.083   1.00 39.86  ? 203 ASN A C    1 
ATOM   2997 O O    . ASN A 1 203 ? -12.816 1.490   3.898   1.00 31.63  ? 203 ASN A O    1 
ATOM   2998 C CB   . ASN A 1 203 ? -12.148 2.768   6.826   1.00 38.67  ? 203 ASN A CB   1 
ATOM   2999 C CG   . ASN A 1 203 ? -12.429 4.056   7.569   1.00 41.98  ? 203 ASN A CG   1 
ATOM   3000 O OD1  . ASN A 1 203 ? -13.579 4.489   7.673   1.00 30.32  ? 203 ASN A OD1  1 
ATOM   3001 N ND2  . ASN A 1 203 ? -11.381 4.679   8.090   1.00 34.19  ? 203 ASN A ND2  1 
ATOM   3002 H H    . ASN A 1 203 ? -13.992 1.547   7.868   1.00 43.96  ? 203 ASN A H    1 
ATOM   3003 H HA   . ASN A 1 203 ? -13.813 2.955   5.644   1.00 42.91  ? 203 ASN A HA   1 
ATOM   3004 H HB2  . ASN A 1 203 ? -11.838 2.111   7.469   1.00 46.46  ? 203 ASN A HB2  1 
ATOM   3005 H HB3  . ASN A 1 203 ? -11.455 2.944   6.170   1.00 46.46  ? 203 ASN A HB3  1 
ATOM   3006 H HD21 . ASN A 1 203 ? -11.489 5.414   8.521   1.00 41.09  ? 203 ASN A HD21 1 
ATOM   3007 H HD22 . ASN A 1 203 ? -10.593 4.346   7.996   1.00 41.09  ? 203 ASN A HD22 1 
ATOM   3008 N N    . VAL A 1 204 ? -12.810 -0.075  5.517   1.00 34.76  ? 204 VAL A N    1 
ATOM   3009 C CA   . VAL A 1 204 ? -12.455 -1.140  4.584   1.00 30.27  ? 204 VAL A CA   1 
ATOM   3010 C C    . VAL A 1 204 ? -13.550 -1.308  3.539   1.00 40.58  ? 204 VAL A C    1 
ATOM   3011 O O    . VAL A 1 204 ? -13.278 -1.403  2.337   1.00 38.84  ? 204 VAL A O    1 
ATOM   3012 C CB   . VAL A 1 204 ? -12.196 -2.454  5.341   1.00 31.81  ? 204 VAL A CB   1 
ATOM   3013 C CG1  . VAL A 1 204 ? -12.088 -3.615  4.364   1.00 36.77  ? 204 VAL A CG1  1 
ATOM   3014 C CG2  . VAL A 1 204 ? -10.934 -2.350  6.182   1.00 35.69  ? 204 VAL A CG2  1 
ATOM   3015 H H    . VAL A 1 204 ? -12.894 -0.327  6.335   1.00 41.77  ? 204 VAL A H    1 
ATOM   3016 H HA   . VAL A 1 204 ? -11.636 -0.891  4.127   1.00 36.38  ? 204 VAL A HA   1 
ATOM   3017 H HB   . VAL A 1 204 ? -12.942 -2.623  5.938   1.00 38.23  ? 204 VAL A HB   1 
ATOM   3018 H HG11 . VAL A 1 204 ? -11.657 -4.363  4.808   1.00 44.18  ? 204 VAL A HG11 1 
ATOM   3019 H HG12 . VAL A 1 204 ? -12.978 -3.870  4.076   1.00 44.18  ? 204 VAL A HG12 1 
ATOM   3020 H HG13 . VAL A 1 204 ? -11.560 -3.337  3.599   1.00 44.18  ? 204 VAL A HG13 1 
ATOM   3021 H HG21 . VAL A 1 204 ? -10.797 -3.187  6.652   1.00 42.89  ? 204 VAL A HG21 1 
ATOM   3022 H HG22 . VAL A 1 204 ? -10.180 -2.171  5.598   1.00 42.89  ? 204 VAL A HG22 1 
ATOM   3023 H HG23 . VAL A 1 204 ? -11.038 -1.626  6.819   1.00 42.89  ? 204 VAL A HG23 1 
ATOM   3024 N N    . LEU A 1 205 ? -14.808 -1.350  3.984   1.00 38.91  ? 205 LEU A N    1 
ATOM   3025 C CA   . LEU A 1 205 ? -15.921 -1.453  3.046   1.00 36.25  ? 205 LEU A CA   1 
ATOM   3026 C C    . LEU A 1 205 ? -15.933 -0.268  2.092   1.00 35.68  ? 205 LEU A C    1 
ATOM   3027 O O    . LEU A 1 205 ? -16.091 -0.431  0.877   1.00 43.22  ? 205 LEU A O    1 
ATOM   3028 C CB   . LEU A 1 205 ? -17.244 -1.537  3.805   1.00 44.75  ? 205 LEU A CB   1 
ATOM   3029 C CG   . LEU A 1 205 ? -17.472 -2.804  4.628   1.00 35.51  ? 205 LEU A CG   1 
ATOM   3030 C CD1  . LEU A 1 205 ? -18.662 -2.624  5.555   1.00 41.87  ? 205 LEU A CD1  1 
ATOM   3031 C CD2  . LEU A 1 205 ? -17.677 -4.007  3.722   1.00 47.90  ? 205 LEU A CD2  1 
ATOM   3032 H H    . LEU A 1 205 ? -15.039 -1.321  4.812   1.00 46.75  ? 205 LEU A H    1 
ATOM   3033 H HA   . LEU A 1 205 ? -15.820 -2.267  2.528   1.00 43.55  ? 205 LEU A HA   1 
ATOM   3034 H HB2  . LEU A 1 205 ? -17.288 -0.787  4.418   1.00 53.76  ? 205 LEU A HB2  1 
ATOM   3035 H HB3  . LEU A 1 205 ? -17.966 -1.482  3.160   1.00 53.76  ? 205 LEU A HB3  1 
ATOM   3036 H HG   . LEU A 1 205 ? -16.686 -2.973  5.172   1.00 42.67  ? 205 LEU A HG   1 
ATOM   3037 H HD11 . LEU A 1 205 ? -18.796 -3.441  6.060   1.00 50.31  ? 205 LEU A HD11 1 
ATOM   3038 H HD12 . LEU A 1 205 ? -18.484 -1.886  6.159   1.00 50.31  ? 205 LEU A HD12 1 
ATOM   3039 H HD13 . LEU A 1 205 ? -19.450 -2.432  5.023   1.00 50.31  ? 205 LEU A HD13 1 
ATOM   3040 H HD21 . LEU A 1 205 ? -17.880 -4.782  4.268   1.00 57.53  ? 205 LEU A HD21 1 
ATOM   3041 H HD22 . LEU A 1 205 ? -18.414 -3.825  3.118   1.00 57.53  ? 205 LEU A HD22 1 
ATOM   3042 H HD23 . LEU A 1 205 ? -16.865 -4.162  3.215   1.00 57.53  ? 205 LEU A HD23 1 
ATOM   3043 N N    . ALA A 1 206 ? -15.771 0.942   2.631   1.00 31.19  ? 206 ALA A N    1 
ATOM   3044 C CA   . ALA A 1 206 ? -15.730 2.124   1.778   1.00 31.64  ? 206 ALA A CA   1 
ATOM   3045 C C    . ALA A 1 206 ? -14.648 1.988   0.714   1.00 38.50  ? 206 ALA A C    1 
ATOM   3046 O O    . ALA A 1 206 ? -14.872 2.313   -0.456  1.00 44.22  ? 206 ALA A O    1 
ATOM   3047 C CB   . ALA A 1 206 ? -15.501 3.372   2.633   1.00 34.98  ? 206 ALA A CB   1 
ATOM   3048 H H    . ALA A 1 206 ? -15.684 1.101   3.472   1.00 37.49  ? 206 ALA A H    1 
ATOM   3049 H HA   . ALA A 1 206 ? -16.582 2.226   1.327   1.00 38.03  ? 206 ALA A HA   1 
ATOM   3050 H HB1  . ALA A 1 206 ? -15.468 4.149   2.054   1.00 42.04  ? 206 ALA A HB1  1 
ATOM   3051 H HB2  . ALA A 1 206 ? -16.231 3.460   3.264   1.00 42.04  ? 206 ALA A HB2  1 
ATOM   3052 H HB3  . ALA A 1 206 ? -14.661 3.278   3.109   1.00 42.04  ? 206 ALA A HB3  1 
ATOM   3053 N N    . TRP A 1 207 ? -13.474 1.492   1.102   1.00 36.29  ? 207 TRP A N    1 
ATOM   3054 C CA   . TRP A 1 207 ? -12.389 1.281   0.150   1.00 41.43  ? 207 TRP A CA   1 
ATOM   3055 C C    . TRP A 1 207 ? -12.756 0.224   -0.881  1.00 42.65  ? 207 TRP A C    1 
ATOM   3056 O O    . TRP A 1 207 ? -12.389 0.346   -2.055  1.00 36.61  ? 207 TRP A O    1 
ATOM   3057 C CB   . TRP A 1 207 ? -11.130 0.910   0.932   1.00 36.16  ? 207 TRP A CB   1 
ATOM   3058 C CG   . TRP A 1 207 ? -9.945  0.467   0.149   1.00 38.03  ? 207 TRP A CG   1 
ATOM   3059 C CD1  . TRP A 1 207 ? -9.067  1.253   -0.541  1.00 35.03  ? 207 TRP A CD1  1 
ATOM   3060 C CD2  . TRP A 1 207 ? -9.475  -0.875  0.014   1.00 31.37  ? 207 TRP A CD2  1 
ATOM   3061 N NE1  . TRP A 1 207 ? -8.085  0.477   -1.107  1.00 35.45  ? 207 TRP A NE1  1 
ATOM   3062 C CE2  . TRP A 1 207 ? -8.316  -0.834  -0.783  1.00 33.24  ? 207 TRP A CE2  1 
ATOM   3063 C CE3  . TRP A 1 207 ? -9.928  -2.110  0.485   1.00 36.58  ? 207 TRP A CE3  1 
ATOM   3064 C CZ2  . TRP A 1 207 ? -7.606  -1.981  -1.121  1.00 33.44  ? 207 TRP A CZ2  1 
ATOM   3065 C CZ3  . TRP A 1 207 ? -9.225  -3.244  0.147   1.00 36.10  ? 207 TRP A CZ3  1 
ATOM   3066 C CH2  . TRP A 1 207 ? -8.075  -3.174  -0.644  1.00 33.52  ? 207 TRP A CH2  1 
ATOM   3067 H H    . TRP A 1 207 ? -13.280 1.271   1.910   1.00 43.61  ? 207 TRP A H    1 
ATOM   3068 H HA   . TRP A 1 207 ? -12.208 2.095   -0.347  1.00 49.77  ? 207 TRP A HA   1 
ATOM   3069 H HB2  . TRP A 1 207 ? -10.855 1.689   1.441   1.00 43.45  ? 207 TRP A HB2  1 
ATOM   3070 H HB3  . TRP A 1 207 ? -11.356 0.184   1.534   1.00 43.45  ? 207 TRP A HB3  1 
ATOM   3071 H HD1  . TRP A 1 207 ? -9.126  2.178   -0.617  1.00 42.09  ? 207 TRP A HD1  1 
ATOM   3072 H HE1  . TRP A 1 207 ? -7.432  0.767   -1.586  1.00 42.60  ? 207 TRP A HE1  1 
ATOM   3073 H HE3  . TRP A 1 207 ? -10.689 -2.164  1.017   1.00 43.96  ? 207 TRP A HE3  1 
ATOM   3074 H HZ2  . TRP A 1 207 ? -6.842  -1.939  -1.650  1.00 40.19  ? 207 TRP A HZ2  1 
ATOM   3075 H HZ3  . TRP A 1 207 ? -9.521  -4.072  0.451   1.00 43.37  ? 207 TRP A HZ3  1 
ATOM   3076 H HH2  . TRP A 1 207 ? -7.619  -3.957  -0.852  1.00 40.28  ? 207 TRP A HH2  1 
ATOM   3077 N N    . LEU A 1 208 ? -13.495 -0.808  -0.473  1.00 34.63  ? 208 LEU A N    1 
ATOM   3078 C CA   . LEU A 1 208 ? -13.954 -1.803  -1.437  1.00 44.64  ? 208 LEU A CA   1 
ATOM   3079 C C    . LEU A 1 208 ? -14.911 -1.178  -2.442  1.00 42.04  ? 208 LEU A C    1 
ATOM   3080 O O    . LEU A 1 208 ? -14.892 -1.526  -3.628  1.00 38.33  ? 208 LEU A O    1 
ATOM   3081 C CB   . LEU A 1 208 ? -14.620 -2.966  -0.710  1.00 41.96  ? 208 LEU A CB   1 
ATOM   3082 C CG   . LEU A 1 208 ? -13.669 -3.876  0.068   1.00 34.89  ? 208 LEU A CG   1 
ATOM   3083 C CD1  . LEU A 1 208 ? -14.454 -4.982  0.764   1.00 41.17  ? 208 LEU A CD1  1 
ATOM   3084 C CD2  . LEU A 1 208 ? -12.594 -4.480  -0.824  1.00 38.76  ? 208 LEU A CD2  1 
ATOM   3085 H H    . LEU A 1 208 ? -13.739 -0.952  0.339   1.00 41.61  ? 208 LEU A H    1 
ATOM   3086 H HA   . LEU A 1 208 ? -13.191 -2.153  -1.921  1.00 53.62  ? 208 LEU A HA   1 
ATOM   3087 H HB2  . LEU A 1 208 ? -15.260 -2.605  -0.077  1.00 50.41  ? 208 LEU A HB2  1 
ATOM   3088 H HB3  . LEU A 1 208 ? -15.076 -3.516  -1.366  1.00 50.41  ? 208 LEU A HB3  1 
ATOM   3089 H HG   . LEU A 1 208 ? -13.216 -3.337  0.735   1.00 41.93  ? 208 LEU A HG   1 
ATOM   3090 H HD11 . LEU A 1 208 ? -13.839 -5.534  1.272   1.00 49.46  ? 208 LEU A HD11 1 
ATOM   3091 H HD12 . LEU A 1 208 ? -15.106 -4.579  1.359   1.00 49.46  ? 208 LEU A HD12 1 
ATOM   3092 H HD13 . LEU A 1 208 ? -14.905 -5.519  0.094   1.00 49.46  ? 208 LEU A HD13 1 
ATOM   3093 H HD21 . LEU A 1 208 ? -12.147 -5.193  -0.342  1.00 46.57  ? 208 LEU A HD21 1 
ATOM   3094 H HD22 . LEU A 1 208 ? -13.010 -4.834  -1.626  1.00 46.57  ? 208 LEU A HD22 1 
ATOM   3095 H HD23 . LEU A 1 208 ? -11.955 -3.790  -1.061  1.00 46.57  ? 208 LEU A HD23 1 
ATOM   3096 N N    . TYR A 1 209 ? -15.757 -0.251  -1.988  1.00 43.45  ? 209 TYR A N    1 
ATOM   3097 C CA   . TYR A 1 209 ? -16.633 0.455   -2.916  1.00 39.32  ? 209 TYR A CA   1 
ATOM   3098 C C    . TYR A 1 209 ? -15.827 1.308   -3.886  1.00 45.42  ? 209 TYR A C    1 
ATOM   3099 O O    . TYR A 1 209 ? -16.111 1.329   -5.089  1.00 39.37  ? 209 TYR A O    1 
ATOM   3100 C CB   . TYR A 1 209 ? -17.627 1.317   -2.144  1.00 38.98  ? 209 TYR A CB   1 
ATOM   3101 C CG   . TYR A 1 209 ? -18.828 0.549   -1.650  1.00 42.59  ? 209 TYR A CG   1 
ATOM   3102 C CD1  . TYR A 1 209 ? -19.823 0.134   -2.526  1.00 50.10  ? 209 TYR A CD1  1 
ATOM   3103 C CD2  . TYR A 1 209 ? -18.965 0.238   -0.306  1.00 41.80  ? 209 TYR A CD2  1 
ATOM   3104 C CE1  . TYR A 1 209 ? -20.922 -0.569  -2.072  1.00 42.95  ? 209 TYR A CE1  1 
ATOM   3105 C CE2  . TYR A 1 209 ? -20.058 -0.462  0.155   1.00 40.59  ? 209 TYR A CE2  1 
ATOM   3106 C CZ   . TYR A 1 209 ? -21.032 -0.862  -0.731  1.00 47.55  ? 209 TYR A CZ   1 
ATOM   3107 O OH   . TYR A 1 209 ? -22.119 -1.560  -0.261  1.00 45.51  ? 209 TYR A OH   1 
ATOM   3108 H H    . TYR A 1 209 ? -15.841 -0.019  -1.164  1.00 52.19  ? 209 TYR A H    1 
ATOM   3109 H HA   . TYR A 1 209 ? -17.136 -0.195  -3.431  1.00 47.25  ? 209 TYR A HA   1 
ATOM   3110 H HB2  . TYR A 1 209 ? -17.178 1.697   -1.373  1.00 46.83  ? 209 TYR A HB2  1 
ATOM   3111 H HB3  . TYR A 1 209 ? -17.945 2.025   -2.726  1.00 46.83  ? 209 TYR A HB3  1 
ATOM   3112 H HD1  . TYR A 1 209 ? -19.748 0.333   -3.431  1.00 60.17  ? 209 TYR A HD1  1 
ATOM   3113 H HD2  . TYR A 1 209 ? -18.307 0.506   0.294   1.00 50.22  ? 209 TYR A HD2  1 
ATOM   3114 H HE1  . TYR A 1 209 ? -21.583 -0.841  -2.667  1.00 51.59  ? 209 TYR A HE1  1 
ATOM   3115 H HE2  . TYR A 1 209 ? -20.137 -0.662  1.060   1.00 48.77  ? 209 TYR A HE2  1 
ATOM   3116 H HH   . TYR A 1 209 ? -22.645 -1.731  -0.893  1.00 54.67  ? 209 TYR A HH   1 
ATOM   3117 N N    . ALA A 1 210 ? -14.820 2.025   -3.380  1.00 37.50  ? 210 ALA A N    1 
ATOM   3118 C CA   . ALA A 1 210 ? -13.924 2.764   -4.263  1.00 36.80  ? 210 ALA A CA   1 
ATOM   3119 C C    . ALA A 1 210 ? -13.331 1.840   -5.315  1.00 38.73  ? 210 ALA A C    1 
ATOM   3120 O O    . ALA A 1 210 ? -13.149 2.232   -6.473  1.00 33.46  ? 210 ALA A O    1 
ATOM   3121 C CB   . ALA A 1 210 ? -12.816 3.431   -3.447  1.00 41.89  ? 210 ALA A CB   1 
ATOM   3122 H H    . ALA A 1 210 ? -14.638 2.098   -2.542  1.00 45.06  ? 210 ALA A H    1 
ATOM   3123 H HA   . ALA A 1 210 ? -14.423 3.464   -4.713  1.00 44.21  ? 210 ALA A HA   1 
ATOM   3124 H HB1  . ALA A 1 210 ? -12.247 3.940   -4.045  1.00 50.32  ? 210 ALA A HB1  1 
ATOM   3125 H HB2  . ALA A 1 210 ? -13.219 4.021   -2.791  1.00 50.32  ? 210 ALA A HB2  1 
ATOM   3126 H HB3  . ALA A 1 210 ? -12.297 2.745   -2.999  1.00 50.32  ? 210 ALA A HB3  1 
ATOM   3127 N N    . ALA A 1 211 ? -13.021 0.603   -4.925  1.00 35.07  ? 211 ALA A N    1 
ATOM   3128 C CA   . ALA A 1 211 ? -12.470 -0.363  -5.868  1.00 32.57  ? 211 ALA A CA   1 
ATOM   3129 C C    . ALA A 1 211 ? -13.478 -0.691  -6.963  1.00 39.94  ? 211 ALA A C    1 
ATOM   3130 O O    . ALA A 1 211 ? -13.135 -0.703  -8.152  1.00 36.10  ? 211 ALA A O    1 
ATOM   3131 C CB   . ALA A 1 211 ? -12.046 -1.630  -5.123  1.00 30.74  ? 211 ALA A CB   1 
ATOM   3132 H H    . ALA A 1 211 ? -13.120 0.302   -4.125  1.00 42.14  ? 211 ALA A H    1 
ATOM   3133 H HA   . ALA A 1 211 ? -11.684 0.018   -6.289  1.00 39.15  ? 211 ALA A HA   1 
ATOM   3134 H HB1  . ALA A 1 211 ? -11.648 -2.249  -5.755  1.00 36.94  ? 211 ALA A HB1  1 
ATOM   3135 H HB2  . ALA A 1 211 ? -11.399 -1.393  -4.441  1.00 36.94  ? 211 ALA A HB2  1 
ATOM   3136 H HB3  . ALA A 1 211 ? -12.827 -2.032  -4.713  1.00 36.94  ? 211 ALA A HB3  1 
ATOM   3137 N N    . VAL A 1 212 ? -14.730 -0.953  -6.578  1.00 38.08  ? 212 VAL A N    1 
ATOM   3138 C CA   . VAL A 1 212 ? -15.769 -1.235  -7.565  1.00 36.27  ? 212 VAL A CA   1 
ATOM   3139 C C    . VAL A 1 212 ? -15.929 -0.053  -8.513  1.00 42.15  ? 212 VAL A C    1 
ATOM   3140 O O    . VAL A 1 212 ? -16.022 -0.221  -9.735  1.00 45.93  ? 212 VAL A O    1 
ATOM   3141 C CB   . VAL A 1 212 ? -17.098 -1.577  -6.866  1.00 40.77  ? 212 VAL A CB   1 
ATOM   3142 C CG1  . VAL A 1 212 ? -18.240 -1.627  -7.878  1.00 45.54  ? 212 VAL A CG1  1 
ATOM   3143 C CG2  . VAL A 1 212 ? -16.980 -2.895  -6.114  1.00 36.21  ? 212 VAL A CG2  1 
ATOM   3144 H H    . VAL A 1 212 ? -14.998 -0.974  -5.761  1.00 45.75  ? 212 VAL A H    1 
ATOM   3145 H HA   . VAL A 1 212 ? -15.497 -2.006  -8.087  1.00 43.58  ? 212 VAL A HA   1 
ATOM   3146 H HB   . VAL A 1 212 ? -17.302 -0.882  -6.221  1.00 48.98  ? 212 VAL A HB   1 
ATOM   3147 H HG11 . VAL A 1 212 ? -18.994 -2.089  -7.480  1.00 54.71  ? 212 VAL A HG11 1 
ATOM   3148 H HG12 . VAL A 1 212 ? -18.493 -0.721  -8.114  1.00 54.71  ? 212 VAL A HG12 1 
ATOM   3149 H HG13 . VAL A 1 212 ? -17.940 -2.103  -8.668  1.00 54.71  ? 212 VAL A HG13 1 
ATOM   3150 H HG21 . VAL A 1 212 ? -17.850 -3.136  -5.761  1.00 43.51  ? 212 VAL A HG21 1 
ATOM   3151 H HG22 . VAL A 1 212 ? -16.670 -3.581  -6.727  1.00 43.51  ? 212 VAL A HG22 1 
ATOM   3152 H HG23 . VAL A 1 212 ? -16.345 -2.789  -5.388  1.00 43.51  ? 212 VAL A HG23 1 
ATOM   3153 N N    . ILE A 1 213 ? -15.967 1.162   -7.964  1.00 39.11  ? 213 ILE A N    1 
ATOM   3154 C CA   . ILE A 1 213 ? -16.107 2.341   -8.812  1.00 36.38  ? 213 ILE A CA   1 
ATOM   3155 C C    . ILE A 1 213 ? -14.971 2.412   -9.824  1.00 44.97  ? 213 ILE A C    1 
ATOM   3156 O O    . ILE A 1 213 ? -15.148 2.938   -10.930 1.00 47.54  ? 213 ILE A O    1 
ATOM   3157 C CB   . ILE A 1 213 ? -16.182 3.619   -7.949  1.00 40.52  ? 213 ILE A CB   1 
ATOM   3158 C CG1  . ILE A 1 213 ? -17.492 3.640   -7.152  1.00 42.80  ? 213 ILE A CG1  1 
ATOM   3159 C CG2  . ILE A 1 213 ? -16.058 4.860   -8.825  1.00 44.06  ? 213 ILE A CG2  1 
ATOM   3160 C CD1  . ILE A 1 213 ? -17.504 4.624   -5.990  1.00 42.73  ? 213 ILE A CD1  1 
ATOM   3161 H H    . ILE A 1 213 ? -15.914 1.326   -7.122  1.00 46.99  ? 213 ILE A H    1 
ATOM   3162 H HA   . ILE A 1 213 ? -16.940 2.268   -9.304  1.00 43.71  ? 213 ILE A HA   1 
ATOM   3163 H HB   . ILE A 1 213 ? -15.442 3.615   -7.322  1.00 48.68  ? 213 ILE A HB   1 
ATOM   3164 H HG12 . ILE A 1 213 ? -18.214 3.884   -7.752  1.00 51.42  ? 213 ILE A HG12 1 
ATOM   3165 H HG13 . ILE A 1 213 ? -17.647 2.754   -6.789  1.00 51.42  ? 213 ILE A HG13 1 
ATOM   3166 H HG21 . ILE A 1 213 ? -16.377 5.630   -8.329  1.00 52.93  ? 213 ILE A HG21 1 
ATOM   3167 H HG22 . ILE A 1 213 ? -15.126 4.985   -9.066  1.00 52.93  ? 213 ILE A HG22 1 
ATOM   3168 H HG23 . ILE A 1 213 ? -16.592 4.737   -9.625  1.00 52.93  ? 213 ILE A HG23 1 
ATOM   3169 H HD11 . ILE A 1 213 ? -18.320 4.499   -5.480  1.00 51.33  ? 213 ILE A HD11 1 
ATOM   3170 H HD12 . ILE A 1 213 ? -16.733 4.457   -5.427  1.00 51.33  ? 213 ILE A HD12 1 
ATOM   3171 H HD13 . ILE A 1 213 ? -17.468 5.527   -6.341  1.00 51.33  ? 213 ILE A HD13 1 
ATOM   3172 N N    . ASN A 1 214 ? -13.803 1.870   -9.485  1.00 41.29  ? 214 ASN A N    1 
ATOM   3173 C CA   . ASN A 1 214 ? -12.635 1.952   -10.350 1.00 52.90  ? 214 ASN A CA   1 
ATOM   3174 C C    . ASN A 1 214 ? -12.393 0.685   -11.165 1.00 49.69  ? 214 ASN A C    1 
ATOM   3175 O O    . ASN A 1 214 ? -11.327 0.549   -11.773 1.00 44.20  ? 214 ASN A O    1 
ATOM   3176 C CB   . ASN A 1 214 ? -11.396 2.287   -9.518  1.00 42.70  ? 214 ASN A CB   1 
ATOM   3177 C CG   . ASN A 1 214 ? -11.263 3.772   -9.251  1.00 59.95  ? 214 ASN A CG   1 
ATOM   3178 O OD1  . ASN A 1 214 ? -10.477 4.461   -9.900  1.00 56.36  ? 214 ASN A OD1  1 
ATOM   3179 N ND2  . ASN A 1 214 ? -12.048 4.278   -8.307  1.00 54.74  ? 214 ASN A ND2  1 
ATOM   3180 H H    . ASN A 1 214 ? -13.663 1.446   -8.750  1.00 49.61  ? 214 ASN A H    1 
ATOM   3181 H HA   . ASN A 1 214 ? -12.779 2.671   -10.985 1.00 63.53  ? 214 ASN A HA   1 
ATOM   3182 H HB2  . ASN A 1 214 ? -11.455 1.831   -8.664  1.00 51.30  ? 214 ASN A HB2  1 
ATOM   3183 H HB3  . ASN A 1 214 ? -10.604 1.995   -9.996  1.00 51.30  ? 214 ASN A HB3  1 
ATOM   3184 H HD21 . ASN A 1 214 ? -12.596 3.768   -7.884  1.00 65.75  ? 214 ASN A HD21 1 
ATOM   3185 H HD22 . ASN A 1 214 ? -12.008 5.116   -8.119  1.00 65.75  ? 214 ASN A HD22 1 
ATOM   3186 N N    . GLY A 1 215 ? -13.354 -0.234  -11.206 1.00 46.13  ? 215 GLY A N    1 
ATOM   3187 C CA   . GLY A 1 215 ? -13.285 -1.369  -12.099 1.00 47.51  ? 215 GLY A CA   1 
ATOM   3188 C C    . GLY A 1 215 ? -12.814 -2.667  -11.481 1.00 49.21  ? 215 GLY A C    1 
ATOM   3189 O O    . GLY A 1 215 ? -12.852 -3.700  -12.161 1.00 47.01  ? 215 GLY A O    1 
ATOM   3190 H H    . GLY A 1 215 ? -14.062 -0.215  -10.718 1.00 55.42  ? 215 GLY A H    1 
ATOM   3191 H HA2  . GLY A 1 215 ? -14.170 -1.525  -12.465 1.00 57.07  ? 215 GLY A HA2  1 
ATOM   3192 H HA3  . GLY A 1 215 ? -12.677 -1.153  -12.824 1.00 57.07  ? 215 GLY A HA3  1 
ATOM   3193 N N    . ASP A 1 216 ? -12.363 -2.654  -10.231 1.00 41.45  ? 216 ASP A N    1 
ATOM   3194 C CA   . ASP A 1 216 ? -11.982 -3.889  -9.558  1.00 41.02  ? 216 ASP A CA   1 
ATOM   3195 C C    . ASP A 1 216 ? -13.236 -4.573  -9.023  1.00 54.32  ? 216 ASP A C    1 
ATOM   3196 O O    . ASP A 1 216 ? -13.917 -4.028  -8.146  1.00 47.74  ? 216 ASP A O    1 
ATOM   3197 C CB   . ASP A 1 216 ? -10.994 -3.617  -8.424  1.00 57.08  ? 216 ASP A CB   1 
ATOM   3198 C CG   . ASP A 1 216 ? -9.592  -3.302  -8.926  1.00 60.80  ? 216 ASP A CG   1 
ATOM   3199 O OD1  . ASP A 1 216 ? -9.234  -3.745  -10.038 1.00 69.13  ? 216 ASP A OD1  1 
ATOM   3200 O OD2  . ASP A 1 216 ? -8.842  -2.620  -8.195  1.00 58.75  ? 216 ASP A OD2  1 
ATOM   3201 H H    . ASP A 1 216 ? -12.269 -1.945  -9.754  1.00 49.80  ? 216 ASP A H    1 
ATOM   3202 H HA   . ASP A 1 216 ? -11.545 -4.476  -10.195 1.00 49.28  ? 216 ASP A HA   1 
ATOM   3203 H HB2  . ASP A 1 216 ? -11.306 -2.856  -7.909  1.00 68.55  ? 216 ASP A HB2  1 
ATOM   3204 H HB3  . ASP A 1 216 ? -10.940 -4.402  -7.856  1.00 68.55  ? 216 ASP A HB3  1 
ATOM   3205 N N    . ARG A 1 217 ? -13.545 -5.757  -9.559  1.00 52.30  ? 217 ARG A N    1 
ATOM   3206 C CA   . ARG A 1 217 ? -14.774 -6.458  -9.227  1.00 46.27  ? 217 ARG A CA   1 
ATOM   3207 C C    . ARG A 1 217 ? -14.577 -7.929  -8.889  1.00 39.03  ? 217 ARG A C    1 
ATOM   3208 O O    . ARG A 1 217 ? -15.563 -8.614  -8.592  1.00 47.67  ? 217 ARG A O    1 
ATOM   3209 C CB   . ARG A 1 217 ? -15.772 -6.365  -10.394 1.00 45.99  ? 217 ARG A CB   1 
ATOM   3210 C CG   . ARG A 1 217 ? -16.114 -4.950  -10.826 1.00 51.22  ? 217 ARG A CG   1 
ATOM   3211 C CD   . ARG A 1 217 ? -17.210 -4.942  -11.890 1.00 47.41  ? 217 ARG A CD   1 
ATOM   3212 N NE   . ARG A 1 217 ? -18.425 -5.615  -11.445 1.00 46.96  ? 217 ARG A NE   1 
ATOM   3213 C CZ   . ARG A 1 217 ? -19.476 -5.002  -10.917 1.00 42.84  ? 217 ARG A CZ   1 
ATOM   3214 N NH1  . ARG A 1 217 ? -19.504 -3.689  -10.757 1.00 39.93  ? 217 ARG A NH1  1 
ATOM   3215 N NH2  . ARG A 1 217 ? -20.524 -5.726  -10.537 1.00 42.21  ? 217 ARG A NH2  1 
ATOM   3216 H H    . ARG A 1 217 ? -13.048 -6.175  -10.123 1.00 62.82  ? 217 ARG A H    1 
ATOM   3217 H HA   . ARG A 1 217 ? -15.162 -6.024  -8.451  1.00 55.58  ? 217 ARG A HA   1 
ATOM   3218 H HB2  . ARG A 1 217 ? -15.391 -6.821  -11.161 1.00 55.25  ? 217 ARG A HB2  1 
ATOM   3219 H HB3  . ARG A 1 217 ? -16.598 -6.797  -10.127 1.00 55.25  ? 217 ARG A HB3  1 
ATOM   3220 H HG2  . ARG A 1 217 ? -16.430 -4.447  -10.059 1.00 61.52  ? 217 ARG A HG2  1 
ATOM   3221 H HG3  . ARG A 1 217 ? -15.325 -4.528  -11.198 1.00 61.52  ? 217 ARG A HG3  1 
ATOM   3222 H HD2  . ARG A 1 217 ? -17.436 -4.023  -12.105 1.00 56.95  ? 217 ARG A HD2  1 
ATOM   3223 H HD3  . ARG A 1 217 ? -16.886 -5.398  -12.682 1.00 56.95  ? 217 ARG A HD3  1 
ATOM   3224 H HE   . ARG A 1 217 ? -18.463 -6.469  -11.532 1.00 56.41  ? 217 ARG A HE   1 
ATOM   3225 H HH11 . ARG A 1 217 ? -18.830 -3.212  -10.997 1.00 47.97  ? 217 ARG A HH11 1 
ATOM   3226 H HH12 . ARG A 1 217 ? -20.196 -3.313  -10.412 1.00 47.97  ? 217 ARG A HH12 1 
ATOM   3227 H HH21 . ARG A 1 217 ? -20.515 -6.580  -10.635 1.00 50.71  ? 217 ARG A HH21 1 
ATOM   3228 H HH22 . ARG A 1 217 ? -21.211 -5.339  -10.193 1.00 50.71  ? 217 ARG A HH22 1 
ATOM   3229 N N    . TRP A 1 218 ? -13.344 -8.437  -8.922  1.00 40.23  ? 218 TRP A N    1 
ATOM   3230 C CA   . TRP A 1 218 ? -13.140 -9.873  -8.771  1.00 48.09  ? 218 TRP A CA   1 
ATOM   3231 C C    . TRP A 1 218 ? -13.570 -10.393 -7.405  1.00 50.15  ? 218 TRP A C    1 
ATOM   3232 O O    . TRP A 1 218 ? -13.824 -11.596 -7.270  1.00 49.05  ? 218 TRP A O    1 
ATOM   3233 C CB   . TRP A 1 218 ? -11.669 -10.223 -9.006  1.00 55.70  ? 218 TRP A CB   1 
ATOM   3234 C CG   . TRP A 1 218 ? -10.712 -9.579  -8.038  1.00 51.83  ? 218 TRP A CG   1 
ATOM   3235 C CD1  . TRP A 1 218 ? -10.017 -8.420  -8.226  1.00 49.62  ? 218 TRP A CD1  1 
ATOM   3236 C CD2  . TRP A 1 218 ? -10.336 -10.064 -6.741  1.00 52.67  ? 218 TRP A CD2  1 
ATOM   3237 N NE1  . TRP A 1 218 ? -9.234  -8.152  -7.128  1.00 55.97  ? 218 TRP A NE1  1 
ATOM   3238 C CE2  . TRP A 1 218 ? -9.413  -9.145  -6.202  1.00 53.49  ? 218 TRP A CE2  1 
ATOM   3239 C CE3  . TRP A 1 218 ? -10.695 -11.181 -5.980  1.00 52.05  ? 218 TRP A CE3  1 
ATOM   3240 C CZ2  . TRP A 1 218 ? -8.843  -9.311  -4.941  1.00 48.75  ? 218 TRP A CZ2  1 
ATOM   3241 C CZ3  . TRP A 1 218 ? -10.124 -11.346 -4.730  1.00 52.63  ? 218 TRP A CZ3  1 
ATOM   3242 C CH2  . TRP A 1 218 ? -9.210  -10.415 -4.222  1.00 55.06  ? 218 TRP A CH2  1 
ATOM   3243 H H    . TRP A 1 218 ? -12.624 -7.979  -9.028  1.00 48.34  ? 218 TRP A H    1 
ATOM   3244 H HA   . TRP A 1 218 ? -13.677 -10.323 -9.441  1.00 57.77  ? 218 TRP A HA   1 
ATOM   3245 H HB2  . TRP A 1 218 ? -11.563 -11.184 -8.928  1.00 66.89  ? 218 TRP A HB2  1 
ATOM   3246 H HB3  . TRP A 1 218 ? -11.421 -9.933  -9.898  1.00 66.89  ? 218 TRP A HB3  1 
ATOM   3247 H HD1  . TRP A 1 218 ? -10.065 -7.889  -8.987  1.00 59.60  ? 218 TRP A HD1  1 
ATOM   3248 H HE1  . TRP A 1 218 ? -8.716  -7.471  -7.038  1.00 67.22  ? 218 TRP A HE1  1 
ATOM   3249 H HE3  . TRP A 1 218 ? -11.305 -11.802 -6.308  1.00 62.52  ? 218 TRP A HE3  1 
ATOM   3250 H HZ2  . TRP A 1 218 ? -8.235  -8.694  -4.602  1.00 58.56  ? 218 TRP A HZ2  1 
ATOM   3251 H HZ3  . TRP A 1 218 ? -10.351 -12.088 -4.218  1.00 63.21  ? 218 TRP A HZ3  1 
ATOM   3252 H HH2  . TRP A 1 218 ? -8.844  -10.551 -3.378  1.00 66.13  ? 218 TRP A HH2  1 
ATOM   3253 N N    . PHE A 1 219 ? -13.652 -9.528  -6.394  1.00 44.06  ? 219 PHE A N    1 
ATOM   3254 C CA   . PHE A 1 219 ? -13.980 -9.946  -5.036  1.00 44.64  ? 219 PHE A CA   1 
ATOM   3255 C C    . PHE A 1 219 ? -15.478 -9.968  -4.765  1.00 44.05  ? 219 PHE A C    1 
ATOM   3256 O O    . PHE A 1 219 ? -15.889 -10.346 -3.663  1.00 43.76  ? 219 PHE A O    1 
ATOM   3257 C CB   . PHE A 1 219 ? -13.296 -9.023  -4.019  1.00 38.57  ? 219 PHE A CB   1 
ATOM   3258 C CG   . PHE A 1 219 ? -13.583 -7.564  -4.236  1.00 35.59  ? 219 PHE A CG   1 
ATOM   3259 C CD1  . PHE A 1 219 ? -14.753 -6.994  -3.761  1.00 39.89  ? 219 PHE A CD1  1 
ATOM   3260 C CD2  . PHE A 1 219 ? -12.689 -6.767  -4.926  1.00 42.99  ? 219 PHE A CD2  1 
ATOM   3261 C CE1  . PHE A 1 219 ? -15.020 -5.657  -3.968  1.00 46.07  ? 219 PHE A CE1  1 
ATOM   3262 C CE2  . PHE A 1 219 ? -12.951 -5.429  -5.137  1.00 41.63  ? 219 PHE A CE2  1 
ATOM   3263 C CZ   . PHE A 1 219 ? -14.117 -4.873  -4.656  1.00 41.21  ? 219 PHE A CZ   1 
ATOM   3264 H H    . PHE A 1 219 ? -13.519 -8.682  -6.473  1.00 52.94  ? 219 PHE A H    1 
ATOM   3265 H HA   . PHE A 1 219 ? -13.640 -10.844 -4.904  1.00 53.62  ? 219 PHE A HA   1 
ATOM   3266 H HB2  . PHE A 1 219 ? -13.605 -9.256  -3.130  1.00 46.34  ? 219 PHE A HB2  1 
ATOM   3267 H HB3  . PHE A 1 219 ? -12.336 -9.148  -4.080  1.00 46.34  ? 219 PHE A HB3  1 
ATOM   3268 H HD1  . PHE A 1 219 ? -15.365 -7.519  -3.298  1.00 47.93  ? 219 PHE A HD1  1 
ATOM   3269 H HD2  . PHE A 1 219 ? -11.900 -7.137  -5.252  1.00 51.64  ? 219 PHE A HD2  1 
ATOM   3270 H HE1  . PHE A 1 219 ? -15.807 -5.285  -3.644  1.00 55.34  ? 219 PHE A HE1  1 
ATOM   3271 H HE2  . PHE A 1 219 ? -12.341 -4.903  -5.602  1.00 50.01  ? 219 PHE A HE2  1 
ATOM   3272 H HZ   . PHE A 1 219 ? -14.295 -3.971  -4.796  1.00 49.51  ? 219 PHE A HZ   1 
ATOM   3273 N N    . LEU A 1 220 ? -16.295 -9.558  -5.730  1.00 42.50  ? 220 LEU A N    1 
ATOM   3274 C CA   . LEU A 1 220 ? -17.738 -9.603  -5.556  1.00 44.60  ? 220 LEU A CA   1 
ATOM   3275 C C    . LEU A 1 220 ? -18.238 -11.039 -5.666  1.00 48.25  ? 220 LEU A C    1 
ATOM   3276 O O    . LEU A 1 220 ? -17.604 -11.899 -6.283  1.00 47.90  ? 220 LEU A O    1 
ATOM   3277 C CB   . LEU A 1 220 ? -18.423 -8.719  -6.599  1.00 45.18  ? 220 LEU A CB   1 
ATOM   3278 C CG   . LEU A 1 220 ? -18.122 -7.222  -6.496  1.00 44.80  ? 220 LEU A CG   1 
ATOM   3279 C CD1  . LEU A 1 220 ? -18.675 -6.455  -7.685  1.00 40.27  ? 220 LEU A CD1  1 
ATOM   3280 C CD2  . LEU A 1 220 ? -18.687 -6.663  -5.198  1.00 45.83  ? 220 LEU A CD2  1 
ATOM   3281 H H    . LEU A 1 220 ? -16.039 -9.252  -6.492  1.00 51.05  ? 220 LEU A H    1 
ATOM   3282 H HA   . LEU A 1 220 ? -17.977 -9.267  -4.678  1.00 53.58  ? 220 LEU A HA   1 
ATOM   3283 H HB2  . LEU A 1 220 ? -18.138 -9.011  -7.479  1.00 54.27  ? 220 LEU A HB2  1 
ATOM   3284 H HB3  . LEU A 1 220 ? -19.382 -8.828  -6.507  1.00 54.27  ? 220 LEU A HB3  1 
ATOM   3285 H HG   . LEU A 1 220 ? -17.159 -7.103  -6.499  1.00 53.82  ? 220 LEU A HG   1 
ATOM   3286 H HD11 . LEU A 1 220 ? -18.458 -5.515  -7.583  1.00 48.38  ? 220 LEU A HD11 1 
ATOM   3287 H HD12 . LEU A 1 220 ? -18.275 -6.801  -8.498  1.00 48.38  ? 220 LEU A HD12 1 
ATOM   3288 H HD13 . LEU A 1 220 ? -19.638 -6.571  -7.715  1.00 48.38  ? 220 LEU A HD13 1 
ATOM   3289 H HD21 . LEU A 1 220 ? -18.601 -5.697  -5.207  1.00 55.05  ? 220 LEU A HD21 1 
ATOM   3290 H HD22 . LEU A 1 220 ? -19.622 -6.912  -5.128  1.00 55.05  ? 220 LEU A HD22 1 
ATOM   3291 H HD23 . LEU A 1 220 ? -18.189 -7.032  -4.452  1.00 55.05  ? 220 LEU A HD23 1 
ATOM   3292 N N    . ASN A 1 221 ? -19.382 -11.296 -5.039  1.00 52.00  ? 221 ASN A N    1 
ATOM   3293 C CA   . ASN A 1 221 ? -20.055 -12.581 -5.140  1.00 51.63  ? 221 ASN A CA   1 
ATOM   3294 C C    . ASN A 1 221 ? -21.555 -12.334 -5.119  1.00 58.24  ? 221 ASN A C    1 
ATOM   3295 O O    . ASN A 1 221 ? -22.020 -11.216 -4.881  1.00 47.68  ? 221 ASN A O    1 
ATOM   3296 C CB   . ASN A 1 221 ? -19.646 -13.531 -4.008  1.00 62.03  ? 221 ASN A CB   1 
ATOM   3297 C CG   . ASN A 1 221 ? -19.714 -12.877 -2.648  1.00 63.61  ? 221 ASN A CG   1 
ATOM   3298 O OD1  . ASN A 1 221 ? -20.781 -12.452 -2.204  1.00 66.46  ? 221 ASN A OD1  1 
ATOM   3299 N ND2  . ASN A 1 221 ? -18.574 -12.791 -1.976  1.00 62.32  ? 221 ASN A ND2  1 
ATOM   3300 H H    . ASN A 1 221 ? -19.794 -10.730 -4.540  1.00 62.46  ? 221 ASN A H    1 
ATOM   3301 H HA   . ASN A 1 221 ? -19.818 -13.006 -5.979  1.00 62.02  ? 221 ASN A HA   1 
ATOM   3302 H HB2  . ASN A 1 221 ? -20.244 -14.295 -4.005  1.00 74.50  ? 221 ASN A HB2  1 
ATOM   3303 H HB3  . ASN A 1 221 ? -18.734 -13.825 -4.155  1.00 74.50  ? 221 ASN A HB3  1 
ATOM   3304 H HD21 . ASN A 1 221 ? -18.560 -12.427 -1.197  1.00 74.84  ? 221 ASN A HD21 1 
ATOM   3305 H HD22 . ASN A 1 221 ? -17.848 -13.100 -2.319  1.00 74.84  ? 221 ASN A HD22 1 
ATOM   3306 N N    . ARG A 1 222 ? -22.313 -13.397 -5.374  1.00 61.54  ? 222 ARG A N    1 
ATOM   3307 C CA   . ARG A 1 222 ? -23.768 -13.330 -5.376  1.00 66.46  ? 222 ARG A CA   1 
ATOM   3308 C C    . ARG A 1 222 ? -24.368 -13.454 -3.982  1.00 67.77  ? 222 ARG A C    1 
ATOM   3309 O O    . ARG A 1 222 ? -25.593 -13.356 -3.843  1.00 69.12  ? 222 ARG A O    1 
ATOM   3310 C CB   . ARG A 1 222 ? -24.339 -14.438 -6.267  1.00 66.99  ? 222 ARG A CB   1 
ATOM   3311 C CG   . ARG A 1 222 ? -24.299 -15.816 -5.617  1.00 71.79  ? 222 ARG A CG   1 
ATOM   3312 C CD   . ARG A 1 222 ? -24.677 -16.925 -6.588  1.00 72.91  ? 222 ARG A CD   1 
ATOM   3313 N NE   . ARG A 1 222 ? -24.083 -18.200 -6.201  1.00 74.62  ? 222 ARG A NE   1 
ATOM   3314 C CZ   . ARG A 1 222 ? -24.645 -19.072 -5.374  1.00 91.01  ? 222 ARG A CZ   1 
ATOM   3315 N NH1  . ARG A 1 222 ? -25.834 -18.851 -4.837  1.00 92.96  ? 222 ARG A NH1  1 
ATOM   3316 N NH2  . ARG A 1 222 ? -23.998 -20.196 -5.080  1.00 84.83  ? 222 ARG A NH2  1 
ATOM   3317 H H    . ARG A 1 222 ? -22.003 -14.179 -5.553  1.00 73.91  ? 222 ARG A H    1 
ATOM   3318 H HA   . ARG A 1 222 ? -24.035 -12.473 -5.743  1.00 79.81  ? 222 ARG A HA   1 
ATOM   3319 H HB2  . ARG A 1 222 ? -25.265 -14.231 -6.469  1.00 80.44  ? 222 ARG A HB2  1 
ATOM   3320 H HB3  . ARG A 1 222 ? -23.821 -14.480 -7.086  1.00 80.44  ? 222 ARG A HB3  1 
ATOM   3321 H HG2  . ARG A 1 222 ? -23.400 -15.990 -5.296  1.00 86.21  ? 222 ARG A HG2  1 
ATOM   3322 H HG3  . ARG A 1 222 ? -24.925 -15.837 -4.877  1.00 86.21  ? 222 ARG A HG3  1 
ATOM   3323 H HD2  . ARG A 1 222 ? -25.641 -17.028 -6.598  1.00 87.55  ? 222 ARG A HD2  1 
ATOM   3324 H HD3  . ARG A 1 222 ? -24.359 -16.697 -7.476  1.00 87.55  ? 222 ARG A HD3  1 
ATOM   3325 H HE   . ARG A 1 222 ? -23.314 -18.399 -6.531  1.00 89.60  ? 222 ARG A HE   1 
ATOM   3326 H HH11 . ARG A 1 222 ? -26.260 -18.127 -5.020  1.00 111.60 ? 222 ARG A HH11 1 
ATOM   3327 H HH12 . ARG A 1 222 ? -26.179 -19.430 -4.304  1.00 111.60 ? 222 ARG A HH12 1 
ATOM   3328 H HH21 . ARG A 1 222 ? -23.226 -20.351 -5.425  1.00 101.85 ? 222 ARG A HH21 1 
ATOM   3329 H HH22 . ARG A 1 222 ? -24.353 -20.769 -4.546  1.00 101.85 ? 222 ARG A HH22 1 
ATOM   3330 N N    . PHE A 1 223 ? -23.547 -13.665 -2.959  1.00 74.25  ? 223 PHE A N    1 
ATOM   3331 C CA   . PHE A 1 223 ? -24.045 -13.967 -1.629  1.00 68.88  ? 223 PHE A CA   1 
ATOM   3332 C C    . PHE A 1 223 ? -24.334 -12.692 -0.840  1.00 67.03  ? 223 PHE A C    1 
ATOM   3333 O O    . PHE A 1 223 ? -23.929 -11.585 -1.204  1.00 60.84  ? 223 PHE A O    1 
ATOM   3334 C CB   . PHE A 1 223 ? -23.042 -14.830 -0.861  1.00 69.65  ? 223 PHE A CB   1 
ATOM   3335 C CG   . PHE A 1 223 ? -22.970 -16.253 -1.339  1.00 88.12  ? 223 PHE A CG   1 
ATOM   3336 C CD1  . PHE A 1 223 ? -21.759 -16.924 -1.369  1.00 89.81  ? 223 PHE A CD1  1 
ATOM   3337 C CD2  . PHE A 1 223 ? -24.109 -16.920 -1.754  1.00 78.79  ? 223 PHE A CD2  1 
ATOM   3338 C CE1  . PHE A 1 223 ? -21.687 -18.231 -1.808  1.00 87.43  ? 223 PHE A CE1  1 
ATOM   3339 C CE2  . PHE A 1 223 ? -24.045 -18.227 -2.195  1.00 86.83  ? 223 PHE A CE2  1 
ATOM   3340 C CZ   . PHE A 1 223 ? -22.832 -18.884 -2.221  1.00 93.97  ? 223 PHE A CZ   1 
ATOM   3341 H H    . PHE A 1 223 ? -22.689 -13.637 -3.014  1.00 89.15  ? 223 PHE A H    1 
ATOM   3342 H HA   . PHE A 1 223 ? -24.874 -14.461 -1.723  1.00 82.71  ? 223 PHE A HA   1 
ATOM   3343 H HB2  . PHE A 1 223 ? -22.158 -14.441 -0.958  1.00 83.64  ? 223 PHE A HB2  1 
ATOM   3344 H HB3  . PHE A 1 223 ? -23.297 -14.845 0.074   1.00 83.64  ? 223 PHE A HB3  1 
ATOM   3345 H HD1  . PHE A 1 223 ? -20.985 -16.489 -1.090  1.00 107.83 ? 223 PHE A HD1  1 
ATOM   3346 H HD2  . PHE A 1 223 ? -24.930 -16.483 -1.735  1.00 94.60  ? 223 PHE A HD2  1 
ATOM   3347 H HE1  . PHE A 1 223 ? -20.868 -18.672 -1.825  1.00 104.97 ? 223 PHE A HE1  1 
ATOM   3348 H HE2  . PHE A 1 223 ? -24.818 -18.663 -2.473  1.00 104.25 ? 223 PHE A HE2  1 
ATOM   3349 H HZ   . PHE A 1 223 ? -22.786 -19.765 -2.517  1.00 112.82 ? 223 PHE A HZ   1 
ATOM   3350 N N    . THR A 1 224 ? -25.054 -12.873 0.263   1.00 76.46  ? 224 THR A N    1 
ATOM   3351 C CA   . THR A 1 224 ? -25.347 -11.810 1.208   1.00 70.57  ? 224 THR A CA   1 
ATOM   3352 C C    . THR A 1 224 ? -25.197 -12.381 2.610   1.00 67.88  ? 224 THR A C    1 
ATOM   3353 O O    . THR A 1 224 ? -25.046 -13.593 2.797   1.00 72.70  ? 224 THR A O    1 
ATOM   3354 C CB   . THR A 1 224 ? -26.752 -11.238 0.998   1.00 66.17  ? 224 THR A CB   1 
ATOM   3355 O OG1  . THR A 1 224 ? -26.923 -10.074 1.816   1.00 75.05  ? 224 THR A OG1  1 
ATOM   3356 C CG2  . THR A 1 224 ? -27.806 -12.273 1.358   1.00 71.08  ? 224 THR A CG2  1 
ATOM   3357 H H    . THR A 1 224 ? -25.393 -13.629 0.490   1.00 91.81  ? 224 THR A H    1 
ATOM   3358 H HA   . THR A 1 224 ? -24.716 -11.081 1.095   1.00 84.74  ? 224 THR A HA   1 
ATOM   3359 H HB   . THR A 1 224 ? -26.870 -10.995 0.067   1.00 79.46  ? 224 THR A HB   1 
ATOM   3360 H HG1  . THR A 1 224 ? -27.686 -9.746  1.693   1.00 90.12  ? 224 THR A HG1  1 
ATOM   3361 H HG21 . THR A 1 224 ? -28.673 -11.994 1.023   1.00 85.36  ? 224 THR A HG21 1 
ATOM   3362 H HG22 . THR A 1 224 ? -27.578 -13.130 0.964   1.00 85.36  ? 224 THR A HG22 1 
ATOM   3363 H HG23 . THR A 1 224 ? -27.858 -12.373 2.321   1.00 85.36  ? 224 THR A HG23 1 
ATOM   3364 N N    . THR A 1 225 ? -25.244 -11.496 3.600   1.00 61.52  ? 225 THR A N    1 
ATOM   3365 C CA   . THR A 1 225 ? -25.120 -11.896 4.991   1.00 67.49  ? 225 THR A CA   1 
ATOM   3366 C C    . THR A 1 225 ? -25.957 -10.947 5.837   1.00 64.95  ? 225 THR A C    1 
ATOM   3367 O O    . THR A 1 225 ? -26.432 -9.912  5.363   1.00 62.27  ? 225 THR A O    1 
ATOM   3368 C CB   . THR A 1 225 ? -23.651 -11.901 5.441   1.00 64.93  ? 225 THR A CB   1 
ATOM   3369 O OG1  . THR A 1 225 ? -23.559 -12.334 6.805   1.00 75.40  ? 225 THR A OG1  1 
ATOM   3370 C CG2  . THR A 1 225 ? -23.038 -10.511 5.305   1.00 56.89  ? 225 THR A CG2  1 
ATOM   3371 H H    . THR A 1 225 ? -25.349 -10.650 3.488   1.00 73.88  ? 225 THR A H    1 
ATOM   3372 H HA   . THR A 1 225 ? -25.469 -12.793 5.108   1.00 81.04  ? 225 THR A HA   1 
ATOM   3373 H HB   . THR A 1 225 ? -23.149 -12.510 4.878   1.00 77.98  ? 225 THR A HB   1 
ATOM   3374 H HG1  . THR A 1 225 ? -23.770 -11.705 7.321   1.00 90.54  ? 225 THR A HG1  1 
ATOM   3375 H HG21 . THR A 1 225 ? -22.112 -10.527 5.595   1.00 68.32  ? 225 THR A HG21 1 
ATOM   3376 H HG22 . THR A 1 225 ? -23.074 -10.222 4.380   1.00 68.32  ? 225 THR A HG22 1 
ATOM   3377 H HG23 . THR A 1 225 ? -23.528 -9.877  5.852   1.00 68.32  ? 225 THR A HG23 1 
ATOM   3378 N N    . THR A 1 226 ? -26.160 -11.328 7.093   1.00 70.08  ? 226 THR A N    1 
ATOM   3379 C CA   . THR A 1 226 ? -26.823 -10.466 8.058   1.00 61.07  ? 226 THR A CA   1 
ATOM   3380 C C    . THR A 1 226 ? -25.773 -9.672  8.829   1.00 58.14  ? 226 THR A C    1 
ATOM   3381 O O    . THR A 1 226 ? -24.607 -10.064 8.923   1.00 54.33  ? 226 THR A O    1 
ATOM   3382 C CB   . THR A 1 226 ? -27.690 -11.277 9.023   1.00 73.49  ? 226 THR A CB   1 
ATOM   3383 O OG1  . THR A 1 226 ? -26.908 -12.305 9.643   1.00 62.11  ? 226 THR A OG1  1 
ATOM   3384 C CG2  . THR A 1 226 ? -28.863 -11.910 8.277   1.00 104.89 ? 226 THR A CG2  1 
ATOM   3385 H H    . THR A 1 226 ? -25.919 -12.089 7.412   1.00 84.15  ? 226 THR A H    1 
ATOM   3386 H HA   . THR A 1 226 ? -27.413 -9.849  7.596   1.00 73.34  ? 226 THR A HA   1 
ATOM   3387 H HB   . THR A 1 226 ? -28.040 -10.690 9.711   1.00 88.25  ? 226 THR A HB   1 
ATOM   3388 H HG1  . THR A 1 226 ? -27.366 -12.702 10.225  1.00 74.59  ? 226 THR A HG1  1 
ATOM   3389 H HG21 . THR A 1 226 ? -29.427 -12.397 8.898   1.00 125.93 ? 226 THR A HG21 1 
ATOM   3390 H HG22 . THR A 1 226 ? -29.391 -11.221 7.845   1.00 125.93 ? 226 THR A HG22 1 
ATOM   3391 H HG23 . THR A 1 226 ? -28.534 -12.524 7.602   1.00 125.93 ? 226 THR A HG23 1 
ATOM   3392 N N    . LEU A 1 227 ? -26.195 -8.526  9.365   1.00 53.50  ? 227 LEU A N    1 
ATOM   3393 C CA   . LEU A 1 227 ? -25.278 -7.725  10.169  1.00 57.35  ? 227 LEU A CA   1 
ATOM   3394 C C    . LEU A 1 227 ? -24.746 -8.530  11.347  1.00 56.31  ? 227 LEU A C    1 
ATOM   3395 O O    . LEU A 1 227 ? -23.597 -8.337  11.764  1.00 57.72  ? 227 LEU A O    1 
ATOM   3396 C CB   . LEU A 1 227 ? -25.978 -6.452  10.643  1.00 51.82  ? 227 LEU A CB   1 
ATOM   3397 C CG   . LEU A 1 227 ? -25.086 -5.312  11.137  1.00 46.66  ? 227 LEU A CG   1 
ATOM   3398 C CD1  . LEU A 1 227 ? -24.016 -4.966  10.121  1.00 61.82  ? 227 LEU A CD1  1 
ATOM   3399 C CD2  . LEU A 1 227 ? -25.916 -4.075  11.455  1.00 59.27  ? 227 LEU A CD2  1 
ATOM   3400 H H    . LEU A 1 227 ? -26.986 -8.199  9.280   1.00 64.26  ? 227 LEU A H    1 
ATOM   3401 H HA   . LEU A 1 227 ? -24.521 -7.453  9.627   1.00 68.87  ? 227 LEU A HA   1 
ATOM   3402 H HB2  . LEU A 1 227 ? -26.498 -6.104  9.902   1.00 62.24  ? 227 LEU A HB2  1 
ATOM   3403 H HB3  . LEU A 1 227 ? -26.565 -6.691  11.378  1.00 62.24  ? 227 LEU A HB3  1 
ATOM   3404 H HG   . LEU A 1 227 ? -24.646 -5.608  11.949  1.00 56.05  ? 227 LEU A HG   1 
ATOM   3405 H HD11 . LEU A 1 227 ? -23.494 -4.220  10.454  1.00 74.24  ? 227 LEU A HD11 1 
ATOM   3406 H HD12 . LEU A 1 227 ? -23.443 -5.738  9.991   1.00 74.24  ? 227 LEU A HD12 1 
ATOM   3407 H HD13 . LEU A 1 227 ? -24.442 -4.725  9.284   1.00 74.24  ? 227 LEU A HD13 1 
ATOM   3408 H HD21 . LEU A 1 227 ? -25.324 -3.363  11.743  1.00 71.18  ? 227 LEU A HD21 1 
ATOM   3409 H HD22 . LEU A 1 227 ? -26.396 -3.804  10.657  1.00 71.18  ? 227 LEU A HD22 1 
ATOM   3410 H HD23 . LEU A 1 227 ? -26.545 -4.290  12.162  1.00 71.18  ? 227 LEU A HD23 1 
ATOM   3411 N N    . ASN A 1 228 ? -25.555 -9.459  11.868  1.00 54.67  ? 228 ASN A N    1 
ATOM   3412 C CA   . ASN A 1 228 ? -25.145 -10.254 13.022  1.00 63.73  ? 228 ASN A CA   1 
ATOM   3413 C C    . ASN A 1 228 ? -24.087 -11.282 12.638  1.00 56.59  ? 228 ASN A C    1 
ATOM   3414 O O    . ASN A 1 228 ? -23.053 -11.408 13.306  1.00 61.97  ? 228 ASN A O    1 
ATOM   3415 C CB   . ASN A 1 228 ? -26.364 -10.945 13.633  1.00 66.13  ? 228 ASN A CB   1 
ATOM   3416 C CG   . ASN A 1 228 ? -27.192 -10.013 14.495  1.00 77.70  ? 228 ASN A CG   1 
ATOM   3417 O OD1  . ASN A 1 228 ? -26.716 -8.963  14.926  1.00 70.60  ? 228 ASN A OD1  1 
ATOM   3418 N ND2  . ASN A 1 228 ? -28.440 -10.390 14.749  1.00 75.26  ? 228 ASN A ND2  1 
ATOM   3419 H H    . ASN A 1 228 ? -26.341 -9.645  11.572  1.00 65.66  ? 228 ASN A H    1 
ATOM   3420 H HA   . ASN A 1 228 ? -24.760 -9.662  13.688  1.00 76.53  ? 228 ASN A HA   1 
ATOM   3421 H HB2  . ASN A 1 228 ? -26.931 -11.276 12.919  1.00 79.42  ? 228 ASN A HB2  1 
ATOM   3422 H HB3  . ASN A 1 228 ? -26.065 -11.682 14.188  1.00 79.42  ? 228 ASN A HB3  1 
ATOM   3423 H HD21 . ASN A 1 228 ? -28.739 -11.130 14.429  1.00 90.37  ? 228 ASN A HD21 1 
ATOM   3424 H HD22 . ASN A 1 228 ? -28.949 -9.894  15.234  1.00 90.37  ? 228 ASN A HD22 1 
ATOM   3425 N N    . ASP A 1 229 ? -24.338 -12.048 11.572  1.00 62.62  ? 229 ASP A N    1 
ATOM   3426 C CA   . ASP A 1 229 ? -23.364 -13.050 11.151  1.00 66.61  ? 229 ASP A CA   1 
ATOM   3427 C C    . ASP A 1 229 ? -22.073 -12.400 10.676  1.00 64.51  ? 229 ASP A C    1 
ATOM   3428 O O    . ASP A 1 229 ? -20.985 -12.958 10.875  1.00 57.84  ? 229 ASP A O    1 
ATOM   3429 C CB   . ASP A 1 229 ? -23.954 -13.934 10.052  1.00 71.18  ? 229 ASP A CB   1 
ATOM   3430 C CG   . ASP A 1 229 ? -25.084 -14.813 10.557  1.00 75.04  ? 229 ASP A CG   1 
ATOM   3431 O OD1  . ASP A 1 229 ? -25.208 -14.987 11.790  1.00 67.76  ? 229 ASP A OD1  1 
ATOM   3432 O OD2  . ASP A 1 229 ? -25.855 -15.333 9.721   1.00 74.88  ? 229 ASP A OD2  1 
ATOM   3433 H H    . ASP A 1 229 ? -25.048 -12.006 11.089  1.00 75.20  ? 229 ASP A H    1 
ATOM   3434 H HA   . ASP A 1 229 ? -23.156 -13.622 11.907  1.00 79.99  ? 229 ASP A HA   1 
ATOM   3435 H HB2  . ASP A 1 229 ? -24.304 -13.370 9.345   1.00 85.47  ? 229 ASP A HB2  1 
ATOM   3436 H HB3  . ASP A 1 229 ? -23.257 -14.511 9.702   1.00 85.47  ? 229 ASP A HB3  1 
ATOM   3437 N N    . PHE A 1 230 ? -22.166 -11.223 10.052  1.00 62.77  ? 230 PHE A N    1 
ATOM   3438 C CA   . PHE A 1 230 ? -20.954 -10.522 9.649   1.00 64.31  ? 230 PHE A CA   1 
ATOM   3439 C C    . PHE A 1 230 ? -20.130 -10.121 10.868  1.00 55.09  ? 230 PHE A C    1 
ATOM   3440 O O    . PHE A 1 230 ? -18.913 -10.339 10.916  1.00 54.23  ? 230 PHE A O    1 
ATOM   3441 C CB   . PHE A 1 230 ? -21.286 -9.282  8.823   1.00 59.09  ? 230 PHE A CB   1 
ATOM   3442 C CG   . PHE A 1 230 ? -20.085 -8.430  8.543   1.00 66.11  ? 230 PHE A CG   1 
ATOM   3443 C CD1  . PHE A 1 230 ? -19.083 -8.890  7.706   1.00 60.66  ? 230 PHE A CD1  1 
ATOM   3444 C CD2  . PHE A 1 230 ? -19.932 -7.194  9.147   1.00 68.83  ? 230 PHE A CD2  1 
ATOM   3445 C CE1  . PHE A 1 230 ? -17.962 -8.125  7.455   1.00 60.02  ? 230 PHE A CE1  1 
ATOM   3446 C CE2  . PHE A 1 230 ? -18.811 -6.422  8.900   1.00 62.10  ? 230 PHE A CE2  1 
ATOM   3447 C CZ   . PHE A 1 230 ? -17.825 -6.890  8.054   1.00 60.63  ? 230 PHE A CZ   1 
ATOM   3448 H H    . PHE A 1 230 ? -22.902 -10.823 9.857   1.00 75.38  ? 230 PHE A H    1 
ATOM   3449 H HA   . PHE A 1 230 ? -20.433 -11.121 9.093   1.00 77.23  ? 230 PHE A HA   1 
ATOM   3450 H HB2  . PHE A 1 230 ? -21.660 -9.561  7.973   1.00 70.97  ? 230 PHE A HB2  1 
ATOM   3451 H HB3  . PHE A 1 230 ? -21.930 -8.743  9.308   1.00 70.97  ? 230 PHE A HB3  1 
ATOM   3452 H HD1  . PHE A 1 230 ? -19.166 -9.727  7.308   1.00 72.85  ? 230 PHE A HD1  1 
ATOM   3453 H HD2  . PHE A 1 230 ? -20.589 -6.880  9.725   1.00 82.65  ? 230 PHE A HD2  1 
ATOM   3454 H HE1  . PHE A 1 230 ? -17.301 -8.441  6.883   1.00 72.08  ? 230 PHE A HE1  1 
ATOM   3455 H HE2  . PHE A 1 230 ? -18.722 -5.589  9.304   1.00 74.57  ? 230 PHE A HE2  1 
ATOM   3456 H HZ   . PHE A 1 230 ? -17.070 -6.373  7.889   1.00 72.81  ? 230 PHE A HZ   1 
ATOM   3457 N N    . ASN A 1 231 ? -20.788 -9.531  11.871  1.00 52.17  ? 231 ASN A N    1 
ATOM   3458 C CA   . ASN A 1 231 ? -20.069 -9.041  13.044  1.00 47.92  ? 231 ASN A CA   1 
ATOM   3459 C C    . ASN A 1 231 ? -19.393 -10.174 13.806  1.00 53.98  ? 231 ASN A C    1 
ATOM   3460 O O    . ASN A 1 231 ? -18.386 -9.951  14.488  1.00 55.63  ? 231 ASN A O    1 
ATOM   3461 C CB   . ASN A 1 231 ? -21.025 -8.272  13.952  1.00 46.21  ? 231 ASN A CB   1 
ATOM   3462 C CG   . ASN A 1 231 ? -21.213 -6.839  13.504  1.00 51.04  ? 231 ASN A CG   1 
ATOM   3463 O OD1  . ASN A 1 231 ? -20.353 -6.275  12.831  1.00 56.78  ? 231 ASN A OD1  1 
ATOM   3464 N ND2  . ASN A 1 231 ? -22.342 -6.242  13.869  1.00 56.94  ? 231 ASN A ND2  1 
ATOM   3465 H H    . ASN A 1 231 ? -21.638 -9.404  11.895  1.00 62.66  ? 231 ASN A H    1 
ATOM   3466 H HA   . ASN A 1 231 ? -19.374 -8.430  12.755  1.00 57.56  ? 231 ASN A HA   1 
ATOM   3467 H HB2  . ASN A 1 231 ? -21.892 -8.708  13.942  1.00 55.51  ? 231 ASN A HB2  1 
ATOM   3468 H HB3  . ASN A 1 231 ? -20.669 -8.263  14.854  1.00 55.51  ? 231 ASN A HB3  1 
ATOM   3469 H HD21 . ASN A 1 231 ? -22.492 -5.428  13.637  1.00 68.38  ? 231 ASN A HD21 1 
ATOM   3470 H HD22 . ASN A 1 231 ? -22.923 -6.670  14.337  1.00 68.38  ? 231 ASN A HD22 1 
ATOM   3471 N N    . LEU A 1 232 ? -19.924 -11.394 13.711  1.00 53.49  ? 232 LEU A N    1 
ATOM   3472 C CA   . LEU A 1 232 ? -19.240 -12.527 14.326  1.00 55.75  ? 232 LEU A CA   1 
ATOM   3473 C C    . LEU A 1 232 ? -17.890 -12.770 13.661  1.00 56.39  ? 232 LEU A C    1 
ATOM   3474 O O    . LEU A 1 232 ? -16.889 -13.032 14.338  1.00 59.62  ? 232 LEU A O    1 
ATOM   3475 C CB   . LEU A 1 232 ? -20.107 -13.780 14.242  1.00 53.86  ? 232 LEU A CB   1 
ATOM   3476 C CG   . LEU A 1 232 ? -21.238 -13.856 15.266  1.00 60.94  ? 232 LEU A CG   1 
ATOM   3477 C CD1  . LEU A 1 232 ? -22.188 -14.986 14.901  1.00 57.44  ? 232 LEU A CD1  1 
ATOM   3478 C CD2  . LEU A 1 232 ? -20.690 -14.034 16.675  1.00 62.22  ? 232 LEU A CD2  1 
ATOM   3479 H H    . LEU A 1 232 ? -20.659 -11.586 13.308  1.00 64.25  ? 232 LEU A H    1 
ATOM   3480 H HA   . LEU A 1 232 ? -19.091 -12.332 15.264  1.00 66.95  ? 232 LEU A HA   1 
ATOM   3481 H HB2  . LEU A 1 232 ? -20.509 -13.815 13.361  1.00 64.69  ? 232 LEU A HB2  1 
ATOM   3482 H HB3  . LEU A 1 232 ? -19.539 -14.555 14.378  1.00 64.69  ? 232 LEU A HB3  1 
ATOM   3483 H HG   . LEU A 1 232 ? -21.734 -13.022 15.257  1.00 73.19  ? 232 LEU A HG   1 
ATOM   3484 H HD11 . LEU A 1 232 ? -22.901 -15.024 15.559  1.00 68.98  ? 232 LEU A HD11 1 
ATOM   3485 H HD12 . LEU A 1 232 ? -22.559 -14.815 14.021  1.00 68.98  ? 232 LEU A HD12 1 
ATOM   3486 H HD13 . LEU A 1 232 ? -21.697 -15.822 14.897  1.00 68.98  ? 232 LEU A HD13 1 
ATOM   3487 H HD21 . LEU A 1 232 ? -21.426 -14.219 17.279  1.00 74.73  ? 232 LEU A HD21 1 
ATOM   3488 H HD22 . LEU A 1 232 ? -20.065 -14.776 16.679  1.00 74.73  ? 232 LEU A HD22 1 
ATOM   3489 H HD23 . LEU A 1 232 ? -20.238 -13.219 16.944  1.00 74.73  ? 232 LEU A HD23 1 
ATOM   3490 N N    . VAL A 1 233 ? -17.845 -12.680 12.330  1.00 60.22  ? 233 VAL A N    1 
ATOM   3491 C CA   . VAL A 1 233 ? -16.586 -12.867 11.617  1.00 54.47  ? 233 VAL A CA   1 
ATOM   3492 C C    . VAL A 1 233 ? -15.647 -11.697 11.879  1.00 52.27  ? 233 VAL A C    1 
ATOM   3493 O O    . VAL A 1 233 ? -14.425 -11.871 11.963  1.00 55.20  ? 233 VAL A O    1 
ATOM   3494 C CB   . VAL A 1 233 ? -16.850 -13.056 10.111  1.00 64.77  ? 233 VAL A CB   1 
ATOM   3495 C CG1  . VAL A 1 233 ? -15.544 -13.003 9.332   1.00 66.44  ? 233 VAL A CG1  1 
ATOM   3496 C CG2  . VAL A 1 233 ? -17.586 -14.365 9.869   1.00 60.33  ? 233 VAL A CG2  1 
ATOM   3497 H H    . VAL A 1 233 ? -18.521 -12.515 11.825  1.00 72.32  ? 233 VAL A H    1 
ATOM   3498 H HA   . VAL A 1 233 ? -16.160 -13.672 11.951  1.00 65.42  ? 233 VAL A HA   1 
ATOM   3499 H HB   . VAL A 1 233 ? -17.412 -12.334 9.790   1.00 77.78  ? 233 VAL A HB   1 
ATOM   3500 H HG11 . VAL A 1 233 ? -15.685 -13.386 8.452   1.00 79.79  ? 233 VAL A HG11 1 
ATOM   3501 H HG12 . VAL A 1 233 ? -15.263 -12.078 9.249   1.00 79.79  ? 233 VAL A HG12 1 
ATOM   3502 H HG13 . VAL A 1 233 ? -14.870 -13.511 9.810   1.00 79.79  ? 233 VAL A HG13 1 
ATOM   3503 H HG21 . VAL A 1 233 ? -17.721 -14.479 8.915   1.00 72.45  ? 233 VAL A HG21 1 
ATOM   3504 H HG22 . VAL A 1 233 ? -17.053 -15.096 10.217  1.00 72.45  ? 233 VAL A HG22 1 
ATOM   3505 H HG23 . VAL A 1 233 ? -18.442 -14.334 10.323  1.00 72.45  ? 233 VAL A HG23 1 
ATOM   3506 N N    . ALA A 1 234 ? -16.196 -10.486 12.004  1.00 56.91  ? 234 ALA A N    1 
ATOM   3507 C CA   . ALA A 1 234 ? -15.365 -9.325  12.304  1.00 61.14  ? 234 ALA A CA   1 
ATOM   3508 C C    . ALA A 1 234 ? -14.627 -9.513  13.622  1.00 60.70  ? 234 ALA A C    1 
ATOM   3509 O O    . ALA A 1 234 ? -13.399 -9.379  13.684  1.00 53.87  ? 234 ALA A O    1 
ATOM   3510 C CB   . ALA A 1 234 ? -16.225 -8.061  12.343  1.00 56.10  ? 234 ALA A CB   1 
ATOM   3511 H H    . ALA A 1 234 ? -17.035 -10.315 11.921  1.00 68.35  ? 234 ALA A H    1 
ATOM   3512 H HA   . ALA A 1 234 ? -14.707 -9.219  11.599  1.00 73.42  ? 234 ALA A HA   1 
ATOM   3513 H HB1  . ALA A 1 234 ? -15.657 -7.299  12.537  1.00 67.38  ? 234 ALA A HB1  1 
ATOM   3514 H HB2  . ALA A 1 234 ? -16.653 -7.943  11.480  1.00 67.38  ? 234 ALA A HB2  1 
ATOM   3515 H HB3  . ALA A 1 234 ? -16.897 -8.158  13.035  1.00 67.38  ? 234 ALA A HB3  1 
ATOM   3516 N N    . MET A 1 235 ? -15.367 -9.821  14.693  1.00 60.09  ? 235 MET A N    1 
ATOM   3517 C CA   . MET A 1 235 ? -14.747 -10.049 15.994  1.00 71.52  ? 235 MET A CA   1 
ATOM   3518 C C    . MET A 1 235 ? -13.550 -10.985 15.889  1.00 65.49  ? 235 MET A C    1 
ATOM   3519 O O    . MET A 1 235 ? -12.569 -10.831 16.627  1.00 65.81  ? 235 MET A O    1 
ATOM   3520 C CB   . MET A 1 235 ? -15.767 -10.646 16.970  1.00 74.95  ? 235 MET A CB   1 
ATOM   3521 C CG   . MET A 1 235 ? -16.553 -9.645  17.801  1.00 91.34  ? 235 MET A CG   1 
ATOM   3522 S SD   . MET A 1 235 ? -17.257 -10.360 19.312  1.00 99.06  ? 235 MET A SD   1 
ATOM   3523 C CE   . MET A 1 235 ? -17.541 -12.066 18.837  1.00 83.32  ? 235 MET A CE   1 
ATOM   3524 H H    . MET A 1 235 ? -16.223 -9.902  14.690  1.00 72.16  ? 235 MET A H    1 
ATOM   3525 H HA   . MET A 1 235 ? -14.456 -9.192  16.341  1.00 85.89  ? 235 MET A HA   1 
ATOM   3526 H HB2  . MET A 1 235 ? -16.409 -11.163 16.460  1.00 90.00  ? 235 MET A HB2  1 
ATOM   3527 H HB3  . MET A 1 235 ? -15.293 -11.224 17.589  1.00 90.00  ? 235 MET A HB3  1 
ATOM   3528 H HG2  . MET A 1 235 ? -15.962 -8.921  18.061  1.00 109.66 ? 235 MET A HG2  1 
ATOM   3529 H HG3  . MET A 1 235 ? -17.285 -9.300  17.266  1.00 109.66 ? 235 MET A HG3  1 
ATOM   3530 H HE1  . MET A 1 235 ? -17.982 -12.529 19.567  1.00 100.04 ? 235 MET A HE1  1 
ATOM   3531 H HE2  . MET A 1 235 ? -18.102 -12.085 18.047  1.00 100.04 ? 235 MET A HE2  1 
ATOM   3532 H HE3  . MET A 1 235 ? -16.688 -12.487 18.647  1.00 100.04 ? 235 MET A HE3  1 
ATOM   3533 N N    . LYS A 1 236 ? -13.613 -11.962 14.983  1.00 60.36  ? 236 LYS A N    1 
ATOM   3534 C CA   . LYS A 1 236 ? -12.589 -12.998 14.934  1.00 55.78  ? 236 LYS A CA   1 
ATOM   3535 C C    . LYS A 1 236 ? -11.293 -12.480 14.325  1.00 56.93  ? 236 LYS A C    1 
ATOM   3536 O O    . LYS A 1 236 ? -10.205 -12.785 14.825  1.00 60.27  ? 236 LYS A O    1 
ATOM   3537 C CB   . LYS A 1 236 ? -13.106 -14.201 14.146  1.00 48.88  ? 236 LYS A CB   1 
ATOM   3538 H H    . LYS A 1 236 ? -14.233 -12.046 14.393  1.00 72.48  ? 236 LYS A H    1 
ATOM   3539 H HA   . LYS A 1 236 ? -12.394 -13.290 15.838  1.00 66.99  ? 236 LYS A HA   1 
ATOM   3540 N N    . TYR A 1 237 ? -11.391 -11.695 13.253  1.00 53.78  ? 237 TYR A N    1 
ATOM   3541 C CA   . TYR A 1 237 ? -10.233 -11.138 12.573  1.00 57.11  ? 237 TYR A CA   1 
ATOM   3542 C C    . TYR A 1 237 ? -9.857  -9.756  13.092  1.00 53.98  ? 237 TYR A C    1 
ATOM   3543 O O    . TYR A 1 237 ? -9.192  -8.993  12.380  1.00 58.89  ? 237 TYR A O    1 
ATOM   3544 C CB   . TYR A 1 237 ? -10.496 -11.094 11.072  1.00 49.99  ? 237 TYR A CB   1 
ATOM   3545 C CG   . TYR A 1 237 ? -10.561 -12.475 10.469  1.00 49.03  ? 237 TYR A CG   1 
ATOM   3546 C CD1  . TYR A 1 237 ? -9.401  -13.154 10.126  1.00 58.96  ? 237 TYR A CD1  1 
ATOM   3547 C CD2  . TYR A 1 237 ? -11.778 -13.112 10.266  1.00 52.05  ? 237 TYR A CD2  1 
ATOM   3548 C CE1  . TYR A 1 237 ? -9.449  -14.420 9.584   1.00 62.09  ? 237 TYR A CE1  1 
ATOM   3549 C CE2  . TYR A 1 237 ? -11.837 -14.381 9.724   1.00 52.21  ? 237 TYR A CE2  1 
ATOM   3550 C CZ   . TYR A 1 237 ? -10.667 -15.030 9.386   1.00 55.31  ? 237 TYR A CZ   1 
ATOM   3551 O OH   . TYR A 1 237 ? -10.712 -16.295 8.846   1.00 71.38  ? 237 TYR A OH   1 
ATOM   3552 H H    . TYR A 1 237 ? -12.139 -11.468 12.895  1.00 64.59  ? 237 TYR A H    1 
ATOM   3553 H HA   . TYR A 1 237 ? -9.470  -11.717 12.726  1.00 68.59  ? 237 TYR A HA   1 
ATOM   3554 H HB2  . TYR A 1 237 ? -11.345 -10.653 10.910  1.00 60.04  ? 237 TYR A HB2  1 
ATOM   3555 H HB3  . TYR A 1 237 ? -9.780  -10.606 10.636  1.00 60.04  ? 237 TYR A HB3  1 
ATOM   3556 H HD1  . TYR A 1 237 ? -8.576  -12.747 10.264  1.00 70.81  ? 237 TYR A HD1  1 
ATOM   3557 H HD2  . TYR A 1 237 ? -12.566 -12.676 10.498  1.00 62.52  ? 237 TYR A HD2  1 
ATOM   3558 H HE1  . TYR A 1 237 ? -8.663  -14.860 9.353   1.00 74.57  ? 237 TYR A HE1  1 
ATOM   3559 H HE2  . TYR A 1 237 ? -12.658 -14.794 9.588   1.00 62.70  ? 237 TYR A HE2  1 
ATOM   3560 H HH   . TYR A 1 237 ? -11.510 -16.543 8.762   1.00 85.72  ? 237 TYR A HH   1 
ATOM   3561 N N    . ASN A 1 238 ? -10.263 -9.425  14.316  1.00 57.74  ? 238 ASN A N    1 
ATOM   3562 C CA   . ASN A 1 238 ? -9.865  -8.182  14.971  1.00 54.58  ? 238 ASN A CA   1 
ATOM   3563 C C    . ASN A 1 238 ? -10.353 -6.963  14.190  1.00 49.98  ? 238 ASN A C    1 
ATOM   3564 O O    . ASN A 1 238 ? -9.619  -5.997  13.970  1.00 45.65  ? 238 ASN A O    1 
ATOM   3565 C CB   . ASN A 1 238 ? -8.349  -8.132  15.167  1.00 61.94  ? 238 ASN A CB   1 
ATOM   3566 C CG   . ASN A 1 238 ? -7.940  -7.137  16.228  1.00 65.44  ? 238 ASN A CG   1 
ATOM   3567 O OD1  . ASN A 1 238 ? -8.723  -6.816  17.121  1.00 68.84  ? 238 ASN A OD1  1 
ATOM   3568 N ND2  . ASN A 1 238 ? -6.713  -6.638  16.137  1.00 63.52  ? 238 ASN A ND2  1 
ATOM   3569 H H    . ASN A 1 238 ? -10.781 -9.915  14.798  1.00 69.34  ? 238 ASN A H    1 
ATOM   3570 H HA   . ASN A 1 238 ? -10.285 -8.151  15.845  1.00 65.55  ? 238 ASN A HA   1 
ATOM   3571 H HB2  . ASN A 1 238 ? -8.034  -9.009  15.438  1.00 74.38  ? 238 ASN A HB2  1 
ATOM   3572 H HB3  . ASN A 1 238 ? -7.929  -7.872  14.332  1.00 74.38  ? 238 ASN A HB3  1 
ATOM   3573 H HD21 . ASN A 1 238 ? -6.436  -6.068  16.718  1.00 76.28  ? 238 ASN A HD21 1 
ATOM   3574 H HD22 . ASN A 1 238 ? -6.196  -6.885  15.496  1.00 76.28  ? 238 ASN A HD22 1 
ATOM   3575 N N    . TYR A 1 239 ? -11.611 -7.018  13.773  1.00 50.05  ? 239 TYR A N    1 
ATOM   3576 C CA   . TYR A 1 239 ? -12.273 -5.926  13.084  1.00 54.30  ? 239 TYR A CA   1 
ATOM   3577 C C    . TYR A 1 239 ? -13.300 -5.305  14.022  1.00 46.94  ? 239 TYR A C    1 
ATOM   3578 O O    . TYR A 1 239 ? -13.914 -5.993  14.843  1.00 42.61  ? 239 TYR A O    1 
ATOM   3579 C CB   . TYR A 1 239 ? -12.957 -6.420  11.803  1.00 51.06  ? 239 TYR A CB   1 
ATOM   3580 C CG   . TYR A 1 239 ? -12.102 -6.341  10.548  1.00 44.27  ? 239 TYR A CG   1 
ATOM   3581 C CD1  . TYR A 1 239 ? -10.862 -6.963  10.484  1.00 46.99  ? 239 TYR A CD1  1 
ATOM   3582 C CD2  . TYR A 1 239 ? -12.547 -5.654  9.423   1.00 41.94  ? 239 TYR A CD2  1 
ATOM   3583 C CE1  . TYR A 1 239 ? -10.084 -6.895  9.338   1.00 58.37  ? 239 TYR A CE1  1 
ATOM   3584 C CE2  . TYR A 1 239 ? -11.774 -5.582  8.271   1.00 41.34  ? 239 TYR A CE2  1 
ATOM   3585 C CZ   . TYR A 1 239 ? -10.543 -6.206  8.236   1.00 47.99  ? 239 TYR A CZ   1 
ATOM   3586 O OH   . TYR A 1 239 ? -9.767  -6.142  7.100   1.00 42.65  ? 239 TYR A OH   1 
ATOM   3587 H H    . TYR A 1 239 ? -12.118 -7.704  13.884  1.00 60.12  ? 239 TYR A H    1 
ATOM   3588 H HA   . TYR A 1 239 ? -11.631 -5.245  12.828  1.00 65.22  ? 239 TYR A HA   1 
ATOM   3589 H HB2  . TYR A 1 239 ? -13.207 -7.348  11.928  1.00 61.34  ? 239 TYR A HB2  1 
ATOM   3590 H HB3  . TYR A 1 239 ? -13.748 -5.880  11.650  1.00 61.34  ? 239 TYR A HB3  1 
ATOM   3591 H HD1  . TYR A 1 239 ? -10.548 -7.434  11.222  1.00 56.44  ? 239 TYR A HD1  1 
ATOM   3592 H HD2  . TYR A 1 239 ? -13.376 -5.235  9.443   1.00 50.38  ? 239 TYR A HD2  1 
ATOM   3593 H HE1  . TYR A 1 239 ? -9.254  -7.314  9.313   1.00 70.11  ? 239 TYR A HE1  1 
ATOM   3594 H HE2  . TYR A 1 239 ? -12.084 -5.117  7.527   1.00 49.66  ? 239 TYR A HE2  1 
ATOM   3595 H HH   . TYR A 1 239 ? -10.144 -5.665  6.521   1.00 51.24  ? 239 TYR A HH   1 
ATOM   3596 N N    . GLU A 1 240 ? -13.476 -3.994  13.903  1.00 44.04  ? 240 GLU A N    1 
ATOM   3597 C CA   . GLU A 1 240 ? -14.450 -3.299  14.731  1.00 46.52  ? 240 GLU A CA   1 
ATOM   3598 C C    . GLU A 1 240 ? -15.869 -3.728  14.362  1.00 53.82  ? 240 GLU A C    1 
ATOM   3599 O O    . GLU A 1 240 ? -16.154 -4.017  13.197  1.00 53.79  ? 240 GLU A O    1 
ATOM   3600 C CB   . GLU A 1 240 ? -14.306 -1.792  14.556  1.00 54.43  ? 240 GLU A CB   1 
ATOM   3601 C CG   . GLU A 1 240 ? -13.160 -1.187  15.339  1.00 68.84  ? 240 GLU A CG   1 
ATOM   3602 C CD   . GLU A 1 240 ? -13.449 0.233   15.776  1.00 87.16  ? 240 GLU A CD   1 
ATOM   3603 O OE1  . GLU A 1 240 ? -13.314 0.518   16.984  1.00 70.53  ? 240 GLU A OE1  1 
ATOM   3604 O OE2  . GLU A 1 240 ? -13.810 1.061   14.911  1.00 77.76  ? 240 GLU A OE2  1 
ATOM   3605 H H    . GLU A 1 240 ? -13.048 -3.488  13.356  1.00 52.91  ? 240 GLU A H    1 
ATOM   3606 H HA   . GLU A 1 240 ? -14.300 -3.518  15.664  1.00 55.88  ? 240 GLU A HA   1 
ATOM   3607 H HB2  . GLU A 1 240 ? -14.156 -1.601  13.617  1.00 65.38  ? 240 GLU A HB2  1 
ATOM   3608 H HB3  . GLU A 1 240 ? -15.125 -1.366  14.855  1.00 65.38  ? 240 GLU A HB3  1 
ATOM   3609 H HG2  . GLU A 1 240 ? -13.001 -1.721  16.133  1.00 82.67  ? 240 GLU A HG2  1 
ATOM   3610 H HG3  . GLU A 1 240 ? -12.366 -1.176  14.782  1.00 82.67  ? 240 GLU A HG3  1 
ATOM   3611 N N    . PRO A 1 241 ? -16.779 -3.783  15.335  1.00 54.45  ? 241 PRO A N    1 
ATOM   3612 C CA   . PRO A 1 241 ? -18.174 -4.106  15.005  1.00 51.81  ? 241 PRO A CA   1 
ATOM   3613 C C    . PRO A 1 241 ? -18.746 -3.107  14.009  1.00 45.83  ? 241 PRO A C    1 
ATOM   3614 O O    . PRO A 1 241 ? -18.414 -1.920  14.030  1.00 55.66  ? 241 PRO A O    1 
ATOM   3615 C CB   . PRO A 1 241 ? -18.889 -4.033  16.360  1.00 54.11  ? 241 PRO A CB   1 
ATOM   3616 C CG   . PRO A 1 241 ? -17.809 -4.264  17.371  1.00 43.00  ? 241 PRO A CG   1 
ATOM   3617 C CD   . PRO A 1 241 ? -16.582 -3.611  16.788  1.00 55.45  ? 241 PRO A CD   1 
ATOM   3618 H HA   . PRO A 1 241 ? -18.246 -5.005  14.649  1.00 62.23  ? 241 PRO A HA   1 
ATOM   3619 H HB2  . PRO A 1 241 ? -19.293 -3.159  16.476  1.00 64.99  ? 241 PRO A HB2  1 
ATOM   3620 H HB3  . PRO A 1 241 ? -19.570 -4.722  16.413  1.00 64.99  ? 241 PRO A HB3  1 
ATOM   3621 H HG2  . PRO A 1 241 ? -18.053 -3.853  18.215  1.00 51.66  ? 241 PRO A HG2  1 
ATOM   3622 H HG3  . PRO A 1 241 ? -17.670 -5.216  17.494  1.00 51.66  ? 241 PRO A HG3  1 
ATOM   3623 H HD2  . PRO A 1 241 ? -16.543 -2.671  17.025  1.00 66.60  ? 241 PRO A HD2  1 
ATOM   3624 H HD3  . PRO A 1 241 ? -15.775 -4.061  17.084  1.00 66.60  ? 241 PRO A HD3  1 
ATOM   3625 N N    . LEU A 1 242 ? -19.607 -3.606  13.125  1.00 55.82  ? 242 LEU A N    1 
ATOM   3626 C CA   . LEU A 1 242 ? -20.310 -2.777  12.156  1.00 52.80  ? 242 LEU A CA   1 
ATOM   3627 C C    . LEU A 1 242 ? -21.712 -2.487  12.675  1.00 52.97  ? 242 LEU A C    1 
ATOM   3628 O O    . LEU A 1 242 ? -22.452 -3.411  13.033  1.00 49.62  ? 242 LEU A O    1 
ATOM   3629 C CB   . LEU A 1 242 ? -20.385 -3.461  10.791  1.00 63.65  ? 242 LEU A CB   1 
ATOM   3630 C CG   . LEU A 1 242 ? -20.873 -2.597  9.627   1.00 49.94  ? 242 LEU A CG   1 
ATOM   3631 C CD1  . LEU A 1 242 ? -19.843 -1.548  9.237   1.00 47.07  ? 242 LEU A CD1  1 
ATOM   3632 C CD2  . LEU A 1 242 ? -21.217 -3.471  8.427   1.00 56.97  ? 242 LEU A CD2  1 
ATOM   3633 H H    . LEU A 1 242 ? -19.803 -4.441  13.068  1.00 67.04  ? 242 LEU A H    1 
ATOM   3634 H HA   . LEU A 1 242 ? -19.837 -1.938  12.042  1.00 63.42  ? 242 LEU A HA   1 
ATOM   3635 H HB2  . LEU A 1 242 ? -19.495 -3.774  10.562  1.00 76.44  ? 242 LEU A HB2  1 
ATOM   3636 H HB3  . LEU A 1 242 ? -20.993 -4.214  10.864  1.00 76.44  ? 242 LEU A HB3  1 
ATOM   3637 H HG   . LEU A 1 242 ? -21.672 -2.127  9.911   1.00 59.98  ? 242 LEU A HG   1 
ATOM   3638 H HD11 . LEU A 1 242 ? -20.182 -1.037  8.485   1.00 56.54  ? 242 LEU A HD11 1 
ATOM   3639 H HD12 . LEU A 1 242 ? -19.689 -0.960  9.993   1.00 56.54  ? 242 LEU A HD12 1 
ATOM   3640 H HD13 . LEU A 1 242 ? -19.017 -1.993  8.990   1.00 56.54  ? 242 LEU A HD13 1 
ATOM   3641 H HD21 . LEU A 1 242 ? -21.561 -2.909  7.715   1.00 68.43  ? 242 LEU A HD21 1 
ATOM   3642 H HD22 . LEU A 1 242 ? -20.414 -3.928  8.129   1.00 68.43  ? 242 LEU A HD22 1 
ATOM   3643 H HD23 . LEU A 1 242 ? -21.888 -4.120  8.690   1.00 68.43  ? 242 LEU A HD23 1 
ATOM   3644 N N    . THR A 1 243 ? -22.068 -1.208  12.713  1.00 48.12  ? 243 THR A N    1 
ATOM   3645 C CA   . THR A 1 243 ? -23.348 -0.752  13.232  1.00 50.58  ? 243 THR A CA   1 
ATOM   3646 C C    . THR A 1 243 ? -24.283 -0.380  12.087  1.00 58.40  ? 243 THR A C    1 
ATOM   3647 O O    . THR A 1 243 ? -23.863 -0.183  10.944  1.00 47.81  ? 243 THR A O    1 
ATOM   3648 C CB   . THR A 1 243 ? -23.157 0.459   14.152  1.00 53.99  ? 243 THR A CB   1 
ATOM   3649 O OG1  . THR A 1 243 ? -22.833 1.611   13.361  1.00 54.86  ? 243 THR A OG1  1 
ATOM   3650 C CG2  . THR A 1 243 ? -22.044 0.207   15.164  1.00 52.50  ? 243 THR A CG2  1 
ATOM   3651 H H    . THR A 1 243 ? -21.568 -0.567  12.434  1.00 57.80  ? 243 THR A H    1 
ATOM   3652 H HA   . THR A 1 243 ? -23.756 -1.467  13.745  1.00 60.76  ? 243 THR A HA   1 
ATOM   3653 H HB   . THR A 1 243 ? -23.977 0.620   14.645  1.00 64.85  ? 243 THR A HB   1 
ATOM   3654 H HG1  . THR A 1 243 ? -22.111 1.484   12.951  1.00 65.89  ? 243 THR A HG1  1 
ATOM   3655 H HG21 . THR A 1 243 ? -22.034 0.914   15.828  1.00 63.06  ? 243 THR A HG21 1 
ATOM   3656 H HG22 . THR A 1 243 ? -22.187 -0.642  15.610  1.00 63.06  ? 243 THR A HG22 1 
ATOM   3657 H HG23 . THR A 1 243 ? -21.185 0.186   14.713  1.00 63.06  ? 243 THR A HG23 1 
ATOM   3658 N N    . GLN A 1 244 ? -25.573 -0.282  12.413  1.00 54.62  ? 244 GLN A N    1 
ATOM   3659 C CA   . GLN A 1 244 ? -26.541 0.178   11.426  1.00 50.84  ? 244 GLN A CA   1 
ATOM   3660 C C    . GLN A 1 244 ? -26.184 1.564   10.909  1.00 52.44  ? 244 GLN A C    1 
ATOM   3661 O O    . GLN A 1 244 ? -26.483 1.895   9.756   1.00 48.69  ? 244 GLN A O    1 
ATOM   3662 C CB   . GLN A 1 244 ? -27.946 0.187   12.025  1.00 54.30  ? 244 GLN A CB   1 
ATOM   3663 C CG   . GLN A 1 244 ? -29.035 0.535   11.025  1.00 47.89  ? 244 GLN A CG   1 
ATOM   3664 C CD   . GLN A 1 244 ? -29.041 -0.396  9.830   1.00 55.00  ? 244 GLN A CD   1 
ATOM   3665 O OE1  . GLN A 1 244 ? -28.949 -1.615  9.981   1.00 60.74  ? 244 GLN A OE1  1 
ATOM   3666 N NE2  . GLN A 1 244 ? -29.144 0.173   8.634   1.00 52.78  ? 244 GLN A NE2  1 
ATOM   3667 H H    . GLN A 1 244 ? -25.905 -0.472  13.184  1.00 65.60  ? 244 GLN A H    1 
ATOM   3668 H HA   . GLN A 1 244 ? -26.540 -0.438  10.677  1.00 61.07  ? 244 GLN A HA   1 
ATOM   3669 H HB2  . GLN A 1 244 ? -28.139 -0.696  12.378  1.00 65.22  ? 244 GLN A HB2  1 
ATOM   3670 H HB3  . GLN A 1 244 ? -27.977 0.844   12.738  1.00 65.22  ? 244 GLN A HB3  1 
ATOM   3671 H HG2  . GLN A 1 244 ? -29.899 0.471   11.461  1.00 57.53  ? 244 GLN A HG2  1 
ATOM   3672 H HG3  . GLN A 1 244 ? -28.892 1.439   10.702  1.00 57.53  ? 244 GLN A HG3  1 
ATOM   3673 H HE21 . GLN A 1 244 ? -29.203 1.028   8.568   1.00 63.40  ? 244 GLN A HE21 1 
ATOM   3674 H HE22 . GLN A 1 244 ? -29.151 -0.314  7.925   1.00 63.40  ? 244 GLN A HE22 1 
ATOM   3675 N N    . ASP A 1 245 ? -25.549 2.389   11.745  1.00 44.66  ? 245 ASP A N    1 
ATOM   3676 C CA   . ASP A 1 245 ? -25.159 3.721   11.300  1.00 52.90  ? 245 ASP A CA   1 
ATOM   3677 C C    . ASP A 1 245 ? -24.043 3.661   10.266  1.00 49.00  ? 245 ASP A C    1 
ATOM   3678 O O    . ASP A 1 245 ? -23.976 4.520   9.379   1.00 48.15  ? 245 ASP A O    1 
ATOM   3679 C CB   . ASP A 1 245 ? -24.726 4.572   12.492  1.00 55.63  ? 245 ASP A CB   1 
ATOM   3680 C CG   . ASP A 1 245 ? -24.417 6.002   12.098  1.00 58.00  ? 245 ASP A CG   1 
ATOM   3681 O OD1  . ASP A 1 245 ? -25.309 6.667   11.529  1.00 54.76  ? 245 ASP A OD1  1 
ATOM   3682 O OD2  . ASP A 1 245 ? -23.282 6.458   12.348  1.00 71.61  ? 245 ASP A OD2  1 
ATOM   3683 H H    . ASP A 1 245 ? -25.338 2.204   12.558  1.00 53.65  ? 245 ASP A H    1 
ATOM   3684 H HA   . ASP A 1 245 ? -25.929 4.148   10.892  1.00 63.54  ? 245 ASP A HA   1 
ATOM   3685 H HB2  . ASP A 1 245 ? -25.440 4.588   13.148  1.00 66.81  ? 245 ASP A HB2  1 
ATOM   3686 H HB3  . ASP A 1 245 ? -23.926 4.188   12.883  1.00 66.81  ? 245 ASP A HB3  1 
ATOM   3687 N N    . HIS A 1 246 ? -23.151 2.673   10.369  1.00 53.16  ? 246 HIS A N    1 
ATOM   3688 C CA   . HIS A 1 246 ? -22.144 2.491   9.330   1.00 46.46  ? 246 HIS A CA   1 
ATOM   3689 C C    . HIS A 1 246 ? -22.797 2.102   8.009   1.00 52.36  ? 246 HIS A C    1 
ATOM   3690 O O    . HIS A 1 246 ? -22.367 2.546   6.938   1.00 45.38  ? 246 HIS A O    1 
ATOM   3691 C CB   . HIS A 1 246 ? -21.128 1.432   9.758   1.00 41.69  ? 246 HIS A CB   1 
ATOM   3692 C CG   . HIS A 1 246 ? -20.324 1.810   10.963  1.00 52.59  ? 246 HIS A CG   1 
ATOM   3693 N ND1  . HIS A 1 246 ? -19.851 0.878   11.862  1.00 45.51  ? 246 HIS A ND1  1 
ATOM   3694 C CD2  . HIS A 1 246 ? -19.904 3.015   11.415  1.00 45.55  ? 246 HIS A CD2  1 
ATOM   3695 C CE1  . HIS A 1 246 ? -19.179 1.493   12.818  1.00 49.70  ? 246 HIS A CE1  1 
ATOM   3696 N NE2  . HIS A 1 246 ? -19.194 2.790   12.570  1.00 49.86  ? 246 HIS A NE2  1 
ATOM   3697 H H    . HIS A 1 246 ? -23.110 2.108   11.016  1.00 63.85  ? 246 HIS A H    1 
ATOM   3698 H HA   . HIS A 1 246 ? -21.666 3.325   9.203   1.00 55.80  ? 246 HIS A HA   1 
ATOM   3699 H HB2  . HIS A 1 246 ? -21.603 0.611   9.965   1.00 50.08  ? 246 HIS A HB2  1 
ATOM   3700 H HB3  . HIS A 1 246 ? -20.509 1.281   9.026   1.00 50.08  ? 246 HIS A HB3  1 
ATOM   3701 H HD2  . HIS A 1 246 ? -20.066 3.840   11.019  1.00 54.72  ? 246 HIS A HD2  1 
ATOM   3702 H HE1  . HIS A 1 246 ? -18.764 1.082   13.543  1.00 59.70  ? 246 HIS A HE1  1 
ATOM   3703 H HE2  . HIS A 1 246 ? -18.821 3.396   13.054  1.00 59.89  ? 246 HIS A HE2  1 
ATOM   3704 N N    . VAL A 1 247 ? -23.849 1.285   8.069   1.00 53.20  ? 247 VAL A N    1 
ATOM   3705 C CA   . VAL A 1 247 ? -24.546 0.891   6.850   1.00 46.41  ? 247 VAL A CA   1 
ATOM   3706 C C    . VAL A 1 247 ? -25.212 2.099   6.204   1.00 48.74  ? 247 VAL A C    1 
ATOM   3707 O O    . VAL A 1 247 ? -25.268 2.212   4.973   1.00 50.16  ? 247 VAL A O    1 
ATOM   3708 C CB   . VAL A 1 247 ? -25.564 -0.224  7.152   1.00 40.98  ? 247 VAL A CB   1 
ATOM   3709 C CG1  . VAL A 1 247 ? -26.297 -0.621  5.879   1.00 50.53  ? 247 VAL A CG1  1 
ATOM   3710 C CG2  . VAL A 1 247 ? -24.863 -1.419  7.777   1.00 44.14  ? 247 VAL A CG2  1 
ATOM   3711 H H    . VAL A 1 247 ? -24.173 0.951   8.792   1.00 63.89  ? 247 VAL A H    1 
ATOM   3712 H HA   . VAL A 1 247 ? -23.895 0.538   6.224   1.00 55.75  ? 247 VAL A HA   1 
ATOM   3713 H HB   . VAL A 1 247 ? -26.222 0.100   7.787   1.00 49.23  ? 247 VAL A HB   1 
ATOM   3714 H HG11 . VAL A 1 247 ? -26.781 -1.446  6.038   1.00 60.70  ? 247 VAL A HG11 1 
ATOM   3715 H HG12 . VAL A 1 247 ? -26.917 0.085   5.639   1.00 60.70  ? 247 VAL A HG12 1 
ATOM   3716 H HG13 . VAL A 1 247 ? -25.649 -0.748  5.168   1.00 60.70  ? 247 VAL A HG13 1 
ATOM   3717 H HG21 . VAL A 1 247 ? -25.504 -2.139  7.886   1.00 53.03  ? 247 VAL A HG21 1 
ATOM   3718 H HG22 . VAL A 1 247 ? -24.142 -1.703  7.193   1.00 53.03  ? 247 VAL A HG22 1 
ATOM   3719 H HG23 . VAL A 1 247 ? -24.507 -1.159  8.641   1.00 53.03  ? 247 VAL A HG23 1 
ATOM   3720 N N    . ASP A 1 248 ? -25.737 3.018   7.018   1.00 49.34  ? 248 ASP A N    1 
ATOM   3721 C CA   . ASP A 1 248 ? -26.364 4.213   6.461   1.00 48.10  ? 248 ASP A CA   1 
ATOM   3722 C C    . ASP A 1 248 ? -25.323 5.125   5.821   1.00 40.06  ? 248 ASP A C    1 
ATOM   3723 O O    . ASP A 1 248 ? -25.533 5.642   4.717   1.00 51.44  ? 248 ASP A O    1 
ATOM   3724 C CB   . ASP A 1 248 ? -27.133 4.960   7.549   1.00 57.88  ? 248 ASP A CB   1 
ATOM   3725 C CG   . ASP A 1 248 ? -28.099 4.062   8.299   1.00 62.17  ? 248 ASP A CG   1 
ATOM   3726 O OD1  . ASP A 1 248 ? -28.547 3.046   7.723   1.00 53.55  ? 248 ASP A OD1  1 
ATOM   3727 O OD2  . ASP A 1 248 ? -28.408 4.369   9.468   1.00 52.98  ? 248 ASP A OD2  1 
ATOM   3728 H H    . ASP A 1 248 ? -25.743 2.973   7.877   1.00 59.26  ? 248 ASP A H    1 
ATOM   3729 H HA   . ASP A 1 248 ? -26.997 3.946   5.776   1.00 57.78  ? 248 ASP A HA   1 
ATOM   3730 H HB2  . ASP A 1 248 ? -26.503 5.324   8.189   1.00 69.52  ? 248 ASP A HB2  1 
ATOM   3731 H HB3  . ASP A 1 248 ? -27.644 5.676   7.141   1.00 69.52  ? 248 ASP A HB3  1 
ATOM   3732 N N    . ILE A 1 249 ? -24.192 5.331   6.499   1.00 46.68  ? 249 ILE A N    1 
ATOM   3733 C CA   . ILE A 1 249 ? -23.138 6.175   5.945   1.00 48.22  ? 249 ILE A CA   1 
ATOM   3734 C C    . ILE A 1 249 ? -22.683 5.636   4.596   1.00 43.09  ? 249 ILE A C    1 
ATOM   3735 O O    . ILE A 1 249 ? -22.359 6.402   3.680   1.00 43.71  ? 249 ILE A O    1 
ATOM   3736 C CB   . ILE A 1 249 ? -21.972 6.277   6.945   1.00 50.79  ? 249 ILE A CB   1 
ATOM   3737 C CG1  . ILE A 1 249 ? -22.399 7.098   8.164   1.00 51.36  ? 249 ILE A CG1  1 
ATOM   3738 C CG2  . ILE A 1 249 ? -20.757 6.904   6.292   1.00 54.57  ? 249 ILE A CG2  1 
ATOM   3739 C CD1  . ILE A 1 249 ? -21.598 6.807   9.409   1.00 59.36  ? 249 ILE A CD1  1 
ATOM   3740 H H    . ILE A 1 249 ? -24.014 4.998   7.271   1.00 56.07  ? 249 ILE A H    1 
ATOM   3741 H HA   . ILE A 1 249 ? -23.490 7.067   5.801   1.00 57.92  ? 249 ILE A HA   1 
ATOM   3742 H HB   . ILE A 1 249 ? -21.738 5.381   7.231   1.00 61.01  ? 249 ILE A HB   1 
ATOM   3743 H HG12 . ILE A 1 249 ? -22.293 8.040   7.958   1.00 61.69  ? 249 ILE A HG12 1 
ATOM   3744 H HG13 . ILE A 1 249 ? -23.330 6.904   8.359   1.00 61.69  ? 249 ILE A HG13 1 
ATOM   3745 H HG21 . ILE A 1 249 ? -20.144 7.199   6.984   1.00 65.54  ? 249 ILE A HG21 1 
ATOM   3746 H HG22 . ILE A 1 249 ? -20.326 6.244   5.727   1.00 65.54  ? 249 ILE A HG22 1 
ATOM   3747 H HG23 . ILE A 1 249 ? -21.041 7.662   5.758   1.00 65.54  ? 249 ILE A HG23 1 
ATOM   3748 H HD11 . ILE A 1 249 ? -21.932 7.357   10.135  1.00 71.29  ? 249 ILE A HD11 1 
ATOM   3749 H HD12 . ILE A 1 249 ? -21.694 5.869   9.634   1.00 71.29  ? 249 ILE A HD12 1 
ATOM   3750 H HD13 . ILE A 1 249 ? -20.666 7.013   9.240   1.00 71.29  ? 249 ILE A HD13 1 
ATOM   3751 N N    . LEU A 1 250 ? -22.666 4.312   4.447   1.00 42.69  ? 250 LEU A N    1 
ATOM   3752 C CA   . LEU A 1 250 ? -22.274 3.672   3.198   1.00 46.68  ? 250 LEU A CA   1 
ATOM   3753 C C    . LEU A 1 250 ? -23.385 3.667   2.157   1.00 50.34  ? 250 LEU A C    1 
ATOM   3754 O O    . LEU A 1 250 ? -23.180 3.136   1.061   1.00 52.38  ? 250 LEU A O    1 
ATOM   3755 C CB   . LEU A 1 250 ? -21.832 2.233   3.475   1.00 44.87  ? 250 LEU A CB   1 
ATOM   3756 C CG   . LEU A 1 250 ? -20.493 2.077   4.197   1.00 44.00  ? 250 LEU A CG   1 
ATOM   3757 C CD1  . LEU A 1 250 ? -20.341 0.664   4.741   1.00 43.56  ? 250 LEU A CD1  1 
ATOM   3758 C CD2  . LEU A 1 250 ? -19.338 2.423   3.271   1.00 48.95  ? 250 LEU A CD2  1 
ATOM   3759 H H    . LEU A 1 250 ? -22.881 3.756   5.066   1.00 51.28  ? 250 LEU A H    1 
ATOM   3760 H HA   . LEU A 1 250 ? -21.522 4.157   2.823   1.00 56.07  ? 250 LEU A HA   1 
ATOM   3761 H HB2  . LEU A 1 250 ? -22.507 1.809   4.026   1.00 53.90  ? 250 LEU A HB2  1 
ATOM   3762 H HB3  . LEU A 1 250 ? -21.757 1.770   2.626   1.00 53.90  ? 250 LEU A HB3  1 
ATOM   3763 H HG   . LEU A 1 250 ? -20.467 2.691   4.947   1.00 52.85  ? 250 LEU A HG   1 
ATOM   3764 H HD11 . LEU A 1 250 ? -19.484 0.588   5.188   1.00 52.32  ? 250 LEU A HD11 1 
ATOM   3765 H HD12 . LEU A 1 250 ? -21.059 0.488   5.370   1.00 52.32  ? 250 LEU A HD12 1 
ATOM   3766 H HD13 . LEU A 1 250 ? -20.387 0.035   4.003   1.00 52.32  ? 250 LEU A HD13 1 
ATOM   3767 H HD21 . LEU A 1 250 ? -18.502 2.263   3.735   1.00 58.80  ? 250 LEU A HD21 1 
ATOM   3768 H HD22 . LEU A 1 250 ? -19.389 1.865   2.479   1.00 58.80  ? 250 LEU A HD22 1 
ATOM   3769 H HD23 . LEU A 1 250 ? -19.404 3.358   3.021   1.00 58.80  ? 250 LEU A HD23 1 
ATOM   3770 N N    . GLY A 1 251 ? -24.544 4.239   2.469   1.00 53.04  ? 251 GLY A N    1 
ATOM   3771 C CA   . GLY A 1 251 ? -25.665 4.244   1.561   1.00 54.57  ? 251 GLY A CA   1 
ATOM   3772 C C    . GLY A 1 251 ? -25.308 4.801   0.200   1.00 52.26  ? 251 GLY A C    1 
ATOM   3773 O O    . GLY A 1 251 ? -25.410 4.116   -0.824  1.00 53.14  ? 251 GLY A O    1 
ATOM   3774 H H    . GLY A 1 251 ? -24.702 4.635   3.215   1.00 63.71  ? 251 GLY A H    1 
ATOM   3775 H HA2  . GLY A 1 251 ? -25.986 3.336   1.444   1.00 65.54  ? 251 GLY A HA2  1 
ATOM   3776 H HA3  . GLY A 1 251 ? -26.377 4.785   1.935   1.00 65.54  ? 251 GLY A HA3  1 
ATOM   3777 N N    . PRO A 1 252 ? -24.883 6.068   0.165   1.00 50.97  ? 252 PRO A N    1 
ATOM   3778 C CA   . PRO A 1 252 ? -24.537 6.682   -1.132  1.00 51.18  ? 252 PRO A CA   1 
ATOM   3779 C C    . PRO A 1 252 ? -23.631 5.816   -1.990  1.00 56.08  ? 252 PRO A C    1 
ATOM   3780 O O    . PRO A 1 252 ? -23.907 5.618   -3.180  1.00 52.16  ? 252 PRO A O    1 
ATOM   3781 C CB   . PRO A 1 252 ? -23.860 7.997   -0.717  1.00 53.07  ? 252 PRO A CB   1 
ATOM   3782 C CG   . PRO A 1 252 ? -24.495 8.338   0.594   1.00 52.17  ? 252 PRO A CG   1 
ATOM   3783 C CD   . PRO A 1 252 ? -24.759 7.019   1.287   1.00 54.05  ? 252 PRO A CD   1 
ATOM   3784 H HA   . PRO A 1 252 ? -25.349 6.879   -1.624  1.00 61.48  ? 252 PRO A HA   1 
ATOM   3785 H HB2  . PRO A 1 252 ? -22.904 7.863   -0.619  1.00 63.74  ? 252 PRO A HB2  1 
ATOM   3786 H HB3  . PRO A 1 252 ? -24.033 8.684   -1.379  1.00 63.74  ? 252 PRO A HB3  1 
ATOM   3787 H HG2  . PRO A 1 252 ? -23.888 8.885   1.117   1.00 62.66  ? 252 PRO A HG2  1 
ATOM   3788 H HG3  . PRO A 1 252 ? -25.324 8.817   0.440   1.00 62.66  ? 252 PRO A HG3  1 
ATOM   3789 H HD2  . PRO A 1 252 ? -24.019 6.778   1.865   1.00 64.92  ? 252 PRO A HD2  1 
ATOM   3790 H HD3  . PRO A 1 252 ? -25.582 7.057   1.800   1.00 64.92  ? 252 PRO A HD3  1 
ATOM   3791 N N    . LEU A 1 253 ? -22.549 5.289   -1.416  1.00 44.27  ? 253 LEU A N    1 
ATOM   3792 C CA   . LEU A 1 253 ? -21.685 4.393   -2.175  1.00 45.09  ? 253 LEU A CA   1 
ATOM   3793 C C    . LEU A 1 253 ? -22.437 3.135   -2.589  1.00 45.22  ? 253 LEU A C    1 
ATOM   3794 O O    . LEU A 1 253 ? -22.302 2.668   -3.726  1.00 49.49  ? 253 LEU A O    1 
ATOM   3795 C CB   . LEU A 1 253 ? -20.452 4.030   -1.353  1.00 39.78  ? 253 LEU A CB   1 
ATOM   3796 C CG   . LEU A 1 253 ? -19.475 5.173   -1.097  1.00 44.59  ? 253 LEU A CG   1 
ATOM   3797 C CD1  . LEU A 1 253 ? -18.381 4.715   -0.146  1.00 36.73  ? 253 LEU A CD1  1 
ATOM   3798 C CD2  . LEU A 1 253 ? -18.872 5.683   -2.391  1.00 50.03  ? 253 LEU A CD2  1 
ATOM   3799 H H    . LEU A 1 253 ? -22.299 5.433   -0.605  1.00 53.18  ? 253 LEU A H    1 
ATOM   3800 H HA   . LEU A 1 253 ? -21.387 4.849   -2.977  1.00 54.17  ? 253 LEU A HA   1 
ATOM   3801 H HB2  . LEU A 1 253 ? -20.748 3.702   -0.489  1.00 47.79  ? 253 LEU A HB2  1 
ATOM   3802 H HB3  . LEU A 1 253 ? -19.967 3.334   -1.823  1.00 47.79  ? 253 LEU A HB3  1 
ATOM   3803 H HG   . LEU A 1 253 ? -19.955 5.912   -0.691  1.00 53.56  ? 253 LEU A HG   1 
ATOM   3804 H HD11 . LEU A 1 253 ? -17.766 5.449   0.005   1.00 44.14  ? 253 LEU A HD11 1 
ATOM   3805 H HD12 . LEU A 1 253 ? -18.786 4.445   0.694   1.00 44.14  ? 253 LEU A HD12 1 
ATOM   3806 H HD13 . LEU A 1 253 ? -17.911 3.965   -0.543  1.00 44.14  ? 253 LEU A HD13 1 
ATOM   3807 H HD21 . LEU A 1 253 ? -18.160 6.307   -2.184  1.00 60.09  ? 253 LEU A HD21 1 
ATOM   3808 H HD22 . LEU A 1 253 ? -18.518 4.931   -2.892  1.00 60.09  ? 253 LEU A HD22 1 
ATOM   3809 H HD23 . LEU A 1 253 ? -19.562 6.128   -2.908  1.00 60.09  ? 253 LEU A HD23 1 
ATOM   3810 N N    . SER A 1 254 ? -23.227 2.566   -1.675  1.00 46.75  ? 254 SER A N    1 
ATOM   3811 C CA   . SER A 1 254 ? -24.035 1.406   -2.032  1.00 45.46  ? 254 SER A CA   1 
ATOM   3812 C C    . SER A 1 254 ? -24.978 1.726   -3.183  1.00 50.52  ? 254 SER A C    1 
ATOM   3813 O O    . SER A 1 254 ? -25.248 0.861   -4.025  1.00 50.76  ? 254 SER A O    1 
ATOM   3814 C CB   . SER A 1 254 ? -24.829 0.923   -0.819  1.00 51.07  ? 254 SER A CB   1 
ATOM   3815 O OG   . SER A 1 254 ? -25.751 -0.087  -1.194  1.00 56.98  ? 254 SER A OG   1 
ATOM   3816 H H    . SER A 1 254 ? -23.311 2.828   -0.860  1.00 56.16  ? 254 SER A H    1 
ATOM   3817 H HA   . SER A 1 254 ? -23.446 0.687   -2.308  1.00 54.61  ? 254 SER A HA   1 
ATOM   3818 H HB2  . SER A 1 254 ? -24.214 0.562   -0.162  1.00 61.34  ? 254 SER A HB2  1 
ATOM   3819 H HB3  . SER A 1 254 ? -25.317 1.672   -0.442  1.00 61.34  ? 254 SER A HB3  1 
ATOM   3820 H HG   . SER A 1 254 ? -25.340 -0.752  -1.501  1.00 68.43  ? 254 SER A HG   1 
ATOM   3821 N N    . ALA A 1 255 ? -25.477 2.962   -3.242  1.00 49.18  ? 255 ALA A N    1 
ATOM   3822 C CA   . ALA A 1 255 ? -26.415 3.341   -4.292  1.00 52.87  ? 255 ALA A CA   1 
ATOM   3823 C C    . ALA A 1 255 ? -25.710 3.546   -5.625  1.00 56.48  ? 255 ALA A C    1 
ATOM   3824 O O    . ALA A 1 255 ? -26.200 3.098   -6.668  1.00 51.11  ? 255 ALA A O    1 
ATOM   3825 C CB   . ALA A 1 255 ? -27.161 4.613   -3.891  1.00 56.16  ? 255 ALA A CB   1 
ATOM   3826 H H    . ALA A 1 255 ? -25.289 3.593   -2.690  1.00 59.07  ? 255 ALA A H    1 
ATOM   3827 H HA   . ALA A 1 255 ? -27.064 2.629   -4.400  1.00 63.51  ? 255 ALA A HA   1 
ATOM   3828 H HB1  . ALA A 1 255 ? -27.780 4.852   -4.598  1.00 67.45  ? 255 ALA A HB1  1 
ATOM   3829 H HB2  . ALA A 1 255 ? -27.646 4.449   -3.067  1.00 67.45  ? 255 ALA A HB2  1 
ATOM   3830 H HB3  . ALA A 1 255 ? -26.518 5.328   -3.759  1.00 67.45  ? 255 ALA A HB3  1 
ATOM   3831 N N    . GLN A 1 256 ? -24.563 4.223   -5.611  1.00 56.30  ? 256 GLN A N    1 
ATOM   3832 C CA   . GLN A 1 256 ? -23.846 4.488   -6.852  1.00 50.33  ? 256 GLN A CA   1 
ATOM   3833 C C    . GLN A 1 256 ? -23.404 3.192   -7.520  1.00 55.44  ? 256 GLN A C    1 
ATOM   3834 O O    . GLN A 1 256 ? -23.482 3.063   -8.748  1.00 57.95  ? 256 GLN A O    1 
ATOM   3835 C CB   . GLN A 1 256 ? -22.653 5.396   -6.559  1.00 49.28  ? 256 GLN A CB   1 
ATOM   3836 C CG   . GLN A 1 256 ? -21.670 5.558   -7.692  1.00 58.26  ? 256 GLN A CG   1 
ATOM   3837 C CD   . GLN A 1 256 ? -20.562 6.531   -7.338  1.00 66.63  ? 256 GLN A CD   1 
ATOM   3838 O OE1  . GLN A 1 256 ? -20.518 7.060   -6.227  1.00 72.86  ? 256 GLN A OE1  1 
ATOM   3839 N NE2  . GLN A 1 256 ? -19.660 6.769   -8.282  1.00 76.85  ? 256 GLN A NE2  1 
ATOM   3840 H H    . GLN A 1 256 ? -24.184 4.536   -4.905  1.00 67.61  ? 256 GLN A H    1 
ATOM   3841 H HA   . GLN A 1 256 ? -24.430 4.948   -7.475  1.00 60.46  ? 256 GLN A HA   1 
ATOM   3842 H HB2  . GLN A 1 256 ? -22.988 6.278   -6.337  1.00 59.19  ? 256 GLN A HB2  1 
ATOM   3843 H HB3  . GLN A 1 256 ? -22.166 5.027   -5.805  1.00 59.19  ? 256 GLN A HB3  1 
ATOM   3844 H HG2  . GLN A 1 256 ? -21.267 4.699   -7.893  1.00 69.97  ? 256 GLN A HG2  1 
ATOM   3845 H HG3  . GLN A 1 256 ? -22.135 5.898   -8.473  1.00 69.97  ? 256 GLN A HG3  1 
ATOM   3846 H HE21 . GLN A 1 256 ? -19.723 6.379   -9.046  1.00 92.28  ? 256 GLN A HE21 1 
ATOM   3847 H HE22 . GLN A 1 256 ? -19.012 7.314   -8.129  1.00 92.28  ? 256 GLN A HE22 1 
ATOM   3848 N N    . THR A 1 257 ? -22.958 2.213   -6.733  1.00 48.35  ? 257 THR A N    1 
ATOM   3849 C CA   . THR A 1 257 ? -22.467 0.964   -7.300  1.00 50.36  ? 257 THR A CA   1 
ATOM   3850 C C    . THR A 1 257 ? -23.558 -0.078  -7.509  1.00 46.86  ? 257 THR A C    1 
ATOM   3851 O O    . THR A 1 257 ? -23.333 -1.049  -8.240  1.00 47.95  ? 257 THR A O    1 
ATOM   3852 C CB   . THR A 1 257 ? -21.393 0.343   -6.398  1.00 49.40  ? 257 THR A CB   1 
ATOM   3853 O OG1  . THR A 1 257 ? -21.927 0.151   -5.081  1.00 47.83  ? 257 THR A OG1  1 
ATOM   3854 C CG2  . THR A 1 257 ? -20.170 1.233   -6.333  1.00 45.75  ? 257 THR A CG2  1 
ATOM   3855 H H    . THR A 1 257 ? -22.931 2.250   -5.874  1.00 58.07  ? 257 THR A H    1 
ATOM   3856 H HA   . THR A 1 257 ? -22.069 1.172   -8.159  1.00 60.49  ? 257 THR A HA   1 
ATOM   3857 H HB   . THR A 1 257 ? -21.119 -0.514  -6.760  1.00 59.34  ? 257 THR A HB   1 
ATOM   3858 H HG1  . THR A 1 257 ? -21.403 -0.322  -4.625  1.00 57.45  ? 257 THR A HG1  1 
ATOM   3859 H HG21 . THR A 1 257 ? -19.491 0.824   -5.774  1.00 54.95  ? 257 THR A HG21 1 
ATOM   3860 H HG22 . THR A 1 257 ? -19.807 1.365   -7.223  1.00 54.95  ? 257 THR A HG22 1 
ATOM   3861 H HG23 . THR A 1 257 ? -20.407 2.096   -5.959  1.00 54.95  ? 257 THR A HG23 1 
ATOM   3862 N N    . GLY A 1 258 ? -24.716 0.086   -6.877  1.00 51.11  ? 258 GLY A N    1 
ATOM   3863 C CA   . GLY A 1 258 ? -25.728 -0.948  -6.925  1.00 46.69  ? 258 GLY A CA   1 
ATOM   3864 C C    . GLY A 1 258 ? -25.394 -2.191  -6.136  1.00 54.99  ? 258 GLY A C    1 
ATOM   3865 O O    . GLY A 1 258 ? -26.006 -3.238  -6.360  1.00 55.14  ? 258 GLY A O    1 
ATOM   3866 H H    . GLY A 1 258 ? -24.934 0.780   -6.419  1.00 61.39  ? 258 GLY A H    1 
ATOM   3867 H HA2  . GLY A 1 258 ? -26.559 -0.588  -6.576  1.00 56.09  ? 258 GLY A HA2  1 
ATOM   3868 H HA3  . GLY A 1 258 ? -25.862 -1.210  -7.850  1.00 56.09  ? 258 GLY A HA3  1 
ATOM   3869 N N    . ILE A 1 259 ? -24.435 -2.109  -5.216  1.00 45.89  ? 259 ILE A N    1 
ATOM   3870 C CA   . ILE A 1 259 ? -24.033 -3.234  -4.377  1.00 50.57  ? 259 ILE A CA   1 
ATOM   3871 C C    . ILE A 1 259 ? -24.511 -2.945  -2.962  1.00 56.23  ? 259 ILE A C    1 
ATOM   3872 O O    . ILE A 1 259 ? -24.065 -1.975  -2.334  1.00 51.95  ? 259 ILE A O    1 
ATOM   3873 C CB   . ILE A 1 259 ? -22.512 -3.463  -4.398  1.00 55.62  ? 259 ILE A CB   1 
ATOM   3874 C CG1  . ILE A 1 259 ? -21.941 -3.231  -5.799  1.00 54.30  ? 259 ILE A CG1  1 
ATOM   3875 C CG2  . ILE A 1 259 ? -22.186 -4.868  -3.878  1.00 47.41  ? 259 ILE A CG2  1 
ATOM   3876 C CD1  . ILE A 1 259 ? -22.229 -4.333  -6.787  1.00 63.65  ? 259 ILE A CD1  1 
ATOM   3877 H H    . ILE A 1 259 ? -23.990 -1.391  -5.056  1.00 55.13  ? 259 ILE A H    1 
ATOM   3878 H HA   . ILE A 1 259 ? -24.465 -4.040  -4.702  1.00 60.74  ? 259 ILE A HA   1 
ATOM   3879 H HB   . ILE A 1 259 ? -22.092 -2.816  -3.809  1.00 66.80  ? 259 ILE A HB   1 
ATOM   3880 H HG12 . ILE A 1 259 ? -22.321 -2.413  -6.155  1.00 65.21  ? 259 ILE A HG12 1 
ATOM   3881 H HG13 . ILE A 1 259 ? -20.977 -3.146  -5.728  1.00 65.21  ? 259 ILE A HG13 1 
ATOM   3882 H HG21 . ILE A 1 259 ? -21.228 -5.009  -3.927  1.00 56.95  ? 259 ILE A HG21 1 
ATOM   3883 H HG22 . ILE A 1 259 ? -22.485 -4.941  -2.958  1.00 56.95  ? 259 ILE A HG22 1 
ATOM   3884 H HG23 . ILE A 1 259 ? -22.645 -5.522  -4.427  1.00 56.95  ? 259 ILE A HG23 1 
ATOM   3885 H HD11 . ILE A 1 259 ? -21.873 -4.081  -7.653  1.00 76.43  ? 259 ILE A HD11 1 
ATOM   3886 H HD12 . ILE A 1 259 ? -21.805 -5.150  -6.480  1.00 76.43  ? 259 ILE A HD12 1 
ATOM   3887 H HD13 . ILE A 1 259 ? -23.188 -4.461  -6.847  1.00 76.43  ? 259 ILE A HD13 1 
ATOM   3888 N N    . ALA A 1 260 ? -25.412 -3.783  -2.458  1.00 47.93  ? 260 ALA A N    1 
ATOM   3889 C CA   . ALA A 1 260 ? -25.956 -3.576  -1.124  1.00 47.31  ? 260 ALA A CA   1 
ATOM   3890 C C    . ALA A 1 260 ? -24.872 -3.777  -0.076  1.00 50.32  ? 260 ALA A C    1 
ATOM   3891 O O    . ALA A 1 260 ? -24.008 -4.648  -0.209  1.00 44.97  ? 260 ALA A O    1 
ATOM   3892 C CB   . ALA A 1 260 ? -27.122 -4.529  -0.871  1.00 48.99  ? 260 ALA A CB   1 
ATOM   3893 H H    . ALA A 1 260 ? -25.721 -4.474  -2.866  1.00 57.57  ? 260 ALA A H    1 
ATOM   3894 H HA   . ALA A 1 260 ? -26.292 -2.669  -1.046  1.00 56.83  ? 260 ALA A HA   1 
ATOM   3895 H HB1  . ALA A 1 260 ? -27.463 -4.380  0.025   1.00 58.84  ? 260 ALA A HB1  1 
ATOM   3896 H HB2  . ALA A 1 260 ? -27.819 -4.356  -1.523  1.00 58.84  ? 260 ALA A HB2  1 
ATOM   3897 H HB3  . ALA A 1 260 ? -26.808 -5.442  -0.957  1.00 58.84  ? 260 ALA A HB3  1 
ATOM   3898 N N    . VAL A 1 261 ? -24.923 -2.962  0.977   1.00 45.69  ? 261 VAL A N    1 
ATOM   3899 C CA   . VAL A 1 261 ? -23.862 -2.978  1.982   1.00 44.35  ? 261 VAL A CA   1 
ATOM   3900 C C    . VAL A 1 261 ? -23.639 -4.395  2.499   1.00 42.09  ? 261 VAL A C    1 
ATOM   3901 O O    . VAL A 1 261 ? -22.502 -4.873  2.588   1.00 47.48  ? 261 VAL A O    1 
ATOM   3902 C CB   . VAL A 1 261 ? -24.192 -2.000  3.124   1.00 44.81  ? 261 VAL A CB   1 
ATOM   3903 C CG1  . VAL A 1 261 ? -23.155 -2.105  4.226   1.00 48.55  ? 261 VAL A CG1  1 
ATOM   3904 C CG2  . VAL A 1 261 ? -24.272 -0.577  2.581   1.00 44.97  ? 261 VAL A CG2  1 
ATOM   3905 H H    . VAL A 1 261 ? -25.554 -2.398  1.132   1.00 54.88  ? 261 VAL A H    1 
ATOM   3906 H HA   . VAL A 1 261 ? -23.037 -2.683  1.565   1.00 53.27  ? 261 VAL A HA   1 
ATOM   3907 H HB   . VAL A 1 261 ? -25.053 -2.229  3.507   1.00 53.83  ? 261 VAL A HB   1 
ATOM   3908 H HG11 . VAL A 1 261 ? -23.237 -1.336  4.811   1.00 58.31  ? 261 VAL A HG11 1 
ATOM   3909 H HG12 . VAL A 1 261 ? -23.309 -2.920  4.728   1.00 58.31  ? 261 VAL A HG12 1 
ATOM   3910 H HG13 . VAL A 1 261 ? -22.271 -2.124  3.827   1.00 58.31  ? 261 VAL A HG13 1 
ATOM   3911 H HG21 . VAL A 1 261 ? -24.470 0.029   3.312   1.00 54.02  ? 261 VAL A HG21 1 
ATOM   3912 H HG22 . VAL A 1 261 ? -23.420 -0.344  2.179   1.00 54.02  ? 261 VAL A HG22 1 
ATOM   3913 H HG23 . VAL A 1 261 ? -24.975 -0.532  1.915   1.00 54.02  ? 261 VAL A HG23 1 
ATOM   3914 N N    . LEU A 1 262 ? -24.724 -5.097  2.836   1.00 46.54  ? 262 LEU A N    1 
ATOM   3915 C CA   . LEU A 1 262 ? -24.579 -6.439  3.391   1.00 48.87  ? 262 LEU A CA   1 
ATOM   3916 C C    . LEU A 1 262 ? -24.129 -7.452  2.346   1.00 50.02  ? 262 LEU A C    1 
ATOM   3917 O O    . LEU A 1 262 ? -23.608 -8.512  2.709   1.00 52.16  ? 262 LEU A O    1 
ATOM   3918 C CB   . LEU A 1 262 ? -25.892 -6.889  4.029   1.00 44.56  ? 262 LEU A CB   1 
ATOM   3919 C CG   . LEU A 1 262 ? -26.184 -6.299  5.411   1.00 59.16  ? 262 LEU A CG   1 
ATOM   3920 C CD1  . LEU A 1 262 ? -27.558 -6.736  5.897   1.00 52.80  ? 262 LEU A CD1  1 
ATOM   3921 C CD2  . LEU A 1 262 ? -25.115 -6.691  6.419   1.00 56.49  ? 262 LEU A CD2  1 
ATOM   3922 H H    . LEU A 1 262 ? -25.536 -4.823  2.754   1.00 55.91  ? 262 LEU A H    1 
ATOM   3923 H HA   . LEU A 1 262 ? -23.905 -6.417  4.088   1.00 58.70  ? 262 LEU A HA   1 
ATOM   3924 H HB2  . LEU A 1 262 ? -26.620 -6.630  3.443   1.00 53.53  ? 262 LEU A HB2  1 
ATOM   3925 H HB3  . LEU A 1 262 ? -25.869 -7.854  4.125   1.00 53.53  ? 262 LEU A HB3  1 
ATOM   3926 H HG   . LEU A 1 262 ? -26.177 -5.331  5.338   1.00 71.05  ? 262 LEU A HG   1 
ATOM   3927 H HD11 . LEU A 1 262 ? -27.724 -6.344  6.769   1.00 63.42  ? 262 LEU A HD11 1 
ATOM   3928 H HD12 . LEU A 1 262 ? -28.228 -6.433  5.265   1.00 63.42  ? 262 LEU A HD12 1 
ATOM   3929 H HD13 . LEU A 1 262 ? -27.577 -7.704  5.961   1.00 63.42  ? 262 LEU A HD13 1 
ATOM   3930 H HD21 . LEU A 1 262 ? -25.450 -6.527  7.315   1.00 67.84  ? 262 LEU A HD21 1 
ATOM   3931 H HD22 . LEU A 1 262 ? -24.908 -7.632  6.310   1.00 67.84  ? 262 LEU A HD22 1 
ATOM   3932 H HD23 . LEU A 1 262 ? -24.320 -6.157  6.261   1.00 67.84  ? 262 LEU A HD23 1 
ATOM   3933 N N    . ASP A 1 263 ? -24.330 -7.159  1.060   1.00 42.42  ? 263 ASP A N    1 
ATOM   3934 C CA   . ASP A 1 263 ? -23.716 -7.972  0.014   1.00 55.81  ? 263 ASP A CA   1 
ATOM   3935 C C    . ASP A 1 263 ? -22.216 -7.712  -0.051  1.00 47.89  ? 263 ASP A C    1 
ATOM   3936 O O    . ASP A 1 263 ? -21.423 -8.651  -0.187  1.00 43.05  ? 263 ASP A O    1 
ATOM   3937 C CB   . ASP A 1 263 ? -24.404 -7.685  -1.322  1.00 61.36  ? 263 ASP A CB   1 
ATOM   3938 C CG   . ASP A 1 263 ? -23.745 -8.386  -2.497  1.00 70.74  ? 263 ASP A CG   1 
ATOM   3939 O OD1  . ASP A 1 263 ? -22.823 -9.205  -2.291  1.00 70.82  ? 263 ASP A OD1  1 
ATOM   3940 O OD2  . ASP A 1 263 ? -24.163 -8.117  -3.643  1.00 76.68  ? 263 ASP A OD2  1 
ATOM   3941 H H    . ASP A 1 263 ? -24.810 -6.506  0.772   1.00 50.96  ? 263 ASP A H    1 
ATOM   3942 H HA   . ASP A 1 263 ? -23.840 -8.915  0.205   1.00 67.03  ? 263 ASP A HA   1 
ATOM   3943 H HB2  . ASP A 1 263 ? -25.325 -7.987  -1.272  1.00 73.69  ? 263 ASP A HB2  1 
ATOM   3944 H HB3  . ASP A 1 263 ? -24.378 -6.730  -1.491  1.00 73.69  ? 263 ASP A HB3  1 
ATOM   3945 N N    . MET A 1 264 ? -21.809 -6.447  0.071   1.00 44.28  ? 264 MET A N    1 
ATOM   3946 C CA   . MET A 1 264 ? -20.385 -6.141  0.172   1.00 47.94  ? 264 MET A CA   1 
ATOM   3947 C C    . MET A 1 264 ? -19.768 -6.792  1.406   1.00 51.44  ? 264 MET A C    1 
ATOM   3948 O O    . MET A 1 264 ? -18.604 -7.210  1.371   1.00 43.22  ? 264 MET A O    1 
ATOM   3949 C CB   . MET A 1 264 ? -20.180 -4.626  0.196   1.00 41.80  ? 264 MET A CB   1 
ATOM   3950 C CG   . MET A 1 264 ? -18.763 -4.159  -0.123  1.00 51.41  ? 264 MET A CG   1 
ATOM   3951 S SD   . MET A 1 264 ? -18.109 -4.774  -1.685  1.00 44.22  ? 264 MET A SD   1 
ATOM   3952 C CE   . MET A 1 264 ? -18.163 -3.292  -2.684  1.00 45.28  ? 264 MET A CE   1 
ATOM   3953 H H    . MET A 1 264 ? -22.327 -5.762  0.098   1.00 53.19  ? 264 MET A H    1 
ATOM   3954 H HA   . MET A 1 264 ? -19.932 -6.483  -0.615  1.00 57.59  ? 264 MET A HA   1 
ATOM   3955 H HB2  . MET A 1 264 ? -20.772 -4.225  -0.460  1.00 50.21  ? 264 MET A HB2  1 
ATOM   3956 H HB3  . MET A 1 264 ? -20.400 -4.301  1.083   1.00 50.21  ? 264 MET A HB3  1 
ATOM   3957 H HG2  . MET A 1 264 ? -18.758 -3.190  -0.165  1.00 61.75  ? 264 MET A HG2  1 
ATOM   3958 H HG3  . MET A 1 264 ? -18.171 -4.464  0.582   1.00 61.75  ? 264 MET A HG3  1 
ATOM   3959 H HE1  . MET A 1 264 ? -17.852 -3.503  -3.579  1.00 54.39  ? 264 MET A HE1  1 
ATOM   3960 H HE2  . MET A 1 264 ? -19.076 -2.968  -2.719  1.00 54.39  ? 264 MET A HE2  1 
ATOM   3961 H HE3  . MET A 1 264 ? -17.588 -2.620  -2.285  1.00 54.39  ? 264 MET A HE3  1 
ATOM   3962 N N    . CYS A 1 265 ? -20.529 -6.904  2.497   1.00 45.62  ? 265 CYS A N    1 
ATOM   3963 C CA   . CYS A 1 265 ? -20.007 -7.564  3.689   1.00 39.67  ? 265 CYS A CA   1 
ATOM   3964 C C    . CYS A 1 265 ? -19.697 -9.031  3.409   1.00 41.05  ? 265 CYS A C    1 
ATOM   3965 O O    . CYS A 1 265 ? -18.714 -9.576  3.924   1.00 43.10  ? 265 CYS A O    1 
ATOM   3966 C CB   . CYS A 1 265 ? -21.001 -7.434  4.841   1.00 52.32  ? 265 CYS A CB   1 
ATOM   3967 S SG   . CYS A 1 265 ? -21.099 -5.773  5.547   1.00 45.70  ? 265 CYS A SG   1 
ATOM   3968 H H    . CYS A 1 265 ? -21.335 -6.611  2.570   1.00 54.80  ? 265 CYS A H    1 
ATOM   3969 H HA   . CYS A 1 265 ? -19.184 -7.127  3.956   1.00 47.66  ? 265 CYS A HA   1 
ATOM   3970 H HB2  . CYS A 1 265 ? -21.885 -7.670  4.517   1.00 62.84  ? 265 CYS A HB2  1 
ATOM   3971 H HB3  . CYS A 1 265 ? -20.735 -8.041  5.551   1.00 62.84  ? 265 CYS A HB3  1 
ATOM   3972 H HG   . CYS A 1 265 ? -21.401 -4.998  4.681   1.00 54.90  ? 265 CYS A HG   1 
ATOM   3973 N N    . ALA A 1 266 ? -20.530 -9.687  2.595   1.00 49.24  ? 266 ALA A N    1 
ATOM   3974 C CA   . ALA A 1 266 ? -20.245 -11.061 2.198   1.00 53.04  ? 266 ALA A CA   1 
ATOM   3975 C C    . ALA A 1 266 ? -18.931 -11.163 1.439   1.00 44.95  ? 266 ALA A C    1 
ATOM   3976 O O    . ALA A 1 266 ? -18.230 -12.176 1.550   1.00 49.20  ? 266 ALA A O    1 
ATOM   3977 C CB   . ALA A 1 266 ? -21.390 -11.607 1.342   1.00 59.14  ? 266 ALA A CB   1 
ATOM   3978 H H    . ALA A 1 266 ? -21.255 -9.362  2.266   1.00 59.15  ? 266 ALA A H    1 
ATOM   3979 H HA   . ALA A 1 266 ? -20.177 -11.608 2.996   1.00 63.71  ? 266 ALA A HA   1 
ATOM   3980 H HB1  . ALA A 1 266 ? -21.191 -12.524 1.095   1.00 71.02  ? 266 ALA A HB1  1 
ATOM   3981 H HB2  . ALA A 1 266 ? -22.212 -11.574 1.856   1.00 71.02  ? 266 ALA A HB2  1 
ATOM   3982 H HB3  . ALA A 1 266 ? -21.476 -11.061 0.545   1.00 71.02  ? 266 ALA A HB3  1 
ATOM   3983 N N    . SER A 1 267 ? -18.585 -10.136 0.661   1.00 48.86  ? 267 SER A N    1 
ATOM   3984 C CA   . SER A 1 267 ? -17.289 -10.130 -0.005  1.00 43.69  ? 267 SER A CA   1 
ATOM   3985 C C    . SER A 1 267 ? -16.160 -9.972  1.005   1.00 41.41  ? 267 SER A C    1 
ATOM   3986 O O    . SER A 1 267 ? -15.139 -10.662 0.918   1.00 46.21  ? 267 SER A O    1 
ATOM   3987 C CB   . SER A 1 267 ? -17.233 -9.011  -1.045  1.00 51.92  ? 267 SER A CB   1 
ATOM   3988 O OG   . SER A 1 267 ? -18.077 -9.289  -2.152  1.00 53.91  ? 267 SER A OG   1 
ATOM   3989 H H    . SER A 1 267 ? -19.073 -9.445  0.508   1.00 58.69  ? 267 SER A H    1 
ATOM   3990 H HA   . SER A 1 267 ? -17.171 -10.974 -0.469  1.00 52.49  ? 267 SER A HA   1 
ATOM   3991 H HB2  . SER A 1 267 ? -17.523 -8.183  -0.630  1.00 62.36  ? 267 SER A HB2  1 
ATOM   3992 H HB3  . SER A 1 267 ? -16.321 -8.922  -1.361  1.00 62.36  ? 267 SER A HB3  1 
ATOM   3993 H HG   . SER A 1 267 ? -18.080 -8.637  -2.681  1.00 64.75  ? 267 SER A HG   1 
ATOM   3994 N N    . LEU A 1 268 ? -16.323 -9.068  1.973   1.00 50.11  ? 268 LEU A N    1 
ATOM   3995 C CA   . LEU A 1 268 ? -15.282 -8.873  2.978   1.00 46.09  ? 268 LEU A CA   1 
ATOM   3996 C C    . LEU A 1 268 ? -15.085 -10.139 3.803   1.00 40.93  ? 268 LEU A C    1 
ATOM   3997 O O    . LEU A 1 268 ? -13.954 -10.601 3.994   1.00 46.23  ? 268 LEU A O    1 
ATOM   3998 C CB   . LEU A 1 268 ? -15.635 -7.687  3.873   1.00 53.15  ? 268 LEU A CB   1 
ATOM   3999 C CG   . LEU A 1 268 ? -14.621 -7.315  4.955   1.00 45.94  ? 268 LEU A CG   1 
ATOM   4000 C CD1  . LEU A 1 268 ? -13.213 -7.233  4.396   1.00 49.71  ? 268 LEU A CD1  1 
ATOM   4001 C CD2  . LEU A 1 268 ? -15.021 -5.992  5.601   1.00 38.33  ? 268 LEU A CD2  1 
ATOM   4002 H H    . LEU A 1 268 ? -17.014 -8.566  2.068   1.00 60.19  ? 268 LEU A H    1 
ATOM   4003 H HA   . LEU A 1 268 ? -14.445 -8.670  2.532   1.00 55.37  ? 268 LEU A HA   1 
ATOM   4004 H HB2  . LEU A 1 268 ? -15.745 -6.907  3.307   1.00 63.83  ? 268 LEU A HB2  1 
ATOM   4005 H HB3  . LEU A 1 268 ? -16.469 -7.891  4.324   1.00 63.83  ? 268 LEU A HB3  1 
ATOM   4006 H HG   . LEU A 1 268 ? -14.618 -8.008  5.633   1.00 55.18  ? 268 LEU A HG   1 
ATOM   4007 H HD11 . LEU A 1 268 ? -12.632 -6.832  5.061   1.00 59.71  ? 268 LEU A HD11 1 
ATOM   4008 H HD12 . LEU A 1 268 ? -12.905 -8.129  4.184   1.00 59.71  ? 268 LEU A HD12 1 
ATOM   4009 H HD13 . LEU A 1 268 ? -13.223 -6.689  3.594   1.00 59.71  ? 268 LEU A HD13 1 
ATOM   4010 H HD21 . LEU A 1 268 ? -14.374 -5.768  6.289   1.00 46.06  ? 268 LEU A HD21 1 
ATOM   4011 H HD22 . LEU A 1 268 ? -15.033 -5.300  4.922   1.00 46.06  ? 268 LEU A HD22 1 
ATOM   4012 H HD23 . LEU A 1 268 ? -15.902 -6.086  5.994   1.00 46.06  ? 268 LEU A HD23 1 
ATOM   4013 N N    . LYS A 1 269 ? -16.183 -10.711 4.308   1.00 48.37  ? 269 LYS A N    1 
ATOM   4014 C CA   . LYS A 1 269 ? -16.100 -11.996 4.997   1.00 40.27  ? 269 LYS A CA   1 
ATOM   4015 C C    . LYS A 1 269 ? -15.262 -12.985 4.197   1.00 54.95  ? 269 LYS A C    1 
ATOM   4016 O O    . LYS A 1 269 ? -14.397 -13.677 4.749   1.00 51.08  ? 269 LYS A O    1 
ATOM   4017 C CB   . LYS A 1 269 ? -17.509 -12.548 5.235   1.00 54.33  ? 269 LYS A CB   1 
ATOM   4018 C CG   . LYS A 1 269 ? -17.574 -13.926 5.881   1.00 65.21  ? 269 LYS A CG   1 
ATOM   4019 C CD   . LYS A 1 269 ? -19.018 -14.362 6.203   1.00 71.39  ? 269 LYS A CD   1 
ATOM   4020 C CE   . LYS A 1 269 ? -19.785 -13.337 7.038   1.00 78.27  ? 269 LYS A CE   1 
ATOM   4021 N NZ   . LYS A 1 269 ? -21.262 -13.581 6.992   1.00 77.22  ? 269 LYS A NZ   1 
ATOM   4022 H H    . LYS A 1 269 ? -16.975 -10.380 4.264   1.00 58.10  ? 269 LYS A H    1 
ATOM   4023 H HA   . LYS A 1 269 ? -15.679 -11.871 5.862   1.00 48.39  ? 269 LYS A HA   1 
ATOM   4024 H HB2  . LYS A 1 269 ? -17.984 -11.933 5.816   1.00 65.25  ? 269 LYS A HB2  1 
ATOM   4025 H HB3  . LYS A 1 269 ? -17.961 -12.609 4.378   1.00 65.25  ? 269 LYS A HB3  1 
ATOM   4026 H HG2  . LYS A 1 269 ? -17.191 -14.579 5.275   1.00 78.31  ? 269 LYS A HG2  1 
ATOM   4027 H HG3  . LYS A 1 269 ? -17.073 -13.910 6.712   1.00 78.31  ? 269 LYS A HG3  1 
ATOM   4028 H HD2  . LYS A 1 269 ? -19.500 -14.490 5.371   1.00 85.72  ? 269 LYS A HD2  1 
ATOM   4029 H HD3  . LYS A 1 269 ? -18.991 -15.193 6.702   1.00 85.72  ? 269 LYS A HD3  1 
ATOM   4030 H HE2  . LYS A 1 269 ? -19.496 -13.395 7.962   1.00 93.98  ? 269 LYS A HE2  1 
ATOM   4031 H HE3  . LYS A 1 269 ? -19.613 -12.448 6.691   1.00 93.98  ? 269 LYS A HE3  1 
ATOM   4032 H HZ1  . LYS A 1 269 ? -21.686 -12.972 7.483   1.00 92.72  ? 269 LYS A HZ1  1 
ATOM   4033 H HZ2  . LYS A 1 269 ? -21.553 -13.530 6.153   1.00 92.72  ? 269 LYS A HZ2  1 
ATOM   4034 H HZ3  . LYS A 1 269 ? -21.447 -14.390 7.313   1.00 92.72  ? 269 LYS A HZ3  1 
ATOM   4035 N N    . GLU A 1 270 ? -15.490 -13.038 2.883   1.00 54.53  ? 270 GLU A N    1 
ATOM   4036 C CA   . GLU A 1 270 ? -14.792 -14.000 2.035   1.00 62.80  ? 270 GLU A CA   1 
ATOM   4037 C C    . GLU A 1 270 ? -13.308 -13.661 1.915   1.00 58.52  ? 270 GLU A C    1 
ATOM   4038 O O    . GLU A 1 270 ? -12.458 -14.559 1.927   1.00 49.32  ? 270 GLU A O    1 
ATOM   4039 C CB   . GLU A 1 270 ? -15.450 -14.041 0.655   1.00 65.17  ? 270 GLU A CB   1 
ATOM   4040 C CG   . GLU A 1 270 ? -16.566 -15.079 0.499   1.00 73.30  ? 270 GLU A CG   1 
ATOM   4041 C CD   . GLU A 1 270 ? -16.043 -16.499 0.393   1.00 99.96  ? 270 GLU A CD   1 
ATOM   4042 O OE1  . GLU A 1 270 ? -15.585 -16.890 -0.703  1.00 107.61 ? 270 GLU A OE1  1 
ATOM   4043 O OE2  . GLU A 1 270 ? -16.097 -17.232 1.403   1.00 94.67  ? 270 GLU A OE2  1 
ATOM   4044 H H    . GLU A 1 270 ? -16.041 -12.531 2.460   1.00 65.50  ? 270 GLU A H    1 
ATOM   4045 H HA   . GLU A 1 270 ? -14.862 -14.882 2.433   1.00 75.42  ? 270 GLU A HA   1 
ATOM   4046 H HB2  . GLU A 1 270 ? -15.836 -13.169 0.474   1.00 78.27  ? 270 GLU A HB2  1 
ATOM   4047 H HB3  . GLU A 1 270 ? -14.768 -14.245 -0.004  1.00 78.27  ? 270 GLU A HB3  1 
ATOM   4048 H HG2  . GLU A 1 270 ? -17.150 -15.033 1.272   1.00 88.01  ? 270 GLU A HG2  1 
ATOM   4049 H HG3  . GLU A 1 270 ? -17.068 -14.884 -0.308  1.00 88.01  ? 270 GLU A HG3  1 
ATOM   4050 N N    . LEU A 1 271 ? -12.977 -12.371 1.798   1.00 53.31  ? 271 LEU A N    1 
ATOM   4051 C CA   . LEU A 1 271 ? -11.574 -11.973 1.730   1.00 51.58  ? 271 LEU A CA   1 
ATOM   4052 C C    . LEU A 1 271 ? -10.856 -12.227 3.050   1.00 44.25  ? 271 LEU A C    1 
ATOM   4053 O O    . LEU A 1 271 ? -9.648  -12.495 3.058   1.00 50.60  ? 271 LEU A O    1 
ATOM   4054 C CB   . LEU A 1 271 ? -11.461 -10.497 1.352   1.00 53.24  ? 271 LEU A CB   1 
ATOM   4055 C CG   . LEU A 1 271 ? -11.986 -10.120 -0.030  1.00 50.90  ? 271 LEU A CG   1 
ATOM   4056 C CD1  . LEU A 1 271 ? -12.177 -8.615  -0.145  1.00 53.49  ? 271 LEU A CD1  1 
ATOM   4057 C CD2  . LEU A 1 271 ? -11.053 -10.608 -1.124  1.00 52.72  ? 271 LEU A CD2  1 
ATOM   4058 H H    . LEU A 1 271 ? -13.537 -11.720 1.757   1.00 64.02  ? 271 LEU A H    1 
ATOM   4059 H HA   . LEU A 1 271 ? -11.138 -12.497 1.040   1.00 61.95  ? 271 LEU A HA   1 
ATOM   4060 H HB2  . LEU A 1 271 ? -11.962 -9.979  2.001   1.00 63.95  ? 271 LEU A HB2  1 
ATOM   4061 H HB3  . LEU A 1 271 ? -10.524 -10.248 1.381   1.00 63.95  ? 271 LEU A HB3  1 
ATOM   4062 H HG   . LEU A 1 271 ? -12.847 -10.551 -0.152  1.00 61.14  ? 271 LEU A HG   1 
ATOM   4063 H HD11 . LEU A 1 271 ? -12.517 -8.407  -1.029  1.00 64.25  ? 271 LEU A HD11 1 
ATOM   4064 H HD12 . LEU A 1 271 ? -12.809 -8.325  0.531   1.00 64.25  ? 271 LEU A HD12 1 
ATOM   4065 H HD13 . LEU A 1 271 ? -11.322 -8.178  -0.008  1.00 64.25  ? 271 LEU A HD13 1 
ATOM   4066 H HD21 . LEU A 1 271 ? -11.391 -10.312 -1.983  1.00 63.32  ? 271 LEU A HD21 1 
ATOM   4067 H HD22 . LEU A 1 271 ? -10.168 -10.240 -0.972  1.00 63.32  ? 271 LEU A HD22 1 
ATOM   4068 H HD23 . LEU A 1 271 ? -11.016 -11.577 -1.099  1.00 63.32  ? 271 LEU A HD23 1 
ATOM   4069 N N    . LEU A 1 272 ? -11.572 -12.137 4.170   1.00 50.89  ? 272 LEU A N    1 
ATOM   4070 C CA   . LEU A 1 272 ? -10.941 -12.391 5.459   1.00 57.61  ? 272 LEU A CA   1 
ATOM   4071 C C    . LEU A 1 272 ? -10.648 -13.873 5.644   1.00 60.98  ? 272 LEU A C    1 
ATOM   4072 O O    . LEU A 1 272 ? -9.602  -14.242 6.192   1.00 55.53  ? 272 LEU A O    1 
ATOM   4073 C CB   . LEU A 1 272 ? -11.835 -11.871 6.581   1.00 50.13  ? 272 LEU A CB   1 
ATOM   4074 C CG   . LEU A 1 272 ? -11.841 -10.350 6.730   1.00 44.66  ? 272 LEU A CG   1 
ATOM   4075 C CD1  . LEU A 1 272 ? -12.983 -9.930  7.639   1.00 43.99  ? 272 LEU A CD1  1 
ATOM   4076 C CD2  . LEU A 1 272 ? -10.513 -9.841  7.260   1.00 44.35  ? 272 LEU A CD2  1 
ATOM   4077 H H    . LEU A 1 272 ? -12.407 -11.936 4.208   1.00 61.12  ? 272 LEU A H    1 
ATOM   4078 H HA   . LEU A 1 272 ? -10.098 -11.913 5.500   1.00 69.19  ? 272 LEU A HA   1 
ATOM   4079 H HB2  . LEU A 1 272 ? -12.746 -12.154 6.406   1.00 60.21  ? 272 LEU A HB2  1 
ATOM   4080 H HB3  . LEU A 1 272 ? -11.526 -12.248 7.420   1.00 60.21  ? 272 LEU A HB3  1 
ATOM   4081 H HG   . LEU A 1 272 ? -11.972 -9.946  5.858   1.00 53.65  ? 272 LEU A HG   1 
ATOM   4082 H HD11 . LEU A 1 272 ? -12.969 -8.965  7.738   1.00 52.84  ? 272 LEU A HD11 1 
ATOM   4083 H HD12 . LEU A 1 272 ? -13.823 -10.209 7.241   1.00 52.84  ? 272 LEU A HD12 1 
ATOM   4084 H HD13 . LEU A 1 272 ? -12.870 -10.353 8.504   1.00 52.84  ? 272 LEU A HD13 1 
ATOM   4085 H HD21 . LEU A 1 272 ? -10.586 -8.889  7.435   1.00 53.28  ? 272 LEU A HD21 1 
ATOM   4086 H HD22 . LEU A 1 272 ? -10.299 -10.312 8.081   1.00 53.28  ? 272 LEU A HD22 1 
ATOM   4087 H HD23 . LEU A 1 272 ? -9.825  -10.003 6.597   1.00 53.28  ? 272 LEU A HD23 1 
ATOM   4088 N N    . GLN A 1 273 ? -11.549 -14.737 5.170   1.00 58.10  ? 273 GLN A N    1 
ATOM   4089 C CA   . GLN A 1 273 ? -11.421 -16.167 5.420   1.00 60.30  ? 273 GLN A CA   1 
ATOM   4090 C C    . GLN A 1 273 ? -10.481 -16.853 4.438   1.00 60.78  ? 273 GLN A C    1 
ATOM   4091 O O    . GLN A 1 273 ? -9.797  -17.812 4.814   1.00 69.11  ? 273 GLN A O    1 
ATOM   4092 C CB   . GLN A 1 273 ? -12.799 -16.828 5.361   1.00 59.16  ? 273 GLN A CB   1 
ATOM   4093 C CG   . GLN A 1 273 ? -13.700 -16.480 6.531   1.00 59.40  ? 273 GLN A CG   1 
ATOM   4094 C CD   . GLN A 1 273 ? -15.159 -16.794 6.267   1.00 68.60  ? 273 GLN A CD   1 
ATOM   4095 O OE1  . GLN A 1 273 ? -15.530 -17.219 5.171   1.00 74.78  ? 273 GLN A OE1  1 
ATOM   4096 N NE2  . GLN A 1 273 ? -15.998 -16.583 7.274   1.00 75.38  ? 273 GLN A NE2  1 
ATOM   4097 H H    . GLN A 1 273 ? -12.238 -14.519 4.704   1.00 69.77  ? 273 GLN A H    1 
ATOM   4098 H HA   . GLN A 1 273 ? -11.056 -16.289 6.311   1.00 72.42  ? 273 GLN A HA   1 
ATOM   4099 H HB2  . GLN A 1 273 ? -13.246 -16.542 4.549   1.00 71.05  ? 273 GLN A HB2  1 
ATOM   4100 H HB3  . GLN A 1 273 ? -12.682 -17.791 5.354   1.00 71.05  ? 273 GLN A HB3  1 
ATOM   4101 H HG2  . GLN A 1 273 ? -13.420 -16.991 7.307   1.00 71.33  ? 273 GLN A HG2  1 
ATOM   4102 H HG3  . GLN A 1 273 ? -13.626 -15.531 6.715   1.00 71.33  ? 273 GLN A HG3  1 
ATOM   4103 H HE21 . GLN A 1 273 ? -15.703 -16.285 8.025   1.00 90.51  ? 273 GLN A HE21 1 
ATOM   4104 H HE22 . GLN A 1 273 ? -16.837 -16.745 7.176   1.00 90.51  ? 273 GLN A HE22 1 
ATOM   4105 N N    . ASN A 1 274 ? -10.428 -16.386 3.188   1.00 57.17  ? 274 ASN A N    1 
ATOM   4106 C CA   . ASN A 1 274 ? -9.650  -17.043 2.148   1.00 66.15  ? 274 ASN A CA   1 
ATOM   4107 C C    . ASN A 1 274 ? -8.464  -16.224 1.657   1.00 68.73  ? 274 ASN A C    1 
ATOM   4108 O O    . ASN A 1 274 ? -7.604  -16.774 0.961   1.00 67.95  ? 274 ASN A O    1 
ATOM   4109 C CB   . ASN A 1 274 ? -10.553 -17.378 0.948   1.00 65.75  ? 274 ASN A CB   1 
ATOM   4110 C CG   . ASN A 1 274 ? -11.698 -18.307 1.317   1.00 73.44  ? 274 ASN A CG   1 
ATOM   4111 O OD1  . ASN A 1 274 ? -12.760 -17.860 1.751   1.00 76.14  ? 274 ASN A OD1  1 
ATOM   4112 N ND2  . ASN A 1 274 ? -11.486 -19.606 1.139   1.00 73.36  ? 274 ASN A ND2  1 
ATOM   4113 H H    . ASN A 1 274 ? -10.842 -15.682 2.920   1.00 68.66  ? 274 ASN A H    1 
ATOM   4114 H HA   . ASN A 1 274 ? -9.301  -17.873 2.509   1.00 79.44  ? 274 ASN A HA   1 
ATOM   4115 H HB2  . ASN A 1 274 ? -10.933 -16.557 0.599   1.00 78.95  ? 274 ASN A HB2  1 
ATOM   4116 H HB3  . ASN A 1 274 ? -10.021 -17.815 0.265   1.00 78.95  ? 274 ASN A HB3  1 
ATOM   4117 H HD21 . ASN A 1 274 ? -10.732 -19.881 0.831   1.00 88.09  ? 274 ASN A HD21 1 
ATOM   4118 H HD22 . ASN A 1 274 ? -12.104 -20.173 1.333   1.00 88.09  ? 274 ASN A HD22 1 
ATOM   4119 N N    . GLY A 1 275 ? -8.388  -14.943 1.998   1.00 64.35  ? 275 GLY A N    1 
ATOM   4120 C CA   . GLY A 1 275 ? -7.335  -14.094 1.481   1.00 55.98  ? 275 GLY A CA   1 
ATOM   4121 C C    . GLY A 1 275 ? -7.648  -13.611 0.077   1.00 59.46  ? 275 GLY A C    1 
ATOM   4122 O O    . GLY A 1 275 ? -8.757  -13.774 -0.441  1.00 58.18  ? 275 GLY A O    1 
ATOM   4123 H H    . GLY A 1 275 ? -8.935  -14.545 2.529   1.00 77.28  ? 275 GLY A H    1 
ATOM   4124 H HA2  . GLY A 1 275 ? -7.229  -13.322 2.058   1.00 67.24  ? 275 GLY A HA2  1 
ATOM   4125 H HA3  . GLY A 1 275 ? -6.501  -14.589 1.459   1.00 67.24  ? 275 GLY A HA3  1 
ATOM   4126 N N    . MET A 1 276 ? -6.639  -13.006 -0.550  1.00 59.46  ? 276 MET A N    1 
ATOM   4127 C CA   . MET A 1 276 ? -6.783  -12.481 -1.902  1.00 64.21  ? 276 MET A CA   1 
ATOM   4128 C C    . MET A 1 276 ? -6.346  -13.467 -2.978  1.00 75.30  ? 276 MET A C    1 
ATOM   4129 O O    . MET A 1 276 ? -6.632  -13.237 -4.158  1.00 74.63  ? 276 MET A O    1 
ATOM   4130 C CB   . MET A 1 276 ? -5.974  -11.189 -2.056  1.00 62.56  ? 276 MET A CB   1 
ATOM   4131 C CG   . MET A 1 276 ? -6.361  -10.095 -1.081  1.00 62.72  ? 276 MET A CG   1 
ATOM   4132 S SD   . MET A 1 276 ? -6.016  -8.457  -1.749  1.00 72.73  ? 276 MET A SD   1 
ATOM   4133 C CE   . MET A 1 276 ? -6.735  -7.419  -0.480  1.00 76.72  ? 276 MET A CE   1 
ATOM   4134 H H    . MET A 1 276 ? -5.859  -12.887 -0.209  1.00 71.41  ? 276 MET A H    1 
ATOM   4135 H HA   . MET A 1 276 ? -7.718  -12.267 -2.041  1.00 77.11  ? 276 MET A HA   1 
ATOM   4136 H HB2  . MET A 1 276 ? -5.036  -11.392 -1.914  1.00 75.13  ? 276 MET A HB2  1 
ATOM   4137 H HB3  . MET A 1 276 ? -6.107  -10.845 -2.953  1.00 75.13  ? 276 MET A HB3  1 
ATOM   4138 H HG2  . MET A 1 276 ? -7.310  -10.154 -0.894  1.00 75.32  ? 276 MET A HG2  1 
ATOM   4139 H HG3  . MET A 1 276 ? -5.853  -10.202 -0.261  1.00 75.32  ? 276 MET A HG3  1 
ATOM   4140 H HE1  . MET A 1 276 ? -6.623  -6.489  -0.731  1.00 92.12  ? 276 MET A HE1  1 
ATOM   4141 H HE2  . MET A 1 276 ? -7.679  -7.628  -0.398  1.00 92.12  ? 276 MET A HE2  1 
ATOM   4142 H HE3  . MET A 1 276 ? -6.284  -7.591  0.362   1.00 92.12  ? 276 MET A HE3  1 
ATOM   4143 N N    . ASN A 1 277 ? -5.666  -14.550 -2.606  1.00 71.86  ? 277 ASN A N    1 
ATOM   4144 C CA   . ASN A 1 277 ? -5.181  -15.535 -3.571  1.00 72.54  ? 277 ASN A CA   1 
ATOM   4145 C C    . ASN A 1 277 ? -4.312  -14.869 -4.639  1.00 75.26  ? 277 ASN A C    1 
ATOM   4146 O O    . ASN A 1 277 ? -4.481  -15.089 -5.839  1.00 65.35  ? 277 ASN A O    1 
ATOM   4147 C CB   . ASN A 1 277 ? -6.347  -16.296 -4.208  1.00 64.61  ? 277 ASN A CB   1 
ATOM   4148 H H    . ASN A 1 277 ? -5.470  -14.739 -1.790  1.00 86.29  ? 277 ASN A H    1 
ATOM   4149 H HA   . ASN A 1 277 ? -4.626  -16.178 -3.102  1.00 87.11  ? 277 ASN A HA   1 
ATOM   4150 N N    . GLY A 1 278 ? -3.380  -14.033 -4.186  1.00 73.27  ? 278 GLY A N    1 
ATOM   4151 C CA   . GLY A 1 278 ? -2.382  -13.443 -5.053  1.00 78.65  ? 278 GLY A CA   1 
ATOM   4152 C C    . GLY A 1 278 ? -2.839  -12.271 -5.891  1.00 79.14  ? 278 GLY A C    1 
ATOM   4153 O O    . GLY A 1 278 ? -2.036  -11.744 -6.673  1.00 78.53  ? 278 GLY A O    1 
ATOM   4154 H H    . GLY A 1 278 ? -3.309  -13.791 -3.364  1.00 87.98  ? 278 GLY A H    1 
ATOM   4155 H HA2  . GLY A 1 278 ? -1.643  -13.138 -4.504  1.00 94.44  ? 278 GLY A HA2  1 
ATOM   4156 H HA3  . GLY A 1 278 ? -2.062  -14.128 -5.660  1.00 94.44  ? 278 GLY A HA3  1 
ATOM   4157 N N    . ARG A 1 279 ? -4.090  -11.843 -5.762  1.00 64.67  ? 279 ARG A N    1 
ATOM   4158 C CA   . ARG A 1 279 ? -4.603  -10.714 -6.522  1.00 58.19  ? 279 ARG A CA   1 
ATOM   4159 C C    . ARG A 1 279 ? -4.483  -9.436  -5.692  1.00 52.22  ? 279 ARG A C    1 
ATOM   4160 O O    . ARG A 1 279 ? -4.058  -9.453  -4.535  1.00 53.14  ? 279 ARG A O    1 
ATOM   4161 C CB   . ARG A 1 279 ? -6.049  -10.979 -6.949  1.00 63.08  ? 279 ARG A CB   1 
ATOM   4162 C CG   . ARG A 1 279 ? -6.169  -11.820 -8.215  1.00 66.80  ? 279 ARG A CG   1 
ATOM   4163 C CD   . ARG A 1 279 ? -7.477  -12.608 -8.265  1.00 65.35  ? 279 ARG A CD   1 
ATOM   4164 N NE   . ARG A 1 279 ? -7.694  -13.399 -7.060  1.00 73.13  ? 279 ARG A NE   1 
ATOM   4165 C CZ   . ARG A 1 279 ? -8.870  -13.874 -6.673  1.00 77.61  ? 279 ARG A CZ   1 
ATOM   4166 N NH1  . ARG A 1 279 ? -9.963  -13.686 -7.392  1.00 78.01  ? 279 ARG A NH1  1 
ATOM   4167 N NH2  . ARG A 1 279 ? -8.951  -14.558 -5.535  1.00 78.58  ? 279 ARG A NH2  1 
ATOM   4168 H H    . ARG A 1 279 ? -4.669  -12.197 -5.233  1.00 77.67  ? 279 ARG A H    1 
ATOM   4169 H HA   . ARG A 1 279 ? -4.073  -10.602 -7.327  1.00 69.88  ? 279 ARG A HA   1 
ATOM   4170 H HB2  . ARG A 1 279 ? -6.503  -11.453 -6.234  1.00 75.75  ? 279 ARG A HB2  1 
ATOM   4171 H HB3  . ARG A 1 279 ? -6.486  -10.129 -7.114  1.00 75.75  ? 279 ARG A HB3  1 
ATOM   4172 H HG2  . ARG A 1 279 ? -6.139  -11.236 -8.989  1.00 80.22  ? 279 ARG A HG2  1 
ATOM   4173 H HG3  . ARG A 1 279 ? -5.434  -12.452 -8.249  1.00 80.22  ? 279 ARG A HG3  1 
ATOM   4174 H HD2  . ARG A 1 279 ? -8.218  -11.989 -8.357  1.00 78.48  ? 279 ARG A HD2  1 
ATOM   4175 H HD3  . ARG A 1 279 ? -7.454  -13.213 -9.023  1.00 78.48  ? 279 ARG A HD3  1 
ATOM   4176 H HE   . ARG A 1 279 ? -7.012  -13.570 -6.565  1.00 87.82  ? 279 ARG A HE   1 
ATOM   4177 H HH11 . ARG A 1 279 ? -9.921  -13.246 -8.130  1.00 93.67  ? 279 ARG A HH11 1 
ATOM   4178 H HH12 . ARG A 1 279 ? -10.715 -14.003 -7.123  1.00 93.67  ? 279 ARG A HH12 1 
ATOM   4179 H HH21 . ARG A 1 279 ? -8.246  -14.687 -5.060  1.00 94.35  ? 279 ARG A HH21 1 
ATOM   4180 H HH22 . ARG A 1 279 ? -9.709  -14.870 -5.274  1.00 94.35  ? 279 ARG A HH22 1 
ATOM   4181 N N    . THR A 1 280 ? -4.854  -8.306  -6.288  1.00 52.48  ? 280 THR A N    1 
ATOM   4182 C CA   . THR A 1 280 ? -4.733  -7.018  -5.628  1.00 50.40  ? 280 THR A CA   1 
ATOM   4183 C C    . THR A 1 280 ? -6.018  -6.220  -5.789  1.00 44.04  ? 280 THR A C    1 
ATOM   4184 O O    . THR A 1 280 ? -6.827  -6.467  -6.688  1.00 49.42  ? 280 THR A O    1 
ATOM   4185 C CB   . THR A 1 280 ? -3.552  -6.203  -6.181  1.00 47.99  ? 280 THR A CB   1 
ATOM   4186 O OG1  . THR A 1 280 ? -3.779  -5.908  -7.567  1.00 50.92  ? 280 THR A OG1  1 
ATOM   4187 C CG2  . THR A 1 280 ? -2.250  -6.973  -6.033  1.00 58.02  ? 280 THR A CG2  1 
ATOM   4188 H H    . THR A 1 280 ? -5.182  -8.264  -7.082  1.00 63.03  ? 280 THR A H    1 
ATOM   4189 H HA   . THR A 1 280 ? -4.589  -7.170  -4.681  1.00 60.54  ? 280 THR A HA   1 
ATOM   4190 H HB   . THR A 1 280 ? -3.471  -5.374  -5.684  1.00 57.64  ? 280 THR A HB   1 
ATOM   4191 H HG1  . THR A 1 280 ? -3.114  -5.509  -7.889  1.00 61.17  ? 280 THR A HG1  1 
ATOM   4192 H HG21 . THR A 1 280 ? -1.510  -6.441  -6.363  1.00 69.69  ? 280 THR A HG21 1 
ATOM   4193 H HG22 . THR A 1 280 ? -2.094  -7.184  -5.099  1.00 69.69  ? 280 THR A HG22 1 
ATOM   4194 H HG23 . THR A 1 280 ? -2.294  -7.800  -6.539  1.00 69.69  ? 280 THR A HG23 1 
ATOM   4195 N N    . ILE A 1 281 ? -6.189  -5.252  -4.893  1.00 45.54  ? 281 ILE A N    1 
ATOM   4196 C CA   . ILE A 1 281 ? -7.309  -4.323  -4.925  1.00 38.54  ? 281 ILE A CA   1 
ATOM   4197 C C    . ILE A 1 281 ? -6.735  -2.917  -4.861  1.00 38.63  ? 281 ILE A C    1 
ATOM   4198 O O    . ILE A 1 281 ? -6.117  -2.543  -3.856  1.00 43.26  ? 281 ILE A O    1 
ATOM   4199 C CB   . ILE A 1 281 ? -8.293  -4.557  -3.767  1.00 40.94  ? 281 ILE A CB   1 
ATOM   4200 C CG1  . ILE A 1 281 ? -8.791  -6.002  -3.781  1.00 45.58  ? 281 ILE A CG1  1 
ATOM   4201 C CG2  . ILE A 1 281 ? -9.449  -3.577  -3.857  1.00 42.06  ? 281 ILE A CG2  1 
ATOM   4202 C CD1  . ILE A 1 281 ? -9.835  -6.292  -2.724  1.00 47.90  ? 281 ILE A CD1  1 
ATOM   4203 H H    . ILE A 1 281 ? -5.650  -5.111  -4.238  1.00 54.70  ? 281 ILE A H    1 
ATOM   4204 H HA   . ILE A 1 281 ? -7.795  -4.427  -5.759  1.00 46.30  ? 281 ILE A HA   1 
ATOM   4205 H HB   . ILE A 1 281 ? -7.833  -4.406  -2.927  1.00 49.19  ? 281 ILE A HB   1 
ATOM   4206 H HG12 . ILE A 1 281 ? -9.185  -6.189  -4.648  1.00 54.75  ? 281 ILE A HG12 1 
ATOM   4207 H HG13 . ILE A 1 281 ? -8.038  -6.594  -3.625  1.00 54.75  ? 281 ILE A HG13 1 
ATOM   4208 H HG21 . ILE A 1 281 ? -10.016 -3.685  -3.077  1.00 50.52  ? 281 ILE A HG21 1 
ATOM   4209 H HG22 . ILE A 1 281 ? -9.096  -2.674  -3.888  1.00 50.52  ? 281 ILE A HG22 1 
ATOM   4210 H HG23 . ILE A 1 281 ? -9.957  -3.761  -4.663  1.00 50.52  ? 281 ILE A HG23 1 
ATOM   4211 H HD11 . ILE A 1 281 ? -9.946  -7.252  -2.645  1.00 57.53  ? 281 ILE A HD11 1 
ATOM   4212 H HD12 . ILE A 1 281 ? -9.539  -5.921  -1.878  1.00 57.53  ? 281 ILE A HD12 1 
ATOM   4213 H HD13 . ILE A 1 281 ? -10.674 -5.883  -2.989  1.00 57.53  ? 281 ILE A HD13 1 
ATOM   4214 N N    . LEU A 1 282 ? -6.941  -2.138  -5.922  1.00 42.73  ? 282 LEU A N    1 
ATOM   4215 C CA   . LEU A 1 282 ? -6.432  -0.770  -5.990  1.00 41.19  ? 282 LEU A CA   1 
ATOM   4216 C C    . LEU A 1 282 ? -4.939  -0.735  -5.669  1.00 44.34  ? 282 LEU A C    1 
ATOM   4217 O O    . LEU A 1 282 ? -4.451  0.146   -4.959  1.00 51.40  ? 282 LEU A O    1 
ATOM   4218 C CB   . LEU A 1 282 ? -7.217  0.151   -5.057  1.00 32.97  ? 282 LEU A CB   1 
ATOM   4219 C CG   . LEU A 1 282 ? -8.642  0.486   -5.507  1.00 36.71  ? 282 LEU A CG   1 
ATOM   4220 C CD1  . LEU A 1 282 ? -9.343  1.367   -4.476  1.00 41.26  ? 282 LEU A CD1  1 
ATOM   4221 C CD2  . LEU A 1 282 ? -8.658  1.159   -6.876  1.00 46.37  ? 282 LEU A CD2  1 
ATOM   4222 H H    . LEU A 1 282 ? -7.378  -2.382  -6.622  1.00 51.33  ? 282 LEU A H    1 
ATOM   4223 H HA   . LEU A 1 282 ? -6.546  -0.439  -6.895  1.00 49.48  ? 282 LEU A HA   1 
ATOM   4224 H HB2  . LEU A 1 282 ? -7.281  -0.278  -4.189  1.00 39.63  ? 282 LEU A HB2  1 
ATOM   4225 H HB3  . LEU A 1 282 ? -6.734  0.988   -4.978  1.00 39.63  ? 282 LEU A HB3  1 
ATOM   4226 H HG   . LEU A 1 282 ? -9.134  -0.347  -5.586  1.00 44.11  ? 282 LEU A HG   1 
ATOM   4227 H HD11 . LEU A 1 282 ? -10.248 1.546   -4.776  1.00 49.57  ? 282 LEU A HD11 1 
ATOM   4228 H HD12 . LEU A 1 282 ? -9.361  0.903   -3.625  1.00 49.57  ? 282 LEU A HD12 1 
ATOM   4229 H HD13 . LEU A 1 282 ? -8.853  2.200   -4.388  1.00 49.57  ? 282 LEU A HD13 1 
ATOM   4230 H HD21 . LEU A 1 282 ? -9.536  1.541   -7.030  1.00 55.70  ? 282 LEU A HD21 1 
ATOM   4231 H HD22 . LEU A 1 282 ? -7.986  1.857   -6.893  1.00 55.70  ? 282 LEU A HD22 1 
ATOM   4232 H HD23 . LEU A 1 282 ? -8.463  0.495   -7.556  1.00 55.70  ? 282 LEU A HD23 1 
ATOM   4233 N N    . GLY A 1 283 ? -4.210  -1.718  -6.193  1.00 46.56  ? 283 GLY A N    1 
ATOM   4234 C CA   . GLY A 1 283 ? -2.773  -1.757  -6.015  1.00 45.06  ? 283 GLY A CA   1 
ATOM   4235 C C    . GLY A 1 283 ? -2.301  -2.164  -4.641  1.00 55.60  ? 283 GLY A C    1 
ATOM   4236 O O    . GLY A 1 283 ? -1.146  -1.908  -4.295  1.00 51.55  ? 283 GLY A O    1 
ATOM   4237 H H    . GLY A 1 283 ? -4.527  -2.371  -6.654  1.00 55.93  ? 283 GLY A H    1 
ATOM   4238 H HA2  . GLY A 1 283 ? -2.400  -2.386  -6.652  1.00 54.13  ? 283 GLY A HA2  1 
ATOM   4239 H HA3  . GLY A 1 283 ? -2.416  -0.874  -6.197  1.00 54.13  ? 283 GLY A HA3  1 
ATOM   4240 N N    . SER A 1 284 ? -3.156  -2.792  -3.842  1.00 45.21  ? 284 SER A N    1 
ATOM   4241 C CA   . SER A 1 284 ? -2.776  -3.268  -2.522  1.00 44.23  ? 284 SER A CA   1 
ATOM   4242 C C    . SER A 1 284 ? -3.077  -4.754  -2.400  1.00 44.54  ? 284 SER A C    1 
ATOM   4243 O O    . SER A 1 284 ? -4.091  -5.239  -2.914  1.00 48.03  ? 284 SER A O    1 
ATOM   4244 C CB   . SER A 1 284 ? -3.506  -2.498  -1.418  1.00 39.67  ? 284 SER A CB   1 
ATOM   4245 O OG   . SER A 1 284 ? -3.159  -3.008  -0.141  1.00 54.52  ? 284 SER A OG   1 
ATOM   4246 H H    . SER A 1 284 ? -3.975  -2.956  -4.048  1.00 54.31  ? 284 SER A H    1 
ATOM   4247 H HA   . SER A 1 284 ? -1.822  -3.139  -2.400  1.00 53.13  ? 284 SER A HA   1 
ATOM   4248 H HB2  . SER A 1 284 ? -3.255  -1.563  -1.464  1.00 47.66  ? 284 SER A HB2  1 
ATOM   4249 H HB3  . SER A 1 284 ? -4.463  -2.592  -1.547  1.00 47.66  ? 284 SER A HB3  1 
ATOM   4250 H HG   . SER A 1 284 ? -3.532  -2.555  0.460   1.00 65.48  ? 284 SER A HG   1 
ATOM   4251 N N    . ALA A 1 285 ? -2.177  -5.473  -1.736  1.00 48.59  ? 285 ALA A N    1 
ATOM   4252 C CA   . ALA A 1 285 ? -2.403  -6.863  -1.369  1.00 48.20  ? 285 ALA A CA   1 
ATOM   4253 C C    . ALA A 1 285 ? -2.978  -6.996  0.033   1.00 42.77  ? 285 ALA A C    1 
ATOM   4254 O O    . ALA A 1 285 ? -3.192  -8.120  0.500   1.00 44.23  ? 285 ALA A O    1 
ATOM   4255 C CB   . ALA A 1 285 ? -1.098  -7.656  -1.469  1.00 54.35  ? 285 ALA A CB   1 
ATOM   4256 H H    . ALA A 1 285 ? -1.413  -5.171  -1.483  1.00 58.37  ? 285 ALA A H    1 
ATOM   4257 H HA   . ALA A 1 285 ? -3.031  -7.258  -1.994  1.00 57.89  ? 285 ALA A HA   1 
ATOM   4258 H HB1  . ALA A 1 285 ? -1.230  -8.532  -1.074  1.00 65.28  ? 285 ALA A HB1  1 
ATOM   4259 H HB2  . ALA A 1 285 ? -0.856  -7.748  -2.404  1.00 65.28  ? 285 ALA A HB2  1 
ATOM   4260 H HB3  . ALA A 1 285 ? -0.401  -7.179  -0.992  1.00 65.28  ? 285 ALA A HB3  1 
ATOM   4261 N N    . LEU A 1 286 ? -3.218  -5.877  0.710   1.00 43.80  ? 286 LEU A N    1 
ATOM   4262 C CA   . LEU A 1 286 ? -3.822  -5.854  2.029   1.00 49.07  ? 286 LEU A CA   1 
ATOM   4263 C C    . LEU A 1 286 ? -5.113  -5.052  1.981   1.00 42.83  ? 286 LEU A C    1 
ATOM   4264 O O    . LEU A 1 286 ? -5.324  -4.219  1.095   1.00 41.96  ? 286 LEU A O    1 
ATOM   4265 C CB   . LEU A 1 286 ? -2.878  -5.241  3.064   1.00 39.65  ? 286 LEU A CB   1 
ATOM   4266 C CG   . LEU A 1 286 ? -1.543  -5.961  3.240   1.00 51.63  ? 286 LEU A CG   1 
ATOM   4267 C CD1  . LEU A 1 286 ? -0.579  -5.065  3.997   1.00 48.47  ? 286 LEU A CD1  1 
ATOM   4268 C CD2  . LEU A 1 286 ? -1.750  -7.281  3.954   1.00 55.50  ? 286 LEU A CD2  1 
ATOM   4269 H H    . LEU A 1 286 ? -3.031  -5.092  0.412   1.00 52.62  ? 286 LEU A H    1 
ATOM   4270 H HA   . LEU A 1 286 ? -4.027  -6.760  2.306   1.00 58.95  ? 286 LEU A HA   1 
ATOM   4271 H HB2  . LEU A 1 286 ? -2.683  -4.329  2.796   1.00 47.64  ? 286 LEU A HB2  1 
ATOM   4272 H HB3  . LEU A 1 286 ? -3.326  -5.246  3.925   1.00 47.64  ? 286 LEU A HB3  1 
ATOM   4273 H HG   . LEU A 1 286 ? -1.152  -6.158  2.374   1.00 62.01  ? 286 LEU A HG   1 
ATOM   4274 H HD11 . LEU A 1 286 ? 0.266   -5.529  4.103   1.00 58.23  ? 286 LEU A HD11 1 
ATOM   4275 H HD12 . LEU A 1 286 ? -0.447  -4.247  3.494   1.00 58.23  ? 286 LEU A HD12 1 
ATOM   4276 H HD13 . LEU A 1 286 ? -0.956  -4.862  4.868   1.00 58.23  ? 286 LEU A HD13 1 
ATOM   4277 H HD21 . LEU A 1 286 ? -0.892  -7.720  4.061   1.00 66.66  ? 286 LEU A HD21 1 
ATOM   4278 H HD22 . LEU A 1 286 ? -2.145  -7.111  4.824   1.00 66.66  ? 286 LEU A HD22 1 
ATOM   4279 H HD23 . LEU A 1 286 ? -2.342  -7.837  3.424   1.00 66.66  ? 286 LEU A HD23 1 
ATOM   4280 N N    . LEU A 1 287 ? -5.980  -5.314  2.951   1.00 42.34  ? 287 LEU A N    1 
ATOM   4281 C CA   . LEU A 1 287 ? -7.229  -4.577  3.079   1.00 33.59  ? 287 LEU A CA   1 
ATOM   4282 C C    . LEU A 1 287 ? -6.938  -3.238  3.745   1.00 39.55  ? 287 LEU A C    1 
ATOM   4283 O O    . LEU A 1 287 ? -6.419  -3.193  4.866   1.00 42.67  ? 287 LEU A O    1 
ATOM   4284 C CB   . LEU A 1 287 ? -8.238  -5.403  3.867   1.00 45.01  ? 287 LEU A CB   1 
ATOM   4285 C CG   . LEU A 1 287 ? -8.580  -6.720  3.158   1.00 52.49  ? 287 LEU A CG   1 
ATOM   4286 C CD1  . LEU A 1 287 ? -9.263  -7.707  4.088   1.00 48.81  ? 287 LEU A CD1  1 
ATOM   4287 C CD2  . LEU A 1 287 ? -9.444  -6.446  1.927   1.00 54.28  ? 287 LEU A CD2  1 
ATOM   4288 H H    . LEU A 1 287 ? -5.866  -5.918  3.552   1.00 50.87  ? 287 LEU A H    1 
ATOM   4289 H HA   . LEU A 1 287 ? -7.617  -4.400  2.207   1.00 40.37  ? 287 LEU A HA   1 
ATOM   4290 H HB2  . LEU A 1 287 ? -7.865  -5.613  4.738   1.00 54.07  ? 287 LEU A HB2  1 
ATOM   4291 H HB3  . LEU A 1 287 ? -9.056  -4.892  3.971   1.00 54.07  ? 287 LEU A HB3  1 
ATOM   4292 H HG   . LEU A 1 287 ? -7.751  -7.136  2.872   1.00 63.04  ? 287 LEU A HG   1 
ATOM   4293 H HD11 . LEU A 1 287 ? -9.449  -8.525  3.599   1.00 58.62  ? 287 LEU A HD11 1 
ATOM   4294 H HD12 . LEU A 1 287 ? -8.676  -7.895  4.836   1.00 58.62  ? 287 LEU A HD12 1 
ATOM   4295 H HD13 . LEU A 1 287 ? -10.092 -7.318  4.407   1.00 58.62  ? 287 LEU A HD13 1 
ATOM   4296 H HD21 . LEU A 1 287 ? -9.771  -7.289  1.576   1.00 65.19  ? 287 LEU A HD21 1 
ATOM   4297 H HD22 . LEU A 1 287 ? -10.191 -5.883  2.185   1.00 65.19  ? 287 LEU A HD22 1 
ATOM   4298 H HD23 . LEU A 1 287 ? -8.906  -5.995  1.258   1.00 65.19  ? 287 LEU A HD23 1 
ATOM   4299 N N    . GLU A 1 288 ? -7.249  -2.153  3.044   1.00 39.06  ? 288 GLU A N    1 
ATOM   4300 C CA   . GLU A 1 288 ? -6.892  -0.805  3.469   1.00 35.47  ? 288 GLU A CA   1 
ATOM   4301 C C    . GLU A 1 288 ? -8.022  -0.207  4.293   1.00 38.91  ? 288 GLU A C    1 
ATOM   4302 O O    . GLU A 1 288 ? -9.184  -0.259  3.883   1.00 37.34  ? 288 GLU A O    1 
ATOM   4303 C CB   . GLU A 1 288 ? -6.601  0.057   2.236   1.00 41.97  ? 288 GLU A CB   1 
ATOM   4304 C CG   . GLU A 1 288 ? -6.229  1.489   2.533   1.00 58.82  ? 288 GLU A CG   1 
ATOM   4305 C CD   . GLU A 1 288 ? -4.859  1.607   3.163   1.00 68.67  ? 288 GLU A CD   1 
ATOM   4306 O OE1  . GLU A 1 288 ? -4.013  0.719   2.929   1.00 63.90  ? 288 GLU A OE1  1 
ATOM   4307 O OE2  . GLU A 1 288 ? -4.634  2.593   3.897   1.00 65.51  ? 288 GLU A OE2  1 
ATOM   4308 H H    . GLU A 1 288 ? -7.679  -2.172  2.299   1.00 46.93  ? 288 GLU A H    1 
ATOM   4309 H HA   . GLU A 1 288 ? -6.100  -0.826  4.028   1.00 42.62  ? 288 GLU A HA   1 
ATOM   4310 H HB2  . GLU A 1 288 ? -5.862  -0.341  1.751   1.00 50.42  ? 288 GLU A HB2  1 
ATOM   4311 H HB3  . GLU A 1 288 ? -7.395  0.072   1.679   1.00 50.42  ? 288 GLU A HB3  1 
ATOM   4312 H HG2  . GLU A 1 288 ? -6.225  1.994   1.705   1.00 70.64  ? 288 GLU A HG2  1 
ATOM   4313 H HG3  . GLU A 1 288 ? -6.878  1.865   3.148   1.00 70.64  ? 288 GLU A HG3  1 
ATOM   4314 N N    . ASP A 1 289 ? -7.683  0.373   5.449   1.00 37.82  ? 289 ASP A N    1 
ATOM   4315 C CA   . ASP A 1 289 ? -8.702  0.897   6.354   1.00 34.89  ? 289 ASP A CA   1 
ATOM   4316 C C    . ASP A 1 289 ? -8.493  2.364   6.724   1.00 37.69  ? 289 ASP A C    1 
ATOM   4317 O O    . ASP A 1 289 ? -9.125  2.848   7.668   1.00 40.36  ? 289 ASP A O    1 
ATOM   4318 C CB   . ASP A 1 289 ? -8.795  0.020   7.615   1.00 33.97  ? 289 ASP A CB   1 
ATOM   4319 C CG   . ASP A 1 289 ? -7.724  0.330   8.664   1.00 38.70  ? 289 ASP A CG   1 
ATOM   4320 O OD1  . ASP A 1 289 ? -6.681  0.947   8.348   1.00 45.08  ? 289 ASP A OD1  1 
ATOM   4321 O OD2  . ASP A 1 289 ? -7.924  -0.079  9.828   1.00 43.88  ? 289 ASP A OD2  1 
ATOM   4322 H H    . ASP A 1 289 ? -6.875  0.472   5.726   1.00 45.44  ? 289 ASP A H    1 
ATOM   4323 H HA   . ASP A 1 289 ? -9.555  0.858   5.893   1.00 41.93  ? 289 ASP A HA   1 
ATOM   4324 H HB2  . ASP A 1 289 ? -9.662  0.159   8.028   1.00 40.82  ? 289 ASP A HB2  1 
ATOM   4325 H HB3  . ASP A 1 289 ? -8.696  -0.910  7.357   1.00 40.82  ? 289 ASP A HB3  1 
ATOM   4326 N N    . GLU A 1 290 ? -7.668  3.102   5.979   1.00 31.36  ? 290 GLU A N    1 
ATOM   4327 C CA   . GLU A 1 290 ? -7.434  4.512   6.268   1.00 36.13  ? 290 GLU A CA   1 
ATOM   4328 C C    . GLU A 1 290 ? -8.156  5.439   5.290   1.00 40.98  ? 290 GLU A C    1 
ATOM   4329 O O    . GLU A 1 290 ? -7.749  6.597   5.132   1.00 41.95  ? 290 GLU A O    1 
ATOM   4330 C CB   . GLU A 1 290 ? -5.923  4.791   6.296   1.00 42.32  ? 290 GLU A CB   1 
ATOM   4331 C CG   . GLU A 1 290 ? -5.189  3.964   7.372   1.00 54.12  ? 290 GLU A CG   1 
ATOM   4332 C CD   . GLU A 1 290 ? -4.220  4.765   8.244   1.00 57.58  ? 290 GLU A CD   1 
ATOM   4333 O OE1  . GLU A 1 290 ? -3.764  5.845   7.813   1.00 55.07  ? 290 GLU A OE1  1 
ATOM   4334 O OE2  . GLU A 1 290 ? -3.912  4.305   9.367   1.00 43.81  ? 290 GLU A OE2  1 
ATOM   4335 H H    . GLU A 1 290 ? -7.233  2.805   5.299   1.00 37.68  ? 290 GLU A H    1 
ATOM   4336 H HA   . GLU A 1 290 ? -7.782  4.717   7.150   1.00 43.41  ? 290 GLU A HA   1 
ATOM   4337 H HB2  . GLU A 1 290 ? -5.544  4.566   5.432   1.00 50.84  ? 290 GLU A HB2  1 
ATOM   4338 H HB3  . GLU A 1 290 ? -5.778  5.731   6.488   1.00 50.84  ? 290 GLU A HB3  1 
ATOM   4339 H HG2  . GLU A 1 290 ? -5.850  3.567   7.960   1.00 65.00  ? 290 GLU A HG2  1 
ATOM   4340 H HG3  . GLU A 1 290 ? -4.676  3.269   6.930   1.00 65.00  ? 290 GLU A HG3  1 
ATOM   4341 N N    . PHE A 1 291 ? -9.226  4.961   4.657   1.00 42.00  ? 291 PHE A N    1 
ATOM   4342 C CA   . PHE A 1 291 ? -10.095 5.775   3.818   1.00 40.14  ? 291 PHE A CA   1 
ATOM   4343 C C    . PHE A 1 291 ? -11.489 5.769   4.431   1.00 33.78  ? 291 PHE A C    1 
ATOM   4344 O O    . PHE A 1 291 ? -12.099 4.703   4.566   1.00 37.96  ? 291 PHE A O    1 
ATOM   4345 C CB   . PHE A 1 291 ? -10.162 5.228   2.390   1.00 41.92  ? 291 PHE A CB   1 
ATOM   4346 C CG   . PHE A 1 291 ? -8.925  5.466   1.573   1.00 40.38  ? 291 PHE A CG   1 
ATOM   4347 C CD1  . PHE A 1 291 ? -8.618  6.730   1.097   1.00 42.30  ? 291 PHE A CD1  1 
ATOM   4348 C CD2  . PHE A 1 291 ? -8.084  4.414   1.251   1.00 41.74  ? 291 PHE A CD2  1 
ATOM   4349 C CE1  . PHE A 1 291 ? -7.487  6.942   0.334   1.00 48.04  ? 291 PHE A CE1  1 
ATOM   4350 C CE2  . PHE A 1 291 ? -6.953  4.620   0.489   1.00 43.43  ? 291 PHE A CE2  1 
ATOM   4351 C CZ   . PHE A 1 291 ? -6.657  5.883   0.025   1.00 42.78  ? 291 PHE A CZ   1 
ATOM   4352 H H    . PHE A 1 291 ? -9.475  4.139   4.702   1.00 50.46  ? 291 PHE A H    1 
ATOM   4353 H HA   . PHE A 1 291 ? -9.754  6.683   3.788   1.00 48.22  ? 291 PHE A HA   1 
ATOM   4354 H HB2  . PHE A 1 291 ? -10.304 4.270   2.433   1.00 50.36  ? 291 PHE A HB2  1 
ATOM   4355 H HB3  . PHE A 1 291 ? -10.902 5.653   1.930   1.00 50.36  ? 291 PHE A HB3  1 
ATOM   4356 H HD1  . PHE A 1 291 ? -9.181  7.444   1.294   1.00 50.81  ? 291 PHE A HD1  1 
ATOM   4357 H HD2  . PHE A 1 291 ? -8.284  3.557   1.553   1.00 50.14  ? 291 PHE A HD2  1 
ATOM   4358 H HE1  . PHE A 1 291 ? -7.285  7.797   0.028   1.00 57.71  ? 291 PHE A HE1  1 
ATOM   4359 H HE2  . PHE A 1 291 ? -6.391  3.906   0.288   1.00 52.17  ? 291 PHE A HE2  1 
ATOM   4360 H HZ   . PHE A 1 291 ? -5.899  6.022   -0.496  1.00 51.39  ? 291 PHE A HZ   1 
ATOM   4361 N N    . THR A 1 292 ? -11.998 6.945   4.795   1.00 33.80  ? 292 THR A N    1 
ATOM   4362 C CA   . THR A 1 292 ? -13.372 7.017   5.272   1.00 33.89  ? 292 THR A CA   1 
ATOM   4363 C C    . THR A 1 292 ? -14.342 6.982   4.097   1.00 34.02  ? 292 THR A C    1 
ATOM   4364 O O    . THR A 1 292 ? -13.974 7.305   2.964   1.00 34.19  ? 292 THR A O    1 
ATOM   4365 C CB   . THR A 1 292 ? -13.623 8.300   6.063   1.00 35.34  ? 292 THR A CB   1 
ATOM   4366 O OG1  . THR A 1 292 ? -13.401 9.430   5.211   1.00 34.97  ? 292 THR A OG1  1 
ATOM   4367 C CG2  . THR A 1 292 ? -12.730 8.384   7.284   1.00 35.80  ? 292 THR A CG2  1 
ATOM   4368 H H    . THR A 1 292 ? -11.577 7.694   4.775   1.00 40.62  ? 292 THR A H    1 
ATOM   4369 H HA   . THR A 1 292 ? -13.529 6.262   5.859   1.00 40.73  ? 292 THR A HA   1 
ATOM   4370 H HB   . THR A 1 292 ? -14.540 8.307   6.380   1.00 42.46  ? 292 THR A HB   1 
ATOM   4371 H HG1  . THR A 1 292 ? -13.500 10.141  5.647   1.00 42.02  ? 292 THR A HG1  1 
ATOM   4372 H HG21 . THR A 1 292 ? -12.924 9.194   7.782   1.00 43.02  ? 292 THR A HG21 1 
ATOM   4373 H HG22 . THR A 1 292 ? -12.881 7.618   7.860   1.00 43.02  ? 292 THR A HG22 1 
ATOM   4374 H HG23 . THR A 1 292 ? -11.798 8.396   7.014   1.00 43.02  ? 292 THR A HG23 1 
ATOM   4375 N N    . PRO A 1 293 ? -15.602 6.609   4.343   1.00 31.80  ? 293 PRO A N    1 
ATOM   4376 C CA   . PRO A 1 293 ? -16.626 6.804   3.299   1.00 34.26  ? 293 PRO A CA   1 
ATOM   4377 C C    . PRO A 1 293 ? -16.570 8.189   2.672   1.00 38.81  ? 293 PRO A C    1 
ATOM   4378 O O    . PRO A 1 293 ? -16.695 8.324   1.448   1.00 38.43  ? 293 PRO A O    1 
ATOM   4379 C CB   . PRO A 1 293 ? -17.947 6.571   4.047   1.00 33.95  ? 293 PRO A CB   1 
ATOM   4380 C CG   . PRO A 1 293 ? -17.596 5.787   5.261   1.00 44.15  ? 293 PRO A CG   1 
ATOM   4381 C CD   . PRO A 1 293 ? -16.120 5.903   5.528   1.00 43.42  ? 293 PRO A CD   1 
ATOM   4382 H HA   . PRO A 1 293 ? -16.532 6.125   2.612   1.00 41.17  ? 293 PRO A HA   1 
ATOM   4383 H HB2  . PRO A 1 293 ? -18.339 7.425   4.291   1.00 40.80  ? 293 PRO A HB2  1 
ATOM   4384 H HB3  . PRO A 1 293 ? -18.559 6.075   3.482   1.00 40.80  ? 293 PRO A HB3  1 
ATOM   4385 H HG2  . PRO A 1 293 ? -18.096 6.138   6.015   1.00 53.04  ? 293 PRO A HG2  1 
ATOM   4386 H HG3  . PRO A 1 293 ? -17.831 4.858   5.111   1.00 53.04  ? 293 PRO A HG3  1 
ATOM   4387 H HD2  . PRO A 1 293 ? -15.957 6.419   6.334   1.00 52.17  ? 293 PRO A HD2  1 
ATOM   4388 H HD3  . PRO A 1 293 ? -15.716 5.025   5.609   1.00 52.17  ? 293 PRO A HD3  1 
ATOM   4389 N N    . PHE A 1 294 ? -16.368 9.227   3.490   1.00 42.90  ? 294 PHE A N    1 
ATOM   4390 C CA   . PHE A 1 294 ? -16.266 10.588  2.969   1.00 37.86  ? 294 PHE A CA   1 
ATOM   4391 C C    . PHE A 1 294 ? -15.070 10.741  2.038   1.00 40.23  ? 294 PHE A C    1 
ATOM   4392 O O    . PHE A 1 294 ? -15.171 11.392  0.991   1.00 49.19  ? 294 PHE A O    1 
ATOM   4393 C CB   . PHE A 1 294 ? -16.165 11.574  4.138   1.00 40.19  ? 294 PHE A CB   1 
ATOM   4394 C CG   . PHE A 1 294 ? -16.020 13.017  3.724   1.00 52.12  ? 294 PHE A CG   1 
ATOM   4395 C CD1  . PHE A 1 294 ? -14.853 13.482  3.136   1.00 64.84  ? 294 PHE A CD1  1 
ATOM   4396 C CD2  . PHE A 1 294 ? -17.050 13.912  3.947   1.00 59.33  ? 294 PHE A CD2  1 
ATOM   4397 C CE1  . PHE A 1 294 ? -14.727 14.804  2.760   1.00 59.79  ? 294 PHE A CE1  1 
ATOM   4398 C CE2  . PHE A 1 294 ? -16.927 15.235  3.579   1.00 64.90  ? 294 PHE A CE2  1 
ATOM   4399 C CZ   . PHE A 1 294 ? -15.764 15.683  2.985   1.00 63.40  ? 294 PHE A CZ   1 
ATOM   4400 H H    . PHE A 1 294 ? -16.287 9.169   4.345   1.00 51.54  ? 294 PHE A H    1 
ATOM   4401 H HA   . PHE A 1 294 ? -17.065 10.792  2.459   1.00 45.49  ? 294 PHE A HA   1 
ATOM   4402 H HB2  . PHE A 1 294 ? -16.970 11.502  4.674   1.00 48.28  ? 294 PHE A HB2  1 
ATOM   4403 H HB3  . PHE A 1 294 ? -15.389 11.343  4.672   1.00 48.28  ? 294 PHE A HB3  1 
ATOM   4404 H HD1  . PHE A 1 294 ? -14.146 12.895  2.993   1.00 77.87  ? 294 PHE A HD1  1 
ATOM   4405 H HD2  . PHE A 1 294 ? -17.835 13.618  4.351   1.00 71.25  ? 294 PHE A HD2  1 
ATOM   4406 H HE1  . PHE A 1 294 ? -13.944 15.101  2.355   1.00 71.81  ? 294 PHE A HE1  1 
ATOM   4407 H HE2  . PHE A 1 294 ? -17.629 15.827  3.731   1.00 77.94  ? 294 PHE A HE2  1 
ATOM   4408 H HZ   . PHE A 1 294 ? -15.681 16.575  2.738   1.00 76.14  ? 294 PHE A HZ   1 
ATOM   4409 N N    . ASP A 1 295 ? -13.918 10.183  2.418   1.00 36.52  ? 295 ASP A N    1 
ATOM   4410 C CA   . ASP A 1 295 ? -12.742 10.292  1.564   1.00 47.09  ? 295 ASP A CA   1 
ATOM   4411 C C    . ASP A 1 295 ? -13.011 9.709   0.185   1.00 42.14  ? 295 ASP A C    1 
ATOM   4412 O O    . ASP A 1 295 ? -12.543 10.242  -0.828  1.00 39.60  ? 295 ASP A O    1 
ATOM   4413 C CB   . ASP A 1 295 ? -11.553 9.579   2.202   1.00 39.52  ? 295 ASP A CB   1 
ATOM   4414 C CG   . ASP A 1 295 ? -11.177 10.163  3.535   1.00 42.35  ? 295 ASP A CG   1 
ATOM   4415 O OD1  . ASP A 1 295 ? -11.404 11.375  3.736   1.00 46.27  ? 295 ASP A OD1  1 
ATOM   4416 O OD2  . ASP A 1 295 ? -10.663 9.412   4.387   1.00 35.97  ? 295 ASP A OD2  1 
ATOM   4417 H H    . ASP A 1 295 ? -13.797 9.746   3.149   1.00 43.88  ? 295 ASP A H    1 
ATOM   4418 H HA   . ASP A 1 295 ? -12.519 11.231  1.468   1.00 56.56  ? 295 ASP A HA   1 
ATOM   4419 H HB2  . ASP A 1 295 ? -11.778 8.645   2.336   1.00 47.48  ? 295 ASP A HB2  1 
ATOM   4420 H HB3  . ASP A 1 295 ? -10.785 9.654   1.614   1.00 47.48  ? 295 ASP A HB3  1 
ATOM   4421 N N    . VAL A 1 296 ? -13.748 8.598   0.127   1.00 37.86  ? 296 VAL A N    1 
ATOM   4422 C CA   . VAL A 1 296 ? -14.006 7.952   -1.155  1.00 44.09  ? 296 VAL A CA   1 
ATOM   4423 C C    . VAL A 1 296 ? -14.858 8.855   -2.036  1.00 41.38  ? 296 VAL A C    1 
ATOM   4424 O O    . VAL A 1 296 ? -14.523 9.117   -3.198  1.00 41.58  ? 296 VAL A O    1 
ATOM   4425 C CB   . VAL A 1 296 ? -14.670 6.580   -0.940  1.00 39.47  ? 296 VAL A CB   1 
ATOM   4426 C CG1  . VAL A 1 296 ? -15.037 5.954   -2.277  1.00 40.63  ? 296 VAL A CG1  1 
ATOM   4427 C CG2  . VAL A 1 296 ? -13.746 5.663   -0.159  1.00 31.71  ? 296 VAL A CG2  1 
ATOM   4428 H H    . VAL A 1 296 ? -14.104 8.207   0.806   1.00 45.49  ? 296 VAL A H    1 
ATOM   4429 H HA   . VAL A 1 296 ? -13.159 7.804   -1.605  1.00 52.96  ? 296 VAL A HA   1 
ATOM   4430 H HB   . VAL A 1 296 ? -15.485 6.700   -0.428  1.00 47.42  ? 296 VAL A HB   1 
ATOM   4431 H HG11 . VAL A 1 296 ? -15.223 5.012   -2.145  1.00 48.81  ? 296 VAL A HG11 1 
ATOM   4432 H HG12 . VAL A 1 296 ? -15.823 6.400   -2.630  1.00 48.81  ? 296 VAL A HG12 1 
ATOM   4433 H HG13 . VAL A 1 296 ? -14.294 6.061   -2.891  1.00 48.81  ? 296 VAL A HG13 1 
ATOM   4434 H HG21 . VAL A 1 296 ? -14.168 4.794   -0.066  1.00 38.11  ? 296 VAL A HG21 1 
ATOM   4435 H HG22 . VAL A 1 296 ? -12.909 5.574   -0.641  1.00 38.11  ? 296 VAL A HG22 1 
ATOM   4436 H HG23 . VAL A 1 296 ? -13.586 6.048   0.716   1.00 38.11  ? 296 VAL A HG23 1 
ATOM   4437 N N    . VAL A 1 297 ? -15.963 9.361   -1.486  1.00 41.66  ? 297 VAL A N    1 
ATOM   4438 C CA   . VAL A 1 297 ? -16.835 10.263  -2.233  1.00 49.63  ? 297 VAL A CA   1 
ATOM   4439 C C    . VAL A 1 297 ? -16.072 11.504  -2.682  1.00 51.18  ? 297 VAL A C    1 
ATOM   4440 O O    . VAL A 1 297 ? -16.272 12.003  -3.797  1.00 47.05  ? 297 VAL A O    1 
ATOM   4441 C CB   . VAL A 1 297 ? -18.058 10.633  -1.372  1.00 50.56  ? 297 VAL A CB   1 
ATOM   4442 C CG1  . VAL A 1 297 ? -18.909 11.683  -2.063  1.00 52.87  ? 297 VAL A CG1  1 
ATOM   4443 C CG2  . VAL A 1 297 ? -18.874 9.385   -1.054  1.00 46.78  ? 297 VAL A CG2  1 
ATOM   4444 H H    . VAL A 1 297 ? -16.228 9.199   -0.684  1.00 50.05  ? 297 VAL A H    1 
ATOM   4445 H HA   . VAL A 1 297 ? -17.145 9.807   -3.030  1.00 59.61  ? 297 VAL A HA   1 
ATOM   4446 H HB   . VAL A 1 297 ? -17.751 11.014  -0.535  1.00 60.73  ? 297 VAL A HB   1 
ATOM   4447 H HG11 . VAL A 1 297 ? -19.780 11.715  -1.636  1.00 63.50  ? 297 VAL A HG11 1 
ATOM   4448 H HG12 . VAL A 1 297 ? -18.471 12.545  -1.986  1.00 63.50  ? 297 VAL A HG12 1 
ATOM   4449 H HG13 . VAL A 1 297 ? -19.008 11.445  -2.998  1.00 63.50  ? 297 VAL A HG13 1 
ATOM   4450 H HG21 . VAL A 1 297 ? -19.649 9.640   -0.529  1.00 56.19  ? 297 VAL A HG21 1 
ATOM   4451 H HG22 . VAL A 1 297 ? -19.157 8.973   -1.884  1.00 56.19  ? 297 VAL A HG22 1 
ATOM   4452 H HG23 . VAL A 1 297 ? -18.322 8.767   -0.549  1.00 56.19  ? 297 VAL A HG23 1 
ATOM   4453 N N    . ARG A 1 298 ? -15.195 12.027  -1.815  1.00 49.22  ? 298 ARG A N    1 
ATOM   4454 C CA   . ARG A 1 298 ? -14.414 13.216  -2.157  1.00 56.73  ? 298 ARG A CA   1 
ATOM   4455 C C    . ARG A 1 298 ? -13.617 13.001  -3.434  1.00 49.12  ? 298 ARG A C    1 
ATOM   4456 O O    . ARG A 1 298 ? -13.520 13.898  -4.282  1.00 59.87  ? 298 ARG A O    1 
ATOM   4457 C CB   . ARG A 1 298 ? -13.463 13.569  -1.010  1.00 63.67  ? 298 ARG A CB   1 
ATOM   4458 C CG   . ARG A 1 298 ? -12.968 15.024  -0.989  1.00 73.14  ? 298 ARG A CG   1 
ATOM   4459 C CD   . ARG A 1 298 ? -11.452 15.168  -1.244  1.00 74.25  ? 298 ARG A CD   1 
ATOM   4460 N NE   . ARG A 1 298 ? -10.623 14.776  -0.108  1.00 66.70  ? 298 ARG A NE   1 
ATOM   4461 C CZ   . ARG A 1 298 ? -9.364  15.156  0.074   1.00 62.75  ? 298 ARG A CZ   1 
ATOM   4462 N NH1  . ARG A 1 298 ? -8.758  15.976  -0.770  1.00 58.21  ? 298 ARG A NH1  1 
ATOM   4463 N NH2  . ARG A 1 298 ? -8.697  14.700  1.130   1.00 63.90  ? 298 ARG A NH2  1 
ATOM   4464 H H    . ARG A 1 298 ? -15.037 11.715  -1.029  1.00 59.12  ? 298 ARG A H    1 
ATOM   4465 H HA   . ARG A 1 298 ? -15.026 13.956  -2.292  1.00 68.13  ? 298 ARG A HA   1 
ATOM   4466 H HB2  . ARG A 1 298 ? -13.922 13.408  -0.171  1.00 76.46  ? 298 ARG A HB2  1 
ATOM   4467 H HB3  . ARG A 1 298 ? -12.681 12.999  -1.075  1.00 76.46  ? 298 ARG A HB3  1 
ATOM   4468 H HG2  . ARG A 1 298 ? -13.433 15.522  -1.680  1.00 87.83  ? 298 ARG A HG2  1 
ATOM   4469 H HG3  . ARG A 1 298 ? -13.159 15.407  -0.119  1.00 87.83  ? 298 ARG A HG3  1 
ATOM   4470 H HD2  . ARG A 1 298 ? -11.208 14.606  -1.996  1.00 89.15  ? 298 ARG A HD2  1 
ATOM   4471 H HD3  . ARG A 1 298 ? -11.257 16.096  -1.446  1.00 89.15  ? 298 ARG A HD3  1 
ATOM   4472 H HE   . ARG A 1 298 ? -10.975 14.262  0.485   1.00 80.10  ? 298 ARG A HE   1 
ATOM   4473 H HH11 . ARG A 1 298 ? -9.180  16.275  -1.457  1.00 69.90  ? 298 ARG A HH11 1 
ATOM   4474 H HH12 . ARG A 1 298 ? -7.941  16.208  -0.632  1.00 69.90  ? 298 ARG A HH12 1 
ATOM   4475 H HH21 . ARG A 1 298 ? -9.081  14.166  1.684   1.00 76.74  ? 298 ARG A HH21 1 
ATOM   4476 H HH22 . ARG A 1 298 ? -7.881  14.939  1.259   1.00 76.74  ? 298 ARG A HH22 1 
ATOM   4477 N N    . GLN A 1 299 ? -13.031 11.815  -3.581  1.00 50.76  ? 299 GLN A N    1 
ATOM   4478 C CA   . GLN A 1 299 ? -12.135 11.502  -4.688  1.00 58.35  ? 299 GLN A CA   1 
ATOM   4479 C C    . GLN A 1 299 ? -12.900 10.912  -5.871  1.00 43.07  ? 299 GLN A C    1 
ATOM   4480 O O    . GLN A 1 299 ? -12.883 11.469  -6.973  1.00 63.12  ? 299 GLN A O    1 
ATOM   4481 C CB   . GLN A 1 299 ? -11.050 10.534  -4.197  1.00 46.02  ? 299 GLN A CB   1 
ATOM   4482 C CG   . GLN A 1 299 ? -9.872  10.364  -5.132  1.00 43.38  ? 299 GLN A CG   1 
ATOM   4483 C CD   . GLN A 1 299 ? -8.639  9.771   -4.450  1.00 41.21  ? 299 GLN A CD   1 
ATOM   4484 O OE1  . GLN A 1 299 ? -7.715  9.318   -5.123  1.00 40.09  ? 299 GLN A OE1  1 
ATOM   4485 N NE2  . GLN A 1 299 ? -8.620  9.783   -3.121  1.00 42.70  ? 299 GLN A NE2  1 
ATOM   4486 H H    . GLN A 1 299 ? -13.141 11.157  -3.038  1.00 60.97  ? 299 GLN A H    1 
ATOM   4487 H HA   . GLN A 1 299 ? -11.703 12.315  -4.995  1.00 70.08  ? 299 GLN A HA   1 
ATOM   4488 H HB2  . GLN A 1 299 ? -10.705 10.863  -3.352  1.00 55.28  ? 299 GLN A HB2  1 
ATOM   4489 H HB3  . GLN A 1 299 ? -11.452 9.660   -4.074  1.00 55.28  ? 299 GLN A HB3  1 
ATOM   4490 H HG2  . GLN A 1 299 ? -10.128 9.769   -5.855  1.00 52.11  ? 299 GLN A HG2  1 
ATOM   4491 H HG3  . GLN A 1 299 ? -9.627  11.232  -5.489  1.00 52.11  ? 299 GLN A HG3  1 
ATOM   4492 H HE21 . GLN A 1 299 ? -9.282  10.114  -2.684  1.00 51.30  ? 299 GLN A HE21 1 
ATOM   4493 H HE22 . GLN A 1 299 ? -7.945  9.459   -2.698  1.00 51.30  ? 299 GLN A HE22 1 
ATOM   4494 N N    . CYS A 1 300 ? -13.582 9.790   -5.652  1.00 47.25  ? 300 CYS A N    1 
ATOM   4495 C CA   A CYS A 1 300 ? -14.371 9.163   -6.706  0.50 55.64  ? 300 CYS A CA   1 
ATOM   4496 C CA   B CYS A 1 300 ? -14.371 9.163   -6.706  0.50 55.65  ? 300 CYS A CA   1 
ATOM   4497 C C    . CYS A 1 300 ? -15.600 10.013  -7.000  1.00 62.97  ? 300 CYS A C    1 
ATOM   4498 O O    . CYS A 1 300 ? -16.406 10.282  -6.101  1.00 79.18  ? 300 CYS A O    1 
ATOM   4499 C CB   A CYS A 1 300 ? -14.788 7.756   -6.289  0.50 45.86  ? 300 CYS A CB   1 
ATOM   4500 C CB   B CYS A 1 300 ? -14.789 7.756   -6.288  0.50 45.52  ? 300 CYS A CB   1 
ATOM   4501 S SG   A CYS A 1 300 ? -13.428 6.693   -5.779  0.50 57.86  ? 300 CYS A SG   1 
ATOM   4502 S SG   B CYS A 1 300 ? -13.428 6.692   -5.780  0.50 57.66  ? 300 CYS A SG   1 
ATOM   4503 H H    A CYS A 1 300 ? -13.605 9.372   -4.901  0.50 56.75  ? 300 CYS A H    1 
ATOM   4504 H H    B CYS A 1 300 ? -13.604 9.372   -4.901  0.50 56.75  ? 300 CYS A H    1 
ATOM   4505 H HA   A CYS A 1 300 ? -13.834 9.097   -7.512  0.50 66.83  ? 300 CYS A HA   1 
ATOM   4506 H HA   B CYS A 1 300 ? -13.835 9.096   -7.511  0.50 66.83  ? 300 CYS A HA   1 
ATOM   4507 H HB2  A CYS A 1 300 ? -15.402 7.824   -5.541  0.50 55.09  ? 300 CYS A HB2  1 
ATOM   4508 H HB2  B CYS A 1 300 ? -15.401 7.826   -5.539  0.50 54.68  ? 300 CYS A HB2  1 
ATOM   4509 H HB3  A CYS A 1 300 ? -15.227 7.329   -7.041  0.50 55.09  ? 300 CYS A HB3  1 
ATOM   4510 H HB3  B CYS A 1 300 ? -15.230 7.329   -7.039  0.50 54.68  ? 300 CYS A HB3  1 
ATOM   4511 H HG   A CYS A 1 300 ? -12.892 7.177   -4.821  0.50 69.49  ? 300 CYS A HG   1 
ATOM   4512 H HG   B CYS A 1 300 ? -12.889 7.177   -4.824  0.50 69.25  ? 300 CYS A HG   1 
ATOM   4513 N N    . SER A 1 301 ? -15.750 10.427  -8.253  1.00 77.93  ? 301 SER A N    1 
ATOM   4514 C CA   . SER A 1 301 ? -16.942 11.130  -8.688  1.00 105.82 ? 301 SER A CA   1 
ATOM   4515 C C    . SER A 1 301 ? -17.994 10.121  -9.144  1.00 117.06 ? 301 SER A C    1 
ATOM   4516 O O    . SER A 1 301 ? -17.708 8.945   -9.375  1.00 99.45  ? 301 SER A O    1 
ATOM   4517 C CB   . SER A 1 301 ? -16.613 12.104  -9.817  1.00 107.49 ? 301 SER A CB   1 
ATOM   4518 H H    . SER A 1 301 ? -15.167 10.309  -8.874  1.00 93.57  ? 301 SER A H    1 
ATOM   4519 H HA   . SER A 1 301 ? -17.301 11.648  -7.950  1.00 127.04 ? 301 SER A HA   1 
ATOM   4520 N N    . GLY A 1 302 ? -19.227 10.596  -9.277  1.00 128.93 ? 302 GLY A N    1 
ATOM   4521 C CA   . GLY A 1 302 ? -20.337 9.752   -9.686  1.00 94.31  ? 302 GLY A CA   1 
ATOM   4522 C C    . GLY A 1 302 ? -20.081 8.970   -10.958 1.00 101.01 ? 302 GLY A C    1 
ATOM   4523 O O    . GLY A 1 302 ? -20.969 8.279   -11.467 1.00 95.75  ? 302 GLY A O    1 
ATOM   4524 H H    . GLY A 1 302 ? -19.447 11.415  -9.135  1.00 154.77 ? 302 GLY A H    1 
ATOM   4525 H HA2  . GLY A 1 302 ? -20.527 9.117   -8.977  1.00 113.23 ? 302 GLY A HA2  1 
ATOM   4526 H HA3  . GLY A 1 302 ? -21.119 10.308  -9.829  1.00 113.23 ? 302 GLY A HA3  1 
ATOM   4527 N N    . ASN B 2 1   ? 11.806  0.112   24.961  1.00 72.12  ? -6  ASN B N    1 
ATOM   4528 C CA   . ASN B 2 1   ? 12.431  1.456   25.165  1.00 75.45  ? -6  ASN B CA   1 
ATOM   4529 C C    . ASN B 2 1   ? 11.351  2.478   25.536  1.00 70.19  ? -6  ASN B C    1 
ATOM   4530 O O    . ASN B 2 1   ? 10.258  2.079   25.947  1.00 69.52  ? -6  ASN B O    1 
ATOM   4531 C CB   . ASN B 2 1   ? 13.212  1.878   23.916  1.00 80.00  ? -6  ASN B CB   1 
ATOM   4532 C CG   . ASN B 2 1   ? 12.331  2.045   22.695  1.00 91.05  ? -6  ASN B CG   1 
ATOM   4533 O OD1  . ASN B 2 1   ? 11.851  1.070   22.117  1.00 83.59  ? -6  ASN B OD1  1 
ATOM   4534 N ND2  . ASN B 2 1   ? 12.135  3.291   22.280  1.00 91.40  ? -6  ASN B ND2  1 
ATOM   4535 H H1   . ASN B 2 1   ? 12.195  -0.481  25.498  1.00 86.60  ? -6  ASN B H1   1 
ATOM   4536 H H2   . ASN B 2 1   ? 10.937  0.158   25.149  1.00 86.60  ? -6  ASN B H2   1 
ATOM   4537 H H3   . ASN B 2 1   ? 11.913  -0.139  24.114  1.00 86.60  ? -6  ASN B H3   1 
ATOM   4538 H HA   . ASN B 2 1   ? 13.072  1.426   25.893  1.00 90.60  ? -6  ASN B HA   1 
ATOM   4539 H HB2  . ASN B 2 1   ? 13.647  2.728   24.089  1.00 96.06  ? -6  ASN B HB2  1 
ATOM   4540 H HB3  . ASN B 2 1   ? 13.876  1.200   23.716  1.00 96.06  ? -6  ASN B HB3  1 
ATOM   4541 H HD21 . ASN B 2 1   ? 11.644  3.442   21.591  1.00 109.73 ? -6  ASN B HD21 1 
ATOM   4542 H HD22 . ASN B 2 1   ? 12.500  3.946   22.701  1.00 109.73 ? -6  ASN B HD22 1 
ATOM   4543 N N    A ARG B 2 2   ? 11.750  3.742   25.655  0.62 66.03  ? -5  ARG B N    1 
ATOM   4544 N N    B ARG B 2 2   ? 11.741  3.742   25.657  0.38 66.14  ? -5  ARG B N    1 
ATOM   4545 C CA   A ARG B 2 2   ? 10.871  4.809   26.110  0.62 60.55  ? -5  ARG B CA   1 
ATOM   4546 C CA   B ARG B 2 2   ? 10.847  4.793   26.115  0.38 60.78  ? -5  ARG B CA   1 
ATOM   4547 C C    A ARG B 2 2   ? 10.338  5.621   24.933  0.62 60.55  ? -5  ARG B C    1 
ATOM   4548 C C    B ARG B 2 2   ? 10.353  5.638   24.945  0.38 60.54  ? -5  ARG B C    1 
ATOM   4549 O O    A ARG B 2 2   ? 10.816  5.529   23.802  0.62 58.26  ? -5  ARG B O    1 
ATOM   4550 O O    B ARG B 2 2   ? 10.869  5.577   23.829  0.38 58.32  ? -5  ARG B O    1 
ATOM   4551 C CB   A ARG B 2 2   ? 11.613  5.736   27.087  0.62 62.56  ? -5  ARG B CB   1 
ATOM   4552 C CB   B ARG B 2 2   ? 11.555  5.680   27.146  0.38 62.72  ? -5  ARG B CB   1 
ATOM   4553 C CG   A ARG B 2 2   ? 12.068  5.065   28.373  0.62 68.55  ? -5  ARG B CG   1 
ATOM   4554 C CG   B ARG B 2 2   ? 11.842  4.988   28.469  0.38 68.34  ? -5  ARG B CG   1 
ATOM   4555 C CD   A ARG B 2 2   ? 13.128  5.891   29.126  0.62 75.48  ? -5  ARG B CD   1 
ATOM   4556 C CD   B ARG B 2 2   ? 13.026  5.623   29.187  0.38 75.37  ? -5  ARG B CD   1 
ATOM   4557 N NE   A ARG B 2 2   ? 14.119  6.500   28.244  0.62 85.24  ? -5  ARG B NE   1 
ATOM   4558 N NE   B ARG B 2 2   ? 13.048  5.298   30.609  0.38 86.25  ? -5  ARG B NE   1 
ATOM   4559 C CZ   A ARG B 2 2   ? 14.416  7.793   28.215  0.62 83.79  ? -5  ARG B CZ   1 
ATOM   4560 C CZ   B ARG B 2 2   ? 13.892  5.824   31.486  0.38 84.65  ? -5  ARG B CZ   1 
ATOM   4561 N NH1  A ARG B 2 2   ? 13.825  8.659   29.023  0.62 77.85  ? -5  ARG B NH1  1 
ATOM   4562 N NH1  B ARG B 2 2   ? 14.801  6.714   31.123  0.38 80.17  ? -5  ARG B NH1  1 
ATOM   4563 N NH2  A ARG B 2 2   ? 15.330  8.229   27.351  0.62 66.82  ? -5  ARG B NH2  1 
ATOM   4564 N NH2  B ARG B 2 2   ? 13.823  5.447   32.760  0.38 70.60  ? -5  ARG B NH2  1 
ATOM   4565 H H    A ARG B 2 2   ? 12.546  4.011   25.472  0.62 79.29  ? -5  ARG B H    1 
ATOM   4566 H H    B ARG B 2 2   ? 12.534  4.018   25.475  0.38 79.42  ? -5  ARG B H    1 
ATOM   4567 H HA   A ARG B 2 2   ? 10.116  4.409   26.569  0.62 72.72  ? -5  ARG B HA   1 
ATOM   4568 H HA   B ARG B 2 2   ? 10.074  4.385   26.535  0.38 73.00  ? -5  ARG B HA   1 
ATOM   4569 H HB2  A ARG B 2 2   ? 12.402  6.084   26.643  0.62 75.13  ? -5  ARG B HB2  1 
ATOM   4570 H HB2  B ARG B 2 2   ? 12.403  5.971   26.776  0.38 75.32  ? -5  ARG B HB2  1 
ATOM   4571 H HB3  A ARG B 2 2   ? 11.020  6.464   27.331  0.62 75.13  ? -5  ARG B HB3  1 
ATOM   4572 H HB3  B ARG B 2 2   ? 10.993  6.449   27.332  0.38 75.32  ? -5  ARG B HB3  1 
ATOM   4573 H HG2  A ARG B 2 2   ? 11.304  4.951   28.959  0.62 82.32  ? -5  ARG B HG2  1 
ATOM   4574 H HG2  B ARG B 2 2   ? 11.063  5.058   29.044  0.38 82.07  ? -5  ARG B HG2  1 
ATOM   4575 H HG3  A ARG B 2 2   ? 12.455  4.201   28.160  0.62 82.32  ? -5  ARG B HG3  1 
ATOM   4576 H HG3  B ARG B 2 2   ? 12.050  4.055   28.305  0.38 82.07  ? -5  ARG B HG3  1 
ATOM   4577 H HD2  A ARG B 2 2   ? 12.684  6.604   29.612  0.62 90.64  ? -5  ARG B HD2  1 
ATOM   4578 H HD2  B ARG B 2 2   ? 13.850  5.300   28.790  0.38 90.51  ? -5  ARG B HD2  1 
ATOM   4579 H HD3  A ARG B 2 2   ? 13.598  5.310   29.745  0.62 90.64  ? -5  ARG B HD3  1 
ATOM   4580 H HD3  B ARG B 2 2   ? 12.972  6.588   29.099  0.38 90.51  ? -5  ARG B HD3  1 
ATOM   4581 H HE   A ARG B 2 2   ? 14.542  5.983   27.703  0.62 102.35 ? -5  ARG B HE   1 
ATOM   4582 H HE   B ARG B 2 2   ? 12.475  4.726   30.898  0.38 103.56 ? -5  ARG B HE   1 
ATOM   4583 H HH11 A ARG B 2 2   ? 13.232  8.388   29.584  0.62 93.47  ? -5  ARG B HH11 1 
ATOM   4584 H HH11 B ARG B 2 2   ? 14.854  6.964   30.301  0.38 96.26  ? -5  ARG B HH11 1 
ATOM   4585 H HH12 A ARG B 2 2   ? 14.033  9.493   28.986  0.62 93.47  ? -5  ARG B HH12 1 
ATOM   4586 H HH12 B ARG B 2 2   ? 15.339  7.043   31.708  0.38 96.26  ? -5  ARG B HH12 1 
ATOM   4587 H HH21 A ARG B 2 2   ? 15.719  7.675   26.821  0.62 80.24  ? -5  ARG B HH21 1 
ATOM   4588 H HH21 B ARG B 2 2   ? 13.236  4.869   33.005  0.38 84.78  ? -5  ARG B HH21 1 
ATOM   4589 H HH22 A ARG B 2 2   ? 15.531  9.065   27.323  0.62 80.24  ? -5  ARG B HH22 1 
ATOM   4590 H HH22 B ARG B 2 2   ? 14.365  5.781   33.337  0.38 84.78  ? -5  ARG B HH22 1 
ATOM   4591 N N    . ALA B 2 3   ? 9.334   6.444   25.226  1.00 48.16  ? -4  ALA B N    1 
ATOM   4592 C CA   . ALA B 2 3   ? 8.829   7.386   24.241  1.00 43.58  ? -4  ALA B CA   1 
ATOM   4593 C C    . ALA B 2 3   ? 9.863   8.483   24.008  1.00 45.04  ? -4  ALA B C    1 
ATOM   4594 O O    . ALA B 2 3   ? 10.740  8.736   24.840  1.00 47.26  ? -4  ALA B O    1 
ATOM   4595 C CB   . ALA B 2 3   ? 7.512   8.011   24.702  1.00 42.85  ? -4  ALA B CB   1 
ATOM   4596 H H    . ALA B 2 3   ? 8.932   6.473   25.986  1.00 57.85  ? -4  ALA B H    1 
ATOM   4597 H HA   . ALA B 2 3   ? 8.657   6.923   23.406  1.00 52.36  ? -4  ALA B HA   1 
ATOM   4598 H HB1  . ALA B 2 3   ? 7.182   8.603   24.008  1.00 51.48  ? -4  ALA B HB1  1 
ATOM   4599 H HB2  . ALA B 2 3   ? 6.868   7.305   24.868  1.00 51.48  ? -4  ALA B HB2  1 
ATOM   4600 H HB3  . ALA B 2 3   ? 7.669   8.513   25.517  1.00 51.48  ? -4  ALA B HB3  1 
ATOM   4601 N N    . THR B 2 4   ? 9.743   9.147   22.866  1.00 43.74  ? -3  THR B N    1 
ATOM   4602 C CA   . THR B 2 4   ? 10.671  10.195  22.453  1.00 37.58  ? -3  THR B CA   1 
ATOM   4603 C C    . THR B 2 4   ? 9.865   11.459  22.184  1.00 43.81  ? -3  THR B C    1 
ATOM   4604 O O    . THR B 2 4   ? 9.106   11.520  21.211  1.00 40.63  ? -3  THR B O    1 
ATOM   4605 C CB   . THR B 2 4   ? 11.449  9.771   21.207  1.00 43.02  ? -3  THR B CB   1 
ATOM   4606 O OG1  . THR B 2 4   ? 12.204  8.587   21.489  1.00 46.53  ? -3  THR B OG1  1 
ATOM   4607 C CG2  . THR B 2 4   ? 12.390  10.877  20.741  1.00 45.29  ? -3  THR B CG2  1 
ATOM   4608 H H    . THR B 2 4   ? 9.114   9.006   22.297  1.00 52.55  ? -3  THR B H    1 
ATOM   4609 H HA   . THR B 2 4   ? 11.303  10.372  23.167  1.00 45.15  ? -3  THR B HA   1 
ATOM   4610 H HB   . THR B 2 4   ? 10.822  9.593   20.488  1.00 51.68  ? -3  THR B HB   1 
ATOM   4611 H HG1  . THR B 2 4   ? 11.700  7.994   21.805  1.00 55.90  ? -3  THR B HG1  1 
ATOM   4612 H HG21 . THR B 2 4   ? 12.986  10.538  20.055  1.00 54.41  ? -3  THR B HG21 1 
ATOM   4613 H HG22 . THR B 2 4   ? 11.878  11.616  20.376  1.00 54.41  ? -3  THR B HG22 1 
ATOM   4614 H HG23 . THR B 2 4   ? 12.919  11.198  21.488  1.00 54.41  ? -3  THR B HG23 1 
ATOM   4615 N N    . LEU B 2 5   ? 10.016  12.463  23.042  1.00 34.10  ? -2  LEU B N    1 
ATOM   4616 C CA   . LEU B 2 5   ? 9.442   13.773  22.751  1.00 35.54  ? -2  LEU B CA   1 
ATOM   4617 C C    . LEU B 2 5   ? 10.170  14.358  21.543  1.00 43.20  ? -2  LEU B C    1 
ATOM   4618 O O    . LEU B 2 5   ? 11.394  14.519  21.565  1.00 53.31  ? -2  LEU B O    1 
ATOM   4619 C CB   . LEU B 2 5   ? 9.554   14.691  23.960  1.00 37.33  ? -2  LEU B CB   1 
ATOM   4620 C CG   . LEU B 2 5   ? 8.752   14.266  25.195  1.00 51.13  ? -2  LEU B CG   1 
ATOM   4621 C CD1  . LEU B 2 5   ? 8.919   15.278  26.322  1.00 49.10  ? -2  LEU B CD1  1 
ATOM   4622 C CD2  . LEU B 2 5   ? 7.278   14.087  24.855  1.00 50.07  ? -2  LEU B CD2  1 
ATOM   4623 H H    . LEU B 2 5   ? 10.439  12.413  23.789  1.00 40.97  ? -2  LEU B H    1 
ATOM   4624 H HA   . LEU B 2 5   ? 8.498   13.689  22.546  1.00 42.71  ? -2  LEU B HA   1 
ATOM   4625 H HB2  . LEU B 2 5   ? 10.487  14.734  24.223  1.00 44.85  ? -2  LEU B HB2  1 
ATOM   4626 H HB3  . LEU B 2 5   ? 9.241   15.572  23.702  1.00 44.85  ? -2  LEU B HB3  1 
ATOM   4627 H HG   . LEU B 2 5   ? 9.094   13.412  25.502  1.00 61.41  ? -2  LEU B HG   1 
ATOM   4628 H HD11 . LEU B 2 5   ? 8.455   14.953  27.109  1.00 58.98  ? -2  LEU B HD11 1 
ATOM   4629 H HD12 . LEU B 2 5   ? 9.864   15.383  26.514  1.00 58.98  ? -2  LEU B HD12 1 
ATOM   4630 H HD13 . LEU B 2 5   ? 8.542   16.127  26.043  1.00 58.98  ? -2  LEU B HD13 1 
ATOM   4631 H HD21 . LEU B 2 5   ? 6.776   13.979  25.678  1.00 60.14  ? -2  LEU B HD21 1 
ATOM   4632 H HD22 . LEU B 2 5   ? 6.967   14.871  24.377  1.00 60.14  ? -2  LEU B HD22 1 
ATOM   4633 H HD23 . LEU B 2 5   ? 7.176   13.298  24.300  1.00 60.14  ? -2  LEU B HD23 1 
ATOM   4634 N N    . GLN B 2 6   ? 9.430   14.658  20.483  1.00 43.01  ? -1  GLN B N    1 
ATOM   4635 C CA   . GLN B 2 6   ? 10.060  15.040  19.221  1.00 50.20  ? -1  GLN B CA   1 
ATOM   4636 C C    . GLN B 2 6   ? 9.952   16.537  18.969  1.00 52.18  ? -1  GLN B C    1 
ATOM   4637 O O    . GLN B 2 6   ? 9.761   17.307  19.912  1.00 44.61  ? -1  GLN B O    1 
ATOM   4638 C CB   . GLN B 2 6   ? 9.437   14.240  18.072  1.00 39.12  ? -1  GLN B CB   1 
ATOM   4639 C CG   . GLN B 2 6   ? 10.133  12.901  17.830  1.00 45.73  ? -1  GLN B CG   1 
ATOM   4640 C CD   . GLN B 2 6   ? 9.411   12.031  16.822  1.00 42.43  ? -1  GLN B CD   1 
ATOM   4641 O OE1  . GLN B 2 6   ? 8.182   12.004  16.780  1.00 40.57  ? -1  GLN B OE1  1 
ATOM   4642 N NE2  . GLN B 2 6   ? 10.171  11.307  16.011  1.00 47.05  ? -1  GLN B NE2  1 
ATOM   4643 O OXT  . GLN B 2 6   ? 10.082  17.020  17.846  1.00 39.89  ? -1  GLN B OXT  1 
ATOM   4644 H H    . GLN B 2 6   ? 8.571   14.649  20.467  1.00 51.67  ? -1  GLN B H    1 
ATOM   4645 H HA   . GLN B 2 6   ? 11.007  14.833  19.256  1.00 60.30  ? -1  GLN B HA   1 
ATOM   4646 H HB2  . GLN B 2 6   ? 8.507   14.060  18.282  1.00 47.00  ? -1  GLN B HB2  1 
ATOM   4647 H HB3  . GLN B 2 6   ? 9.498   14.761  17.256  1.00 47.00  ? -1  GLN B HB3  1 
ATOM   4648 H HG2  . GLN B 2 6   ? 11.028  13.068  17.493  1.00 54.93  ? -1  GLN B HG2  1 
ATOM   4649 H HG3  . GLN B 2 6   ? 10.179  12.414  18.667  1.00 54.93  ? -1  GLN B HG3  1 
ATOM   4650 H HE21 . GLN B 2 6   ? 11.027  11.348  16.074  1.00 56.51  ? -1  GLN B HE21 1 
ATOM   4651 H HE22 . GLN B 2 6   ? 9.806   10.797  15.422  1.00 56.51  ? -1  GLN B HE22 1 
HETATM 4652 O O    . HOH C 3 .   ? -20.743 -9.548  -2.929  1.00 53.01  ? 401 HOH A O    1 
HETATM 4653 O O    . HOH C 3 .   ? -10.501 13.395  2.805   1.00 47.38  ? 402 HOH A O    1 
HETATM 4654 O O    . HOH C 3 .   ? -0.838  33.243  26.333  1.00 45.14  ? 403 HOH A O    1 
HETATM 4655 O O    . HOH C 3 .   ? 12.079  26.338  33.116  1.00 57.69  ? 404 HOH A O    1 
HETATM 4656 O O    . HOH C 3 .   ? 7.760   29.828  9.328   1.00 61.86  ? 405 HOH A O    1 
HETATM 4657 O O    . HOH C 3 .   ? 0.883   6.774   29.010  1.00 50.17  ? 406 HOH A O    1 
HETATM 4658 O O    . HOH C 3 .   ? -17.036 -13.970 16.641  1.00 54.93  ? 407 HOH A O    1 
HETATM 4659 O O    . HOH C 3 .   ? 9.968   11.051  8.719   1.00 44.35  ? 408 HOH A O    1 
HETATM 4660 O O    . HOH C 3 .   ? -26.934 -11.317 -3.253  1.00 67.76  ? 409 HOH A O    1 
HETATM 4661 O O    . HOH C 3 .   ? 6.285   32.032  33.887  1.00 41.75  ? 410 HOH A O    1 
HETATM 4662 O O    . HOH C 3 .   ? 10.785  35.780  19.780  1.00 65.96  ? 411 HOH A O    1 
HETATM 4663 O O    . HOH C 3 .   ? -21.186 5.746   13.576  1.00 55.01  ? 412 HOH A O    1 
HETATM 4664 O O    . HOH C 3 .   ? -2.449  30.816  5.665   1.00 50.98  ? 413 HOH A O    1 
HETATM 4665 O O    . HOH C 3 .   ? -7.483  -7.268  7.267   1.00 42.39  ? 414 HOH A O    1 
HETATM 4666 O O    . HOH C 3 .   ? -10.789 18.957  23.709  0.50 46.53  ? 415 HOH A O    1 
HETATM 4667 O O    . HOH C 3 .   ? 2.379   21.634  10.424  1.00 38.60  ? 416 HOH A O    1 
HETATM 4668 O O    . HOH C 3 .   ? -5.957  16.943  29.224  1.00 45.11  ? 417 HOH A O    1 
HETATM 4669 O O    . HOH C 3 .   ? -2.292  10.402  20.378  1.00 37.13  ? 418 HOH A O    1 
HETATM 4670 O O    . HOH C 3 .   ? -2.705  6.205   10.975  1.00 40.14  ? 419 HOH A O    1 
HETATM 4671 O O    . HOH C 3 .   ? -0.641  41.668  10.864  1.00 61.33  ? 420 HOH A O    1 
HETATM 4672 O O    . HOH C 3 .   ? 14.605  24.242  26.553  1.00 56.48  ? 421 HOH A O    1 
HETATM 4673 O O    . HOH C 3 .   ? -9.206  13.474  5.619   1.00 45.30  ? 422 HOH A O    1 
HETATM 4674 O O    . HOH C 3 .   ? 9.937   4.849   18.620  1.00 48.41  ? 423 HOH A O    1 
HETATM 4675 O O    . HOH C 3 .   ? 4.347   38.030  30.464  1.00 55.49  ? 424 HOH A O    1 
HETATM 4676 O O    . HOH C 3 .   ? -15.292 2.437   13.182  1.00 52.36  ? 425 HOH A O    1 
HETATM 4677 O O    . HOH C 3 .   ? -0.760  1.676   17.309  1.00 48.87  ? 426 HOH A O    1 
HETATM 4678 O O    . HOH C 3 .   ? -10.039 2.263   3.839   1.00 38.08  ? 427 HOH A O    1 
HETATM 4679 O O    . HOH C 3 .   ? 4.503   7.393   32.016  1.00 49.87  ? 428 HOH A O    1 
HETATM 4680 O O    . HOH C 3 .   ? -17.422 -1.576  -11.573 1.00 42.41  ? 429 HOH A O    1 
HETATM 4681 O O    . HOH C 3 .   ? -5.028  -3.649  -8.335  1.00 53.62  ? 430 HOH A O    1 
HETATM 4682 O O    . HOH C 3 .   ? -14.864 20.469  11.323  1.00 55.21  ? 431 HOH A O    1 
HETATM 4683 O O    . HOH C 3 .   ? -13.955 7.842   20.852  1.00 41.03  ? 432 HOH A O    1 
HETATM 4684 O O    . HOH C 3 .   ? 5.319   14.910  33.596  1.00 54.19  ? 433 HOH A O    1 
HETATM 4685 O O    . HOH C 3 .   ? -27.127 -1.611  1.826   1.00 48.43  ? 434 HOH A O    1 
HETATM 4686 O O    . HOH C 3 .   ? -8.601  20.633  18.037  1.00 44.97  ? 435 HOH A O    1 
HETATM 4687 O O    . HOH C 3 .   ? -28.895 -8.313  9.096   1.00 49.30  ? 436 HOH A O    1 
HETATM 4688 O O    . HOH C 3 .   ? 8.751   14.188  8.373   1.00 44.78  ? 437 HOH A O    1 
HETATM 4689 O O    . HOH C 3 .   ? 4.398   18.385  24.947  1.00 35.72  ? 438 HOH A O    1 
HETATM 4690 O O    . HOH C 3 .   ? -13.495 22.731  8.101   1.00 50.15  ? 439 HOH A O    1 
HETATM 4691 O O    . HOH C 3 .   ? -14.672 6.108   9.615   1.00 46.87  ? 440 HOH A O    1 
HETATM 4692 O O    . HOH C 3 .   ? -6.252  36.700  7.309   1.00 65.26  ? 441 HOH A O    1 
HETATM 4693 O O    . HOH C 3 .   ? -7.094  -9.637  10.708  1.00 54.62  ? 442 HOH A O    1 
HETATM 4694 O O    . HOH C 3 .   ? -6.289  26.142  22.352  1.00 44.56  ? 443 HOH A O    1 
HETATM 4695 O O    . HOH C 3 .   ? -1.224  21.625  31.990  1.00 49.64  ? 444 HOH A O    1 
HETATM 4696 O O    . HOH C 3 .   ? -10.162 18.015  11.253  1.00 39.12  ? 445 HOH A O    1 
HETATM 4697 O O    . HOH C 3 .   ? 12.273  21.732  14.414  1.00 45.46  ? 446 HOH A O    1 
HETATM 4698 O O    . HOH C 3 .   ? -2.421  -10.795 0.254   1.00 66.60  ? 447 HOH A O    1 
HETATM 4699 O O    . HOH C 3 .   ? -11.712 22.293  20.394  1.00 41.85  ? 448 HOH A O    1 
HETATM 4700 O O    . HOH C 3 .   ? -13.183 12.077  6.091   1.00 43.81  ? 449 HOH A O    1 
HETATM 4701 O O    . HOH C 3 .   ? 4.296   5.054   12.509  1.00 50.97  ? 450 HOH A O    1 
HETATM 4702 O O    . HOH C 3 .   ? -4.292  3.204   23.363  1.00 35.87  ? 451 HOH A O    1 
HETATM 4703 O O    . HOH C 3 .   ? -1.689  0.132   15.265  1.00 49.45  ? 452 HOH A O    1 
HETATM 4704 O O    . HOH C 3 .   ? -7.610  -12.559 7.271   1.00 57.54  ? 453 HOH A O    1 
HETATM 4705 O O    . HOH C 3 .   ? -4.583  -0.942  8.520   1.00 50.73  ? 454 HOH A O    1 
HETATM 4706 O O    . HOH C 3 .   ? -4.375  25.198  1.351   1.00 48.95  ? 455 HOH A O    1 
HETATM 4707 O O    . HOH C 3 .   ? -5.548  32.247  18.195  1.00 52.41  ? 456 HOH A O    1 
HETATM 4708 O O    . HOH C 3 .   ? -9.752  10.896  -0.762  1.00 33.50  ? 457 HOH A O    1 
HETATM 4709 O O    . HOH C 3 .   ? -15.104 7.389   13.088  1.00 46.68  ? 458 HOH A O    1 
HETATM 4710 O O    . HOH C 3 .   ? -7.283  10.455  0.766   1.00 42.10  ? 459 HOH A O    1 
HETATM 4711 O O    . HOH C 3 .   ? -24.881 7.974   -4.475  1.00 57.35  ? 460 HOH A O    1 
HETATM 4712 O O    . HOH C 3 .   ? -18.079 -7.431  15.836  1.00 59.34  ? 461 HOH A O    1 
HETATM 4713 O O    . HOH C 3 .   ? 0.624   14.615  29.537  1.00 49.05  ? 462 HOH A O    1 
HETATM 4714 O O    . HOH C 3 .   ? -27.412 -3.992  2.833   1.00 48.24  ? 463 HOH A O    1 
HETATM 4715 O O    . HOH C 3 .   ? -14.266 12.771  13.891  1.00 42.19  ? 464 HOH A O    1 
HETATM 4716 O O    . HOH C 3 .   ? -23.679 8.991   10.891  1.00 60.35  ? 465 HOH A O    1 
HETATM 4717 O O    . HOH C 3 .   ? -7.298  14.022  26.797  1.00 41.33  ? 466 HOH A O    1 
HETATM 4718 O O    . HOH C 3 .   ? -3.954  15.565  27.951  1.00 36.92  ? 467 HOH A O    1 
HETATM 4719 O O    . HOH C 3 .   ? -12.083 12.268  20.647  1.00 40.04  ? 468 HOH A O    1 
HETATM 4720 O O    . HOH C 3 .   ? -16.160 0.230   11.580  1.00 46.39  ? 469 HOH A O    1 
HETATM 4721 O O    . HOH C 3 .   ? -6.295  -5.577  8.723   1.00 54.44  ? 470 HOH A O    1 
HETATM 4722 O O    . HOH C 3 .   ? -23.931 -8.577  15.808  1.00 64.54  ? 471 HOH A O    1 
HETATM 4723 O O    . HOH C 3 .   ? -0.147  29.447  32.469  1.00 49.40  ? 472 HOH A O    1 
HETATM 4724 O O    . HOH C 3 .   ? -12.124 12.680  8.460   1.00 47.19  ? 473 HOH A O    1 
HETATM 4725 O O    . HOH C 3 .   ? -3.214  33.908  25.147  1.00 62.95  ? 474 HOH A O    1 
HETATM 4726 O O    . HOH C 3 .   ? 2.288   33.615  32.613  1.00 56.74  ? 475 HOH A O    1 
HETATM 4727 O O    . HOH C 3 .   ? -6.368  23.650  30.826  1.00 52.67  ? 476 HOH A O    1 
HETATM 4728 O O    . HOH C 3 .   ? 13.648  16.878  18.758  1.00 53.58  ? 477 HOH A O    1 
HETATM 4729 O O    . HOH C 3 .   ? -5.385  1.191   -2.207  1.00 41.92  ? 478 HOH A O    1 
HETATM 4730 O O    . HOH C 3 .   ? 7.076   35.088  33.578  1.00 48.24  ? 479 HOH A O    1 
HETATM 4731 O O    . HOH C 3 .   ? -17.915 3.243   -12.072 1.00 50.81  ? 480 HOH A O    1 
HETATM 4732 O O    . HOH C 3 .   ? -4.449  0.426   5.983   1.00 46.39  ? 481 HOH A O    1 
HETATM 4733 O O    . HOH C 3 .   ? -5.871  -8.297  -9.128  1.00 53.60  ? 482 HOH A O    1 
HETATM 4734 O O    . HOH C 3 .   ? -11.821 31.692  11.868  1.00 47.10  ? 483 HOH A O    1 
HETATM 4735 O O    . HOH C 3 .   ? 15.789  15.969  12.435  1.00 61.82  ? 484 HOH A O    1 
HETATM 4736 O O    . HOH C 3 .   ? -17.120 9.370   6.433   1.00 41.71  ? 485 HOH A O    1 
HETATM 4737 O O    . HOH C 3 .   ? 6.949   37.835  30.897  1.00 50.92  ? 486 HOH A O    1 
HETATM 4738 O O    . HOH C 3 .   ? 11.168  29.665  10.269  1.00 68.98  ? 487 HOH A O    1 
HETATM 4739 O O    . HOH C 3 .   ? 1.468   0.432   18.197  1.00 65.36  ? 488 HOH A O    1 
HETATM 4740 O O    . HOH C 3 .   ? 3.529   18.245  34.825  1.00 43.40  ? 489 HOH A O    1 
HETATM 4741 O O    . HOH C 3 .   ? -5.557  -7.624  4.951   1.00 46.96  ? 490 HOH A O    1 
HETATM 4742 O O    . HOH C 3 .   ? -7.228  25.211  0.357   1.00 57.33  ? 491 HOH A O    1 
HETATM 4743 O O    . HOH C 3 .   ? -23.369 1.910   -11.613 1.00 56.66  ? 492 HOH A O    1 
HETATM 4744 O O    . HOH C 3 .   ? -19.515 -14.937 2.099   1.00 64.88  ? 493 HOH A O    1 
HETATM 4745 O O    . HOH C 3 .   ? -0.730  10.669  1.570   1.00 52.17  ? 494 HOH A O    1 
HETATM 4746 O O    . HOH C 3 .   ? -2.006  13.719  29.022  1.00 52.72  ? 495 HOH A O    1 
HETATM 4747 O O    . HOH C 3 .   ? -11.629 -7.292  -11.473 1.00 40.81  ? 496 HOH A O    1 
HETATM 4748 O O    . HOH C 3 .   ? -15.645 13.936  18.484  1.00 38.28  ? 497 HOH A O    1 
HETATM 4749 O O    . HOH C 3 .   ? -12.706 -15.172 -7.718  1.00 67.70  ? 498 HOH A O    1 
HETATM 4750 O O    . HOH C 3 .   ? 6.237   31.904  8.629   1.00 58.78  ? 499 HOH A O    1 
HETATM 4751 O O    . HOH C 3 .   ? 13.854  24.332  36.028  1.00 55.90  ? 500 HOH A O    1 
HETATM 4752 O O    . HOH C 3 .   ? -10.355 20.288  20.199  1.00 55.54  ? 501 HOH A O    1 
HETATM 4753 O O    . HOH C 3 .   ? -0.000  -3.914  0.000   0.50 33.70  ? 502 HOH A O    1 
HETATM 4754 O O    . HOH C 3 .   ? 14.733  11.347  14.405  1.00 47.95  ? 503 HOH A O    1 
HETATM 4755 O O    . HOH C 3 .   ? -10.789 10.658  23.709  0.50 49.28  ? 504 HOH A O    1 
HETATM 4756 O O    . HOH C 3 .   ? 14.415  11.994  29.790  1.00 67.77  ? 505 HOH A O    1 
HETATM 4757 O O    . HOH C 3 .   ? -7.618  9.332   3.410   1.00 42.81  ? 506 HOH A O    1 
HETATM 4758 O O    . HOH C 3 .   ? 1.964   36.423  30.314  1.00 61.86  ? 507 HOH A O    1 
HETATM 4759 O O    . HOH C 3 .   ? 4.164   1.520   22.064  1.00 54.51  ? 508 HOH A O    1 
HETATM 4760 O O    . HOH C 3 .   ? -17.154 7.564   8.842   1.00 57.14  ? 509 HOH A O    1 
HETATM 4761 O O    . HOH C 3 .   ? -2.837  8.016   30.983  1.00 57.82  ? 510 HOH A O    1 
HETATM 4762 O O    . HOH C 3 .   ? -8.457  10.112  25.276  1.00 36.49  ? 511 HOH A O    1 
HETATM 4763 O O    . HOH C 3 .   ? -9.936  -11.760 18.386  1.00 67.04  ? 512 HOH A O    1 
HETATM 4764 O O    . HOH C 3 .   ? 1.553   14.806  32.193  1.00 55.62  ? 513 HOH A O    1 
HETATM 4765 O O    . HOH C 3 .   ? 2.414   31.186  32.394  1.00 54.78  ? 514 HOH A O    1 
HETATM 4766 O O    . HOH C 3 .   ? -13.508 9.086   -14.318 1.00 57.46  ? 515 HOH A O    1 
HETATM 4767 O O    . HOH C 3 .   ? -3.098  10.331  29.949  1.00 52.99  ? 516 HOH A O    1 
HETATM 4768 O O    . HOH C 3 .   ? -12.944 15.678  5.672   1.00 54.24  ? 517 HOH A O    1 
HETATM 4769 O O    . HOH C 3 .   ? -4.541  -2.524  12.312  1.00 70.24  ? 518 HOH A O    1 
HETATM 4770 O O    . HOH C 3 .   ? 12.027  22.189  3.196   1.00 58.78  ? 519 HOH A O    1 
HETATM 4771 O O    . HOH C 3 .   ? 4.137   30.405  34.863  1.00 59.44  ? 520 HOH A O    1 
HETATM 4772 O O    . HOH C 3 .   ? -0.808  6.660   -2.762  1.00 43.34  ? 521 HOH A O    1 
HETATM 4773 O O    . HOH C 3 .   ? -18.867 6.206   11.654  1.00 52.51  ? 522 HOH A O    1 
HETATM 4774 O O    . HOH C 3 .   ? -0.751  35.896  27.251  1.00 67.09  ? 523 HOH A O    1 
HETATM 4775 O O    . HOH C 3 .   ? 2.313   6.432   30.914  1.00 52.87  ? 524 HOH A O    1 
HETATM 4776 O O    . HOH C 3 .   ? -12.589 17.966  10.807  1.00 49.14  ? 525 HOH A O    1 
HETATM 4777 O O    . HOH C 3 .   ? -20.076 2.726   -10.369 1.00 55.95  ? 526 HOH A O    1 
HETATM 4778 O O    . HOH C 3 .   ? -5.458  -9.962  3.088   1.00 56.32  ? 527 HOH A O    1 
HETATM 4779 O O    . HOH C 3 .   ? -15.395 4.951   12.111  1.00 48.14  ? 528 HOH A O    1 
HETATM 4780 O O    . HOH C 3 .   ? 16.445  13.078  13.474  1.00 57.53  ? 529 HOH A O    1 
HETATM 4781 O O    . HOH C 3 .   ? -13.369 -3.869  18.206  1.00 60.08  ? 530 HOH A O    1 
HETATM 4782 O O    . HOH C 3 .   ? -2.333  17.922  31.226  1.00 55.56  ? 531 HOH A O    1 
HETATM 4783 O O    . HOH C 3 .   ? 10.614  21.171  0.498   1.00 66.62  ? 532 HOH A O    1 
HETATM 4784 O O    . HOH C 3 .   ? -29.588 -5.754  9.134   1.00 47.39  ? 533 HOH A O    1 
HETATM 4785 O O    . HOH C 3 .   ? -1.146  -2.550  16.129  1.00 56.79  ? 534 HOH A O    1 
HETATM 4786 O O    . HOH C 3 .   ? -8.109  5.208   26.587  1.00 40.51  ? 535 HOH A O    1 
HETATM 4787 O O    . HOH C 3 .   ? -20.999 10.177  1.614   1.00 57.33  ? 536 HOH A O    1 
HETATM 4788 O O    . HOH C 3 .   ? -10.609 29.092  19.334  1.00 59.39  ? 537 HOH A O    1 
HETATM 4789 O O    . HOH C 3 .   ? 0.000   6.258   0.000   0.50 43.81  ? 538 HOH A O    1 
HETATM 4790 O O    . HOH C 3 .   ? -6.853  -9.840  8.164   1.00 55.71  ? 539 HOH A O    1 
HETATM 4791 O O    . HOH D 3 .   ? 13.322  8.458   24.975  1.00 58.05  ? 101 HOH B O    1 
HETATM 4792 O O    . HOH D 3 .   ? 12.095  19.103  20.087  1.00 57.45  ? 102 HOH B O    1 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 ALA 145 145 145 ALA ALA A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 ?   ?   ?   A . n 
A 1 304 THR 304 304 ?   ?   ?   A . n 
A 1 305 PHE 305 305 ?   ?   ?   A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
B 2 1   ASN 1   -6  -6  ASN ASN B . n 
B 2 2   ARG 2   -5  -5  ARG ARG B . n 
B 2 3   ALA 3   -4  -4  ALA ALA B . n 
B 2 4   THR 4   -3  -3  THR THR B . n 
B 2 5   LEU 5   -2  -2  LEU LEU B . n 
B 2 6   GLN 6   -1  -1  GLN GLN B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 HOH 1   401 97  HOH HOH A . 
C 3 HOH 2   402 12  HOH HOH A . 
C 3 HOH 3   403 34  HOH HOH A . 
C 3 HOH 4   404 74  HOH HOH A . 
C 3 HOH 5   405 134 HOH HOH A . 
C 3 HOH 6   406 72  HOH HOH A . 
C 3 HOH 7   407 39  HOH HOH A . 
C 3 HOH 8   408 68  HOH HOH A . 
C 3 HOH 9   409 111 HOH HOH A . 
C 3 HOH 10  410 29  HOH HOH A . 
C 3 HOH 11  411 19  HOH HOH A . 
C 3 HOH 12  412 127 HOH HOH A . 
C 3 HOH 13  413 45  HOH HOH A . 
C 3 HOH 14  414 13  HOH HOH A . 
C 3 HOH 15  415 80  HOH HOH A . 
C 3 HOH 16  416 1   HOH HOH A . 
C 3 HOH 17  417 69  HOH HOH A . 
C 3 HOH 18  418 2   HOH HOH A . 
C 3 HOH 19  419 15  HOH HOH A . 
C 3 HOH 20  420 44  HOH HOH A . 
C 3 HOH 21  421 146 HOH HOH A . 
C 3 HOH 22  422 9   HOH HOH A . 
C 3 HOH 23  423 62  HOH HOH A . 
C 3 HOH 24  424 150 HOH HOH A . 
C 3 HOH 25  425 103 HOH HOH A . 
C 3 HOH 26  426 22  HOH HOH A . 
C 3 HOH 27  427 5   HOH HOH A . 
C 3 HOH 28  428 88  HOH HOH A . 
C 3 HOH 29  429 32  HOH HOH A . 
C 3 HOH 30  430 78  HOH HOH A . 
C 3 HOH 31  431 84  HOH HOH A . 
C 3 HOH 32  432 51  HOH HOH A . 
C 3 HOH 33  433 65  HOH HOH A . 
C 3 HOH 34  434 56  HOH HOH A . 
C 3 HOH 35  435 18  HOH HOH A . 
C 3 HOH 36  436 55  HOH HOH A . 
C 3 HOH 37  437 57  HOH HOH A . 
C 3 HOH 38  438 47  HOH HOH A . 
C 3 HOH 39  439 58  HOH HOH A . 
C 3 HOH 40  440 8   HOH HOH A . 
C 3 HOH 41  441 108 HOH HOH A . 
C 3 HOH 42  442 60  HOH HOH A . 
C 3 HOH 43  443 17  HOH HOH A . 
C 3 HOH 44  444 86  HOH HOH A . 
C 3 HOH 45  445 16  HOH HOH A . 
C 3 HOH 46  446 25  HOH HOH A . 
C 3 HOH 47  447 152 HOH HOH A . 
C 3 HOH 48  448 50  HOH HOH A . 
C 3 HOH 49  449 10  HOH HOH A . 
C 3 HOH 50  450 75  HOH HOH A . 
C 3 HOH 51  451 30  HOH HOH A . 
C 3 HOH 52  452 70  HOH HOH A . 
C 3 HOH 53  453 28  HOH HOH A . 
C 3 HOH 54  454 38  HOH HOH A . 
C 3 HOH 55  455 6   HOH HOH A . 
C 3 HOH 56  456 54  HOH HOH A . 
C 3 HOH 57  457 3   HOH HOH A . 
C 3 HOH 58  458 40  HOH HOH A . 
C 3 HOH 59  459 14  HOH HOH A . 
C 3 HOH 60  460 89  HOH HOH A . 
C 3 HOH 61  461 82  HOH HOH A . 
C 3 HOH 62  462 35  HOH HOH A . 
C 3 HOH 63  463 23  HOH HOH A . 
C 3 HOH 64  464 124 HOH HOH A . 
C 3 HOH 65  465 141 HOH HOH A . 
C 3 HOH 66  466 21  HOH HOH A . 
C 3 HOH 67  467 26  HOH HOH A . 
C 3 HOH 68  468 11  HOH HOH A . 
C 3 HOH 69  469 7   HOH HOH A . 
C 3 HOH 70  470 52  HOH HOH A . 
C 3 HOH 71  471 144 HOH HOH A . 
C 3 HOH 72  472 92  HOH HOH A . 
C 3 HOH 73  473 53  HOH HOH A . 
C 3 HOH 74  474 101 HOH HOH A . 
C 3 HOH 75  475 43  HOH HOH A . 
C 3 HOH 76  476 122 HOH HOH A . 
C 3 HOH 77  477 95  HOH HOH A . 
C 3 HOH 78  478 42  HOH HOH A . 
C 3 HOH 79  479 37  HOH HOH A . 
C 3 HOH 80  480 109 HOH HOH A . 
C 3 HOH 81  481 48  HOH HOH A . 
C 3 HOH 82  482 83  HOH HOH A . 
C 3 HOH 83  483 117 HOH HOH A . 
C 3 HOH 84  484 145 HOH HOH A . 
C 3 HOH 85  485 128 HOH HOH A . 
C 3 HOH 86  486 121 HOH HOH A . 
C 3 HOH 87  487 115 HOH HOH A . 
C 3 HOH 88  488 148 HOH HOH A . 
C 3 HOH 89  489 119 HOH HOH A . 
C 3 HOH 90  490 49  HOH HOH A . 
C 3 HOH 91  491 59  HOH HOH A . 
C 3 HOH 92  492 131 HOH HOH A . 
C 3 HOH 93  493 91  HOH HOH A . 
C 3 HOH 94  494 102 HOH HOH A . 
C 3 HOH 95  495 87  HOH HOH A . 
C 3 HOH 96  496 143 HOH HOH A . 
C 3 HOH 97  497 41  HOH HOH A . 
C 3 HOH 98  498 110 HOH HOH A . 
C 3 HOH 99  499 114 HOH HOH A . 
C 3 HOH 100 500 66  HOH HOH A . 
C 3 HOH 101 501 123 HOH HOH A . 
C 3 HOH 102 502 142 HOH HOH A . 
C 3 HOH 103 503 27  HOH HOH A . 
C 3 HOH 104 504 46  HOH HOH A . 
C 3 HOH 105 505 137 HOH HOH A . 
C 3 HOH 106 506 113 HOH HOH A . 
C 3 HOH 107 507 120 HOH HOH A . 
C 3 HOH 108 508 135 HOH HOH A . 
C 3 HOH 109 509 125 HOH HOH A . 
C 3 HOH 110 510 147 HOH HOH A . 
C 3 HOH 111 511 4   HOH HOH A . 
C 3 HOH 112 512 140 HOH HOH A . 
C 3 HOH 113 513 61  HOH HOH A . 
C 3 HOH 114 514 99  HOH HOH A . 
C 3 HOH 115 515 104 HOH HOH A . 
C 3 HOH 116 516 136 HOH HOH A . 
C 3 HOH 117 517 129 HOH HOH A . 
C 3 HOH 118 518 138 HOH HOH A . 
C 3 HOH 119 519 133 HOH HOH A . 
C 3 HOH 120 520 63  HOH HOH A . 
C 3 HOH 121 521 24  HOH HOH A . 
C 3 HOH 122 522 126 HOH HOH A . 
C 3 HOH 123 523 90  HOH HOH A . 
C 3 HOH 124 524 107 HOH HOH A . 
C 3 HOH 125 525 76  HOH HOH A . 
C 3 HOH 126 526 98  HOH HOH A . 
C 3 HOH 127 527 100 HOH HOH A . 
C 3 HOH 128 528 33  HOH HOH A . 
C 3 HOH 129 529 64  HOH HOH A . 
C 3 HOH 130 530 139 HOH HOH A . 
C 3 HOH 131 531 118 HOH HOH A . 
C 3 HOH 132 532 130 HOH HOH A . 
C 3 HOH 133 533 73  HOH HOH A . 
C 3 HOH 134 534 112 HOH HOH A . 
C 3 HOH 135 535 71  HOH HOH A . 
C 3 HOH 136 536 149 HOH HOH A . 
C 3 HOH 137 537 151 HOH HOH A . 
C 3 HOH 138 538 20  HOH HOH A . 
C 3 HOH 139 539 105 HOH HOH A . 
D 3 HOH 1   101 93  HOH HOH B . 
D 3 HOH 2   102 116 HOH HOH B . 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 4960  ? 
1 MORE         -20   ? 
1 'SSA (A^2)'  24490 ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z   1.0000000000  0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000 
2 'crystal symmetry operation' 2_555 -x,y,-z -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 415 ? C HOH . 
2 1 A HOH 502 ? C HOH . 
3 1 A HOH 504 ? C HOH . 
4 1 A HOH 538 ? C HOH . 
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2022-06-22 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? XSCALE      ? ? ? .           1 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER      ? ? ? .           2 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.19.1_4122 3 
? 'model building'  ? ? ? ? ? ? ? ? ? ? ? Coot        ? ? ? .           4 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? 3.27        5 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 50.19  -131.60 
2 1 ASP A 48  ? ? -91.35 57.70   
3 1 ASN A 84  ? ? 54.52  -117.92 
4 1 TYR A 154 ? ? 58.95  -122.05 
5 1 PRO A 184 ? ? -86.63 47.67   
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLU 47  ? CG  ? A GLU 47  CG  
2  1 Y 1 A GLU 47  ? CD  ? A GLU 47  CD  
3  1 Y 1 A GLU 47  ? OE1 ? A GLU 47  OE1 
4  1 Y 1 A GLU 47  ? OE2 ? A GLU 47  OE2 
5  1 Y 1 A ASP 48  ? CG  ? A ASP 48  CG  
6  1 Y 1 A ASP 48  ? OD1 ? A ASP 48  OD1 
7  1 Y 1 A ASP 48  ? OD2 ? A ASP 48  OD2 
8  1 Y 1 A ASN 72  ? CG  ? A ASN 72  CG  
9  1 Y 1 A ASN 72  ? OD1 ? A ASN 72  OD1 
10 1 Y 1 A ASN 72  ? ND2 ? A ASN 72  ND2 
11 1 Y 1 A GLN 74  ? CG  ? A GLN 74  CG  
12 1 Y 1 A GLN 74  ? CD  ? A GLN 74  CD  
13 1 Y 1 A GLN 74  ? OE1 ? A GLN 74  OE1 
14 1 Y 1 A GLN 74  ? NE2 ? A GLN 74  NE2 
15 1 Y 1 A LYS 100 ? CG  ? A LYS 100 CG  
16 1 Y 1 A LYS 100 ? CD  ? A LYS 100 CD  
17 1 Y 1 A LYS 100 ? CE  ? A LYS 100 CE  
18 1 Y 1 A LYS 100 ? NZ  ? A LYS 100 NZ  
19 1 Y 1 A ASP 153 ? CG  ? A ASP 153 CG  
20 1 Y 1 A ASP 153 ? OD1 ? A ASP 153 OD1 
21 1 Y 1 A ASP 153 ? OD2 ? A ASP 153 OD2 
22 1 Y 1 A TYR 154 ? CG  ? A TYR 154 CG  
23 1 Y 1 A TYR 154 ? CD1 ? A TYR 154 CD1 
24 1 Y 1 A TYR 154 ? CD2 ? A TYR 154 CD2 
25 1 Y 1 A TYR 154 ? CE1 ? A TYR 154 CE1 
26 1 Y 1 A TYR 154 ? CE2 ? A TYR 154 CE2 
27 1 Y 1 A TYR 154 ? CZ  ? A TYR 154 CZ  
28 1 Y 1 A TYR 154 ? OH  ? A TYR 154 OH  
29 1 Y 1 A ASP 155 ? CG  ? A ASP 155 CG  
30 1 Y 1 A ASP 155 ? OD1 ? A ASP 155 OD1 
31 1 Y 1 A ASP 155 ? OD2 ? A ASP 155 OD2 
32 1 Y 1 A LYS 236 ? CG  ? A LYS 236 CG  
33 1 Y 1 A LYS 236 ? CD  ? A LYS 236 CD  
34 1 Y 1 A LYS 236 ? CE  ? A LYS 236 CE  
35 1 Y 1 A LYS 236 ? NZ  ? A LYS 236 NZ  
36 1 Y 1 A ASN 277 ? CG  ? A ASN 277 CG  
37 1 Y 1 A ASN 277 ? OD1 ? A ASN 277 OD1 
38 1 Y 1 A ASN 277 ? ND2 ? A ASN 277 ND2 
39 1 Y 1 A SER 301 ? OG  ? A SER 301 OG  
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A VAL 303 ? A VAL 303 
2 1 Y 1 A THR 304 ? A THR 304 
3 1 Y 1 A PHE 305 ? A PHE 305 
4 1 Y 1 A GLN 306 ? A GLN 306 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           P01-GM109767 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_entity_nonpoly.entity_id   3 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
